keyword
MENU ▼
Read by QxMD icon Read
search

Beta adrenoceptor

keyword
https://www.readbyqxmd.com/read/27904493/beta-2-adrenergic-receptor-activation-enhances-neurogenesis-in-alzheimer-s-disease-mice
#1
Gao-Shang Chai, Yang-Yang Wang, Amina Yasheng, Peng Zhao
Impaired hippocampal neurogenesis is one of the early pathological features of Alzheimer's disease. Enhancing adult hippocampal neurogenesis has been pursued as a potential therapeutic strategy for Alzheimer's disease. Recent studies have demonstrated that environmental novelty activates β2-adrenergic signaling and prevents the memory impairment induced by amyloid-β oligomers. Here, we hypothesized that β2-adrenoceptor activation would enhance neurogenesis and ameliorate memory deficits in Alzheimer's disease...
October 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27885499/the-effects-of-alpha-1-adrenoceptor-blockade-and-angiotensin-converting-enzyme-inhibition-on-central-and-brachial-blood-pressure-and-vascular-reactivity-the-doxazosin-ramipril-study
#2
Andreas Jekell, Majid Kalani, Thomas Kahan
We aimed to study whether inhibition of the renin-angiotensin-aldosterone system has effects on vascular structure and function beyond the effects on blood pressure reduction alone. Patients with mild-to-moderate hypertension (n = 61, age 54 ± 12 years, 34% women) received the angiotensin converting enzyme inhibitor ramipril 10 mg or the alpha 1-adrenoceptor blocker doxazosin 8 mg double-blind for 12 weeks. Aortic blood pressure, pulse wave velocity, and augmentation index were assessed by applanation tonometry...
November 24, 2016: Heart and Vessels
https://www.readbyqxmd.com/read/27883118/cachexia
#3
A I Graul, M Stringer, L Sorbera
Cachexia is a multiorgan, multifactorial and often irreversible wasting syndrome associated with cancer and other serious, chronic illnesses including AIDS, chronic heart failure, chronic kidney disease and chronic obstructive pulmonary disease. Treatment of the patient with cachexia is currently targeted to correcting the two underlying features of the condition: anorexia and metabolic disturbances. Greater understanding of the mechanisms behind cachexia and muscle wasting have led to new therapeutic possibilities, however...
September 2016: Drugs of Today
https://www.readbyqxmd.com/read/27862262/different-effects-of-selective-%C3%AE-1-adrenoceptor-antagonists-nebivolol-or-atenolol-in-acetaminophen-induced-heptatotoxicity-of-rats
#4
Remon R Rofaeil, Maha Yehia Kamel, Walaa Yehia Abdelzaher
Acetaminophen (APAP) overdose is a common cause of acute liver failure and beta blockers are commonly used drugs in clinical practice. This study aims to evaluate the effect of two different beta blockers agents as nebivolol and atenolol against APAP-induced hepatotoxicity. Male wistar rats were treated with APAP (2 g/kg/day, p.o.) to induce hepatotoxicity. Our results showed that nebivolol and atenolol reduced heart rate and blood pressure. Nebivolol (5 mg/kg /day, p.o.) for 14 days has a hepatoprotective effect shown by significant decrease in hepatic injury parameters (serum AST and ALT) with significant suppression of hepatic malondialdehyde (MDA) and nitric oxide (NO) which were elevated with APAP administration...
November 14, 2016: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/27830686/-beta-adrenoceptor-mediated-cyclic-amp-signal-in-different-types-of-cultured-nerve-cells-in-normoxic-and-hypoxic-conditions
#5
M Jóźwiak-Bębenista, A Wiktorowska-Owczarek, E Kowalczyk
β-adrenergic neurotransmission is an important factor regulating brain activity such as neuronal and glial survival, plasticity, membrane transport or cellular metabolism. Intracellular β-adrenergic signaling, via a stimulatory G protein (Gs), activates two major down-stream effectors, i.e., adenylyl cyclase (AC) and cAMP-dependent protein kinase A (PKA). The aim of this work was to study the ability of endogenous (adrenaline and noradrenaline) and exogenous (isoprenaline) β-adrenergic receptor agonists to increase cAMP in different types of nerve cells...
