keyword
MENU ▼
Read by QxMD icon Read
search

Rotavirus

keyword
https://www.readbyqxmd.com/read/29684739/evaluating-meteorological-data-from-weather-stations-and-from-satellites-and-global-models-for-a-multi-site-epidemiological-study
#1
Josh M Colston, Tahmeed Ahmed, Cloupas Mahopo, Gagandeep Kang, Margaret Kosek, Francisco de Sousa Junior, Prakash Sunder Shrestha, Erling Svensen, Ali Turab, Benjamin Zaitchik
BACKGROUND: Longitudinal and time series analyses are needed to characterize the associations between hydrometeorological parameters and health outcomes. Earth Observation (EO) climate data products derived from satellites and global model-based reanalysis have the potential to be used as surrogates in situations and locations where weather-station based observations are inadequate or incomplete. However, these products often lack direct evaluation at specific sites of epidemiological interest...
April 20, 2018: Environmental Research
https://www.readbyqxmd.com/read/29682555/preparation-and-evaluation-of-combined-detection-of-norovirus-gi-and-gii-an-innovative-fluorescent-particles-test-strip
#2
Lifang Zhang, Yanxia Peng, Na Jiang, Lei Shi, Jieping Lin, Ping Wu, Qingjun Pan
This study was designed to prepare and evaluate the sensitivity and specificity of a Norovirus GI and GII fluorescent particles combined detection test strip method. Using selected chromatographic materials and antibodies specific to Norovirus GI and GII, the Norovirus GI and GII fluorescent particles combined detection test strip (tested method) was prepared as a conventional double antibody sandwich. The samples assayed included cultured rotavirus and 465 specimens from patients with symptoms of gastrointestinal infection...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29681427/incidence-and-characteristics-of-norovirus-associated-benign-convulsions-with-mild-gastroenteritis-in-comparison-with-rotavirus-ones
#3
Bo Ram Kim, Ga Eun Choi, Young Ok Kim, Min Ji Kim, Eun Song Song, Young Jong Woo
BACKGROUND AND PURPOSE: Rotavirus was detected in 40-50% of patients with benign convulsions with mild gastroenteritis (CwG) before the rotavirus vaccine was introduced in late 2000. However, the rate of rotavirus positivity has decreased since 2010 while the prevalence of norovirus has gradually increased. We investigated the incidence of norovirus-associated CwG during a recent 3-year period and additionally compared the characteristics of norovirus-associated CwG with those of rotavirus-associated CwG...
April 19, 2018: Brain & Development
https://www.readbyqxmd.com/read/29679373/cytokine-producing-b-cells-promote-immune-mediated-bile-duct-injury-in-murine-biliary-atresia
#4
Joseph Bednarek, Brianna Traxinger, Dania Brigham, Jonathan Roach, David Orlicky, Dong Wang, Roberta Pelanda, Cara L Mack
Biliary atresia (BA) is a neonatal T cell-mediated inflammatory, sclerosing cholangiopathy. In the Rhesus rotavirus (RRV)-induced neonatal mouse model of BA (murine BA), mice lacking B cells do not develop BA, and the lack of B cells is associated with loss of T cell and macrophage activation. The aim of this study was to determine the mechanism of B cell-mediated immune activation (antigen presentation versus cytokine production) in murine BA. RESULTS: Normal neonatal B cells in the liver are predominantly at pro-B and pre-B cellular development...
April 20, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29677111/genome-characterization-of-a-pathogenic-porcine-rotavirus-b-strain-identified-in-buryat-republic-russia-in-2015
#5
Konstantin P Alekseev, Aleksey A Penin, Alexey N Mukhin, Kizkhalum M Khametova, Tatyana V Grebennikova, Anton G Yuzhakov, Anna S Moskvina, Maria I Musienko, Sergey A Raev, Alexandr M Mishin, Alexandr P Kotelnikov, Oleg A Verkhovsky, Taras I Aliper, Eugeny A Nepoklonov, Diana M Herrera-Ibata, Frances K Shepherd, Douglas G Marthaler
An outbreak of enteric disease of unknown etiology with 60% morbidity and 8% mortality in weaning piglets occurred in November 2015 on a farm in Buryat Republic, Russia. Metagenomic sequencing revealed the presence of rotavirus B in feces from diseased piglets while no other pathogens were identified. Clinical disease was reproduced in experimentally infected piglets, yielding the 11 RVB gene segments for strain Buryat15, with an RVB genotype constellation of G12-P[4]-I13-R4-C4-M4-A8-N10-T4-E4-H7. This genotype constellation has also been identified in the United States...
