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uric acid,kidney,renal

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https://www.readbyqxmd.com/read/27924639/similar-developmental-fluctuations-of-hepato-renal-xanthine-oxidoreductase-gene-expression-and-xanthine-oxidase-activity-in-layer-and-broiler-chicken-embryos
#1
D Naseri, K Asasi, I Karimi
1. Xanthine oxidase (XO) has many physiological functions associated with the synthesis of both antioxidant (uric acid: UA) and numerous oxidants (e.g., H2O2), which makes it an important regulator of the cellular redox potential involving organogenesis. The ontogenetic study of hepatic and renal XO makes a better understanding of the putative role of this enzyme in the development of these tissues. 2. Developmental changes of gene expression of xanthine oxidoreductase (XOR), XO activity and UA content of liver and kidney tissues in both broiler and layer chicken embryos were examined during incubation d 14 to 21...
December 7, 2016: British Poultry Science
https://www.readbyqxmd.com/read/27920542/protective-effect-of-tartary-buckwheat-on-renal-function-in-type-2-diabetics-a-randomized-controlled-trial
#2
Ju Qiu, Zaigui Li, Yuchang Qin, Yanfen Yue, Yanping Liu
Tartary buckwheat (TB) has been reported to be associated with a decreased risk of type 2 diabetes mellitus (T2DM), and T2DM has had a major impact on the development of diabetic kidney disease (DKD). Thus, the hypothesis that a daily intake of TB will improve DKD risk factors, including urinary albumin to creatinine ratio (UACR), urea nitrogen (UN), serum creatinine, and uric acid was tested. In a parallel, randomized, open-label controlled trial, 104 T2DM patients were randomly assigned to a diet control group (systematic diet plans and intensive nutritional education) or a TB intervention group (daily replacement of a portion of staple foods with TB foods)...
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/27912887/nephroprotective-effects-of-%C3%AE-bisabolol-against-ischemic-reperfusion-acute-kidney-injury
#3
Tiago Lima Sampaio, Ramon Róseo Paula Pessoa Bezerra de Menezes, Marcus Felipe Bezerra da Costa, Gdayllon Cavalcante Meneses, Mauren Cristina Villalta Arrieta, Adriano José Maia Chaves Filho, Glayciane Bezerra de Morais, Alexandre Braga Libório, Renata Sousa Alves, Janaína Serra Azul Monteiro Evangelista, Alice Maria Costa Martins
BACKGROUND: Ischemia/reperfusion (I/R) in kidney is commonly related to acute kidney injury (AKI), essentially through oxidative stress. (-)-α-Bisabolol is a sesquiterpene isolated from the essential oil of a variety of plants, including chamomile, which has important antioxidant activity. STUDY DESIGN: This study intends to evaluate the nephroprotective activity of (-)-α-bisabolol (Bis) in both in vivo and in vitro models of kidney I/R. METHODS: Male Wistar rats were submitted to right nephrectomy, followed by ischemia by clamping of the renal artery in the left kidney for 60min...
December 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27905009/increased-serum-al-levels-in-hemodialysis-patients-kept-enhanced-during-a-2-year-prospective-study
#4
Maria L Reina de la Torre, Herminia Lopez García de la Serrana, Loreto Martí Del Moral, Magdalena Palomares Bayo, Miguel Navarro-Alarcón
The regulation of mineral homeostasis is altered in hemodialysis patients with renal insufficiency, producing increased risk for secondary diseases like cardiovascular ones. We hypothesized that risen serum aluminum (Al) concentration in hemodialysis patients kept enhanced during a 2-year longitudinal study is associated with enhanced cardiovascular risk and influenced by medical treatments. This study reports the prospective monitoring of serum Al levels in six-monthly samplings over 2 years in 116 hemodialysis patients and a control group of 50 healthy adults...
November 30, 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/27904044/investigation-of-risk-factors-affecting-lactate-levels-in-japanese-patients-treated-with-metformin
#5
Shota Yokoyama, Hideyuki Tsuji, Sachiko Hiraoka, Masayuki Nishihara
Metformin is a biguanaide antidiabetic drug used worldwide, and its effectiveness and benefits have already been established. However, the safety of high doses of metformin in Japanese patients, especially in elderly patients with a decreased renal function, remains unclear. Among the side effects of metformin, lactate acidosis is the most problematic due to a high mortality rate. Therefore, we assessed plasma lactate levels in metformin-treated patients to identify independent risk factors for hyperlactemia...
