keyword
https://read.qxmd.com/read/38163518/pangenomics-a-new-era-in-the-field-of-neurodegenerative-diseases
#21
REVIEW
Paolo Abondio, Francesco Bruno, Giuseppe Passarino, Alberto Montesanto, Donata Luiselli
A pangenome is composed of all the genetic variability of a group of individuals, and its application to the study of neurodegenerative diseases may provide valuable insights into the underlying aspects of genetic heterogenetiy for these complex ailments, including gene expression, epigenetics, and translation mechanisms. Furthermore, a reference pangenome allows for the identification of previously undetected structural commonalities and differences among individuals, which may help in the diagnosis of a disease, support the prediction of what will happen over time (prognosis) and aid in developing novel treatments in the perspective of personalized medicine...
December 30, 2023: Ageing Research Reviews
https://read.qxmd.com/read/38148667/a-short-staff-training-system-for-behavioural-and-psychological-symptoms-of-dementia-in-care-facilities-based-on-functional-analysis-and-positive-behaviour-support-a-single-arm-pre-and-post-comparative-study
#22
JOURNAL ARTICLE
Dai Noguchi, Hiroaki Kazui, Katsuo Yamanaka
BACKGROUND: Work schedules can make it challenging for professional care workers to participate in long-term training programs on managing behavioural and psychological symptoms of dementia (BPSD). Simultaneously, it is necessary to prevent caregivers' negative responses to BPSD, provide a positive environment for people with dementia, and create a system for new management plans, since the initial one is often unsuccessful. Therefore, we developed a short manual-based training system for functional analysis including positive behaviour support and strategies when management plans do not function well...
December 26, 2023: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
https://read.qxmd.com/read/38143360/aberrant-cortical-activity-in-5xfad-mice-in-response-to-social-and-non-social-olfactory-stimuli
#23
JOURNAL ARTICLE
Filip Kosel, Mackenzie Rae Hartley, Tamara Brook Franklin
BACKGROUND: Neuroimaging studies investigating the behavioral and psychological symptoms of dementia (BPSD)- such as apathy, anxiety, and depression- have linked some of these symptoms with altered neural activity. However, inconsistencies in operational definitions and rating scales, limited scope of assessments, and poor temporal resolution of imaging techniques have hampered human studies. Many transgenic (Tg) mouse models of Alzheimer's disease (AD) exhibit BPSD-like behaviors concomitant with AD-related neuropathology, allowing examination of how neural activity may relate to BPSD-like behaviors with high temporal and spatial resolution...
December 19, 2023: Journal of Alzheimer's Disease: JAD
https://read.qxmd.com/read/38137710/association-between-gray-and-white-matter-lesions-and-its-involvement-in-clinical-symptoms-of-alzheimer-s-type-dementia
#24
JOURNAL ARTICLE
Taizen Nakase, Benjamin Thyreau, Yasuko Tatewaki, Naoki Tomita, Yumi Takano, Michiho Muranaka, Yasuyuki Taki
BACKGROUND: Not only gray matter lesions (GMLs) but also white matter lesions (WMLs) can play important roles in the pathology of Alzheimer's disease (AD). The progression of cognitive impairment (CI) and behavioral and psychological symptoms of dementia (BPSD) might be caused by a concerted effect of both GML and WML. OBJECTIVE: This study aimed to investigate the association between GML and WML and how they are involved in the symptoms of CI and BPSD in dementia patients by means of imaging technology...
December 12, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/38112608/salivary-cortisol-and-melatonin-sleep-and-behavioral-patterns-in-older-adults-living-with-dementia
#25
JOURNAL ARTICLE
Eunhee Cho, Hyangkyu Lee, Jinhee Shin, Sujin Kim, Seok-Jae Heo, Hyunki Park, Jo Woon Seok
BACKGROUND: Over half of the older adults living with dementia have behavioral and psychological symptoms of dementia (BPSD), including sleep disturbance; however, little is known about physiological markers. Salivary cortisol and melatonin have been identified as potential biomarkers of BPSD, with evidence suggesting a relationship between these biomarkers and various behavioral factors, as well as sleep and activity patterns. OBJECTIVES: To investigate the time-dependent changes in salivary cortisol and melatonin levels in older adults with dementia, their relationship with the sleep-wake cycle, and their correlation with BPSD symptoms and behavioral factors...
