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Cerebral Gliomas

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https://www.readbyqxmd.com/read/29324911/psychological-consideration-in-patients-with-cerebral-gliomas-candidates-for-intra-operative-radiation-therapy-based-on-tumor-location
#1
Tohid Emami Meybodi, Masoumeh Najafi, Ali Keipourfard, Amir Nikouei, Afsoun Seddighi
OBJECTIVE: Intra-operative Radiation Therapy (IORT) is gaining popularity as an adjuvant option to surgical resection, in treatment of glioblastoma multiforme (GBM) for increasing survival rate, which a highly aggressive cerebral tumor with poor prognosis. Τhe authors plan to investigate the effects of IORT combined with surgical resection on the psychological status of these patients based on tumor location. SUBJECT AND METHODS: From December 2013 to February 2017, we have enrolled 109 patients with high grade cerebral gliomas, documented by Magnetic Resonance Spectroscopy (MRS)...
September 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29248175/calvarium-mass-as-the-first-presentation-of-glioblastoma-multiforme-a-very-rare-manifestation-of-high-grade-glioma
#2
S Taghipour Zahir, M Mortaz, M Baghi Yazdi, N Sefidrokh Sharahjin, M Shabani
Glioblastoma multiforme (GBM) is a high grade glial tumor, primarily located in cerebral hemispheres. The most common clinical presentations are slowly progressive neurological deficit such as motor weakness, seizure, and headaches that last less than three months. Calvarium and extra-axial invasion are very rare and generally occur after a brain biopsy or surgery, or secondary to radiotherapy of primary intra-axial glial tumors. We report a case of GBM with calvarium involvement in a 60-year-old man who presented with a frontal bump and left-sided clumsiness...
December 13, 2017: Neuro-Chirurgie
https://www.readbyqxmd.com/read/29244086/cerebral-blood-flow-changes-after-radiation-therapy-identifies-pseudo-progression-in-diffuse-intrinsic-pontine-gliomas
#3
Raphael Calmon, Stephanie Puget, Pascale Varlet, Volodia Dangouloff-Ros, Thomas Blauwblomme, Kevin Beccaria, David Grevent, Christian Sainte-Rose, David Castel, Marie-Anne Debily, Christelle Dufour, Stéphanie Bolle, Frederic Dhermain, Ana Saitovitch, Monica Zilbovicius, Francis Brunelle, Jacques Grill, Nathalie Boddaert
Background: The interval between progression and death in diffuse intrinsic pontine glioma (DIPG) is usually < 6 months. However, reports of longer patient survival following radiotherapy, in the presence of radiological signs of progression, suggest that these cases may be comparable to pseudo-progression observed in adult glioblastoma. Our aim was to identify such cases and compare their multimodal MRI features with those of patients that did not present the same evolution. Methods: Multimodal MRI of 43 children treated for DIPG were retrospectively selected at four time points: baseline, after-radiotherapy, during true-progression, and at the last-visit...
December 13, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/29241176/surgery-of-intracranial-gliomas-in-children
#4
James A Balogun, James T Rutka
Gliomas are the most common type of brain cancer in the pediatric patients, constituting about 50% of all childhood intracranial tumors. This is a highly heterogeneous group, varying from the benign WHO histopathological grades I and II to malignant WHO grades III and IV. The histology and location are significant prognostic factors, which influence the decision for surgical intervention, as well as the extent of possible tumor removal. In low-grade gliomas, surgery remains the initial option and should be directed at gross total resection in favorable locations, such as the cerebral hemispheres and the cerebellum...
2018: Progress in Neurological Surgery
https://www.readbyqxmd.com/read/29241173/surgical-management-of-gliomas-in-eloquent-cortex
#5
Sherise D Ferguson, Ian E McCutcheon
Gliomas located in eloquent cortex impose a unique surgical obstacle. The oncological benefit of aggressive resection must be balanced with preservation of functional tissue and optimization of surgical outcome. Technical advances in preoperative functional imaging, refinement of intraoperative mapping, and conceptual understanding of cerebral plasticity have significantly improved the outcome of this patient population.
