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Cerebral Gliomas

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https://www.readbyqxmd.com/read/28320111/corrigendum-to-the-utility-of-diffusion-mri-with-quantitative-adc-measurements-for-differentiating-high-grade-from-low-grade-cerebral-gliomas-evidence-from-a-meta-analysis-j-neurol-sci-373-2017-9-15
#1
Li Zhang, Zhiqian Min, Min Tang, Sipan Chen, Xiaoyan Lei, Xiaoling Zhang
No abstract text is available yet for this article.
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28315948/-18f-fmiso-pet-study-of-hypoxia-in-gliomas-before-surgery-correlation-with-molecular-markers-of-hypoxia-and-angiogenesis
#2
Lien Bekaert, Samuel Valable, Emmanuèle Lechapt-Zalcman, Keven Ponte, Solène Collet, Jean-Marc Constans, Guénaëlle Levallet, Karim Bordji, Edwige Petit, Pierre Branger, Evelyne Emery, Alain Manrique, Louisa Barré, Myriam Bernaudin, Jean-Sébastien Guillamo
PURPOSE: Hypoxia in gliomas is associated with tumor resistance to radio- and chemotherapy. However, positron emission tomography (PET) imaging of hypoxia remains challenging, and the validation of biological markers is, therefore, of great importance. We investigated the relationship between uptake of the PET hypoxia tracer [18F]-FMISO and other markers of hypoxia and angiogenesis and with patient survival. PATIENTS AND METHODS: In this prospective single center clinical study, 33 glioma patients (grade IV: n = 24, III: n = 3, and II: n = 6) underwent [18F]-FMISO PET and MRI including relative cerebral blood volume (rCBV) maps before surgery...
March 18, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28315796/ultrasound-assisted-neuronavigation-guided-removal-of-a-live-worm-in-cerebral-sparganosis
#3
Sunday Nkwerem, Tetsuya Goto, Toshihiro Ogiwara, Yasunaga Yamamoto, Kazuhiro Hongo, Samuel Ohaegbulam
BACKGROUND: Cerebral sparganosis is a rare zoonotic infestation which often mimics glioma and metastatic tumors. CASE DESCRIPTION: A case of 71-year-old man who presented with disturbing dysarthria. Initial neuroimages were suggestive of glioma. The histology was, however, suggestive of inflammatory lesion. Follow-up neuroimages and serology were suggestive of sparganosis. He subsequently had craniotomy with ultrasound-guided aspiration of a live worm. Saline soaked surgicel was used to provide an acoustic window...
March 15, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28298040/noninvasive-assessment-of-isocitrate-dehydrogenase-mutation-status-in-cerebral-gliomas-by-magnetic-resonance-spectroscopy-in-a-clinical-setting
#4
Anna Tietze, Changho Choi, Bruce Mickey, Elizabeth A Maher, Benedicte Parm Ulhøi, Ryan Sangill, Yasmin Lassen-Ramshad, Slavka Lukacova, Leif Østergaard, Gorm von Oettingen
OBJECTIVE Mutations in the isocitrate dehydrogenase (IDH) genes are of proven diagnostic and prognostic significance for cerebral gliomas. The objective of this study was to evaluate the clinical feasibility of using a recently described method for determining IDH mutation status by using magnetic resonance spectroscopy (MRS) to detect the presence of 2-hydroxyglutarate (2HG), the metabolic product of the mutant IDH enzyme. METHODS By extending imaging time by 6 minutes, the authors were able to include a point-resolved spectroscopy (PRESS) MRS sequence in their routine glioma imaging protocol...
March 3, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28297689/-a-case-of-subcortical-intracerebral-hemorrhage-caused-by-underlying-oligodendroglioma-diagnosed-through-long-term-follow-up
#5
Masamune Kidoguchi, Makoto Isozaki, Satoshi Hirose, Ryuhei Kitai, Ken-Ichiro Kikuta
We report on a case of an oligodendroglioma that caused intracerebral hemorrhage, which was diagnosed by long-term follow-up. An 82-year-old man with underlying hypertrophic cardiomyopathy presented with weakness in the right upper extremity. Computed tomography and magnetic resonance imaging(MRI)showed intracerebral hemorrhage and focal brain edema. Since there was a discrepancy between hematoma and focal brain edema, we first diagnosed cardiogenic cerebral embolism. Six months later, MRI results showed an improvement of the brain edema; however, the lesion developed after a year...
