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Beta adrenergic receptor

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https://www.readbyqxmd.com/read/29670675/adrb2-arg16gly-polymorphism-and-pulmonary-function-response-of-inhaled-corticosteroids-plus-long-acting-beta-agonists-for-asthma-treatment-a-systematic-review-and-meta-analysis
#1
REVIEW
Xi Wang, Qian Li, Ruming Liu, Jin He, Di Wu, Yun Wang, Jun Zhang
Background: The beta-2 adrenergic receptor (ADRB2) Arg16Gly polymorphism may alter the bronchodilation response to long-acting beta2-agonists, thereby influencing the clinical effectiveness of LABAs plus corticosteroids (ICS) treatment. But the results of individual studies are inconclusive. Methods: A systematic search was conducted in PubMed, Embase, the Cochrane Database, WHO International Clinical Trials Registry Platform, Chinese National Knowledge Infrastructure, Wanfang, Chinese BioMedical Literature Database, and VIP databases...
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/29661693/phosphorylation-of-beta-3-adrenergic-receptor-at-serine-247-by-erk-map-kinase-drives-lipolysis-in-obese-adipocytes
#2
Shangyu Hong, Wei Song, Peter-James H Zushin, Bingyang Liu, Mark P Jedrychowski, Amir I Mina, Zhaoming Deng, Dimitrije Cabarkapa, Jessica A Hall, Colin J Palmer, Hassan Aliakbarian, John Szpyt, Steven P Gygi, Ali Tavakkoli, Lydia Lynch, Norbert Perrimon, Alexander S Banks
OBJECTIVE: The inappropriate release of free fatty acids from obese adipose tissue stores has detrimental effects on metabolism, but key molecular mechanisms controlling FFA release from adipocytes remain undefined. Although obesity promotes systemic inflammation, we find activation of the inflammation-associated Mitogen Activated Protein kinase ERK occurs specifically in adipose tissues of obese mice, and provide evidence that adipocyte ERK activation may explain exaggerated adipose tissue lipolysis observed in obesity...
March 29, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29652832/sympathetic-nerve-hyperactivity-in-the-spleen-causal-for-nonpathogenic-driven-chronic-immune-mediated-inflammatory-diseases-imids
#3
REVIEW
Denise L Bellinger, Dianne Lorton
Immune-Mediated Inflammatory Diseases (IMIDs) is a descriptive term coined for an eclectic group of diseases or conditions that share common inflammatory pathways, and for which there is no definitive etiology. IMIDs affect the elderly most severely, with many older individuals having two or more IMIDs. These diseases include, but are not limited to, type-1 diabetes, obesity, hypertension, chronic pulmonary disease, coronary heart disease, inflammatory bowel disease, and autoimmunity, such as rheumatoid arthritis (RA), Sjőgren's syndrome, systemic lupus erythematosus, psoriasis, psoriatic arthritis, and multiple sclerosis...
April 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29615619/pharmacologically-induced-amnesia-for-learned-fear-is-time-and-sleep-dependent
#4
Merel Kindt, Marieke Soeter
The discovery in animal research that fear memories may change upon retrieval has sparked a wave of interest into whether this phenomenon of reconsolidation also occurs in humans. The critical conditions under which memory reconsolidation can be observed and targeted in humans, however, remain elusive. Here we report that blocking beta-adrenergic receptors in the brain, either before or after reactivation, effectively neutralizes the expression of fear memory. We show a specific time-window during which beta-adrenergic receptors are involved in the reconsolidation of fear memory...
April 3, 2018: Nature Communications
https://www.readbyqxmd.com/read/29608501/through-the-decades-%C3%AE-blocker-use-and-outcomes-in-acute-coronary-syndromes
#5
Alina Kukin, Zachary R Noel, Kristin Watson
Beta-adrenergic receptor antagonists, or β-blockers, have been a cornerstone of treatment in patients with acute coronary syndromes (ACS) for more than 4 decades. First studied in the 1960s, β-blockers in ACS have been shown to decrease the risk of death, recurrent ischemic events, and arrhythmias by reducing catecholamine-mediated effects and reducing myocardial oxygen demand. Through the decades, the β-blocker of choice, timing of initiation, duration of therapy, and dosing have evolved considerably. Despite having clear benefits in certain patient populations (eg, patients with systolic dysfunction who are hemodynamically stable), the benefit of β-blockers in other populations (ie, in patients at low risk for complications receiving modern revascularization therapies and optimal medical management) remains unclear...
