keyword
https://read.qxmd.com/read/38490912/clinical-and-sociodemographic-characteristics-as-predictors-for-quality-of-life-in-transmasculine-and-transfeminine-individuals-receiving-gender-affirming-hormone-therapy
#1
JOURNAL ARTICLE
Saloni U Lad, Jacob Sinopoli, Brian Khong, Britt Conroy, Adam T Perzynski, Juan P Del Rincon
Healthcare systems and providers have increasingly acknowledged the role and impact of social determinants in overall health. However, gender-diverse individuals face persistent health disparities due to their identities. There is limited research on the impact of clinical and sociodemographic characteristics on mood and quality of life (QoL) for transgender (TG) individuals. Our study aims to understand and better elucidate social and clinical characteristics of transmasculine (TM) and transfeminine (TF) individuals and their impact on quality of life and depressive symptoms...
March 7, 2024: Social Science & Medicine
https://read.qxmd.com/read/38489380/photo-neuro-immuno-endocrinology-how-the-ultraviolet-radiation-regulates-the-body-brain-and-immune-system
#2
JOURNAL ARTICLE
Radomir M Slominski, Jake Y Chen, Chander Raman, Andrzej T Slominski
Ultraviolet radiation (UVR) is primarily recognized for its detrimental effects such as cancerogenesis, skin aging, eye damage, and autoimmune disorders. With exception of ultraviolet B (UVB) requirement in the production of vitamin D3, the positive role of UVR in modulation of homeostasis is underappreciated. Skin exposure to UVR triggers local responses secondary to the induction of chemical, hormonal, immune, and neural signals that are defined by the chromophores and extent of UVR penetration into skin compartments...
April 2, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38482310/case-report-contraceptive-implant-migration
#3
Sahar M Alotaibi, Mohammed L Al-Otaibi
Subdermal contraceptive implants are one of the effective and reversible methods of contraception available today. Implanon is a Saudi FDA-approved contraceptive that is commonly used by the Saudi population. Along with their hormonal side effects such as mood changes and acne, subdermal contraceptive implants can also lead to more life-threatening, albeit rare, mishaps, such as the deeper migration of them into the axillary and thoracic structures. Only a few cases exist in the literature regarding these rare complications...
January 2024: Journal of Family Medicine and Primary Care
https://read.qxmd.com/read/38481111/decision-regret-following-the-choice-of-surgery-or-active-surveillance-for-small-low-risk-papillary-thyroid-cancer-a-prospective-cohort-study
#4
JOURNAL ARTICLE
Anna M Sawka, Sangeet Ghai, Lorne Rotstein, Jonathan C Irish, Jesse D Pasternak, Eric Monteiro, Janet Chung, Afshan Zahedi, Jie Su, Wei Xu, Jennifer Jones, Amiram Gafni, Nancy Baxter, David P Goldstein
BACKGROUND: It is important to understand cancer survivors' perceptions about their treatment decisions and quality of life. METHODS: We performed a prospective observational cohort study of Canadian patients with small (< 2cm) low risk papillary thyroid cancer who were offered the choice of active surveillance (AS) or surgery (Clinicaltrials.gov NCT03271892). Participants completed a questionnaire one year after their treatment decision. The primary intention-to-treat analysis compared the mean decision regret scale total score between patients who chose AS or surgery...
March 13, 2024: Thyroid: Official Journal of the American Thyroid Association
https://read.qxmd.com/read/38479478/the-underlying-roles-and-neurobiological-mechanisms-of-music-based-intervention-in-alzheimer-s-disease-a-comprehensive-review
#5
REVIEW
Liyang Sun, Qin Wang, Jing Ai
Non-pharmacological therapy has gained popularity in the intervention of Alzheimer's disease (AD) due to its apparent therapeutic effectiveness and the limitation of biological drug. A wealth of research indicates that music interventions can enhance cognition, mood and behavior in individuals with AD. Nonetheless, the underlying mechanisms behind these improvements have yet to be fully and systematically delineated. This review aims to holistically review how music-based intervention (MBI) ameliorates abnormal emotion, cognition decline, and behavioral changes in AD patients...
