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https://www.readbyqxmd.com/read/28918419/-about-the-association-between-antipsychotic-medication-and-cardiovascular-morbidity-epidemiology-and-possible-background-mechanisms
#1
Gabor Gaszner, Gabor Barna, Peter Dome
The history of antipsychotics began with the discovery of chlorpromazine in the 1950s. Since then this group of medications has become one of the most important element of the armamentarium of psychopharmacology. While initially these pharmacons were used in the treatment of psychotic states (including psychotic mania) in the last approximately 10-15 years new indications - such as treatment of depressive, manic and mixed states and also mood-stabilization in bipolar disorder and also the treatment of major depressive disorder - for several second-generation antipsychotic (SGA) agents have been introduced...
June 2017: Neuropsychopharmacologia Hungarica
https://www.readbyqxmd.com/read/28918417/-clinical-features-of-psychotic-and-non-psychotic-bipolar-patients
#2
Zsuzsanna Belteczki, Zoltan Rihmer, Julia Ujvari
BACKGROUND: Psychotic symptoms are common in the case of manic, depressive and mixed episodes of bipolar disorder; however, the assessment of delusions and hallucinations is frequently improper, thus the patients presenting also psychotic symptoms are treated based on their diagnosis of schizophrenia, schizoaffective disorder or paranoia. Psychotic symptoms in bipolar disorder result less favourable outcomes and course of illness. METHODS: 365 patients (106 males, 259 females) were hospitalized in or institution from January 1st 2015 to September 30th 2016, who were diagnosed with bipolar disorder according to the ICD-10 criteria...
June 2017: Neuropsychopharmacologia Hungarica
https://www.readbyqxmd.com/read/28911851/cortisol-awakening-response-in-patients-with-bipolar-disorder-during-acute-episodes-and-partial-remission-a-pilot-study
#3
Ming-Chyi Huang, Shan-Chi Chuang, Mei-Chih Meg Tseng, Yi-Ling Chien, Shih-Cheng Liao, Hsi-Chung Chen, Po-Hsiu Kuo
This exploratory study examined the cortisol awakening response (CAR) in patients with bipolar disorder (BPD) at acute phases and partial remission of manic or depressive episodes. Saliva samples of twenty-seven BPD inpatients and 25 healthy controls were collected to determine the CAR patterns, and 12 patients were sampled again at partial remission. BPD patients exhibited a non-enhanced CAR pattern. Lower cortisol expression and a blunted CAR distinguished bipolar-depressive patients from the controls. The intra-individual follow-up for both patient groups revealed a non-significant improvement in CAR patterns, indicating a trend of a normalized CAR after partial remission for BPD patients...
September 1, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28904603/mindfulness-based-treatment-for-bipolar-disorder-a-systematic-review-of-the-literature
#4
REVIEW
Sanja Bojic, Rodrigo Becerra
Despite the increasing number of studies examining the effects of mindfulness interventions on symptoms associated with Bipolar Disorder (BD), the effectiveness of this type of interventions remains unclear. The aim of the present systematic review was to (i) critically review all available evidence on Mindfulness Based Cognitive Therapy (MBCT) as a form of intervention for BD; (ii) discuss clinical implications of MBCT in treating patients with BD; and (iii) provide a direction for future research. The review presents findings from 13 studies (N = 429) that fulfilled the following selection criteria: (i) included BD patients; (ii) presented results separately for BD patients and control groups (where a control group was available); (iii) implemented MBCT intervention; (iv) were published in English; (v) were published in a peer reviewed journal; and (vi) reported results for adult participants...
August 2017: Europe's journal of psychology
https://www.readbyqxmd.com/read/28888714/the-diagnosis-and-management-of-bipolar-i-and-ii-disorders-clinical-practice-update
#5
REVIEW
William V Bobo
Bipolar disorders, including bipolar I disorder (BP-I) and bipolar II disorder (BP-II), are common, potentially disabling, and, in some cases, life-threatening conditions. Bipolar disorders are characterized by alternating episodes of mania or hypomania and depression, or mixtures of manic and depressive features. Bipolar disorders present many diagnostic and therapeutic challenges for busy clinicians. Adequate management of bipolar disorders requires pharmacotherapy and psychosocial interventions targeted to the specific phases of illness...
