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Vasculogenic mimicry

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https://www.readbyqxmd.com/read/29780735/the-expression-and-functional-significance-of-vascular-endothelial-cadherin-cd44-and-vimentin-in-oral-squamous-cell-carcinoma
#1
Soussan Irani, Arash Dehghan
Objectives: Ninety percent of head and neck cancers are squamous cell carcinoma which develops in the oral cavity. Metastasis is the main causative factor for death in 90% of all cancer-related deaths and begins with the invasion of tumor cells through the walls of small blood vessels or lymph vessels. A growing body of evidence has shown that vasculogenic mimicry (VM) facilitates tumor growth and cancer metastasis. The current study aimed to present the role of vascular endothelial (VE)-cadherin, CD44, and vimentin in inducing VM and epithelial-mesenchymal transition (EMT) and to identify the cancer stem cell (CSC) niche in different grades of oral squamous cell carcinoma (OSCC)...
March 2018: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/29754422/zeb1-mediated-vasculogenic-mimicry-formation-associates-with-epithelial-mesenchymal-transition-and-cancer-stem-cell-phenotypes-in-prostate-cancer
#2
Hua Wang, Bin Huang, Bai Mou Li, Kai Yuan Cao, Chen Qiang Mo, Shuang Jian Jiang, Jin Cheng Pan, Zong Ren Wang, Huan Yi Lin, Dao Hu Wang, Shao Peng Qiu
The zinc finger E-box-binding homeobox 1 (ZEB1) induced the epithelial-mesenchymal transition (EMT) and altered ZEB1 expression could lead to aggressive and cancer stem cell (CSC) phenotypes in various cancers. Tissue specimens from 96 prostate cancer patients were collected for immunohistochemistry and CD34/periodic acid-Schiff double staining. Prostate cancer cells were subjected to ZEB1 knockdown or overexpression and assessment of the effects on vasculogenic mimicry formation in vitro and in vivo. The underlying molecular events of ZEB1-induced vasculogenic mimicry formation in prostate cancer were then explored...
May 12, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29750896/migration-inducing-gene-7-independently-predicts-poor-prognosis-of-human-osteosarcoma-and-is-associated-with-vasculogenic-mimicry
#3
Ke Ren, Jian Zhang, Xiaojie Gu, Sujia Wu, Xin Shi, Yicheng Ni, Yong Chen, Jun Lu, Zengxin Gao, Chen Wang, Nan Yao
Vasculogenic mimicry (VM) is a special type of vascular channel formed by tumor cells without endothelial cell participation. Migration-inducing gene 7 (MIG-7) plays an important role in regulating VM. In this study, immunohistochemical staining was used to detect MIG-7 in tissue specimens from 141 primary osteosarcoma patients, and the relationship between MIG-7 and VM was examined. Survival analysis were performed to evaluate the prognoses. MIG-7 knockdown osteosarcoma cells were used for cell proliferation, apoptosis, migration, invasiveness and VM formation assays...
May 8, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29749553/ebv%C3%A2-lmp1-is-involved-in-vasculogenic-mimicry-formation-via-vegfa-vegfr1-signaling-in-nasopharyngeal-carcinoma
#4
San Xu, Ju Bai, Zhou Zhuan, Bo Li, Zhibao Zhang, Xia Wu, Xiangjian Luo, Lifang Yang
The Epstein-Barr virus latent membrane protein 1 (EBV‑LMP1) is an oncoviral protein that plays an important role in oncogenic transformation in EBV‑associated nasopharyngeal carcinoma (NPC). Our previous studies demonstrated that LMP1 increased VEGFA expression and upregulated angiogenesis in NPC. Vasculogenic mimicry (VM) is a mechanism by which tumor cells can obtain nutrients to survive, and VM has been observed in numerous types of tumors. However, the occurrence and significance of VM in NPC and the relationship between LMP1 and VM have not yet been evaluated...
May 3, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29749455/anti%C3%A2-metastatic-effects-of-aidi-on-human-esophageal-squamous-cell-carcinoma-by-inhibiting-epithelial%C3%A2-mesenchymal-transition-and-angiogenesis
#5
Qingtong Shi, Yali Diao, Feng Jin, Zhiyan Ding
Aidi injection, a proprietary Chinese medicine, has been widely used for the treatment of cancer. However, its effects and potential mechanism in esophageal squamous cell carcinoma (ESCC) have not yet been characterized. The aim of the present study was to identify the mechanism underlying the anti‑metastatic effects of treatment with Aidi. To test the effects and mechanism, EC9706 and KYSE70 cells were selected for in vitro experiments. In vivo, the anti‑metastatic effects of Aidi injection on a nude mouse peritoneal metastasis model were examined, and the mechanisms were assessed with immunohistochemical staining...