May 2018: Cardiology in Review
https://www.readbyqxmd.com/read/29606859/-ppargamma-2-and-adrb3-polymorphisms-in-connective-tissue-diseases-and-lipid-disorders
#6
Bogna Grygiel-Górniak, Iwona Ziółkowska-Suchanek, Elżbieta Kaczmarek, Maria Mosor, Jerzy Nowak, Mariusz Puszczewicz
Background: The aim of the research genetic study was to investigate the association between variants (C1431T and Pro12Ala) of the peroxisome proliferator-activated receptor ( PPARgamma-2 ) gene, Trp64Arg polymorphism of the beta-3-adrenergic receptor gene and lipid profile in Polish population including group of 103 patients with connective tissue disease (CTD) and 103 sex-and age-matched controls in context of statin use. Methods: Anthropometric and biochemical parameters were measured by routine methods, followed by genotyping (TagMan® Genotyping Assays, PCR-restriction fragment length polymorphism analysis)...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29599420/brown-adipose-tissue-whitening-leads-to-brown-adipocyte-death-and-adipose-tissue-inflammation
#7
Petra Kotzbeck, Antonio Giordano, Eleonora Mondini, Incoronata Murano, Ilenia Severi, Wiebe Venema, Maria Paola Cecchini, Erin E Kershaw, Giorgio Barbatelli, Guenter Haemmerle, Rudolf Zechner, Saverio Cinti
In mammals, white adipose tissue (WAT) stores and releases lipids, whereas brown adipose tissue (BAT) oxidizes lipids to fuel thermogenesis. In obese individuals WAT undergoes profound changes; it expands, becomes dysfunctional, and develops a low-grade inflammatory state. Importantly, BAT content and activity decline in obese subjects, mainly as a result of the conversion of brown adipocytes to white-like unilocular cells. Here, we show that BAT ″whitening″ is induced by multiple factors, including high ambient temperature, leptin receptor deficiency, beta-adrenergic signaling impairment, and lipase deficiency, each of which is capable of inducing macrophage infiltration, brown adipocyte death, and crown-like structure (CLS) formation...
March 29, 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/29588232/the-effect-of-beta-adrenergic-blockade-on-inflammatory-and-cardiovascular-responses-to-acute-mental-stress
#8
Andrew Steptoe, Amy Ronaldson, Karen Kostich, Antonio Lazzarino, Livia Urbanova, Livia A Carvalho
Acute mental stress elicits increases in plasma cytokine concentrations in humans, but the underlying mechanisms remain poorly understood. We assessed the impact of beta-adrenergic blockade on plasma interleukin 6 (IL-6) and IL-1 receptor antagonist (IL-1Ra) responses in a parallel group, double-blind randomised placebo-controlled trial involving 64 healthy young adult volunteers. Participants were administered 80mg slow-release propranolol or placebo daily for 7 days before the stress testing session in which responses to 3 behavioural challenges (public speaking, mirror tracing, mental arithmetic) were evaluated...
March 24, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29584915/interleukin-1-blockade-in-cardiovascular-diseases-a-clinical-update
#9
Leo F Buckley, Antonio Abbate
Interleukin-1 (IL-1) is the prototypical pro-inflammatory cytokine. IL-1 was implicated as a cardiodepressant factor in septic shock, and subsequent pre-clinical and clinical research has defined important roles for IL-1 in atherosclerosis, acute myocardial infarction (AMI), and heart failure (HF). IL-1 promotes the formation of the atherosclerotic plaque and facilitates its progression and complication. In a large phase III clinical trial of stable patients with prior AMI, blocking IL-1 activity using a monoclonal antibody prevented recurrent atherothrombotic cardiovascular events...
