keyword
MENU ▼
Read by QxMD icon Read
search

Beta1 adrenergic receptor

keyword
https://www.readbyqxmd.com/read/28480811/changes-in-brain-activation-during-sedation-induced-by-dexmedetomidine
#1
Won-Ho Kim, Dongrae Cho, Boreom Lee, Jae-Jin Song, Teo Jeon Shin
Objective Dexmedetomidine (DEX) has been widely used as a sedative, acting as an α2-adrenergic agonist on autoreceptors, presynaptic receptors and postsynaptic receptors without risk of respiratory depression. Although consciousness impairment is closely related to disturbances of brain function in different frequency bands, the time-varying DEX effects on cortical activity in specific frequency bands has not yet been studied. Methods We used electroencephalography (EEG) to analyse differences in cerebral cortex activity between the awake and sedated states, using electromagnetic tomography (standardized low resolution electromagnetic tomography (sLORETA)) to localize multiple channel scalp recordings of cerebral electric activity to specific brain regions...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28446880/shifts-in-the-gut-microbiota-composition-due-to-depleted-bone-marrow-beta-adrenergic-signaling-are-associated-with-suppressed-inflammatory-transcriptional-networks-in-the-mouse-colon
#2
Tao Yang, Niousha Ahmari, Jordan T Schmidt, Ty Redler, Rebeca Arocha, Kevin Pacholec, Kacy L Magee, Wendi Malphurs, Jennifer L Owen, Gregory A Krane, Eric Li, Gary P Wang, Thomas W Vickroy, Mohan K Raizada, Christopher J Martyniuk, Jasenka Zubcevic
The brain-gut axis plays a critical role in the regulation of different diseases, many of which are characterized by sympathetic dysregulation. However, a direct link between sympathetic dysregulation and gut dysbiosis remains to be illustrated. Bone marrow (BM)-derived immune cells continuously interact with the gut microbiota to maintain homeostasis in the host. Their function is largely dependent upon the sympathetic nervous system acting via adrenergic receptors present on the BM immune cells. In this study, we utilized a novel chimera mouse that lacks the expression of BM beta1/2 adrenergic receptors (b1/2-ARs) to investigate the role of the sympathetic drive to the BM in gut and microbiota homeostasis...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28231305/effects-of-vasoactive-drugs-on-crystalloid-fluid-kinetics-in-septic-sheep
#3
Yuhong Li, Zheng Xiaozhu, Ru Guomei, Ding Qiannan, Robert G Hahn
PURPOSE: Crystalloid fluid and vasoactive drugs are used in the early treatment of sepsis. The purpose of the present study was to examine how these drugs alter plasma volume expansion, peripheral edema, and urinary excretion. METHODS: Twenty-five anesthetized sheep were made septic by cecal puncture and a short infusion of lipopolysaccharide. After 50 min, a slow infusion of isotonic saline was initiated: the saline either contained no drug, norepinephrine (1 μg/kg/min), phenylephrine (3 μg/kg/min), dopamine (50 μg/kg/min), or esmolol (50 μg/kg/min)...
2017: PloS One
https://www.readbyqxmd.com/read/28167537/site-specific-o-glycosylation-by-polypeptide-n-acetylgalactosaminyltransferase-2-galnac-transferase-t2-co-regulates-%C3%AE-1-adrenergic-receptor-n-terminal-cleavage
#4
Christoffer K Goth, Hanna E Tuhkanen, Hamayun Khan, Jarkko J Lackman, Shengjun Wang, Yoshiki Narimatsu, Lasse H Hansen, Christopher M Overall, Henrik Clausen, Katrine T Schjoldager, Ulla E Petäjä-Repo
The β1-adrenergic receptor (β1AR) is a G protein-coupled receptor (GPCR) and the predominant adrenergic receptor subtype in the heart, where it mediates cardiac contractility and the force of contraction. Although it is the most important target for β-adrenergic antagonists, such as β-blockers, relatively little is yet known about its regulation. We have shown previously that β1AR undergoes constitutive and regulated N-terminal cleavage participating in receptor down-regulation and, moreover, that the receptor is modified by O-glycosylation...