May 4, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29725496/melatonin-inhibits-reactive-oxygen-species-driven-proliferation-epithelial-mesenchymal-transition-and-vasculogenic-mimicry-in-oral-cancer
#6
Rui Liu, Hui-Li Wang, Man-Jing Deng, Xiu-Jie Wen, Yuan-Yuan Mo, Fa-Ming Chen, Chun-Li Zou, Wei-Feng Duan, Lei Li, Xin Nie
Globally, oral cancer is the most common type of head and neck cancers. Melatonin elicits inhibitory effects on oral cancer; however, the biological function of melatonin and underlying mechanisms remain largely unknown. In this study, we found that melatonin impaired the proliferation and apoptosis resistance of oral cancer cells by inactivating ROS-dependent Akt signaling, involving in downregulation of cyclin D1, PCNA, and Bcl-2 and upregulation of Bax. Melatonin inhibited the migration and invasion of oral cancer cells by repressing ROS-activated Akt signaling, implicating with the reduction of Snail and Vimentin and the enhancement of E-cadherin...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29693713/low-nr3c2-levels-correlate-with-aggressive-features-and-poor-prognosis-in-non-distant-metastatic-clear-cell-renal-cell-carcinoma
#7
Zhijian Zhao, Mengping Zhang, Xiaolu Duan, Tuo Deng, Huijuan Qiu, Guohua Zeng
NR3C2 has previously been described as a tumor suppressor gene in several cancers; however the prognostic significance and biological function of NR3C2 in patients with non-metastatic clear cell renal cell carcinoma (ccRCC) remain largely unclear. The prognostic value of NR3C2 expression was evaluated using data from The Cancer Genome Atlas (TCGA) and 181 patients with non-metastatic ccRCC undergoing nephrectomy in our center. Predictive nomograms were generated and identified independent prognosticators to assess ccRCC patient overall survival (OS) and progression free survival (PFS) at 1, 5, and 8 years...
April 25, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29693128/a-novel-monoclonal-antibody-targeting-a-novel-epitope-of-ve%C3%A2-cadherin-inhibits-vasculogenic-mimicry-of-lung-cancer-cells
#8
Jie Ding, Xi Jia, Bin Zuo, Jun He, Jianfeng Yang, Yang He
Vascular endothelial cadherin (VE‑cadherin) was first found in vascular endothelial cells to maintain normal vascular structures and regulate endothelial cell permeability by homology adhesion. New evidence indicates that certain invasive tumor cells also express VE‑cadherin, which is involved in vasculogenic mimicry to provide a blood supply required for tumor growth and metastasis. EC1 and EC3 domains of VE‑cadherin were reported to be important for intercellular homology adhesion. In the present study, a monoclonal antibody specific to the outer-membrane immunoglobulin-like domains of VE‑cadherin was generated and the binding epitope was identified as peptide LDREVVPWYNLTVEA in the EC4 domain...
April 16, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29684697/new-arene-ruthenium-ii-complexes-of-4%C3%A2-aryl%C3%A2-4h%C3%A2-naphthopyrans-with-anticancer-and-anti-vascular-activities
#9
Florian Schmitt, Jana Kasparkova, Viktor Brabec, Gerrit Begemann, Rainer Schobert, Bernhard Biersack
A series of four 2‑amino‑3‑cyano‑4‑(3/4‑pyridyl)‑4H‑benzo[h]chromenes 2a-d and their dichlorido(p‑cymene)ruthenium(II) complexes 3a-d were tested for antiproliferative, vascular-disruptive, anti-angiogenic and DNA-binding activity. The coordination of the 4‑pyridyl‑4H‑naphthopyrans 2 to ruthenium led to complexes with pleiotropic effects. Unlike the free ligands 2a-d, their ruthenium complexes 3a-d showed a significant affinity for DNA as demonstrated by electrophoretic mobility shift assays (EMSA) and ethidium bromide assays...
April 5, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29679668/a-novel-peptide-ligand-rap12-of-lrp1-for-glioma-targeted-drug-delivery
#10
Huitong Ruan, Zhilan Chai, Qing Shen, Xishan Chen, Bingxia Su, Cao Xie, Changyou Zhan, Shengyu Yao, Huan Wang, Mingfei Zhang, Man Ying, Weiyue Lu
The receptor associated protein (RAP) is a 39 kDa chaperone protein, binding tightly to low-density lipoprotein receptor-related protein-1 (LRP1) that is overexpressed in glioma, tumor neovasculature, vasculogenic mimicry (VM), the blood-brain barrier (BBB) and the blood-brain tumor barrier (BBTB). Herein, we miniaturized the RAP protein into a short peptide RAP12 (EAKIEKHNHYQK) aiding by computer-aided peptide design technique. RAP12 contained the essential lysines at the positions 253 and 256. The binding affinity of RAP12 to LRP1 was theoretically and experimentally evaluated...
