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Melissa Desmedt, Sonja Vertriest, Johan Hellings, Jochen Bergs, Ezra Dessers, Patrik Vankrunkelsven, Hubertus Vrijhoef, Lieven Annemans, Nick Verhaeghe, Mirko Petrovic, Dominique Vandijck
OBJECTIVES: To assess the costs and potential financial benefits of integrated care models for patients with chronic diseases, that is, type 2 diabetes mellitus, schizophrenia, and multiple sclerosis, respectively. METHODS: A systematic search of the literature was performed using EMBASE, MEDLINE, and Web of Science. Studies that conducted a cost analysis, considered at least two components of the chronic care model, and compared integrated care with standard care were included...
September 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Hyuna Park, Min-Jae Kim, Junga Lee, Ji Hee Min, Ji Young Kim, Ji Yong Byeon, Mi Seong Yu, Jae Woo Park, Minkyu Jung, Joong Bae Ahn, Justin Y Jeon
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
Ioana Todor, Adina Popa, Maria Neag, Dana Muntean, Corina Bocsan, Anca Buzoianu, Laurian Vlase, Ana-Maria Gheldiu, Corina Briciu
PURPOSE: To evaluate the impact of bupropion on the pharmacokinetic profile of atomoxetine and its main active metabolite (glucuronidated form), 4-hydroxyatomoxetine-O-glucuronide, in healthy volunteers. METHODS: An open-label, non-randomized, two-period, sequential clinical trial was conducted as follows: during Period I (Reference), each volunteer received a single oral dose of 25 mg atomoxetine, whilst during Period II (Test), a combination of 25 mg atomoxetine and 300 mg bupropion was administered to all volunteers, after a pretreatment regimen with bupropion for 7 days...
April 2016: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
Wolfgang Hüttel, Loubna Youssar, Björn A Grüning, Stefan Günther, Katharina G Hugentobler
BACKGROUND: Echinocandins are nonribosomal lipopeptides produced by ascommycete fungi. Due to their strong inhibitory effect on fungal cell wall biosynthesis and lack of human toxicity, they have been developed to an important class of antifungal drugs. Since 2012, the biosynthetic gene clusters of most of the main echinocandin variants have been characterized. Especially the comparison of the clusters allows a deeper insight for the biosynthesis of these complex structures. RESULTS: In the genome of the echinocandin B producer Aspergillus nidulans NRRL 8112 we have identified a gene cluster (Ani) that encodes echinocandin biosynthesis...
2016: BMC Genomics
Gerrit Angst, Stephan John, Carsten W Mueller, Ingrid Kögel-Knabner, Janet Rethemeyer
Soil organic carbon (SOC) from aboveground and belowground sources has rarely been differentiated although it may drive SOC turnover and stabilization due to a presumed differing source dependent degradability. It is thus crucial to better identify the location of SOC from different sources for the parameterization of SOC models, especially in the less investigated subsoils. The aim of this study was to spatially assess contributions of organic carbon from aboveground and belowground parts of beech trees to subsoil organic carbon in a Dystric Cambisol...
2016: Scientific Reports
J Ren, B Z He, T S Zhang, S P Lu, T Yan
The aim of this meta-analysis was to assess the association between a polymorphism (-3860 G > A) in the cytochrome P450 1A2 (CYP1A2) gene and lung cancer susceptibility. Relevant studies were retrieved from the PubMed and EMBase databases, and additionally evaluated for conformance with the inclusion criteria. The odds ratios (ORs) and their 95% confidence intervals (95%CIs) in all selected studies were used to assess the relationship between the CYP1A2 -3860 G > A polymorphism and lung cancer risk. The data was pooled using Stata v...
2016: Genetics and Molecular Research: GMR
Hiroki Watanabe, Nobuyuki Horita, Yuji Shibata, Shintaro Minegishi, Erika Ota, Takeshi Kaneko
Diagnostic test accuracy of D-dimer for acute aortic dissection (AAD) has not been evaluated by meta-analysis with the bivariate model methodology. Four databases were electrically searched. We included both case-control and cohort studies that could provide sufficient data concerning both sensitivity and specificity of D-dimer for AAD. Non-English language articles and conference abstract were allowed. Intramural hematoma and penetrating aortic ulcer were regarded as AAD. Based on 22 eligible articles consisting of 1140 AAD subjects and 3860 non-AAD subjects, the diagnostic odds ratio was 28...