September 2016: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/27823934/beta-adrenergic-signaling-affect-osteoclastogenesis-via-osteocytic-mlo-y4-cells-rankl-production
#6
Qianqian Yao, Hengxing Liang, Bo Huang, Lin Xiang, Tianlu Wang, Yi Xiong, Bo Yang, Yanjun Guo, Ping Gong
The sympathetic nervous system play a pivotal role in bone remodeling through β-adrenoceptor (β-AR). However, it is not well documented whether the β-adrenoceptor pathway has the potential to influence osteocytes. In this study, cell viability, the expression of β-AR subtypes, enzymes of catecholamine synthesis or degradation, bone-related gene and protein in osteocytic MLO-Y4 cells were investigated by β-adrenergic stimulation. Isoproterenol (ISO) promoted RANKL to OPG expression in osteocytes, as well as osteoclasts formation in osteocytes-RAW264...
November 4, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27794199/long-term-treatment-with-the-beta-3-adrenoceptor-agonist-mirabegron-ameliorates-detrusor-overactivity-and-restores-cyclic-adenosine-monophosphate-camp-levels-in-obese-mice
#7
Fabiano B Calmasini, Mariana G de Oliveira, Eduardo C Alexandre, Fábio H da Silva, Carmem P V da Silva, Tuany Z Candido, Edson Antunes, Fabíola Z Mónica
AIMS: To evaluate the effects of the beta-3 adrenoceptor agonist, mirabegron in a mouse model of detrusor overactivity induced by obesity. METHODS: C57BL/6 male mice were fed with standard chow or high-fat diet for 12 weeks. Lean and obese mice were treated orally with mirabegron (10 mg/kg/day) from the last 2 weeks of diet. Cystometric evaluations, functional assays, protein expression for phosphodiesterase type 4 (PDE4), and cyclic adenosine monophosphate (cAMP) measurement were carried out...
October 29, 2016: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/27759071/ucp2-expression-is-associated-with-weight-loss-after-hypocaloric-diet-intervention
#8
C Cortes-Oliveira, C F Nicoletti, M A de Souza Pinhel, B A P de Oliveira, D C G Quinhoneiro, N Y Noronha, J S Marchini, W A da Silva Júnior, W S Júnior, C B Nonino
BACKGROUND/OBJECTIVES: Although energy restriction contributes to weight loss, it may also reduce energy expenditure, limiting the success of weight loss in the long term. Studies have described how genetics contributes to the development of obesity, and uncoupling proteins 1 and 2 (UCP1 and UCP2) and beta-3-adrenoceptor (ADRB3) have been implicated in the metabolic pathways that culminate in this condition. This study aimed to evaluate how the UCP1, UCP2 and ADRB3 genes influence weight loss in severely obese women submitted to hypocaloric dietary intervention...
October 19, 2016: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27749467/agomelatine-a-new-opportunity-to-reduce-neuropathic-pain-preclinical-evidence
#9
Chouki Chenaf, Eric Chapuy, Frédéric Libert, Fabien Marchand, Christine Courteix, Marianne Bertrand, Cecilia Gabriel, Elisabeth Mocaër, Alain Eschalier, Nicolas Authier
Antidepressants are first-line treatments of neuropathic pain but not all of these drugs are really effective. Agomelatine is an antidepressant with a novel mode of action, acting as a MT1/MT2 melatonergic receptor agonist and a 5-HT2C receptor antagonist that involves indirect noradrenaline release. Melatonin, serotonin and noradrenaline have been involved in the pathophysiology of neuropathic pain. Yet no study has been conducted to determine agomelatine effects on neuropathic pain in animal models.Using three rat models of neuropathic pain of toxic (oxaliplatin/OXA), metabolic (streptozocin/STZ) and traumatic (sciatic nerve ligation/CCI) etiologies, we investigated the anti-hypersensitivity effect of acute and repeated agomelatine administration...
October 1, 2016: Pain
https://www.readbyqxmd.com/read/27717522/comparative-effectiveness-of-newer-medications-for-lower-urinary-tract-symptoms-attributed-to-benign-prostatic-hyperplasia-a-systematic-review-and-meta-analysis
#10
REVIEW
Philipp Dahm, Michelle Brasure, Roderick MacDonald, Carin M Olson, Victoria A Nelson, Howard A Fink, Bruce Rwabasonga, Michael C Risk, Timothy J Wilt
CONTEXT: Alpha-blockers (ABs) and 5-alpha reductase inhibitors have an established role in treating male lower urinary tract symptoms (LUTS) attributed to benign prostatic hyperplasia (BPH). Recently, newer drugs have shown promise for this indication. OBJECTIVE: To assess the comparative effectiveness and adverse effects (AEs) of newer drugs to treat LUTS attributed to BPH through a systematic review and meta-analysis. EVIDENCE ACQUISITION: Ovid MEDLINE, the Cochrane Central Register of Controlled Trials, and Ovid Embase bibliographic databases (through June 2016) were hand searches for references of relevant studies...