March 17, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28163240/cardiomyopathy-an-approach-to-the-autoimmune-background
#5
REVIEW
Niels-Peter Becker, Johannes Müller, Peter Göttel, Gerd Wallukat, Ingolf Schimke
Autoimmunity is increasingly accepted as the origin or amplifier of various diseases. In contrast to classic autoantibodies (AABs), which induce immune responses resulting in the destruction of the affected tissue, an additional class of AABs is directed against G-protein-coupled receptors (GPCRs; GPCR-AABs). GPCR-AABs functionally affect their related GPCRs for activation of receptor mediated signal cascades. Diseases which are characterized by the presence of GPCR-AABs with evidence for disease-specific pathogenic activity could be named "functional autoantibody disease"...
March 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/27993566/beta2-adrenergic-receptor-homodimers-role-of-transmembrane-domain-1-and-helix-8-in-dimerization-and-cell-surface-expression
#6
Vikas K Parmar, Ellinor Grinde, Joseph E Mazurkiewicz, Katharine Herrick-Davis
Even though there are hundreds of reports in the published literature supporting the hypothesis that G protein-coupled receptors (GPCR) form and function as dimers this remains a highly controversial area of research and mechanisms governing homodimer formation are poorly understood. Crystal structures revealing homodimers have been reported for many different GPCR. For adrenergic receptors, a potential dimer interface involving transmembrane domain 1 (TMD1) and helix 8 (H8) was identified in crystal structures of the beta1-adrenergic (β1-AR) and β2-AR...
December 18, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27754210/os-31-02-antihypertensive-response-to-bisoprolol-was-not-related-to-polymorphisms-in-adrb1-or-cyp2d6-in-chinese-hypertensive-patients
#7
Weiwei Zeng, Tanya Chu, Miao Hu, Alice Kong, Brian Tomlinson
OBJECTIVE: The blood pressure (BP) response to antihypertensive drugs varies considerably between different patients. The response to some beta-blockers has been associated with polymorphisms in the beta1-adrenergic receptor (ADRB1) or cytochrome P450 2D6 (CYP2D6) genes. We examined the effects of common polymorphisms in ADRB1 and CYP2D6 on the response to bisoprolol in 100 Chinese patients. DESIGN AND METHOD: Chinese patients with primary hypertension with sitting clinic systolic BP (SBP) 140-169 mmHg and/or diastolic BP (DBP) 90-109 mmHg after placebo run-in were treated with open-label bisoprolol 2...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27643167/os-31-02-antihypertensive-response-to-bisoprolol-was-not-related-to-polymorphisms-in-adrb1-or-cyp2d6-in-chinese-hypertensive-patients
#8
Weiwei Zeng, Tanya Chu, Miao Hu, Alice Kong, Brian Tomlinson
OBJECTIVE: The blood pressure (BP) response to antihypertensive drugs varies considerably between different patients. The response to some beta-blockers has been associated with polymorphisms in the beta1-adrenergic receptor (ADRB1) or cytochrome P450 2D6 (CYP2D6) genes. We examined the effects of common polymorphisms in ADRB1 and CYP2D6 on the response to bisoprolol in 100 Chinese patients. DESIGN AND METHOD: Chinese patients with primary hypertension with sitting clinic systolic BP (SBP) 140-169 mmHg and/or diastolic BP (DBP) 90-109 mmHg after placebo run-in were treated with open-label bisoprolol 2...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27437032/visceral-adiposity-syndrome
#9
REVIEW
Heno F Lopes, Maria Lúcia Corrêa-Giannella, Fernanda M Consolim-Colombo, Brent M Egan
The association of anthropometric (waist circumference) and hemodynamic (blood pressure) changes with abnormalities in glucose and lipid metabolism has been motivation for a lot of discussions in the last 30 years. Nowadays, blood pressure, body mass index/abdominal circumference, glycemia, triglyceridemia, and HDL-cholesterol concentrations are considered in the definition of Metabolic syndrome, referred as Visceral adiposity syndrome (VAS) in the present review. However, more than 250 years ago an association between visceral and mediastinal obesity with hypertension, gout, and obstructive apnea had already been recognized...
