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Vasculogenic mimicry

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https://www.readbyqxmd.com/read/28938545/overexpression-of-leptin-receptor-in-human-glioblastoma-correlation-with-vasculogenic-mimicry-and-poor-prognosis
#1
Guosheng Han, Yanan Li, Yiqun Cao, Zhijian Yue, Yuhui Zhang, Laixing Wang, Jianmin Liu
Vasculogenic mimicry (VM) was an important tumor blood supply to complement the endothelial cell-dependent angiogenesis, while leptin and receptor (ObR) involved in angiogenesis in glioblastoma has been reported on previous study, but the relationship between ObR expression and VM formation in human glioblastoma tissues, as well as their prognostic significance still remains unclear. In our study, we found that VM recognized by CD31-/PAS+ immunohistochemical staining in glioblastoma tissues showed a positive correlation with leptin expression (r = 0...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28932123/downregulation-of-deptor-inhibits-the-proliferation-migration-and-survival-of-osteosarcoma-through-pi3k-akt-mtor-pathway
#2
Binwu Hu, Xiao Lv, Feng Gao, Songfeng Chen, Shangyu Wang, Xiangcheng Qing, Jianxiang Liu, Baichuan Wang, Zengwu Shao
Accumulating evidence reveals that DEP-domain containing mTOR-interacting protein (DEPTOR) plays pivotal roles in the pathogenesis and progression of many tumors. However, the expression level of DEPTOR and its function in the tumorigenesis of osteosarcoma (OS) remain unknown. In this study, we conducted quantitative real-time polymerase chain reaction, Western blot, and immunohistochemistry to detect DEPTOR expression level in human OS tissues and cell lines. To assess DEPTOR function, DEPTOR siRNA was designed and transfected into OS cells, which were then used in a series of in vitro assays...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28915600/tumor-vasculogenic-mimicry-formation-as-an-unfavorable-prognostic-indicator-in-patients-with-breast-cancer
#3
Yanwei Shen, Jianfeng Quan, Mengying Wang, Shuting Li, Jiao Yang, Meng Lv, Zheling Chen, Lingxiao Zhang, Xiaoai Zhao, Jin Yang
Vasculogenic mimicry (VM), a newly defined pattern of tumor blood perfusion, describes the functional plasticity of aggressive tumor cells forming de novo vascular networks and is associated with the cancer progression and metastasis. However, the VM-positive rate and the impact of VM status on breast cancer patients' clinicopathological parameters and prognosis remain unclear. Thus, we performed a meta-analysis by incorporating all available evidence to clarify these issues. Eight studies that involved 1,238 breast cancer patients were eligible for inclusion in our study...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28910167/expression-of-antimicrobial-peptides-by-uveal-and-cutaneous-melanoma-cells-and-investigation-of-their-role-in-tumor-cell-migration-and-vasculogenic-mimicry
#4
Joseph C Manarang, Deborah C Otteson, Alison M McDermott
AIMS: Antimicrobial peptides (AMPs) have been implicated in the pathogenesis of several cancers, although there is also evidence suggesting potential for novel, AMP-based antitumor therapies. Discerning potential roles of AMPs in tumor pathogenesis may provide valuable insight into the mechanisms of novel AMP-based antitumor therapy. METHODS: mRNA expression of the AMPs α defensin (HNP-1); cathelicidin (LL-37); and β defensins (hBD-1, hBD-2, hBD-3, hBD-4) in human uveal and cutaneous melanoma cell lines, primary human uveal melanocytes, and primary human uveal melanoma cells was determined by reverse transcriptase polymerase chain reaction...
September 14, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28868282/growth-of-uveal-melanoma-following-intravitreal-bevacizumab
#5
Jasmine H Francis, Jonathan Kim, Amy Lin, Robert Folberg, Saipriya Iyer, David H Abramson
PURPOSE: Typically treatment of large melanomas (by Collaborative Ocular Melanoma Study criteria) is restricted to enucleation, due to size constraints for plaque brachytherapy. Because primary and metastatic uveal melanoma cells are inhibited by bevacizumab (an anti-vascular endothelial growth factor), this prospective study evaluated the impact of intravitreal bevacizumab on large uveal melanomas that were destined for enucleation. Size reduction by bevacizumab would potentially salvage these eyes by making them eligible for treatment with plaque brachytherapy...
