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https://www.readbyqxmd.com/read/29778054/at-risk-symptoms-of-bipolar-disorder-in-a-university-student-cohort
#1
Ida S Haussleiter, Sandra Lorek, Eike Zeschel, Svenja Mattausch, Milena Meyers, Georg Juckel
To assess the occurrence and frequency of bipolar at-risk symptoms in a large sample of previously undiagnosed students using the new screening tool Bochumer Screeningbogen Bipolar (BSB). 2329 students of the Ruhr-University Bochum, Germany completed online demographic data as well as various self-rating questionnaires (BSB; Hypomania Checklist 32; Altman Self-Rating Mania Scale; Beck Depression Inventory). Within the student cohort (64.4% female, mean age 24.3 years) every fifth student currently suffered from moderate to severe depressive symptoms; every sixth student had already thought about suicide and every other student reported a history of mood swings...
May 6, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29776917/treatment-refractory-mania-with-psychosis-in-a-post-transplant-patient-on-tacrolimus-a-case-report
#2
Muaid Ithman, Kunal Malhotra, Meelie Bordoloi, Garima Singh
Bipolar affective disorder type I imparts significant morbidity and disease burden in the Population. It is characterized by occurrence of one or more manic episodes which may be preceded or followed by a depressive or hypomanic phase. About half of these manic episodes are characterized by the presence of psychotic features [1]. The condition is further complicated when patient has multiple comorbid conditions. We report here a case of a 66 year old Caucasian female, previously diagnosed with Bipolar disorder who developed treatment refractory mania with psychotic feature after being on Tacrolimus (an immunosuppressive agent) after kidney transplantation...
May 18, 2018: Clinical Medicine & Research
https://www.readbyqxmd.com/read/29775085/usage-of-therapeutic-sleep-deprivation-a-survey-in-psychiatric-hospitals-in-austria-germany-and-switzerland
#3
Dietmar Winkler, Marie Spies, Yasmin Al-Resheg, Joseph C Wu, William E Bunney, Blynn G Bunney, Siegfried Kasper, Edda Pjrek
OBJECTIVE: Therapeutic sleep deprivation (SD) is a nonpharmacological treatment that is used most often for depression. The aim of this study was to examine the pattern of use of SD in psychiatric hospitals in Austria, Germany, and Switzerland. METHODS: A questionnaire about perceived usage of SD was sent by mail to all 511 psychiatric hospitals in the three countries. Nonresponders were asked to answer the questionnaire by phone. We achieved a response rate of 75...
May 18, 2018: Behavioral Sleep Medicine
https://www.readbyqxmd.com/read/29768498/genomic-variants-in-an-inbred-mouse-model-predict-mania-like-behaviors
#4
Michael C Saul, Sharon A Stevenson, Changjiu Zhao, Terri M Driessen, Brian E Eisinger, Stephen C Gammie
Contemporary rodent models for bipolar disorders split the bipolar spectrum into complimentary behavioral endophenotypes representing mania and depression. Widely accepted mania models typically utilize single gene transgenics or pharmacological manipulations, but inbred rodent strains show great potential as mania models. Their acceptance is often limited by the lack of genotypic data needed to establish construct validity. In this study, we used a unique strategy to inexpensively explore and confirm population allele differences in naturally occurring candidate variants in a manic rodent strain, the Madison (MSN) mouse strain...
2018: PloS One
https://www.readbyqxmd.com/read/29764272/does-s100b-have-a-potential-role-in-affective-disorders-a-literature-review
#5
Hilda Kroksmark, Maj Vinberg
BACKGROUND: S100B is a calcium-binding protein located in glial cells; it is regarded as a potential biomarker in affective disorders. AIM: To review the literature investigating the role of S100B in patients with affective disorders. METHOD: A systematic review of original English language studies investigating S100B in serum, cerebrospinal fluid, plasma and lymphocytes, in patients with affective disorders, was conducted. The literature search was conducted within the PubMed database...
