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https://www.readbyqxmd.com/read/29339689/atherogenic-index-of-plasma-as-a-cardiovascular-risk-marker-in-manic-depressive-and-euthymic-stages-of-bipolar-disorder
#1
Tevfik Kalelioğlu, Pelin Ünalan, Burcu Kök, Şule Sözen, Özge Yüksel, Mustafa Akkuş, Refik Cihnioğlu, Nesrin Karamustafalıoğlu
OBJECTIVE: Individuals with bipolar disorder (BD) frequently suffer from cardiovascular disease (CVD), and it is a leading cause of mortality. Clinicians use routine laboratory tests, including a lipid profile, to predict cardiovascular risk. In addition, a particular lipid ratio, the atherogenic index of plasma (AIP), is a sensitive, new parameter that can be used to assess highrisk groups. To our knowledge, this is the first study evaluating cardiovascular risk via AIP in different stages of BD...
January 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/29327316/-diagnosis-differential-diagnosis-and-therapy-of-substance-use-disorders-in-general-hospital-general-section
#2
REVIEW
Anton Schmick, Josef Jenewein, Sönke Böttger
Substance use disorders are becoming an increasingly significant problem in general hospitals and hence play a key role in consultation- and liaison psychiatry. Diverse psychotropic effects of various substances mimic psychiatric disorders. An alcohol intoxication can present depressive or manic symptoms, a cannabis delirium can present as a psychosis while stimulants use can suggest the diagnosis of an anxiety disorder. Obtaining dual diagnoses by identifying substance-induced and non-substance-induced psychopathologies is clinically challenging...
January 11, 2018: Neuropsychiatrie: Klinik, Diagnostik, Therapie und Rehabilitation
https://www.readbyqxmd.com/read/29316081/alterations-of-the-cerebellum-and-basal-ganglia-in-bipolar-disorder-mood-states-detected-by-quantitative-t1%C3%AF-mapping
#3
Casey P Johnson, Gary E Christensen, Jess G Fiedorowicz, Merry Mani, Joseph J Shaffer, Vincent A Magnotta, John A Wemmie
OBJECTIVES: Quantitative mapping of T1 relaxation in the rotating frame (T1ρ) is a magnetic resonance imaging technique sensitive to pH and other cellular and microstructural factors, and is a potentially valuable tool for identifying brain alterations in bipolar disorder. Recently, this technique identified differences in the cerebellum and cerebral white matter of euthymic patients vs healthy controls that were consistent with reduced pH in these regions, suggesting an underlying metabolic abnormality...
January 7, 2018: Bipolar Disorders
https://www.readbyqxmd.com/read/29314557/assessment-of-cognitive-functions-in-bipolar-i-disorder-a-1-year-naturalistic-follow-up-study
#4
Rajesh Sagar, Anamika Sahu, Raman Deep Pattanayak, Biswadip Chatterjee
OBJECTIVE: Available findings from cross-sectional studies have demonstrated cognitive impairments in bipolar I disorder (BD-I) during various phases of illness. However, very little is known about the longitudinal course of these cognitive impairments. The purpose of the study was to explore the longitudinal pattern of changes in cognitive functioning of BD-I patients. METHODS: A total of 129 BD-I subjects (manic, depressed and euthymic groups) and 49 healthy controls were recruited using predefined selection criteria...
January 4, 2018: Bipolar Disorders
https://www.readbyqxmd.com/read/29310066/is-recurrence-in-major-depressive-disorder-related-to-bipolarity-and-mixed-features-results-from-the-bridge-ii-mix-study
#5
Lorenzo Mazzarini, Georgios D Kotzalidis, Daria Piacentino, Salvatore Rizzato, Jules Angst, Jean-Michel Azorin, Charles L Bowden, Sergey Mosolov, Allan H Young, Eduard Vieta, Paolo Girardi, Giulio Perugi
BACKGROUND: Current classifications separate Bipolar (BD) from Major Depressive Disorder (MDD) based on polarity rather than recurrence. We aimed to determine bipolar/mixed feature frequency in a large MDD multinational sample with (High-Rec) and without (Low-Rec) >3 recurrences, comparing the two subsamples. METHODS: We measured frequency of bipolarity/hypomanic features during current depressive episodes (MDEs) in 2347 MDD patients from the BRIDGE-II-mix database, comparing High-Rec with Low-Rec...
