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Chronic intestinal pseudo-obstruction children

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https://www.readbyqxmd.com/read/27683196/chronic-intestinal-pseudo-obstruction-in-children-and-adults-diagnosis-and-therapeutic-options
#1
G Di Nardo, C Di Lorenzo, A Lauro, V Stanghellini, N Thapar, T B Karunaratne, U Volta, R De Giorgio
BACKGROUND: Chronic intestinal pseudo-obstruction (CIPO) represents the most severe form of gastrointestinal dysmotility with debilitating and potentially lethal consequences. Symptoms can be non-specific, and result in this condition being diagnosed incorrectly or too late with consequences for morbidity and even mortality. PURPOSE: The present article aims to provide pediatric and adult gastroenterologists with an up to date review about clinical features, diagnosis and therapeutic options for CIPO...
September 29, 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27520652/utility-of-octreotide-in-advancing-enteral-feeds-in-children-with-chronic-intestinal-pseudo-obstruction
#2
Lusine Ambartsumyan, Alejandro Flores, Samuel Nurko, Leonel Rodriguez
OBJECTIVES: Chronic intestinal pseudo-obstruction (CIPO) is a challenging disorder with high morbidity and mortality due to limited effective therapies that improve enteral tolerance. We aimed to present our experience using octreotide in children with CIPO and evaluate factors predicting therapy response. METHODS: The study population included total parenteral nutrition (TPN)-dependent children with CIPO receiving octreotide at a tertiary care center. Octreotide response was defined as an enteral feeding increase of ≥10 cc/kg/day...
October 2016: Paediatric Drugs
https://www.readbyqxmd.com/read/27066448/poor-prognostic-factors-in-patients-with-parenteral-nutrition-dependent-pediatric-intestinal-failure
#3
Shin Jie Choi, Kyung Jae Lee, Jong Sub Choi, Hye Ran Yang, Jin Soo Moon, Ju Young Chang, Jae Sung Ko
PURPOSE: Parenteral nutrition (PN) not only provides nutritional support but also plays a crucial role in the treatment of children with intestinal failure. The aim of this study was to evaluate the clinical significance and clinical outcomes of long-term PN. METHODS: Retrospective cohort study was conducted using the medical records of patients treated at Seoul National University Children's Hospital. This study included 19 patients who received PN for over six months...
March 2016: Pediatric Gastroenterology, Hepatology & Nutrition
https://www.readbyqxmd.com/read/27030532/outcome-of-home-parenteral-nutrition-in-251-children-over-a-14-y-period-report-of-a-single-center
#4
Elie Abi Nader, Cécile Lambe, Cécile Talbotec, Bénédicte Pigneur, Florence Lacaille, Hélène Garnier-Lengliné, Laetitia-Marie Petit, Catherine Poisson, Amélia Rocha, Odile Corriol, Yves Aigrain, Christophe Chardot, Frank M Ruemmele, Virginie Colomb-Jung, Olivier Goulet
BACKGROUND: Parenteral nutrition (PN) is the main treatment for intestinal failure. OBJECTIVE: We aimed to review the indications for home parenteral nutrition (HPN) in children and describe the outcome over a 14-y period from a single center. DESIGN: We conducted a retrospective study that included all children who were referred to our institution and discharged while receiving HPN between 1 January 2000 and 31 December 2013. The indications for HPN were divided into primary digestive diseases (PDDs) and primary nondigestive diseases (PNDDs)...
May 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/26875467/-efficacy-of-percutaneous-endoscopic-gastrostomy-in-pediatric-patients
#5
Huiwen Li, Sitang Gong, Min Yang, Peiyu Chen, Zhaohui Xu, Cuiping Liang, Tiefu Fang, Lu Ren, Liying Liu, Jiexia Li, Lanlan Geng
OBJECTIVE: To analyze the efficacy of percutaneous endoscopic gastrostomy (PEG) in pediatric patients. METHOD: From October 2011 to October 2014, children in the gastrointestinal ward of Guangzhou Women and Children's Medical Center received PEG or jejunal tube PEG(JET-PEG). The success rate, operation time were recorded. The changes of their weight, enteral nutrition calories and the incidence of pneumonia before and after the first 6 months of operation were compared...
