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Beta1 adrenergic receptor

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https://www.readbyqxmd.com/read/27754210/os-31-02-antihypertensive-response-to-bisoprolol-was-not-related-to-polymorphisms-in-adrb1-or-cyp2d6-in-chinese-hypertensive-patients
#1
Weiwei Zeng, Tanya Chu, Miao Hu, Alice Kong, Brian Tomlinson
OBJECTIVE: The blood pressure (BP) response to antihypertensive drugs varies considerably between different patients. The response to some beta-blockers has been associated with polymorphisms in the beta1-adrenergic receptor (ADRB1) or cytochrome P450 2D6 (CYP2D6) genes. We examined the effects of common polymorphisms in ADRB1 and CYP2D6 on the response to bisoprolol in 100 Chinese patients. DESIGN AND METHOD: Chinese patients with primary hypertension with sitting clinic systolic BP (SBP) 140-169 mmHg and/or diastolic BP (DBP) 90-109 mmHg after placebo run-in were treated with open-label bisoprolol 2...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27643167/os-31-02-antihypertensive-response-to-bisoprolol-was-not-related-to-polymorphisms-in-adrb1-or-cyp2d6-in-chinese-hypertensive-patients
#2
Weiwei Zeng, Tanya Chu, Miao Hu, Alice Kong, Brian Tomlinson
OBJECTIVE: The blood pressure (BP) response to antihypertensive drugs varies considerably between different patients. The response to some beta-blockers has been associated with polymorphisms in the beta1-adrenergic receptor (ADRB1) or cytochrome P450 2D6 (CYP2D6) genes. We examined the effects of common polymorphisms in ADRB1 and CYP2D6 on the response to bisoprolol in 100 Chinese patients. DESIGN AND METHOD: Chinese patients with primary hypertension with sitting clinic systolic BP (SBP) 140-169 mmHg and/or diastolic BP (DBP) 90-109 mmHg after placebo run-in were treated with open-label bisoprolol 2...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27437032/visceral-adiposity-syndrome
#3
REVIEW
Heno F Lopes, Maria Lúcia Corrêa-Giannella, Fernanda M Consolim-Colombo, Brent M Egan
The association of anthropometric (waist circumference) and hemodynamic (blood pressure) changes with abnormalities in glucose and lipid metabolism has been motivation for a lot of discussions in the last 30 years. Nowadays, blood pressure, body mass index/abdominal circumference, glycemia, triglyceridemia, and HDL-cholesterol concentrations are considered in the definition of Metabolic syndrome, referred as Visceral adiposity syndrome (VAS) in the present review. However, more than 250 years ago an association between visceral and mediastinal obesity with hypertension, gout, and obstructive apnea had already been recognized...
2016: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/27416924/sympathectomy-reduces-tumor-weight-and-affects-expression-of-tumor-related-genes-in-melanoma-tissue-in-the-mouse
#4
Lubica Horvathova, Alexandra Padova, Andrej Tillinger, Jana Osacka, Jozef Bizik, Boris Mravec
Accumulated evidence indicates that sympathetic nerves may potentiate tumor growth, including melanoma. To elucidate possible mechanisms for this effect, we performed chemical sympathectomy by intraperitoneal (i.p.) injection of the neurotoxin 6-hydroxydopamine hydrobromide (100 mg/kg of body weight); in nine adult male C57BL/6J mice; nine control mice received i.p. vehicle (VEH). Seven days later, all mice were injected subcutaneously with 3 × 10(3) B16-F10 melanoma cells. Mice were euthanized 20 d after injection of melanoma cells, for measurement of tumor weight and expression of genes related to sympathetic signaling, apoptosis, hypoxia and angiogenesis in tumor tissue...
September 2016: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/27373953/somatic-and-dendritic-perforated-patch-recordings-reveal-b-adrenergic-receptor-induced-depolarization-in-medial-prefrontal-cortex-pyramidal-neurons
#5
Bartłomiej Szulczyk
The aim of this perforated-patch study was to test the effect of isoproterenol on the membrane potential in mPFC (medial prefrontal cortex) pyramidal neurons. Isoproterenol depolarized the membrane potential recorded from the soma. This effect was absent in the presence of metoprolol, suggesting the involvement of beta1-adrenergic receptors. The adenylate cyclase activator forskolin also depolarized the membrane potential. Moreover, the effect of isoproterenol was abolished by the adenylate cyclase inhibitor SQ 22536...
