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Beta1 adrenergic receptor

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https://www.readbyqxmd.com/read/29523072/neuroprotective-dobutamine-treatment-upregulates-superoxide-dismutase-3-anti-oxidant-and-survival-genes-and-attenuates-genes-mediating-inflammation
#1
Tina Markus, David Ley, Stefan R Hansson, Tadeusz Wieloch, Karsten Ruscher
BACKGROUND: Labor subjects the fetus to an hypoxic episode and concomitant adrenomodullary catecholamine surge that may provide protection against the hypoxic insult. The beta1-adrenergic agonist dobutamine protects against hypoxia/aglycemia induced neuronal damage. We aimed to identify the associated protective biological processes involved. RESULTS: Hippocampal slices from 6 days old mice showed significant changes of gene expression comparing slices with or without dobutamine (50 mM) in the following two experimental paradigms: (1) control conditions versus lipopolysacharide (LPS) stimulation and (2) oxygen-glucose deprivation (OGD), versus combined LPS/OGD...
March 9, 2018: BMC Neuroscience
https://www.readbyqxmd.com/read/29394143/left-ventricle-function-during-therapeutic-hypothermia-with-beta1-adrenergic-receptor-blockade
#2
Harald A Bergan, Per S Halvorsen, Andreas Espinoza, Viesturs Kerans, Helge Skulstad, Erik Fosse, Jan F Bugge
Therapeutic hypothermia is an established treatment in patients resuscitated from cardiac arrest. It is usually well-tolerated circulatory, but hypothermia negatively effects myocardial contraction and relaxation velocities and increases diastolic filling restrictions. A significant proportion of resuscitated patients are treated with long-acting beta-receptor blocking agents' prearrest, but the combined effects of hypothermia and beta-blockade on left ventricle (LV) function are not previously investigated...
February 2, 2018: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/29230810/trauma-exposure-interacts-with-the-genetic-risk-of-bipolar-disorder-in-alcohol-misuse-of-us-soldiers
#3
R Polimanti, J Kaufman, H Zhao, H R Kranzler, R J Ursano, R C Kessler, M B Stein, J Gelernter
OBJECTIVE: To investigate whether trauma exposure moderates the genetic correlation between substance use disorders and psychiatric disorders, we tested whether trauma exposure modifies the association of genetic risks for mental disorders with alcohol misuse and nicotine dependence (ND) symptoms. METHODS: High-resolution polygenic risk scores (PRSs) were calculated for 10 732 US Army soldiers (8346 trauma-exposed and 2386 trauma-unexposed) based on genome-wide association studies of bipolar disorder (BD), major depressive disorder, and schizophrenia...
February 2018: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29193283/diastolic-dysfunction-in-pulmonary-artery-hypertension-creatine-kinase-and-the-potential-therapeutic-benefit-of-beta-blockers
#4
Ewan D Fowler, Mark J Drinkhill, Rachel Stones, Ed White
Passive properties of the myocardium influence diastolic filling and cardiac output. In heart failure, changes in contributors to the passive properties of the ventricle, such as titin and collagen, and loss of the metabolic enzyme creatine kinase, increase resistance to filling resulting in diastolic dysfunction. Pulmonary artery hypertension (PAH) arises from interactions between the pulmonary vasculature and the right ventricle (RV) which ultimately leads to RV failure. Beta1-adrenergic receptor blockers (BB) act on the myocardium and are beneficial in left heart failure but are not used in PAH...
November 28, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29106524/cardiac-myocyte-%C3%AE-3-adrenergic-receptors-prevent-myocardial-fibrosis-by-modulating-oxidant-stress-dependent-paracrine-signaling
#5
Nerea Hermida, Lauriane Michel, Hrag Esfahani, Emilie Dubois-Deruy, Joanna Hammond, Caroline Bouzin, Andreas Markl, Henri Colin, Anne Van Steenbergen, Christophe De Meester, Christophe Beauloye, Sandrine Horman, Xiaoke Yin, Manuel Mayr, Jean-Luc Balligand
Aims: Human and mouse cardiac beta3-adrenergic receptors (beta3AR) exert antipathetic effects to those of beta1-2AR stimulation. We examined their role in modulating myocardial remodelling, particularly fibrosis in response to haemodynamic stress. Methods and results: Mice with cardiac myocyte-specific expression of beta3AR (ADRB3-tg) or tamoxifen-inducible homozygous deletion (c-Adrb3-ko, with loxP-targeted Adrb3) were submitted to transaortic constriction. A superfusion assay was used for proteomic analysis of paracrine mediators between beta3AR-expressing cardiac myocytes and cardiac fibroblasts cultured separately...