April 20, 2018: Pathogens
https://www.readbyqxmd.com/read/29671592/inactivation-mechanisms-of-human-and-animal-rotaviruses-by-solar-uva-and-visible-light
#6
Elbashir Araud, Joanna L Shisler, Thanh H Nguyen
Two rotavirus (RV) strains (sialidase-resistant Wa and sialidase-sensitive OSU) were irradiated with simulated solar UVA and visible light in sensitizer-free phosphate buffered solution (lacking exogenous reactive oxygen species (ROS)) or secondary effluent wastewater (producing ROS). Although light attenuated for up to 15% through the secondary effluent wastewater (SEW), the inactivation efficacies increased by 0.7 log10 for Wa and 2 log10 for OSU compared to those in sensitizer-free phosphate buffered solution (PBS) after 4 hrs of irradiation...
April 19, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29670610/neonatal-immunization-rationale-current-state-and-future-prospects
#7
REVIEW
Elizabeth Whittaker, David Goldblatt, Peter McIntyre, Ofer Levy
Infections take their greatest toll in early life necessitating robust approaches to protect the very young. Here, we review the rationale, current state, and future research directions for one such approach: neonatal immunization. Challenges to neonatal immunization include natural concern about safety as well as a distinct neonatal immune system that is generally polarized against Th1 responses to many stimuli such that some vaccines that are effective in adults are not in newborns. Nevertheless, neonatal immunization could result in high-population penetration as birth is a reliable point of healthcare contact, and offers an opportunity for early protection of the young, including preterm newborns who are deficient in maternal antibodies...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29670022/whole-genome-classification-and-phylogenetic-analyses-of-rotavirus-b-strains-from-the-united-states
#8
Frances K Shepherd, Diana Maria Herrera-Ibata, Elizabeth Porter, Nitipong Homwong, Richard Hesse, Jianfa Bai, Douglas G Marthaler
Rotaviruses (RVs) are a major etiological agent of acute viral gastroenteritis in humans and young animals, with rotavirus B (RVB) often detected in suckling and weaned pigs. Group A rotavirus classification is currently based on the two outer capsid proteins, VP7 and VP4, and the middle layer protein, VP6. Using RVB strains generated in this study and reference sequences from GenBank, pairwise identity frequency graphs and phylogenetic trees were constructed for the eleven gene segments of RVB to estimate the nucleotide identity cutoff values for different genotypes and determine the genotype diversity per gene segment...
April 18, 2018: Pathogens
https://www.readbyqxmd.com/read/29669834/generation-of-recombinant-rotaviruses-expressing-fluorescent-proteins-using-an-optimized-reverse-genetics-system
#9
Satoshi Komoto, Saori Fukuda, Tomihiko Ide, Naoto Ito, Makoto Sugiyama, Tetsushi Yoshikawa, Takayuki Murata, Koki Taniguchi
An entirely plasmid-based reverse genetics system for rotaviruses was established very recently. We improved the reverse genetics system to generate recombinant rotavirus by transfecting only 11 cDNA plasmids for its 11 gene segments under the condition of increasing the ratio of the cDNA plasmids for NSP2 and NSP5 genes. Utilizing this highly efficient system, we then engineered infectious recombinant rotaviruses expressing bioluminescent (NanoLuc luciferase) and fluorescent (EGFP and mCherry) reporters. These recombinant rotaviruses expressing reporters remained genetically stable during serial passages...
