keyword
https://read.qxmd.com/read/38392036/the-growing-understanding-of-the-pituitary-implication-in-the-pathogenesis-of-long-covid-19-syndrome-a-narrative-review
#21
REVIEW
Ach Taieb, Ben Haj Slama Nassim, Gorchane Asma, Methnani Jabeur, Saad Ghada, Ben Abdelkrim Asma
Long COVID-19, also known as post-acute sequelae of SARS-CoV-2 infection, is a condition where individuals who have recovered from the acute phase of COVID-19 continue to experience a range of symptoms for weeks or even months afterward. While it was initially thought to primarily affect the respiratory system, it has become clear that Long COVID-19 can involve various organs and systems, including the endocrine system, which includes the pituitary gland. In the context of Long COVID-19, there is a growing understanding of the potential implications for the pituitary gland...
February 14, 2024: Advances in Respiratory Medicine
https://read.qxmd.com/read/38377443/does-menopause-hormone-therapy-improve-symptoms-of-depression-findings-from-a-specialized-menopause-clinic
#22
JOURNAL ARTICLE
Rahavi Gnanasegar, Wendy Wolfman, Leticia Hernandez Galan, Amie Cullimore, Alison K Shea
OBJECTIVE: Depressive symptoms are commonly reported during the perimenopause and in the early postmenopausal years. Although menopausal hormone therapy (MHT) is considered the most effective treatment option for vasomotor symptoms, its effect on mood-related symptoms is less established. This study aims to assess interval change in depressive symptoms after initiation of MHT treatment in women seeking care at a Canadian specialized menopause clinic. METHODS: Women and female-presenting people attending the St...
February 20, 2024: Menopause: the Journal of the North American Menopause Society
https://read.qxmd.com/read/38352338/perceived-association-of-mood-and-symptom-severity-in-adults-with-mitochondrial-diseases
#23
Catherine Kelly, Alex Junker, Kris Englestad, Michio Hirano, Caroline Trumpff, Martin Picard
Individuals with genetic mitochondrial diseases suffer from multisystemic symptoms that vary in severity from day-to-day and week-to-week, but the underlying causes of symptomatic fluctuations are not understood. Based upon observations that: i) patients and their families frequently report that stressful life events either trigger exacerbations of existing symptoms or the onset of new symptoms, ii) psychological states and stress hormones influence mitochondrial energy production capacity, and iii) epidemiological reports document a robust connection between traumatic/stressful life events and various neurologic disorders, we hypothesized that mitochondrial disease symptom severity may vary according to participant's mood...
February 4, 2024: medRxiv
https://read.qxmd.com/read/38348641/ghrelin-and-depressive-symptoms-in-patients-with-first-episode-drug-na%C3%A3-ve-major-depressive-disorder-the-mediating-role-of-hypothalamic-pituitary-adrenal-axis
#24
JOURNAL ARTICLE
Chuhao Zhang, Yeqing Dong, ShuHua Li, Meijuan Li, Ying Gao, Yuan Liu, Xueying Liu, Chi Zhou, Jie Li
BACKGROUND: Major depressive disorder (MDD) is one of the global burdens of disease, and its pathogenesis remains unclear. An increasing amount of research indicates that ghrelin regulates mood in patients with MDD. Still, current results are inconsistent, and the mechanisms underlying how ghrelin modulates depressive symptoms are inconclusive, especially in first-episode drug-naïve MDD patients. Therefore, this study aims to investigate the relationship and potential mechanism between ghrelin and first-episode drug-naïve MDD...
March 2024: Asia-Pacific Psychiatry: Official Journal of the Pacific Rim College of Psychiatrists
https://read.qxmd.com/read/38339042/the-lack-of-trpa1-ion-channel-does-not-affect-the-chronic-stress-induced-activation-of-the-locus-ceruleus
#25
JOURNAL ARTICLE
Milica Milicic, Balázs Gaszner, Gergely Berta, Erika Pintér, Viktória Kormos
We have previously proven the involvement of transient receptor potential ankyrin 1 (TRPA1) in stress adaptation. A lack of TRPA1 affects both urocortin 1 (member of the corticotropin-releasing hormone (CRH) family) content of the Edinger-Westphal nucleus. The noradrenergic locus ceruleus (LC) is also an important player in mood control. We aimed at investigating whether the TRPA1 is expressed in the LC, and to test if the response to chronic variable mild stress (CVMS) is affected by a lack of TRPA1. The TRPA1 expression was examined via RNAscope in situ hybridization...