2016: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/27332740/high-throughput-bioassay-for-beta1-adrenoceptor-autoantibody-detection
#6
Shivanjali Joshi-Barr, Annekathrin Haberland, Sabine Bartel, Johannes Müller, Ted Choi, Gerd Wallukat
BACKGROUND: While the involvement of adrenergic beta1-autoantibodies (beta1-AABs) in pathogenesis of cardiomyopathies is well established as are the benefits associated with autoantibody removal by immunoapheresis, the development of drugs neutralizing beta1-AABs in-vivo has been slowed due to a lack of high throughput autoantibody analytics. Highly scalable routine diagnostics involving immobilized binding partners have mostly failed in comparison to the laborious bioassays, which are difficult to scale up, but present the most reliable and sensitive tools for detecting the beta1-autoantibodies...
September 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27027728/association-between-beta1-adrenergic-receptor-polymorphism-and-risk-of-icd-shock-in-heart-failure-patients
#7
Luisa Zanolla, Paola Guarise, Luca Tomasi, Corrado Vassanelli, Nicola Cicorella, Roberto Zanini, Simonetta Guarrera, Giovanni Fiorito, Giuseppe Matullo
BACKGROUND: Sympathetic activation in heart failure patients favors the development of ventricular arrhythmias, thus leading to an increased risk of sudden cardiac death. β1 - and β2 -adrenergic receptor polymorphisms have been linked to the risk of sudden death. Implantable cardioverter-defibrillators (ICD) are implanted in a large percentage of heart failure patients, and beyond preventing sudden cardiac death they provide a continuous monitoring of major ventricular arrhythmias and of their own interventions...
June 2016: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/27001422/cardiac-salvage-by-tweaking-with-beta-3-adrenergic-receptors
#8
REVIEW
Jean-Luc Balligand
Overstimulation of the orthosympathetic system leads to cardiovascular cell and tissue damage through prolonged activation of β-1-2 adrenergic receptors (BARs). The more recent identification of the third isotype of BAR (B3AR) in cardiac myocytes and endothelial cells with a distinctive coupling and effect on cardiac function and remodelling introduced a new facet to this paradigm. In particular, B3AR is up-regulated in cardiac disease and less prone to homologous desensitization, which may reinforce its influence on the diseased myocardium...
July 15, 2016: Cardiovascular Research
https://www.readbyqxmd.com/read/26922884/co-translational-formation-and-pharmacological-characterization-of-beta1-adrenergic-receptor-nanodisc-complexes-with-different-lipid-environments
#9
Ralf-Bernhardt Rues, Volker Dötsch, Frank Bernhard
G protein-coupled receptors are of key significance for biomedical research. Streamlined approaches for their efficient recombinant production are of pivotal interest in order to explore their intrinsic conformational dynamics and complex ligand binding behavior. We have systematically optimized the co-translational association and folding of G protein-coupled receptors with defined membranes of nanodiscs by cell-free expression approaches. Each optimization step was quantified and the ligand binding active fraction of the receptor samples could drastically be improved...
June 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/26306578/blood-pressure-lowering-efficacy-of-dual-alpha-and-beta-blockers-for-primary-hypertension
#10
REVIEW
Gavin W K Wong, Alexandra Laugerotte, James M Wright
BACKGROUND: Drugs with combined alpha and beta blocking activity are commonly prescribed to treat hypertension. However, the blood pressure (BP) lowering efficacy of this class of beta blockers has not been systematically reviewed and quantified. OBJECTIVES: To quantify the dose-related effects of various types of dual alpha and beta adrenergic receptor blockers (dual receptor blockers) on systolic and diastolic blood pressure versus placebo in patients with primary hypertension...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/25966954/beta1-adrenergic-receptor-mediated-dilation-of-rat-cerebral-artery-requires-shaker-type-kv1-channels-on-psd95-scaffold
#11
Christopher L Moore, Samantha J McClenahan, Hillary M Hanvey, Dae-Song Jang, Piper L Nelson, Biny K Joseph, Sung W Rhee
Postsynaptic density-95 (PSD95) is a scaffolding protein in cerebral vascular smooth muscle cells (cVSMCs), which binds to Shaker-type K(+) (KV1) channels and facilitates channel opening through phosphorylation by protein kinase A. β1-Adrenergic receptors (β1ARs) also have a binding motif for PSD95. Functional association of β1AR with KV1 channels through PSD95 may represent a novel vasodilator complex in cerebral arteries (CA). We explored whether a β1AR-PSD95-KV1 complex is a determinant of rat CA dilation...