July 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/28860821/osteopontin-and-vasculogenic-mimicry-formation-are-associated-with-response-to-neoadjuvant-chemotherapy-in-advanced-breast-cancer
#6
Ming Gu, Xinyu Zheng
INTRODUCTION: Osteopontin (OPN), a multifunctional phosphoprotein, has been implicated in a series of important physiologic and pathophysiologic processes. In breast cancer, OPN functionally contributes to the tumorigenicity of spheroid-forming cells. It also plays a critical role in enhancing the proliferation, tumorigenicity, and ability to display vasculogenic mimicry (VM) of spheroid-forming cells in breast cancer. However, the role of OPN in breast cancer is not clear. PATIENTS AND METHODS: This study investigated OPN expression and VM in breast cancer patients before neoadjuvant chemotherapy (NACT)...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28842255/cyclin-dependent-kinase-5-controls-vasculogenic-mimicry-formation-in-non-small-cell-lung-cancer-via-the-fak-akt-signaling-pathway
#7
Xiaoshu Zhou, Runxia Gu, Xiaoming Han, Gang Wu, Junli Liu
Vasculogenic mimicry (VM), an endothelial-independent tumor vascularization phenomenon representing functional tumor plasticity, might be the culprit behind the poor clinical outcome in classic antiangiogenesis treatment. However, the mechanism underlying VM needs to be elucidated. Cyclin-dependent kinase 5 (CDK5) has been recognized as a key factor in regulating migration and neuronal plasticity. Recently, CDK5 was associated with tumor migration and invasion and its expression levels correlated with poor clinical prognosis, indicating its important role in tumor cell plasticity...
August 24, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28812437/autophagy-induced-kdr-vegfr-2-activation-promotes-the-formation-of-vasculogenic-mimicry-by-glioma-stem-cells
#8
Hai-Bo Wu, Shuai Yang, Hai-Yan Weng, Qian Chen, Xi-Long Zhao, Wen-Juan Fu, Qin Niu, Yi-Fang Ping, Ji Ming Wang, Xia Zhang, Xiao-Hong Yao, Xiu-Wu Bian
Antiangiogenesis with bevacizumab, an antibody against vascular endothelial growth factor (VEGF), has been used for devascularization to limit the growth of malignant glioma. However, the benefits are transient due to elusive mechanisms underlying resistance to the antiangiogenic therapy. Glioma stem cells (GSCs) are capable of forming vasculogenic mimicry (VM), an alternative microvascular circulation independent of VEGF-driven angiogenesis. Herein, we report that the formation of VM was promoted by bevacizumab-induced macroautophagy/autophagy in GSCs, which was associated with tumor resistance to antiangiogenic therapy...
August 16, 2017: Autophagy
https://www.readbyqxmd.com/read/28766880/mmp-2-and-mmp-13-affect-vasculogenic-mimicry-formation-in-large-cell-lung-cancer
#9
Yanlei Li, Baocun Sun, Xiulan Zhao, Xudong Wang, Danfang Zhang, Qiang Gu, Tieju Liu
Matrix metalloproteinases (MMPs) have critical functions in tumour vasculogenic mimicry (VM). This study explored the mechanisms underlying MMP-13 and MMP-2 regulation of tumour VM formation in large cell lung cancer (LCLC). In our study, laminin5 (Ln-5) fragments cleaved by MMP-2 promoted tubular structure formation by the LCLC cell lines H460 and H661 in three-dimensional (3D) cultures. Transient up-regulation of MMP-13 or treatment with recombinant MMP-13 protein abrogated tubular structure formation of H460 cells in 3D culture...
August 2, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28765613/structural-and-functional-identification-of-vasculogenic-mimicry-in-vitro
#10
Dusan Racordon, Andrés Valdivia, Gabriel Mingo, Rafaela Erices, Raúl Aravena, Felice Santoro, Maria Loreto Bravo, Carolina Ramirez, Pamela Gonzalez, Alejandra Sandoval, Alfonso González, Claudio Retamal, Marcelo J Kogan, Sumie Kato, Mauricio A Cuello, German Osorio, Francisco Nualart, Pedro Alvares, Araceli Gago-Arias, Daniella Fabri, Ignacio Espinoza, Beatriz Sanchez, Alejandro H Corvalán, Mauricio P Pinto, Gareth I Owen
Vasculogenic mimicry (VM) describes a process by which cancer cells establish an alternative perfusion pathway in an endothelial cell-free manner. Despite its strong correlation with reduced patient survival, controversy still surrounds the existence of an in vitro model of VM. Furthermore, many studies that claim to demonstrate VM fail to provide solid evidence of true hollow channels, raising concerns as to whether actual VM is actually being examined. Herein, we provide a standardized in vitro assay that recreates the formation of functional hollow channels using ovarian cancer cell lines, cancer spheres and primary cultures derived from ovarian cancer ascites...