February 1, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38338878/observational-study-on-a-large-italian-population-with-lipedema-biochemical-and-hormonal-profile-anatomical-and-clinical-evaluation-self-reported-history
#26
JOURNAL ARTICLE
Laura Patton, Lorenzo Ricolfi, Micaela Bortolon, Guido Gabriele, Pierluigi Zolesio, Erika Cione, Roberto Cannataro
We analyzed the medical condition of 360 women affected by lipedema of the lower limbs in stages 1, 2, and 3. The data were assessed for the whole population and compared between different clinical stages, distinguishing between obese and non-obese patients. The most frequent clinical signs were pain when pinching the skin, subcutaneous nodules, and patellar fat pads. The most frequently painful site of the lower limbs was the medial lower third of the thigh. The pain score obtained on lower limb points increased progressively with the clinical stage...
January 27, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38336466/a-systematic-review-and-critical-appraisal-of-menopause-guidelines
#27
JOURNAL ARTICLE
Chandima Hemachandra, Sasha Taylor, Rakibul M Islam, Ensieh Fooladi, Susan R Davis
OBJECTIVE AND RATIONALE: To identify and appraise current national and international clinical menopause guidance documents, and to extract and compare the recommendations of the most robust examples. DESIGN: Systematic review. DATA SOURCES: Ovid MEDLINE, EMBASE, PsycINFO and Web of Science ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Practice guidance documents for menopause published from 2015 until 20 July 2023. Quality was assessed by the Appraisal of Guidelines for Research and Evaluation II (AGREE II) instrument...
February 9, 2024: BMJ Sexual & Reproductive Health
https://read.qxmd.com/read/38329153/does-a-program-based-cognitive-behavioral-therapy-affect-insomnia-and-depression-in-menopausal-women-a-randomized-controlled-trial
#28
JOURNAL ARTICLE
Ahmed Hashem El-Monshed, Leena Mohamed Khonji, Marwan Altheeb, Moustafa Tag El-Melook Saad, Mahmoud Ahmed Elsheikh, Ahmed Loutfy, Ahmed Salah Ali, Heba E El-Gazar, Sara Mohamed Fayed, Mohamed A Zoromba
BACKGROUND: Menopausal women often complain of a range of physical and psychological symptoms known as menopausal syndrome. These symptoms are associated with fluctuating hormone levels, sleep disturbances, and mood swings. AIM: This study aimed to examine the efficacy of a program-based cognitive behavioral group therapy (CBT) for insomnia and depression among women experiencing menopause. METHODS: A randomized controlled trial of 88 women experiencing menopause was conducted in Egypt from June to September 2022 in outpatient clinics at Mansoura University Hospitals in Egypt...
February 8, 2024: Worldviews on Evidence-based Nursing
https://read.qxmd.com/read/38319916/patterns-of-perioperative-hormone-therapy-for-gender-affirming-surgery
#29
JOURNAL ARTICLE
Ya-Ching Hung, Patrick E Assi, Benjamin C Park, Sriya V Nemani, Sara C Chaker, Teja D Williams, Brian C Drolet, Salam A Kassis
INTRODUCTION: There is no consensus regarding perioperative hormone replacement therapy (HRT) for gender-affirming surgery (GAS). Common concerns for continuing perioperative HRT included risk of deep vein thrombosis (DVT) or hematoma. However, discontinuing HRT is not risk free and may cause mood swing or increased anxiety. Our study aimed to investigate current patterns of HRT before GAS worldwide. METHODS: The first stage of Delphi technique was implemented by sending a 27-item survey to all surgeons (total n = 150; 94 plastic surgeon, 35 urologist, and 21 gynecologists) of the World Professional Association for Transgender Health who perform GAS...
January 25, 2024: Annals of Plastic Surgery
https://read.qxmd.com/read/38318398/a-review-of-the-pharmacology-clinical-outcomes-and-real-world-effectiveness-safety-and-non-contraceptive-effects-of-nomac-e2
#30
REVIEW
Franca Fruzzetti, Rogerio Bonassi Machado, Iñaki Lete, Amisha Patel, Mitra Boolell
Selecting an appropriate oral contraceptive can be challenging for healthcare professionals due to the abundance of marketed contraceptive options with different clinical and real-world effectiveness and safety profiles. Nomegestrol acetate + 17β-estradiol (NOMAC/E2) is a combined oral contraceptive (COC) that inhibits ovulation by suppressing ovarian function by a 17-hydroxy-progesterone derivative and an estrogen identical to that endogenously produced by the ovaries. This narrative review examines clinical and real-world studies of NOMAC/E2 based on a background literature search using PubMed and Google Scholar...