October 4, 2016: European Urology
https://www.readbyqxmd.com/read/27701011/further-evidence-for-a-role-of-the-adrb2-gene-in-risk-for-posttraumatic-stress-disorder
#11
Michael A Hauser, Melanie E Garrett, Yutao Liu, Michelle F Dennis, Nathan A Kimbrel, Veterans Affairs Mid-Atlantic Mental Illness Research Education And Clinical Center Workgroup, Jean C Beckham, Allison E Ashley-Koch
The aim of the present study was to attempt to replicate the recently reported finding associating rs2400707 of the Adrenoceptor Beta 2, Surface (ADRB2) gene and childhood trauma on PTSD symptoms. Participants included a predominantly veteran cohort of non-Hispanic blacks (NHB; n = 949) and a pre-dominantly veteran cohort of non-Hispanic whites (NHW; n = 759). No main effects were observed for rs2400707 on PTSD diagnosis. Among the NHB participants, we observed an interaction between rs2400707 and history of childhood trauma, whereby with each additional A allele, the odds of having PTSD increased by 1...
September 17, 2016: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/27582328/tunicamycin-induced-alterations-in-the-vasorelaxant-response-in-organ-cultured-superior-mesenteric-arteries-of-rats
#12
Takayuki Matsumoto, Makoto Ando, Shun Watanabe, Maika Iguchi, Mako Nagata, Shota Kobayashi, Kumiko Taguchi, Tsuneo Kobayashi
In cellular events, endoplasmic reticulum (ER) stress has an important role in the development of various diseases including cardiovascular diseases. Tunicamycin, an inhibitor of N-linked glycosylation, is known to be an inducer of ER stress. However, the extent to which tunicamycin affects the vasorelaxant function is not completely understood. Thus, we investigated the effect of tunicamycin on relaxations induced by various vasorelaxant agents, including acetylcholine (ACh; endothelium-dependent vasodilator), sodium nitroprusside (SNP; endothelium-independent vasodilator), isoprenaline (ISO; beta-adrenoceptor agonist), forskolin (FSK; adenylyl cyclase activator), and cromakalim [ATP-sensitive K(+) (KATP) channel activator] in organ-cultured superior mesenteric arteries of rats, which are treated with either a vehicle [dimethyl sulfoxide (DMSO)] or tunicamycin (20 µg/mL for 22-24 h)...
2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27528004/the-role-of-g%C3%AE-o-mediated-signaling-in-the-rostral-ventrolateral-medulla-oblongata-in-cardiovascular-reflexes-and-control-of-cardiac-ventricular-excitability
#13
Richard Ang, Joel Abramowitz, Lutz Birnbaumer, Alexander V Gourine, Andrew Tinker
The heart is controlled by the sympathetic and parasympathetic limbs of the autonomic nervous system with inhibitory signaling mechanisms recruited in both limbs. The aim of this study was to determine the role of inhibitory heterotrimeric G proteins in the central nervous mechanisms underlying autonomic control of the heart and its potential role in arrhythmogenesis. Mice with conditional deletion of the inhibitory heterotrimeric G protein GαO in the presympathetic area of the rostral ventral lateral medulla (RVLM) were generated to determine the role of GαO-mediated signalling in autonomic control and electrophysiological properties of the heart...
August 2016: Physiological Reports
https://www.readbyqxmd.com/read/27508642/-op-2d-07-the-effects-of-alpha-1-adrenoceptor-blockade-by-doxazosin-or-ace-inhibition-by-ramipril-on-endothelial-function-in-primary-hypertension-the-dora-study
#14
A Jekell, M Kalani, T Kahan
OBJECTIVE: To study whether reducing noradrenergic sympathetic vascular tone by doxazosin or blocking the renin-angiotensin-aldosterone system by ramipril will alter endothelial function in patients with uncomplicated hypertension. DESIGN AND METHOD: Mild-to-moderate hypertensive patients (age 54 ± 12 years, 34% women, blood pressure (BP) 148 ± 11/88 ± 9 mmHg) were randomized double-blind to ramipril (10 mg od, n = 33) or doxazosin (8 mg od, n = 28) for 12 weeks...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27502953/lead-modulates-calcium-entry-and-beta-adrenoceptors-signaling-to-produce-myometrial-relaxation-in-rats
#15
Udayraj P Nakade, Abhishek Sharma, Soumen Choudhury, Rajkumar Singh Yadav, Satish Kumar Garg
Modulation of myometrial spontaneity by lead acetate trihydrate (Pb) and its regulatory pathways were studied in estrogenized rats. Isometric tension in myometrial strips under a resting tension of 1 g was measured using data acquisition system-based physiograph and Lab Chart Pro v7.3.7 software. Lead produced a dose-dependent inhibitory effect on rat myometrium with a major effect on phasic contractions compared to tonic contractions along with a reduction in both amplitude and frequency of contraction. Lead (3 μM) significantly (p < 0...