March 2017: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/28290392/potential-for-differentiation-of-glioma-recurrence-from-radionecrosis-using-integrated-18-f-fluoroethyl-l-tyrosine-fet-positron-emission-tomography-magnetic-resonance-imaging-a-prospective-evaluation
#6
Shanti K Sogani, Amarnath Jena, Sangeeta Taneja, Aashish Gambhir, Anil K Mishra, Maria M D'Souza, Sapna M Verma, Puja P Hazari, Pradeep Negi, Ganesh K R Jadhav
PURPOSE: To assess the utility of 18F-fluoroethyl-L-tyrosine (FET) positron emission tomography/magnetic resonance imaging (PET/MRI) in distinguishing recurrence from radionecrosis. MATERIALS AND METHODS: Thirty-two patients (25 males, 7 females) of glioma who had already undergone surgery/chemoradiotherapy and had enhancing brain lesions suspicious of recurrence were evaluated using integrated 18F-FET PET/MRI, and followed up with histopathology or clinical follow-up and/or MRI/PET/MRI imaging...
March 2017: Neurology India
https://www.readbyqxmd.com/read/28269243/predictive-models-for-diffuse-low-grade-glioma-patients-under-chemotherapy
#7
Meriem Ben Abdallah, Marie Blonski, Sophie Wantz-Mezieres, Yann Gaudeau, Luc Taillandier, Jean-Marie Moureaux
Diffuse low-grade gliomas are rare primitive cerebral tumours of adults. These tumors progress continuously over time and then turn to a higher grade of malignancy associated with neurological disability, leading ultimately to death. Tumour size is one of the most important prognostic factors. Thus, it is of great importance to be able to assess the volume of the tumor during the patients' monitoring. MRI is nowadays the recommended modality to achieve this. Furthermore, if surgery remains the first option for diffuse low-grade gliomas, chemotherapy is increasingly used (before or after a possible surgery)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28266007/coincidental-feeding-artery-aneurysm-presenting-during-glioblastoma-surgery-a-case-report-and-literature-review
#8
Ümit Eroğlu, Eyyub S Al-Beyati, Elçin Özçelik Eroğlu, Gökmen Kahiloğullari
The medical literature reports an association between cerebral neoplasms and aneurysm formation. Some related aneurysms are detected during preoperative screening, whereas others are detected during or after surgery. We report a case of a patient with a de novo cerebral feeding artery aneurysm that we managed during glioblastoma surgery. We present a brief review of the literature on the co-existence of brain tumours, particularly that related to high-grade glioma and aneurysms. The literature discusses several mechanisms underlying tumour formation accompanied by aneurysm formation...
February 15, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28263047/mapping-the-connectome-in-awake-surgery-for-gliomas-an-update
#9
Hugues Duffau
The traditional principle underlying oncological neurosurgery is to remove a tumor mass displacing the brain in order to increase survival. Recently, advances in connectomics enabled an improved understanding of cerebral processing, and led to a paradigmatic shift in tumor surgery based upon interactions between neurooncology and cognitive neurosciences. First, glioma is not a focal tumor invaginated within the parenchyma but a diffuse neoplastic disease migrating in the brain. This concept resulted in a new surgical ideology, i...