2016: Scientific Reports
Jennie Lin, Yu Hu, Sara Nunez, Andrea S Foulkes, Benjamin Cieply, Chenyi Xue, Mark Gerelus, Wenjun Li, Hanrui Zhang, Daniel J Rader, Kiran Musunuru, Mingyao Li, Muredach P Reilly
OBJECTIVE: Human macrophages can shift phenotype across the inflammatory M1 and reparative M2 spectrum in response to environmental challenges, but the mechanisms promoting inflammatory and cardiometabolic disease-associated M1 phenotypes remain incompletely understood. Alternative splicing (AS) is emerging as an important regulator of cellular function, yet its role in macrophage activation is largely unknown. We investigated the extent to which AS occurs in M1 activation within the cardiometabolic disease context and validated a functional genomic cell model for studying human macrophage-related AS events...
July 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
Jonathan A Harounian, Eric Schaefer, Jane Schubart, Michele M Carr
OBJECTIVE: To examine variations in management of pediatric posttonsillectomy hemorrhage and associated costs from a national third-party payer perspective. STUDY DESIGN: The MarketScan database was analyzed for claims made for 30 days following tonsillectomy/adenotonsillectomy between 2008 and 2012 for privately insured children aged 1 to 17 years. Costs for management of postoperative hemorrhage by age, sex, and region were calculated in addition to total costs incurred for 30 days postoperatively...
August 2016: Otolaryngology—Head and Neck Surgery
Ting-Ting Song, Yan-Hua Bi, Yu-Qi Gao, Rui Huang, Ke Hao, Gang Xu, Jia-Wei Tang, Zhi-Qiang Ma, Fan-Ping Kong, John H Coote, Xue-Qun Chen, Ji-Zeng Du
BACKGROUND: High-altitude cerebral edema (HACE) is the severe type of acute mountain sickness (AMS) and life threatening. A subclinical inflammation has been speculated, but the exact mechanisms underlying the HACE are not fully understood. METHODS: Human volunteers ascended to high altitude (3860 m, 2 days), and rats were exposed to hypoxia in a hypobaric chamber (5000 m, 2 days). Human acute mountain sickness was evaluated by the Lake Louise Score (LLS), and plasma corticotrophin-releasing hormone (CRH) and cytokines TNF-α, IL-1β, and IL-6 were measured in rats and humans...
2016: Journal of Neuroinflammation
Giovanni Filardo, Briget da Graca, Danielle M Sass, Benjamin D Pollock, Emma B Smith, Melissa Ashley-Marie Martinez
OBJECTIVE: To examine changes in representation of women among first authors of original research published in high impact general medical journals from 1994 to 2014 and investigate differences between journals. DESIGN: Observational study. STUDY SAMPLE: All original research articles published in Annals of Internal Medicine, Archives of Internal Medicine, The BMJ, JAMA, The Lancet, and the New England Journal of Medicine (NEJM) for one issue every alternate month from February 1994 to June 2014...
2016: BMJ: British Medical Journal
Lakshmi Mudambi, Andrew Spiegelman, Duncan Geron, Max Hirshkowitz, Babak Mokhlesi, Yasser Shaib, Suryakanta Velamuri, Charlie O Lan, Amir Sharafkhaneh
RATIONALE: The use of sedation allows medical procedures to be performed outside the operating room while ensuring patient comfort and a controlled environment to increase the yield of the procedure. There is concern about a higher risk of adverse events with use of sedation in patients with obstructive sleep apnea. OBJECTIVES: We aimed to determine if the presence of obstructive sleep apnea increased the risk of hospitalization and/or health care use after patients received moderate conscious sedation for an elective, ambulatory colonoscopy...
March 2016: Annals of the American Thoracic Society
Charles Osalumese Imarengiaye, Theodore Ojeide Isesele
INTRODUCTION: The burden of hypertensive diseases on the health care is enormous given to the high population in Sub-Saharan Africa and related disproportionate representation in global maternal mortality. MATERIALS AND METHODS: All women with hypertensive diseases of pregnancy who got admitted into the general ICU of the University of Benin Teaching Hospital between January 2006 and December 2010 were studied. Only the records of women who completed 28 weeks of gestation and were admitted during labour and delivery or puerperium to the ICU were examined...