December 19, 2023: Nursing Research
https://read.qxmd.com/read/38106552/home-based-family-caregiver-delivered-music-and-reading-interventions-for-people-living-with-dementia-homeside-trial-an-international-randomised-controlled-trial
#26
JOURNAL ARTICLE
Felicity Anne Baker, Vanessa Pac Soo, Jodie Bloska, Laura Blauth, Anna A Bukowska, Libby Flynn, Ming Hung Hsu, Edyta Janus, Kjersti Johansson, Tone Kvamme, Nicola Lautenschlager, Hayley Miller, Jonathan Pool, Agnieszka Smrokowska-Reichmann, Karette Stensæth, Kate Teggelove, Sven Warnke, Thomas Wosch, Helen Odell-Miller, Karen Lamb, Sabine Braat, Tanara Vieira Sousa, Jeanette Tamplin
BACKGROUND: Music interventions provided by qualified therapists within residential aged care are effective at attenuating behavioural and psychological symptoms (BPSD) of people with dementia (PwD). The impact of music interventions on dementia symptom management when provided by family caregivers is unclear. METHODS: We implemented a community-based, large, pragmatic, international, superiority, single-masked randomised controlled trial to evaluate if caregiver-delivered music was superior to usual care alone (UC) on reducing BPSD of PwD measured by the Neuropsychiatric Inventory-Questionnaire (NPI-Q)...
November 2023: EClinicalMedicine
https://read.qxmd.com/read/38100598/an-integrated-model-of-psychosocial-correlates-of-insomnia-severity-in-family-caregivers-of-people-with-dementia
#27
JOURNAL ARTICLE
Lucía Jiménez-Gonzalo, Carlos Vara-García, Rosa Romero-Moreno, María Márquez-González, Javier Olazarán, Roland von Känel, Brent T Mausbach, Andrés Losada-Baltar
OBJECTIVES: Research has shown the relevance of stress and coping factors in explaining caregivers' insomnia symptoms. However, few attempts have been made to empirically test an integrative model for insomnia severity in family caregivers of people with dementia. The aim of this study was to test such a model, in which insomnia severity is proposed to be influenced by predisposing factors, precipitated by stressors, and perpetuated by behaviors to cope with these stressors. METHODS: 311 family caregivers of people with dementia were assessed for variables categorized as predisposing (e...
December 15, 2023: Aging & Mental Health
https://read.qxmd.com/read/38089174/behavioral-and-psychological-symptoms-of-dementia-in-the-long-term-care-setting-assessment-of-aged-adults-and-intervention-for-caregivers
#28
JOURNAL ARTICLE
Evelise Saia Rodolpho Duarte, Alessandro Ferrari Jacinto
UNLABELLED: Due to the progressive need for care, older adults with dementia are at risk of becoming institutionalized. Caregivers of these patients are tasked with the challenge of controlling behavioral and psychological symptoms without sufficient knowledge and are therefore at greater risk of developing physical and mental health problems. In this context, psychoeducational interventions can help greatly toward improving caregiver well-being. OBJECTIVE: to investigate the prevalence of behavioral and psychological symptoms of dementia (BPSD) in aged residents of long-term care facilities (LTCFs), to determine the prevalence of burden and common mental disorders in caregivers, and to assess the effects of a psychoeducational intervention...