March 2024: European journal of obstetrics & gynecology and reproductive biology: X
https://read.qxmd.com/read/38304304/menstrual-symptoms-and-subjective-well-being-among-postmenarchal-adolescents
#31
JOURNAL ARTICLE
Pietro Gambadauro, Gergö Hadlaczky, Danuta Wasserman, Vladimir Carli
BACKGROUND: Menstrual symptoms are predominantly studied among adults but may occur directly after menarche. Adolescent menstrual healthcare, however, faces specific obstacles and more research into menstrual symptoms as a determinant of adolescent well-being is therefore advocated. OBJECTIVE: This study aimed to investigate menstrual symptoms and their impact on everyday life and well-being among postmenarchal adolescents. STUDY DESIGN: A survey was delivered to a random sample of 1644 schoolgirls, drawn from a population-based project involving 116 lower secondary education schools (7th and 8th grade) in Stockholm, Sweden...
February 2024: AJOG global reports
https://read.qxmd.com/read/38295626/white-matter-volume-and-treatment-with-selective-progesterone-receptor-modulator-in-patients-with-premenstrual-dysphoric-disorder
#32
JOURNAL ARTICLE
Elisavet Kaltsouni, Johan Wikström, Rupert Lanzenberger, Inger Sundström-Poromaa, Erika Comasco
Premenstrual dysphoric disorder (PMDD) is a mood disorder for which selective progesterone receptor modulator (SPRM) treatment has been demonstrated to be beneficial. The neural signatures of this treatment have been so far identified as greater fronto-cingulate reactivity during aggressive response to provocation, but no changes in terms of gray matter structure. White matter has recently been found to differ between patients with PMDD and healthy controls. The present study thus sought to investigate the relationship between white matter volume and SPRM treatment in patients with PMDD...
January 22, 2024: Psychoneuroendocrinology
https://read.qxmd.com/read/38292640/addison-s-disease-caused-by-adrenal-tuberculosis-may-lead-to-misdiagnosis-of-major-depressive-disorder-a-case-report
#33
Tian-Xiang Zhang, Hong-Yan Xu, Wei Ma, Jian-Bao Zheng
BACKGROUND: Addison's disease (AD) is a rare but potentially fatal disease in Western countries, which can easily be misdiagnosed at an early stage. Severe adrenal tuberculosis (TB) may lead to depression in patients. CASE SUMMARY: We report a case of primary adrenal insufficiency secondary to adrenal TB with TB in the lungs and skin in a 48-year-old woman. The patient was misdiagnosed with depression because of her depressed mood. She had hyperpigmentation of the skin, nails, mouth, and lips...
January 6, 2024: World Journal of Clinical Cases
https://read.qxmd.com/read/38284220/is-trait-rumination-associated-with-affective-reactivity-to-the-menstrual-cycle-a-prospective-analysis
#34
JOURNAL ARTICLE
Hafsah A Tauseef, Katja M Schmalenberger, Jordan C Barone, Jaclyn M Ross, Jessica R Peters, Susan S Girdler, Tory A Eisenlohr-Moul
BACKGROUND: A minority of naturally cycling individuals experience clinically significant affective changes across the menstrual cycle. However, few studies have examined cognitive and behavioral constructs that may maintain or worsen these changes. Several small studies link rumination with premenstrual negative affect, with authors concluding that a tendency to ruminate amplifies and perpetuates hormone-sensitive affective symptoms. Replication in larger samples is needed to confirm the validity of rumination as a treatment target...
January 29, 2024: Psychological Medicine
https://read.qxmd.com/read/38263257/progesterone-receptor-distribution-in-the-human-hypothalamus-and-its-association-with-suicide
#35
JOURNAL ARTICLE
Lin Zhang, Ronald W H Verwer, Joop van Heerikhuize, Paul J Lucassen, Peter W Nathanielsz, Elly M Hol, Eleonora Aronica, Waljit S Dhillo, Gerben Meynen, Dick F Swaab
The human hypothalamus modulates mental health by balancing interactions between hormonal fluctuations and stress responses. Stress-induced progesterone release activates progesterone receptors (PR) in the human brain and triggers alterations in neuropeptides/neurotransmitters. As recent epidemiological studies have associated peripheral progesterone levels with suicide risks in humans, we mapped PR distribution in the human hypothalamus in relation to age and sex and characterized its (co-) expression in specific cell types...
