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Bipolar disorder and circadian rhythms

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https://www.readbyqxmd.com/read/28321642/circadian-rhythm-dysregulation-in-bipolar-spectrum-disorders
#1
REVIEW
Lauren B Alloy, Tommy H Ng, Madison K Titone, Elaine M Boland
PURPOSE OF REVIEW: We review recent evidence for circadian rhythm dysregulation in bipolar spectrum disorders (BSDs). We examine evidence for endogenous abnormalities in the biological clock and disruptions in the external entrainment of circadian rhythms in BSDs. We also address whether circadian dysregulation provides vulnerability to onset of BSD and evidence for a new integration of reward and circadian dysregulation in BSD. RECENT FINDINGS: Relative circadian phase delay (e...
April 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/28264500/geneanalytics-pathway-analysis-and-genetic-overlap-among-autism-spectrum-disorder-bipolar-disorder-and-schizophrenia
#2
Naveen S Khanzada, Merlin G Butler, Ann M Manzardo
Bipolar disorder (BPD) and schizophrenia (SCH) show similar neuropsychiatric behavioral disturbances, including impaired social interaction and communication, seen in autism spectrum disorder (ASD) with multiple overlapping genetic and environmental influences implicated in risk and course of illness. GeneAnalytics software was used for pathway analysis and genetic profiling to characterize common susceptibility genes obtained from published lists for ASD (792 genes), BPD (290 genes) and SCH (560 genes). Rank scores were derived from the number and nature of overlapping genes, gene-disease association, tissue specificity and gene functions subdivided into categories (e...
February 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28173893/sleep-and-circadian-rhythm-disturbance-in-bipolar-disorder
#3
A J Bradley, R Webb-Mitchell, A Hazu, N Slater, B Middleton, P Gallagher, H McAllister-Williams, K N Anderson
BACKGROUND: Subjective reports of insomnia and hypersomnia are common in bipolar disorder (BD). It is unclear to what extent these relate to underlying circadian rhythm disturbance (CRD). In this study we aimed to objectively assess sleep and circadian rhythm in a cohort of patients with BD compared to matched controls. METHOD: Forty-six patients with BD and 42 controls had comprehensive sleep/circadian rhythm assessment with respiratory sleep studies, prolonged accelerometry over 3 weeks, sleep questionnaires and diaries, melatonin levels, alongside mood, psychosocial functioning and quality of life (QoL) questionnaires...
February 8, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28117839/the-genetic-overlap-between-mood-disorders-and-cardiometabolic-diseases-a-systematic-review-of-genome-wide-and-candidate-gene-studies
#4
REVIEW
A T Amare, K O Schubert, M Klingler-Hoffmann, S Cohen-Woods, B T Baune
Meta-analyses of genome-wide association studies (meta-GWASs) and candidate gene studies have identified genetic variants associated with cardiovascular diseases, metabolic diseases and mood disorders. Although previous efforts were successful for individual disease conditions (single disease), limited information exists on shared genetic risk between these disorders. This article presents a detailed review and analysis of cardiometabolic diseases risk (CMD-R) genes that are also associated with mood disorders...
January 24, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28116759/improvement-of-a-patient-s-circadian-rhythm-sleep-disorders-by-aripiprazole-was-associated-with-stabilization-of-his-bipolar-illness
#5
Tetsuo Tashiro
Splitting of the behavioural activity phase has been found in nocturnal rodents with suprachiasmatic nucleus (SCN) coupling disorder. A similar phenomenon was observed in the sleep phase in the diurnal human discussed here, suggesting that there are so-called evening and morning oscillators in the SCN of humans. The present case suffered from bipolar disorder refractory to various treatments, and various circadian rhythm sleep disorders, such as delayed sleep phase, polyphasic sleep, separation of the sleep bout resembling splitting and circabidian rhythm (48 h), were found during prolonged depressive episodes with hypersomnia...
January 24, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28115741/bipolar-mood-cycles-and-lunar-tidal-cycles
#6
T A Wehr
In 17 patients with rapid cycling bipolar disorder, time-series analyses detected synchronies between mood cycles and three lunar cycles that modulate the amplitude of the moon's semi-diurnal gravimetric tides: the 14.8-day spring-neap cycle, the 13.7-day declination cycle and the 206-day cycle of perigee-syzygies ('supermoons'). The analyses also revealed shifts among 1:2, 1:3, 2:3 and other modes of coupling of mood cycles to the two bi-weekly lunar cycles. These shifts appear to be responses to the conflicting demands of the mood cycles' being entrained simultaneously to two different bi-weekly lunar cycles with slightly different periods...