April 18, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29660229/extracellular-matrix-composition-modulates-pdac-parenchymal-and-stem-cell-plasticity-and-behavior-through-the-secretome
#11
Giulia Biondani, Katrine Zeeberg, Maria Raffaella Greco, Stefania Cannone, Ilaria Dando, Elisa Dalla Pozza, Maria Mastrodonato, Stefania Forciniti, Valeria Casavola, Marta Palmieri, Stephan Joel Reshkin, Rosa Angela Cardone
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers. Its aggressiveness is driven by an intense fibrotic desmoplastic reaction in which the increasingly collagen I-rich extracellular matrix (ECM) and several cell types, including cancer stem cells (CSCs), create a tumor-supportive environment. However, how ECM composition regulates CSC dynamics and their relationship to the principal parenchymal tumor population to promote early invasive growth is not yet characterized. For this we utilized a platform of 3D organotypic cultures composed of laminin-rich Matrigel, representative of an early tumor, plus increasing concentrations of collagen I to simulate malignant stroma progression...
April 16, 2018: FEBS Journal
https://www.readbyqxmd.com/read/29587825/inflammatory-interferon-activates-hif-1%C3%AE-mediated-epithelial-to-mesenchymal-transition-via-pi3k-akt-mtor-pathway
#12
Yen-Hsiu Yeh, Ho-Fu Hsiao, Yen-Cheng Yeh, Tien-Wen Chen, Tsai-Kun Li
BACKGROUND: Tumor microenvironments (TMEs) activate various axes/pathways, predominantly inflammatory and hypoxic responses, impact tumorigenesis, metastasis and therapeutic resistance significantly. Although molecular pathways of individual TME are extensively studied, evidence showing interaction and crosstalk between hypoxia and inflammation remain unclear. Thus, we examined whether interferon (IFN) could modulate both inflammatory and hypoxic responses under normoxia and its relation with cancer development...
March 27, 2018: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29576623/optoacoustics-delineates-murine-breast-cancer-models-displaying-angiogenesis-and-vascular-mimicry
#13
Isabel Quiros-Gonzalez, Michal R Tomaszewski, Sarah J Aitken, Laura Ansel-Bollepalli, Leigh-Ann McDuffus, Michael Gill, Lina Hacker, Joanna Brunker, Sarah E Bohndiek
BACKGROUND: Optoacoustic tomography (OT) of breast tumour oxygenation is a promising new technique, currently in clinical trials, which may help to determine disease stage and therapeutic response. However, the ability of OT to distinguish breast tumours displaying different vascular characteristics has yet to be established. The aim of the study is to prove OT as a sensitive technique for differentiating breast tumour models with manifestly different vasculatures. METHODS: Multispectral OT (MSOT) was performed in oestrogen-dependent (MCF-7) and oestrogen-independent (MDA-MB-231) orthotopic breast cancer xenografts...
March 26, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29561011/hypotoxic-copper-complexes-with-potent-anti-metastatic-and-anti-angiogenic-activities-against-cancer-cells
#14
Xiangchao Shi, Zhongyan Chen, Yanjun Wang, Zijian Guo, Xiaoyong Wang
Tumor metastasis and angiogenesis are the major obstacles in anticancer therapy. A series of phenanthroline copper(ii) complexes with different alkyl chains (CPTn, n = 1, 4, 6, 8) are synthesized and characterized. Cellular uptake and cytotoxicity assays reveal that the complex with longer chain length exhibits higher cellular Cu accumulation and stronger inhibition against the cancer cells. Both lipophilicity and structure influence the cellular uptake and cytotoxicity of CPTn. CPT8 is the most potent complex in this series...
