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Esophagogastric junction cancer

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https://www.readbyqxmd.com/read/29791425/-endoscopic-submucosal-dissection-of-a-transpyloric-early-gastric-c%C3%A3-ncer-a-case-report-and-literature-review
#1
Juan Antonio Chirinos Vega, César García Delgado, Alfonso Delgado Vergara
The endoscopic sumucosal disection (ESD) is an advanced endoscopic technique that achieves the curative resection of superficial neoplasms of the gastrointestinal tract, getting block exeresis with margins free of neoplasia avoiding surgery. However, tumors located in the esophagogastric junction, or pylorus, are technically more complex to resect by ESD. When a neoplasm settles in the pylorus, the anatomical characteristics of this region can affect the adequate assessment of the margins and the performance of the procedure...
January 2018: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/29790358/-esophagogastric-junction-and-its-tumours-comments-to-definition-and-classification
#2
Petr Lochman, Tomáš Dušek, Jiří Páral
In spite of the worldwide decreasing incidence of gastric cancer the number of esophagogastric junction and proximal third of stomach carcinomas has been gradually growing up. The reason of that is an increasing incidence of reflux esophagitis with Barrett´s metaplasia and a successful eradication of Helicobacter pylori infection. The aim of this work is to provide various views on definition of the esophagogastric junction and to give an overview of tumours classification schemes being used.
2018: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/29743108/-18-fdg-pet-ct-identifies-histopathological-non-responders-after-neoadjuvant-chemotherapy-in-locally-advanced-gastric-and-cardia-cancer-cohort-study
#3
Paul M Schneider, Dilmurodjon Eshmuminov, Tamara Rordorf, Diana Vetter, Patrick Veit-Haibach, Achim Weber, Peter Bauerfeind, Panagiotis Samaras, Kuno Lehmann
BACKGROUND: Pathologic response to neoadjuvant chemotherapy (neoCTX) is a prognostic factor in many cancer types, and early prediction would help to modify treatment. In patients with gastric and esophagogastric junction (AEG) cancer, the accuracy of FDG PET-CT to predict early pathologic response after neoadjuvant chemotherapy (neoCTX) is currently not known. METHODS: From a consecutive cohort of 72 patients, 44 patients with resectable, locally-advanced gastric cancer or AEG Siewert type II and III received neoCTX after primary staging with endoscopic ultrasound, PET-CT and laparoscopy...
May 9, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29725401/rapid-progression-of-a-granulocyte-colony-stimulating-factor-producing-liver-tumor-metastasized-from-esophagogastric-junction-cancer-a-case-report-and-literature-review
#4
Sojun Hoshimoto, Nobuo Hoshi, Iwao Ozawa, Moriaki Tomikawa, Hirofumi Shirakawa, Takeshi Fujita, Saho Wakamatsu, Sayuri Hoshi, Kaoru Hirabayashi, Shoichi Hishinuma, Yoshiro Ogata
The current study presents the case of a 72-year-old woman with a rapidly enlarged liver metastasis from esophagogastric junction (EGJ) cancer, accompanied by progressive leukocytosis (47,680/µl) and elevated serum granulocyte colony-stimulating factor (G-CSF; 779 pg/ml). The patient underwent right hemihepatectomy 26 months after a total gastrectomy. On the seventh post-operative day the patient's leukocyte count and serum G-CSF level decreased to 4,280/µl and ≤19.5 pg/ml, respectively. Histologically, the lesion was a well to moderately differentiated adenocarcinoma similar to the primary lesion...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29685755/surgery-for-metastases-for-esophageal-gastric-cancer-in-the-real-world-data-from-the-agamenon-national-registry
#5
Alberto Carmona-Bayonas, Paula Jiménez-Fonseca, Isabel Echavarria, Manuel Sánchez Cánovas, Gema Aguado, Javier Gallego, Ana Custodio, Raquel Hernández, Antonio Viudez, Juana María Cano, Eva Martínez de Castro, Ismael Macías, Alfonso Martín Carnicero, Marcelo Garrido, Monserrat Mangas, Felipe Álvarez Manceñido, Laura Visa, Aitor Azkarate, Avinash Ramchandani, Ana Fernández Montes, Federico Longo, Ana Sánchez, Paola Pimentel, María Luisa Limón, David Arias, Diego Cacho Lavin, Rodrigo Sánchez Bayona, Paula Cerdá, Pilar García Alfonso
INTRODUCTION: The effect of surgery for metastases in patients with esophagogastric cancer is unknown, given the lack of randomized clinical trials; likewise, the criteria for selecting eligible patients remain to be determined. METHODS: This registry evaluates the results of patients with advanced adenocarcinoma of the stomach, distal esophagus, or gastro-esophageal junction from 32 centers. To assess selection criteria and prognostic factors, a state arrival extended Markov proportional hazards (PH) model was used...
