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Chiu-Wen Su, Amy Ming-Fang Yen, Hongmin Lai, Yungling Lee, Hsiu-Hsi Chen, Sam Li-Sheng Chen
OBJECTIVES: We evaluated whether and how the effects of risk factors on periodontal disease (PD) were modified by measurement errors using community periodontal index (CPI) and loss attachment (LA) in the community{\hyphen}based survey. METHODS: A pilot validation study was performed to estimate the rates of false negative and false positive for both CPI and LA in 31 subjects from different regions using measurements from 12 well{\hyphen}trained dentists and a senior periodontist as a gold standard...
April 17, 2017: Oral Diseases
Zachary A Ichter, Lindsay Voeller, Homero Rivas, Habib Khoury, Dan Azagury, John M Morton
BACKGROUND: Bariatric surgery is a well-tolerated and effective treatment for severe obesity. Newer surgical techniques and equipment have improved safety standards surrounding bariatric surgery. In particular, buttressing of the staple line in sleeve gastrectomy has decreased rates of clinically significant postoperative bleeding. The present study investigates the effectiveness of buttressing the circular stapled anastomosis during laparoscopic Roux-en-Y gastric bypass (LRYGB). SETTING: Academic, accredited hospital...
January 11, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
Anuj Garg, Kripal Bhalala, Devendra Singh Tomar, Wahajuddin
The present investigation aims to develop lumefantrine loaded binary solid lipid nanoparticles (LF-SLNs) to improve its poor and variable oral bioavailability. The oral bioavailability of LF is poor and variable due to its limited aqueous solubility and P-gp mediated efflux occurring in small intestine. LF-SLNs were prepared using binary lipid mixture of stearic acid and caprylic acid stabilized with TPGS (D-alpha tocopheryl polyethylene glycol 1000 succinate) and Poloxamer 188. Developed LF-SLNs were characterized for particle size distribution, zeta potential, entrapment efficiency, solid state properties and biopharmaceutical properties including in situ intestinal permeability and oral bioavailability...
January 10, 2017: International Journal of Pharmaceutics
Juan Carlos García-Ramos, Anllely Grizett Gutiérrez, Adriana Vázquez-Aguirre, Yanis Toledano-Magaña, Ana Luisa Alonso-Sáenz, Virginia Gómez-Vidales, Marcos Flores-Alamo, Carmen Mejía, Lena Ruiz-Azuara
The family of Copper(II) coordination compounds Casiopeínas(®) (Cas) has shown antiproliferative activity in several tumour lines by oxidative cellular damage and mitochondrial dysfunction that lead to cell death through apoptotic pathways. The goal of this work is looking for the functional mechanism of CasIIgly, CasIIIia and CasIIIEa in neuroblastoma metastatic cell line SK-N-SH, a paediatric extra-cranial tumour which is refractory to several anti-carcinogenic agents. All Cas have shown higher antiproliferative activity than cisplatin (IC50 = 123 μM) with IC50 values of 18, 22 and 63 µM for CasIIgly, CasIIIEa and CasIIIia, respectively...
February 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
Wen-Yen Chiou, Chien-An Chen, Moon-Sing Lee, Hon-Yi Lin, Chung-Yi Li, Yu-Chieh Su, Shiang-Jiun Tsai, Shih-Kai Hung
As the number of long-term cervical cancer survivors continues to increase because of improvements in treatment, concerns about second primary malignancy have grown. The high-risk area of second primary cancers in cervical cancer survivors is the pelvis. Pelvic inflammatory disease (PID) could be a useful marker for gynecological cancers. Thus, we designed a large-scale, nationwide, controlled cohort study to investigate whether PID or other risk factors increased the risk of second primary cancers in patients with cervical cancer treated by surgery alone...
November 2016: Medicine (Baltimore)
Melissa Desmedt, Sonja Vertriest, Johan Hellings, Jochen Bergs, Ezra Dessers, Patrik Vankrunkelsven, Hubertus Vrijhoef, Lieven Annemans, Nick Verhaeghe, Mirko Petrovic, Dominique Vandijck
OBJECTIVES: To assess the costs and potential financial benefits of integrated care models for patients with chronic diseases, that is, type 2 diabetes mellitus, schizophrenia, and multiple sclerosis, respectively. METHODS: A systematic search of the literature was performed using EMBASE, MEDLINE, and Web of Science. Studies that conducted a cost analysis, considered at least two components of the chronic care model, and compared integrated care with standard care were included...
