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https://www.readbyqxmd.com/read/28528433/hydrolysis-of-phosphatidylcholine-isoprostanes-ptdcho-ip-by-peripheral-human-group-iia-v-and-x-secretory-phospholipases-a2-spla2
#1
Arnis Kuksis, Waldemar Pruzanski
Biologically active F- and E/D-type-prostane ring isomers (F2-IP and E2/D2-IP, respectively) are produced in situ by non-enzymatic peroxidation of arachidonic acid esterified to GroPCho (PtdCho-IP) and are universally distributed in tissue lipoproteins and cell membranes. Previous work has shown that platelet-activating factor acetylhydrolases (PAF-AH) are the main endogenous PLA2 involved in degradation of PtdCho-IP. The present study shows that the PtdCho-IP are also subject to hydrolysis by group IIA, V and X secretory PLA2, which also have a wide peripheral tissue distribution...
May 20, 2017: Lipids
https://www.readbyqxmd.com/read/28528430/risk-classification-of-highly-sensitive-troponin-i-predict-presence-of-vulnerable-plaque-assessed-by-dual-source-coronary-computed-tomography-angiography
#2
Ting Liu, Guan Wang, Peiling Li, Xu Dai
Patients presenting to the emergency department with acute chest pain, negative conventional troponin and electrocardiogram require serial testing to rule out acute coronary syndrome (ACS). We studied the association of highly sensitive troponin (hsTn) I with vulnerable plaque features as detected by coronary dual source computed tomography angiography (DSCTA) and determined whether hsTn I at the time of presentation combined with early DSCTA could improve classification of patients as high-risk or low risk for ACS...
May 20, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28528250/antifungal-toxicity-of-linear-geranylphenol-influence-of-oxigenate-substituents
#3
Lautaro Taborga, Maximiliano Sortino, Carrasco Héctor, Estefanía Butassi, Susana Zacchino, Luis Espinoza
Twenty four linear geranylphenols were evaluated for their antifungal properties against ATCC and clinical isolates of Candida albicans and Cryptococcus neoformans. For the analysis of their antifungal behavior the compounds were grouped into two series: (i) compounds with only one geranyl substituent on the benzene ring and (ii) compounds with two geranyl moieties on the benzene ring. Results showed that compounds of series (i) present better antifungal activities than those of series (ii). In addition, within group (i) all compounds showed better activities against C...
May 17, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28528109/the-hypoglycemic-effects-of-guava-leaf-psidium-guajava-l-extract-are-associated-with-improving-endothelial-dysfunction-in-mice-with-diet-induced-obesity
#4
Elixabet Díaz-de-Cerio, Alba Rodríguez-Nogales, Francesca Algieri, Miguel Romero, Vito Verardo, Antonio Segura-Carretero, Juan Duarte, Julio Galvez
Obesity is associated with a low-grade inflammatory status that affects vascular function. Previous studies have reported the beneficial effects of Psidium guajava L. (guava) on diabetes. Here we evaluate the how guava leaf extract at the dose of 5 mg/kg, affects vascular dysfunction in obese mice fed a high-fat diet for 7 weeks. Extract intake did not alter weight over time, although it reduced glycemia and insulin resistance, improving the serum lipid profile in obese mice. Additionally, guava leaf extract reversed the endothelial dysfunction found in obese mice in terms of endothelium- and NO (nitric oxide)-dependent vasodilatation induced by acetylcholine in aortic rings...
June 2017: Food Research International
https://www.readbyqxmd.com/read/28528010/long-term-safety-and-efficacy-of-a-sustained-release-bimatoprost-ocular-ring
#5
James D Brandt, Harvey B DuBiner, Robert Benza, Kenneth N Sall, Gary A Walker, Charles P Semba
No abstract text is available yet for this article.