March 31, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29666800/strategies-of-nodal-staging-of-the-tnm-system-for-esophageal-cancer
#6
REVIEW
Wen-Ping Wang, Song-Lin He, Yu-Shang Yang, Long-Qi Chen
The 8th edition of UICC/AJCC TNM staging for esophageal cancer will start in use since 2018. The nodal staging in this version of TNM system remains unchanged from the 7th edition that based on the number of lymph nodes (LN) involved, except the limited revision of the regional LN map. In this review, N staging revision was evaluated from its initially simple definition of negative (N0) and positive (N1) LN(s) to the current positive node number based proposal. Meanwhile the disadvantages of current N staging were discussed...
February 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29662932/combined-extensive-esophageal-squamous-papillomas-and-florid-cardiac-gland-hyperplasia-in-a-patient-with-adenocarcinoma
#7
Takanori Suganuma, Han-Seung Yoon
We report a rare case of extensive esophageal squamous papillomas (ESPs) involving the entire esophagus and florid cardiac gland hyperplasia involving only the lower esophagus in a 39-year-old woman with heartburn and epigastric distress for the past 2 years. Previous esophagogastroduodenoscopy showed multiple ESPs involving the entire esophagus extending 38 cm from the esophageal orifice to the esophagogastric junction (EGJ). Additionally, prominent cardiac gland hyperplasia over the esophageal posterior wall was exhibited extending 12 cm from the mid-esophagus to the EGJ...
March 2018: GE Portuguese Journal of Gastroenterology
https://www.readbyqxmd.com/read/29660156/evaluation-of-symptomatic-esophagogastric-junction-outflow-obstruction
#8
Andrew Ming Liang Ong, Vikneswaran Namasivayam, Yu Tien Wang
BACKGROUND: Esophagogastric junction outflow obstruction (EGJOO) may be due to anatomical abnormalities but it is unclear how to evaluate them after high resolution manometry (HRM). We aimed to determine 1) clinical and HRM parameters differentiating anatomical EGJOO from functional EGJOO, 2) investigations chosen and yield for anatomical EGJOO and 3) clinical outcomes of functional EGJOO. METHODS: Medical records of consecutive patients with symptomatic EGJOO from February 2012 to December 2015 were reviewed...
April 16, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29650836/-a-case-of-advanced-esophagogastric-junction-cancer-responding-to-s-1-neoadjuvant-chemotherapy
#9
Junko Kuroda, Hisae Aoki, Naoko Kondou, Toshiyuki Sumita, Kei Itoh, Senichirou Agawa
A 56-year-old man was diagnosed with advanced adenocarcinoma of the esophagogastric junction. He received 1 course of neoadjuvant chemotherapy with S-1. After neoadjuvant chemotherapy, the primary tumor showed a remarkable decrease in size. Subtotalesophagectomy, D2 lymph node dissection, and reconstruction with a gastric tube through the posterior mediastinal route were performed. Pathological examination showed that most of the cancer cells had been destroyed, with a part where adenocarcinoma mucosa was seen...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29643292/-a-case-of-postoperative-recurrent-gastric-cancer-resembling-esophageal-achalasia-diagnosed-by-staging-laparoscopy
#10
Masayuki Kabayama, Fumisato Sasaki, Hidehito Maeda, Shiho Arima, Shiroh Tanoue, Yuichiro Nasu, Shinichi Hashimoto, Shuji Kanmura, Jun Kadono, Akio Ido
A 65-year-old man underwent subtotal gastrectomy for advanced gastric cancer. The histological type of the cancer was signet-ring cell carcinoma, and the clinical stage was stage IB (T2N0M0). Three years after surgery, the patient had the following symptoms:dysphagia, odynophagia, and weight loss. Esophageal endoscopy and esophagography revealed a circular stenosis covered with the normal mucosa between the middle esophagus and the esophagogastric junction. Histologically, the samples obtained by staging laparoscopy revealed signet-ring cell carcinoma...
2018: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/29577671/prognostic-significance-of-nfia-and-nfib-in-esophageal-squamous-carcinoma-and-esophagogastric-junction-adenocarcinoma
#11
Bo Yang, Zhi-Hang Zhou, Li Chen, Xiang Cui, Jun-Yan Hou, Kai-Jie Fan, Si-Hao Han, Peng Li, Shao-Qiong Yi, Yang Liu
The nuclear factor I (NFI) family members, especially NFIA and NFIB, play essential roles in cancers. The roles of NFIA and NFIB in esophageal squamous cell carcinoma (ESCC) and esophagogastric junction adenocarcinoma (EJA) remain poorly known. This study aimed to determine the expression of NFIA and NFIB in ESCC and EJA and elucidate their prognostic significance. The expression of NFIA and NFIB was examined in 163 ESCC samples and 26 EJA samples by immunohistochemistry. The results showed that high NFIA expression correlated significantly with poor differentiation, lymph node metastasis, and advanced TNM stage in patients with ESCC...