February 2016: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/26439549/op-8-social-concerns-in-children-being-investigated-for-chronic-intestinal-pseudo-obstruction
#6
Brind J, Bowring E, Larmour K, Cronin H, Barkley L, Rybak A, Saliakellis E, Lindley Kj, Borrelli O, Thapar N
BACKGROUND AND AIMS: Fabricated induced illness (FII) is recognised amongst children presenting with suspected Chronic Intestinal Pseudo-Obstruction (CIPO) (Hyman 2012). We aimed to investigate the presence, nature and potential causes of social concerns in children being referred to our national centre with possible CIPO. METHODS: All patients accepted into the CIPO diagnostic pathway over 3 years (April 2012-April 2015) were reviewed. Acceptance criteria included all of the following (1) referral from a paediatric gastroenterologist or surgeon suspecting a diagnosis of CIPO, (2) mechanical obstruction of the intestine excluded and 3) reliance on specialised enteral or parenteral feeding...
October 2015: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/26361414/pediatric-intestinal-motility-disorders
#7
REVIEW
Stefan Gfroerer, Udo Rolle
Pediatric intestinal motility disorders affect many children and thus not only impose a significant impact on pediatric health care in general but also on the quality of life of the affected patient. Furthermore, some of these conditions might also have implications for adulthood. Pediatric intestinal motility disorders frequently present as chronic constipation in toddler age children. Most of these conditions are functional, meaning that constipation does not have an organic etiology, but in 5% of the cases, an underlying, clearly organic disorder can be identified...
September 7, 2015: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/26033472/belgian-multicenter-experience-with-intestinal-transplantation
#8
Laurens J Ceulemans, Diethard Monbaliu, Arnaud De Roover, Olivier Detry, Roberto I Troisi, Xavier Rogiers, Raymond Reding, Jan P Lerut, Dirk Ysebaert, Thierry Chapelle, Jacques Pirenne
Intestinal transplantation (ITx) has evolved from an experimental procedure toward a clinical reality but remains a challenging procedure. The aim of this survey was to analyze the multicenter Belgian ITx experience. From 1999 to 2014, 24 ITx in 23 patients were performed in Belgium, divided over five centers. Median recipient age was 38 years (8 months-57 years); male/female ratio was 13/10; six were children; and 17 adults. Intestinal failure was related to intestinal ischemia (n = 5), volvulus (n = 5), splanchnic thrombosis (n = 4), Crohn (n = 2), pseudo-obstruction (n = 2), microvillus inclusion (n = 2), Churg-Strauss (n = 1), necrotizing enterocolitis (n = 1), intestinal atresia (n = 1), and chronic rejection (n = 1)...
December 2015: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/25926033/clinical-management-of-post-pyloric-enteral-feeding-in-children
#9
REVIEW
Teresa Capriati, Sabrina Cardile, Fabrizio Chiusolo, Filippo Torroni, Paolo Schingo, Domenica Elia, Antonella Diamanti
Post-pyloric feeding (PF) allows the administration of enteral nutrition beyond the pylorus, either into the duodenum or, ideally, into the jejunum. The main indications of PF are: upper gastrointestinal tract obstructions, pancreatic rest (e.g., acute pancreatitis), gastric dysmotility (e.g., critically ill patients and chronic intestinal pseudo-obstruction) or severe gastroesophageal reflux with risk of aspiration (e.g., neurological disability). Physiological and clinical evidence derives from adults, but can also be pertinent to children...
July 2015: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/25522309/reevaluation-of-acetylcholinesterase-staining-for-the-diagnosis-of-hirschsprung-disease-and-allied-disorders
#10
Iskandar R Budianto, Satoshi Obata, Yoshiaki Kinoshita, Koichiro Yoshimaru, Yusuke Yanagi, Junko Miyata, Kouji Nagata, Satoshi Ieiri, Tomoaki Taguchi
OBJECTIVES: Acetylcholinesterase (AChE) staining has become the gold standard for definitively diagnosing Hirschsprung disease (HD), although some pitfalls have been reported. We reevaluated a large series at our institute in order to validate the accuracy of AChE staining for detecting HD. METHODS: A retrospective study of the rectal mucosal specimens of all of the children with suspected HD during a 13-year period was performed. The specimens were stained according to the modified Karnovsky-Roots method for AChE staining...