April 18, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29669224/evaluation-of-intussusception-after-monovalent-rotavirus-vaccination-in-africa
#10
Jacqueline E Tate, Jason M Mwenda, George Armah, Bhavin Jani, Richard Omore, Ayesheshem Ademe, Hilda Mujuru, Evans Mpabalwani, Bagrey Ngwira, Margaret M Cortese, Richard Mihigo, Hope Glover-Addy, Mwajabu Mbaga, Francis Osawa, Amezene Tadesse, Bothwell Mbuwayesango, Julia Simwaka, Nigel Cunliffe, Benjamin A Lopman, Goitom Weldegebriel, Daniel Ansong, David Msuya, Billy Ogwel, Thomas Karengera, Portia Manangazira, Bruce Bvulani, Catherine Yen, Felicitas R Zawaira, Clement T Narh, Lazaro Mboma, Peter Saula, Fasil Teshager, Halle Getachew, Rebecca M Moeti, Christabel Eweronu-Laryea, Umesh D Parashar
BACKGROUND: Postlicensure evaluations have identified an association between rotavirus vaccination and intussusception in several high- and middle-income countries. We assessed the association between monovalent human rotavirus vaccine and intussusception in lower-income sub-Saharan African countries. METHODS: Using active surveillance, we enrolled patients from seven countries (Ethiopia, Ghana, Kenya, Malawi, Tanzania, Zambia, and Zimbabwe) who had intussusception that met international (Brighton Collaboration level 1) criteria...
April 19, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29667207/whole-genomic-analysis-of-human-g8p-14-group-a-rotavirus-detected-from-community-gastroenteritis-outbreak
#11
Mori Kohji, Nakazawa Haruyuki, Hase Shinichi, Nagano Miyuki, Kimoto Kana, Oda Mayuko, Somura Yoshiko, Akiba Tetsuya, Hayashi Yukinao, Shinkai Takayuki, Sadamasu Kenji
Several suspected cases of zoonotic transmission of group A rotavirus (RVA)-related gastroenteritis were reported previously. In August 2012, G8P[14] RVA was detected in fecal specimens from a community gastroenteritis outbreak occurring during a school trip. In this study, additional analyses were performed and it was found that this strain had the G8-P[14]-I2-R2-C2-M2-A3-N2-T6-E2-H3 sequence, similar to bovine-like RVA strains. Some contamination by emesis and diarrheic feces was observed near a rest room in the lodging area...
April 17, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29662691/poverty-reduction-and-equity-benefits-of-introducing-or-scaling-up-measles-rotavirus-and-pneumococcal-vaccines-in-low-income-and-middle-income-countries-a-modelling-study
#12
Carlos Riumallo-Herl, Angela Y Chang, Samantha Clark, Dagna Constenla, Andrew Clark, Logan Brenzel, Stéphane Verguet
Introduction: Beyond their impact on health, vaccines can lead to large economic benefits. While most economic evaluations of vaccines have focused on the health impact of vaccines at a national scale, it is critical to understand how their impact is distributed along population subgroups. Methods: We build a financial risk protection model to evaluate the impact of immunisation against measles, severe pneumococcal disease and severe rotavirus for birth cohorts vaccinated over 2016-2030 for three scenarios in 41 Gavi-eligible countries: no immunisation, current immunisation coverage forecasts and the current immunisation coverage enhanced with funding support...
2018: BMJ Global Health
https://www.readbyqxmd.com/read/29662148/emergence-of-human-g2p-4-rotaviruses-in-the-post-vaccination-era-in-south-korea-footprints-of-multiple-interspecies-re-assortment-events
#13
Hien Dang Thanh, Van Trung Tran, Inseok Lim, Wonyong Kim
After the introduction of two global rotavirus vaccines, RotaTeq in 2007 and Rotarix in 2008 in South Korea, G1[P8] rotavirus was the major rotavirus genotype in the country until 2012. However, in this study, an emergence of G2P[4] as the dominant genotype during the 2013 to 2015 season has been reported. Genetic analysis revealed that these viruses had typical DS-1-like genotype constellation and showed evidence of re-assortment in one or more genome segments, including the incorporation of NSP4 genes from strains B-47/2008 from a cow and R4/Haryana/2007 from a buffalo in India, and the VP1 and VP3 genes from strain GO34/1999 from a goat in Bangladesh...
