Xuelei Ruan, Yunhui Liu, Ping Wang, Libo Liu, Teng Ma, Yixue Xue, Weiwei Dong, Yubo Zhao, Tiange E, Hongda Lin, Di Wang, Chunqing Yang, Jian Song, Jiate Liu, Meiqi Deng, Ping An, Yang Lin, Jin Yang, Zheng Cui, Yaming Cao, Xiaobai Liu
Glioblastoma multiforme (GBM) is a highly vascularized malignant cancer of the central nervous system, and the presence of vasculogenic mimicry (VM) severely limits the effectiveness of anti-vascular therapy. In this study, we identified downregulated circHECTD1, which acted as a key VM-suppressed factor in GBM. circHECTD1 elevation significantly inhibited cell proliferation, migration, invasion and tube-like structure formation in GBM. RIP assay was used to demonstrate that the flanking intron sequence of circHECTD1 can be specifically bound by RBMS3, thereby inducing circHECTD1 formation to regulate VM formation in GBM...
November 15, 2023: Cell Death & Disease