January 24, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28060532/critical-slowing-down-as-an-early-warning-of-transitions-in-episodes-of-bipolar-disorder-a-simulation-study-based-on-a-computational-model-of-circadian-activity-rhythms
#7
Atiyeh Bayani, Fatemeh Hadaeghi, Sajad Jafari, Greg Murray
Bipolar disorder is characterized by repeated episodes of mania and depression, and can be understood as pathological complex system behaviour involving cognitive, affective and psychomotor disturbance. Accurate prediction of episode transitions in the long-term pattern of mood changes in bipolar disorder could improve the management of the disorder by providing an objective early warning of relapse. In particular, circadian activity changes measured via actigraphy may contain clinically relevant signals of imminent systemic dysregulation...
2017: Chronobiology International
https://www.readbyqxmd.com/read/27996307/clock-genes-associate-with-white-matter-integrity-in-depressed-bipolar-patients
#8
Irene Bollettini, Elisa Maria Teresa Melloni, Veronica Aggio, Sara Poletti, Cristina Lorenzi, Adele Pirovano, Benedetta Vai, Sara Dallaspezia, Cristina Colombo, Francesco Benedetti
Human genetic studies have implicated specific genes that constitute the molecular clock in the manifestation of bipolar disorder (BD). Among the clock genes involved in the control system of circadian rhythms, CLOCK 3111 T/C and Period3 (PER3) influence core psychopathological features of mood disorders, such as patterns of sleep, rest, and activity, diurnal preference, cognitive performances after sleep loss, age at the onset of the illness, and response to antidepressant treatment. Furthermore, several studies pointed out that bipolar symptomatology is associated with dysfunctions in white matter (WM) integrity, suggesting these structural alterations as a possible biomarker of the disorder...
2017: Chronobiology International
https://www.readbyqxmd.com/read/27857964/women-with-postpartum-weight-retention-have-delayed-wake-times-and-decreased-sleep-efficiency-during-the-perinatal-period-a-brief-report
#9
K M Sharkey, G M Boni, J A Quattrucci, S Blatch, S N Carr
OBJECTIVE: This study assessed sleep and circadian rhythms across the perinatal period in new mothers with and without postpartum weight retention (PPWR). METHODS: Weight was measured at 2 and 16 weeks postpartum in 21 women with previous major depression or bipolar disorder (mean age 29.5±4.7 years) who self-reported pre-pregnancy weight during third trimester. Wrist actigraphy was acquired at 33 weeks gestation and postpartum weeks 2, 6, and 16. Circadian phase was measured at 33 weeks gestation and 6 weeks postpartum...
September 2016: Sleep Health
https://www.readbyqxmd.com/read/27836181/circadian-preferences-oxidative-stress-and-inflammatory-cytokines-in-bipolar-disorder-a-community-study
#10
Thaise Campos Mondin, Taiane de Azevedo Cardoso, Fernanda Pedrotti Moreira, Carolina Wiener, Jean Pierre Oses, Luciano Dias de Mattos Souza, Karen Jansen, Pedro Vieira da Silva Magalhães, Flávio Kapczinski, Ricardo Azevedo da Silva
OBJECTIVE: To assess circadian preference among a community sample of people with bipolar disorder, major depression and without any mood disorders. Secondly, we investigated the association of circadian preference with cytokines interleukin-6 (IL-6), interleukin-10 (IL-10) and, tumor necrosis factor alpha (TNF-α) and oxidative stress assessed by thiobarbituric acid reactive substances (TBARS), uric acid and Protein Carbonyl Content (PCC). METHOD: A cross-sectional study nested in a population-based sample...
December 15, 2016: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/27835725/bright-light-therapy-as-augmentation-of-pharmacotherapy-for-treatment-of-depression-a-systematic-review-and-meta-analysis
#11
REVIEW
Thomas M Penders, Cornel N Stanciu, Alexander M Schoemann, Philip T Ninan, Richard Bloch, Sy A Saeed
Background: Bright light therapy has demonstrated efficacy and is an accepted treatment for seasonal depression. It has been suggested that bright light therapy may have efficacy in nonseasonal depressions. Also, there is evidence that bright light therapy may improve responsiveness to antidepressant pharmacotherapy. Data Sources: We searched PubMed/MEDLINE, PsycINFO, PsycARTICLES, CINAHL, EMBASE, Scopus, and Academic OneFile for English-language literature published between January 1998 and April 2016, using the keywords bright light therapy AND major depression, bright light therapy AND depress*, bright light therapy AND bipolar depression, bright light therapy AND affective disorders, circadian rhythm AND major depression, circadian rhythm AND depress*, and circadian rhythm AND affective disorder...