September 6, 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28883733/fan-the-flame-trazodone-induced-mania-in-a-unipolar-depressed-patient-with-stable-sertraline-treatment
#6
Jianbo Hu, Jianbo Lai, Hanzhi Zheng, Shaohua Hu, Yi Xu
Depressed patients often complain of sleep disturbance. Routine antidepressive strategies sometimes fail to deal with this intractable issue. Indeed, the supplementation of sleep promoting antidepressants (eg, trazodone, mirtazapine, and agomelatine) is prevalent in clinical practice. However, the combination of different antidepressants may increase the affective lability. Herein, we document a patient with unipolar depression who was compliant with sertraline treatment and who dramatically switched to mania after adding trazodone as a sleeping aid...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28882405/efficacy-of-quetiapine-xr-vs-placebo-as-concomitant-treatment-to-mood-stabilizers-in-the-control-of-subthreshold-symptoms-of-bipolar-disorder-results-from-a-pilot-randomized-controlled-trial
#7
Marina Garriga, Eva Solé, Ana González-Pinto, Gabriel Selva-Vera, Belén Arranz, Benedikt L Amann, Jerónimo Saiz-Ruiz, Josefina Pérez-Blanco, Eduard Vieta
Patients with bipolar disorder (BD) do not always achieve full remission between episodes. Subthreshold symptoms (depressive, manic or mixed) represent a major cause of relapse and disability in these patients. Immediate release (IR) and extended release (XR) formulations of quetiapine are both indicated for short and long-term treatment of BD. The aim of this study was to evaluate the efficacy of quetiapine XR vs placebo in subthreshold symptomatology when added to previous mood stabilizer treatment. A pilot phase IIIB, multicentre, prospective, placebo controlled, randomized, double blinded study of 12 weeks follow-up was performed (NCT01197846)...
September 4, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28869209/cost-effectiveness-analysis-of-an-aftercare-service-vs-treatment-as-usual-for-patients-with-severe-mental-disorders
#8
Eshagh Barfar, Vandad Sharifi, Homayoun Amini, Yasaman Mottaghipour, Masud Yunesian, Mehdi Tehranidoost, Payam Sobhebidari, Arash Rashidian
BACKGROUND: There have been claims that community mental health principles leads to the maintenance of better health and functioning in patients and can be more economical for patients with severe and chronic mental disorders. Economic evaluation studies have been used to assess the cost-effectiveness of national health programs, or to propose efficient strategies for health care delivery. AIMS OF THE STUDY: The current study is intended to test the cost-effectiveness of an Aftercare Service when compared with Treatment-As-Usual for patients with severe mental disorders in Iran...
September 1, 2017: Journal of Mental Health Policy and Economics
https://www.readbyqxmd.com/read/28865715/plasma-oxytocin-levels-in-major-depressive-and-bipolar-ii-disorders
#9
Yueh-Ju Lien, Hui Hua Chang, Hsin-Chun Tsai, Yen Kuang Yang, Ru-Band Lu, Po See Chen
Oxytocin may play a role in mood regulation. Research has shown the plasma oxytocin level of patients with bipolar I disorder (BD I) during a manic episode was significantly higher than that of BD I patients of other statuses, and also that of healthy subjects. However, whether or not a difference in the level of oxytocin exists between patients with major depressive disorder (MDD) and those with BD II is unclear. This study aimed to investigate the plasma oxytocin levels in MDD and BD II patients in a depressive episode...
August 30, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28858537/anti-inflammatory-treatments-for-mood-disorders-systematic-review-and-meta-analysis
#10
Muhammad I Husain, Rebecca Strawbridge, Paul Ra Stokes, Allan H Young
BACKGROUND: Recent studies suggest that anti-inflammatory medication may play a role in the treatment of mood disorders. AIMS: The purpose of this study was to determine the efficacy of anti-inflammatory drugs in patients with major depressive disorder and bipolar disorder. METHOD: The Cochrane Central Register of Controlled Trials, PubMed, EMBASE, PsychINFO and Clinicaltrials.gov were searched from inception until 15 April 2017 for completed and on-going randomized controlled trials of anti-inflammatory agents for major depressive disorder and bipolar disorder...