May 15, 2018: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/29756288/mixed-states-in-bipolar-and-major-depressive-disorders-systematic-review-and-quality-appraisal-of-guidelines
#6
REVIEW
N Verdolini, D Hidalgo-Mazzei, A Murru, I Pacchiarotti, L Samalin, A H Young, E Vieta, A F Carvalho
OBJECTIVE: This systematic review provided a critical synthesis and a comprehensive overview of guidelines on the treatment of mixed states. METHOD: The MEDLINE/PubMed and EMBASE databases were systematically searched from inception to March 21st, 2018. International guidelines covering the treatment of mixed episodes, manic/hypomanic, or depressive episodes with mixed features were considered for inclusion. A methodological quality assessment was conducted with the Appraisal of Guidelines for Research and Evaluation-AGREE II...
May 13, 2018: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29739135/unipolar-mania-a-particular-aspect-of-bipolar-disorder-in-tunisia
#7
Badii Amamou, Wafa Chebbi, Myriam Allegue, Ahmed Mhalla, Ferid Zaafrane, Lotfi Gaha
Objective: Unipolar mania is a clinical reality in our daily practice. Many authors suggested that bipolar patients can have only manic episodes without depressions. These findings lead us to explore more this particularity. Methods: We conduct a retrospective, descriptive and comparative study including 173 patients, followed for bipolar disorder type I, according to the Diagnostic and Statistical Manual of Mental Disorders fifth edition criteria, during the period between January 2008 and December 2015...
May 31, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29734096/does-recent-mania-affect-response-to-antidepressants-in-bipolar-disorder-a-re-analysis-of-step-bd-data
#8
Zahra Mousavi, Sheri Johnson, Descartes Li
BACKGROUND: One previous study suggested that the presence of a manic episode before bipolar depression is related to worse response to antidepressants. METHOD: To examine this effect in a larger sample, we used data from the large, multi-site STEP-BD study. We hypothesized that among persons treated with antidepressants for bipolar depression, manic or mixed episodes before depression onset (as compared to euthymia) would predict lower rate of recovery, more sustained depressive symptoms and higher rate of switching into mania/hypomania after antidepressant treatment of bipolar depression...
April 22, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29726004/factors-associated-with-poor-functional-outcome-in-bipolar-disorder-sociodemographic-clinical-and-neurocognitive-variables
#9
J Sanchez-Moreno, C M Bonnin, A González-Pinto, B L Amann, B Solé, V Balanzá-Martinez, C Arango, E Jiménez, R Tabarés-Seisdedos, M P Garcia-Portilla, A Ibáñez, J M Crespo, J L Ayuso-Mateos, A Martinez-Aran, C Torrent, E Vieta
OBJECTIVE: The current investigation aimed at studying the sociodemographic, clinical, and neuropsychological variables related to functional outcome in a sample of euthymic patients with bipolar disorder(BD) presenting moderate-severe levels of functional impairment. METHODS: Two-hundred and thirty-nine participants with BD disorders and with Functioning Assessment Short Test(FAST) scores equal or above 18 were administered a clinical and diagnostic interview, and the administration of mood measure scales and a comprehensive neuropsychological battery...
May 3, 2018: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29723656/white-matter-microstructure-alterations-correlate-with-terminally-differentiated-cd8-effector-t-cell-depletion-in-the-peripheral-blood-in-mania-combined-dti-and-immunological-investigation-in-the-different-phases-of-bipolar-disorder
#10
Paola Magioncalda, Matteo Martino, Samuele Tardito, Bruno Sterlini, Benedetta Conio, Valentina Marozzi, Giulia Adavastro, Laura Capobianco, Daniel Russo, Alessia Parodi, Francesca Kalli, Giorgia Nasi, Tiziana Altosole, Niccolò Piaggio, Georg Northoff, Daniela Fenoglio, Matilde Inglese, Gilberto Filaci, Mario Amore
BACKGROUND: White matter (WM) microstructural abnormalities and, independently, signs of immunological activation were consistently demonstrated in bipolar disorder (BD). However, the relationship between WM and immunological alterations as well as their occurrence in the various phases of BD remain unclear. METHOD: In 60 type I BD patients - 20 in manic, 20 in depressive, 20 in euthymic phases - and 20 controls we investigated: (i) diffusion tensor imaging (DTI)-derived fractional anisotropy (FA), radial diffusivity (RD) and axial diffusivity (AD) using a tract-based spatial statistics (TBSS) approach; (ii) circulating T cell subpopulations frequencies, as well as plasma levels of different cytokines; (iii) potential relationships between WM and immunological data...