September 2015: Nigerian Medical Journal: Journal of the Nigeria Medical Association
Gregory B Maletis, Jason Chen, Maria C S Inacio, Tadashi T Funahashi
BACKGROUND: It is not clear whether risk factors for revision anterior cruciate ligament reconstruction (ACLR) are the same throughout patients' lives. PURPOSE: To assess (1) the risk of revision ACLR by age and (2) age-specific risk factors for revision ACLR. STUDY DESIGN: Cohort study; Level of evidence, 2. METHODS: A cohort study using patients having undergone primary ACLR who were registered in the Kaiser Permanente ACLR Registry (February 2005 to June 2013) was conducted...
February 2016: American Journal of Sports Medicine
Xiang Huang, Huajie Yang, Harry H X Wang, Yongjun Qiu, Xiujuan Lai, Zhiheng Zhou, Fangjian Li, Liwei Zhang, Jiaji Wang, Jimin Lei
BACKGROUND: Non-communicable chronic diseases (NCDs) have become the top threat in China. This study aimed to estimate the prevalence of major NCDs among the elderly population in rural areas in southern China and explore its associated social determinants. METHODS: A multistage cluster random sampling methodology was adopted to select a total of 9245 rural elderly people from 3860 rural households in Guangdong Province. Interviews and physical examinations were performed to collect patient information...
October 2015: International Journal of Environmental Research and Public Health
Atsuhiko Murata, Toshihiko Mayumi, Kohji Okamoto, Makoto Ohtani, Shinya Matsuda
OBJECTIVES: This study aimed to investigate the recent time trend of outcomes for severe acute pancreatitis after publication of Japanese guidelines based on a national administrative database. METHODS: A total of 10,400 patients with severe acute pancreatitis were referred to 1021 hospitals between 2010 and 2012 in Japan. We collected patients' data from the administrative database to compare in-hospital mortality (within 28 days and overall), length of stay (LOS), and medical costs during hospitalization...
April 2016: Pancreas
Krithi K Karanth
Wildlife reserves are becoming increasingly isolated from the surrounding human-dominated landscapes particularly in Asia. It is imperative to understand how species are distributed spatially and temporally in and outside reserves, and what factors influence their occurrence. This study surveyed 7500 km(2) landscape surrounding five reserves in the Western Ghats to examine patterns of occurrence of five herbivores: elephant, gaur, sambar, chital, and pig. Species distributions are modeled spatio-temporally using an occupancy approach...
January 2016: Environmental Management
Susannah K Wallace, Dorothy K Waller, Barbara C Tilley, Linda B Piller, Kristen J Price, Nisha Rathi, Sajid Haque, Joseph L Nates
BACKGROUND: The majority of hospital deaths in the United States occur after ICU admission. The characteristics associated with the place of death within the hospital are not known for patients with cancer. OBJECTIVE: The study objective was to identify patient characteristics associated with place of death among hospitalized patients with cancer who were at the end of life. METHODS: A retrospective cohort study design was implemented. Subjects were consecutive patients hospitalized between 2003 and 2007 at a large comprehensive cancer center in the United States...
August 2015: Journal of Palliative Medicine
Ayari Imene, Arnaud J Maurice, Mani Arij, Pavanello Sofia, Saguem Saad
The aim of the present study was to evaluate the relative contribution of CYP1A2 isoforms (-3860 G/A, -2467T/delT and -163C/A) in control subjects and breast cancer patients to the metabolism of caffeine in human liver. Restriction fragment length polymorphism analysis of PCR-amplified Fragments (PCR-RFLP) was used for the genotyping of CYP1A2 SNPs and HPLC allowed the phenotyping through the measurement of CYP1A2 activity using the 17X + 13X + 37X/137X urinary metabolite ratio (CMR) and plasma caffeine half life (T1/2)...
2015: Asian Pacific Journal of Cancer Prevention: APJCP
Jean-Michel Costes, Sylvia Kairouz, Vincent Eroukmanoff, Eva Monson
In 2010 France enacted a law to regulate supply and consumption of online gambling. Its primary aim was to protect citizens from gambling-related harm. This study aims to assess differences in gambling patterns and related harm between online gamblers who use licensed versus unlicensed sites. Participants (N = 3860) completed a self-administered online survey on gambling practices. Pairwise logistic regressions examined the association between the legal statuses of gambling sites people patronized and demographic variables and gambling types...
March 2016: Journal of Gambling Studies
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