January 2, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29308715/exploring-the-relationship-between-vitamin-d-and-mania-correlations-between-serum-vitamin-d-levels-and-disease-activity
#6
Neslihan Altunsoy, Rabia Nazik Yüksel, Merve Cingi Yirun, Ayşegül Kılıçarslan, Çiğdem Aydemir
BACKGROUND: Several studies suggest an association between hypovitaminosis D and mood disorders including major depressive disorder, seasonal affective disorder and premenstrual dysphoric disorder. On the other hand, there is not enough study about acute manic episode and hypovitaminosis D. This data insufficient zone led us to study on whether vitamin D deficiency is associated with acute manic episode and has an impact on disease activity Methods: Thirty-one patients with bipolar disorder in remission, 26 patients with acute manic episode and 40 healthy controls with no major psychopathology were recruited in this study...
January 7, 2018: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/29284814/a-rare-presentation-of-a-case-of-obsessive-compulsive-disorder-comorbid-with-bipolar-affective-disorder
#7
Nimmy Chandran, Arpit Parmar, Koushik Sinha Deb
Obsessive-compulsive disorder (OCD) is a chronic illness with waxing and waning course. OCD is not uncommonly found to be comorbid with bipolar affective disorder (BPAD). The course and prognosis of OCD have distinctive features in such cases. Only rarely symptoms of OCD emerge during mania in such individuals. We hereby report a very unusual case of OCD comorbid with BPAD in which obsession and compulsion symptoms occurred only during manic episodes with complete remission during periods between manic episodes (including during depressive episodes)...
November 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/29283064/glycogen-synthase-kinase-3%C3%AE-as-a-putative-therapeutic-target-for-bipolar-disorder
#8
Manoj P Dandekar, Samira S Valvassori, Gustavo Colombo Dal-Pont, Joao L DeQuevedo
BACKGROUND: Bipolar disorder (BD) is a debilitating mental ailment characterized by recurrent episodes of mania and depression. Primary mood-stabilizing drugs like lithium and valproate alleviate the hypomanic or mild to moderate manic episodes in patients with BD. One of the extensively studied underlying mechanisms for these pharmacological interventions is inhibition of intracellular signaling cascades associated with glycogen synthase kinase-3 beta (GSK-3β), a multi-functional serine-threonine kinase...
December 27, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/29280686/state-dependent-alterations-of-lipid-profiles-in-patients-with-bipolar-disorder
#9
Yu-Jui Huang, Shang-Ying Tsai, Kuo-Hsuan Chung, Pao-Huan Chen, Shou-Hung Huang, Chian-Jue Kuo
Objective Serum lipid levels may be associated with the affective severity of bipolar disorder, but data on lipid profiles in Asian patients with bipolar disorder and the lipid alterations in different states of opposite polarities are scant. We investigated the lipid profiles of patients in the acute affective, partial, and full remission state in bipolar mania and depression. Methods The physically healthy patients aged between 18 and 45 years with bipolar I disorder, as well as age-matched healthy normal controls were enrolled...
January 1, 2017: International Journal of Psychiatry in Medicine
https://www.readbyqxmd.com/read/29280477/mood-disorders-and-prospective-suicidality-in-young-adults-a-population-based-cohort-study
#10
D C Vieira, T de Azevedo Cardoso, T C Mondin, K Jansen, R A da Silva, L D de Mattos Souza, F Kapczinski, P V S Magalhães
OBJECTIVE: To assess the prospective associations of mood disorders and suicidality in a community sample of young adults from south Brazil. METHOD: Prospective population-based cohort study. Young adults (18-24 years old) were recruited and followed up on 5 years later; people were interviewed at their homes. Suicidality, as well as mood and anxiety disorders, was assessed using the Mini-International Neuropsychiatric Interview. The impact of mood episodes on suicidality was both evaluated when they occurred in the same wave (a current episode) and when suicidality occurred prospectively, with suicidality measured at follow-up (a past episode)...
