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https://www.readbyqxmd.com/read/29111702/identification-and-interrogation-of-the-herbicidin-biosynthetic-gene-cluster-first-insight-into-the-biosynthesis-of-a-rare-undecose-nucleoside-antibiotic
#1
Geng-Min Lin, Anthony J Romo, Priscilla H Liem, Zhang Chen, Hung-Wen Liu
Herbicidins are adenosine-based nucleoside antibiotics with an unusual tricyclic undecose core decorated with a (5-hydroxy)tiglyl moiety. Feeding studies are herein reported demonstrating that the tricyclic core is derived from d-glucose and d-ribose, whereas the tiglyl moiety is derived from an intermediate of l-isoleucine catabolism. Identification of the gene cluster for herbicidin A biosynthesis in Streptomyces sp. L-9-10 as well as its verification by heterologous expression in a nonproducing host are described, and the results of in vitro characterization of a carboxyl methyltransferase encoded in the cluster, Her8, are presented...
November 8, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29094159/medical-scribes-in-an-academic-dermatology-practice
#2
Vinod E Nambudiri, Alice J Watson, Elizabeth A Buzney, Thomas S Kupper, Mitchell H Rubenstein, Fei-Shiuann Clarissa Yang
No abstract text is available yet for this article.
November 1, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28984020/single-step-reagentless-laser-scribing-fabrication-of-electrochemical-paper-based-analytical-devices
#3
William R de Araujo, Carolina M R Frasson, Wilson A Ameku, José R Silva, Lúcio Angnes, Thiago R L C Paixão
A single-step laser scribing process is used to pattern nanostructured electrodes on paper-based devices. The facile and low-cost technique eliminates the need for chemical reagents or controlled conditions. This process involves the use of a CO2 laser to pyrolyze the surface of the paperboard, producing a conductive porous non-graphitizing carbon material composed of graphene sheets and composites with aluminosilicate nanoparticles. The new electrode material was extensively characterized, and it exhibits high conductivity and an enhanced active/geometric area ratio; it is thus well-suited for electrochemical purposes...
October 5, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28971848/emergency-consultants-value-medical-scribes-and-most-prefer-to-work-with-them-a-few-would-rather-not-a-qualitative-australian-study
#4
Timothy Luke Cowan, William A Dunlop, Michael Ben-Meir, Margaret Staples, Ainsley Treadwell, Eliza Gardner-Brunton, Katherine Justice Walker
OBJECTIVE: The utilisation of medical scribes in the USA has enabled productivity gains for emergency consultants, though their personal experiences have not been widely documented. We aimed to evaluate the consultant experience of working with scribes in an Australian ED. METHODS: Emergency consultants working with scribes and those who declined to work with scribes were invited to participate in individual interviews (structured and semistructured questions) about scribes, scribe work and the scribe program in October 2016...
September 29, 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28956888/the-9-item-physician-documentation-quality-instrument-pdqi-9-score-is-not-useful-in-evaluating-emr-scribe-note-quality-in-emergency-medicine
#5
Katherine J Walker, Andrew Wang, William Dunlop, Hamish Rodda, Michael Ben-Meir, Margaret Staples
BACKGROUND: Scribes are assisting Emergency Physicians by writing their electronic clinical notes at the bedside during consultations. They increase physician productivity and improve their working conditions. The quality of Emergency scribe notes is unevaluated and important to determine. OBJECTIVE: The primary objective of the study was to determine if the quality of Emergency Department scribe notes was equivalent to physician only notes, using the Physician Documentation Quality Instrument, Nine-item tool (PDQI-9)...
September 26, 2017: Applied Clinical Informatics
https://www.readbyqxmd.com/read/28931497/use-of-simulation-based-on-an-electronic-health-records-environment-to-evaluate-the-structure-and-accuracy-of-notes-generated-by-medical-scribes-proof-of-concept-study
#6
Robert Pranaat, Vishnu Mohan, Megan O'Reilly, Maxwell Hirsh, Karess McGrath, Gretchen Scholl, Deborah Woodcock, Jeffrey A Gold
BACKGROUND: The increasing adoption of electronic health records (EHRs) has been associated with a number of unintended negative consequences with provider efficiency and job satisfaction. To address this, there has been a dramatic increase in the use of medical scribes to perform many of the required EHR functions. Despite this rapid growth, little has been published on the training or assessment tools to appraise the safety and efficacy of scribe-related EHR activities. Given the number of reports documenting that other professional groups suffer from a number of performance errors in EHR interface and data gathering, scribes likely face similar challenges...