April 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29662124/stag2-deficiency-induces-interferon-responses-via-cgas-sting-pathway-and-restricts-virus-infection
#14
Siyuan Ding, Jonathan Diep, Ningguo Feng, Lili Ren, Bin Li, Yaw Shin Ooi, Xin Wang, Kevin F Brulois, Linda L Yasukawa, Xingnan Li, Calvin J Kuo, David A Solomon, Jan E Carette, Harry B Greenberg
Cohesin is a multi-subunit nuclear protein complex that coordinates sister chromatid separation during cell division. Highly frequent somatic mutations in genes encoding core cohesin subunits have been reported in multiple cancer types. Here, using a genome-wide CRISPR-Cas9 screening approach to identify host dependency factors and novel innate immune regulators of rotavirus (RV) infection, we demonstrate that the loss of STAG2, an important component of the cohesin complex, confers resistance to RV replication in cell culture and human intestinal enteroids...
April 16, 2018: Nature Communications
https://www.readbyqxmd.com/read/29659924/evaluation-of-a-booster-dose-of-pentavalent-rotavirus-vaccine-co-administered-with-measles-yellow-fever-and-meningitis-a-vaccines-in-9-month-old-malian-infants
#15
Fadima C Haidara, Milagritos D Tapia, Samba O Sow, Moussa Doumbia, Flanon Coulibaly, Fatoumata Diallo, Awa Traoré, Mamoudou Kodio, Corey L Kelly, Meagan Fitzpatrick, Karen Kotloff, John C Victor, Kathleen Neuzil
Background: Rotavirus vaccines given to infants are safe and efficacious. A booster dose of rotavirus vaccine could extend protection into the second year of life in low resource countries. Methods: We conducted an open-label, individual-randomized trial in Bamako, Mali. We assigned 600 9- to 11-month old infants to measles (MV), yellow fever (YFV), and meningococcal A conjugate vaccines with or without pentavalent rotavirus vaccine (PRV). We assessed non-inferiority of seroconversion and seroresponse rates (<10% difference) to MV, YFV and MenAV...
April 12, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29656244/human-organoid-cultures-transformative-new-tools-for-human-virus-studies
#16
REVIEW
Sasirekha Ramani, Sue E Crawford, Sarah E Blutt, Mary K Estes
Studies of human infectious diseases have been limited by the paucity of functional models that mimic normal human physiology and pathophysiology. Recent advances in the development of multicellular, physiologically active organotypic cultures produced from embryonic and pluripotent stem cells, as well as from stem cells isolated from biopsies and surgical specimens are allowing unprecedented new studies and discoveries about host-microbe interactions. Here, we summarize recent developments in the use of organoids for studying human viral pathogens, including intestinal infections with human rotavirus, norovirus, enteroviruses and adenoviruses (intestinal organoids and enteroids), neuronal infections with Zika virus (cerebral organoids) and respiratory infections with respiratory syncytial virus in (lung bud organoids)...
April 12, 2018: Current Opinion in Virology
https://www.readbyqxmd.com/read/29656042/detection-and-molecular-characterization-of-two-rare-g8p-14-and-g3p-3-rotavirus-strains-collected-from-children-with-acute-gastroenteritis-in-japan
#17
Shoko Okitsu, Toshiyuki Hikita, Aksara Thongprachum, Pattara Khamrin, Sayaka Takanashi, Satoshi Hayakawa, Niwat Maneekarn, Hiroshi Ushijima
This study describes the detection and molecular characterization of two rare G8P[14] and G3P[3] rotavirus strains, which were collected from children with acute gastroenteritis in 2014 in Japan. Among 247 rotaviruses, one G8P[14] (strain 12,597) and one G3P[3] (strain 12,638) rotaviruses were detected. The genotypes of 11 gene segments of these two rotavirus strains (RVA/Human-wt/JPN/12597/2014/G8P[14] and RVA/Human-wt/JPN/12638/2014/G3P[3]) were characterized. The genotype constellation of strain 12,597 was assigned to G8-P[14]-I2-R2-C2-M2-A3-N2-T9-E2-H3, and this strain possessed a rare T9 genotype of NSP3 gene which has never been reported previously in combination with G8 genotype of VP7 gene...
