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https://www.readbyqxmd.com/read/29194632/endothelial-piezo1-channels-as-sensors-of-exercise
#1
David J Beech
Piezo1 channels are newly discovered ion channels which have come to the fore as players in endothelial biology. They have a key role as sensors of shear stress, a frictional force which arises in vascular biology because of blood flow. Endothelial Piezo1 channels are critical in murine embryonic development, just after the heart starts to beat and drive blood into the nascent endothelial network. In contrast they are not critical at the adult stage but they are important for performance in whole body physical activity where they have a vascular bed-specific effect to cause mesenteric resistance artery vasoconstriction, achieved through opposition to the vasodilatory mechanism of endothelium-derived hyperpolarization...
December 1, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29163196/an-inertial-sensor-based-method-for-estimating-the-athlete-s-relative-joint-center-positions-and-center-of-mass-kinematics-in-alpine-ski-racing
#2
Benedikt Fasel, Jörg Spörri, Pascal Schütz, Silvio Lorenzetti, Kamiar Aminian
For the purpose of gaining a deeper understanding of the relationship between external training load and health in competitive alpine skiing, an accurate and precise estimation of the athlete's kinematics is an essential methodological prerequisite. This study proposes an inertial sensor-based method to estimate the athlete's relative joint center positions and center of mass (CoM) kinematics in alpine skiing. Eleven inertial sensors were fixed to the lower and upper limbs, trunk, and head. The relative positions of the ankle, knee, hip, shoulder, elbow, and wrist joint centers, as well as the athlete's CoM kinematics were validated against a marker-based optoelectronic motion capture system during indoor carpet skiing...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29119326/neurodegeneration-and-the-ordered-assembly-of-%C3%AE-synuclein
#3
REVIEW
Maria Grazia Spillantini, Michel Goedert
In 2017, it was 200 years since James Parkinson published 'An Essay on the Shaking Palsy' and 20 years since α-synuclein aggregation came to the fore. In 1998, multiple system atrophy joined Parkinson's disease and dementia with Lewy bodies as the third major synucleinopathy. Here, we describe the work that led to the identification of α-synuclein in Lewy bodies, Lewy neurites and Papp-Lantos bodies. We also review some of the findings reported since 1997.
November 8, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/29049394/electrical-impedance-myography-detects-age-related-muscle-change-in-mice
#4
W David Arnold, Rebecca S Taylor, Jia Li, Janice A Nagy, Benjamin Sanchez, Seward B Rutkove
Loss of muscle mass and strength represents one of the most significant contributors to impaired function in older adults. Convenient and non-invasive biomarkers are needed that can readily identify and track age-related muscle change. Previous data has suggested electrical impedance myography (EIM) has the potential to serve in this capacity. In this study we investigated how changes in EIM compared with other standard measures of muscle structure and function in aged compared with young mice. A total of 19 male mice aged approximately 25 months and 19 male mice aged 3 months underwent surface multifrequency EIM of the right gastrocnemius muscle using standard methods...
2017: PloS One
https://www.readbyqxmd.com/read/29046377/morphospaces-of-functionally-analogous-traits-show-ecological-separation-between-birds-and-pterosaurs
#5
Nicholas R Chan
Birds originated and radiated in the presence of another group of flying vertebrates, the pterosaurs. Opinion is divided as to whether birds competitively displaced pterosaurs from small-body size niches or whether the two groups coexisted with little competition. Previous studies of Mesozoic birds and pterosaurs compared measurements of homologous limb bones to test these hypotheses. However, these characters probably reflect differing ancestries rather than ecologies. Here, competition and ecological separation were tested for using multivariate analyses of functionally equivalent morphological characters...
October 25, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29031999/analysis-of-biases-in-dynamic-margins-of-stability-introduced-by-the-use-of-simplified-center-of-mass-estimates-during-walking-and-turning
#6
Kathryn L Havens, Tatri Mukherjee, James M Finley
The ability to control the body's center of mass (CoM) is critical for preventing falls, which are a major health concern in aging populations. Control of the CoM has been assessed by characterizing dynamic margins of stability (MoS) which capture the dynamic relationship between the CoM and the base of support. Accurate estimation of CoM dynamics is best accomplished using a full-body marker set. However, a number of simplified estimates have been used throughout literature. Here, we determined the biases and sources of bias when computing MoS using four simplified CoM models, and we characterized how these biases varied in straight walking versus turning...
January 2018: Gait & Posture
https://www.readbyqxmd.com/read/28989728/walking-with-wider-steps-changes-foot-placement-control-increases-kinematic-variability-and-does-not-improve-linear-stability
#7
Jennifer A Perry, Manoj Srinivasan
Walking humans respond to pulls or pushes on their upper body by changing where they place their foot on the next step. Usually, they place their foot further along the direction of the upper body perturbation. Here, we examine how this foot placement response is affected by the average step width during walking. We performed experiments with humans walking on a treadmill, both normally and at five different prescribed step widths. We prescribed step widths by requiring subjects to step on lines drawn on the treadmill belt...