March 6, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/28227477/predictive-models-for-diffuse-low-grade-glioma-patients-under-chemotherapy
#10
Meriem Ben Abdallah, Marie Blonski, Sophie Wantz-Mezieres, Yann Gaudeau, Luc Taillandier, Jean-Marie Moureaux, Meriem Ben Abdallah, Marie Blonski, Sophie Wantz-Mezieres, Yann Gaudeau, Luc Taillandier, Jean-Marie Moureaux, Luc Taillandier, Jean-Marie Moureaux, Marie Blonski, Yann Gaudeau, Sophie Wantz-Mezieres, Meriem Ben Abdallah
Diffuse low-grade gliomas are rare primitive cerebral tumours of adults. These tumors progress continuously over time and then turn to a higher grade of malignancy associated with neurological disability, leading ultimately to death. Tumour size is one of the most important prognostic factors. Thus, it is of great importance to be able to assess the volume of the tumor during the patients' monitoring. MRI is nowadays the recommended modality to achieve this. Furthermore, if surgery remains the first option for diffuse low-grade gliomas, chemotherapy is increasingly used (before or after a possible surgery)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28197403/network-plasticity-and-intraoperative-mapping-for-personalized-multimodal-management-of-diffuse-low-grade-gliomas
#11
REVIEW
Cristina Diana Ghinda, Hugues Duffau
Gliomas are the most frequent primary brain tumors and include a variety of different histological tumor types and malignancy grades. Recent achievements in terms of molecular and imaging fields have created an unprecedented opportunity to perform a comprehensive interdisciplinary assessment of the glioma pathophysiology, with direct implications in terms of the medical and surgical treatment strategies available for patients. The current paradigm shift considers glioma management in a comprehensive perspective that takes into account the intricate connectivity of the cerebral networks...
2017: Frontiers in Surgery
https://www.readbyqxmd.com/read/28179345/correlation-of-tumor-and-peritumoral-edema-volumes-with-survival-in-patients-with-cerebral-metastases
#12
Johannes Kerschbaumer, Marlies Bauer, Marina Popovscaia, Astrid E Grams, Claudius Thomé, Christian F Freyschlag
BACKGROUND: Surgical resection in combination with radiotherapy in selected cases remains the best option for patients with cerebral metastases. Postoperative relapse of brain metastases occurs frequently and can be reduced by postoperative whole-brain radiotherapy (WBRT). Continuous spread of tumor cells from the primary lesions is debated as a cause of recurrence. It is well known that in gliomas, infiltration takes place within the surrounding edema. Obviously, most brain metastases are usually associated with peritumoral edema, which may act as an indicator of infiltration and more aggressive tumor biology...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28162255/direct-electrical-bipolar-electrostimulation-for-functional-cortical-and-subcortical-cerebral-mapping-in-awake-craniotomy-practical-considerations
#13
J Pallud, O Rigaux-Viode, R Corns, J Muto, C Lopez Lopez, C Mellerio, X Sauvageon, E Dezamis
INTRODUCTION: The aim of brain glioma surgery is to maximize the quality of resection, while minimizing the risk of sequelae. Due to the frequent location of gliomas near or within eloquent areas, owing to their infiltrative feature, and because of major interindividual variability, the anatomofunctional organization and connectivity must be studied individually. Therefore, to optimize the benefit-to-risk ratio of surgery, intraoperative functional mapping is extensively used. MATERIAL AND METHODS: This article aims at describing the rationale, indications and practical aspects of intraoperative direct electrical bipolar electrostimulation for cortical and subcortical mapping under awake conditions using the asleep-awake asleep anaesthetic protocol in the setting of cerebral gliomas...
February 2, 2017: Neuro-Chirurgie
https://www.readbyqxmd.com/read/28152505/mean-cerebral-blood-volume-is-an-effective-diagnostic-index-of-recurrent-and-radiation-injury-in-glioma-patients-a-meta-analysis-of-diagnostic-test
#14
Zhanzhan Li, Qin Zhou, Yanyan Li, Shipeng Yan, Jun Fu, Xinqiong Huang, Liangfang Shen
We conducted a meta-analysis to evaluate the diagnostic values of mean cerebral blood volume for recurrent and radiation injury in glioma patients. We performed systematic electronic searches for eligible study up to August 8, 2016. Bivariate mixed effects models were used to estimate the combined sensitivity, specificity, positive likelihood ratios, negative likelihood ratios, diagnostic odds ratios and their 95% confidence intervals (CIs). Fifteen studies with a total number of 576 participants were enrolled...
