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C Cursiefen, F Schaub, B Bachmann
BACKGROUND: The treatment of keratoconus has been significantly expanded in recent years. In addition to the previous options for correction by fitting hard contact lenses and penetrating keratoplasty (PK), corneal cross-linking and lamellar transplantation techniques have been added. OBJECTIVE: The aim of this review article is to highlight currently available options for minimization of complications and standardization of deep anterior lamellar keratoplasty (DALK) for keratoconus...
March 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
Sanja Sefic Kasumovic, Adisa Racic-Sakovic, Aida Kasumovic, Suzana Pavljasevic, Belkisa Duric-Colic, Emir Cabric, Milka Mavija, Orhan Lepara, Mirko Jankov
GOAL: This study aimed to investigate the differences in values of K1 and K2 readings, the central corneal thickness (PAH) before the collagen crosslinking procedure (CXL) and 3, 6, 12 months later. METHODS: 64 eyes were evaluated in retrospective cross sectional study. The corneal biomechanical parameters were taken with WaveLight Allegro Oculyzer produced by Alcon before the CXL, 3,6, 12 months after the procedure. The curvature of K1 reading and K2 reading were taken and the central corneal thickness were considered due to the time after CXL...
April 2015: Medical Archives
M Kohlhaas
Iatrogenic corneal ectasia is a rare complication but also one of the most feared situations that can occur after uneventful corneal laser surgery. Ectatic changes can occur as early as 1 week or can be delayed up to several years after LASIK. The actual incidence of ectasia is undetermined, an incidence rate of 0.04 to almost 2.8 % has been reported. Ectasia is most common following LASIK; however, cases have been reported following PRK and other corneal refractive procedures. Keratectasia shows progressive myopia, irregular astigmatism, ghosting, fluctuating vision and problems with scotopic vision...
June 2015: Klinische Monatsblätter Für Augenheilkunde
Jitka Čejková, Čestmír Čejka
In various corneal injuries (such as chemical burns or irradiation of corneas with UVB radiation) and ocular diseases (e.g. dry eye disease, keratokonus, bullous keratopathy, Fuchs' endothelial dystrophy), the expressions of malondialdehyde (a marker of lipid peroxidation) and nitrotyrosine (a marker of oxidative stress) appeared in cells of individual corneal layers and conjunctival cells (dry eye disease). This is in contrast to healthy corneas in which negligible levels of malondialdehyde and no expressions of nitrotyrosine are present...
August 2015: Histology and Histopathology
Paul-Rolf Preussner, Peter Hoffmann, Jochen Wahl
PURPOSE: To quantify the impact of posterior cornea on toric IOL calculation accuracy using Placido-topography of anterior corneal surface and Scheimpflug measurements of corneal thickness. MATERIALS AND METHODS: Three-hundred seventy-nine non-selected eyes undergoing cataract surgery with non-toric intraocular lens (IOL) implantation were measured with TMS-5 (Tomey, Japan), IOLMaster (Zeiss, Germany) and Lenstar (Haag-Streit, Switzerland). Anterior, posterior and total measured corneal astigmatisms were compared with astigmatisms from postoperative refraction by calculating vector differences...
2015: Current Eye Research
Sanja Sefic Kasumovic, Suzana Pavljasevic, Sabina Dacic-Lepara, Mirko Jankov
GOAL: To estimate corneal cross-linking (CXL) in keratoconus not only as a treatment to heal and increase the corneal stability then to consider it as a refractive procedure. METHODS: 28 eyes of 22 patients with progressive keratokonus were enrolled in prospective comparative study. Average follow up was 9 +/- 2 months (range 5 to 12 months). RESULTS: 6 months later uncorrected visual acuity (UCVA) was 0,2 (range 0,1 -0,5) and was significant higher to UCVA one month after the operation but not different to the results of UCVA before the CXL and three months later...