April 30, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29720950/sensorimotor-gating-in-depressed-and-euthymic-patients-with-bipolar-disorder-analysis-on-prepulse-inhibition-of-acoustic-startle-response-stratified-by-gender-and-state
#11
Junko Matsuo, Miho Ota, Shinsuke Hidese, Toshiya Teraishi, Hiroaki Hori, Ikki Ishida, Moeko Hiraishi, Hiroshi Kunugi
Background: Prepulse inhibition (PPI) of the acoustic startle reflex is an operational measure of sensorimotor gating. The findings on PPI deficits in bipolar disorder (BD) are inconsistent among studies due to various confounding factors such as gender. This study aimed to assess sensorimotor gating deficits in patients with BD stratified by gender and state (depressed/euthymic), and to explore related clinical variables. Methods: Subjects were 106 non-manic BD patients (26 BD I and 80 BD II; 63 with depression and 43 euthymic) and 232 age-, gender-, and ethnicity-matched (Japanese) healthy controls...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29705489/rest-activity-rhythm-profiles-associated-with-manic-hypomanic-and-depressive-symptoms
#12
Stephen F Smagula, Robert T Krafty, Julian F Thayer, Daniel J Buysse, Martica H Hall
Rest-activity rhythm (RAR) disturbances are associated with mood disorders. But there remains a need to identify the particular RAR profiles associated with psychiatric symptom dimensions. Establishing such profiles would support the development of tools that track the 24-h sleep-wake phenotypes signaling clinical heterogeneity. We used data-driven clustering to identify RAR profiles in 145 adults aged 36-82 years (mean = 60, standard deviation = 9). Then we evaluated psychiatric symptom dimensions (including positive and negative affect, depressive, manic-hypomanic, panic-agoraphobic, and substance use symptoms) associated with these empirically-derived RAR profiles...
April 21, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29698917/a-mania-related-memory-bias-is-associated-with-risk-for-relapse-in-bipolar-disorder
#13
Thomas D Meyer, Martin Hautzinger, Isabelle E Bauer
OBJECTIVE: Previous work has shown that neuropsychological performance can predict outcome of psychotherapy. The present paper explores whether an affective bias in verbal memory is associated with recurrence of mood episodes in patients with Bipolar Disorder (BD). METHOD: 76 euthymic adult patients with BD were randomly assigned to either 9 months of Cognitive Behavioral Therapy (CBT) or Support Therapy (ST), and followed up for 2 years after completing therapy...
April 7, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29674982/delusional-themes-across-affective-and-non-affective-psychoses
#14
Angelo Picardi, Laura Fonzi, Mauro Pallagrosi, Antonella Gigantesco, Massimo Biondi
The current debate about the diagnostic significance of delusion revolves around two positions. The neurocognitive position conceives delusion as a non-specific, though polymorphic, symptom. The psychopathological position views features of delusion such as content and structure as having meaningful connections with diagnostic entities. This study aims at contributing to this debate by examining the association between delusional themes and diagnosis in a sample of 830 adult psychotic patients. All diagnoses were made by experienced psychiatrists according to DSM-IV or ICD-10 criteria, and in 348 patients were established with the SCID-I...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29674601/the-relationship-between-the-number-of-manic-episodes-and-oxidative-stress-indicators-in-bipolar-disorder
#15
Süleyman Akarsu, Abdullah Bolu, Emre Aydemir, Selma Bozkurt Zincir, Yasemin Gülcan Kurt, Serkan Zincir, Murat Erdem, Özcan Uzun
Objective: Bipolar disorder (BD) is a chronic mood disorder characterized by recurrent episodes that has a lifetime prevalence of 0.4- 5.5%. The neurochemical mechanism of BD is not fully understood. Oxidative stress in neurons causes lipid peroxidation in proteins associated with neuronal membranes and intracellular enzymes and it may lead to dysfunction in neurotransmitter reuptake and enzyme activities. These pathological processes are thought to occur in brain regions associated with affective functions and emotions in BD...