December 27, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29275445/issues-on-the-diagnosis-and-etiopathogenesis-of-mood-disorders-reconsidering-dsm-5
#11
REVIEW
Kazuyoshi Ogasawara, Yukako Nakamura, Hiroyuki Kimura, Branko Aleksic, Norio Ozaki
The authors present a narrative review from the diagnostic and nosologic viewpoints of mood disorders (bipolar and depressive ones) by revisiting the revision from the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders, Text Revision to DSM-5, including the following: the separation of the bipolar and depressive sections; the addition of increased energy and continuation of symptoms to the hypo/manic criteria; the elimination of mixed episodes; the creation of new categories and specifiers ("other specified bipolar and related disorder", "disruptive mood dysregulation disorder", "with anxious distress", "with mixed features", "with peripartum onset"); the categorization of hypo/manic episodes during antidepressant treatment into bipolar disorder; the elimination of the "bereavement exclusion"; the ambiguous separation between bipolar I and II; the insufficient distinction between "other specified bipolar and related disorders" and major depressive disorder; the differentiation regarding borderline personality disorder; agitation; premenstrual dysphoric disorder; and society and psychiatry...
December 23, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29249805/clustered-repetitive-transcranial-magnetic-stimulation-for-the-prevention-of-depressive-relapse-recurrence-a-randomized-controlled-trial
#12
Hua-Ning Wang, Xiao-Xia Wang, Rui-Guo Zhang, Ying Wang, Min Cai, Ya-Hong Zhang, Run-Zhu Sun, Li Guo, Yu-Ting Qiao, Jun-Chang Liu, Hong He, Zhong-Heng Wang, Yu-Chen Wan, Qing-Rong Tan, Zhang-Jin Zhang
Repetitive transcranial magnetic stimulation (rTMS) may have the potential to prevent depressive relapse. This assessor-blinded, randomized controlled study was designed to evaluate the efficacy and safety of rTMS as a mono- and combination therapy in the prevention of depressive relapse/recurrence. A total of 281 depressed patients who had achieved stable full or partial remission on a 6-month antidepressant (ADP) run-in treatment were randomly assigned to an rTMS (n = 91), ADP (n = 108), or combined (rTMS + ADP, n = 82) treatment group for 12 months...
December 18, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/29248821/psychometric-properties-of-the-well-being-index-who-5-spanish-version-in-a-sample-of-euthymic-patients-with-bipolar-disorder
#13
C M Bonnín, L N Yatham, E E Michalak, A Martínez-Arán, T Dhanoa, I Torres, C Santos-Pascual, E Valls, A F Carvalho, J Sánchez-Moreno, M Valentí, I Grande, D Hidalgo-Mazzei, E Vieta, M Reinares
BACKGROUND: The concept of well-being which focuses on positive emotions has received increased research attention. However, a consensus definition of this term is lacking. The Well-Being Index scale (WHO-5) is a generic, self-report scale that contains five Likert-type items to evaluate psychological well-being. This construct may provide a relevant outcome in bipolar disorder (BD) research and care beyond the rating of mood symptoms. Thus, in the current study, the psychometric properties of the WHO-5 Spanish version were assessed in a sample of euthymic patients with BD...
December 6, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29241358/criticisms-of-kraepelin-s-psychiatric-nosology-1896-1927
#14
Kenneth S Kendler, Eric J Engstrom
Emil Kraepelin's psychiatric nosology, proposed in the 5th and 6th editions of his textbook published in 1896 and 1899, did not quickly gain worldwide acceptance, but was instead met with substantial and sustained criticism. The authors review critiques of Kraepelin's work published in his lifetime by Adolf Meyer, Friedrich Jolly, Eugenio Tanzi, Alfred Hoche, Karl Jaspers, and Willy Hellpach. These critics made six major points. First, Kraepelin's new categories of dementia praecox and manic-depressive insanity were too broad and too heterogeneous...