2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27867961/cardio-renal-protection-with-empagliflozin
#6
Richard J MacIsaac, George Jerums, Elif I Ekinci
Cardiovascular (CV) and kidney disease are common and significant complications in people with type 2 diabetes (T2DM). CV disease is the leading cause of death, morbidly and hospitalisations for people with T2DM. Furthermore, diabetic kidney disease is a major risk factor for CV disease and is the main reason why patients need renal replacement therapy. In this perspective, we highlight the results of the recent landmark EMPA-REG OUTCOME trial which has shown that empagliflozin, a member of the sodium-glucose co-transporter 2 (SGLT-2) inhibitor class of glucose lowering medications, reduces death from CV causes, hospitalisation for heart failure and progression to end stage kidney disease in patients with T2DM and established CV disease...
October 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/27864113/chenopodium-album-linn-leaves-prevent-ethylene-glycol-induced-urolithiasis-in-rats
#7
Indu Sikarwar, Yadu Nandan Dey, Manish M Wanjari, Ajay Sharma, Sudesh N Gaidhani, Ankush D Jadhav
ETHNOPHARMACOLOGICAL RELEVANCE: The leaves of Chenopodium album Linn. are traditionally used for correction of kidney diseases and urinary stones. The present work investigated the effect of methanolic and aqueous extracts of leaves of Chenopodium album on experimentally induced urolithiasis in rats to substantiate its traditional use as antilithiatic agent. MATERIALS AND METHODS: The leaf extract was standardized by HPLC. Urolithiasis was induced in rats by administration 0...
November 15, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27863839/antihyperuricemic-effect-of-liquiritigenin-in-potassium-oxonate-induced-hyperuricemic-rats
#8
Long Hongyan, Wu Suling, Zhu Weina, Zhang Yajie, Ruan Jie
The aim is to investigate the anti-hyperuricemic and renal protective effects of liquiritigenin in potassium oxonate-induced hyperuricemic rats. Hyperuricemia in rats was induced were induced with potassium oxonate (250mg/kg) intragastrically for 7 days, and liquiritigenin (20, 40mg/kg) and allopurinol (5mg/kg) were daily administrated to the rats orally 1h after the potassium oxonate exposure. Liquiritigenin significantly reversed the elevated productions of uric acid in serum and urine and pro-inflammation cytokines in serum and kidney, which shown that liquiritigenin has renal protective effects...
November 15, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27846769/effect-of-cichorium-intybus-l-seed-extract-on-renal-parameters-in-experimentally-induced-early-and-late-diabetes-type-2-in-rats
#9
Yasin Pourfarjam, Lotfollah Rezagholizadeh, Azin Nowrouzi, Alipasha Meysamie, Sarah Ghaseminejad, Nasrin Ziamajidi, Davood Norouzi
Blood and urine biochemistry screening tests are important for initial detection of diabetes, determination of severity of its complications, and monitoring of therapy. We evaluated the effects of aqueous chicory seed extract (CSE), on renal biochemical parameters, histology, and Na+/glucose cotansporters, SGLT1 and SGLT2 expression levels using metformin, and aspirin as controls. Late stage type 2 diabetes (LT2D; FBS, >300 mg/dl) and early stage type 2 diabetes (ET2D; FBS, 140-220 mg/dl) were induced in rats by streptozotocin (STZ group) and a combination of STZ and niacinamide (NIA/STZ group), respectively...
November 16, 2016: Renal Failure
https://www.readbyqxmd.com/read/27843295/effects-of-renal-function-on-pharmacokinetics-and-pharmacodynamics-of-lesinurad-in-adult-volunteers
#10
Michael Gillen, Shakti Valdez, Dongmei Zhou, Bradley Kerr, Caroline A Lee, Zancong Shen
INTRODUCTION: Lesinurad is a selective uric acid reabsorption inhibitor approved for the treatment of gout in combination with a xanthine oxidase inhibitor (XOI) in patients who have not achieved target serum uric acid (sUA) levels with an XOI alone. Most people with gout have chronic kidney disease. The pharmacokinetics, pharmacodynamics, and safety of lesinurad were assessed in subjects with impaired renal function. METHODS: Two Phase I, multicenter, open-label, single-dose studies enrolled subjects with normal renal function (estimated creatinine clearance [eCrCl] >90 mL/min; N=12) or mild (eCrCl 60-89 mL/min; N=8), moderate (eCrCl 30-59 mL/min; N=16), or severe (eCrCl <30 mL/min; N=6) renal impairment...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27829543/paeoniflorin-ameliorates-renal-function-in-cyclophosphamide-induced-mice-via-ampk-suppressed-inflammation-and-apoptosis
#11
Qiang Liu, Xuemei Lin, Hong Li, Jia Yuan, Yuping Peng, Lei Dong, Shejiao Dai
The study is to investigate the effects of paeoniflorin (PA) on renal function in cyclophosphamide-induced mice. Mice were injected with intraperitoneal cyclophosphamide (CYP, 200mg/kg) or saline respectively. Mice were treated with PA (15, 30mg/kg/day) or vehicle for the next 7 days. Then, mice were sacrificed to analyze the biochemical, histological parameters and mechanism research. Our results shown that PA significantly decreased the urine levels of uric acid and creatinine, serum and kidney levels of cytokines such as interleukin-6 (IL-6), interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α), PA also obviously attenuated the histological changes of the kidney tissues caused by CYP...
