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neoadjuvant chemoradiotherapy

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https://www.readbyqxmd.com/read/29137264/preoperative-chemoradiotherapy-for-rectal-cancer-the-sensitizer-role-of-the-association-between-mir-375-and-c-myc
#1
Raquel Conde-Muiño, Carlos Cano, Victoria Sánchez-Martín, Antonio Herrera, Ana Comino, Pedro P Medina, Pablo Palma, Marta Cuadros
Administration of chemoradiation before tumor resection has revolutionized the management of locally advanced rectal cancer, but many patients have proven resistant to this preoperative therapy. Our group recently reported a negative correlation between c-Myc gene expression and this resistance. In the present study, integrated analysis of miRNA and mRNA expression profiles was conducted in 45 pre-treatment rectal tumors in order to analyze the expressions of miRNAs and c-Myc and their relationship with clinicopathological factors and patient survival...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29136963/lymph-node-status-after-neoadjuvant-chemoradiotherapy-for-esophageal-cancer-implications-for-the-extent-of-lymphadenectomy
#2
William B Robb, Emilie Maillard, Christophe Mariette
No abstract text is available yet for this article.
December 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29136212/neoadjuvant-and-adjuvant-therapy-for-stage-iii-non-small-cell-lung-cancer
#3
Shun-Ichi Watanabe, Kazuo Nakagawa, Kenji Suzuki, Kazuya Takamochi, Hiroyuki Ito, Jiro Okami, Keiju Aokage, Hisashi Saji, Hiroshige Yoshioka, Yoshitaka Zenke, Tadashi Aoki, Yasuhiro Tsutani, Morihito Okada
The treatments for advanced non-small cell lung cancer (NSCLC) should control both local and microscopic systemic disease, because the 5-year survival of patients with Stage III NSCLC who underwent surgical resection alone has been dismal. One way to improve surgical outcome is the administration of chemotherapy before or after the surgical procedure. During the last two decades, many clinical studies have focused on developing optimal adjuvant or neoadjuvant chemotherapy regimens that can be combined with surgical treatment and/or radiotherapy...
November 9, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29130232/-clinical-study-of-preserving-left-colic-artery-during-laparoscopic-total-mesorectal-excision-for-the-treatment-of-rectal-cancer
#4
Xiaolan You, Yuanjie Wang, Zhiyi Chen, Wenqi Li, Ning Xu, Guiyuan Liu, Xiaojun Zhao, Chuanjiang Huang
OBJECTIVE: To evaluate the feasibility, safety, radicality and short-term outcome of preserving left colic artery (LCA) during laparoscopic total mesorectal excision (TME) for the treatment of rectal cancer. METHODS: From January 2013 to December 2016,136 patients with mid-lower rectal cancer received laparoscopic TME in the Gastrointestinal Surgery Department of Taizhou People's Hospital of Jiangsu Province. Patients with rectal tumor within 10 cm to the anal verge were enrolled into the study...
October 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29128908/cetuximab-tpf-radiotherapy-in-oesophageal-cancer
#5
Maria Alsina, Fernando Rivera, Francisco Javier Ramos, Maica Galán, Rafael López, Pilar García-Alfonso, José Enrique Alés-Martinez, Bernardo Queralt, Antonio Antón, Alfredo Carrato, Cristina Grávalos, Maria José Méndez-Vidal, Carlos López, Inmaculada Ruiz de Mena, Josep Tabernero, Jordi Giralt, Enrique Aranda
BACKGROUND: Pre-operative chemoradiotherapy using a 5-fluorouracil (5-FU)/cisplatin backbone is widely used to improve surgical outcomes in locoregional oesophageal cancer patients, despite a non-negligible failure rate. OBJECTIVE: We evaluated intensification of this approach to improve patient outcomes by adding cetuximab to induction 5-FU/cisplatin/docetaxel (TPF) and to chemoradiotherapy in a phase II study. PATIENTS AND METHODS: Between November 2006 and April 2009, 50 patients with stage II-IVa squamous cell carcinoma (SCC) or adenocarcinoma of the oesophagus or gastro-oesophageal junction initiated three TPF/cetuximab cycles...