May 2015: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/25487487/pediatric-chronic-intestinal-pseudo-obstruction-is-a-rare-serious-and-intractable-disease-a-report-of-a-nationwide-survey-in-japan
#11
Mitsuru Muto, Hiroshi Matsufuji, Takeshi Tomomasa, Atsushi Nakajima, Hisayoshi Kawahara, Shinobu Ida, Kosuke Ushijima, Akio Kubota, Sotaro Mushiake, Tomoaki Taguchi
BACKGROUND/PURPOSE: A nationwide survey was conducted to identify the clinical presentation of pediatric chronic intestinal pseudo-obstruction (CIPO) in Japan. METHODS: Data were collected via a questionnaire, ensuring patient anonymity, from facilities that treat pediatric gastrointestinal diseases in Japan. RESULTS: Ninety-two responses were collected from forty-seven facilities. Sixty-two patients (28 males, 34 females) met formal diagnostic criteria for CIPO...
December 2014: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/25343071/chronic-intestinal-pseudo-obstruction-due-to-lymphocytic-intestinal-leiomyositis-case-report-and-literature-review
#12
Keiichi Uchida, Kohei Otake, Mikihiro Inoue, Yuhki Koike, Kohei Matsushita, Toshimitsu Araki, Yoshiki Okita, Koji Tanaka, Katsunori Uchida, Noriko Yodoya, Shotaro Iwamoto, Katsuhiro Arai, Masato Kusunoki
Lymphocytic intestinal leiomyositis is a rare entity, which causes chronic intestinal pseudo-obstruction (CIPO) in children. We present the first case of a boy who had pure red cell anemia 1 year before onset. Prolonged ileus developed after gastroenteritis and the patient was diagnosed using a biopsy of the intestinal wall. Findings from the present case indicate that there are three important factors for accurate diagnosis: history of enteritis, positive serum smooth muscle antibody, and lymphocyte infiltration with muscle destruction in the muscularis propria in the intestinal wall...
February 2012: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/24847194/functional-aerophagia-in-children-a-frequent-atypical-disorder
#13
Giuliana Morabito, Claudia Romeo, Claudio Romano
Aerophagia is a functional gastrointestinal disorder characterized by repetitive air swallowing, abdominal distension, belching and flatulence. Pathologic aerophagia is a condition caused by the swallowing of excessive volumes of air with associated various gastrointestinal symptoms, such as burping, abdominal cramps, flatulence and a reduced appetite. It is a clinical entity that can simulate pediatric gastrointestinal motility disorders, such as gastroparesis, megacolon and intestinal pseudo-obstruction, and presents more frequently in children with mental retardation...
January 2014: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/24799835/gastrointestinal-motility-disorders-in-children
#14
Lusine Ambartsumyan, Leonel Rodriguez
The most common and challenging gastrointestinal motility disorders in children include gastroesophageal reflux disease (GERD), esophageal achalasia, gastroparesis, chronic intestinal pseudo-obstruction, and constipation. GERD is the most common gastrointestinal motility disorder affecting children and is diagnosed clinically and treated primarily with acid secretion blockade. Esophageal achalasia, a less common disorder in the pediatric patient population, is characterized by dysphagia and treated with pneumatic balloon dilation and/or esophagomyotomy...
January 2014: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/23641741/state-s-pull-through-for-total-colonic-aganglionosis-and-gi-dismotility
#15
Ahmad Khaleghnejad Tabari, Hamid Foroutan, Abbas Banani, Leily Mohajerzadeh, Mohsen Ruozrokh, Alireza Mirshemirani
BACKGROUND: Total colonic aganglionosis (TCA) is present in 4% - 5% of the patients with Hirschsprung's disease and has a high surgical mortality rate between 13% - 23%. Diagnosis and treatment of TCA is still a major challenge for pediatric surgeons. Many techniques with several advantages and disadvantages were established for its treatment. We have performed State's pull-through as total colectomy and ileo-proctostomy with long posterior rectal myotomy in TCA and severe dysmotility disorders...
