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Quinolones

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https://www.readbyqxmd.com/read/29148915/the-frequency-of-mutations-in-quinolone-resistance-determining-regions-and-plasmid-mediated-quinolone-resistance-in-shigella-isolates-recovered-from-pediatric-patients-in-tehran-iran-an-overlooked-problem
#1
Sajad Yaghoubi, Reza Ranjbar, Mohammad Mehdi Soltan Dallal, Mohammad Hasan Shirazi, Mohammad Kazem Sharifi-Yazdi
Fluoroquinolone (FQ) resistance in clinical isolates of Shigella species has been increasing reported in recent years. This study was carried out to find the mutations within the quinolone resistance-determining regions (QRDRs) and the prevalence of plasmid-mediated quinolone resistance (PMQR) determinants among the clinical isolates of Shigella sp. in Tehran, Iran. A total of 50 Shigella isolates were collected from five teaching therapeutic centers in Tehran, Iran and analyzed for antibiotic susceptibility over a period of 20 months from July 2015 to January 2017...
November 17, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29148878/molecular-characterization-of-fluoroquinolone-resistance-mechanisms-of-campylobacter-isolates-from-duck-meats
#2
Min Kang, Bai Wei, Sung-Woon Choi, Se-Yeoun Cha, Hyung-Kwan Jang
The purpose of this study was to identify the molecular basis of quinolone resistance of Campylobacter isolates recovered from duck meats. Sixty-one isolates from duck meat samples were studied using sequence analysis of the gyrA gene, and PCR assays were used to identify the presence of the CmeABC efflux pump and its restored sensitivity in the presence of efflux-pump inhibitors. High-level resistance to nalidixic acid and ciprofloxacin was attributed to amino acid substitutions Thr-86-Ile in some isolates...
November 17, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/29144766/from-ketones-amines-and-carbon-monoxide-to-4-quinolones-palladium-catalyzed-oxidative-carbonylation
#3
Jiwei Wu, Yuchen Zhou, Ting Wu, Yi Zhou, Chien-Wei Chiang, Aiwen Lei
A novel method of palladium-catalyzed oxidative carbonylation of ketones, amines, and carbon monoxide for the synthesis of 4-quinolones has been developed. This protocol provides a straightforward route to construct useful 4-quinolone derivatives from inexpensive chemicals.
November 16, 2017: Organic Letters
https://www.readbyqxmd.com/read/29140103/salmonella-gallinarum-field-isolates-and-its-relationship-to-vaccine-strain-sg9r
#4
P K V Koerich, B B Fonseca, E Balestrin, V Tagliari, P G Hoepers, C Ueira-Vieira, I Oldoni, R H Rauber, L Ruschel, V P Do Nascimento
1. The aim of the present study was to determine if the 9R-strain of the Salmonella gallinarum live vaccine was responsible for having fowl typhoid outbreaks in chicken flocks from both chicken and turkey breeders as well as to verify the antimicrobial resistance of the isolates from the outbreaks. 2. The triplex polymerase chain reaction (PCR), standard antimicrobial test, beta-lactamase genes identification and Ion Torrent PMG whole genome sequence were used in the field isolates and in the vaccine strain of S...
November 15, 2017: British Poultry Science
https://www.readbyqxmd.com/read/29138963/synthesis-of-novel-tetrazole-containing-hybrid-ciprofloxacin-and-pipemidic-acid-analogues-and-preliminary-biological-evaluation-of-their-antibacterial-and-antiproliferative-activity
#5
Kommula Dileep, Sowjanya Polepalli, Nishant Jain, Sudheer Kumar Buddana, R S Prakasham, M S R Murty
A series of 1-substituted-1H-tetrazole-5-thiol building blocks were synthesized and introduced to the N-4 piperazinyl group at C-7 position of the quinolone core, and these novel compounds (5a-g and 8a-g) were screened for their antibacterial and antiproliferative activities. Bioactive assay studies manifested that most of new compounds exhibited significant antibacterial activity against the tested strains, including multi-drug-resistant MRSA in comparison with reference drugs ciprofloxacin, streptomycin B and pipemidic acid...