September 20, 2017: JMIR Medical Informatics
https://www.readbyqxmd.com/read/28893812/impact-of-scribes-on-physician-satisfaction-patient-satisfaction-and-charting-efficiency-a-randomized-controlled-trial
#7
Risha Gidwani, Cathina Nguyen, Alexis Kofoed, Catherine Carragee, Tracy Rydel, Ian Nelligan, Amelia Sattler, Megan Mahoney, Steven Lin
PURPOSE: Scribes are increasingly being used in clinical practice despite a lack of high-quality evidence regarding their effects. Our objective was to evaluate the effect of medical scribes on physician satisfaction, patient satisfaction, and charting efficiency. METHODS: We conducted a randomized controlled trial in which physicians in an academic family medicine clinic were randomized to 1 week with a scribe then 1 week without a scribe for the course of 1 year...
September 2017: Annals of Family Medicine
https://www.readbyqxmd.com/read/28796453/sociology-as-a-love-story-confessions-of-a-movement-scribe
#8
Judith Taylor
No abstract text is available yet for this article.
August 2017: Canadian Review of Sociology, Revue Canadienne de Sociologie
https://www.readbyqxmd.com/read/28737226/laser-induced-graphene-formation-on-wood
#9
Ruquan Ye, Yieu Chyan, Jibo Zhang, Yilun Li, Xiao Han, Carter Kittrell, James M Tour
Wood as a renewable naturally occurring resource has been the focus of much research and commercial interests in applications ranging from building construction to chemicals production. Here, a facile approach is reported to transform wood into hierarchical porous graphene using CO2 laser scribing. Studies reveal that the crosslinked lignocellulose structure inherent in wood with higher lignin content is more favorable for the generation of high-quality graphene than wood with lower lignin content. Because of its high electrical conductivity (≈10 Ω per square), graphene patterned on wood surfaces can be readily fabricated into various high-performance devices, such as hydrogen evolution and oxygen evolution electrodes for overall water splitting with high reaction rates at low overpotentials, and supercapacitors for energy storage with high capacitance...
July 24, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28723173/laser-scribed-graphene-electrodes-for-aptamer-based-biosensing
#10
Christoph Fenzl, Pranati Nayak, Thomas Hirsch, Otto S Wolfbeis, Husam N Alshareef, Antje J Baeumner
Graphene as a transducer material has produced some of the best-performing sensing approaches to date opening the door toward integrated miniaturized all-carbon point-of-care devices. Addressing this opportunity, laser-scribed graphene (LSG) electrodes are demonstrated here as highly sensitive and reliable biosensor transducers in blood serum analysis. These flexible electrodes with large electrochemical surface areas were fabricated using a direct-write laser process on polyimide foils. A universal immobilization approach is established by anchoring 1-pyrenebutyric acid to the graphene and subsequently covalently attaching an aptamer against the coagulation factor thrombin as an exemplary bioreceptor to the carboxyl groups...
May 26, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28712608/a-custom-developed-emergency-department-provider-electronic-documentation-system-reduces-operational-efficiency
#11
Joshua Feblowitz, Sukhjit S Takhar, Michael J Ward, Ryan Ribeira, Adam B Landman
STUDY OBJECTIVE: Electronic health record implementation can improve care, but may also adversely affect emergency department (ED) efficiency. We examine how a custom, ED provider, electronic documentation system (eDoc), which replaced paper documentation, affects operational performance. METHODS: We analyzed retrospective operational data for 1-year periods before and after eDoc implementation in a single ED. We computed daily operational statistics, reflecting 60,870 pre- and 59,337 postimplementation patient encounters...
November 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28705266/a-new-method-for-blood-nt-probnp-determination-based-on-a-near-infrared-point-of-care-testing-device-with-high-sensitivity-and-wide-scope
#12
Xiao Guang Zhang, Yao Gen Shu, Ju Gao, Xuan Wang, Li Peng Liu, Meng Wang, Yu Xi Cao, Yi Zeng
OBJECTIVE: To develop a rapid, highly sensitive, and quantitative method for the detection of NT-proBNP levels based on a near-infrared point-of-care diagnostic (POCT) device with wide scope. METHODS: The lateral flow assay (LFA) strip of NT-proBNP was first prepared to achieve rapid detection. Then, the antibody pairs for NT-proBNP were screened and labeled with the near-infrared fluorescent dye Dylight-800. The capture antibody was fixed on a nitrocellulose membrane by a scribing device...
June 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28681974/supramolecular-gel-electrophoresis-of-large-dna-fragments
#13
Shohei Tazawa, Kazuhiro Kobayashi, Takanori Oyoshi, Masamichi Yamanaka
Pulsed-field gel electrophoresis is a frequent technique used to separate exceptionally large DNA fragments. In a typical continuous field electrophoresis, it is challenging to separate DNA fragments larger than 20 kbp because they migrate at a comparable rate. To overcome this challenge, it is necessary to develop a novel matrix for the electrophoresis. Here, we describe the electrophoresis of large DNA fragments up to 166 kbp using a supramolecular gel matrix and a typical continuous field electrophoresis system...