March 11, 2024: Ageing Research Reviews
https://read.qxmd.com/read/38469966/modest-effects-of-neurofeedback-assisted-meditation-using-a-wearable-device-on-stress-reduction-a-randomized-double-blind-and-controlled-study
#6
JOURNAL ARTICLE
Eunyoung Lee, Jung Kyung Hong, Hayun Choi, In-Young Yoon
BACKGROUND: To evaluate the therapeutic effectiveness and safety of a neurofeedback wearable device for stress reduction. METHODS: A randomized, double-blind, controlled study was designed. Participants had psychological stress with depression or sleep disturbances. They practiced either neurofeedback-assisted meditation (n = 20; female, 15 [75.0%]; age, 49.40 ± 11.76 years) or neurofeedback non-assisted meditation (n = 18; female, 11 [61.1%]; age, 48.67 ± 12...
March 11, 2024: Journal of Korean Medical Science
https://read.qxmd.com/read/38464534/neuronal-ablation-of-ghsr-mitigates-diet-induced-depression-and-memory-impairment-via-ampk-autophagy-signaling-mediated-inflammation
#7
JOURNAL ARTICLE
Hongying Wang, Zheng Shen, Chia-Shan Wu, Pengfei Ji, Ji Yeon Noh, Cédric G Geoffroy, Sunja Kim, David Threadgill, Jianrong Li, Yu Zhou, Xiaoqiu Xiao, Hui Zheng, Yuxiang Sun
Obesity is associated with chronic inflammation in the central nervous system (CNS), and neuroinflammation has been shown to have detrimental effects on mood and cognition. The growth hormone secretagogue receptor (GHSR), the biologically relevant receptor of the orexigenic hormone ghrelin, is primarily expressed in the brain. Our previous study showed that neuronal GHSR deletion prevents high-fat diet-induced obesity (DIO). Here, we investigated the effect of neuronal GHSR deletion on emotional and cognitive functions in DIO...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38459552/effects-of-depot-medroxyprogesterone-acetate-the-copper-iud-and-the-levonorgestrel-implant-on-testosterone-sex-hormone-binding-globulin-and-free-testosterone-levels-ancillary-study-of-the-echo-randomized-clinical-trial
#8
JOURNAL ARTICLE
G Justus Hofmeyr, Mandisa Singata-Madliki, Joanne Batting, Yusentha Balakrishna, Chelsea Morroni
BACKGROUND: Robust information on relative effects of hormonal contraceptives on endogenous androgens is important for understanding beneficial and adverse effects, method choice and development of new methods. METHODS: In this ancillary study at the East London, South Africa site of the ECHO multicentre randomized trial, we compared effects of three contraceptive methods on serum androgen levels among contraceptive users aged 18 to 35 years. Participants were allocated by centrally-managed randomization to open label depot medroxyprogesterone acetate (DMPA-IM), copper intrauterine device (IUD) or levonorgestrel implant...
March 8, 2024: BMC Women's Health
https://read.qxmd.com/read/38459484/the-effect-of-lavender-on-mood-disorders-associated-with-the-use-of-combined-oral-contraceptives-cocs-a-triple-blinded-randomized-controlled-trial
#9
JOURNAL ARTICLE
Mina Naghdi, Azizeh Farshbaf-Khalili, Jila Nahaee, Parvin Hakimi, Mahnaz Shahnazi
BACKGROUND: The use of contraceptive methods is influenced by their effectiveness, availability, and minimal side effects. OCPs are one of the most effective and widely used methods of pregnancy prevention worldwide. This method not only prevents pregnancy but also helps prevent and treat other diseases. One of the main reasons for discontinuing this method is the emotional disturbances associated with its use. Lavender is an evergreen, fragrant plant that has gained significant attention for its anti-anxiety effects...
March 8, 2024: BMC complementary medicine and therapies
https://read.qxmd.com/read/38458217/managing-menopause-after-cancer
#10
REVIEW
Martha Hickey, Partha Basu, Jenifer Sassarini, Mariken E Stegmann, Elisabete Weiderpass, Karen Nakawala Chilowa, Cheng-Har Yip, Ann H Partridge, Donal J Brennan
Globally, 9 million women are diagnosed with cancer each year. Breast cancer is the most commonly diagnosed cancer worldwide, followed by colorectal cancer in high-income countries and cervical cancer in low-income countries. Survival from cancer is improving and more women are experiencing long-term effects of cancer treatment, such as premature ovarian insufficiency or early menopause. Managing menopausal symptoms after cancer can be challenging, and more severe than at natural menopause. Menopausal symptoms can extend beyond hot flushes and night sweats (vasomotor symptoms)...