November 11, 2017: Targeted Oncology
https://www.readbyqxmd.com/read/29126244/impact-of-neoadjuvant-chemoradiotherapy-on-health-related-quality-of-life-in-long-term-survivors-of-esophageal-or-junctional-cancer-results-from-the-randomized-cross-trial
#6
B J Noordman, M G E Verdam, S M Lagarde, J Shapiro, M C C M Hulshof, M I van Berge Henegouwen, B P L Wijnhoven, G A P Nieuwenhuijzen, J J Bonenkamp, M A Cuesta, J Th M Plukker, E J Spillenaar Bilgen, E W Steyerberg, A van der Gaast, M A G Sprangers, J J B van Lanschot
Background: Neoadjuvant chemoradiotherapy (nCRT) plus surgery is a standard of care for patients with esophageal or junctional cancer, but the long-term impact of nCRT on health-related quality of life (HRQOL) is unknown. The purpose of this study is to compare very long-term HRQOL in long-term survivors of esophageal cancer who received nCRT plus surgery or surgery alone. Patients and methods: Patients were randomly assigned to receive nCRT (carboplatin/paclitaxel with 41...
November 6, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29125080/-organ-sparing-treatment-in-oesophagus-cancer-feasible-and-safe
#7
B J Noordman, B P L Wijnhoven, S M Lagarde, M C W Spaander, R Valkema, J J B van Lanschot
In many countries, neoadjuvant chemoradiotherapy (nCRT) plus surgery is standard treatment for resectable oesophageal cancer. After nCRT, up to 30% of all patients have no residual disease in the resection specimen. Consequently, an active surveillance approach, in which patients undergo frequent clinical investigations after nCRT instead of standard oesophagectomy, is increasingly applied in selected patients. Here, we describe outcomes for three patients who underwent active surveillance. A 63-year old woman was considered unfit for surgery after nCRT...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29124955/current-issues-of-preoperative-radio-chemo-therapy-and-its-future-evolution-in-locally-advanced-rectal-cancer
#8
Bin Ma, Qingzhou Xu, Yongxi Song, Peng Gao, Zhenning Wang
Neoadjuvant therapies are effective for local control and tumor downstaging. Up to date, preoperative long-course chemoradiotherapy and short-course radiotherapy are the two primary guideline-recommended neoadjuvant therapies for locally advanced rectal cancer patients. However, clinicians throughout the world are trying their best to further optimize the regimens and concepts of neoadjuvants. Hence, there is an urgent need to summarize evidence regarding indications of neaoadjuvant therapies and relative merits of current standard regimens...
November 10, 2017: Future Oncology
https://www.readbyqxmd.com/read/29119525/haralick-s-texture-features-for-the-prediction-of-response-to-therapy-in-colorectal-cancer-a-preliminary-study
#9
Damiano Caruso, Marta Zerunian, Maria Ciolina, Domenico de Santis, Marco Rengo, Mumtaz H Soomro, Gaetano Giunta, Silvia Conforto, Maurizio Schmid, Emanuele Neri, Andrea Laghi
PURPOSE: Haralick features Texture analysis is a recent oncologic imaging biomarker used to assess quantitatively the heterogeneity within a tumor. The aim of this study is to evaluate which Haralick's features are the most feasible in predicting tumor response to neoadjuvant chemoradiotherapy (CRT) in colorectal cancer. MATERIALS AND METHODS: After MRI and histological assessment, eight patients were enrolled and divided into two groups based on response to neoadjuvant CRT in complete responders (CR) and non-responders (NR)...
November 8, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/29114597/neoadjuvant-twice-daily-chemoradiotherapy-for-esophageal-cancer-treatment-related-mortality-and-long-term-outcomes
#10
Stuart E Samuels, Matthew H Stenmark, Jae Y Lee, Jonathan B McHugh, James A Hayman, Mark B Orringer, Susan G Urba, Libin Sun, Congying Xie, Feng-Ming Kong, Kyle C Cuneo
Objective: Because of the short potential doubling time of esophageal cancer, there is a theoretical benefit to using an accelerated radiation treatment schedule. This study evaluates outcomes and treatment-related mortality and morbidity of patients treated with neoadjuvant hyperfractionated accelerated chemoradiation for resectable esophageal cancer. Methods and materials: Outcomes from 250 consecutive patients with resectable esophageal cancer treated with preoperative hyperfractionated accelerated chemoradiotherapy (45 Gy in 30 twice-daily fractions over 3 weeks) followed by planned transhiatal esophagectomy were analyzed...