2013: Medical Archives
Philipp Steven, Carolin Le Blanc, Eva Lankenau, Marc Krug, Stefan Oelckers, Ludwig M Heindl, Uta Gehlsen, Gereon Huettmann, Claus Cursiefen
BACKGROUND/AIMS: To describe the use of intraoperative online optical coherence tomography (iOCT) for improving deep anterior lamellar keratoplasty (DALK) surgery. METHODS: Retrospective case series of 6 eyes of 6 male patients with keratokonus, corneal dystrophy or herpetic stromal scars undergoing DALK were investigated using intraoperative optical coherence tomography and postsurgical image/video analysis. Main outcome measures were: visibility of surgical steps, especially, assessment of placement depth of injection needle, preparation of bare Descemet's membrane and drainage of interface fluid...
July 2014: British Journal of Ophthalmology
Ara Ghazaryan, Halley F Tsai, Gor Hayrapetyan, Wei-Liang Chen, Yang-Fang Chen, Myung Yung Jeong, Chang-Seok Kim, Shean-Jen Chen, Chen-Yuan Dong
We present an automated and systematic two-dimensional discrete Fourier transform (2D-FFT) approach to analyze collagen fiber organization through the use of second harmonic generation (SHG) microscopy. Average orientations of individual domains and Ising-like order parameters introduced to characterize the correlation between orientations of adjacent domains may be used to quantitatively characterize fibrous tissues. Our approach was applied to analyze tissues including rat tail tendon, mouse skin, bovine corneas, and human corneas...
March 2013: Journal of Biomedical Optics
Jurica Predović, Tihomir Balog, Tanja Marotti, Nikica Gabrić, Maja Bohac, Ivana Romac, Iva Dekaris
We aim to find a link between keratokonus (KC) and bullous keratopathy (BK), and extra cellular matrix re-modellation molecules. The activities of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), pro-matrix metalloproteinase-13 (proMMP-13) and tissue inhibitor of matrix metalloproteinases-1 (TIMP-1) were measured using immunoassay in three human corneal tissue layers (epithelium, stroma and endothelium) supernatants of the patients with KC and BK which underwent the perforative keratoplasty...
October 2008: Collegium Antropologicum
E H Roth, H Ludwig, F Schmitz, W Werner
INTRODUCTION: Retinoscopy is a classical method to determine the refraction of the eye by observing the dynamics of reflexes and varying the experimental parameters until a specific reflex (neutralisation point) is observed. Until now photographs and geometrical drawings of the different ray tracings have been commonly used to visualise the pathways. We intend to use new media such as video and CD to offer the students a better understanding of retinoscopy. METHODS: With the aid of appropriate experimental devices, retinoscopal reflexes of artificial and human eyes are recorded on video...
October 2001: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
D Böhringer, T Reinhard, E Godehardt, R Sundmacher
BACKGROUND: For the characterisation of influencing factors on chronic endothelial cell loss after penetrating keratoplasty by means of multivariate statistics, a mathematical description of the course of the individual postoperative endothelial cell density is a prerequisite. This mathematical description should result in a standardized index value describing course and amount of the postoperative endothelial cell loss over time in a canonical way. The slopes of the linear regression lines for each individual scatter plot of a) the endothelial cell density values plotted against the respective postoperative time directly (linear regression), and b) after logarithmic transformation (exponential regression) are evaluated, respectively...
June 2001: Klinische Monatsblätter Für Augenheilkunde
N X Nguyen, A Langenbucher, B Seitz, M Graupner, C Cursiefen, M Küchle, G O Naumann
BACKGROUND: The purpose of this study was to quantify breakdown of the blood-aqueous barrier (BAB) following penetrating keratoplasty (PK) with simultaneous extracapsular cataract extraction and posterior chamber lens implantation (triple procedure) and compare it with the alterations following PK only. METHODS: This study included 72 eyes after triple procedure and 227 eyes after PK only. The diagnosis for PK was Fuchs dystrophy in 39%, keratokonus in 44%, stromal corneal dystrophy in 3% and avascular corneal scars in 6% of cases...