March 23, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29580170/comparison-of-therapeutic-triiodothyronine-versus-metoprolol-in-treatment-of-myocardial-infarction-in-rats
#10
Kuo Zhang, Yi-Da Tang, Youhua Zhang, Kaie Ojamaa, Ying Li, Amandeep Singh Saini, Maria Alicia Carrillo-Sepulveda, Viswanathan Rajagopalan, A Martin Gerdes
BACKGROUND: Beta blockers are standard therapy for myocardial infarction (MI). Preclinical studies have shown efficacy and safety of thyroid hormone (TH) treatment of cardiovascular disorders. Since THs interact with the sympathoadrenergic system, we aimed to compare triiodothyronine (T3) and metoprolol (Met) treatment of rats with MI on pathophysiology and TH-adrenergic signaling. METHODS: Female Sprague-Dawley rats aged 12 weeks underwent left anterior descending coronary artery ligation (MI) or sham surgeries...
March 26, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29573550/relative-quantification-of-beta-adrenergic-receptor-in-peripheral-blood-cells-using-flow-cytometry
#11
Didem Saygin, Nicholas Wanner, Jonathan A Rose, Sathyamangla V Naga Prasad, W H Wilson Tang, Serpil Erzurum, Kewal Asosingh
Beta-adrenergic receptors (β-ARs) play a critical role in many diseases. Quantification of β-AR density may have clinical implications in terms of assessing disease severity and identifying patients who could potentially benefit from beta-blocker therapy. Classical methods for β-AR quantification are based on labor-intensive and time-consuming radioligand binding assays. Here, we report optimization of a flow cytometry-based method utilizing a biotinylated β-AR ligand alprenolol as a probe and use of this method to quantify relative receptor expression in healthy controls (HC)...
March 24, 2018: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/29569954/nitrosative-stress-uncovers-potent-%C3%AE-2-adrenergic-receptor-linked-vasodilation-further-enhanced-by-blocking-clathrin-endosome-formation
#12
Mary D Frame, Anthony M Dewar, Rhodora C Calizo, Adroniqui Qifti, Suzanne F Scarlata
This study investigated the effect of nitroprusside (SNP) pre-exposure on vasodilation via the beta-adrenergic receptor system. SNP was used as a nitrosative / oxidative pro-inflammatory insult. Small arterioles were visualized by intravital microscopy in the hamster cheek pouch tissue (isoflurane, N=45). Control dilation to isoproterenol (EC50 10-7 mol/L) became bi-phasic as a function of concentration following 2 min exposure to SNP (10-4 M), with a pico-molar dilation uncovered, and the micro-molar dilation attenuated...
March 23, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29552696/mechanism-of-vasorelaxation-induced-by-3-hydroxy-5-6-7-4-tetramethoxyflavone-in-the-rats-aortic-ring-assay
#13
Chu Shan Tan, Mun Fei Yam
Previous studies have demonstrated that 3'-hydroxy-5,6,7,4'-tetramethoxyflavone (TMF) content in Orthosiphon stamineus fractions correlate with its vasorelaxation activity. Even with the availability of previous studies, there is still very little information on the vasorelaxation effect of TMF, and few scientific studies have been carried out. Therefore, the present study was designed to investigate the vasorelaxation activity and mechanism of action of the TMF. The vasorelaxation activity and the underlying mechanisms of TMF were evaluated on thoracic aortic rings isolated from Sprague Dawley rats...
March 19, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29548536/inferential-characterization-of-the-dose-response-relationships-of-neurohormonal-antagonists-in-chronic-heart-failure-a-novel-approach-based-on-large-scale-trials-with-active-comparators
#14
REVIEW
Milton Packer
BACKGROUND: Current guidelines for the treatment of heart failure strongly recommend the use of inhibitors of the renin-angiotensin system and sympathetic nervous system in all patients with a reduced ejection fraction who can tolerate these drugs. Yet, there is no consensus about the efficacy of low doses of these drugs or the likely shape of the dose-response relationship for these agents. METHODS: Inferences were made by examining the effects of drugs in placebo-controlled trials before the protocol-specified opportunity for uptitration and by reassessing the results of large-scale trials with active comparators that inadvertently produced different intensities of neurohormonal blockade...
March 11, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29478130/ccl2-induces-the-production-of-%C3%AE-2-adrenergic-receptors-and-modifies-astrocytic-responses-to-noradrenaline
#15
Irene L Gutiérrez, Marta González-Prieto, Borja García-Bueno, Javier R Caso, Douglas L Feinstein, José L M Madrigal
The decline in brain noradrenaline levels is associated with the progression of certain neurodegenerative diseases. This seems to be due, at least in part, to the ability of noradrenaline to limit glial activation and to reduce the damage associated with it. Our previous studies of the mechanisms involved in this process indicate that noradrenaline induces the production of the chemokine CCL2 in astrocytes. While CCL2 can protect neurons against certain injuries, its overproduction has also proven to be harmful and to prevent noradrenaline neuroprotective effects...