August 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28846801/increased-illness-burden-in-women-with-comorbid-bipolar-and-premenstrual-dysphoric-disorder-data-from-1-099-women-from-step-bd-study
#11
A Slyepchenko, B N Frey, B Lafer, A A Nierenberg, G S Sachs, R S Dias
BACKGROUND: The impact of comorbid premenstrual dysphoric disorder (PMDD) in women with bipolar disorder (BD) is largely unknown. AIMS: We compared illness characteristics and female-specific mental health problems between women with BD with and without PMDD. MATERIALS & METHODS: A total of 1 099 women with BD who participated in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) were studied. Psychiatric diagnoses and illness characteristics were assessed using the Mini International Neuropsychiatric Interview...
August 28, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28843918/the-safety-and-tolerability-of-cariprazine-in-patients-with-manic-or-mixed-episodes-associated-with-bipolar-i-disorder-a-16-week-open-label-study
#12
Terence A Ketter, Gary S Sachs, Suresh Durgam, Kaifeng Lu, Anju Starace, István Laszlovszky, György Németh
BACKGROUND: We evaluated the safety/tolerability of longer-term open-label treatment with cariprazine in patients who had responded to cariprazine for acute bipolar mania. METHODS: In this multinational, multicenter study, open-label, flexible-dose, cariprazine 3-12mg/d was administered for up to 16 weeks to patients (18-65 years) with bipolar mania. Safety evaluations included adverse events (AEs), laboratory values, vital signs, and extrapyramidal symptom (EPS) scales...
August 18, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28843916/anxiety-disorders-and-childhood-maltreatment-as-predictors-of-outcome-in-bipolar-disorder
#13
Barbara Pavlova, Nader Perroud, Paolo Cordera, Rudolf Uher, Martin Alda, Alexandre Dayer, Jean-Michel Aubry
BACKGROUND: Comorbid anxiety disorders and childhood maltreatment have each been linked with unfavourable outcomes in people with bipolar disorder. Because childhood maltreatment is associated with anxiety disorders in this population, their respective predictive value remains to be determined. METHODS: In 174 adults with bipolar disorder, we assessed childhood maltreatment using the Childhood Trauma Questionnaire and lifetime anxiety disorders with the MINI International Neuropsychiatric Interview...
August 18, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28841486/the-effectiveness-of-adjunct-mindfulness-based-intervention-in-treatment-of-bipolar-disorder-a-systematic-review-and-meta-analysis
#14
Che-Sheng Chu, Brendon Stubbs, Tien-Yu Chen, Chia-Hung Tang, Dian-Jeng Li, Wei-Cheng Yang, Ching-Kuan Wu, André F Carvalho, Eduard Vieta, David J Miklowitz, Ping-Tao Tseng, Pao-Yen Lin
BACKGROUND: Mindfulness-based interventions (MBIs) have been increasingly used as an adjunctive treatment to pharmacotherapy for a few psychiatric disorders. However, few studies have investigated the efficacy of MBIs in bipolar disorder (BD). METHODS: We performed a systematic review and meta-analysis to evaluate the efficacy of MBIs as an adjunctive treatment in BD. Major electronic databases were independently searched by two authors for controlled and uncontrolled studies which examined the effects of MBIs on psychiatric symptoms in subjects with BD...
August 16, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28841485/exploration-of-comorbid-obsessive-compulsive-disorder-in-patients-with-bipolar-disorder-the-clinic-based-prevalence-rate-symptoms-nature-and-clinical-correlates
#15
Sehyun Jeon, Ji Hyun Baek, So Yung Yang, Yujin Choi, Sung Woo Ahn, Kyooseob Ha, Kyung Sue Hong
BACKGROUND: Comorbidity of bipolar disorder (BD) and obsessive-compulsive disorder (OCD) has received clinical attention. However, the detailed nature and nolosogic validity of the comorbidity have not been fully explored. This study investigated the comorbidity rate, clinical nature, and correlates of OCD in patients with BD. METHODS: Patients (n = 314) with BD were recruited and lifetime clinical characteristics were evaluated comprehensively. The comorbid OCD ('OCD-BD') group and the 'non-OC BD' group were compared in terms of the clinical variables of BD...
