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Hui Wang, Weiying Li, Baitang Lai, Xuehui Yang, Chunyan Zhang, Hong Tao, Yunzhong Zhu, Jinzhao Li
INTRODUCTION: The C-terminus of p53 and non-coding mRNAs play critical roles in negative regulation. However, their impact on anti-cancer drug sensitivity remains unclear. METHODS: In this study, we investigated the effects of p53 deleting these sequences on anti-cancer drug sensitivity by drug sensitivity test, flow cytometry, Agilent mRNA expression microarray detection, transplantation tumor in nude mice. RESULTS: The results showed that the cell line with p53 deleted the C-terminal sequences (p53(del)) was more sensitive to navelbine (NVB) compared to the cell line that carried the full length p53 (p53(wt))...
December 15, 2016: Gene
Hui Pang, Ting Feng, Hailing Lu, Qingwei Meng, Xuesong Chen, Qiang Shen, Xiaoqun Dong, Li Cai
PURPOSE: To compare the time-to-treatment failure (TTF), overall survival (OS), overall response rate (ORR), and adverse effects of regimens including nedaplatin- or cisplatin-based chemotherapy for advanced breast cancer (ABC). METHODS: A total of 171 patients with ABC (admission between July 2008 and July 2013) were retrospectively analyzed. Patients received either nedaplatin 75 mg/m(2) (arm N; n = 85) or cisplatin 75 mg/m(2) (arm C; n = 86) in combination with other second-generation chemotherapeutic drugs, such as paclitaxel 175 mg/m(2), docetaxel 75 mg/m(2), gemcitabine 1...
2016: Cancer Investigation
Prudence Anne Russell, Gavin Michael Wright
The recently published 2015 World Health Organisation (WHO) classification of lung tumors, which is based on the 2011 International Association for the Study of Lung Cancer (IASLC)/American Thoracic Society (ATS)/European Respiratory Society (ATS) multidisciplinary classification, recommends diagnosis of resected lung adenocarcinoma according to the predominant histologic subtype. This has been shown to correlate with overall and disease-free survival (DFS) in many studies from four continents. Now classification according to predominant histologic subtype has been demonstrated to predict benefit from adjuvant chemotherapy in a subset of patients with completely resected lung adenocarcinoma previously included in the International Adjuvant Lung Cancer Trial (IALT), JBR...
January 2016: Annals of Translational Medicine
Eirini Biziota, Evangelos Briasoulis, Leonidas Mavroeidis, Marios Marselos, Adrian L Harris, Periklis Pappas
Metronomic oral vinorelbine (VRL; Navelbine) was shown in clinical trials to yield sustainable antitumor activity possibly through antiangiogenic mechanisms. We investigated the effects of protracted low-dose VRL on human umbilical vein endothelial cells, compared with a conventional chemotherapy model. Human umbilical vein endothelial cell cultures were treated with different concentrations of VRL (0.001 nmol/l to 1 mmol/l) for 4, 24 and 96 h. The effects of different drug concentrations on cell growth, cell cycle, apoptosis and expression of the angiogenesis-modulating genes interleukin-8, cyclooxygenase-2, CD36 and peroxisome proliferator-activated receptor γ were assessed using the metronomic or conventional chemotherapy model...
March 2016: Anti-cancer Drugs
Hong Shi, Xiaoyan Zhang, Fei Wang, Daoming Liu
OBJECTIVE: Gefitinib is effective epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) for advanced non-small cell lung cancer (NSCLC) patients, but with the drug use, inevitable gefitinib-resistance and severe complications were observed and resulted in failure treatments. The purpose of the present study was to investigate the curative effect of different treatment of navelbine plus cisplatin in combination with gefitinib and gefitinib single on gefitinib-resistance advanced NSCLC patients...
2015: International Journal of Clinical and Experimental Medicine
Dogan Uncu, Ibrahim Vedat Bayoglu, Ulku Yalcintas Arslan, Mehmet Kucukoner, Mehmet Artac, Dogan Koca, Arzu Oguz, Umut Demirci, Erkan Arpaci, Mutlu Dogan, Yuksel Kucukzeybek, Ibrahim Turker, Abdurrahman Isikdogan, Tunc Guler, Nurullah Zengin
BACKGROUND: For HER2 positive metastatic breast cancer (MBC), continuing anti-HER2 therapy beyond progression is associated with improved outcome. However retreatment with trastuzumab after lapatinib progression is controversial. We retrospectively analyzed the efficacy of trastuzumab-based chemotherapy in HER2+ metastatic breast cancer patients whose disease progressed after lapatinib. MATERIALS AND METHODS: Between October 2010 and May 2013, 54 patients whose disease progressed after lapatinib were retreated with trastuzumab-based chemotherapy...