October 2017: Electrophoresis
https://www.readbyqxmd.com/read/28675656/direct-creation-of-highly-conductive-laser-induced-graphene-nanocomposites-from-polymer-blends
#14
Alireza Zehtab Yazdi, Ivonne Otero Navas, Ahmed Abouelmagd, Uttandaraman Sundararaj
The current state-of-the-art mixing strategies of nanoparticles with insulating polymeric components have only partially utilized the unique electrical conductivity of graphene in nanocomposite systems. Herein, this paper reports a nonmixing method of direct creation of polymer/graphene nanocomposites from polymer blends via laser irradiation. Polycarbonate-laser-induced graphene (PC-LIG) nanocomposite is produced from a PC/polyetherimide (PC/PEI) blend after exposure to commercially available laser scribing with a power of ≈6 W and a speed of ≈2 cm s(-1) ...
July 4, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28647720/thinker-soldier-scribe-cross-sectional-study-of-researchers-roles-and-author-order-in-the-annals-of-internal-medicine
#15
Thomas V Perneger, Antoine Poncet, Marc Carpentier, Thomas Agoritsas, Christophe Combescure, Angèle Gayet-Ageron
OBJECTIVE: How researchers' contributions relate to author order on the byline remains unclear. We sought to identify researchers' contributions associated with author order, and to explore the existence of author profiles. DESIGN: Observational study. SETTING: Published record. PARTICIPANTS: 1139 authors of 119 research articles published in 2015 in the Annals of Internal Medicine. PRIMARY OUTCOMES: Presence or absence of 10 contributions, reported by each author, published in the journal...
June 24, 2017: BMJ Open
https://www.readbyqxmd.com/read/28641236/analytical-evidences-of-the-use-of-iron-gall-ink-as-a-pigment-on-miniature-paintings
#16
Maurizio Aceto, Elisa Calà
Iron-gall ink (IGI) has been used by scribes for writing since at least the 4th century CE. Another typical use of this ink was for drawing: many Old Masters created beautiful sketches in brown-black hues. Despite its widespread use to draw lines, it seems like IGI was hardly used for painting as well. In fact, the number of identification on manuscripts is very low at present. This could be partially due to a lack of reliable diagnostic information. In this work we tried to better define the possibility of identifying IGI as a pigment on illuminate manuscripts, evaluating the pros and cons of three different techniques: UV-visible diffuse reflectance spectrophotometry with optic fibres (FORS), Raman spectroscopy and XRF spectrometry...
June 15, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28619551/evidence-based-recommendations-for-the-management-of-acne-fulminans-and-its-variants
#17
REVIEW
Tanya Greywal, Andrea L Zaenglein, Hilary E Baldwin, Neal Bhatia, Karen A Chernoff, James Q Del Rosso, Lawrence F Eichenfield, Marc H Levin, James J Leyden, Diane M Thiboutot, Guy F Webster, Sheila Fallon Friedlander
BACKGROUND: Acne fulminans (AF) is a severe variant of inflammatory acne. It typically manifests as an explosive worsening and ulceration of skin lesions, and can be associated with systemic symptoms. However, there is a paucity of evidence-based information and no clear guidelines concerning the classification and treatment of AF. OBJECTIVE: To better define the spectrum of AF and its variants, devise optimal therapeutic approaches, and identify areas of future research...
July 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28589691/medical-scribes-have-no-impact-on-the-patient-experience-of-an-emergency-department
#18
William Dunlop, Lachlan Hegarty, Margaret Staples, Michele Levinson, Michael Ben-Meir, Katherine Walker
OBJECTIVE: We aimed to evaluate patient perceptions of medical scribes in the ED and to test for scribe impacts on ED Net Promoter Scores, Press Ganey Surveys and other patient-centred topics. METHODS: Exploratory semi-structured interviews were conducted in the ED during wait times after scribed consultations. Interview results were used to derive topics relating to scribes. Items addressing these topics from validated surveys were combined with items from widely used patient satisfaction questionnaires...
June 6, 2017: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/28548293/local-photocurrent-mapping-and-cell-performance-behaviour-on-a-nanometre-scale-for-monolithically-interconnected-cu-in-ga-se2-solar-cells
#19
M Haggui, B Reinhold, P Andrae, D Greiner, M Schmid, P Fumagalli
The local efficiency of lamellar shaped Cu(In,Ga)Se2 solar cells has been investigated using scanning near-field optical microscopy (SNOM). Topographic and photocurrent measurements have been performed simultaneously with a 100 nm tip aperture. The lamellar shaped solar cell with monolithic interconnects (P scribe) has been investigated on a nanometre scale for the first time at different regions using SNOM. It was found that, the cell region between P1 and P2 significantly contributes to the solar cells overall photocurrent generation...
May 26, 2017: Journal of Microscopy
https://www.readbyqxmd.com/read/28526590/scribes-re-writing-the-story-on-patient-and-provider-experience
#20
Kyle Morawski, Jennifer Childs-Roshak, Alan Weitberg
No abstract text is available yet for this article.
September 2017: Healthcare
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