September 2015: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/25634756/beta-1-adrenergic-receptors-mediate-nrf2-ho-1-hmgb1-axis-regulation-to-attenuate-hypoxia-reoxygenation-induced-cardiomyocytes-injury-in-vitro
#12
Jichun Wang, Xiaorong Hu, Jing Xie, Weipan Xu, Hong Jiang
UNLABELLED: BACKGROUD/AIMS: The aim of the study was to evaluate the effects of beta1-adrenergic receptors (β1-ARs) -mediated nuclear factor erythroid 2-related factor 2 (Nrf2)-heme oxygenase-1 (HO-1)-high mobility group box 1 protein (HMGB1) axis regulation in hypoxia/reoxygenation (H/R)-induced neonatal rat cardiomyocytes. METHODS: The neonatal cultured cardiomyocytes were concentration-dependently pretreated by dobutamine (DOB), a selective β1-adrenergic receptor agonist, in the absence and/or presence of LY294002 (a phosphatidylinositol 3-kinase (PI3K) inhibitor), SB203580 (a p38mitogen-activated-protein kinase (p38MAPK) inhibitor), Nrf2siRNA and HO-1siRNA, respectively, and then treated by H/R...
2015: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/25503457/protective-effects-of-%C3%AE-1-2-adrenergic-receptor-deletion-in-a-model-of-oxygen-induced-retinopathy
#13
Massimo Dal Monte, Maurizio Cammalleri, Elisabetta Mattei, Luca Filippi, Paola Bagnoli
PURPOSE: β-adrenergic receptors (β-ARs) regulate angiogenesis in proliferative retinopathies. We studied the effects of β1/2-AR deletion in a model of oxygen-induced retinopathy (OIR) to confirm the role of β1- and/or β2-ARs in regulating angiogenesis and to get insights into the role of β3-ARs. METHODS: Mice with β1/2-AR deletion (KO) were used. Levels of norepinephrine (NE), β3-ARs, transcription, and proangiogenic factors were evaluated. Retinas were analyzed for avascular area and neovascular tufts in the superficial plexus...
January 2015: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/25488774/effects-of-stachydrine-on-norepinephrine-induced-neonatal-rat-cardiac-myocytes-hypertrophy-and-intracellular-calcium-transients
#14
Chen Zhang, Xiao-Li Shan, Yue-Ling Liao, Pei Zhao, Wei Guo, Hong-Chang Wei, Rong Lu
BACKGROUND: Leonurus heterophyllus sweet has been suggested to have cardioprotective effects against heart diseases, including ischemic diseases and ventricular remodeling. However, the active ingredients of the herb and the underlying mechanisms are poorly understood. The aim of the present study was to investigate the effects of stachydrine (STA), a major constituent of Leonurus heterophyllus sweet, on norepinephrine (NE) induced hypertrophy and the changes of calcium transients in neonatal rat cardiomyocytes...
2014: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/25300466/juvenile-stress-alters-ltp-in-ventral-hippocampal-slices-involvement-of-noradrenergic-mechanisms
#15
Gayane Grigoryan, Ziv Ardi, Anne Albrecht, Gal Richter-Levin, Menahem Segal
Childhood adversity is a prominent risk factor for developing stress-related disorders in adulthood. It can be modeled in rodents, where altered stress responses in adulthood have been observed. The ventral hippocampus is thought to be involved in emotional responses and displays a unique modulation of synaptic plasticity following exposure to stress. Here, we investigated the long-term effect of juvenile stress (at postnatal age of 27-29 days) on synaptic plasticity in the ventral and dorsal hippocampus of adult, 3 month old rats...