August 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28765537/prdx2-in-myocyte-hypertrophy-and-survival-is-mediated-by-tlr4-in-acute-infarcted-myocardium
#11
Xian Jin, Chengjun Chen, Dandan Li, Qian Su, Yanwen Hang, Peng Zhang, Wei Hu
Peroxiredoxin 2 (PRDX2) is an antioxidant and molecular chaperone that can be secreted from tumor cells. But the role of PRDX2 in acute myocardial infarction (AMI) is not clear. In the current study, we demonstrate the role of PRDX2 from clinical trials, H9c2 cells and in a mouse model. ELISA analysis shows that serum concentrations of VEGF and inflammatory factor IL-1β, TNF-α and IL-6 were increased in AMI patients compared to a control group. The expression of PRDX2 was also upregulated. In vivo experiments show that the expression of PRDX2 inhibits hypoxia-induced oxidative stress injury to H9c2 cells...
August 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28743828/tm4sf5-promotes-metastatic-behavior-of-cells-in-3d-extracellular-matrix-gels-by-reducing-dependency-on-environmental-cues
#12
Dae-Geun Song, Gyu-Ho Lee, Seo Hee Nam, Jin-Gyu Cheong, Doyoung Jeong, Seo-Jin Lee, Cheol-Ho Pan, Jae Woo Jung, Hye-Jin Kim, Jihye Ryu, Ji Eon Kim, Somi Kim, Chang Yun Cho, Min-Kyung Kang, Kyung-Min Lee, Jung Weon Lee
Transmembrane 4 L six family member 5 (TM4SF5) is highly expressed in hepatocellular carcinoma tissues and enhances migration in two-dimensional environments. Here, we investigated how TM4SF5 is involved in diverse pro-metastatic phenotypes in in vivo-like three-dimensional (3D) extracellular matrix gels. TM4SF5-positive cells aggressively formed invasive foci in 3D Matrigel, depending on TM4SF5-mediated signaling activity, cytoskeletal organization, and matrix metallopeptidase (MMP) 2-mediated extracellular remodeling, whereas TM4SF5-null cells did not...
May 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28726209/characteristics-of-mel-ibr-melanoma-line-subclone-after-treatment-with-chicken-embryo-extract
#13
N M Suraeva, L F Morozova, O O Ryabaya, Yu A Khochenkova, A V Samoilov, O S Burova, N V Golubtsova, A E Barmashov, M A Baryshnikova
We continue analysis of the phenotype of human melanoma cell Mel Ibr subclone obtained previously by treatment of the parental cell line by chicken embryo extract. The present study is focused on detection of markers of epithelial-mesenchymal transition that determine enhanced metastatic and invasive potential of malignant tumors of various locations. Analysis of the expression of E-cadherin and vimentin genes in the subclone and parental cells detected activation of epithelial-mesenchymal transition in the subclone...
June 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28700345/platelet-derived-growth-factor-c-promotes-human-melanoma-aggressiveness-through-activation-of-neuropilin-1
#14
Federica Ruffini, Lauretta Levati, Grazia Graziani, Simona Caporali, Maria Grazia Atzori, Stefania D'Atri, Pedro M Lacal
Despite recent progress in advanced melanoma therapy, identification of signalling pathways involved in melanoma switch from proliferative to invasive states is still crucial to uncover new therapeutic targets for improving the outcome of metastatic disease. Neuropilin-1 (NRP-1), a co-receptor for vascular endothelial growth factor-A (VEGF-A) tyrosine kinase receptors (VEGFRs), has been suggested to play a relevant role in melanoma progression. NRP-1 can be activated by VEGF-A also in the absence of VEGFRs, triggering specific signal transduction pathways (e...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28699701/rictor-regulates-the-vasculogenic-mimicry-of-melanoma-via-the-akt-mmp-2-9-pathway
#15
Xingmei Liang, Ran Sun, Xiulan Zhao, Yanhui Zhang, Qiang Gu, Xueyi Dong, Danfang Zhang, Junying Sun, Baocun Sun
Vasculogenic mimicry (VM)-positive melanomas are usually associated with poor prognosis. Rictor, the key component of the rapamycin-insensitive complex of mTOR (mTORC2), is up-regulated in several cancers, especially in melanomas with poor prognosis. The aim of this study was to investigate the role of Rictor in the regulation of VM and the mechanism underlying this possible regulation. VM channels were found in 35 of 81 tested melanoma samples and high Rictor expression correlated with VM structures. Moreover, Kaplan-Meier survival curves indicated that VM structures and high Rictor expression correlated with shorter survival in patients with melanoma...