April 12, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29655631/detection-of-rotavirus-before-and-after-monovalent-rotavirus-vaccine-introduction-and-vaccine-effectiveness-among-children-in-mainland-tanzania
#18
Bhavin Jani, Adolfine Hokororo, Jackson Mchomvu, Margaret M Cortese, Christopher Kamugisha, Delphinius Mujuni, Dotto Kallovya, Umesh D Parashar, Jason M Mwenda, DaFrossa Lyimo, Antonia Materu, Kakuri Frank Omari, Mark Waziri, Theresia Laswai, Hamisi Juma, Josephine Mlay, Juliana Dogani, Eugenia Stephen, Mwanisha Seugendo, Uyanjo Nkumbi, Anna Lyakurwa, Anivera Matojo, Elice Bendera, Jonathan Senyota, Veronica Msingwa, Yohana Fungo, Fausta Michael, Amina Mpamba, Alfred Chambo, Happy Cholobi, Faraja Lyamuya, Inviollatha Chami, Esther Mchome, Amina Mohamed Mshana, Edward Mushi, Uforo Mariki, Ronica Chard, Deborah Tuju, Nuswe Ambokile, Fatuma Lukwale, Furaha Kyessi, Asha Khamis, Innocent Michael, Doreen Macha, Angelina Saguti
BACKGROUND: Monovalent rotavirus vaccine (RV1) was introduced in Tanzania in January 2013 under the Reach Every Child initiative, to be given at ages 6 and 10 weeks. We used the sentinel hospital rotavirus surveillance system to examine the rotavirus detection rate before and after vaccine introduction and estimate vaccine effectiveness. METHODS: Before vaccine introduction, rotavirus surveillance was established at two mainland hospitals; children admitted for acute diarrhea were eligible for enrollment and stools were tested for rotavirus antigen...
April 11, 2018: Vaccine
https://www.readbyqxmd.com/read/29655628/trends-in-diarrhea-hospitalizations-among-infants-at-three-hospitals-in-tanzania-before-and-after-rotavirus-vaccine-introduction
#19
Faraja Lyamuya, Fausta Michael, Bhavin Jani, Yohana Fungo, Alfred Chambo, Inviolatha Chami, Regina Bulali, Amina Mpamba, Happy Cholobi, Dotto Kallovya, Christopher Kamugisha, Jason M Mwenda, Margaret M Cortese
BACKGROUND: The Tanzania Ministry of Health introduced monovalent human rotavirus vaccine in January 2013, to be administered at ages 6 and 10 weeks. Data suggest there was high vaccine uptake. We used hospital ward registers from 3 hospitals to examine trends in diarrhea hospitalizations among infants before and after vaccine introduction. METHODS: Ward registers from Dodoma Regional Referral Hospital (Central Tanzania), and two hospitals in Mbeya (Southwest area), Mbeya Zonal Referral Hospital and Mbalizi Hospital, were used to tally admissions for diarrhea among children by age group, month and year...
April 11, 2018: Vaccine
https://www.readbyqxmd.com/read/29652903/a-new-method-for-detecting-signal-regions-in-ordered-sequences-of-real-numbers-and-application-to-viral-genomic-data
#20
Julia R Gog, Andrew M L Lever, Jordan P Skittrall
We present a fast, robust and parsimonious approach to detecting signals in an ordered sequence of numbers. Our motivation is in seeking a suitable method to take a sequence of scores corresponding to properties of positions in virus genomes, and find outlying regions of low scores. Suitable statistical methods without using complex models or making many assumptions are surprisingly lacking. We resolve this by developing a method that detects regions of low score within sequences of real numbers. The method makes no assumptions a priori about the length of such a region; it gives the explicit location of the region and scores it statistically...
2018: PloS One
keyword
keyword
3188
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"