March 9, 2024: Lancet
https://read.qxmd.com/read/38453284/the-relationship-between-biological-rhythm-and-perceived-social-support-coping-styles-and-medication-adherence-in-patients-with-bipolar-disorder-in-t%C3%A3-rkiye
#11
JOURNAL ARTICLE
Tuğçe Uçgun, Emine Öksüz
INTRODUCTION: The disruption of biological rhythm (sleep, eating patterns, hormonal secretions, activities, and social life etc.) in individuals diagnosed with bipolar disorder makes it challenging to balance the mood of the patient and facilitates recurrence. Although social support, coping with stress, and medication adherence are known to affect prognosis, no study has been found to investigate the relationship between these factors and biological rhythm. AIM: This descriptive and correlational design study investigated the relationship between perceived social support, coping styles and medication adherence, and biological rhythm in individuals diagnosed with bipolar disorder...
February 2024: Archives of Psychiatric Nursing
https://read.qxmd.com/read/38442504/mid-pregnancy-allopregnanolone-levels-and-trajectories-of-perinatal-depressive-symptoms
#12
JOURNAL ARTICLE
Richelle D Björväng, Ylva Walldén, Emma Fransson, Erika Comasco, Inger Sundström-Poromaa, Alkistis Skalkidou
Perinatal depression is a major cause of disability for individuals giving birth worldwide, with detrimental effects on short- and long-term parental and child outcomes. There is emerging evidence that the neuroactive steroid hormone allopregnanolone is implicated in the pathophysiology and course of perinatal mood symptoms. However, no study thus far has examined allopregnanolone levels whilst making use of longitudinal data on depressive symptom trajectories throughout the perinatal period. The present study investigated levels of allopregnanolone at gestational week 17 of 252 participants in relation to perinatal depressive symptom trajectories, with a secondary aim of exploring the role of history of depression as an effect modifier...
February 28, 2024: Psychoneuroendocrinology
https://read.qxmd.com/read/38434143/a-fit-for-purpose-validation-of-a-commercial-radioimmunoassay-for-measurement-of-human-peripheral-oxytocin
#13
JOURNAL ARTICLE
Keenan Gerred, Amita Kapoor
Oxytocin (OT) is a peptide hormone synthesized in the hypothalamus and released into systemic circulation or other areas of the brain. Its physiological roles include action as a hormone with stimulation of uterine contractions and that as a neuromodulator with involvement in social behaviors and regulation of mood. Its small size and low levels within biological matrices make it challenging to accurately measure. The goal of this study was to demonstrate the specificity of the antibody, sensitivity, and reproducibility of the Phoenix Pharmaceuticals (PP) OT radioimmunoassay (RIA) for use in human urine, serum, and saliva...
July 2024: Biochemistry and Biophysics Reports
https://read.qxmd.com/read/38426367/an-exploratory-study-of-factors-in-disordered-eating-behavior-in-diabetes-self-management-in-japan
#14
JOURNAL ARTICLE
Sachiko Tsukamoto-Kawashima, Kaori Ikeda, Masakatsu Sone, Masahito Ogura, Emi Okamura, Aki Kondo, Yoko Ueba, Nobuya Inagaki
AIMS/INTRODUCTION: Diet directly affects glucose metabolism, and eating behavior is influenced by various daily life stressors. This study was conducted to investigate the relationship between common psychosomatic stressors on endocrine hormones and eating behavior in patients with type 2 diabetes. MATERIALS AND METHODS: This cross-sectional study was performed in 40 patients with type 2 diabetes. Resting hormone blood sampling and four self-reported questionnaires were employed...
March 1, 2024: Journal of Diabetes Investigation
https://read.qxmd.com/read/38421107/tert-mediates-the-u-shape-of-glucocorticoids-effects-in-modulation-of-hippocampal-neural-stem-cells-and-associated-brain-function
#15
JOURNAL ARTICLE
Meng-Ying Liu, Yixin Fan, Ningjie Ni, Tao Yu, Zhiyuan Mao, Hanyu Huang, Jing Zhang, Yulin Tang, Hongliang He, Fan Meng, Yongping You, Qi-Gang Zhou
BACKGROUND: Glucocorticoids (GCs) are steroidal hormones produced by the adrenal cortex. A physiological-level GCs have a crucial function in maintaining many cognitive processes, like cognition, memory, and mood, however, both insufficient and excessive GCs impair these functions. Although this phenomenon could be explained by the U-shape of GC effects, the underlying mechanisms are still not clear. Therefore, understanding the underlying mechanisms of GCs may provide insight into the treatments for cognitive and mood-related disorders...