2018: Progress in Neurological Surgery
https://www.readbyqxmd.com/read/29241172/neurophysiological-monitoring-and-awake-craniotomy-for-resection-of-intracranial-gliomas
#6
Taiichi Saito, Manabu Tamura, Mikhail F Chernov, Soko Ikuta, Yoshihiro Muragaki, Takashi Maruyama
Aggressive resection of intracranial gliomas has a positive impact on patients' prognosis, but is associated with a risk of neurological complications. For preservation of brain functions and avoidance of major postoperative morbidity various methods of intraoperative neurophysiological monitoring have been introduced into clinical practice. At present, somatosensory evoked potentials (SSEP), motor evoked potentials (MEP), visual evoked potentials (VEP), brainstem auditory evoked potentials (BAEP), and electrocorticography (ECoG) are used routinely during neurosurgical procedures...
2018: Progress in Neurological Surgery
https://www.readbyqxmd.com/read/29223713/diagnostic-values-of-dce-mri-and-dsc-mri-for-differentiation-between-high-grade-and-low-grade-gliomas-a-comprehensive-meta-analysis
#7
Jianye Liang, Dexiang Liu, Peng Gao, Dong Zhang, Hanwei Chen, Changzheng Shi, Liangping Luo
RATIONALE AND OBJECTIVES: This study aimed to collect the studies on the role of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and dynamic susceptibility contrast MRI (DSC-MRI) in differentiating the grades of gliomas, and evaluate the diagnostic performances of relevant quantitative parameters in glioma grading. MATERIALS AND METHODS: We systematically searched studies on the diagnosis of gliomas with DCE-MRI or DSC-MRI in Medline, PubMed, China National Knowledge Infrastructure database, Cochrane Library, and Embase published between January 2005 and December 2016...
December 6, 2017: Academic Radiology
https://www.readbyqxmd.com/read/29215071/damage-of-the-right-dorsal-superior-longitudinal-fascicle-by-awake-surgery-for-glioma-causes-persistent-visuospatial-dysfunction
#8
Riho Nakajima, Masashi Kinoshita, Katsuyoshi Miyashita, Hirokazu Okita, Ryoji Genda, Tetsutaro Yahata, Yutaka Hayashi, Mitsutoshi Nakada
Patients with glioma frequently present with neuropsychological deficits preoperatively and/or postoperatively, and these deficits may remain after the chronic phase. However, little is known about postoperative recovery course of right hemispheric function. We therefore studied the characteristics and causes of persistent cognitive dysfunction in right cerebral hemispheric glioma. Eighteen patients who underwent awake surgery participated in this study. All patients who received preoperative neuropsychological examinations were assigned to two groups according to their test results: preoperative deficit and normal...
December 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29196975/paradoxical-activation-in-the-cerebellum-during-language-fmri-in-patients-with-brain-tumors-possible-explanations-based-on-neurovascular-uncoupling-and-functional-reorganization
#9
Nicholas S Cho, Kyung K Peck, Zhigang Zhang, Andrei I Holodny
The cerebellum is known for its crossed activation pattern with the contralateral cerebral hemisphere during language functional magnetic resonance imaging (fMRI) tasks in healthy patients. Crossed cerebro-cerebellar activation has been previously shown to occur in patients with brain tumors not affecting the activation areas. However, the presence of a tumor in left Broca's area in the inferior frontal gyrus is known to disrupt cerebral activation during language tasks. This study investigated if crossed cerebro-cerebellar activation patterns for language tasks would still occur in such patients...
December 1, 2017: Cerebellum
https://www.readbyqxmd.com/read/29184763/usefulness-of-enhancement-perfusion-mismatch-in-differentiation-of-cns-lymphomas-from-other-enhancing-malignant-tumors-of-the-brain
#10
Pradeep Goyal, Yogesh Kumar, Nishant Gupta, Ajay Malhotra, Saurabh Gupta, Sonali Gupta, Manisha Mangla, Rajiv Mangla
Background: Surgical planning and treatment options for primary or secondary central nervous system lymphomas (PCNSL or SCNSL) are different from other enhancing malignant lesions such as glioblastoma multiforme (GBM), anaplastic gliomas and metastases; so, it is critical to distinguish them preoperatively. We hypothesized that enhancement-perfusion (E-P) mismatch on dynamic susceptibility weighted magnetic resonance (DSC-MR) perfusion imaging which corresponds to low mean relative cerebral blood volume (mean rCBV) in an enhancing portion of the tumor should allow differentiation of CNS lymphomas from other enhancing malignant lesions...