2023: Dementia & Neuropsychologia
https://read.qxmd.com/read/38070931/differentiating-alzheimer-s-disease-from-mild-cognitive-impairment-a-quick-screening-tool-based-on-machine-learning
#29
JOURNAL ARTICLE
Wenqi Lü, Meiwei Zhang, Weihua Yu, Weihong Kuang, Lihua Chen, Wenbo Zhang, Juan Yu, Yang Lü
BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative disorder characterised by cognitive decline, behavioural and psychological symptoms of dementia (BPSD) and impairment of activities of daily living (ADL). Early differentiation of AD from mild cognitive impairment (MCI) is necessary. METHODS: A total of 458 patients newly diagnosed with AD and MCI were included. Eleven batteries were used to evaluate ADL, BPSD and cognitive function (ABC). Machine learning approaches including XGboost, classification and regression tree, Bayes, support vector machines and logical regression were used to build and verify the new tool...
December 9, 2023: BMJ Open
https://read.qxmd.com/read/38059250/guidelines-for-pharmacotherapy-in-alzheimer-s-disease-a-primer-on-fda-approved-drugs
#30
REVIEW
Ashvin Varadharajan, Aarjith Damian Davis, Aishwarya Ghosh, Tejaswini Jagtap, Anjo Xavier, Anjana Jayakumar Menon, Dwaiti Roy, Sandhya Gandhi, Thomas Gregor
The growing prevalence of dementia makes it important for us to better understand its pathophysiology and treatment modalities, to improve the quality of life of patients and caregivers. Alzheimer's disease (AD), a neurodegenerative disease, is the most common form of amnestic dementia in the geriatric population. Pathophysiology of AD is widely attributed to aggregation of amyloid-beta (Aβ) plaques and hyperphosphorylation of tau proteins. Initial treatment modalities aimed to increase brain perfusion in a non-specific manner...
2023: Journal of Neurosciences in Rural Practice
https://read.qxmd.com/read/38031345/development-and-validation-of-a-nutrition-related-genetic-clinical-radiological-nomogram-associated-with-behavioral-and-psychological-symptoms-in-alzheimer-s-disease
#31
JOURNAL ARTICLE
Jiwei Jiang, Yaou Liu, Anxin Wang, Zhizheng Zhuo, Hanping Shi, Xiaoli Zhang, Wenyi Li, Mengfan Sun, Shirui Jiang, Yanli Wang, Xinying Zou, Yuan Zhang, Ziyan Jia, Jun Xu
BACKGROUND: Few evidence is available in the early prediction models of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease (AD). This study aimed to develop and validate a novel genetic-clinical-radiological nomogram for evaluating BPSD in patients with AD and explore its underlying nutritional mechanism. METHODS: This retrospective study included 165 patients with AD from the Chinese Imaging, Biomarkers, and Lifestyle (CIBL) cohort between June 1, 2021, and March 31, 2022...
November 29, 2023: Chinese Medical Journal
https://read.qxmd.com/read/38025803/the-effectiveness-of-a-community-nurse-led-support-program-for-dementia-caregivers-in-chinese-communities-the-chongqing-ageing-and-dementia-study
#32
JOURNAL ARTICLE
Yuanyuan Ma, Juan Gong, Lingli Zeng, Qinghua Wang, Xiuqing Yao, Huiming Li, Yaozhi Chen, Feng Liu, Mengyuan Zhang, Hui Ren, Lily Dongxia Xiao, Yan Lian
BACKGROUND: As the primary caregivers for people with dementia in China, family caregivers face a significant care burden that can negatively impact their mental and physical health. It is vital to investigate ways to support these caregivers. OBJECTIVE: To assess the effectiveness of a program led by community nurses to support caregivers of individuals with dementia. METHODS: A total of 30 caregivers received nurse-led support in addition to usual care, while 28 caregivers received only usual care...