July 6, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28795160/performance-and-in-house-validation-of-a-bioassay-for-the-determination-of-beta1-autoantibodies-found-in-patients-with-cardiomyopathy
#6
Katrin Wenzel, Sarah Schulze-Rothe, Annekathrin Haberland, Johannes Müller, Gerd Wallukat, Hanna Davideit
BACKGROUND: Autoantibodies specific for the adrenergic beta1-receptor were identified to be an essential factor for the pathogenesis of dilated cardiomyopathy. For the detection of these autoantibodies, a bioassay was developed and has been used, measuring the positive chronotropic effect on spontaneously beating neonatal rat cardiomyocytes. In order to use this bioassay as an analytical tool to monitor the effectiveness of autoantibody neutralizing therapy in a regulated field, there is a need to assess its analytical performance and validate it according to current guidelines...
July 2017: Heliyon
https://www.readbyqxmd.com/read/28674870/heart-rate-response-to-alpha-2-adrenergic-receptor-antagonism-by-antipsychotics
#7
David D Kim, Donna J Lang, Darren E R Warburton, Melissa L Woodward, Randall F White, Alasdair M Barr, William G Honer, Ric M Procyshyn
PURPOSE: To explore the relationship between antipsychotic-associated antagonism of alpha2 -adrenergic receptors and resting heart rate in individuals with schizophrenia. METHODS: Thirty-one inpatients treated with antipsychotics were included in this exploratory analysis. Antipsychotic doses were converted to haloperidol equivalents for alpha2 -adrenergic receptor antagonism. Resting heart rate was measured with the patient in the seated upright posture. RESULTS: After controlling for confounding variables, the relationship between alpha2 -adrenergic receptor antagonism and resting heart rate demonstrated a positive linear effect (P = 0...
December 2017: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/28590038/effects-of-oestrogen-and-cimicifuga-racemosa-on-the-cardiac-noradrenaline-pathway-of-ovariectomized-rats
#8
Yao Liu, Jing Zhang, Shuya Liu, Wenjuan Wang, Xing Chen, Hai Jiang, Junlei Li, Ke Wang, Wenpei Bai, Haicheng Zhang, Lihua Qin
What is the central question of this study? We investigated the effects of oestrogen and Cimicifuga racemosa on the stellate ganglion, cardiac noradrenaline pathway and Ca(2+) -calmodulin-dependent protein kinase II in ovariectomized rats. What is the main finding and its importance? The right stellate ganglion, but not the left, may be associated with decreased left ventricular noradrenaline content in ovariectomized rats. Oestrogen can reverse all changes caused by ovariectomy. Cimicifuga racemosa did not affect left ventricular noradrenaline, but decreased protein expression of β1 -adrenergic receptor and Ca(2+) -calmodulin-dependent protein kinase II...
June 7, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28480811/changes-in-brain-activation-during-sedation-induced-by-dexmedetomidine
#9
Won-Ho Kim, Dongrae Cho, Boreom Lee, Jae-Jin Song, Teo Jeon Shin
Objective Dexmedetomidine (DEX) has been widely used as a sedative, acting as an α2-adrenergic agonist on autoreceptors, presynaptic receptors and postsynaptic receptors without risk of respiratory depression. Although consciousness impairment is closely related to disturbances of brain function in different frequency bands, the time-varying DEX effects on cortical activity in specific frequency bands has not yet been studied. Methods We used electroencephalography (EEG) to analyse differences in cerebral cortex activity between the awake and sedated states, using electromagnetic tomography (standardized low resolution electromagnetic tomography (sLORETA)) to localize multiple channel scalp recordings of cerebral electric activity to specific brain regions...
