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https://www.readbyqxmd.com/read/29456114/detection-and-genetic-characterization-of-mamastrovirus-5-from-brazilian-dogs
#1
Christian D B T Alves, Renata F Budaszewski, Marcela Torikachvili, André F Streck, Matheus N Weber, Samuel P Cibulski, Ana P Ravazzolo, Vagner R Lunge, Cláudio W Canal
Mamastrovirus 5 (MAstV5), belonging to the Astroviridae (AstV) family, previously known as canine astrovirus or astrovirus-like particles, has been reported in several countries to be associated with viral enteric disease in dogs since the 1980s. Astroviruses have been detected in fecal samples from a wide variety of mammals and birds that are associated with gastroenteritis and extra enteric manifestations. In the present study, RT-PCR was used to investigate the presence of MAstV5 in 269 dog fecal samples...
February 2, 2018: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/29455625/diarrhea-caused-by-rotavirus-a-b-and-c-in-suckling-piglets-from-southern-brazil-molecular-detection-and-histologic-and-immunohistochemical-characterization
#2
Paula R Almeida, Elis Lorenzetti, Raquel S Cruz, Tatiane T Watanabe, Priscila Zlotowski, Amauri A Alfieri, David Driemeier
Rotavirus (RV) is an important viral pathogen causing diarrhea in piglets and other mammals worldwide. We describe 34 cases from 4 diarrheal outbreaks caused by RV in unvaccinated farrowing units in southern Brazil from 2011 to 2013. We performed autopsy, histologic examinations, bacterial culture, RV immunohistochemistry (IHC), and enteric virus detection through molecular assays for rotavirus A, B, and C, transmissible gastroenteritis virus, porcine epidemic diarrhea virus, sapovirus, norovirus, and kobuvirus...
February 1, 2018: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/29455326/new-tetrameric-forms-of-the-rotavirus-nsp4-with-antiparallel-helices
#3
Sushant Kumar, Raghavendra Ramappa, Kiranmayee Pamidimukkala, C D Rao, K Suguna
Rotavirus nonstructural protein 4, the first viral enterotoxin to be identified, is a multidomain, multifunctional glycoprotein. Earlier, we reported a Ca2+ -bound coiled-coil tetrameric structure of the diarrhea-inducing region of NSP4 from the rotavirus strains SA11 and I321 and a Ca2+ -free pentameric structure from the rotavirus strain ST3, all with a parallel arrangement of α-helices. pH was found to determine the oligomeric state: a basic pH favoured a tetramer, whereas an acidic pH favoured a pentamer...
February 17, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29454018/co-circulation-of-classic-and-novel-astrovirus-strains-in-patients-with-acute-gastroenteritis-in-germany
#4
Sonja Jacobsen, Marina Höhne, Andreas Mas Marques, Klara Beslmüller, C-Thomas Bock, Sandra Niendorf
OBJECTIVES: In order to analyze the molecular epidemiology of human astroviruses (HAstV) in Germany, a retrospective long term study was performed to characterize circulating human astrovirus in patients with acute gastroenteritis in Germany. METHODS: A total of 2877 stool samples, collected between January 2010 and December 2015 from sporadic cases and outbreaks of acute gastroenteritis were retrospectively analyzed for astrovirus. A two step PCR algorithm was developed and used to identify and characterize human astrovirus infections...
February 14, 2018: Journal of Infection
https://www.readbyqxmd.com/read/29449099/cost-of-goods-sold-and-total-cost-of-delivery-for-oral-and-parenteral-vaccine-packaging-formats
#5
Jeff Sedita, Stefanie Perrella, Matt Morio, Michael Berbari, Jui-Shan Hsu, Eugene Saxon, Courtney Jarrahian, Annie Rein-Weston, Darin Zehrung
Despite limitations of glass packaging for vaccines, the industry has been slow to implement alternative formats. Polymer containers may address many of these limitations, such as breakage and delamination. However, the ability of polymer containers to achieve cost of goods sold (COGS) and total cost of delivery (TCOD) competitive with that of glass containers is unclear, especially for cost-sensitive low- and lower-middle-income countries. COGS and TCOD models for oral and parenteral vaccine packaging formats were developed based on information from subject matter experts, published literature, and Kenya's comprehensive multiyear plan for immunization...
