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Hormones and mood

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https://www.readbyqxmd.com/read/29138210/what-happens-after-menopause-wham-protocol-for-a-prospective-multicentre-age-matched-cohort-trial-of-risk-reducing-bilateral-salpingo-oophorectomy-in-high-risk-premenopausal-women
#1
Martha Hickey, Alison Trainer, Sabine Braat, Mary-Ann Davey, Efrosinia Krejany, John Wark
INTRODUCTION: Women at high inherited risk of ovarian cancer are advised to undergo risk-reducing bilateral salpingo-oophorectomy (RRBSO) at age 40-45 years or when their families are complete. Most women are premenopausal at this age, so RRBSO will induce surgical menopause. Despite the clear benefits of RRBSO for cancer risk reduction, much less is known about the impact on non-cancer outcomes that contribute to health and well-being and inform surveillance and management strategies...
November 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/29110974/the-psychoneuroimmunology-of-pregnancy
#2
Morgan L Sherer, Caitlin K Posillico, Jaclyn M Schwarz
Pregnancy is associated with a number of significant changes in maternal physiology. Perhaps one of the more notable changes is the significant alteration in immune function that occurs during pregnancy. This change in immune function is necessary to support a successful pregnancy, but also creates a unique period of life during which a female is susceptible to disease and, as we'll speculate here, may also contribute to mental health disorders associated with pregnancy and the postpartum period. Here, we review the known changes in peripheral immune function that occur during pregnancy and the postpartum period, while highlighting the impact of hormones during these times on immune function, brain or neural function, as well as behavior...
October 27, 2017: Frontiers in Neuroendocrinology
https://www.readbyqxmd.com/read/29095270/pituitary-insufficiency-following-traumatic-thoracic-injury-in-an-adolescent-male-patient-a-case-report-and-literature-review
#3
REVIEW
Aleksandra Gilis-Januszewska, Łukasz Kluczyński, Małgorzata Wilusz, Jacek Pantofliński, Renata Turek-Jabrocka, Dorota Pach, Alicja Hubalewska-Dydejczyk
RATIONALE: Traumatic thoracic injuries in adolescents are rare but could be connected with traumatic brain injuries (TBI) and development of chronic hypopituitarism. Early recognition of these endocrine problems is a significant challenge to clinicians. We present difficulties in diagnosis of hypothalamic-pituitary insufficiency following traumatic thoracic injury in adolescence. We also review the literature of similar cases. PATIENT CONCERNS: We present a case of a 24-years-old male...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29079741/combined-x-ray-crystallography-and-computational-modeling-approach-to-investigate-the-hsp90-c-terminal-peptide-binding-to-fkbp51
#4
Rajnish Kumar, Martin Moche, Bengt Winblad, Pavel F Pavlov
FK506 binding protein of 51 kDa (FKBP51) is a heat shock protein 90 (Hsp90) co-chaperone involved in the regulation of steroid hormone receptors activity. It is known for its role in various regulatory pathways implicated in mood and stress-related disorders, cancer, obesity, Alzheimer's disease and corticosteroid resistant asthma. It consists of two FKBP12 like active peptidyl prolyl isomerase (PPIase) domains (an active FK1 and inactive FK2 domain) and one tetratricopeptide repeat (TPR) domain that mediates interaction with Hsp90 via its C-terminal MEEVD peptide...
October 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29057204/shift-work-disrupted-circadian-rhythms-and-sleep-implications-for-health-and-well-being
#5
Stephen M James, Kimberly A Honn, Shobhan Gaddameedhi, Hans P A Van Dongen
PURPOSE OF REVIEW: Our 24/7 society is dependent on shift work, despite mounting evidence for negative health outcomes from sleep displacement due to shift work. This paper reviews short- and long-term health consequences of sleep displacement and circadian misalignment due to shift work. RECENT FINDINGS: We focus on four broad health domains: metabolic health; risk of cancer; cardiovascular health; and mental health. Circadian misalignment affects these domains by inducing sleep deficiency, sympathovagal and hormonal imbalance, inflammation, impaired glucose metabolism, and dysregulated cell cycles...