August 15, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28833953/mixed-state-and-suicide-is-the-effect-of-mixed-state-on-suicidal-behavior-more-than-the-sum-of-its-parts
#16
Jane E Persons, William H Coryell, David A Solomon, Martin B Keller, Jean Endicott, Jess G Fiedorowicz
OBJECTIVE: To assess whether suicidal behavior during mixed states exceeds that expected from the manic or depressive components alone. METHODS: This study included 429 participants with bipolar disorder from the National Institute of Mental Health Collaborative Depression Study (CDS). Mood and suicidal behavior were captured using the Longitudinal Interval Follow-up Evaluation and the Schedule of Affective Disorders and Schizophrenia. Suicidal behavior during each mood state, relative to euthymia, was analyzed using Cox regression to allow for repeated events, with a frailty term to account for intra-participant correlation...
August 23, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28833866/total-sleep-time-and-kynurenine-metabolism-associated-with-mood-symptom-severity-in-bipolar-disorder
#17
Dahlia Mukherjee, Venkatesh Bassapa Krishnamurthy, Caitlin E Millett, Aubrey Reider, Adem Can, Maureen Groer, Dietmar Fuchs, Teodor T Postolache, Erika F H Saunders
OBJECTIVE: Chronic, low-level inflammation is associated with symptomatic bipolar disorder (BD) and with chronic insomnia. Disrupted sleep is a feature of episodes of both mania and depression. We examined the effect of neopterin, a marker of cellular immune activation, and kynurenine (KYN), an inflammatory byproduct of the serotonin pathway, on the association between total sleep time and depression severity in BD. METHOD: Twenty-one symptomatic BD participants and 28 healthy controls (HC) were recruited and followed during usual clinical care...
August 23, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28827867/a-factor-analytical-study-report-on-mania-from-nepal
#18
Sanjeev Shah, Tapas Kumar Aich, Sandip Subedi
BACKGROUND AND OBJECTIVES: Phenomenological studies on mood disorder are rare in Nepal which prompted us to undertake the current factor analytical study of mania. MATERIALS AND METHODS: It was a cross-sectional descriptive study for which we did purposive sampling technique according to certain inclusion and exclusion criteria. The study sample consists of fifty patients, who fulfilled the International Classification of Diseases, Tenth Edition (ICD-10) diagnostic criteria for Manic Episode and/or Bipolar Affective Disorder-current episode mania...
April 2017: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28818612/epidemiological-and-clinical-variables-related-with-the-predominant-polarity-on-bipolar-disorder-a-systematic-review
#19
Jesús García-Jiménez, Marisol Álvarez-Fernández, Lidia Aguado-Bailón, Luis Gutiérrez-Rojas
INTRODUCTION: Current classification of bipolar disorder (BD) in type i or type ii, however useful, may be insufficient to provide relevant clinical information in some patients. As a result, complementary classifications are being proposed, like the predominant polarity (PP) based, which is defined as a clear tendency in the patient to present relapses in the manic or depressive poles. METHODS: We carried out a search in PubMed and Web of Science databases, following the Preferred Items for Reporting of Systematic Reviews and Meta-Analyses -PRISMA- guidelines, to identify studies about BD reporting PP...
August 14, 2017: Revista de Psiquiatrí́a y Salud Mental
https://www.readbyqxmd.com/read/28817490/an-open-trial-of-iloperidone-for-mixed-episodes-in-bipolar-disorder
#20
Vivek Singh, Jodi Gonzalez Arnold, Thomas J Prihoda, Melissa Martinez, Charles L Bowden
BACKGROUND: Mixed mood states in bipolar disorder are difficult to treat and when present indicate worse illness trajectories. Several medications are US Food and Drug Administration approved to treat mixed episodes; however, the clinical trials have been short term and rarely reported depression response. METHODS: We conducted a 5-month open-label trial examining the tolerability and efficacy of iloperidone for bipolar disorder mixed episodes. RESULTS: Mania and depression scores significantly improved over the course of the study for study completers (ie, 60%-68% improvement for manic symptoms and 41%-49% for depression symptoms)...
October 2017: Journal of Clinical Psychopharmacology
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