May 2013: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/23414861/surgical-treatment-and-outcomes-of-severe-pediatric-intestinal-motility-disorders-requiring-parenteral-nutrition
#16
Mikko P Pakarinen, Annika Kurvinen, Antti I Koivusalo, Tarja Ruuska, Heikki Mäkisalo, Hannu Jalanko, Risto J Rintala
AIM: The aim of this study was to characterize outcomes of children with severe intestinal motility disorders (IMD) requiring parenteral nutrition (PN). METHODS: Twenty consecutive children with primary IMD requiring long-term PN between 1984 and 2010 were included. Median (interquartile range) follow-up was 13.1 (5.2-20.1) years. Treatment, PN dependence, growth, nutritional status, liver function, and survival were assessed. RESULTS: Underlying etiology included chronic intestinal pseudo obstruction (CIPO; n=8) and Hirschsprung disease with extensive aganglionosis (n=12)...
February 2013: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/22946581/an-unusual-case-of-ogilvie-syndrome-in-a-pediatric-oncology-patient-receiving-palliative-care-after-failed-treatment-with-neostigmine
#17
Liza-Marie Johnson, Holly L Spraker, Jamie L Coleman, Justin N Baker
BACKGROUND: We present a case of severe refractory constipation in an adolescent oncology patient with widely metastatic clear cell osteosarcoma who was ultimately found to have Ogilvie syndrome, also known as acute colonic pseudo-obstruction (ACPO). Ogilvie syndrome is characterized by dilatation of the large intestine in the absence of mechanical obstruction, usually occurring in adult patients with serious underlying medical conditions and rarely seen in children. It is likely that chronic narcotic use, abdominal metastasis, and a paraneoplastic process contributed to development of ACPO in this patient...
September 2012: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/22827765/an-adult-case-of-midgut-volvulus-in-familial-visceral-myopathy
#18
Takahiko Nakajima, Nobuyuki Matsuhashi, Satoshi Nara, Atsushi Nakajima, Johji Imura, Atsushi Kihara, Kenichiro Murata, Junichi Fukushima, Hajime Horiuchi
We report an adult case of midgut volvulus in familial visceral myopathy (FVM) that had affected family members over three generations. The patient was a Japanese woman in her fifties, who had chronic intestinal pseudo-obstruction (CIPO) since the age of about 40 years and had been treated chronically with conservative therapies. Her abdominal symptoms suddenly worsened and surgery became necessary. Surgery revealed a midgut volvulus secondary to intestinal malrotation and the twisted intestine was resected...
August 2012: Pathology International
https://www.readbyqxmd.com/read/22820123/intestinal-failure-in-children-the-european-view
#19
REVIEW
Lorenzo D'Antiga, Olivier Goulet
Intestinal failure (IF) is a condition in which severe intestinal malabsorption mandates artificial nutrition through a parenteral route. Causes of severe protracted IF include short bowel syndrome, congenital diseases of enterocyte development, and severe motility disorders (total or subtotal aganglionosis or chronic intestinal pseudo-obstruction syndrome). IF can result in nutritional failure, defined as the long-term failure to nourish a child by natural or artificial means. Today, IF-associated liver disease is the most common cause of parenteral nutrition (PN) failure, but catheter-related sepsis and extensive vascular thrombosis may also jeopardize the health of those receiving PN...
February 2013: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/22688601/use-of-buprenorphine-in-children-with-chronic-pseudoobstruction-syndrome-case-series-and-review-of-literature
#20
REVIEW
Sunisa Prapaitrakool, Markus W Hollmann, Hans Christian Wartenberg, Benedikt Preckel, Stefan Brugger
OBJECTIVES: Abdominal pain is the most challenging symptom in chronic intestinal pseudoobstruction (CIPO) syndrome, because of its severity and the limited availability of suitable opioid formulations, especially in pediatric patients with digestive problems. Most of the children with CIPO cannot tolerate oral formulations. CASE REPORTS: We present 4 cases of children with CIPO and severe intractable abdominal pain, and report on the use of a recently available form of opioid, transdermal buprenorphine in a dosage of 5 mcg/h...
October 2012: Clinical Journal of Pain
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