June 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28446880/shifts-in-the-gut-microbiota-composition-due-to-depleted-bone-marrow-beta-adrenergic-signaling-are-associated-with-suppressed-inflammatory-transcriptional-networks-in-the-mouse-colon
#10
Tao Yang, Niousha Ahmari, Jordan T Schmidt, Ty Redler, Rebeca Arocha, Kevin Pacholec, Kacy L Magee, Wendi Malphurs, Jennifer L Owen, Gregory A Krane, Eric Li, Gary P Wang, Thomas W Vickroy, Mohan K Raizada, Christopher J Martyniuk, Jasenka Zubcevic
The brain-gut axis plays a critical role in the regulation of different diseases, many of which are characterized by sympathetic dysregulation. However, a direct link between sympathetic dysregulation and gut dysbiosis remains to be illustrated. Bone marrow (BM)-derived immune cells continuously interact with the gut microbiota to maintain homeostasis in the host. Their function is largely dependent upon the sympathetic nervous system acting via adrenergic receptors present on the BM immune cells. In this study, we utilized a novel chimera mouse that lacks the expression of BM beta1/2 adrenergic receptors (b1/2-ARs) to investigate the role of the sympathetic drive to the BM in gut and microbiota homeostasis...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28231305/effects-of-vasoactive-drugs-on-crystalloid-fluid-kinetics-in-septic-sheep
#11
Yuhong Li, Zheng Xiaozhu, Ru Guomei, Ding Qiannan, Robert G Hahn
PURPOSE: Crystalloid fluid and vasoactive drugs are used in the early treatment of sepsis. The purpose of the present study was to examine how these drugs alter plasma volume expansion, peripheral edema, and urinary excretion. METHODS: Twenty-five anesthetized sheep were made septic by cecal puncture and a short infusion of lipopolysaccharide. After 50 min, a slow infusion of isotonic saline was initiated: the saline either contained no drug, norepinephrine (1 μg/kg/min), phenylephrine (3 μg/kg/min), dopamine (50 μg/kg/min), or esmolol (50 μg/kg/min)...
2017: PloS One
https://www.readbyqxmd.com/read/28167537/site-specific-o-glycosylation-by-polypeptide-n-acetylgalactosaminyltransferase-2-galnac-transferase-t2-co-regulates-%C3%AE-1-adrenergic-receptor-n-terminal-cleavage
#12
Christoffer K Goth, Hanna E Tuhkanen, Hamayun Khan, Jarkko J Lackman, Shengjun Wang, Yoshiki Narimatsu, Lasse H Hansen, Christopher M Overall, Henrik Clausen, Katrine T Schjoldager, Ulla E Petäjä-Repo
The β1 -adrenergic receptor (β1 AR) is a G protein-coupled receptor (GPCR) and the predominant adrenergic receptor subtype in the heart, where it mediates cardiac contractility and the force of contraction. Although it is the most important target for β-adrenergic antagonists, such as β-blockers, relatively little is yet known about its regulation. We have shown previously that β1 AR undergoes constitutive and regulated N-terminal cleavage participating in receptor down-regulation and, moreover, that the receptor is modified by O -glycosylation...
March 17, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28163240/cardiomyopathy-an-approach-to-the-autoimmune-background
#13
REVIEW
Niels-Peter Becker, Johannes Müller, Peter Göttel, Gerd Wallukat, Ingolf Schimke
Autoimmunity is increasingly accepted as the origin or amplifier of various diseases. In contrast to classic autoantibodies (AABs), which induce immune responses resulting in the destruction of the affected tissue, an additional class of AABs is directed against G-protein-coupled receptors (GPCRs; GPCR-AABs). GPCR-AABs functionally affect their related GPCRs for activation of receptor mediated signal cascades. Diseases which are characterized by the presence of GPCR-AABs with evidence for disease-specific pathogenic activity could be named "functional autoantibody disease"...
March 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/27993566/beta2-adrenergic-receptor-homodimers-role-of-transmembrane-domain-1-and-helix-8-in-dimerization-and-cell-surface-expression
#14
Vikas K Parmar, Ellinor Grinde, Joseph E Mazurkiewicz, Katharine Herrick-Davis
Even though there are hundreds of reports in the published literature supporting the hypothesis that G protein-coupled receptors (GPCR) form and function as dimers this remains a highly controversial area of research and mechanisms governing homodimer formation are poorly understood. Crystal structures revealing homodimers have been reported for many different GPCR. For adrenergic receptors, a potential dimer interface involving transmembrane domain 1 (TMD1) and helix 8 (H8) was identified in crystal structures of the beta1-adrenergic (β1-AR) and β2-AR...