February 12, 2018: Vaccine
https://www.readbyqxmd.com/read/29446580/is-there-any-difference-between-the-symptomatology-and-clinical-findings-of-viral-agents-causing-dehydration
#6
Suat Biçer, Defne Çöl, Öznur Küçük, Gülay Ç Erdağ, Tuba Giray, Meltem Uğraş, Ayça Vitrinel, Çiğdem Kaspar
BACKGROUND: Acute gastroenteritis is responsible for dehydration in many children. The viruses like rotavirus, norovirus, and adenovirus are considered the main causative agents of gastroenteritis. The goal of this study is the evaluation of the symptoms, clinical findings and hospitalization requirements in pediatric patients with dehydration secondary to viral gastroenteritis. METHODS: The distribution of age, symptoms, clinical and laboratory findings and hospitalization requirements of 156 viral acute gastroenteritis patients with moderate dehydration were evaluated retrospectively...
April 2018: Minerva Pediatrica
https://www.readbyqxmd.com/read/29446040/significance-of-continuous-rotavirus-and-norovirus-surveillance-in-indonesia
#7
REVIEW
Mohamad Saifudin Hakim, Hera Nirwati, Abu Tholib Aman, Yati Soenarto, Qiuwei Pan
BACKGROUND: Diarrhea significantly contributes to the global burden of diseases, particularly in developing countries. Rotavirus and norovirus are the most dominant viral agents responsible for diarrheal disease globally. The aim of this review was to conduct a comprehensive assessment of rotavirus and norovirus study in Indonesia. DATA SOURCES: Articles about rotavirus and norovirus surveillance in Indonesia were collected from databases, including PubMed and Google Scholar...
February 14, 2018: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/29444369/rotaviral-non-structural-protein-4-triggers-dynamin-related-protein-1-dependent-mitochondrial-fragmentation-during-infection
#8
Arpita Mukherjee, Upayan Patra, Rahul Bhowmick, Mamta Chawla-Sarkar
Dynamic equilibrium between mitochondrial fission and mitochondrial fusion serves as an important quality control system within cells ensuring cellular vitality and homeostasis. Viruses often target mitochondrial dynamics as a part of their obligatory cellular reprogramming. The present study was undertaken to assess the status and regulation of mitochondrial dynamics during rotavirus (RV) infection. Distinct fragmentation of mitochondrial syncytia was observed during late hours of RV (SA11, Wa, A5-13) infection...
February 14, 2018: Cellular Microbiology
https://www.readbyqxmd.com/read/29444167/rotavirus-vaccine-coverage-and-factors-associated-with-uptake-using-linked-data-ontario-canada
#9
Sarah E Wilson, Hannah Chung, Kevin L Schwartz, Astrid Guttmann, Shelley L Deeks, Jeffrey C Kwong, Natasha S Crowcroft, Laura Wing, Karen Tu
BACKGROUND: In August 2011, Ontario, Canada introduced a rotavirus immunization program using Rotarix™ vaccine. No assessments of rotavirus vaccine coverage have been previously conducted in Ontario. METHODS: We assessed vaccine coverage (series initiation and completion) and factors associated with uptake using the Electronic Medical Record Administrative data Linked Database (EMRALD), a collection of family physician electronic medical records (EMR) linked to health administrative data...
2018: PloS One
https://www.readbyqxmd.com/read/29444124/annual-changes-in-rotavirus-hospitalization-rates-before-and-after-rotavirus-vaccine-implementation-in-the-united-states
#10
Minesh P Shah, Rebecca M Dahl, Umesh D Parashar, Benjamin A Lopman
BACKGROUND: Hospitalizations for rotavirus and acute gastroenteritis (AGE) have declined in the US with rotavirus vaccination, though biennial peaks in incidence in children aged less than 5 years occur. This pattern may be explained by lower rotavirus vaccination coverage in US children (59% to 73% from 2010-2015), resulting in accumulation of susceptible children over two successive birth cohorts. METHODS: Retrospective cohort analysis of claims data of commercially insured US children aged <5 years...