September 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28861752/ground-reaction-forces-during-walking-with-different-load-and-slope-combinations-in-rats
#8
N Bravenboer, B T T M van Rens, H W van Essen, J H van Dieën, P Lips
BACKGROUND: Treadmill animal models are commonly used to study effects of exercise on bone. Since mechanical loading induces bone strain, resulting in bone formation, exercise that induces higher strains is likely to cause more bone formation. Our aim was to investigate the effect of slope and additional load on limb bone strain. METHODS: Horizontal and vertical ground reaction forces on left fore-limb (FL) and hind-limb (HL) of twenty 23-week old female Wistar rats (weight 279 ± 26 g) were measured for six combinations of SLOPE (-10°, 0°, +10°) and LOAD (0 to 23% of body mass)...
August 31, 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28840787/altering-plant-defenses-herbivore-associated-molecular-patterns-and-effector-arsenal-of-chewing-herbivores
#9
Saumik Basu, Suresh Varsani, Joe Louis
Chewing herbivores, such as caterpillars and beetles, while feeding on the host plant, cause extensive tissue damage and release a wide array of cues to alter plant defenses. Consequently, the cues can have both beneficial and detrimental impacts on the chewing herbivores. Herbivore-associated molecular patterns (HAMPs) are molecules produced by herbivorous insects that aid them to elicit plant defenses leading to impairment of insect growth, while effectors suppress plant defenses and contribute to increased susceptibility to subsequent feeding by chewing herbivores...
October 12, 2017: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/28780186/dynamic-forces-over-the-interface-between-a-seated-human-body-and-a-rigid-seat-during-vertical-whole-body-vibration
#10
Chi Liu, Yi Qiu, Michael J Griffin
Biodynamic responses of the seated human body are usually measured and modelled assuming a single point of vibration excitation. With vertical vibration excitation, this study investigated how forces are distributed over the body-seat interface. Vertical and fore-and-aft forces were measured beneath the ischial tuberosities, middle thighs, and front thighs of 14 subjects sitting on a rigid flat seat in three postures with different thigh contact while exposed to random vertical vibration at three magnitudes...
July 25, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28762876/constraints-on-stance-phase-force-production-during-overground-walking-in-persons-with-chronic-incomplete-spinal-cord-injury
#11
Denise M Peters, Yann Thibaudier, Joan E Deffeyes, Gila T Baer, Heather B Hayes, Randy D Trumbower
Persons with incomplete spinal cord injury (iSCI) face ongoing struggles with walking, including reduced speed and increased reliance on assistive devices (ADs). The forces underlying body weight support and gait, as measured by ground reaction forces (GRFs), are likely altered after iSCI because of weakness and AD dependence but have not been studied. The purpose of this study was to examine GRF production during overground walking after iSCI, because greater insight into GRF constraints is important for refining therapeutic interventions...
October 27, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28754717/role-of-outstretched-fore-legs-of-flying-beetles-revealed-and-demonstrated-by-remote-leg-stimulation-in-free-flight
#12
Yao Li, Feng Cao, Tat Thang Vo Doan, Hirotaka Sato
In flight, many insects fold their forelegs tightly close to the body, which naturally decreases drag or air resistance. However, flying beetles stretch out their forelegs for some reason. Why do they adopt this posture in flight? Here, we show the role of the stretched forelegs in beetle Mecynorrhina torquata flight. Using leg motion tracking and electromyography in flight, we found that the forelegs were voluntarily swung clockwise in yaw to induce counter-clockwise rotation of the body for turning left, and vice versa...
July 28, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28693568/anorexia-nervosa-and-cancer-a-protocol-for-a-systematic-review-and-meta-analysis-of-observational-studies
#13
Ferrán Catalá-López, Brian Hutton, Jane A Driver, Manuel Ridao, José M Valderas, Ricard Gènova-Maleras, Jaume Forés-Martos, Adolfo Alonso-Arroyo, Diego Macías Saint-Gerons, Eduard Vieta, Alfonso Valencia, Rafael Tabarés-Seisdedos
BACKGROUND: Anorexia nervosa is characterized by a severe restriction of caloric intake, low body weight, fear of gaining weight or of becoming fat, and disturbance of body image. Pathogenesis of the disorder may include genetic predisposition, hormonal changes and a combination of environmental, psychosocial, and cultural factors. Cancer is the second leading cause of death worldwide. At present, no systematic reviews and meta-analyses have evaluated the risk of cancer in people with anorexia nervosa...
July 11, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28693445/older-persons-existential-loneliness-as-interpreted-by-their-significant-others-an-interview-study
#14
Helena Larsson, Margareta Rämgård, Ingrid Bolmsjö
BACKGROUND: In order to better understand people in demanding medical situations, an awareness of existential concerns is important. Studies performed over the last twenty years conclude that when dying and death come closer, as in the case with older people who are stricken by infirmity and diseases, existential concerns will come to the fore. However, studies concerning experiences of existential loneliness (EL) are sparse and, in addition, there is no clear definition of EL. EL is described as a complex phenomenon and referred to as a condition of life, an experience, and a process of inner growth...
