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optic coherent tomography

Ram Iyer, Farzana Nasrin, Elton See, Steven Mathews
Optical coherence tomography (OCT) is a non-invasive imaging technique used to study and understand internal structures of biological tissues such as the anterior chamber of the human eye. An interesting problem is the reconstruction of the shape of the biological tissue from OCT images, that is not only a good fit of the data but also respects the smoothness properties observed in the images. A similar problem arises in Magnetic Resonance Imaging (MRI). We cast the problem as a penalized weighted least squares regression with a penalty on the magnitude of the second derivative (Laplacian) of the surface...
October 19, 2016: IEEE Transactions on Medical Imaging
Md Akter Hussain, Alauddin Bhuiyan, Andrew Turpin, Chi D Luu, R Theodore Smith, Robyn H Guymer, Ramamohanarao Kotagiri
OBJECTIVE: We propose an effective, automatic method for identification of four retinal layer boundaries from the Spectral Domain Optical Coherence Tomography (SD-OCT) images in the presence and absence of pathologies and morphological changes due to disease. METHODS: The approach first finds an approximate location of three reference layers, and then uses these to bound the search space for the actual layers, which is achieved by modeling the problem as a graph and applying Dijkstra's shortest path algorithm...
October 19, 2016: IEEE Transactions on Bio-medical Engineering
Chunxia Peng, Wei Wang, Quangang Xu, Mo Yang, Huangfen Zhou, Shuo Zhao, Shihui Wei
PURPOSE: The aim of this study was to evaluate the differences between macular inner retinal layers and peripapillary retinal nerve fibre layer (pRNFL) thickness in Chinese patients with neuromyelitis spectrum optic neuritis (NMOSD-ON) and isolated optic neuritis (ION) with only one episode. METHODS: This cross-sectional study included 35 patients (35 eyes) with NMOSD-ON (NMO-IgG seropositive) and 46 patients (46 eyes) with ION after one episode. Spectral domain optical coherence tomography (SD-OCT) was used to quantify pRNFL, macular RNFL (mRNFL), ganglion cell and inner plexiform layers (GCIPL) and inner nuclear layer (INL) thickness using an automated algorithm...
October 24, 2016: Acta Ophthalmologica
Eren Çerman, Deniz Özarslan Özcan, Ebru Toker
PURPOSE: To evaluate possible risk factors leading to sterile corneal infiltrates following corneal collagen cross-linking (CXL). METHODS: A total of 588 eyes of 459 patients treated with Epi-off (n = 461) or Epi-on (n = 127) CXL were retrospectively evaluated. Risk factors, including preoperative blepharitis and vernal conjunctivitis, the postoperative use of topical non-steroidal anti-inflammatory drugs (NSAIDs), as well as Kmax and pachymetry measurements, were assessed...
October 24, 2016: Acta Ophthalmologica
Damjan Glavač, Martina Jarc-Vidmar, Katarina Vrabec, Metka Ravnik-Glavač, Ana Fakin, Marko Hawlina
PURPOSE: To determine the spectrum of BEST1 mutations and to study the phenotype in Slovenian families with Best vitelliform macular dystrophy (BVMD) to identify genotype-phenotype correlations. METHODS: Twenty patients from five families underwent the ophthalmological examination including electrooculogram (EOG; N = 17), fundus autofluorescence imaging (N = 16) and optical coherence tomography (N = 14). Mutational screening was performed by direct DNA sequencing of the BEST1 gene...
October 24, 2016: Acta Ophthalmologica
Stela Vujosevic, Tommaso Torresin, Silvia Bini, Enrica Convento, Elisabetta Pilotto, Raffaele Parrozzani, Edoardo Midena
PURPOSE: To evaluate changes of specific retinal imaging biomarkers [intraretinal hyper-reflective retinal spots: HRS ; subfoveal neuroretinal detachment: SND; and increased foveal autofluorescence: IFAF after intravitreal steroid or anti-vascular endothelial growth factor treatment in diabetic macular oedema (DME)] as possible indicators of retinal inflammatory condition. METHODS: Retrospective analysis of images and clinical charts of 49 eyes (49 patients) with DME treated with intravitreal dexamethasone (dexamethasone, 23 eyes) or intravitreal ranibizumab (ranibizumab, 26 eyes)...