January 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/28138871/clinical-relevance-of-steroid-use-in-neuro-oncology
#15
REVIEW
K Ina Ly, Patrick Y Wen
BACKGROUND: Corticosteroids are commonly used in the management of primary central nervous system (CNS) tumors and CNS metastases to treat cancer- and treatment-related cerebral edema and improve neurologic function. However, they are also associated with significant morbidity and mortality, given their wide range of adverse effects. PURPOSE OF REVIEW: To review the mechanism of action, pharmacology, and toxicity profile of corticosteroids and to critically appraise the evidence that supports their use in neuro-oncologic practice based on the latest scientific and clinical data...
January 2017: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/28133515/recognition-of-transmembrane-protein-39a-as-a-tumor-specific-marker-in-brain-tumor
#16
Jisoo Park, Hyunji Lee, Quangdon Tran, Kisun Mun, Dohoon Kim, Youngeun Hong, So Hee Kwon, Derek Brazil, Jongsun Park, Seon-Hwan Kim
Transmembrane protein 39A (TMEM39A) belongs to the TMEM39 family. TMEM39A gene is a susceptibility locus for multiple sclerosis. In addition, TMEM39A seems to be implicated in systemic lupus erythematosus. However, any possible involvement of TMEM39A in cancer remains largely unknown. In the present report, we provide evidence that TMEM39A may play a role in brain tumors. Western blotting using an anti-TMEM39A antibody indicated that TMEM39A was overexpressed in glioblastoma cell lines, including U87-MG and U251-MG...
January 2017: Toxicological Research
https://www.readbyqxmd.com/read/28131237/the-utility-of-diffusion-mri-with-quantitative-adc-measurements-for-differentiating-high-grade-from-low-grade-cerebral-gliomas-evidence-from-a-meta-analysis
#17
Li Zhang, Zhiqian Min, Min Tang, Sipan Chen, Xiaoyan Lei, Xiaoling Zhang
OBJECTIVE: The aim of this meta-analysis was to predict the grades of cerebral gliomas using quantitative apparent diffusion coefficient (ADC) values. MATERIALS AND METHODS: A comprehensive search of the PubMed, EMBASE, Web of Science, and Cochrane Library databases was performed up to 8, 2016. The quality assessment of diagnostic accuracy studies (QUADAS 2) was used to evaluate the quality of studies. Statistical analyses included pooling of sensitivity and specificity, positive likelihood ratio (PLR), negative likelihood ratio' (NLR), diagnostic odds ratio (DOR), and diagnostic accuracy values of the included studies using the summary receiver operating characteristic (SROC)...
February 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28130163/superselective-intra-arterial-cerebral-infusion-for-high-grade-gliomas-potential-imaging-biomarkers-of-response
#18
Matthew E Welz, Mithun G Sattur, Aman Gupta, Rami James N Aoun, Philias J Turcotte, Bernard R Bendok
No abstract text is available yet for this article.
March 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28128689/symmetry-of-the-arcuate-fasciculus-and-its-impact-on-language-performance-of-patients-with-brain-tumors-in-the-language-dominant-hemisphere
#19
Margit Jehna, Juliane Becker, Karla Zaar, Gord von Campe, Kariem Mahdy Ali, Gernot Reishofer, Franz Payer, Michael Synowitz, Franz Fazekas, Christian Enzinger, Hannes Deutschmann
OBJECTIVE Cerebral damage in frontal, parietal, and temporal brain areas and, probably more importantly, their interconnections can lead to deficits in language. However, neural plasticity and repair allow the brain to partly compensate for neural injury, mediated by both functional and structural changes. In this study, the authors sought to systematically investigate the relationship between language performance in brain tumor patients and structural perisylvian pathways (i.e., the arcuate fasciculus [AF]) using probabilistic fiber tracking on diffusion tensor imaging...
January 27, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28126976/-gliomatosis-cerebri-as-a-clinical-entity
#20
Kazuhiko Sugiyama
Gliomatosis cerebri is a rare subtype of glioma involving more than three lobes of the central nervous system. Currently, diagnosis of gliomatosis cerebri can be confirmed pathologically, surgically, or with magnetic resonance imaging that shows high-signal areas expanding to the cerebral hemisphere, brain stem, cerebellum, and spinal cord. Although this disease has great clinical importance, it has recently been removed from the revised WHO classification of Tumors of the Central Nervous System (2016) owing to divergence between its morphological features and molecular profiles...
January 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
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