July 10, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28655302/a-qualitative-understanding-of-the-effects-of-reusable-sanitary-pads-and-puberty-education-implications-for-future-research-and-practice
#15
Julie Hennegan, Catherine Dolan, Laurel Steinfield, Paul Montgomery
BACKGROUND: The management of menstruation has come to the fore as a barrier to girls' education attainment in low income contexts. Interventions have been proposed and piloted, but the emerging nature of the field means limited evidence is available to understand their pathways of effect. METHODS: This study describes and compares schoolgirls' experiences of menstruation in rural Uganda at the conclusion of a controlled trial of puberty education and sanitary pad provision to elucidate pathways of effect in the interventions...
June 27, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28649932/a-web-of-gaps-a-discussion-of-research-strands-concerning-global-south-families-with-a-disabled-child
#16
Xanthe Hunt, Brian Watermeyer
BACKGROUND: In low- and middle-income countries (LMICs), limited access to a range of supports means that families often carry primary responsibility for the care of a disabled child. The impact of this responsibility is poorly understood. OBJECTIVE: To present a selective review, critique, and comparison of the prominent areas of research aimed at understanding families with disabled children in the Global South. DESIGN: We compare and critically discuss prominent bodies of literature concerning the family-disability-poverty nexus in LMICs...
2017: Global Health Action
https://www.readbyqxmd.com/read/28622929/catarrhine-hallucal-metatarsals-from-the-early-miocene-site-of-songhor-kenya
#17
Biren A Patel, Gabriel S Yapuncich, Cassandra Tran, Isaiah O Nengo
Songhor is an early Miocene fossil locality in Kenya known for its diverse primate assemblage that includes catarrhine species belonging to the genera Kalepithecus, Limnopithecus, Dendropithecus, Rangwapithecus, and Proconsul. Expeditions to Songhor since the 1930s have recovered unassociated catarrhine postcranial remains from both the fore- and hindlimbs, including multiple elements from the feet. In this study, we describe KNM-SO 31233, a complete left hallucal metatarsal (Mt1), along with several other fragmentary Mt1 specimens (KNM-SO 1080, 5129, 5141, 22235)...
July 2017: Journal of Human Evolution
https://www.readbyqxmd.com/read/28610752/age-ascription-as-a-resource-and-a-source-of-resistance-an-interactional-study-of-health-professionals-castings-of-patients-into-the-category-old
#18
Shirley Näslund
This case study aims to give an understanding of what actions health professionals' castings of patients into the category 'old' perform on a medical and social level as well as what actions patients' interactional management of these castings perform. Particularly, this study aims to bring to the fore the negotiability of health professionals' perspectivating age ascriptions. This is done with the conversation analytic method (CA) according to which altercasting is a mutual construction performed turn by turn and shaped by the reactions of the interlocutor who can approve, resist, or modify the identity in question...
April 2017: Journal of Aging Studies
https://www.readbyqxmd.com/read/28610317/a-new-species-of-limnonectes-amphibia-anura-dicroglossidae-from-vietnam
#19
Cuong The Pham, Minh Duc Le, Tao Thien Nguyen, Thomas Ziegler, Zheng Jun Wu, Truong Quang Nguyen
A new species of Limnonectes is described from northeastern Vietnam based on morphological and molecular differences. Morphologically, the new species is distinguishable from its congeners on the basis of a combination of the following diagnostic characters: Large size (SVL 50.1-68.9 in males, 45.5-63.0 mm in females); males with moderately enlarged head (HL/SVL 0.48), head longer than wide; vomerine teeth present; external vocal sacs absent; rostral length short (RL/SVL 0.16 in males, 0.15 in females); tympanum distinct (TD/ED 0...
May 24, 2017: Zootaxa
https://www.readbyqxmd.com/read/28609888/a-new-karst-dwelling-species-of-the-gekko-japonicus-group-squamata-gekkonidae-from-central-laos
#20
Vinh Quang Luu, Truong Quang Nguyen, Minh Duc Le, Michael Bonkowski, Thomas Ziegler
A new species of the Gekko japonicus group is described from Khammouane Province, central Laos, based on morphological characters and molecular data. Morphologically, Gekko nadenensis sp. nov. is differentiated from the remaining congeners by a combination of the following characters: size moderate (SVL 61.0-77.1 mm); nares bordered with rostral; internasals absent; postmentals enlarged; interorbital scales between anterior corners of the eyes 28-30; dorsal tubercles absent; ventral scales between mental and cloacal slit 175-185; midbody scale rows 123-140; ventral scale rows 38-40; subdigital lamellae on first toes 13-15, on fourth toes 14-16; finger and toe webbing present at base; tubercles on dorsal surface of fore and hind limbs absent; precloacal pores six (3+3 or 5+1) in a discontinuous row in males, absent in the female; postcloacal tubercles 1 or 2; tubercles absent on dorsal surface of tail base; subcaudals distinctly enlarged; dorsal surface of body with greyish brown blotches...
May 8, 2017: Zootaxa
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