February 24, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29474096/theranostic-radiopharmaceuticals-established-agents-in-current-use
#16
James R Ballinger
Although use of the term "theranostic" is relatively recent, the concept goes back to the earliest days of nuclear medicine, with the use of radioiodine for diagnosis and therapy of benign and malignant thyroid disease being arguably the most successful molecular radiotherapy in history. A diagnostic scan with 123 I-, 124 I-, or a low activity of 131 I-iodide is followed by therapy with high activity 131 I-iodide. Similarly, adrenergic tumours such as phaeochromocytoma and neuroblastoma can be imaged with 123 I-metaiodobenzylguanidine and treated with 131 I-metaiodobenzylguanidine...
March 12, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29464546/gene-diet-related-factors-of-hyperglycaemia-in-postmenopausal-women
#17
Bogna Grygiel-Górniak, Elżbieta Kaczmarek, Maria Mosor, Juliusz Przysławski, Jerzy Nowak
As ageing and increased body fat are the signs of insulin resistance, we have studied whether the presence of Pro12Ala and C1431T of peroxisome proliferator-activated receptor gamma 2 gene and Trp64Arg of beta 3-adrenergic receptor gene may predispose to the hyperglycaemia development in postmenopausal women, who have never undergone hypoglycaemic treatment. The distributions of selected allele and genotype frequencies were determined by the PCR-RFLP method in normo- and hyperglycaemic, who have never been diagnosed and treated for diabetes mellitus were measured...
February 20, 2018: Journal of Applied Genetics
https://www.readbyqxmd.com/read/29462491/the-beta-adrenergic-agonist-salbutamol-modulates-neuromuscular-junction-formation-in-zebrafish-models-of-human-myasthenic-syndromes
#18
Grace McMacken, Dan Cox, Andreas Roos, Juliane Müller, Roger Whittaker, Hanns Lochmüller
Inherited defects of the neuromuscular junction (NMJ) comprise an increasingly diverse range of disorders, termed congenital myasthenic syndromes (CMS). Therapies acting on the sympathetic nervous system, including the selective β2 adrenergic agonist salbutamol and the α and β adrenergic agonist ephedrine, have become standard treatment for several types of CMS. However, the mechanism of the therapeutic effect of sympathomimetics in these disorders is not understood. Here, we examined the effect of salbutamol on NMJ development using zebrafish with deficiency of the key postsynaptic proteins Dok-7 and MuSK...
February 16, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29456602/review-of-management-in-cardiotoxic-overdose-and-efficacy-of-delayed-intralipid-use
#19
Edward Walter, James McKinlay, Jade Corbett, Justin Kirk-Bayley
We present the case of a 51-year-old woman admitted to our intensive care unit following an intentional overdose of a calcium channel antagonist and a beta blocker. The resultant hypotension was reversed with glucagon, noradrenaline, calcium and high-dose insulin. Despite these interventions, she remained vasoplegic and received a delayed, standard dose of intralipid. Subsequently, the vasoplegia resolved rapidly, and the vasopressor was stopped. Here, we review the management of overdose of calcium channel and beta-adrenergic receptor blockers, concentrating on the pharmacology of lipid emulsion therapy...
February 2018: Journal of the Intensive Care Society
https://www.readbyqxmd.com/read/29455206/a-potential-mechanism-for-immune-suppression-by-beta-adrenergic-receptor-stimulation-following-traumatic-injury
#20
Nicholas J Shubin, Tam N Pham, Kristan Lea Staudenmayer, Brodie A Parent, Qian Qiu, Grant E O'Keefe
BACKGROUND: β-Adrenergic agents suppress inflammation and may play an important role in posttraumatic infections. Mechanisms may include inhibition of MAP kinase signaling. We sought to determine whether MKP-1 contributed to catecholamine suppression of innate immunity and also wanted to know whether early catecholamine treatment after traumatic injury increases the risk of later nosocomial infection. METHODS: We performed experiments using THP-1 cells and peripheral blood mononuclear cells from healthy individuals...
February 16, 2018: Journal of Innate Immunity
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