July 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29113729/intensified-neoadjuvant-chemoradiotherapy-for-locally-advanced-rectal-cancer-in-elderly-patients-toxicity-disease-control-and-survival-outcomes
#11
Francesca De Felice, Karen Llange, Filippo Rubini, Nadia Bulzonetti, Rossella Caiazzo, Daniela Musio, Vincenzo Tombolini
INTRODUCTION: We report the treatment compliance, toxicity rates, and long-term clinical outcomes of elderly patients who received intensified neoadjuvant chemoradiotherapy (CRT) for locally advanced rectal cancer (LARC). PATIENTS AND METHODS: We identified a retrospective cohort of patients aged ≥ 70 years with LARC who received intensified neoadjuvant CRT, followed by surgery and adjuvant chemotherapy, from 2007 to 2014. Intensified neoadjuvant CRT consisted of radiotherapy (total dose, 50...
October 16, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/29113673/esophageal-adenocarcinoma-stage-iii-survival-based-on-pathological-response-to-neoadjuvant-treatment
#12
Katrin Schwameis, Joerg Zehetner, Jeffrey A Hagen, Daniel S Oh, Stephanie G Worrell, Kais Rona, Nathan Cheng, Jamil Samaan, Kyle M Green, John C Lipham
BACKGROUND: Neoadjuvant chemoradiotherapy is the standard treatment for locally advanced esophageal adenocarcinomas (EAC). Pathological response is thought to be a major prognostic factor. Aims of this study were to determine the frequency of complete response and to compare the survival of complete and incomplete responders in stage III EAC. METHODS: A retrospective review was performed of all stage III patients that underwent neoadjuvant therapy followed by esophagectomy between 1999 and 2015...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29108299/serum-mir-143-levels-predict-the-pathological-response-to-neoadjuvant-chemoradiotherapy-in-patients-with-locally-advanced-rectal-cancer
#13
Yukiharu Hiyoshi, Takashi Akiyoshi, Ramu Inoue, Keiko Murofushi, Noriko Yamamoto, Yosuke Fukunaga, Masashi Ueno, Hideo Baba, Seiichi Mori, Toshiharu Yamaguchi
Recently, several circulating miRNAs have been reported as promising, minimally invasive biomarkers for the diagnosis or prediction of the prognosis in various types of cancer. However, the utility of circulating miRNAs as predictive markers of the cancer response to neoadjuvant chemoradiotherapy (nCRT) for locally advanced rectal cancer is still unclear. To identify circulating serum miRNAs useful for predicting a pathological good response to nCRT, total 18 serum miRNAs of interest were analyzed by real-time polymerase chain reaction in 94 rectal cancer patients treated with nCRT and surgery...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29104590/impact-of-body-mass-index-on-surgical-and-oncological-outcomes-in-laparoscopic-total-mesorectal-excision-for-locally-advanced-rectal-cancer-after-neoadjuvant-5-fluorouracil-based-chemoradiotherapy
#14
Yanwu Sun, Pan Chi
Aims: To evaluate the impact of body mass index (BMI) on the surgical outcome of laparoscopic total mesorectal excision (laTME) for locally advanced rectal cancer (LARC, clinically staged as UICC stage II/III) after neoadjuvant chemoradiotherapy (nCRT). Methods: 312 LARC patients undergoing laTME after nCRT were divided into nonobese (BMI < 25.0 kg/m(2), n = 249) and obese (BMI ≥ 25.0 kg/m(2), n = 63) groups. Preoperative radiotherapy was delivered in 45-50...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/29102233/rectal-perfusion-parameters-normalised-to-tumour-free-rectal-wall-can-predict-response-to-neoadjuvant-chemoradiotherapy
#15
S Krishan, A Patel, R Sud, R Puri, A Vaid, L Lipi, T Kataria
AIMS: To evaluate absolute changes in quantitative and semi-quantitative perfusion parameters using a newer approach of comparing these parameters with tumour-free normal rectal wall (i.e., relative/normalised change) in predicting complete pathological response to chemoradiotherapy. MATERIALS AND METHODS: Perfusion parameters measured before and after treatment of 10 patients with histopathologically proven rectal cancer that showed complete treatment response (Group 1) were compared with 10 patients with residual tumour on histopathology following treatment (Group 2)...