2016: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/27416924/sympathectomy-reduces-tumor-weight-and-affects-expression-of-tumor-related-genes-in-melanoma-tissue-in-the-mouse
#10
Lubica Horvathova, Alexandra Padova, Andrej Tillinger, Jana Osacka, Jozef Bizik, Boris Mravec
Accumulated evidence indicates that sympathetic nerves may potentiate tumor growth, including melanoma. To elucidate possible mechanisms for this effect, we performed chemical sympathectomy by intraperitoneal (i.p.) injection of the neurotoxin 6-hydroxydopamine hydrobromide (100 mg/kg of body weight); in nine adult male C57BL/6J mice; nine control mice received i.p. vehicle (VEH). Seven days later, all mice were injected subcutaneously with 3 × 10(3) B16-F10 melanoma cells. Mice were euthanized 20 d after injection of melanoma cells, for measurement of tumor weight and expression of genes related to sympathetic signaling, apoptosis, hypoxia and angiogenesis in tumor tissue...
September 2016: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/27373953/somatic-and-dendritic-perforated-patch-recordings-reveal-b-adrenergic-receptor-induced-depolarization-in-medial-prefrontal-cortex-pyramidal-neurons
#11
Bartłomiej Szulczyk
The aim of this perforated-patch study was to test the effect of isoproterenol on the membrane potential in mPFC (medial prefrontal cortex) pyramidal neurons. Isoproterenol depolarized the membrane potential recorded from the soma. This effect was absent in the presence of metoprolol, suggesting the involvement of beta1-adrenergic receptors. The adenylate cyclase activator forskolin also depolarized the membrane potential. Moreover, the effect of isoproterenol was abolished by the adenylate cyclase inhibitor SQ 22536...
2016: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/27332740/high-throughput-bioassay-for-beta1-adrenoceptor-autoantibody-detection
#12
Shivanjali Joshi-Barr, Annekathrin Haberland, Sabine Bartel, Johannes Müller, Ted Choi, Gerd Wallukat
BACKGROUND: While the involvement of adrenergic beta1-autoantibodies (beta1-AABs) in pathogenesis of cardiomyopathies is well established as are the benefits associated with autoantibody removal by immunoapheresis, the development of drugs neutralizing beta1-AABs in-vivo has been slowed due to a lack of high throughput autoantibody analytics. Highly scalable routine diagnostics involving immobilized binding partners have mostly failed in comparison to the laborious bioassays, which are difficult to scale up, but present the most reliable and sensitive tools for detecting the beta1-autoantibodies...
September 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27027728/association-between-beta1-adrenergic-receptor-polymorphism-and-risk-of-icd-shock-in-heart-failure-patients
#13
Luisa Zanolla, Paola Guarise, Luca Tomasi, Corrado Vassanelli, Nicola Cicorella, Roberto Zanini, Simonetta Guarrera, Giovanni Fiorito, Giuseppe Matullo
BACKGROUND: Sympathetic activation in heart failure patients favors the development of ventricular arrhythmias, thus leading to an increased risk of sudden cardiac death. β1 - and β2 -adrenergic receptor polymorphisms have been linked to the risk of sudden death. Implantable cardioverter-defibrillators (ICD) are implanted in a large percentage of heart failure patients, and beyond preventing sudden cardiac death they provide a continuous monitoring of major ventricular arrhythmias and of their own interventions...
June 2016: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/27001422/cardiac-salvage-by-tweaking-with-beta-3-adrenergic-receptors
#14
REVIEW
Jean-Luc Balligand
Overstimulation of the orthosympathetic system leads to cardiovascular cell and tissue damage through prolonged activation of β-1-2 adrenergic receptors (BARs). The more recent identification of the third isotype of BAR (B3AR) in cardiac myocytes and endothelial cells with a distinctive coupling and effect on cardiac function and remodelling introduced a new facet to this paradigm. In particular, B3AR is up-regulated in cardiac disease and less prone to homologous desensitization, which may reinforce its influence on the diseased myocardium...
July 15, 2016: Cardiovascular Research
https://www.readbyqxmd.com/read/26922884/co-translational-formation-and-pharmacological-characterization-of-beta1-adrenergic-receptor-nanodisc-complexes-with-different-lipid-environments
#15
Ralf-Bernhardt Rues, Volker Dötsch, Frank Bernhard
G protein-coupled receptors are of key significance for biomedical research. Streamlined approaches for their efficient recombinant production are of pivotal interest in order to explore their intrinsic conformational dynamics and complex ligand binding behavior. We have systematically optimized the co-translational association and folding of G protein-coupled receptors with defined membranes of nanodiscs by cell-free expression approaches. Each optimization step was quantified and the ligand binding active fraction of the receptor samples could drastically be improved...