March 25, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29539629/treatment-outcomes-of-endoscopic-submucosal-dissection-for-adenocarcinoma-originating-from-long-segment-barrett-s-esophagus-versus-short-segment-barrett-s-esophagus
#12
Tomoki Shimizu, Junko Fujisaki, Masami Omae, Akira Yamasaki, Yusuke Horiuchi, Akiyoshi Ishiyama, Toshiyuki Yoshio, Toshiaki Hirasawa, Yorimasa Yamamoto, Tomohiro Tsuchida
BACKGROUND: In recent years, effective outcomes of endoscopic submucosal dissection (ESD) for esophagogastric junction cancer including short-segment Barrett's esophagus (SSBE) cancer have been reported. However, the efficacy of ESD for long-segment Barrett's esophagus (LSBE) cancer is unknown. AIM: To clarify the treatment outcomes of ESD for LSBE cancer versus SSBE cancer. METHODS: A total of 86 patients with 91 superficial Barrett's esophageal adenocarcinomas who underwent ESD were enrolled; of these, 68 had underlying SSBE and 18 had LSBE...
2018: Digestion
https://www.readbyqxmd.com/read/29492907/-clinical-research-status-of-laparoscopic-total-gastrectomy-in-china
#13
Fenglin Liu, Xinyu Qin
Many retrospective and cohort studies have shown that laparoscopic total gastrectomy(LTG) has advantages of less trauma, quicker recovery and better incision than open total gastrectomy, and is not inferior to laparotomy in safety and the short- and long-term outcomes, so it has been widely applied. However there is still a lack of high level evidence-based basis. At present, several prospective multicenter clinical studies are being carried out in China, Japan and South Korea which have high incidence of gastric cancer to demonstrate the safety and feasibility of LTG and evaluate its long-term outcomes as well...
February 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29480761/eighth-edition-staging-of-thoracic-malignancies-implications-for-the-reporting-pathologist
#14
Andrew G Nicholson, Ming S Tsao, William D Travis, Deepa T Patil, Francoise Galateau-Salle, Mirella Marino, Sanja Dacic, Mary Beth Beasley, Kelly J Butnor, Yasushi Yatabe, Harvey I Pass, Valerie W Rusch, Frank C Detterbeck, Hisao Asamura, Thomas W Rice, Ramon Rami-Porta
Context The Staging and Prognostic Factors Committee of the International Association for the Study of Lung Cancer, in conjunction with the International Mesothelioma Interest Group, the International Thymic Malignancy Interest Group, and the Worldwide Esophageal Cancer Collaboration, developed proposals for the 8th edition of their respective tumor, node, metastasis (TNM) staging classification systems. Objective To review these changes and discuss issues for the reporting pathologist. Data Sources Proposals were based on international databases of lung (N = 94 708), with an external validation using the US National Cancer Database; mesothelioma (N = 3519); thymic epithelial tumors (10 808); and epithelial cancers of the esophagus and esophagogastric junction (N = 22 654)...
May 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29417228/comparison-of-long-term-clinical-outcomes-between-endoscopic-and-surgical-resection-for-early-stage-adenocarcinoma-of-the-esophagogastric-junction
#15
Hyun Ju Kim, Hyunsoo Chung, Sung Kwan Shin, Hyoung-Il Kim, Jun Chul Park, Sang Kil Lee, Woo Jin Hyung, Yong Chan Lee, Sung Hoon Noh
BACKGROUND: The aim of this study was to analyze long-term clinical and oncologic outcomes in patients with early-stage adenocarcinoma of the esophagogastric junction (AEG) managed with either endoscopic resection (ER) or surgery. METHODS: The inclusion criteria were AEG, meeting classic or expanded indications for ER of early gastric cancer, and complete resection. A total of 66 patients with Siewert type II AEG were included (ER group, n = 38; vs. surgery group, n = 28)...