October 24, 2016: Acta Ophthalmologica
Lydia Sauer, Sven Peters, Johanna Schmidt, Dietrich Schweitzer, Matthias Klemm, Lisa Ramm, Regine Augsten, Martin Hammer
PURPOSE: To investigate the impact of macular pigment (MP) on fundus autofluorescence (FAF) lifetimes in vivo by characterizing full-thickness idiopathic macular holes (MH) and macular pseudo-holes (MPH). METHODS: A total of 37 patients with MH and 52 with MPH were included. Using the fluorescence lifetime imaging ophthalmoscope (FLIO), based on a Heidelberg Engineering Spectralis system, a 30° retinal field was investigated. FAF decays were detected in a short (498-560 nm; ch1) and long (560-720 nm; ch2) wavelength channel...
October 24, 2016: Acta Ophthalmologica
Kristian Lundberg, Anna Stage Vergmann, Anders Højslet Vestergaard, Nina Jacobsen, Ernst Goldschmidt, Tunde Peto, Jakob Grauslund
No abstract text is available yet for this article.
October 24, 2016: Acta Ophthalmologica
Hsin-Hua Liu, Zheng He, Christine T O Nguyen, Algis J Vingrys, Bang V Bui
PURPOSE: This pilot study considered whether intraocular pressure (IOP) lowering could reverse ganglion cell dysfunction in a rat model of chronic ocular hypertension. METHODS: A circumlimbal suture was applied in one eye to induce ocular hypertension (n = 7) in Long-Evans rats. The contralateral eye served as an untreated control. After 8 weeks of IOP elevation the suture was removed to lower IOP for the remaining 7 weeks. Electroretinogram (ERG) and optical coherence tomography (OCT) were measured at baseline, 2, 4, 8, 12 and 15 weeks...
October 24, 2016: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
Yohei Sotomi, Pannipa Suwannasom, Patrick W Serruys, Yoshinobu Onuma
The advent of intracoronary stents greatly increased the safety and applicability of percutaneous coronary interventions. One of the drawbacks of drug eluting stents (DES) is the increased risk of late and very late stent thrombosis (ST). The risk of ST after the DES implantation were anticipated to be solved with the advent of fully biodegradable scaffolds which offers the possibility of transient scaffolding of the vessel to prevent acute vessel closure and recoil while also transiently eluting an antiproliferative drug to counteract the constrictive remodeling and excessive neointimal hyperplasia...
October 25, 2016: EuroIntervention
Ewa Langwinska-Wosko, Marta Skowronska, Tomasz Kmiec, Anna Czlonkowska
BACKGROUND: Mitochondrial membrane protein-associated neurodegeneration (MPAN) is an neurodegeneration with brain iron accumulation (NBIA) subtype with mutation of C19orf12. Optic atrophy is one of the core symptoms in almost all MPAN cases, but the detailed ophthalmologic features of MPAN patients have not yet been described. METHODS: All consecutive symptomatic, gene proven MPAN patients underwent a detailed ophthalmological examination: best corrected visual acuity (BCVA), slit lamp examination, dilated fundus examination, tonometry, optical coherent tomography (OCT) and electrophysiological examinations...
November 15, 2016: Journal of the Neurological Sciences
Michel van Lint, Kristien Hoornaert, Marcel P M Ten Tusscher
PURPOSE: Two Caucasian Belgian families were diagnosed with autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS). The ophthalmological findings in both ARSACS disease and carriers are described. METHODS: In addition to a complete ophthalmological assessment, in both patients and carriers, spectral-domain Optical Coherence Tomography scans of the peri-papillary retinal nerve fiber layer were performed. RESULTS: Molecular analysis revealed a missense mutation which has not been reported before...
November 15, 2016: Journal of the Neurological Sciences
Konstantin Huhn, Robert Lämmer, Hanna Zimmermann, Alexandra Lämmer, Anne Waschbisch, Kathrin Utz, René Markus Gieß, Friedemann Paul, Ralf A Linker, De-Hyung Lee
BACKGROUND: Multiple Sclerosis (MS) is a chronic inflammatory disease of the CNS typically affecting younger adults and resulting in neuro-axonal degeneration already at early stages of the disease. Less is known about the effects of a later disease onset (LOMS, onset >50years of age). Analysis of retinal layers by optical coherence tomography (OCT) is a non-invasive method to investigate retinal and neuro-axonal degeneration. We applied OCT to detect differences in retinal damage depending on a later disease manifestation...