2018: PloS One
https://www.readbyqxmd.com/read/29439867/safety-and-tolerability-of-a-liquid-bovine-rotavirus-pentavalent-vaccine-lbrv-pv-in-adults
#11
K Anil, Sajjad Desai, Chetanraj Bhamare, Abhijeet Dharmadhikari, R L Madhusudhan, Jaya Patel, Prasad S Kulkarni
BACKGROUND: Rotavirus Gastroenteritis (RVGE) is an important global public health problem. Recently a Lyophilized Pentavalent Human Bovine Reassortant Rotavirus vaccine (BRV-PV, Rotasiil) was licensed in India. A Liquid formulation of the same vaccine (LBRV-PV) was tested in a Phase I clinical trial. METHODS: Total 20 healthy adults were given a single oral dose of LBRV-PV and were followed for one month for safety outcomes: immediate reactions, solicited reactions, unsolicited adverse events and serious adverse events...
February 10, 2018: Vaccine
https://www.readbyqxmd.com/read/29439864/incidence-and-epidemiology-of-intussusception-among-children-under-2%C3%A2-years-of-age-in-chenzhou-and-kaifeng-china-2009-2013
#12
Na Liu, Catherine Yen, Tao Huang, Pengwei Cui, Jacqueline E Tate, Baoming Jiang, Umesh D Parashar, Zhao-Jun Duan
INTRODUCTION: In China, rotavirus is the leading cause of diarrhea hospitalizations among children aged <5 years. A locally manufactured rotavirus vaccine is available for private market use, but little is known about its coverage. Given the impending availability of newer rotavirus vaccines, we evaluated intussusception rates among children aged <2 years to better understand intussusception epidemiology for future vaccine safety monitoring. METHODS: We conducted a retrospective review at 4 hospitals in Chenzhou City of Hunan Province and Kaifeng City of Henan Province...
February 10, 2018: Vaccine
https://www.readbyqxmd.com/read/29438743/detection-and-molecular-characterization-of-enteric-viruses-in-children-with-acute-gastroenteritis-in-northern-italy
#13
Valeria Biscaro, Giorgio Piccinelli, Franco Gargiulo, Giovanni Ianiro, Arnaldo Caruso, Francesca Caccuri, Maria Antonia De Francesco
Enteric viral infections are a major concern for public health, and viral acute gastroenteritis is the principal cause of pediatric morbidity and mortality worldwide, mostly in developing countries. The purpose of this study was to determine the prevalence of different enteric viruses detected in a pediatric population with acute gastroenteritis symptoms, and to characterize the strains detected. Stools were collected from children, aged from 2 months to 15 years old, admitted to one of the main hospitals of Northern Italy, between November 2015 and October 2016...
February 10, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29436336/indirect-rotavirus-vaccine-effectiveness-for-the-prevention-of-rotavirus-hospitalization-a-systematic-review-and-meta-analysis
#14
Katherine L Rosettie, Theo Vos, Ali H Mokdad, Abraham D Flaxman, Ibrahim Khalil, Chris Troeger, Marcia R Weaver
Two rotavirus vaccines, RotaTeq and Rotarix, are licensed for global use; however, the protection they confer to unvaccinated individuals through indirect effects remains unknown. We systematically reviewed the literature and quantified indirect rotavirus vaccine effectiveness (VE) for preventing rotavirus hospitalization in children aged less than 5 years. From 148 identified abstracts, 14 studies met our eligibility criteria. In our main analysis using a random-effects model, indirect rotavirus VE was 48% (95% confidence interval [CI]: 39-55%)...
February 12, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29433482/cholesterol-of-lipid-rafts-is-a-key-determinant-for-entry-and-post-entry-control-of-porcine-rotavirus-infection
#15
Xiujing Dou, Yang Li, Junlan Han, Dante S Zarlenga, Weijuan Zhu, Xiaofeng Ren, Na Dong, Xunliang Li, Guangxing Li
BACKGROUND: Lipid rafts are major structural components in plasma membranes that play critical roles in many biological processes including virus infection. However, few reports have described the relationship between lipid rafts and porcine rotavirus (PRV) infection. In this study, we investigated whether or not the locally high concentrations (3-5 fold) of cholesterol present in lipid rafts are required for PRV infection, and further examined which stages of the infection process are most affected...