2015: Asian Pacific Journal of Cancer Prevention: APJCP
Zhengzi Qian, Zheng Song, Huilai Zhang, Xianhuo Wang, Jing Zhao, Huaqing Wang
T-cell lymphoma (TCL) is resistant to conventional chemotherapy. We retrospectively evaluated the therapeutic efficiency and toxicity of gemcitabine, navelbine, and doxorubicin (GND) in patients with refractory or relapsed TCL. From 2002 to 2012, 69 patients with refractory or relapsed TCL received GND treatment in our hospital. The treatment protocol comprised gemcitabine (800 mg/m(2), group 1; 1000 mg/m(2), group 2) on days 1 and 8, navelbine (25 mg/m(2)) on day 1, and doxorubicin (20 mg/m(2)) on day 1, repeated every 3 weeks...
2015: BioMed Research International
Kalliopi Domvri, Dimitrios Bougiouklis, Paul Zarogoulidis, Konstantinos Porpodis, Manolis Xristoforidis, Alexandra Liaka, Ellada Eleutheriadou, Sofia Lampaki, George Lazaridis, John Organtzis, George Kyriazis, Wolfgang Hohenforst-Schmidt, Katerina Tsirgogianni, Vasilis Karavasilis, Sofia Baka, Kaid Darwiche, Lutz Freitag, Georgia Trakada, Konstantinos Zarogoulidis
PURPOSE: Somatostatin is a peptide with a potent and broad antisecretory action, which makes it an invaluable drug target for the pharmacological management of pituitary adenomas and neuroendocrine tumors. Furthermore, somatostatin (SST) receptors (SSTR1, 2A and B, 3, 4 and 5) belong to the G protein coupled receptor family and are overexpressed in tumors. Since, human small-cell lung cancer overexpresses somatostatin receptors (STTR), they could be legitimate targets for treating SCLC...
2015: Journal of Cancer
E Deutsch, C Le Péchoux, L Faivre, S Rivera, Y Tao, J-P Pignon, M Angokai, R Bahleda, D Deandreis, E Angevin, C Hennequin, B Besse, A Levy, J-C Soria
BACKGROUND: This phase I study evaluated the safety and efficacy of the oral mTOR inhibitor everolimus in combination with thoracic radiotherapy followed by consolidation chemotherapy in locally advanced or oligometastatic untreated non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS: Everolimus dose was escalated in incremental steps [sequential cohorts of three patients until the occurrence of dose-limiting toxicity (DLT)] and administered orally weekly (weekly group: dose of 10, 20 or 50 mg) or daily (daily group: 2...
June 2015: Annals of Oncology: Official Journal of the European Society for Medical Oncology
J Barinoff, A Traut, D Bauerschlag, J Bischoff, D Herr, K Lübbe, H-J Lück, N Maass, C Mundhenke, M Schmidt, K Schwedler, M Thill, J Steffen, S Loibl, G von Minckwitz
Aim: Around half of all women in Germany with breast cancer are older than 65 and approximately one third of them is older than 70 years of age. In theory, the preferred therapeutic management of women with breast cancer aged 65 and above corresponds to that formulated for younger patients and complies with the S3 Guidelines and the therapy recommendations formulated by AGO. To study the current therapies used to treat women with breast cancer aged 70 and above in Germany, a survey of the clinics of the German Breast Group (GBG) was done...
May 2013: Geburtshilfe und Frauenheilkunde
Mustafa M Mohammad, Kostas N Syrigos, M Wasif Saif
Vinorelbine (Navelbine, VRL) is commonly used for platinum-resistant ovarian cancer and has been shown to be effective in patients with recurrent primary peritoneal carcinoma. Of VRL's major side effects, skin rash is uncommon, and, if it does occur, it is usually localized to site of injection. In this case report, a 71-year-old Hispanic female with primary peritoneal carcinoma received single agent VRL as fourth-line regimen, which she tolerated very well except for a skin rash related to VRL. The rash continued to progress throughout 6 cycles of VRL, and follow-up CT/PET scan demonstrated complete metabolic and radiological responses...
2013: Case Reports in Dermatological Medicine
Runbo Zhong, Baohui Han, Hua Zhong
Dendritic cells (DC) play a crucial role in the induction of an effective antitumor immune response. Cytokine-induced killer (CIK) cells, a subset of T lymphocytes, have the capacity to eliminate cancer cells. This study was to evaluate the correlation between the frequency of DC/CIK immunotherapies following regular chemotherapy, the time-to-progression (TTP), and overall survival (OS) of advanced non-small lung cancer patients. Sixty patients with IIIB-IV non-small-cell lung carcinoma (NSCLC) were enrolled from August 2007 to December 2009 and were randomized into two groups...