June 2017: Current Sleep Medicine Reports
https://www.readbyqxmd.com/read/29048182/differences-in-mood-and-cortisol-by-menstrual-phase-during-acute-smoking-abstinence-a-within-subject-comparison
#6
Samantha C Carlson, Alicia M Allen, Sharon S Allen, Mustafa al'Absi
There is evidence that smoking-cessation success differs by menstrual phase and sex hormone levels; however, the biological mechanisms underlying these differences are not clear. One possibility is that variation in cortisol throughout the menstrual cycle and early smoking abstinence may be partly responsible. The goal of this secondary-data analysis was to conduct a within-subject examination of the effects of menstrual phase and smoking abstinence on salivary cortisol and mood. Data are from a controlled crossover trial, in which participants completed 2 testing weeks during their follicular and luteal phases...
October 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29027807/biochemistry-of-the-menopause
#7
John W Honour
The life of a human female is characterized from teenage years by monthly menstruation which ceases (the menopause) typically between the age of 40 and 60 years. The potential for reproduction declines and ceases as the ovaries become depleted of follicles. A transition period in mid-life, for 2 to 10 years, when menstruation is less regular is called the perimenopause. The menopause is associated with a significant decline in plasma concentrations of sex hormones, an increase in the concentrations of the gonadotrophins and changes in other hormones such as the inhibins...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29023546/steroid-hormones-and-psychological-responses-to-soccer-matches-insights-from-a-systematic-review-and-meta-analysis
#8
REVIEW
Maamer Slimani, Julien S Baker, Foued Cheour, Lee Taylor, Nicola Luigi Bragazzi
The present systematic review and meta-analysis aimed to assess the perturbations in hormonal and psychological homeostasis in response to soccer match-play. These perturbations were explored according to match outcome (i.e., win versus loss), gender, type of contest (i.e., competitive versus non-competitive fixtures) and competitive level (i.e., novice versus high-level). The review was conducted according to the Population/Intervention or Exposure/Comparison/Outcome(s) (PICO) criteria and the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines...
2017: PloS One
https://www.readbyqxmd.com/read/29023380/the-gut-microbiome-feelings-of-the-brain-a-perspective-for-non-microbiologists
#9
REVIEW
Aaron Lerner, Sandra Neidhöfer, Torsten Matthias
Objectives: To comprehensively review the scientific knowledge on the gut-brain axis. Methods: Various publications on the gut-brain axis, until 31 July 2017, were screened using the Medline, Google, and Cochrane Library databases. The search was performed using the following keywords: "gut-brain axis", "gut-microbiota-brain axis", "nutrition microbiome/microbiota", "enteric nervous system", "enteric glial cells/network", "gut-brain pathways", "microbiome immune system", "microbiome neuroendocrine system" and "intestinal/gut/enteric neuropeptides"...
October 12, 2017: Microorganisms
https://www.readbyqxmd.com/read/29022126/a-systematic-review-of-cortisol-thyroid-stimulating-hormone-and-prolactin-in-peripartum-women-with-major-depression
#10
REVIEW
Mercedes J Szpunar, Barbara L Parry
Pregnancy and postpartum are periods of high susceptibility to major depression (MD) and other mood disorders. The peripartum period is also a time of considerable changes in the levels of hormones, including cortisol, thyroid-stimulating hormone (TSH), prolactin, gonadotropins, and gonadal steroids. To investigate the relationship between mood and hormonal changes during and after pregnancy, we reviewed published reports of hormonal measures during this time frame, searched via PubMed and Web of Science. Studies were included if women in the antepartum or postpartum periods were clinically diagnosed with MD, and if there were repeated measures of cortisol, TSH, or prolactin...