November 6, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27825577/efficacy-and-safety-of-febuxostat-in-73-gouty-patients-with-stage-4-5-chronic-kidney-disease-a-retrospective-study-of-10-centers
#12
Pierre-Antoine Juge, Marie-Elise Truchetet, Evangeline Pillebout, Sébastien Ottaviani, Cécile Vigneau, Clotilde Loustau, Divi Cornec, Tristan Pascart, Renaud Snanoudj, Florian Bailly, Emilie Cornec-Le Gall, Thierry Schaeverbeke, Alain Saraux, Philippe Dieudé, René-Marc Flipo, Pascal Richette, Frédéric Lioté, Thomas Bardin, Gérard Chalès, Hang-Korng Ea
OBJECTIVES: The allopurinol dose is limited in chronic kidney disease, particularly stage 4/5 chronic kidney disease. Febuxostat has a hepatic metabolism and has been approved without dose adaptation in gouty patients with stage 1-3 chronic kidney disease. We aimed to study the safety and efficacy of febuxostat for stage 4/5 chronic kidney disease. METHODS: In this retrospective study, we included patients with (1) a diagnosis of gout, (2) febuxostat treatment, (3) estimated glomerular filtration rate≤30mL/min/1...
November 4, 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27797893/diet-soda-consumption-and-risk-of-incident-end-stage-renal-disease
#13
Casey M Rebholz, Morgan E Grams, Lyn M Steffen, Deidra C Crews, Cheryl A M Anderson, Lydia A Bazzano, Josef Coresh, Lawrence J Appel
BACKGROUND AND OBJECTIVES: Diet soda consumption is common in the United States and is associated with impaired glucose metabolism, diabetes, and metabolic syndrome. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We prospectively analyzed diet soda consumption, assessed by food frequency questionnaire at baseline (1987-1989) and a follow-up examination (1993-1995), and incident ESRD through December 31, 2012 in the Atherosclerosis Risk in Communities study (n=15,368)...
October 26, 2016: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/27784849/hyperuricemia-as-a-predictive-marker-for-progression-of-nephrosclerosis-clinical-assessment-of-prognostic-factors-in-biopsy-proven-arterial-arteriolar-nephrosclerosis
#14
Kumiko Momoki, Hiroshi Kataoka, Takahito Moriyama, Toshio Mochizuki, Kosaku Nitta
AIM: The influence of serum urate on kidney disease is attracting attention, but the effects of uric acid (UA) on nephrosclerosis have not been elucidated. METHODS: We reviewed data from 45 patients diagnosed with arterial/arteriolar nephrosclerosis. The renal outcomes of the arterial/arteriolar nephrosclerosis patients were assessed by performing logistic and Cox regression analyses. A Kaplan-Meier analysis was used to evaluate the impact of hyperuricemia (HU) on kidney survival...
October 26, 2016: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/27777202/-serum-non-esterified-fatty-acids-to-albumin-ratio-increased-significantly-in-children-with-nephrotic-syndrome
#15
Chun-Li Fan, Jia Wu, Xiao-Min Bu, Shu-Jun Wan, Peng-Tao Guo, Yan-Juan Ma, Jun-Jun Wang
OBJECTIVE: To analyze serum levels of non-esterified fatty acids (NEFA) and albumin (ALB) in children with nephrotic syndrome (NS) and investigate the clinical significance of altered serum NEFA to ALB ratio in children with NS in acute and remission phases. METHODS: Serum levels of NEFA and ALB were measured in 55 NS children in acute phase, in 33 NS children in remission and in 122 healthy control children, and the ratio of NEFA to ALB was calculated. The other lipid/lipoprotein and renal function parameters were also analyzed in these children...