June 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/26306578/blood-pressure-lowering-efficacy-of-dual-alpha-and-beta-blockers-for-primary-hypertension
#16
REVIEW
Gavin W K Wong, Alexandra Laugerotte, James M Wright
BACKGROUND: Drugs with combined alpha and beta blocking activity are commonly prescribed to treat hypertension. However, the blood pressure (BP) lowering efficacy of this class of beta blockers has not been systematically reviewed and quantified. OBJECTIVES: To quantify the dose-related effects of various types of dual alpha and beta adrenergic receptor blockers (dual receptor blockers) on systolic and diastolic blood pressure versus placebo in patients with primary hypertension...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/25966954/beta1-adrenergic-receptor-mediated-dilation-of-rat-cerebral-artery-requires-shaker-type-kv1-channels-on-psd95-scaffold
#17
Christopher L Moore, Samantha J McClenahan, Hillary M Hanvey, Dae-Song Jang, Piper L Nelson, Biny K Joseph, Sung W Rhee
Postsynaptic density-95 (PSD95) is a scaffolding protein in cerebral vascular smooth muscle cells (cVSMCs), which binds to Shaker-type K(+) (KV1) channels and facilitates channel opening through phosphorylation by protein kinase A. β1-Adrenergic receptors (β1ARs) also have a binding motif for PSD95. Functional association of β1AR with KV1 channels through PSD95 may represent a novel vasodilator complex in cerebral arteries (CA). We explored whether a β1AR-PSD95-KV1 complex is a determinant of rat CA dilation...
September 2015: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/25634756/beta-1-adrenergic-receptors-mediate-nrf2-ho-1-hmgb1-axis-regulation-to-attenuate-hypoxia-reoxygenation-induced-cardiomyocytes-injury-in-vitro
#18
Jichun Wang, Xiaorong Hu, Jing Xie, Weipan Xu, Hong Jiang
UNLABELLED: BACKGROUD/AIMS: The aim of the study was to evaluate the effects of beta1-adrenergic receptors (β1-ARs) -mediated nuclear factor erythroid 2-related factor 2 (Nrf2)-heme oxygenase-1 (HO-1)-high mobility group box 1 protein (HMGB1) axis regulation in hypoxia/reoxygenation (H/R)-induced neonatal rat cardiomyocytes. METHODS: The neonatal cultured cardiomyocytes were concentration-dependently pretreated by dobutamine (DOB), a selective β1-adrenergic receptor agonist, in the absence and/or presence of LY294002 (a phosphatidylinositol 3-kinase (PI3K) inhibitor), SB203580 (a p38mitogen-activated-protein kinase (p38MAPK) inhibitor), Nrf2siRNA and HO-1siRNA, respectively, and then treated by H/R...
2015: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/25503457/protective-effects-of-%C3%AE-1-2-adrenergic-receptor-deletion-in-a-model-of-oxygen-induced-retinopathy
#19
Massimo Dal Monte, Maurizio Cammalleri, Elisabetta Mattei, Luca Filippi, Paola Bagnoli
PURPOSE: β-adrenergic receptors (β-ARs) regulate angiogenesis in proliferative retinopathies. We studied the effects of β1/2-AR deletion in a model of oxygen-induced retinopathy (OIR) to confirm the role of β1- and/or β2-ARs in regulating angiogenesis and to get insights into the role of β3-ARs. METHODS: Mice with β1/2-AR deletion (KO) were used. Levels of norepinephrine (NE), β3-ARs, transcription, and proangiogenic factors were evaluated. Retinas were analyzed for avascular area and neovascular tufts in the superficial plexus...
January 2015: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/25488774/effects-of-stachydrine-on-norepinephrine-induced-neonatal-rat-cardiac-myocytes-hypertrophy-and-intracellular-calcium-transients
#20
Chen Zhang, Xiao-Li Shan, Yue-Ling Liao, Pei Zhao, Wei Guo, Hong-Chang Wei, Rong Lu
BACKGROUND: Leonurus heterophyllus sweet has been suggested to have cardioprotective effects against heart diseases, including ischemic diseases and ventricular remodeling. However, the active ingredients of the herb and the underlying mechanisms are poorly understood. The aim of the present study was to investigate the effects of stachydrine (STA), a major constituent of Leonurus heterophyllus sweet, on norepinephrine (NE) induced hypertrophy and the changes of calcium transients in neonatal rat cardiomyocytes...
2014: BMC Complementary and Alternative Medicine
keyword
keyword
31916
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"