February 1, 2015: Behavioural Brain Research
https://www.readbyqxmd.com/read/25272708/-the-mechanism-of-change-in-speed-of-agglutination-of-human-erythrocytes-under-the-influence-of-adrenaline
#16
A I Volodchenko, V I Tsirkin, A A Kostiaev
In the study of red blood cells of 80 men found that adrenaline (10(-10) - 10(-6) g/mL) and phenylephrine (10-(10) - 10(-6) g/mL) dose-dependently increase the speed of agglutination of red blood cells, according to the decrease in agglutination of the start time and ginipral (10(-10) - 10(-7) g/mL), on the contrary, decreases it. The effect of adrenaline and phenylephrine is blocked by nicergoline (10(-6) g/mL), increased obzidan (10(-6) g/mL) and does not change under the action ofyohimbine (10(-6) g/mL) and atenolol (10(-6) g/mL)...
March 2014: Fiziologiia Cheloveka
https://www.readbyqxmd.com/read/25191229/noradrenalin-and-dopamine-receptors-both-control-camp-pka-signaling-throughout-the-cerebral-cortex
#17
Shinobu Nomura, Maud Bouhadana, Carole Morel, Philippe Faure, Bruno Cauli, Bertrand Lambolez, Régine Hepp
Noradrenergic fibers innervate the entire cerebral cortex, whereas the cortical distribution of dopaminergic fibers is more restricted. However, the relative functional impact of noradrenalin and dopamine receptors in various cortical regions is largely unknown. Using a specific genetic label, we first confirmed that noradrenergic fibers innervate the entire cortex whereas dopaminergic fibers were present in all layers of restricted medial and lateral areas but only in deep layers of other areas. Imaging of a genetically encoded sensor revealed that noradrenalin and dopamine widely activate PKA in cortical pyramidal neurons of frontal, parietal and occipital regions with scarce dopaminergic fibers...
2014: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/25020679/272pre-reperfusion-metoprolol-administration-reduces-ischemia-reperfusion-injury-iri-through-beta1-adrenergic-receptor-b1ar-blockade-in-the-circulating-cells
#18
J Garcia-Prieto, R Fernandez-Jimenez, V Sreeramkumar, I G Lunar, D Sanz-Rosa, V Zorita, G Pizarro, A Hidalgo, V Fuster, B Ibanez
BACKGROUND: We have shown that pre-reperfusion metoprolol reduces infarct size in humans (METOCARD-CNIC trial). Preclinical data suggest that this strategy reduces myocardial neutrophil infiltration. Here we evaluated the potential involvement of circulating cells in the cardioprotection afforded by metoprolol. METHODS: WT and b1AR-KO mice were subjected to myocardial IRI (45min/24h Ischemia/Reperfusion). Ten minutes before reperfusion, animals were randomized to receive either i...
July 15, 2014: Cardiovascular Research
https://www.readbyqxmd.com/read/24861502/-cardiovascular-effects-of-beta1-and-beta3-adrenergic-receptor-autoantibodies-in-lewis-rat
#19
E Montaudon, M A Abdelkrim, J-C Desfontis, M Y Mallem
PURPOSE: To analyze vascular reactivity changes in response to immunization protocols with antigens corresponding to the second extracellular loop of -β3 and -β1 and 3 adrenergic receptors (AR). METHODS: Lewis rats were immunized for 3months with peptidic sequences corresponding to the second extracellular loop of β3-AR or β1 and 3-AR. Specific β3-AR antibodies were characterized by Elisa and purified using "Proteus Protein G" kit. Their functionality were tested in rabbit isolated ventricular cardiomyocytes...
June 2014: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/24844469/the-stimulatory-effects-of-alpha1-adrenergic-receptors-on-tgf-beta1-igf-1-and-hyaluronan-production-in-human-skin-fibroblasts
#20
Ming-Huei Liao, Shyh-Shyan Liu, I-Chin Peng, Feng-Jen Tsai, Han Hsiang Huang
Skin fibroblasts modulate tissue repair, wound healing and immunological responses. Adrenergic receptors (ARs) mediate important physiological functions, such as endocrine, metabolic and neuronal activity. In this study, the expression α1A-ARs in human skin fibroblasts is examined and verified. Regulatory effects of α1-agonist cirazoline on cell migration and the production of transforming growth factor β1 (TGF-β1), insulin-like growth factor 1 (IGF-1), hyaluronan (HA), fibronectin and procollagen type I carboxy-terminal peptide (PIP) by human skin fibroblasts are assessed and validated...
September 2014: Cell and Tissue Research
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