February 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38419952/case-report-uncovering-hidden-glucose-patterns-in-medicated-versus-unmedicated-bipolar-disorder-and-comorbid-type-1-diabetes-mellitus
#16
Dagmar Breznoscakova, Maria Pallayova
INTRODUCTION: Type 1 diabetes mellitus is characterized by an absolute insulin deficiency requiring the lifetime intensive insulin therapy accompanied by daily self-monitoring, self-management, ongoing education, and complex diabetes care. Regular patient-clinician shared therapeutic decisions based on age, sex, comorbidities, medications, predicted impact of meals, physical activity, stress, hormonal changes, insulin therapy, and patterns of glycemic changes are key for achieving glycemic targets...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38419452/two-adverse-early-life-events-induce-differential-changes-in-brain-crh-and-serotonin-systems-in-rats-along-with-hyperphagia-and-depression
#17
JOURNAL ARTICLE
Viridiana Alcántara-Alonso, Cinthia García-Luna, Paulina Soberanes-Chávez, Erika Estrada-Camarena, Patricia de Gortari
BACKGROUND: Different types of stress inflicted in early stages of life elevate the risk, among adult animals and humans, to develop disturbed emotional-associated behaviors, such as hyperphagia or depression. Early-life stressed (ELS) adults present hyperactivity of the hypothalamus-pituitary-adrenal (HPA) axis, which is a risk factor associated with mood disorders. However, the prevalence of hyperphagia (17%) and depression (50%) is variable among adults that experienced ELS, suggesting that the nature, intensity, and chronicity of the stress determines the specific behavioral alteration that those individuals develop...
February 20, 2024: Journal of Integrative Neuroscience
https://read.qxmd.com/read/38406773/the-effects-of-vitamin-d-and-calcium-on-primary-dysmenorrhea-a-systematic-review
#18
REVIEW
Ainur Donayeva, Ainur Amanzholkyzy, Ibrahim Abdelazim, Samat Saparbayev, Roza Nurgaliyeva, Aiman Kaldybayeva, Azhar Zhexenova, Gulnara Gubasheva, Dinmukhamed Ayaganov, Ihab Samaha
Dysmenorrhea, affecting approximately 80% of adolescents, significantly impairs quality of life, disrupts sleep patterns, and induces mood changes. Furthermore, its economic impact is substantial, accounting for an estimated $200 billion in the United States and $4.2 million in Japan annually. This review aimed to identify the effects of vitamin D and calcium on primary dysmenorrhea. We conducted a comprehensive literature search across Web of Science, PubMed, Scopus, and Science Direct, focusing on studies published from 2010 to 2020...
November 2023: Journal of Medicine and Life
https://read.qxmd.com/read/38404464/mood-and-microbes-a-comprehensive-review-of-intestinal-microbiota-s-impact-on-depression
#19
REVIEW
Ameer Luqman, Mei He, Adil Hassan, Mehtab Ullah, Liyuan Zhang, Muhammad Rashid Khan, Ahmad Ud Din, Kamran Ullah, Wei Wang, Guixue Wang
Depression is considered a multifaceted and intricate mental disorder of growing concern due to its significant impact on global health issues. The human gut microbiota, also known as the "second brain," has an important role in the CNS by regulating it through chemical, immunological, hormonal, and neurological processes. Various studies have found a significant bidirectional link between the brain and the gut, emphasizing the onset of depression therapies. The biological and molecular processes underlying depression and microbiota are required, as the bidirectional association may represent a novel study...
2024: Frontiers in Psychiatry
https://read.qxmd.com/read/38393358/-premenstrual-syndrome-and-premenstrual-dysphoric-disorder-overview-on-pathophysiology-diagnostics-and-treatment
#20
REVIEW
Jana Haußmann, M Goeckenjan, R Haußmann, P Wimberger
Premenstrual syndrome and premenstrual dysphoric disorder become episodically manifest during the second half of the female menstrual cycle and are characterized by psychological and physical symptoms causing relevant functional and social impairments. Mood swings, depression and dysphoria are associated depressive symptoms. Therefore, affective disorders should be considered as a differential diagnosis. Of women in reproductive age 3-8% suffer from premenstrual syndrome and 2% of women are affected by premenstrual dysphoric disorder...
February 23, 2024: Der Nervenarzt
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