Kalliopi Domvri, Dimitrios Bougiouklis, Paul Zarogoulidis, Konstantinos Porpodis, Manolis Xristoforidis, Alexandra Liaka, Ellada Eleutheriadou, Sofia Lampaki, George Lazaridis, John Organtzis, George Kyriazis, Wolfgang Hohenforst-Schmidt, Katerina Tsirgogianni, Vasilis Karavasilis, Sofia Baka, Kaid Darwiche, Lutz Freitag, Georgia Trakada, Konstantinos Zarogoulidis
PURPOSE: Somatostatin is a peptide with a potent and broad antisecretory action, which makes it an invaluable drug target for the pharmacological management of pituitary adenomas and neuroendocrine tumors. Furthermore, somatostatin (SST) receptors (SSTR1, 2A and B, 3, 4 and 5) belong to the G protein coupled receptor family and are overexpressed in tumors. Since, human small-cell lung cancer overexpresses somatostatin receptors (STTR), they could be legitimate targets for treating SCLC...
2015: Journal of Cancer