Casey Hensley, Sandro Roier, Peng Zhou, Sofia Schnur, Charlotte Nyblade, Viviana Parreno, Annie Frazier, Maggie Frazier, Kelsey Kiley, Samantha O'Brien, Yu Liang, Bryan T Mayer, Ruizhe Wu, Celia Mahoney, Monica M McNeal, Benjamin Petsch, Susanne Rauch, Lijuan Yuan
Human rotavirus (HRV) is still a leading cause of severe dehydrating gastroenteritis globally, particularly in infants and children. Previously, we demonstrated the immunogenicity of mRNA-based HRV vaccine candidates expressing the viral spike protein VP8* in rodent models. In the present study, we assessed the immunogenicity and protective efficacy of two mRNA-based HRV trivalent vaccine candidates, encoding VP8* of the genotypes P[8], P[6], or P[4], in the gnotobiotic (Gn) pig model of Wa (G1P[8]) HRV infection and diarrhea...
March 1, 2024: Vaccines