2023: JAD Reports
https://read.qxmd.com/read/38012101/comparative-efficacy-of-multiple-non-pharmacological-interventions-for-behavioural-and-psychological-symptoms-of-dementia-a-network-meta-analysis-of-randomised-controlled-trials
#33
REVIEW
Zihan Yin, Yaqin Li, Qiongnan Bao, Xinyue Zhang, Manze Xia, Wanqi Zhong, Kexin Wu, Jin Yao, Zhenghong Chen, Mingsheng Sun, Ling Zhao, Fanrong Liang
Non-pharmacological interventions can improve the behavioural and psychological symptoms of dementia (BPSD). However, the optimal non-pharmacological treatments remain controversial. This study aimed to compare the efficacy of multiple non-pharmacological methods and identify the optimal therapy for BPSD. Potential randomised controlled trials (RCTs) were searched and selected from 15 databases and sources from the inception of the databases until 1 October 2022. Two independent authors implemented study screening, data extraction, and methodological quality assessment...
November 27, 2023: International Journal of Mental Health Nursing
https://read.qxmd.com/read/38007648/effect-of-nordic-sensi%C3%A2-chair-on-behavioral-and-psychological-symptoms-of-dementia-in-nursing-homes-residents-a-randomized-controlled-trial
#34
JOURNAL ARTICLE
José María García-Alberca, María Dolores de la Rosa, Paloma Solo de Zaldívar, María Ledesma, Estela Oltra, Esther Gris, Olga Ocejo, Javier Torrecilla, Carmen Zafra, Ana Sánchez-Fernández, Tomás Mancilla, Mercedes López-Romero, Raquel Jerez, Nuria Santana, José Pablo Lara, Miguel Ángel Barbancho, Encarnación Blanco-Reina
BACKGROUND: Behavioral and psychological symptoms of dementia (BPSD) are present in most people with dementia (PwD), including Alzheimer's disease. There is consensus that non-pharmacological therapies represent the first line of treatment to address BPSD. OBJECTIVE: We explore the efficacy of the use of a rocking chair (Nordic Sensi® Chair, NSC) in the treatment of BPSD in nursing home residents with moderate and severe dementia. METHODS: We carried out a 16-week randomized, single-blind, controlled, clinical trial with PwD admitted to nursing homes...
November 21, 2023: Journal of Alzheimer's Disease: JAD
https://read.qxmd.com/read/37987697/temporal-patterns-of-behavioral-and-psychological-symptoms-of-dementia-and-caregiver-distress-associated-daily-and-individual-factors
#35
JOURNAL ARTICLE
Caitlin Connelly, Kyungmin Kim, Yin Liu, Steven H Zarit
This study examined daily occurrences of behavioral and psychological symptoms of dementia (BPSD) and whether caregivers' perceived distress towards BPSD varies throughout four phases of the day (i.e., morning, daytime, evening, and night). Family caregivers residing with relatives who were using adult day services (ADS) participated in an 8-day daily diary study (caregiver N = 173; caregiver-day N = 1,359). BPSD occurred most frequently in the evenings. ADS use, sleep disturbances, and dementia severity were significantly associated with BPSD occurrence for some phases of the day...
November 21, 2023: Journal of Applied Gerontology: the Official Journal of the Southern Gerontological Society
https://read.qxmd.com/read/37981054/neuropsychiatric-disturbances-in-mild-cognitive-impairment-a-scientometric-analysis
#36
REVIEW
Arisara Amrapala, Michel Sabé, Marco Solmi, Michael Maes
Behavioral and psychological symptoms of dementia (BPSD) have been extensively studied in dementia than its prodromal stage, known as mild cognitive impairment (MCI). A scientometric study on BPSD in MCI would be valuable in synthesizing the existing body of research and providing insights into the trends, networks, and influencers within this area. We searched for related literature in the Web of Science database and extracted complete text and citation records of each publication. The primary objective was to map the research evolution of BPSD in MCI and highlight dominant research themes...