February 12, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29433417/clinical-findings-and-neurologic-outcome-in-neonatal-encephalopathy-with-white-matter-injury-accompanied-by-rotavirus
#16
Jae Kyun Ku, Young Jin Heo, Keun Soo Lee, Bo Lyun Lee
Our objective was to elucidate the clinical characteristics and neurodevelopmental outcomes in neonatal encephalopathy with characteristic white matter injury as compared with other injury patterns on magnetic resonance diffusion-weighted imaging. We conducted a retrospective study comparing clinical and laboratory findings, and neurologic outcomes between 17 newborns with diffuse lesions in the periventricular white matter and white matter tract (group I) and 22 newborns with other patterns (group II). Stool samples indicated that 16 neonates (94...
March 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29433132/-the-economic-value-of-vaccinations-a-systematic-review-of-italian-economic-evaluations-and-hta-reports
#17
Francesco Di Nardo, Sara Boccalini, Giovanna Elisa Calabrò, Andrea Marcellusi, Matteo Ruggeri, Paolo Bonanni, Raffaella Vitali, Eleonora Capannini, Francesco Saverio Mennini, Americo Cicchetti, Donatella Panatto, Roberto Gasparini, Walter Ricciardi, Chiara De Waure
INTRODUCTION: Decision-making in healthcare should rely on evidence-based approaches able to make possible a transparent and robust assessment of all the aspects related to health technologies. One of the assessment elements is represented by the efficiency that is the specific objective of economic evaluations and also of Health Technology Assessment (HTA). The collection and synthesis of evidence is the first indispensable step in order to foster a proper convey of scientific knowledge to the decision-makers...
September 2017: Igiene e Sanità Pubblica
https://www.readbyqxmd.com/read/29433128/-the-new-national-immunization-program-2017-2019-and-the-essential-care-levels-what-is-going-to-change
#18
Chiara De Waure, Leuconoe Grazia Sisti, Andrea Poscia, Walter Ricciardi
Italy is witnessing relevant challenges in the field of prevention and control of vaccine-preventable diseases. The worrying and growing phenomenon of "vaccine-hesitancy" has contributed to the reduction of vaccination coverage, undermining goals reached thanks to vaccines introduction. The new Italian National Immunization Plan (NIP) 2017-2019 and the update of the list of Essential Care Levels (LEA), approved in the current year, extend the vaccination offer based on the latest scientific evidence with the introduction of new vaccines and the enlargement of target population...
September 2017: Igiene e Sanità Pubblica
https://www.readbyqxmd.com/read/29432666/impact-of-rotavirus-vaccination-on-rotavirus-hospitalization-rates-among-a-resource-limited-rural-population-in-mbita-western-kenya
#19
Ernest Apondi Wandera, Shah Mohammad, Martin Bundi, James Nyangao, Amina Galata, Cyrus Kathiiko, Erick Odoyo, Sora Guyo, Gabriel Miring'u, Satoshi Komoto, Yoshio Ichinose
OBJECTIVES: A two-dose oral monovalent rotavirus vaccine (RV1) was introduced into the Kenyan National Immunization Program in July 2014. We assessed trends in hospitalization for rotavirus-specific acute gastroenteritis (AGE) and strain distribution among children <5 years in a rural, resource-limited setting in Kenya before and after the nationwide implementation of the vaccine. METHODS: Data on rotavirus AGE and strain distribution were derived from a five-year hospital-based surveillance...
February 12, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29429811/hospital-based-surveillance-for-rotavirus-diarrhea-in-ulaanbaatar-mongolia-april-2009-through-march-2016
#20
Altanchimeg Samdan, Sarangua Ganbold, Oyunchimeg Guntev, Solongo Orosoo, Narmandakh Javzandorj, Amar Gongor, Altansukh Enkhtuvshin, Sodbayar Demberelsuren, Wajid Abdul, Youngmee Jee, Varja Grabovac, Carl Kirkwood, Kimberley Fox, Batmunkh Nyambat
BACKGROUND: Diarrheal disease is one of the leading causes of illness and death in young children in the world, especially the developing countries. Diarrheal disease results in about half a million childhood death per year, ranking second among all causes worldwide. Diarrheal disease due to rotavirus infection is currently the most common cause of severe diarrhea in infants and young children worldwide. Rotavirus immunization of infants is a safe and effective public health intervention for rotavirus infection control and expected to lead to a reduction of childhood morbidity and mortality...
February 8, 2018: Vaccine
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