November 14, 2017: Molecular Diversity
https://www.readbyqxmd.com/read/29138921/world-trends-for-h-pylori-eradication-therapy-and-gastric-cancer-prevention-strategy-by-h-pylori-test-and-treat
#6
REVIEW
Hidekazu Suzuki, Hideki Mori
Helicobacter pylori-associated gastritis leads to the development of gastric cancer. Kyoto global consensus report on H. pylori gastritis recommended H. pylori eradication therapy to prevent gastric cancer. To manage H. pylori infection, it is important to choose the appropriate regimen considering regional differences in resistance to clarithromycin and metronidazole. Quinolones and rifabutin-containing regimens are useful as third- and fourth-line rescue therapies.
November 14, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29138021/gyra-and-or-parc-alterations-of-haemophilus-influenzae-strains-isolated-from-the-urethra-of-men-with-acute-urethritis
#7
Hiromi Kondo, Shin Ito, Kyoko Hatazaki, Kengo Horie, Keita Nakane, Kosuke Mizutani, Tomohiro Tsuchiya, Mitsuru Yasuda, Shigeaki Yokoi, Masahiro Nakano, Takashi Deguchi
Of 73 clinical strains of Haemophilus influenzae isolated from the urethra of men with urogenital infections, we enrolled 6 strains (8.2%) with levofloxacin (LVFX) minimum inhibitory concentrations (MICs) of ≥0.03 μg/ml in this study. All the strains were isolated from non-gonococcal urethritis (NGU). We amplified the quinolone resistance-determining region of the gyrA gene and the analogous region of the parC gene from bacterial DNAs by PCR and sequenced the PCR products. Two strains with a LVFX MIC of 0...
November 11, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29133912/the-multiple-antibiotic-resistance-operon-of-enteric-bacteria-controls-dna-repair-and-outer-membrane-integrity
#8
Prateek Sharma, James R J Haycocks, Alistair D Middlemiss, Rachel A Kettles, Laura E Sellars, Vito Ricci, Laura J V Piddock, David C Grainger
The multiple antibiotic resistance (mar) operon of Escherichia coli is a paradigm for chromosomally encoded antibiotic resistance in enteric bacteria. The locus is recognised for its ability to modulate efflux pump and porin expression via two encoded transcription factors, MarR and MarA. Here we map binding of these regulators across the E. coli genome and identify an extensive mar regulon. Most notably, MarA activates expression of genes required for DNA repair and lipid trafficking. Consequently, the mar locus reduces quinolone-induced DNA damage and the ability of tetracyclines to traverse the outer membrane...
November 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/29132466/-association-of-drug-resistance-of-mycoplasma-pneumoniae-with-dna-load-and-genotypes-in-children-with-mycoplasma-pneumoniae-pneumonia
#9
Hui-Fen Zhang, Hai-Tao Bai, Ji-Ming Li, Hui Xie, Ye Wang
OBJECTIVE: To investigate the association of drug resistance of Mycoplasma pneumoniae (MP) with DNA load and genotypes in children with MP pneumonia. METHODS: A total of 230 children who were hospitalized and diagnosed with MP pneumonia between January 2012 and December 2016 were enrolled. Throat swabs were collected from the 230 children, and a rapid drug sensitivity assay was used to determine the sensitivity of clinical isolates of MP to nine commonly used antibacterial agents...
November 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29130161/detection-of-2-alkyl-4-quinolones-using-biosensors
#10
Matthew P Fletcher, Stephen P Diggle, Miguel Cámara, Paul Williams
2-Alkyl-4-quinolones (AQs) such as 2-heptyl-3-hydroxy-4-quinolone (PQS) and 2-heptyl-4-hydroxyquinoline (HHQ) are quorum-sensing signal molecules. Here we describe two methods for AQ detection and quantification that employ thin-layer chromatography (TLC) and microtiter plate assays in combination with a lux-based Pseudomonas aeruginosa AQ biosensor strain. For TLC detection, organic solvent extracts of bacterial cells or spent culture supernatants are chromatographed on TLC plates, which are then dried and overlaid with the AQ biosensor...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29130018/virulence-and-antimicrobial-resistance-in-campylobacter-spp-from-a-peruvian-pediatric-cohort
#11
Angela Lluque, Maribel Riveros, Ana Prada, Theresa J Ochoa, Joaquim Ruiz
The presence of virulence factors (VFs) and mechanisms of quinolones and macrolide resistance was analyzed in Campylobacter spp. from a pediatric cohort study in Lima. In 149 isolates (39 Campylobacter jejuni and 24 Campylobacter coli from diarrheic cases; 57 C. jejuni and 29 C. coli from controls), the presence of the cdtABC and cadF genes and iam marker was established. Nalidixic acid, ciprofloxacin, erythromycin, and azithromycin susceptibilities were established in 115 isolates and tetracycline-susceptibility was established in 100 isolates...