October 20, 2016: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/27812851/pineal-volume-and-evening-melatonin-in-young-people-with-affective-disorders
#12
Joanne S Carpenter, Amy C Abelmann, Sean N Hatton, Rébecca Robillard, Daniel F Hermens, Maxwell R Bennett, Jim Lagopoulos, Ian B Hickie
Affective disorders in young people have been associated with disruptions in circadian rhythms, including abnormalities in secretion of the pineal hormone melatonin. Previous research reports relationships between pineal gland volumes, melatonin secretion, and sleep-wake cycles, but the relationship between these factors has not been explored in affective disorders. This study aimed to characterize these factors and explore associations with mood symptoms and functioning in a sample of young people with affective disorders...
November 3, 2016: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/27739341/is-the-molecular-clock-ticking-differently-in-bipolar-disorder-methylation-analysis-of-the-clock-gene-arntl
#13
Susanne A Bengesser, Eva Z Reininghaus, Nina Lackner, Armin Birner, Frederike T Fellendorf, Martina Platzer, Nora Kainzbauer, Bernhard Tropper, Christa Hörmanseder, Robert Queissner, Hans-Peter Kapfhammer, Sandra J Wallner-Liebmann, Robert Fuchs, Erwin Petek, Christian Windpassinger, Mario Schnalzenberger, Bernd Reininghaus, Bernd Evert, Andreas Waha
OBJECTIVES: The clock gene ARNTL is associated with the transcription activation of monoamine oxidase A according to previous literature. Thus, we hypothesised that methylation of ARNTL may differ between bipolar disorder (BD) and controls. METHODS: The methylation status of one CpG island covering the first exon of ARNTL (PS2) and one site in the 5' region of ARNTL (cg05733463) were analysed in patients with BD (n = 151) versus controls (n = 66). Methylation analysis was performed by bisulphite-conversion of DNA from fasting blood with the EpiTect Bisulfite Kit, PCR and pyrosequencing...
October 14, 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27716514/mood-disorders-and-biological-rhythms-in-young-adults-a-large-population-based-study
#14
Thaíse Campos Mondin, Taiane de Azevedo Cardoso, Luciano Dias de Mattos Souza, Karen Jansen, Pedro Vieira da Silva Magalhães, Flávio Kapczinski, Ricardo Azevedo da Silva
BACKGROUND: It is known that sleep disturbance has been considered a trait-marker of mood disorders. However, the role of disruptions in biological rhythms, such as eating, activity, and social patterns, needs to be better understood. AIM: To assess the differences in biological rhythms in subjects with bipolar disorder, major depressive disorder, and healthy controls. We also tested the association between disruptions of biological rhythms and circadian preferences...
September 30, 2016: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/27669996/-how-to-characterize-and-treat-sleep-complaints-in-bipolar-disorders
#15
P A Geoffroy, J-A Micoulaud Franchi, R Lopez, I Poirot, A Brion, S Royant-Parola, B Etain
OBJECTIVES: Sleep complaints are very common in bipolar disorders (BD) both during acute phases (manic and depressive episodes) and remission (about 80 % of patients with remitted BD have poor sleep quality). Sleep complaints during remission are of particular importance since they are associated with more mood relapses and worse outcomes. In this context, this review discusses the characterization and treatment of sleep complaints in BD. METHODS: We examined the international scientific literature in June 2016 and performed a literature search with PubMed electronic database using the following headings: "bipolar disorder" and ("sleep" or "insomnia" or "hypersomnia" or "circadian" or "apnoea" or "apnea" or "restless legs")...