December 15, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29232923/an-oldie-but-goodie-lithium-in-the-treatment-of-bipolar-disorder-through-neuroprotective-and-neurotrophic-mechanisms
#15
REVIEW
Eunsoo Won, Yong-Ku Kim
Lithium has been used for the treatment of bipolar disorder (BD) for the last sixty or more years, and recent studies with more reliable designs and updated guidelines have recommended lithium to be the treatment of choice for acute manic, mixed and depressive episodes of BD, along with long-term prophylaxis. Lithium's specific mechanism of action in mood regulation is progressively being clarified, such as the direct inhibition on glycogen synthase kinase 3β, and its various effects on neurotrophic factors, neurotransmitters, oxidative metabolism, apoptosis, second messenger systems, and biological systems are also being revealed...
December 11, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29228982/electroconvulsive-therapy-for-manic-state-with-mixed-and-psychotic-features-in-a-teenager-with-bipolar-disorder-and-comorbid-episodic-obsessive-compulsive-disorder-a-case-report
#16
Olof Rask, Klara Suneson, Eva Holmström, Beata Bäckström, Björn Axel Johansson
BACKGROUND: Comorbidity of bipolar disorder and obsessive-compulsive disorder is common in adolescence. Obsessive-compulsive disorder symptoms may be episodic and secondary to alterations in mood, and display specific features. Management of pediatric bipolar disorder-obsessive-compulsive disorder is challenging, as pharmacotherapy of obsessive-compulsive disorder may induce or exacerbate manic episodes and there is limited evidence of treatment efficacy. Electroconvulsive therapy is sparsely used in children and adolescents, but is documented to be a safe and efficacious intervention in adults with bipolar disorder...
December 12, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29216557/subcortical-volumetric-differences-between-clinical-stages-of-young-people-with-affective-and-psychotic-disorders
#17
Peta S Eggins, Sean N Hatton, Daniel F Hermens, Ian B Hickie, Jim Lagopoulos
The aim of this study was to investigate differences in subcortical and hippocampal volumes between healthy controls, young people at an early stage of affective and psychotic disorders and those in more advanced stages, to identify markers associated with functional outcomes and illness severity. Young people presenting to youth mental health services with admixtures of depressive, manic and psychotic symptoms (n = 141), and healthy counterparts (n = 49), aged 18-25 were recruited. Participants underwent magnetic resonance imaging, clinical assessments and were rated as to their current clinical stage...
November 28, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29209876/mentalization-deficit-in-bipolar-patients-during-an-acute-depressive-and-manic-episode-association-with-cognitive-functions
#18
Anna Bodnar, Janusz K Rybakowski
BACKGROUND: A number of studies in bipolar patients have shown a deficit in mentalization (theory of mind), one of the main aspects of social cognition. The aim of current study was to assess both cognitive and affective mentalization in well-defined groups of depressed and manic bipolar patients, compared to healthy control subjects, using a battery of tests measuring mentalization processes. The second aim was to investigate a possible relationship between cognitive and affective mentalization and cognitive functions in bipolar patients during a depressive and manic episode...
December 6, 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/29209374/mental-health-assessment-of-south-korean-adults-on-probation
#19
Soungwan Kim, Bongseog Kim
Objective: The association of offender mental illness (including those on probation) with crime has long been the subject of social interest; however, systematic management has been insufficient. The study purpose was to analyze mental illness prevalence, proportion of first offenses and recidivism with the mental illness of those on probation. Methods: A total of 206 adults on probation were divided into groups (first offenders and repeat offenders) and they completed self-report instruments and clinical interviews designed to diagnose mental illness...
November 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/29200575/are-we-overdiagnosing-bipolar-disorder
#20
M S Reddy, Starlin M Vijay, Swetha Reddy
Bipolar disorder (BD) is an established diagnostic entity used by clinicians for over a century. It is distinguished by the distinct manic and depressive episodes with interepisode euthymia. It has an illness course where both recovery and recurrences are a rule and has a good long-term prognosis, as reported earlier by Emil Kraeplin. There is an opinion in the current literature that BD is often underdiagnosed as unipolar depression, and based on that opinion, spectrum concept was introduced. Here, we present 5 cases to highlight that overdiagnosis of BD is also not infrequent and we discuss its reasons and therapeutic implications...
September 2017: Indian Journal of Psychological Medicine
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