October 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29135505/unusual-case-of-combined-gliomeningeal-heterotopia-on-the-nose-of-an-infant
#11
Anna Schauer, Nathan T Harvey, Shyan Vijayasekaran, Benjamin A Wood
Nasal glial heterotopia ("nasal glioma") and cutaneous heterotopic meningeal nodules ("primary cutaneous meningioma") are rare congenital lesions characterized by the presence of heterotopic mature cerebral tissues. Nasal glial heterotopia occurs predominantly in the nasal area and typically does not contain meningothelial elements, whereas heterotopic meningeal nodules occur predominantly on the scalp and do not contain glial elements. In this article, we report an unusual case of cutaneous heterotopia on the nose of an infant composed of both glial and meningothelial elements...
October 24, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29110365/magnetic-resonance-imaging-features-of-canine-gliomatosis-cerebri
#12
Daniela Schweizer-Gorgas, Diana Henke, Anna Oevermann, Johann Lang, Marc Vandevelde, Frank Steffen
A retrospective, case series study was undertaken to identify magnetic resonance imaging (MRI) characteristics of gliomatosis cerebri in dogs. Fourteen dogs were included by review of histopathological records and contemporaneous MRI. On MRI, all lesions presented as ill-defined, intraaxial lesions within the left and right forebrain hemispheres with involvement of white and gray matter. Lesions presented as hyperintense areas on T2-weighted and FLAIR sequences and as hypointense or isointense areas on T1-weighted images, with mild parenchymal contrast enhancement in three dogs...
November 6, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/29104150/differentiating-between-primary-central-nervous-system-lymphomas-and-glioblastomas-combined-use-of-perfusion-and-diffusion-weighted-magnetic-resonance-imaging
#13
Keishi Makino, Toshinori Hirai, Hideo Nakamura, Jun-Ichiro Kuroda, Naoki Shinojima, Hiroyuki Uetani, Mika Kitajima, Shigetoshi Yano
OBJECTIVE: The purpose of this study was to determine whether combined diffusion-weighted imaging (DWI) and dynamic susceptibility contrast-enhanced perfusion-weighted imaging (PWI) magnetic resonance imaging (MRI) can be used to differentiate between common malignant brain tumors, including lymphomas and high-grade gliomas. METHODS: We evaluated 87 patients with histologically confirmed brain tumors, including 33 primary central nervous system lymphomas (PCNSLs) and 54 glioblastomas (GBMs)...
November 2, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29098571/preoperative-relative-cerebral-blood-volume-analysis-in-gliomas-predicts-survival-and-mitigates-risk-of-biopsy-sampling-error
#14
Brendan J McCullough, Valerie Ader, Brian Aguedan, Xu Feng, Daniel Susanto, Tara L Benkers, John W Henson, Marc Mayberg, Charles S Cobbs, Ryder P Gwinn, Stephen J Monteith, David W Newell, Johnny Delashaw, Sarah J Fouke, Steven Rostad, Bart P Keogh
Appropriate management of adult gliomas requires an accurate histopathological diagnosis. However, the heterogeneity of gliomas can lead to misdiagnosis and undergrading, especially with biopsy. We evaluated the role of preoperative relative cerebral blood volume (rCBV) analysis in conjunction with histopathological analysis as a predictor of overall survival and risk of undergrading. We retrospectively identified 146 patients with newly diagnosed gliomas (WHO grade II-IV) that had undergone preoperative MRI with rCBV analysis...
November 2, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29090331/differentiation-of-grade-ii-iii-and-grade-iv-glioma-by-combining-t1-contrast-enhanced-brain-perfusion-imaging-and-susceptibility-weighted-quantitative-imaging
#15
Jitender Saini, Pradeep Kumar Gupta, Prativa Sahoo, Anup Singh, Rana Patir, Suneeta Ahlawat, Manish Beniwal, K Thennarasu, Vani Santosh, Rakesh Kumar Gupta
PURPOSE: MRI is a useful method for discriminating low- and high-grade glioma using perfusion MRI and susceptibility-weighted imaging (SWI). The purpose of this study is to evaluate the usefulness of T1-perfusion MRI and SWI in discriminating among grade II, III, and IV gliomas. METHODS: T1-perfusion MRI was used to measure relative cerebral blood volume (rCBV) in 129 patients with glioma (70 grade IV, 33 grade III, and 26 grade II tumors). SWI was also used to measure the intratumoral susceptibility signal intensity (ITSS) scores for each tumor in these patients...