May 17, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28527901/photonic-ring-resonance-is-a-versatile-platform-for-performing-multiplex-immunoassays-in-real-time
#6
Sasi Mudumba, Sophia de Alba, Randy Romero, Carli Cherwien, Alice Wu, Jue Wang, Martin A Gleeson, Muzammil Iqbal, Rufus W Burlingame
Photonic ring resonance is a property of light where in certain circumstances specific wavelengths are trapped in a ring resonator. Sensors based on silicon photonic ring resonators function by detecting the interaction between light circulating inside the sensor and matter deposited on the sensor surface. Binding of biological material results in a localized change in refractive index on the sensor surface, which affects the circulating optical field extending beyond the sensor boundary. That is, the resonant wavelength will change when the refractive index of the medium around the ring resonator changes...
May 17, 2017: Journal of Immunological Methods
https://www.readbyqxmd.com/read/28527876/short-term-exposure-of-erythropoietin-impairs-endothelial-function-through-inhibition-of-nitric-oxide-production-and-enos-mrna-expression-in-the-rat-pulmonary-artery
#7
Faheem Sultan, Thakur Uttam Singh, Tarun Kumar, Soya Rungsung, Dipankar Jyoti Rabha, Anamika Vishwakarma, Susanth V Sukumaran, Arunvikram Kandasamy, Subhashree Parida
BACKGROUND: Administration of recombinant erythropoietin (rEPO) is often associated with systemic and pulmonary arterial hypertension in animals and human. The present study was conducted to determine whether one-week rEPO-treatment can produce any effect on pulmonary vasomotor function. METHODS: Male Wistar rats were injected with rEPO (400IU/kg sc) or saline every other day for one week. Tension, biochemical and Real-Time PCR experiments were conducted on left and right branches of pulmonary artery and main pulmonary artery isolated from the rats...
February 4, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28527703/sperm-oocyte-contact-induces-outside-in-signaling-via-pyk2-activation
#8
Huizhen Wang, Jinping Luo, Carol Carlton, Lynda K McGinnis, William H Kinsey
Fertilization is a multi-step process that begins with plasma membrane interactions that enable sperm - oocyte binding followed by fusion of the sperm and oocyte plasma membranes. Once membrane fusion has occurred, sperm incorporation involves actin remodeling events within the oocyte cortex that allow the sperm head to penetrate the cortical actin layer and gain access to the ooplasm. Despite the significance for reproduction, the control mechanisms involved in gamete binding, fusion, and sperm incorporation are poorly understood...
May 17, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28527466/highly-excited-electronic-image-states-of-metallic-nanorings
#9
Christian Fey, Henrik Jabusch, Johannes Knörzer, Peter Schmelcher
We study electronic image states around a metallic nanoring and show that the interplay between the attractive polarization force and a repulsive centrifugal force gives rise to Rydberg-like image states trapped several nanometers away from the surface. The nanoring is modeled as a perfectly conducting isolated torus whose classical electrostatic image potential is derived analytically. The image states are computed via a two-dimensional finite-difference scheme as solutions of the effective Schrödinger equation describing the outer electron subject to this image potential...
May 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28527457/role-of-quantum-coherence-in-shaping-the-line-shape-of-an-exciton-interacting-with-a-spatially-and-temporally-correlated-bath
#10
Rajesh Dutta, Kaushik Bagchi, Biman Bagchi
Kubo's fluctuation theory of line shape forms the backbone of our understanding of optical and vibrational line shapes, through such concepts as static heterogeneity and motional narrowing. However, the theory does not properly address the effects of quantum coherences on optical line shape, especially in extended systems where a large number of eigenstates are present. In this work, we study the line shape of an exciton in a one-dimensional lattice consisting of regularly placed and equally separated optical two level systems...
May 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28527440/density-functional-study-of-structure-and-dynamics-in-liquid-antimony-and-sbn-clusters
#11
R O Jones, O Ahlstedt, J Akola, M Ropo
Density functional/molecular dynamics simulations have been performed on liquid antimony (588 atoms and six temperatures between 600 K and 1300 K) and on neutral Sb clusters with up to 14 atoms. We study structural patterns (coordination numbers, bond angles, and ring patterns, structure factors, pair distribution functions) and dynamical properties (vibration frequencies, diffusion constants, power spectra, dynamical structure factors, viscosity) and compare with available experimental results and with the results of our previous simulations on Bi...