October 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27775590/high-prevalence-of-hyperhomocysteinemia-and-its-association-with-target-organ-damage-in-chinese-patients-with-chronic-kidney-disease
#16
Zengchun Ye, Qunzi Zhang, Yan Li, Cheng Wang, Jun Zhang, Xinxin Ma, Hui Peng, Tanqi Lou
Hyperhomocysteinemia (HHcy) is recognized as a risk factor for cardiovascular disease. However, the prevalence of HHcy and its role in association with target organ damage in patients with chronickidney disease (CKD) are not well understood. This cross-sectional study included 1042 CKD patients who were admitted to our hospital. Patients were divided into two groups: hyperhomocysteinemia and normohomocysteinemia. Multivariable linear regression analyses were used to evaluate the association between plasma homocysteine and renal/cardiovascular parameters...
October 20, 2016: Nutrients
https://www.readbyqxmd.com/read/27774887/lipoprotein-subfractions-uric-acid-and-cardiovascular-risk-in-end-stage-renal-disease-esrd-patients
#17
Anna Gluba-Brzózka, Beata Franczyk, Piotr Bartnicki, Magdalena Rysz-Górzyńska, Jacek Rysz
BACKGROUND: Chronic kidney disease (CKD) poses a worldwide public health problem. CKD is an independent risk factor for cardiovascular disease (CVD). OBJECTIVE: The aim of this study was to assess the cardiovascular risk in ESRD patients and to evaluate the relationship between serum uric acid and lipoprotein subfractions. METHODS: The study group consisted of 66 patients on dialysis and control group of 25 healthy volunteers. Concentration of HDL and LDL subfractions were analysed with Lipoprint™...
October 21, 2016: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27769920/allopurinol-attenuates-rhabdomyolysis-associated-acute-kidney-injury-renal-and-muscular-protection
#18
Pedro H F Gois, Daniele Canale, Rildo A Volpini, Daniela Ferreira, Mariana M Veras, Vinicius Andrade-Oliveira, Niels O S Câmara, Maria H M Shimizu, Antonio C Seguro
BACKGROUND: Acute kidney injury (AKI) is the most severe complication of rhabdomyolysis. Allopurinol (Allo), a xanthine oxidase inhibitor, has been in the spotlight in the last decade due to new therapeutic applications related to its potent antioxidant effect. The aim of this study was to evaluate the efficacy of Allo in the prevention and treatment of rhabdomyolysis-associated AKI. METHODS: Male Wistar rats were divided into five groups: saline control group; prophylactic Allo (300mg/L of drinking water, 7 days); glycerol (50%, 5ml/kg, IM); prophylactic Allo + glycerol; and therapeutic Allo (50mg/Kg, IV, 30min after glycerol injection) + glycerol...
October 18, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27756957/effect-of-hydro-alcoholic-extract-of-vernonia-cinerea-less-against-ethylene-glycol-induced-urolithiasis-in-rats
#19
Ravindra D Hiremath, Sunil S Jalalpure
OBJECTIVE: Aim of this study is to evaluate antiurolithiatic potential of whole plant hydro-alcoholic (30:70) extract of Vernonia cinerea Less. in accordance to its claims made in ancient literature and also being one of the ingredients of cystone, a marketed formulation widely used in the management of urolithiasis. MATERIALS AND METHODS: To induce urolithiasis, 0.75% v/v ethylene glycol was administered orally for 14 days. The curative dose of 400 mg/kg b.w. and preventive doses of 100, 200, and 400 mg/kg b...
July 2016: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/27755482/risk-factors-for-renal-impairment-revealed-after-unilateral-adrenalectomy-in-patients-with-primary-aldosteronism
#20
Do Hee Kim, Hee Jin Kwon, Sang A Ji, Hye Ryoun Jang, Sin-Ho Jung, Jung-Han Kim, Jae Hyeon Kim, Jung Eun Lee, Wooseong Huh, Yoon-Goo Kim, Dae Joong Kim, Ha Young Oh
Primary aldosteronism (PA) may induce significant decline of renal function and structural damage of kidney. However, it is difficult to evaluate accurate renal function in patients with PA, because glomerular hyperfiltration and aldosterone escape can conceal renal impairment. In this retrospective cohort study, we compared changes in renal function after unilateral adrenalectomy between patients with PA and patients with other adrenal diseases. Risk factors associated with postoperative renal impairment in patients with PA were analyzed...
July 2016: Medicine (Baltimore)
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