2017: Scientifica
https://www.readbyqxmd.com/read/29129066/alcl3-catalyzed-intramolecular-cyclization-of-n-arylpropynamides-with-n-sulfanylsuccinimides-divergent-synthesis-of-3-sulfenyl-quinolin-2-ones-and-azaspiro-4-5-trienones
#12
Wen-Chao Gao, Tao Liu, Yu-Fei Cheng, Hong-Hong Chang, Xing Li, Rong Zhou, Wen-Long Wei, Yan Qiao
Switchable ortho/ipso-cyclization of N-arylpropynamides induced with N-sulfanylsuccinimides as general sulfur reagents is reported. In the presence of MeOH, para-fluoro N-arylpropynamides exclusively undergo the ipso-cyclization to give 3-sulfenyl azaspiro[4,5]trienones. Two kinds of bioactive heterocycle, benzothieno-[3,2-b]quinoline and -[2,3-c]quinolone, have been directly and efficiently prepared from the corresponding sulfenylated products.
November 11, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29126731/synthesis-antibacterial-properties-and-2d-qsar-studies-of-quinolone-triazole-conjugates
#13
Hassan M Faidallah, Adel S Girgis, Anand D Tiwari, Hitesh H Honkanadavar, Sean J Thomas, Ahmed Samir, Atef Kalmouch, Khalid A Alamry, Khalid A Khan, Tarek S Ibrahim, Amany M M Al-Mahmoudy, Abdullah M Asiri, Siva S Panda
A set of 1,2,3-triazole incorporated quinolone antibiotic conjugates 10-15, 17-19 were synthesized via microwave assisted click chemistry technique. Some of the aryl-substituted conjugates 17-19 show promising antibacterial properties against the tested Gram-positive (S. aureus and S. pyogenes) and Gram-negative bacteria (S. typhi) with potency higher than that of the parent antibiotics 1-3. 2D-QSAR modeling supports the observed biological properties.
October 16, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29118308/synthesis-molecular-docking-and-biological-evaluation-of-quinolone-derivatives-as-novel-anticancer-agents
#14
Jie Li, Tu-Cai Zheng, Yi Jin, Jian-Guo Xu, Jian-Gang Yu, Yan-Wen Lv
A series of novel quinolone derivatives (8a-j) were synthesized, and their anticancer activities were tested in human cancer cell lines A549, HL-60, and Hela. Compound 8i was found to be 5-times more potent in cell-killing activity for cell lines A549, HL-60, and Hela than the positive control irinotecan or cisplatin, with IC50 of 0.009, 0.008 and 0.010 μM, respectively. The docking study revealed that compound 8i might have strong interactions with the active site of DNA-Topoisomerase I.
November 9, 2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29113933/spread-of-klebsiella-pneumoniae-st395-non-susceptible-to-carbapenems-and-resistant-to-fluoroquinolones-in-north-eastern-france
#15
Anaëlle Muggeo, Thomas Guillard, Frédéric Klein, Fany Reffuveille, Caroline François, Anamaria Babosan, Odile Bajolet, Xavier Bertrand, Christophe de Champs
Fluoroquinolones (FQ) are potential treatments to treat infections from extended-spectrum β-lactamase producing-Enterobacteriaceae susceptible to FQ. Due to increasing non-susceptibility to carbapenems among Enterobacteriaceae, we characterized FQ resistance mechanisms in 36 Klebsiella pneumoniae isolates that are non-susceptible to ertapenem in North-Eastern France in 2012 and described the population structure by pulsed field gel electrophoresis (PFGE) and multi-locus sequence typing (MLST). Among them, 36% (13/36) carried a carbapenemase encoding-gene...