October 31, 2017: Neuroradiology
https://www.readbyqxmd.com/read/29076908/aids-related-central-nervous-system-toxoplasmosis-with-increased-18f-fluoroethyl-l-tyrosine-amino-acid-pet-uptake-due-to-lat1-2-expression-of-inflammatory-cells
#16
Markus Hutterer, Elisabeth Bumes, Markus J Riemenschneider, Jirka Grosse, Dirk Hellwig, Norbert Galldiks, Karl-Josef Langen, Peter Hau
We report the case of a 40-year-old woman with a progressive right-sided hemiparesis. Standard MRI revealed a contrast-enhancing brain lesion within the left basal ganglia. Ffluoroethyl-L-tyrosine (F-FET) PET showed a distinct tracer uptake (lesion-to-brain ratio [LBR]: LBRmax = 2.03, LBRmean = 1.68) with a significant larger metabolic lesion volume than contrast-enhancement in MRI, indicating cerebral glioma. Surprisingly, histopathologic analysis demonstrated central nervous system toxoplasmosis with pronounced inflammatory reaction (reactive astrogliosis, microglia activation, macrophage, and T-lymphocyte infiltration), which was associated with strong LAT1/LAT2/CD98 expression...
October 26, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29061383/release-of-soluble-and-vesicular-purine-nucleoside-phosphorylase-from-rat-astrocytes-and-microglia-induced-by-pro-inflammatory-stimulation-with-extracellular-atp-via-p2x7-receptors
#17
Luis Emiliano Peña-Altamira, Elisabetta Polazzi, Patricia Giuliani, Alina Beraudi, Francesca Massenzio, Ilaria Mengoni, Alessandro Poli, Mariachiara Zuccarini, Renata Ciccarelli, Patrizia Di Iorio, Marco Virgili, Barbara Monti, Francesco Caciagli
Purine nucleoside phosphorylase (PNP), a crucial enzyme in purine metabolism which converts ribonucleosides into purine bases, has mainly been found inside glial cells. Since we recently demonstrated that PNP is released from rat C6 glioma cells, we then wondered whether this occurs in normal brain cells. Using rat primary cultures of microglia, astrocytes and cerebellar granule neurons, we found that in basal condition all these cells constitutively released a metabolically active PNP with Km values very similar to those measured in C6 glioma cells...
October 20, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/29048682/snhg15-affects-the-growth-of-glioma-microvascular-endothelial-cells-by-negatively-regulating-mir-153
#18
Yawen Ma, Yixue Xue, Xiaobai Liu, Chengbin Qu, Heng Cai, Ping Wang, Zhiqing Li, Zhen Li, Yunhui Liu
Malignant glioma, the most common intracranial primary tumor, is characterized by increased angiogenesis. Accumulating evidence has shown that long non-coding RNAs (lncRNAs) play an important role in a variety of biological behaviors of tumors. However, the role of lncRNAs in the regulation of glioma vascular endothelial cell function remains to be investigated. To simulate the glioma microenvironment, we applied glioma conditioned medium (GCM) to human cerebral microvascular endothelial cells (hCMECs). In the present study, the lncRNA SNHG15 was found to be highly expressed in glioma vascular endothelial cells...
September 21, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29044454/the-role-of-telovelar-approach-in-fourth-ventricular-surgery-a-new-perspective
#19
Ehab Eissa
OBJECTIVE: Evaluation the efficiency of the telovelar approach for 4th ventricular lesions through identifying and preserving neurovascular structures. METHODS: Forty cases of fourth ventricular tumours using the telovelar approach Results: It provides adequate exposure in all cases. The brainstem and posterior inferior cerebellar artery (PICA) were early identified and preserved in all cases. Potential tumour attachment was observed at the floor of the fourth ventricle in twenty two (55%) cases, 5 of them were brain stem glioma...
August 31, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/29042922/endoscopy-in-the-treatment-of-slit-ventricle-syndrome
#20
Jiaping Zheng, Guoqiang Chen, Qing Xiao, Yiyang Huang, Yupeng Guo
The present study aimed to investigate the efficacy of endoscopy in the treatment of post-shunt placement for slit ventricle syndrome (SVS). Endoscopic surgery was performed on 18 patients with SVS between October 2004 and December 2012. Sex, age, causes of the hydrocephalus, ventricular size and imaging data were collected and analyzed. All patients were divided into two groups according to ventricular size and underwent endoscopic surgeries, including endoscopic third ventriculostomy (ETV), endoscopic aqueductoplasty and cystocisternostomy...
October 2017: Experimental and Therapeutic Medicine
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