September 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Hyuna Park, Min-Jae Kim, Junga Lee, Ji Hee Min, Ji Young Kim, Ji Yong Byeon, Mi Seong Yu, Jae Woo Park, Minkyu Jung, Joong Bae Ahn, Justin Y Jeon
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
Ioana Todor, Adina Popa, Maria Neag, Dana Muntean, Corina Bocsan, Anca Buzoianu, Laurian Vlase, Ana-Maria Gheldiu, Corina Briciu
PURPOSE: To evaluate the impact of bupropion on the pharmacokinetic profile of atomoxetine and its main active metabolite (glucuronidated form), 4-hydroxyatomoxetine-O-glucuronide, in healthy volunteers. METHODS: An open-label, non-randomized, two-period, sequential clinical trial was conducted as follows: during Period I (Reference), each volunteer received a single oral dose of 25 mg atomoxetine, whilst during Period II (Test), a combination of 25 mg atomoxetine and 300 mg bupropion was administered to all volunteers, after a pretreatment regimen with bupropion for 7 days...
April 2016: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
Wolfgang Hüttel, Loubna Youssar, Björn A Grüning, Stefan Günther, Katharina G Hugentobler
BACKGROUND: Echinocandins are nonribosomal lipopeptides produced by ascommycete fungi. Due to their strong inhibitory effect on fungal cell wall biosynthesis and lack of human toxicity, they have been developed to an important class of antifungal drugs. Since 2012, the biosynthetic gene clusters of most of the main echinocandin variants have been characterized. Especially the comparison of the clusters allows a deeper insight for the biosynthesis of these complex structures. RESULTS: In the genome of the echinocandin B producer Aspergillus nidulans NRRL 8112 we have identified a gene cluster (Ani) that encodes echinocandin biosynthesis...
2016: BMC Genomics
Gerrit Angst, Stephan John, Carsten W Mueller, Ingrid Kögel-Knabner, Janet Rethemeyer
Soil organic carbon (SOC) from aboveground and belowground sources has rarely been differentiated although it may drive SOC turnover and stabilization due to a presumed differing source dependent degradability. It is thus crucial to better identify the location of SOC from different sources for the parameterization of SOC models, especially in the less investigated subsoils. The aim of this study was to spatially assess contributions of organic carbon from aboveground and belowground parts of beech trees to subsoil organic carbon in a Dystric Cambisol...
2016: Scientific Reports
J Ren, B Z He, T S Zhang, S P Lu, T Yan
The aim of this meta-analysis was to assess the association between a polymorphism (-3860 G > A) in the cytochrome P450 1A2 (CYP1A2) gene and lung cancer susceptibility. Relevant studies were retrieved from the PubMed and EMBase databases, and additionally evaluated for conformance with the inclusion criteria. The odds ratios (ORs) and their 95% confidence intervals (95%CIs) in all selected studies were used to assess the relationship between the CYP1A2 -3860 G > A polymorphism and lung cancer risk. The data was pooled using Stata v...
June 17, 2016: Genetics and Molecular Research: GMR
Hiroki Watanabe, Nobuyuki Horita, Yuji Shibata, Shintaro Minegishi, Erika Ota, Takeshi Kaneko
Diagnostic test accuracy of D-dimer for acute aortic dissection (AAD) has not been evaluated by meta-analysis with the bivariate model methodology. Four databases were electrically searched. We included both case-control and cohort studies that could provide sufficient data concerning both sensitivity and specificity of D-dimer for AAD. Non-English language articles and conference abstract were allowed. Intramural hematoma and penetrating aortic ulcer were regarded as AAD. Based on 22 eligible articles consisting of 1140 AAD subjects and 3860 non-AAD subjects, the diagnostic odds ratio was 28...
May 27, 2016: Scientific Reports
Jennie Lin, Yu Hu, Sara Nunez, Andrea S Foulkes, Benjamin Cieply, Chenyi Xue, Mark Gerelus, Wenjun Li, Hanrui Zhang, Daniel J Rader, Kiran Musunuru, Mingyao Li, Muredach P Reilly
OBJECTIVE: Human macrophages can shift phenotype across the inflammatory M1 and reparative M2 spectrum in response to environmental challenges, but the mechanisms promoting inflammatory and cardiometabolic disease-associated M1 phenotypes remain incompletely understood. Alternative splicing (AS) is emerging as an important regulator of cellular function, yet its role in macrophage activation is largely unknown. We investigated the extent to which AS occurs in M1 activation within the cardiometabolic disease context and validated a functional genomic cell model for studying human macrophage-related AS events...