November 4, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29111483/involvement-of-topoisomerase-mutations-qnr-and-aac-6-ib-cr-genes-in-conferring-quinolone-resistance-to-the-clinical-isolates-of-vibrio-and-shigella-spp-1998-to-2009-from-kolkata-india
#16
Kittappa Vinothkumar, Shaileshkumar R Bhalara, Aneri Shah, Thandavarayan Ramamurthy, Swapan Kumar Niyogi, G Naresh Kumar, Ashima Kushwaha Bhardwaj
BACKGROUND: Quinolone antibiotics have been widely used to treat diarrheal diseases caused by the bacterial agents such as those belonging to Vibrio spp. and Shigella spp. As these pathogens are accumulating quinolone resistance, treating the infections caused by them has become complicated. METHODS AND RESULTS: In this study, isolates of Vibrio and Shigella species, obtained from the diarrhea patients from Kolkata, India were analyzed for quinolone resistance. In total, nine V...
October 27, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29111433/longitudinal-study-on-antimicrobial-consumption-and-resistance-in-rabbit-farming
#17
Fabrizio Agnoletti, Romina Brunetta, Luca Bano, Ilenia Drigo, Elena Mazzolini
Reliable indicators of antimicrobial consumption (AMC) measured with harmonized data and supported with indicators for antimicrobial resistance (AMR) at herd level are necessary to target antimicrobial misuse in food producing animals. To this scope in 2010-2015 we collected AMC data in 32 Italian industrial rabbit holdings weighted with semester production and standardized with animal daily dose (ADD). Herd level AMR against eight antimicrobials was assessed in E. coli, E. faecalis and E. hirae collected in 2014 and 2015...
October 27, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29109700/exploring-the-genome-and-phenotype-of-multi-drug-resistant-klebsiella-pneumoniae-of-clinical-origin
#18
João Anes, Daniel Hurley, Marta Martins, Séamus Fanning
Klebsiella pneumoniae is an important nosocomial pathogen with an extraordinary resistant phenotype due to a combination of acquired resistant-elements and efflux mechanisms. In this study a detailed molecular characterization of 11 K. pneumoniae isolates of clinical origin was carried out. Eleven clinical isolates were tested for their susceptibilities, by disk diffusion and broth microdilution and interpreted according to CLSI guidelines. Efflux activity was determined by measuring the extrusion of ethidium bromide and biofilm formation was assessed following static growth in Müeller-Hinton and minimal media M9 broths at two temperatures and time points...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29107652/association-of-the-exou-genotype-with-a-multidrug-non-susceptible-phenotype-and-mrna-expressions-of-resistance-genes-in-pseudomonas-aeruginosa
#19
Iichiro Takata, Yuka Yamagishi, Hiroshige Mikamo
The increased prevalence of the virulence factor exoU + genotype among multidrug-resistant Pseudomonas aeruginosa has been previously reported. However, the genes that are related to the multidrug resistance of the exoU + genotype strain have not been analyzed and remain to be elucidated. The objective of this study was to analyze the correlations between virulence factors and resistance genes. The exoU + genotype was frequently found in carbapenem and fluoroquinolone non-susceptible strains. The imp carbapenemase genotype, the quinolone-resistance-determining region mutation in GyrA and ParC and the defective mutation in OprD were not frequently found in the exoU + genotype and carbapenem and fluoroquinolone non-susceptible strains...
October 26, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29103680/the-role-of-atp-pools-in-persister-cell-formation-in-fluoro-quinolone-susceptible-and-resistant-strains-of-salmonella-enterica-ser-typhimurium
#20
Sebastian Braetz, Peter Schwerk, Arthur Thompson, Karsten Tedin, Marcus Fulde
In this study, we investigated the reported dependence on the ATP pools for persister cell formation in fluoroquinolone-resistant variants of the facultative intracellular pathogen Salmonella enterica serovar Typhimurium. We compared the generation of persister cell populations after ciprofloxacin challenge of wildtype and a nalidixic acid-resistant variant of S. Typhimurium with reduced ciprofloxacin-susceptibility, as well as strains containing a deletion of the atp operon or harbouring the cloned atp genes...
October 2017: Veterinary Microbiology
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