October 11, 2017: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/29021759/effects-of-gladiolus-dalenii-on-the-stress-induced-behavioral-neurochemical-and-reproductive-changes-in-rats
#11
David Fotsing, Gwladys T Ngoupaye, Agnes C Ouafo, Stephanie K J Njapdounke, Yongabi A Kenneth, Elisabeth Ngo Bum
Gladiolus dalenii is a plant commonly used in many regions of Cameroon as a cure for various diseases like headaches, epilepsy, schizophrenia, and mood disorders. Recent studies have revealed that the aqueous extract of G. dalenii (AEGD) exhibited antidepressant-like properties in rats. Therefore, we hypothesized that the AEGD could protect from the stress-induced behavioral, neurochemical, and reproductive changes in rats. The objective of the present study was to elucidate the effect of the AEGD on behavioral, neurochemical, and reproductive characteristics, using female rats subjected to chronic immobilization stress...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28992710/-male-hypogonadism-and-its-treatment
#12
Václav Hána, Mikuláš Kosák, Václav Hána
Male hypogonadism can be of various etiology and that reflects its clinical manifestation, diagnostics and treatment. Male hypogonadism leads not only to decreased fertility, but influences the cardiovascular system, mood changes, bone fragility, lipids and other metabolic functions. Diagnosis of hypogonadism can be cumbersome, as well as the choice of optimal hormonal supplementation. The aim of this article is to summarize the basics from symptoms, diagnosis and treatment of male hypogonadism.
2017: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/28991767/anorexia-anormal-phobia-of-normal-weight
#13
Nada Pop-Jordanova, Tatjana Zorcec, Aneta Demerdzieva
Anorexia nervosa is a disorder of feeding behavior associated with distortion of body image, mood disturbance and a wide variety of hormonal and metabolic abnormalities. It is supposed that the disease could be the consequence of a combination of cultural-social, psychological and biological factors. Our study confirmed that anorexia mentalis is a serious, life threatening disorder which in our country appears earlier than it was expected and that is strongly related to environmental factors (family, school, fashion, society)...
September 1, 2017: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/28987626/no-involvement-in-the-inhibition-of-ghrelin-on-voltage-dependent-potassium-currents-in-rat-hippocampal-cells
#14
Yong Lu, Shaokang Dang, Xu Wang, Junli Zhang, Lin Zhang, Qian Su, Huiping Zhang, Tianwei Lin, Xiaoxiao Zhang, Yurong Zhang, Hongli Sun, Zhongliang Zhu, Hui Li
Ghrelin is a peptide hormone that plays an important role in promoting appetite, regulating distribution and rate of use of energy, cognition, and mood disorders, but the relevant neural mechanisms of these function are still not clear. In this study, we examined the effect of ghrelin on voltage-dependent potassium (K(+)) currents in hippocampal cells of 1-3 days SD rats by whole-cell patch-clamp technique, and discussed whether NO was involved in this process. The results showed that ghrelin significantly inhibited the voltage-dependent K(+) currents in hippocampal cells, and the inhibitory effect was more significant when L-arginine was co-administered...
October 4, 2017: Brain Research
https://www.readbyqxmd.com/read/28982486/weight-gain-in-women-at-midlife-a-concise-review-of-the-pathophysiology-and-strategies-for-management
#15
REVIEW
Ekta Kapoor, Maria L Collazo-Clavell, Stephanie S Faubion
Weight gain accompanied by an increased tendency for central fat distribution is common among women in midlife. These changes are a result of aging, decreasing estrogen levels after menopause, and other unique influences in menopausal women that interfere with the adoption of healthy lifestyle measures. Central obesity, in particular, results in several adverse metabolic consequences, including dysglycemia, dyslipidemia, hypertension, and cardiovascular disease. Given that cardiovascular disease is the leading cause of death in postmenopausal women, the importance of weight management in midlife cannot be overemphasized...