May 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28527432/dealing-with-the-exponential-wall-in-electronic-structure-calculations
#12
Peter Fulde, Hermann Stoll
An alternative to the density functional theory is the use of wavefunction based electronic structure calculations for solids. In order to perform them, the Exponential Wall (EW) problem has to be resolved. It is caused by an exponential increase of the number of configurations with increasing electron number N. There are different routes one may follow. One is to characterize a many-electron wavefunction by a vector in Liouville space with a cumulant metric rather than in Hilbert space. This removes the EW problem...
May 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28527428/physicochemical-and-biological-interactions-between-cerium-oxide-nanoparticles-and-a-1-8-naphthalimide-derivative
#13
Gerardo Pulido-Reyes, Esperanza Martín, J L Gu Coronado, Francisco Leganes, Roberto Rosal, Francisca Fernández-Piñas
Cerium (Ce) oxide nanoparticles (CNPs) have attracted attention due to their high bioactivity and unique redox-chemistry. The oxygen vacancies at the surface of the nanoparticle explain the autocatalytic properties of CNPs in which the Ce(3+) atoms occupy the center of the oxygen vacancies surrounded by Ce(4+) atoms. Until now, CNPs have been associated with organic molecules at the synthesis stage to extend their applications or improve their stability. However, there is a lack of information regarding the post-synthesis interaction of CNPs and organic molecules that could enhance or induce new properties...
May 10, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28527419/ring-opening-polymerization-of-new-3-o-branched-1-6-anhydro-glucopyranose-di-and-trisaccharide-monomers
#14
Chaolumen Bai, Davaanyam Budragchaa, Takashi Yoshida
New 3-O-branched 1, 6-anhydro glucopyranose disaccharide monomers, 1, 6-anhydro-2, 4-di-O- benzyl-3-O-(2', 3', 4', 6'-tetra-O-benzyl-α-D-mannopyranosyl)- (LGM 6) and -glucopyranosyl)-β-D- glucopyranose (LGG 7), and a trisaccharide monomer, 1, 6-anhydro-2, 4-di-O-benzyl-3-O-α-(2', 3', 6', 2″, 3″, 4″, 6″-hepta-O-benzyl- α-D-maltopyranosyl)-β-D-glucopyranose (LGMAL 8), were synthesized and polymerized. It was found that the 3-O-branched1, 6-anhydro disaccharide monomers were polymerized. However, the polymerizability was lower than that of the 4-O-branched disaccharide monomers reported previously, and the trisaccharide monomer was not polymerizable, probably due to the steric hindrance of the branched bulky mono and disaccharide units at the 3-O position in 1, 6-anhydro glucopyranose...
April 22, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/28527405/synthesis-and-structure-activity-relationships-of-novel-fused-ring-analogues-of-q203-as-antitubercular-agents
#15
Sunhee Kang, Young Mi Kim, Heekyung Jeon, Sejin Park, Min Jung Seo, Saeyeon Lee, Dongsik Park, Jiyeon Nam, Seokwoo Lee, Kiyean Nam, Sanghee Kim, Jaeseung Kim
A set of fused ring analogues of a new antitubercular agent, Q203, was designed and synthesized. To reduce the lipophilicity of Q203 caused by linearly extended side chains, shorter and heteroatoms containing fused rings were introduced into the side chain region. Antitubercular activity was tested against H37Rv-GFP replicating in liquid broth culture medium (extracellular) and within macrophages (intracellular). Many analogues showed potent extracellular activities as well as intracellular activities without cytotoxicity...
May 10, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28527353/mechanical-behavior-of-the-abdominal-aortic-aneurysm-assessed-by-biaxial-tests-in-the-rat-xenograft-model
#16
Louise Marais, Mustapha Zidi
This paper addresses the mechanical biaxial behavior of degraded arteries obtained by the rat xenograft model. For that, a pressure myograph was used to perform extension-inflation tests on abdominal aortic aneurysms (AAAs). Furthermore, residual stresses in the aneurismal wall were assessed by opening angle tests. Thus, the changes in mechanical behavior between native murine aortas, decellularized guinea pig aortas (the grafts) and degraded aortas (AAAs) were investigated. It was shown that decellularized and degraded aortas exhibited a different mechanical behavior than native murine aortas...