October 25, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/29101570/transanal-total-mesorectal-excision-pathological-results-of-186-patients-with-mid-and-low-rectal-cancer
#16
F Borja de Lacy, Jacqueline J E M van Laarhoven, Romina Pena, María Clara Arroyave, Raquel Bravo, Miriam Cuatrecasas, Antonio M Lacy
BACKGROUND: Transanal total mesorectal excision (TaTME) seems to be a valid alternative to the open or laparoscopic TME. Quality of the TME specimen is the most important prognostic factor in rectal cancer. This study shows the pathological results of the largest single-institution series published on TaTME in patients with mid and low rectal cancer. METHODS: We conducted a retrospective cohort study of all consecutive patients with rectal cancer, treated by TaTME between November 2011 and June 2016...
November 3, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29100742/outcome-of-neoadjuvant-chemoradiation-in-mri-staged-locally-advanced-rectal-cancer-retrospective-analysis-of-123-chinese-patients
#17
Shing Fung Lee, Chi Leung Chiang, Francis Ann Shing Lee, Yiu Wah Wong, Chi Ming Poon, Frank Chi Sing Wong, Stewart Yuk Tung
BACKGROUND: For advanced rectal cancer with involved or threatened mesorectal fascia (MRF), current standard is pre-operative long course chemoradiotherapy (PLCRT) with either capecitabine or 5-fluorouracil (5-FU). However, few Chinese data on its clinical outcome are available, especially for those with pelvic MRI staging. METHODS: Between Jan-2009 and Oct-2014, 123 consecutive patients with biopsy proven adenocarcinoma of rectum, all with pelvic MRI staging, selected for PLCRT after multi-disciplinary team discussion were recruited...
November 1, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29095283/experience-of-weekly-cisplatin-concurrent-with-intensity-modulated-radiotherapy-for-locally-advanced-nasopharyngeal-carcinoma-patients-with-resistance-to-neoadjuvant-chemotherapy
#18
Chuanben Chen, Taojun Chen, Chaoxiong Huang, Jing Wang, Zhaodong Fei
Nasopharyngeal carcinoma (NPC) is highly sensitive to radiotherapy. Locally advanced NPC has a relatively poor prognosis if treated with radiotherapy alone. Several studies have demonstrated that chemoradiotherapy confers survival benefit in locally advanced NPC. However, a small proportion of patients are resistant to chemotherapy based on cisplatin. So, it is important to make a valuable and inexpensive schedule for these patients. After 2 cycles of neoadjuvant chemotherapy that consisted of gemcitabine and cisplatin (80 mg/m, every 3 weeks) or paclitaxel and cisplatin (80 mg/m, every 3 weeks), magnetic resonance imaging (MRI) was used to evaluate efficacy...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29094083/neoadjuvant-chemotherapy-with-capecitabine-plus-cisplatin-in-patients-with-locally-advanced-nasopharyngeal-cancer-case-series-study
#19
Reyad Dada, Mohamed El Sayed, Jamal Zekri
Purpose: Capecitabine, an oral fluorouracil (5-FU) derivative, has replaced 5-FU in many chemotherapy regimens used in various GI tract cancers. The experience with capecitabine in nasopharyngeal carcinoma (NPC) is limited. Patients and Methods: We report on eight patients with locally advanced NPC treated with neoadjuvant chemotherapy with capecitabine and cisplatin. Results: All eight patients responded well to the chemotherapy combination and achieved complete remission after definitive chemoradiotherapy...
October 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/29080946/treatment-results-of-neoadjuvant-chemoradiotherapy-followed-by-radical-esophagectomy-in-patients-with-initially-inoperable-thoracic-esophageal-cancer
#20
Hideyuki Morimoto, Yushi Fujiwara, Shigeru Lee, Kosuke Amano, Masako Hosono, Yukio Miki, Harushi Osugi
PURPOSE: We evaluated the effectiveness of neoadjuvant chemoradiotherapy (CRT) followed by esophagectomy for cT4 esophageal cancer or lymph node metastases (LNM) invading adjacent structures. MATERIALS AND METHODS: We retrospectively evaluated 42 consecutive patients with thoracic esophageal cancer who underwent CRT followed by esophagectomy between 2008 and 2013. All were initially considered to be unresectable because of cT4 (n = 32) disease or LN invasion (n = 10)...
October 28, 2017: Japanese Journal of Radiology
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