April 20, 2018: Psychiatry Investigation
https://www.readbyqxmd.com/read/29672801/antisuicidal-effects-in-mood-disorders-are-they-unique-to-lithium
#16
Leonardo Tondo, Ross J Baldessarini
INTRODUCTION: Suicidal behavior is strongly associated with depression in major depressive (MDD) and bipolar (BD) disorders, especially with associated behavioral activation, dysphoria, or agitation. A rare intervention with evidence of suicide risk-reducing as well as mood-stabilizing effects in mood disorder patients is lithium. METHODS: We reviewed available research evidence on associations of long-term treatment with lithium with risk of suicidal behavior. We meta-analyzed 12 randomized trials in 10 reports (with at least 1 suicide in either treatment arm) including both BD and MDD subjects, with particular attention to comparisons of lithium with placebo or other pharmacological treatments...
April 19, 2018: Pharmacopsychiatry
https://www.readbyqxmd.com/read/29667796/isotretinoin-the-ups-are-just-as-troubling-as-the-downs
#17
Jay M Truitt, Jason S Reichenberg, Kevin G Sharghi, Shirlene M Sampson, Randall K Roenigk, Michelle Magid
INTRODUCTION: Isotretinoin, previously marketed as Accutane®, is an oral retinoid medication that is used to treat acne and other cutaneous disorders. Although the data is conflicting, previous reports suggest a causal relationship between isotretinoin and depression. When reviewing these previous reports, many patients who were diagnosed as 'depressed' did not undergo a thorough psychiatric evaluation and/or were not diagnosed according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders (DSM)...
April 18, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29666369/lithium-associated-transcriptional-regulation-of-crmp1-in-patient-derived-olfactory-neurons-and-symptom-changes-in-bipolar-disorder
#18
Charlee K McLean, Soumya Narayan, Sandra Y Lin, Narayan Rai, Youjin Chung, MariaMananita S Hipolito, Nicola G Cascella, John I Nurnberger, Koko Ishizuka, Akira S Sawa, Evaristus A Nwulia
There is growing evidence that lithium used in the treatment of bipolar disorder (BD) affects molecular targets that are involved in neuronal growth, survival, and maturation, but it remains unclear if neuronal alterations in any of these molecules predict specific symptom changes in BD patients undergoing lithium monotherapy. The goals of this study were to (a) determine which molecular changes in the olfactory neurons of symptomatic patients receiving lithium are associated with antimanic or antidepressant response, and (b) uncover novel intraneuronal regulatory mechanisms of lithium therapy...
April 18, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29657926/efficacy-of-group-cognitive-behavioral-therapy-in-maintenance-treatment-and-relapse-prevention-for-bipolar-adolescents
#19
Soroor Arman, Farnaz Golmohammadi, Mohammadreza Maracy, Mitra Molaeinezhad
Background: Despite conducting wide-ranging of pharmacotherapy for bipolar adolescents, many of them are showing a deficit in functioning with high relapse rate. The aim of the current study was to develop a manual and investigate the efficacy of group cognitive-behavioral therapy (G-CBT) for female bipolar adolescents. Materials and Methods: During the first qualitative phase of a mixed-methods study, a manual of G-CBT was developed. Then, 32 female bipolar adolescents aged 12-19 years old, receiving usual maintenance medications (UMM), were selected...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29653349/the-role-of-lifetime-anxiety-history-in-the-course-of-bipolar-spectrum-disorders
#20
Madison K Titone, Rachel D Freed, Jared K O'Garro-Moore, Andrew Gepty, Tommy H Ng, Jonathan P Stange, Lyn Y Abramson, Lauren B Alloy
Individuals with bipolar spectrum disorder (BSD) frequently meet criteria for comorbid anxiety disorders, and anxiety may be an important factor in the etiology and course of BSDs. The current study examined the association of lifetime anxiety disorders with prospective manic/hypomanic versus major depressive episodes. Participants were 244 young adults (aged 17-26) with milder forms of BSDs (i.e., bipolar-II, cyclothymia, BD-NOS). First, bivariate analyses assessed differences in baseline clinical characteristics between participants with and without DSM-IV anxiety diagnoses...
April 3, 2018: Psychiatry Research
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