May 12, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28526843/resonant-microwave-fields-and-negative-magnetic-response-induced-by-displacement-currents-in-dielectric-rings-theory-and-the-first-experiments
#17
A B Shvartsburg, V Ya Pecherkin, L M Vasilyak, S P Vetchinin, V E Fortov
The theoretical basis and experimental verification of resonant phenomena in the electromagnetic fields generated by displacement current in the near zone of dielectric ring is presented. According to the traditional viewpoint, the dielectric has an influence on the electric field inside resonator. To the contrary, we demonstrate that the dielectric ring exhibits magnetic properties at resonance. The sliding incidence of plane microwave on this weakly absorbing ring is shown to provide the sharp and deep resonance in the components of generated field; this low loss circuit is operating as a resonant dielectric magnetic dipole...
May 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28526743/systematic-identification-of-functional-residues-of-artemisia-annua-amorpha-4-11-diene-synthase
#18
Xin Fang, Jian-Xu Li, Jin-Quan Huang, You-Li Xiao, Peng Zhang, Xiao-Ya Chen
Terpene synthases (TPSs) are responsible for the extremely diversified and complex structure of terpenoids. Amorpha-4,11-diene synthase (ADS) has a high (90%) fidelity in generating the sesquiterpene precursor for biosynthesis of artemisinin, an antimalarial drug, however, little is known about how active site residues of ADS involved in the carbocation rearrangement and cyclization reactions. Here, we identify seven residues that are key to most of the catalytic steps in ADS. By structural modeling and amino acid sequence alignments of ADS with two functionally relevant sesquiterpene synthases from Artemisia annua, we performed site-directed mutagenesis and found that a single substitution, T296V, impaired the ring closure activity almost completely, and tetra-substitutions (L374Y/L404V/L405I/G439S) led to an enzyme generating 80% monocyclic bisabolyl-type sesquiterpenes, whereas a double mutant (T399L/T447G) showed compromised activity in regioselective deprotonation to yield 34...
May 19, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28526651/disruption-of-nnat-nap1l5-and-mkrn3-dna-methylation-and-transcription-in-rabbit-parthenogenetic-fetuses
#19
Dongxu Wang, Zhiquan Liu, Haobin Yao, Yang Hao, Lina Zhou, Jian Du, Yixin Zhu, Yuxin Xu, Guodong Wang, Yuning Song, Zhanjun Li
Parthenogenetically activated oocytes cannot develop to term in mammals due to lack of paternal gene expression. Disruption of imprinted gene expression and DNA methylation status in parthenogenetic fetuses has been reported in mice and pigs, but not in rabbits. In this study, the genomic imprinting status of the paternally expressed genes Neuronatin (NNAT), Nucleosome assembly protein 1-like 5 (NAP1L5), and Makorin ring finger protein 3 (MKRN3) was compared between rabbit parthenogenetic (PA) and normally fertilized fetuses (Con) using quantitative real-time PCR (qRT-PCR) and bisulfite sequencing PCR (BSP)...
May 16, 2017: Gene
https://www.readbyqxmd.com/read/28526600/preparation-and-nanoformulation-of-new-quinolone-scaffold-based-anticancer-agents-enhancing-solubility-for-better-cellular-delivery
#20
Nehal H Elghazawy, Amr Hefnawy, Nada K Sedky, Ibrahim M El-Sherbiny, Reem K Arafa
A new series of 5,7-dibromoquinoline scaffold-based derivatives with varied flexibility substituents at position 8 of the ring system has been synthesized as potential anticancer agents. The new compounds were evaluated for their in vitro antiproliferative activity versus the human breast cancer cell lines MCF-7 and MDA-MB231. Generally, both cell lines were responsive to the cytotoxic effect of the synthesized analogues. Compounds 4a, 5c and 7b were chosen for nanoformulation studies to assess the effect of enhancing their solubility profile on their cytotoxic ability...
May 16, 2017: European Journal of Pharmaceutical Sciences
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