December 2023: Ageing Research Reviews
https://read.qxmd.com/read/37952979/outpatient-rehabilitation-for-an-older-couple-in-a-repopulated-village-10-years-after-the-fukushima-nuclear-disaster-an-embedded-case-study
#37
JOURNAL ARTICLE
Yuta Saito, Sora Sato, Yoshitaka Nishikawa, Fumiya Oguro, Nobuaki Moriyama, Keiichiro Sato, Yurie Kobashi, Toyoaki Sawano, Akihiko Ozaki, Takeo Nakayama, Masaharu Tsubokura, Seiji Yasumura, Shohei Sakai
BackgroundLittle information is available on the role of community-based rehabilitation after a nuclear disaster. Here, we report the case of an older couple living in an area repopulated after the Fukushima nuclear disaster of 2011 who received outpatient rehabilitation.Case presentationAn 84-year-old woman underwent total hip arthroplasty (THA) after she fell and sustained a trochanteric fracture while caring for her husband with Alzheimer's disease. The 85-year-old husband experienced worsening behavioral and psychological symptoms of dementia (BPSD) following his wife's hospitalization...
November 11, 2023: Fukushima Journal of Medical Science
https://read.qxmd.com/read/37943780/protocol-for-deprescribing-and-care-to-reduce-antipsychotics-in-dementia-decade-a-hybrid-effectiveness-implementation-pilot-study
#38
JOURNAL ARTICLE
Kirstine Skov Benthien, Laura Victoria Jedig Lech, Hanne Birke, Sidsel Maria Jørgensen, Tina Andersen, Stine Vest Hansen, Jon Trærup Andersen, Kristian Karstoft, Michaela Schiøtz, Charlotte Vermehren
INTRODUCTION: Behavioural and psychological symptoms of dementia (BPSD) should only rarely and briefly be treated with antipsychotics. Despite recommendations to the contrary, the use of antipsychotics in nursing home residents with dementia is widespread and followed by serious adverse effects. Intervention studies on methods to reduce the use of antipsychotics in persons with dementia are few and needed. The aim of this protocol is to describe the rationale and content of the intervention DEprescribing and Care to reduce Antipsychotics in DEmentia (DECADE)-a hybrid effectiveness-implementation pilot study...
2023: PloS One
https://read.qxmd.com/read/37927262/respectful-caring-for-the-agitated-elderly-recage-a-multicentre-prospective-observational-study-to-evaluate-the-effectiveness-of-special-care-units-for-people-with-dementia
#39
MULTICENTER STUDY
Aline Mendes, Sverre Bergh, Bruno Mario Cesana, Ron Handels, Alfonso Ciccone, Emmanuel Cognat, Andrea Fabbo, Sara Fascendini, Giovanni B Frisoni, Lutz Froelich, Maria Cristina Jori, Patrizia Mecocci, Paola Merlo, Oliver Peters, Magdalini Tsolaki, Carlo Alberto Defanti
Behavioral and psychological symptoms of dementia (BPSD) bring complexity in the clinical management of people with dementia; therefore, it is important to evaluate different models of care, such as Special Care Units (SCU-B).∥Objective:To evaluate the SCU-B effectiveness toward alleviating BPSD and improving the quality of life (QoL) of patients and their caregivers.∥Methods:ReCAGE was a multicenter, controlled, longitudinal study where 508 patients with BPSD were enrolled in two cohorts: 262 patients from centers endowed with a SCU-B, and 246 from centers without SCU-B...
2023: Journal of Alzheimer's Disease: JAD
https://read.qxmd.com/read/37837999/using-academic-detailing-to-enhance-the-knowledge-skills-and-attitudes-of-clinicians-caring-for-persons-with-behavioral-and-psychological-symptoms-of-dementia
#40
JOURNAL ARTICLE
Art Walaszek, Tammi Albrecht, Molly Schroeder, Tamara J LeCaire, Stephanie Houston, Miguel Recinos, Cynthia M Carlsson
Behavioral and psychological symptoms of dementia (BPSD) are highly prevalent in long-term care settings. We sought to enhance the knowledge, skills, and attitudes of primary care clinicians caring for patients with BPSD through academic detailing, an evidence-based approach for persuading health care professionals to make changes in their practice. We implemented academic detailing among physicians and nurse practitioners in 2 primary care settings, one an urban center serving a largely Black community and another a rural center serving a largely White community, within primary care-integrated dementia diagnostic clinics...
October 11, 2023: Journal of the American Medical Directors Association
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