February 2014: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
T Brown, G Pilkington, A Bagust, A Boland, J Oyee, C Tudur-Smith, M Blundell, M Lai, C Martin Saborido, J Greenhalgh, Y Dundar, R Dickson
BACKGROUND: The National Institute for Health and Care Excellence (NICE) has issued multiple guidance for the first-line management of patients with lung cancer and recommends different combinations of chemotherapy treatments. This review provides a synthesis of clinical effectiveness and cost-effectiveness evidence supporting current guidance. OBJECTIVES: To evaluate the clinical effectiveness and cost-effectiveness of first-line chemotherapy currently licensed in Europe and recommended by NICE, for adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC)...
July 2013: Health Technology Assessment: HTA
Jiao-qi Wang, Zhen-wu Du, Xian-fei Gao, Mei Wu, Yu-cheng Zhang, Ying Pan, Qian Wang, Gui-zhen Zhang
OBJECTIVE: To investigate the effects of miRNA-mediated down-regulation of the Bcl-2 gene on the chemotherapeutic sensitivities and mRNA transcriptions of sensitivity associated genes in human lung adenocarcinoma cell line A549 cells, and therefore to provide experimental data for improving the chemotherapeutic effects on non-small cell lung cancer (NSCLC). METHODS: The miRNA recombinant plasmid targeting to human Bcl-2 gene was designed, synthesized and stably transferred into A549 cells by lipofectin technique as the experiment group...
March 2013: Chinese Journal of Tuberculosis and Respiratory Diseases
Yanzhen Li, Wenxian Jin, Hui Yan, Huan Liu, Chenggang Wang
In order to reduce the severe venous toxicity, we developed an intravenous lipid emulsion of vinorelbine and investigated its preclinical stability, toxicity and antitumor efficacy. Vinorelbine-phospholipid complex was prepared to enhance the lipophilicity of vinorelbine thus facilitating the encapsulation into lipid emulsion. After complexation more than 70% of vinorelbine was encapsulated into the oil phase. Meanwhile, the lipid emulsion showed good stability without drug leakage. Local irritation after injection of the lipid emulsion was investigated in rabbits and compared with Navelbine(®) (the commercial product)...
September 15, 2013: International Journal of Pharmaceutics
Hong Jiang, Xin-Ming Yu, Xing-Ming Zhou, Xiao-Hong Wang, Dan Su
The aim of this study was to explore the correlation between mRNA expression of β-tubulin-III and stathmin in patients with stage II non-small cell lung cancer (NSCLC) and the chemosensitivity to Navelbine plus cisplatin (NP), as well as to provide a basis for personalized treatment. A single-gene quantitative test was performed to detect the mRNA expression of β-tubulin-III and stathmin in the tumor tissue of patients with stage II NSCLC. All the patients underwent NP treatment following surgery and were followed-up to record their disease-free survival (DFS) and overall survival (OS)...
May 2013: Experimental and Therapeutic Medicine
Qu-Fei Zhang, Li-Xia Li, Guo-Hua Lin, Li-Zhu Lin
OBJECTIVE: To observe the effect of direct moxibustion at Sihua points on immune function and life quality of chemotherapy patients with non-small cell lung cancer. METHODS: Eighty cases were randomly divided into a chemotherapy and moxibustion group (group A) and a chemotherapy group (group B), 40 cases in each one. Navelbine and cisplatin were applied in both groups. In addition, direct moxibustion at Sihua points which included Geshu (BL 17) and Danshu (BL 19) was used in the group A...
March 2013: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
Jaime Alberto Coronel, Lucely del Carmen Cetina, David Cantú, Oscar Cerezo, Cintia Sánchez Hernández, Lesbia Rivera, Adela Poitevin Chacón, Alfonso Duenas-Gonzalez
OBJECTIVE: Chemoradiation with cisplatin is considered the standard of care for patients with locally advanced cervical cancer; however, cisplatin could be difficult to use in aged patients or patients with comorbidities such as diabetes mellitus and blood hypertension; hence, it is important to investigate nonplatinum drugs for radiosensitization. In addition, oral cytotoxics may overcome the drawbacks of intravenous infusions and could be of easier administration. METHODS: In this small randomized trial, we tested cisplatin against oral vinorelbine as radiosensitizers in these patients...
June 2013: International Journal of Gynecological Cancer
Noha Ibrahim, Enas Abou-Elela, Dalia Darwish
BACKGROUND: This study was to evaluate the survival of patients with pleural and intraperitoneal malignant mesothelioma and to investigate the efficacy of chemotherapy (CT) as well as radiotherapy (RTH) and surgery compared to best supportive care (BSC). MATERIALS AND METHODS: Forty patients with malignant mesothelioma (38 with pleural and 2 with intraperitoneal) were enrolled. Twenty seven patients underwent (CT) chemotherapy of which 2 also received (RTH) and surgery was only for biopsy in 15/40...
2013: Asian Pacific Journal of Cancer Prevention: APJCP
H Meden
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December 2002: Onkologie
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