September 23, 2016: L'Encéphale
https://www.readbyqxmd.com/read/27661417/sleep-and-circadian-alterations-in-people-at-risk-for-bipolar-disorder-a-systematic-review
#16
Matias Carvalho Aguiar Melo, Raquel Fernandes Garcia, Vicente Bezerra Linhares Neto, Mariana Brasil Sá, Licia Marah Figueredo de Mesquita, Carolina Freitas Cardeal de Araújo, Veralice Meireles Sales de Bruin
BACKGROUND: Sleep and circadian abnormalities have been mostly demonstrated in bipolar patients. However, it is not clear whether these alterations are present in population at high risk for bipolar disorder (BD), indicating a possible risk factor for this condition. OBJECTIVE: This systematic review aims to define current evidence about sleep and rhythm alterations in people at risk for BD and to evaluate sleep and circadian disorders as risk factor for BD. METHODS: The systematic review included all articles about the topic until February 2016...
September 13, 2016: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/27638546/therapeutic-mechanisms-of-lithium-in-bipolar-disorder-recent-advances-and-current-understanding
#17
REVIEW
Gin S Malhi, Tim Outhred
Lithium is the most effective and well established treatment for bipolar disorder, and it has a broad array of effects within cellular pathways. However, the specific processes through which therapeutic effects occur and are maintained in bipolar disorder remain unclear. This paper provides a timely update to an authoritative review of pertinent findings that was published in CNS Drugs in 2013. A literature search was conducted using the Scopus database, and was limited by year (from 2012). There has been a resurgence of interest in lithium therapy mechanisms, perhaps driven by technical advancements in recent years that permit the examination of cellular mechanisms underpinning the effects of lithium-along with the reuptake of lithium in clinical practice...
October 2016: CNS Drugs
https://www.readbyqxmd.com/read/27589593/circadian-rhythms-and-metabolism-from-the-brain-to-the-gut-and-back-again
#18
Matthew R Cribbet, Ryan W Logan, Mathew D Edwards, Erin Hanlon, Clara Bien Peek, Jeremy J Stubblefield, Sridhar Vasudevan, Fiona Ritchey, Ellen Frank
This paper focuses on the relationship between the circadian system and glucose metabolism. Research across the translational spectrum confirms the importance of the circadian system for glucose metabolism and offers promising clues as to when and why these systems go awry. In particular, basic research has started to clarify the molecular and genetic mechanisms through which the circadian system regulates metabolism. The study of human behavior, especially in the context of psychiatric disorders, such as bipolar disorder and major depression, forces us to see how inextricably linked mental health and metabolic health are...
December 2016: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/27545669/molecular-circadian-rhythm-shift-due-to-bright-light-exposure-before-bedtime-is-related-to-subthreshold-bipolarity
#19
Chul-Hyun Cho, Joung-Ho Moon, Ho-Kyoung Yoon, Seung-Gul Kang, Dongho Geum, Gi-Hoon Son, Jong-Min Lim, Leen Kim, Eun-Il Lee, Heon-Jeong Lee
This study examined the link between circadian rhythm changes due to bright light exposure and subthreshold bipolarity. Molecular circadian rhythms, polysomnography, and actigraphy data were studied in 25 young, healthy male subjects, divided into high and low mood disorder questionnaire (MDQ) score groups. During the first 2 days of the study, the subjects were exposed to daily-living light (150 lux) for 4 hours before bedtime. Saliva and buccal cells were collected 5 times a day for 2 consecutive days. During the subsequent 5 days, the subjects were exposed to bright light (1,000 lux), and saliva and buccal cell samples were collected in the same way...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27543154/advanced-circadian-phase-in-mania-and-delayed-circadian-phase-in-mixed-mania-and-depression-returned-to-normal-after-treatment-of-bipolar-disorder
#20
Joung-Ho Moon, Chul-Hyun Cho, Gi Hoon Son, Dongho Geum, Sooyoung Chung, Hyun Kim, Seung-Gul Kang, Young-Min Park, Ho-Kyoung Yoon, Leen Kim, Hee-Jung Jee, Hyonggin An, Daniel F Kripke, Heon-Jeong Lee
Disturbances in circadian rhythms have been suggested as a possible cause of bipolar disorder (BD). Included in this study were 31 mood episodes of 26 BD patients, and 18 controls. Circadian rhythms of BD were evaluated at admission, at 2-week intervals during hospitalization, and at discharge. All participants wore wrist actigraphs during the studies. Saliva and buccal cells were obtained at 8:00, 11:00, 15:00, 19:00, and 23:00 for two consecutive days. Collected saliva and buccal cells were used for analysis of the cortisol and gene circadian rhythm, respectively...
September 2016: EBioMedicine
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