March 21, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29552157/vasculogenic-mimicry-in-bladder-cancer-and-its-association-with-the-aberrant-expression-of-zeb1
#15
Baimou Li, Xiaopeng Mao, Hua Wang, Guanyu Su, Chengqiang Mo, Kaiyuan Cao, Shaopeng Qiu
The aim of the present study was to investigate the associations between vasculogenic mimicry (VM) and zinc finger E-box binding homeobox 1 (ZEB1) in bladder cancer. VM structure and ZEB1 expression were analyzed by cluster of differentiation 34/periodic acid Schiff (PAS) double staining and immunohistochemical staining in 135 specimens from patients with bladder cancer, and a further 12 specimens from normal bladder tissues. Three-dimensional (3-D) culture was used to detect VM formation in the bladder transitional cancer cell lines UM-UC-3 and J82, and the immortalized human bladder epithelium cell line SV-HUC-1 in vitro ...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29552129/effect-of-galectin-3-on-vasculogenic-mimicry-in-esophageal-cancer-cells
#16
Jingxin Zhang, Guodong Deng, Lili Qiao, Hui Luo, Qiqi Liu, Ning Liang, Jian Xie, Jiandong Zhang
Galectin-3 is a multifunctional β-galactoside binding lectin associated with tumor progression. Previous studies confirmed the roles of galecin-3 overexpression and silencing in the biological behavior of Eca109 human esophageal cancer (EC) cells; galectin-3 may serve a critical role in the vasculogenic mimicry (VM) of tumors. Therefore, the present study examined the effects of galectin-3 knockdown using lentivirus vectors on VM in EC. Eca109 and EC9706 EC cells were transfected with a lentiviral vector to inhibit galectin-3 expression, or a control vector...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29535383/a-lats-biosensor-screen-identifies-vegfr-as-a-regulator-of-the-hippo-pathway-in-angiogenesis
#17
T Azad, H J Janse van Rensburg, E D Lightbody, B Neveu, A Champagne, A Ghaffari, V R Kay, Y Hao, H Shen, B Yeung, B A Croy, K L Guan, F Pouliot, J Zhang, C J B Nicol, X Yang
The Hippo pathway is a central regulator of tissue development and homeostasis, and has been reported to have a role during vascular development. Here we develop a bioluminescence-based biosensor that monitors the activity of the Hippo core component LATS kinase. Using this biosensor and a library of small molecule kinase inhibitors, we perform a screen for kinases modulating LATS activity and identify VEGFR as an upstream regulator of the Hippo pathway. We find that VEGFR activation by VEGF triggers PI3K/MAPK signaling, which subsequently inhibits LATS and activates the Hippo effectors YAP and TAZ...
March 13, 2018: Nature Communications
https://www.readbyqxmd.com/read/29512767/knockdown-of-zeb1-suppressed-the-formation-of-vasculogenic-mimicry-and-epithelial-mesenchymal-transition-in-the-human-breast-cancer-cell-line-mda-mb-231
#18
Weili Liang, Shasha Song, Yintao Xu, Huiying Li, Huantao Liu
Breast cancer is a common malignant tumor in women. It has been suggested that a type of microcirculation pattern that does not rely on host microvascular endothelial cells known as vasculogenic mimicry (VM) may contribute to the poor effect of anti‑angiogenesis treatment on some patients with breast cancer. However, the formation and regulatory mechanism of VM in breast cancer are unclear and still require further investigation. The present study examined whether decreasing the expression of zinc finger E‑box binding homeobox (ZEB1) using siRNA can inhibit the formation of VM in Triple Negative Breast Cancer (TNBC), and its specific function and molecular mechanism...
May 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29499931/long-non-coding-rna-linc00339-stimulates-glioma-vasculogenic-mimicry-formation-by-regulating-the-mir-539-5p-twist1-mmps-axis
#19
Junqing Guo, Heng Cai, Xiaobai Liu, Jian Zheng, Yunhui Liu, Wei Gong, Jiajia Chen, Zhuo Xi, Yixue Xue
Glioma is recognized as a highly angiogenic malignant brain tumor. Vasculogenic mimicry (VM) greatly restricts the therapeutic effect of anti-angiogenic tumor therapy for glioma patients. However, the molecular mechanisms of VM formation in glioma remain unclear. Here, we demonstrated that LINC00339 was upregulated in glioma tissue as well as in glioma cell lines. The expression of LINC00339 in glioma tissues was positively correlated with glioma VM formation. Knockdown of LINC00339 inhibited glioma cell proliferation, migration, invasion, and tube formation, meanwhile downregulating the expression of VM-related molecular MMP-2 and MMP-14...
March 2, 2018: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/29452694/chitinase-3-like-1-chi3l1-promotes-vasculogenic-mimicry-formation-in-cervical-cancer
#20
Nipaporn Ngernyuang, Rong Shao, Komsun Suwannarurk, Temduang Limpaiboon
Vasculogenic mimicry (VM) is an alternative microvascular system which tumour cells orchestrate, independent of endothelial cell-mediated angiogenesis. VM develops tumour vascular networks that correlate with tumour growth, metastasis, and short survival time of patients with a number of cancers. However, little is known regarding VM in the vascularisation of cervical cancer. Chitinase 3 like 1 (CHI3L1) has been previously reported to display the ability to induce angiogenesis in cervical cancer. Here, we explored a pathological role of CHI3L1 in tumour cell-mediated vascularisation...
April 2018: Pathology
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