January 23, 2024: Acta Neuropathologica Communications
https://read.qxmd.com/read/38256338/androgen-deprivation-therapy-for-prostate-cancer-focus-on-cognitive-function-and-mood
#36
REVIEW
Allison B Reiss, Shelly Gulkarov, Aaron Pinkhasov, Katie M Sheehan, Ankita Srivastava, Joshua De Leon, Aaron E Katz
Prostate cancer is the second leading cause of cancer death in men in the United States. Androgen deprivation therapy (ADT) is currently the primary treatment for metastatic prostate cancer, and some studies have shown that the use of anti-androgen drugs is related to a reduction in cognitive function, mood changes, diminished quality of life, dementia, and possibly Alzheimer's disease. ADT has potential physiological effects such as a reduction in white matter integrity and a negative impact on hypothalamic functions due to the lowering of testosterone levels or the blockade of downstream androgen receptor signaling by first- and second-generation anti-androgen drugs...
December 30, 2023: Medicina
https://read.qxmd.com/read/38255937/targeting-human-glucocorticoid-receptors-in-fear-learning-a-multiscale-integrated-approach-to-study-functional-connectivity
#37
REVIEW
Simone Battaglia, Chiara Di Fazio, Matteo Mazzà, Marco Tamietto, Alessio Avenanti
Fear extinction is a phenomenon that involves a gradual reduction in conditioned fear responses through repeated exposure to fear-inducing cues. Functional brain connectivity assessments, such as functional magnetic resonance imaging (fMRI), provide valuable insights into how brain regions communicate during these processes. Stress, a ubiquitous aspect of life, influences fear learning and extinction by changing the activity of the amygdala, prefrontal cortex, and hippocampus, leading to enhanced fear responses and/or impaired extinction...
January 10, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38255692/effects-of-physical-exercise-and-motor-activity-on-depression-and-anxiety-in-post-mastectomy-pain-syndrome
#38
JOURNAL ARTICLE
Marco Calapai, Luisa Puzzo, Giuseppe Bova, Daniele Alfio Vecchio, Rosario Blandino, Alessia Barbagallo, Ilaria Ammendolia, Luigi Cardia, Fabrizio Calapai, Mariaconcetta Currò, Giovanni Ficarra, Emanuela Esposito, Fabio Trimarchi, Debora Di Mauro, Gioacchino Calapai, Carmen Mannucci
BACKGROUND: Chronic post-surgical pain is a condition persisting for not less than 3 months after surgical intervention. It is evaluated that 25-60% of women who underwent breast cancer excision suffer from post-mastectomy pain syndrome, and anxiety, depression, sleep disturbance, and catastrophizing. Physical activity can reduce the risk of chronic diseases and has a good impact on mood and cognitive function. The aim of this study was to estimate the influence of physical activity on the intensity of pain, depression, and anxiety in women who underwent mastectomy for breast cancer removal...
January 2, 2024: Life
https://read.qxmd.com/read/38253240/neuroendocrine-mechanisms-in-the-links-between-early-life-stress-affect-and-youth-substance-use-a-conceptual-model-for-the-study-of-sex-and-gender-differences
#39
REVIEW
Alexandra Donovan, Shervin Assari, Christine Grella, Magda Shaheen, Linda Richter, Theodore C Friedman
Early life stress (ELS) is defined as an acute or chronic stressor that negatively impacts a child's development. ELS is associated with substance use and mental health problems. This narrative literature review focuses on sex and gender differences in the effects of ELS on 1) adolescent neuroendocrine development; 2) pubertal brain maturation; and 3) development of internalizing symptoms and subsequent substance use. We posit that ELS may generate larger hormonal dysregulation in females than males during puberty, increasing internalizing symptoms and substance use...
January 20, 2024: Frontiers in Neuroendocrinology
https://read.qxmd.com/read/38251874/obesity-and-sexual-health-focus-on-postmenopausal-women
#40
REVIEW
F Barbagallo, L Cucinella, L Tiranini, P Chedraui, A E Calogero, R E Nappi
Menopause is a cardiometabolic transition with many women experiencing weight gain and redistribution of body fat. Hormonal changes may affect also several dimensions of well-being, including sexual function, with a high rate of female sexual dysfunction (FSD), which displays a multifactorial etiology. The most important biological factors range from chronic low-grade inflammation, associated with hypertrophic adipocytes that may translate into endothelial dysfunction and compromised blood flow through the genitourinary system, to insulin resistance and other neuroendocrine mechanisms targeting the sexual response...
January 22, 2024: Climacteric: the Journal of the International Menopause Society
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