February 2001: Graefe's Archive for Clinical and Experimental Ophthalmology
S Goto, S Minoda, S Suzuki
We report a Down's syndrome patient who underwent penetrating keratoplasty (PKP) surgery. The patient was a 62-year-old female who had Down's syndrome with severe bilateral keratokonus and cataract. Her visual acuity was very poor as she did everything by touch before the surgery. We performed a triple procedure surgery, i.e., PKP, extracapsular cataract extraction, and posterior chamber intraocular lens implantation in her left eye. After the surgery her visual behavior improved markedly. This case shows that PKP surgery can be performed on such handicapped patients who are difficult handle in emergencies and need general anesthesia, because we have been able to keep the donor cornea longer than usual...
February 1995: Nippon Ganka Gakkai Zasshi
B Alberth
Description of a patient with keratoconus posticus acutus. The typical changes including thinning, were seen clinically on the posterior central surface of the left cornea with conical protrusion of the internal curvature. The right eye showed the classic signs of the acute phase.
December 1981: Klinische Monatsblätter Für Augenheilkunde
B Alberth, A Schnitzler
No abstract text is available yet for this article.
September 1971: Klinische Monatsblätter Für Augenheilkunde
T D Abugova, G A Babich, A A Kivaev
No abstract text is available yet for this article.
1985: Oftalmologicheskiĭ Zhurnal
H W Roth
Use of a computer connected with a slit-lamp-video-camera detected changes in the cornea topography after wearing contact lenses on a daily basis. Also subtle surface changes were observed within the upper portion of the areas measured. These appeared to be spiral-shaped or cloudlike patterns as a result of wearing hard or soft contact lenses respectively. The changes observed appeared to have resulted from movement of the contact lens. However, this device has also been used to determine changes that are similar in early keratokonus...
1989: Fortschritte der Ophthalmologie: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
J G Saal, P Fritz, B Zymela, M Zierhut, H Dürk, C A Müller, U Pleyer, H J Thiel
Corneal and conjunctival biopsies of 13 patients with rheumatoid arthritis and corneal ulceration (RA-keratomalacia) have been characterized by immunohistological and histochemical analysis. Biopsies from 13 patients with bacterial conjunctivitis, 7 patients with allergic conjunctivitis, 15 patients with senile cataract and 15 patients with keratokonus served as controls. The phenotypic composition of the conjunctival inflammatory infiltration of rheumatoid corneal ulceration was not significantly different from the other inflammatory eye diseases studied...
May 1991: Zeitschrift Für Rheumatologie
T Hoppeler, R Ganzfried, B Gloor
In a retrospective study, we investigated the survival of transplanted corneal material, which had been sent between 1988 and 1989 from the Zurich Eye Bank to both domestic and foreign physicians and clinics. A questionnaire was used to determine diagnosis, transplant survival, cause of any opacification, the occurrence of problems of epithelialisation, loosening of sutures, as well as vascularization of the host cornea. Of a total of 416 corneas, 327 or 79% could be evaluated. The mean follow-up periods of the various diagnostic groups ranged from 11 to 20 months, with a range of 1 to 35 months...
May 1992: Klinische Monatsblätter Für Augenheilkunde
T Reinhard, R Sundmacher
Endogenous eczema represents a considerable risk for perforating keratoplasty because of the associated chronic surface disorders and complex immunological disturbances. Between December 1986 through October 1991 we performed 24 perforating keratoplasties in 20 eyes of 18 patients with endogenous eczema suffering from keratokonus, atopic keratokonjunctivitis and bullous keratopathy after intracapsular cataract extraction. During the follow-up period of 16 (3-48) months 6 transplants failed mostly due to surface problems as well as immune reactions and bacterial transplant infections...
September 1992: Klinische Monatsblätter Für Augenheilkunde
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