July 12, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28694103/coe-inhibits-vasculogenic-mimicry-in-hepatocellular-carcinoma-via-suppressing-notch1-signaling
#16
Chen Jue, Zhao Min, Zhang Zhisheng, Cui Lin, Qian Yayun, Wang Xuanyi, Jin Feng, Wang Haibo, Shi Youyang, Hisamitsu Tadashi, Ishikawa Shintaro, Guo Shiyu, Liu Yanqing
ETHNOPHARMACOLOGICAL RELEVANCE: Vasculogenic mimicry (VM) has been suggested to be present in various malignant tumors and associated with tumor nutrition supply and metastasis, leading to poor prognosis of patients. Notch1 has been demonstrated to contribute to VM formation in hepathocellular carcinoma (HCC). Celastrus orbiculatus extract (COE), a mixture of 11 terpenoids isolated from the Chinese Herb Celastrus orbiculatus Vine, has been suggested to be effective in cancer treatment...
July 8, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28685576/egfr-egfrviii-dual-targeting-peptide-mediated-drug-delivery-for-enhanced-glioma-therapy
#17
Jiani Mao, Danni Ran, Cao Xie, Qing Shen, Songli Wang, Weiyue Lu
Tumor-homing peptides have been widely used to mediate active targeted drug delivery. l-AE is a reported targeting peptide demonstrating high binding affinity to epidermal growth factor receptor (EGFR) and mutation variant III (EGFRvIII) overexpressed on neovasculature, vasculogenic mimicry, tumor cells, and tumor stem cells. To improve its proteolytic stability, a d-peptide ligand (termed d-AE, the enantiomer of l-AE) was developed. d-AE was confirmed to bind receptors EGFR and EGFRvIII with targeting capability comparable to l-AE...
July 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28678767/txndc5-is-a-cervical-tumor-susceptibility-gene-that-stimulates-cell-migration-vasculogenic-mimicry-and-angiogenesis-by-down-regulating-serpinf1-and-traf1-expression
#18
Bing Xu, Jian Li, Xiaoxin Liu, Chang Li, Xiaotian Chang
TXNDC5 (thioredoxin domain-containing protein 5) catalyzes disulfide bond formation, isomerization and reduction. Studies have reported that TXNDC5 expression is increased in some tumor tissues and that its increased expression can predict a poor prognosis. However, the tumorigenic mechanism has not been well characterized. In this study, we detected a significant association between the rs408014 and rs7771314 SNPs at the TXNDC5 locus and cervical carcinoma using the Taqman genotyping method. We also detected a significantly increased expression of TXNDC5 in cervical tumor tissues using immunohistochemistry and Western blot analysis...
June 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28666273/macrophage-migration-inhibitory-factor-promotes-vasculogenic-mimicry-formation-induced-by-hypoxia-via-cxcr4-akt-emt-pathway-in-human-glioblastoma-cells
#19
Xing Guo, Shugang Xu, Xiao Gao, Jian Wang, Hao Xue, Zihang Chen, Jinsen Zhang, Xiaofan Guo, Mingyu Qian, Wei Qiu, Gang Li
Macrophage migration inhibitory factor (MIF) is over-expressed and secreted in various cancer cells in particular in response to hypoxia. Recent studies have shown that, under hypoxic conditions, glioblastoma (GBM) cells display the ability to drive blood-perfused vasculogenic mimicry (VM). The aim of this study was to investigate the underlying mechanism of MIF in the regulation of hypoxia-induced VM in GBM cells. By analyzing clinical specimens, we observed the co-localization of MIF, C-X-C motif chemokine receptor 4 (CXCR4) and VM in hypoxic regions of gliomas...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28655612/luteolin-suppresses-angiogenesis-and-vasculogenic-mimicry-formation-through-inhibiting-notch1-vegf-signaling-in-gastric-cancer
#20
Mingde Zang, Lei Hu, Baogui Zhang, Zhenglun Zhu, Jianfang Li, Zhenggang Zhu, Min Yan, Bingya Liu
Gastric cancer is a great threat to the health of the people worldwide and lacks effective therapeutic regimens. Luteolin is one of Chinese herbs and presents in many fruits and green plants. In our previous study, we observed that luteolin inhibited cell migration and promoted cell apoptosis in gastric cancer. In the present study, luteolin significantly inhibited tube formation of human umbilical vein endothelial cells (HUVECs) through decreasing cell migration and proliferation of HUVECs in a dose-dependent manner...
August 26, 2017: Biochemical and Biophysical Research Communications
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