August 9, 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/27498750/gas-phase-ultraviolet-and-infrared-spectroscopy-on-a-partial-peptide-of-%C3%AE-2-adrenoceptor-sivsf-nh2-by-a-laser-desorption-supersonic-jet-technique
#16
Shun-Ichi Ishiuchi, Kohei Yamada, Hikari Oba, Hiromichi Wako, Masaaki Fujii
Laser desorption supersonic jet laser spectroscopy has been applied to a penta-peptide, Ser-Ile-Val-Ser-Phe-NH2 (SIVSF-NH2), which is a partial sequence of a binding site in a β2-adrenaline receptor protein. By comparing the resonance enhanced multiphoton ionization spectrum with the ultraviolet-ultraviolet hole burning (HB) spectrum, it is concluded that only a single conformer exists. The infrared (IR) spectrum of the X-H stretching region, measured by IR dip spectroscopy, shows that all of the OH and NH groups form hydrogen bonds...
August 17, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27442692/beta-adrenoceptors-in-obstetrics-and-gynecology
#17
REVIEW
Beata Modzelewska
One hundred and twenty years after the description of extracts from the adrenal medulla, the use of beta-blockers and beta-agonists evolved from antianginal drugs and tocolytics to ligand-directed signaling. Beta-blockers in the fields of obstetrics and gynecology have so far been limited to the consideration of continuing treatment of disorders of the cardiovascular system and other dysfunctions that started before pregnancy. Studies in recent years have shown that beta-adrenoceptor signaling might be crucial in carcinogenesis and metastasis, apoptosis and anoikis...
April 2016: Developmental Period Medicine
https://www.readbyqxmd.com/read/27403604/the-%C3%AE-2-adrenoceptor-agonist-terbutaline-stimulates-angiogenesis-via-akt-and-erk-signaling
#18
Stefanie Lemmens, Lauren Kusters, Annelies Bronckaers, Nathalie Geurts, Sven Hendrix
Angiogenesis is associated with changes in endothelial cell (EC) proliferation and tube formation, controlled by extracellular receptor-activated kinase (ERK)/mitogen activated protein kinase (MAPK) and Akt signaling. Important regulators of these systems include hormones acting on G-protein-coupled receptors, such as beta 2-adrenoceptors (β2-ARs). In central nervous system (CNS) trauma, the importance of β2-AR modulation has been highlighted, although the effects on revascularization remain unclear. Vascular protection and revascularization are, however, key to support regeneration...
July 12, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27400929/%C3%AE-adrenergic-receptor-gene-expression-in-hiv-associated-neurocognitive-impairment-and-encephalitis-implications-for-mor-1k-subcellular-localization
#19
Seth M Dever, Myosotys Rodriguez, Nazira El-Hage
We previously reported that mRNA expression of the unique alternatively spliced OPRM1 isoform μ-opioid receptor-1K (MOR-1K), which exhibits excitatory cellular signaling, is elevated in HIV-infected individuals with combined neurocognitive impairment (NCI) and HIV encephalitis (HIVE). It has recently been shown that the β2-adrenergic receptor (β2-AR) chaperones MOR-1K, normally localized intracellularly, to the cell surface. Here, we found mRNA expression of the adrenoceptor beta 2 (ADRB2) gene is also elevated in NCI-HIVE individuals, as well as that β2-AR protein expression is elevated in HIV-1-infected primary human astrocytes treated with morphine, and discuss the implications for MOR-1K subcellular localization in this condition...
December 2016: Journal of Neurovirology
https://www.readbyqxmd.com/read/27396805/pharmacological-modification-of-the-perioperative-stress-response-in-noncardiac-surgery
#20
REVIEW
Hans-Joachim Priebe
The perioperative period is associated with alterations in the neuroendocrine, metabolic, and immune systems, referred to as "stress response." The resultant increased sympathetic activity and elevated serum concentrations of catecholamines may adversely affect the cardiovascular system, resulting in cardiovascular instability (hypertension, tachycardia, and arrhythmia), morbidity (myocardial ischemia, myocardial infarction, and stroke), and mortality (cardiac death and fatal stroke), particularly in patients at an elevated cardiovascular risk and with reduced cardiovascular reserve...
June 2016: Best Practice & Research. Clinical Anaesthesiology
keyword
keyword
31915
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"