July 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
Jonathan A Harounian, Eric Schaefer, Jane Schubart, Michele M Carr
OBJECTIVE: To examine variations in management of pediatric posttonsillectomy hemorrhage and associated costs from a national third-party payer perspective. STUDY DESIGN: The MarketScan database was analyzed for claims made for 30 days following tonsillectomy/adenotonsillectomy between 2008 and 2012 for privately insured children aged 1 to 17 years. Costs for management of postoperative hemorrhage by age, sex, and region were calculated in addition to total costs incurred for 30 days postoperatively...
August 2016: Otolaryngology—Head and Neck Surgery
Ting-Ting Song, Yan-Hua Bi, Yu-Qi Gao, Rui Huang, Ke Hao, Gang Xu, Jia-Wei Tang, Zhi-Qiang Ma, Fan-Ping Kong, John H Coote, Xue-Qun Chen, Ji-Zeng Du
BACKGROUND: High-altitude cerebral edema (HACE) is the severe type of acute mountain sickness (AMS) and life threatening. A subclinical inflammation has been speculated, but the exact mechanisms underlying the HACE are not fully understood. METHODS: Human volunteers ascended to high altitude (3860 m, 2 days), and rats were exposed to hypoxia in a hypobaric chamber (5000 m, 2 days). Human acute mountain sickness was evaluated by the Lake Louise Score (LLS), and plasma corticotrophin-releasing hormone (CRH) and cytokines TNF-α, IL-1β, and IL-6 were measured in rats and humans...
March 11, 2016: Journal of Neuroinflammation
Giovanni Filardo, Briget da Graca, Danielle M Sass, Benjamin D Pollock, Emma B Smith, Melissa Ashley-Marie Martinez
OBJECTIVE: To examine changes in representation of women among first authors of original research published in high impact general medical journals from 1994 to 2014 and investigate differences between journals. DESIGN: Observational study. STUDY SAMPLE: All original research articles published in Annals of Internal Medicine, Archives of Internal Medicine, The BMJ, JAMA, The Lancet, and the New England Journal of Medicine (NEJM) for one issue every alternate month from February 1994 to June 2014...
March 2, 2016: BMJ: British Medical Journal
Lakshmi Mudambi, Andrew Spiegelman, Duncan Geron, Max Hirshkowitz, Babak Mokhlesi, Yasser Shaib, Suryakanta Velamuri, Charlie O Lan, Amir Sharafkhaneh
RATIONALE: The use of sedation allows medical procedures to be performed outside the operating room while ensuring patient comfort and a controlled environment to increase the yield of the procedure. There is concern about a higher risk of adverse events with use of sedation in patients with obstructive sleep apnea. OBJECTIVES: We aimed to determine if the presence of obstructive sleep apnea increased the risk of hospitalization and/or health care use after patients received moderate conscious sedation for an elective, ambulatory colonoscopy...
March 2016: Annals of the American Thoracic Society
Charles Osalumese Imarengiaye, Theodore Ojeide Isesele
INTRODUCTION: The burden of hypertensive diseases on the health care is enormous given to the high population in Sub-Saharan Africa and related disproportionate representation in global maternal mortality. MATERIALS AND METHODS: All women with hypertensive diseases of pregnancy who got admitted into the general ICU of the University of Benin Teaching Hospital between January 2006 and December 2010 were studied. Only the records of women who completed 28 weeks of gestation and were admitted during labour and delivery or puerperium to the ICU were examined...
September 2015: Nigerian Medical Journal: Journal of the Nigeria Medical Association
Gregory B Maletis, Jason Chen, Maria C S Inacio, Tadashi T Funahashi
BACKGROUND: It is not clear whether risk factors for revision anterior cruciate ligament reconstruction (ACLR) are the same throughout patients' lives. PURPOSE: To assess (1) the risk of revision ACLR by age and (2) age-specific risk factors for revision ACLR. STUDY DESIGN: Cohort study; Level of evidence, 2. METHODS: A cohort study using patients having undergone primary ACLR who were registered in the Kaiser Permanente ACLR Registry (February 2005 to June 2013) was conducted...
February 2016: American Journal of Sports Medicine
Xiang Huang, Huajie Yang, Harry H X Wang, Yongjun Qiu, Xiujuan Lai, Zhiheng Zhou, Fangjian Li, Liwei Zhang, Jiaji Wang, Jimin Lei
BACKGROUND: Non-communicable chronic diseases (NCDs) have become the top threat in China. This study aimed to estimate the prevalence of major NCDs among the elderly population in rural areas in southern China and explore its associated social determinants. METHODS: A multistage cluster random sampling methodology was adopted to select a total of 9245 rural elderly people from 3860 rural households in Guangdong Province. Interviews and physical examinations were performed to collect patient information...
October 2015: International Journal of Environmental Research and Public Health
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