February 7, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29394816/-a-case-of-recurrent-stenosis-after-metallic-stenting-for-esophagogastric-junction-adenocarcinoma-with-peritoneal-metastases
#16
Toshiki Hirakawa, Junya Morimoto, Kazunori Nakazawa, Hironari Miyamoto, Takuma Okada, Chihoko Nobori, Shigeaki Kurihara, En Wang, Naoki Aomatsu, Takehiko Iwauchi, Shigehito Yamagata, Yasutake Uchima, Kazuhiro Takeuchi
A 65-year-old man presented with severe strictures from the esophagogastric junction to the body of the stomach and was histopathologically diagnosed with adenocarcinoma. Computed tomography showed multiple peritoneal metastases. A long, covered metallic stent was placed, and chemotherapy was started. Subsequent granulation from the oral side of the stent caused stricture formation, and a covered stent was also placed. After 8 months, granulation from the oral side of the stent caused recurrent stricture formation...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394811/-a-successful-treatment-for-stage-iii-c-gastric-cancer-with-low-cardiac-function-using-s-1-plus-oxaliplatin-sox-as-a-neoadjuvant-chemotherapy
#17
Takahiro Terashima, Shunji Kawamoto, Kouichi Maekawa, Norimitsu Kuroki
A 83-year-old female, with oppression in her chest, was subjected to type 2 advanced gasteric cancer in esophagogastric junction. Examinations revealed Stage III c of cT4, cN2, cM0. For adopting neoadjuvant chemotherapy, S-1 plus CDDP was not on the list, but S-1 plus oxaliplatin (SOX) was, because massive load of infusion along with the chemotherapy was not appropriate for the patient with low cardiac function. After 2 courses of SOX, the primary tumor as well as metastatic lymph nodes were shown with marked reduction in size by CT scan, which enabled total gastrectomy with D2 lymphadenectomy to be performed as a curative resection, leading to patient living with no recurrence more than 3 years...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394662/-esophagogastric-junction-cancer-resection-with-bilateral-adrenal-metastasis-a-case-report
#18
Sho Toyoda, Atsuo Imagawa, Kouichi Demura, Kurumi Tsuchihashi, Satoshi Okumura, Hiroshi Yasuda, Kansuke Yamamoto, Aya Ito, Naoto Mizumura, Ken Yuu, Hiroshi Tsuchihashi, Masao Ogawa, Masayasu Kawasaki, Masao Kameyama
The patient was a 64-year-old man with esophagogastric junction cancer. We performed right thoracotomy-laparotomy for lower esophageal and cardiac gastric resection, D2 lymphadenectomy, and reconstruction of a gastric tube in October 2011. Histopathology confirmed T4aN1M1(LYM), Stage IV cancer(Japanese Classification of Gastric Carcinoma, 14th edition) with R0 resection. Because of preexisting alcoholic cirrhosis, postoperative chemotherapy was not an option. In March 2014, we performed left adrenalectomy for left adrenal metastasis, and in December 2014, we performed right adrenalectomy for metastasis to the right adrenal gland...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394589/-a-case-of-esophagogastric-junction-adenocarcinoma-with-neuroendocrine-differentiation
#19
Yuto Kitano, Jun Kinoshita, Katsunobu Oyama, Koichi Okamoto, Seisho Sakai, Isamu Makino, Keishi Nakamura, Hironori Hayashi, Masafumi Inokuchi, Tomoharu Miyashita, Hidehiro Tajima, Hiroyuki Takamura, Itasu Ninomiya, Sachio Fushida, Tetsuo Ohta
Gastric cancer rarely contains neuroendocrine component. This mixed tumor is defined as neuroendocrine carcinoma (NEC), mixed adenoneuroendocrine carcinoma(MANEC)and so on according to the WHO classification. We report a patient with esophagogastric junction cancer with neuroendocrine differentiation(NED). The patient was 54-year-old man who diagnosed of esophagogastric junction cancer at the medical examination. Upper gastrointestinal endoscopy revealed a type 3 tumor at esophagogastric junction, and the pathological findings were poorly differentiated adenocarcinoma with focal positivity of chromogranin A...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29393168/endoscopic-submucosal-dissection-for-adenocarcinomas-of-the-esophagogastric-junction
#20
Yasuaki Nagami, Masaki Ominami, Koji Otani, Shuhei Hosomi, Fumio Tanaka, Koichi Taira, Noriko Kamata, Hirokazu Yamagami, Tetsuya Tanigawa, Masatsugu Shiba, Toshio Watanabe, Yasuhiro Fujiwara
BACKGROUND: Adenocarcinoma of the esophagogastric junction (EGJ) is uncommon in Eastern countries, including Japan, but it is believed that the incidence of EGJ adenocarcinoma will increase in Asia in the future due to the decreasing incidence of Helicobacter pylori infection. Endoscopic submucosal dissection (ESD) is a minimally invasive and curative treatment that allows precise pathological assessment. SUMMARY: Magnifying endoscopy with narrow-band imaging may be useful for differential diagnoses and for delineating the cancer margin of EGJ adenocarcinoma, but subsquamous carcinoma extension, which is the invasion of EGJ adenocarcinoma beneath the normal esophageal squamous epithelium, makes it difficult to detect cancer margins of the oral side in ESD for EGJ adenocarcinoma...
2018: Digestion
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