October 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28979126/depression-and-family-support-in-breast-cancer-patients
#16
Jian-An Su, Dah-Cherng Yeh, Ching-Chi Chang, Tzu-Chin Lin, Ching-Hsiang Lai, Pei-Yun Hu, Yi-Feng Ho, Vincent Chin-Hung Chen, Tsu-Nai Wang, Michael Gossop
BACKGROUND: Breast cancer is the most common cancer in women. Among the survivors, depression is one of the most common psychiatric comorbidities. This paper reports the point prevalence of major depressive disorder among breast cancer patients and the association between family support and major depressive disorder. METHODS: Clinical data were collected from a breast cancer clinic of a general hospital in central Taiwan. Participants included 300 patients who were older than 18 years and diagnosed with breast cancer...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28971444/correlations-between-nutrition-habits-anxiety-and-metabolic-parameters-in-greek-healthy-adults
#17
Stavroula Lambrinakou, Maria Efthymia Katsa, Sofia Zyga, Anastasios Ioannidis, Athanasios Sachlas, Georgios Panoutsopoulos, Anna Maria Pistikou, Maria Magana, Dafni Eleni Kougioumtzi Dimoligianni, Petros Kolovos, Andrea Paola Rojas Gil
BACKGROUND: Anxiety combined with nervousness and apprehension consist a focal response to different life conditions. Lifestyle habits, anxiety and biochemical markers are in a constant interaction. AIM: To investigate the prevalence of anxiety in healthy adults and its possible association with biochemical factors-lipid profile, liver markers, thyroid hormones-and lifestyle habits. METHODS: Quantitative descriptive correlation study. A total of 100 healthy adults participated in the research...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28967098/epigenetic-regulation-of-melatonin-receptors-in-neuropsychiatric-disorders
#18
REVIEW
Sarra G Bahna, Lennard P Niles
Melatonin, the primary indoleamine hormone of the mammalian pineal gland, is known to have a plethora of neuroregulatory, neuroprotective and other properties. Melatonergic signaling is mediated by its two G protein-coupled receptors, MT1 and MT2 , which are widely expressed in the mammalian CNS. Melatonin levels and receptor expression often show a decrease during normal aging, and this reduction may be accelerated in some disease states. Depleted melatonergic signaling has been associated with neuropsychiatric dysfunction and impairments in cognition, memory, neurogenesis and neurorestorative processes...
October 2, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28966733/sleep-melatonin-and-the-menopausal-transition-what-are-the-links
#19
Shazia Jehan, Giardin Jean-Louis, Ferdinand Zizi, Evan Auguste, Seitikurippu R Pandi-Perumal, Ravi Gupta, Hrayr Attarian, Samy I McFarlane, Rüdiger Hardeland, Amnon Brzezinski
The pineal hormone Melatonin plays an important role in the regulation of the circadian sleep/wake cycle, mood, and perhaps immune functions, carcinogensis and reproduction. The human circadian rhythm of melatonin release from the pineal gland is tightly synchronized with the habitual hours of sleep. Peri- and postmenopausal women often complain of difficulties initiating and/or maintaining sleep, with frequent nocturnal and early morning awakenings. In this review we discuss the pathophysiology of melatonin function as it relates to sleep disorders in menopausal women, highlighting the potential use of exogenous melatonin during the menopausal transition and beyond...
January 2017: Sleep Science
https://www.readbyqxmd.com/read/28953796/the-magic-of-caressing-the-mind-by-touching-the-body-take-care-of-depression-face-up-to-cancer-a-new-frontier-of-psycho-oncology
#20
Maria Grazia Spurio
BACKGROUND: The new frontier of research in all areas that deal with health and wellness (medicine, psychotherapy, personal care in general) sees the increase of projects in which the individual is center-placed, as a whole, in a holistic view. The mind and the body are inseparable, as in a circularity and recursivity unique for each individual (Spurio, M.G., 2015). The results of the most innovative research would seem to suggest, therefore, that a state of psychological distress or depression, is often related to physiological problems, from physical discomfort in general up to illnesses such as cancer...
September 2017: Psychiatria Danubina
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