September 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27754210/os-31-02-antihypertensive-response-to-bisoprolol-was-not-related-to-polymorphisms-in-adrb1-or-cyp2d6-in-chinese-hypertensive-patients
#15
Weiwei Zeng, Tanya Chu, Miao Hu, Alice Kong, Brian Tomlinson
OBJECTIVE: The blood pressure (BP) response to antihypertensive drugs varies considerably between different patients. The response to some beta-blockers has been associated with polymorphisms in the beta1-adrenergic receptor (ADRB1) or cytochrome P450 2D6 (CYP2D6) genes. We examined the effects of common polymorphisms in ADRB1 and CYP2D6 on the response to bisoprolol in 100 Chinese patients. DESIGN AND METHOD: Chinese patients with primary hypertension with sitting clinic systolic BP (SBP) 140-169 mmHg and/or diastolic BP (DBP) 90-109 mmHg after placebo run-in were treated with open-label bisoprolol 2...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27643167/os-31-02-antihypertensive-response-to-bisoprolol-was-not-related-to-polymorphisms-in-adrb1-or-cyp2d6-in-chinese-hypertensive-patients
#16
Weiwei Zeng, Tanya Chu, Miao Hu, Alice Kong, Brian Tomlinson
OBJECTIVE: The blood pressure (BP) response to antihypertensive drugs varies considerably between different patients. The response to some beta-blockers has been associated with polymorphisms in the beta1-adrenergic receptor (ADRB1) or cytochrome P450 2D6 (CYP2D6) genes. We examined the effects of common polymorphisms in ADRB1 and CYP2D6 on the response to bisoprolol in 100 Chinese patients. DESIGN AND METHOD: Chinese patients with primary hypertension with sitting clinic systolic BP (SBP) 140-169 mmHg and/or diastolic BP (DBP) 90-109 mmHg after placebo run-in were treated with open-label bisoprolol 2...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27437032/visceral-adiposity-syndrome
#17
REVIEW
Heno F Lopes, Maria Lúcia Corrêa-Giannella, Fernanda M Consolim-Colombo, Brent M Egan
The association of anthropometric (waist circumference) and hemodynamic (blood pressure) changes with abnormalities in glucose and lipid metabolism has been motivation for a lot of discussions in the last 30 years. Nowadays, blood pressure, body mass index/abdominal circumference, glycemia, triglyceridemia, and HDL-cholesterol concentrations are considered in the definition of Metabolic syndrome, referred as Visceral adiposity syndrome (VAS) in the present review. However, more than 250 years ago an association between visceral and mediastinal obesity with hypertension, gout, and obstructive apnea had already been recognized...
2016: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/27416924/sympathectomy-reduces-tumor-weight-and-affects-expression-of-tumor-related-genes-in-melanoma-tissue-in-the-mouse
#18
Lubica Horvathova, Alexandra Padova, Andrej Tillinger, Jana Osacka, Jozef Bizik, Boris Mravec
Accumulated evidence indicates that sympathetic nerves may potentiate tumor growth, including melanoma. To elucidate possible mechanisms for this effect, we performed chemical sympathectomy by intraperitoneal (i.p.) injection of the neurotoxin 6-hydroxydopamine hydrobromide (100 mg/kg of body weight); in nine adult male C57BL/6J mice; nine control mice received i.p. vehicle (VEH). Seven days later, all mice were injected subcutaneously with 3 × 10(3) B16-F10 melanoma cells. Mice were euthanized 20 d after injection of melanoma cells, for measurement of tumor weight and expression of genes related to sympathetic signaling, apoptosis, hypoxia and angiogenesis in tumor tissue...
September 2016: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/27373953/somatic-and-dendritic-perforated-patch-recordings-reveal-b-adrenergic-receptor-induced-depolarization-in-medial-prefrontal-cortex-pyramidal-neurons
#19
Bartłomiej Szulczyk
The aim of this perforated-patch study was to test the effect of isoproterenol on the membrane potential in mPFC (medial prefrontal cortex) pyramidal neurons. Isoproterenol depolarized the membrane potential recorded from the soma. This effect was absent in the presence of metoprolol, suggesting the involvement of beta1-adrenergic receptors. The adenylate cyclase activator forskolin also depolarized the membrane potential. Moreover, the effect of isoproterenol was abolished by the adenylate cyclase inhibitor SQ 22536...
2016: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/27332740/high-throughput-bioassay-for-beta1-adrenoceptor-autoantibody-detection
#20
Shivanjali Joshi-Barr, Annekathrin Haberland, Sabine Bartel, Johannes Müller, Ted Choi, Gerd Wallukat
BACKGROUND: While the involvement of adrenergic beta1-autoantibodies (beta1-AABs) in pathogenesis of cardiomyopathies is well established as are the benefits associated with autoantibody removal by immunoapheresis, the development of drugs neutralizing beta1-AABs in-vivo has been slowed due to a lack of high throughput autoantibody analytics. Highly scalable routine diagnostics involving immobilized binding partners have mostly failed in comparison to the laborious bioassays, which are difficult to scale up, but present the most reliable and sensitive tools for detecting the beta1-autoantibodies...
September 15, 2016: International Journal of Cardiology
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