November 15, 2016: Journal of the Neurological Sciences
Abdulkadir Tunç, Belma Doğan Güngen, Ferhat Evliyaoğlu, Yeşim Güzey Aras, Aysel Kaya Tekeşin
The aim of this study was to investigate retinal nerve fiber layer (RNFL), ganglion cell layer (GCL) thickness, macular changes (central subfield thickness (CST), cube average thickness (CAT), cube volume (CV) in patients with migraine using spectral-domain optical coherence tomography (OCT) and to assess if there was any correlation with white matter lesions (WML). In this prospective case-control study, RNFL, GCL thickness and macular changes of 19 migraine patients with aura (MA), 41 migraine without aura (MO) and 60 age- and gender-matched healthy subjects were measured using OCT device...
October 21, 2016: Acta Neurologica Belgica
Min Hee Suh, Linda M Zangwill, Patricia Isabel C Manalastas, Akram Belghith, Adeleh Yarmohammadi, Felipe A Medeiros, Alberto Diniz-Filho, Luke J Saunders, Robert N Weinreb
PURPOSE: To investigate factors associated with dropout of the parapapillary deep retinal layer microvasculature assessed by optical coherence tomography angiography (OCTA) in glaucomatous eyes. DESIGN: Cross-sectional study. PARTICIPANTS: Seventy-one eyes from 71 primary open-angle glaucoma (POAG) patients with β-zone parapapillary atrophy (βPPA) enrolled in the Diagnostic Innovations in Glaucoma Study. METHODS: Parapapillary deep-layer microvasculature dropout was defined as a complete loss of the microvasculature located within the deep retinal layer of the βPPA from OCTA-derived optic nerve head vessel density maps by standardized qualitative assessment...
October 18, 2016: Ophthalmology
Mira M Sachdeva, Frederick A Jakobiec, Anna M Stagner, Athanasios Papakostas, Dean Eliott
PURPOSE: Large relaxing retinectomies have become increasingly used in the repair of retinal detachment related to proliferative vitreoretinopathy (PVR). Retinectomies expose the retinal pigment epithelium (RPE) to the vitreous cavity; the direct effects of silicone oil on the RPE are only beginning to be understood. DESIGN: Retrospective case series. PARTICIPANTS: Twelve patients noted to develop pigmented epiretinal deposits at regularly scheduled follow-up visits after repair of complex retinal detachments using silicone oil tamponade and retinectomy...
October 18, 2016: Ophthalmology
So Goto, Naoyuki Maeda, Shizuka Koh, Kazuhiko Ohnuma, Kenichi Hayashi, Ikko Iehisa, Toru Noda, Kohji Nishida
PURPOSE: To evaluate the accuracy of a new formula for predicting postoperative anterior chamber depth (ACD) with preoperative angle-to-angle (ATA) depth using anterior segment (AS) optical coherence tomography (OCT) and to compare it with established methods. DESIGN: Retrospective consecutive case series. PARTICIPANTS: Three hundred four eyes (276 patients) implanted with acrylic intraocular lenses (IOLs) were divided randomly into a training set (152 eyes) and a validation set (152 eyes)...
October 18, 2016: Ophthalmology
W Zbiba, A Baba, E Bouayed, A Daldoul
PURPOSE: Analyze the characteristics of fundus autofluorescence of diabetic macular edema and study the association between these characteristics and visual function. PATIENTS AND METHODS: Our study included 18 patients (28 eyes) with clinically significant diabetic macular edema. All patients had a complete eye examination with a fundus autofluorescence imaging and optical coherence tomography. The central macular thickness and central macular volume were measured...
October 18, 2016: Journal Français D'ophtalmologie
L Porrúa, N Oblanca, J J González-López
CASE REPORT: A 14 year-old boy attended our clinic complaining of a scotoma after an accidental exposure to a 10W, 450nm laser beam from a blue-light handheld laser device. Optical coherence tomography confirmed a full thickness macular hole. As visual acuity (VA) remained 20/20 Snellen, observation was decided. Spontaneous closure was confirmed after one month. DISCUSSION: Reckless use of high-power handheld laser devices may induce severe retinal lesions, including full thickness macular holes...
October 18, 2016: Archivos de la Sociedad Española de Oftalmología
Xinbo Gao, Wenbin Huang, Wei Wang, Minwen Zhou, Jiawei Wang, Shaolin Du, Shida Chen, Xiulan Zhang
OBJECTIVE: To characterize and compare the topographic profile of choroid in eyes after acute primary angle-closure (APAC) and in normal controls. DESIGN, SETTING, AND PARTICIPANTS: A prospective observational study was conducted. Forty-four consecutive patients who had experienced unilateral APAC that was resolved by treatment were recruited. Seventy age- and sex-matched normal individuals were recruited as controls. METHODS: Enhanced depth imaging-optical coherence tomography was used to measure choroidal thickness (CT) in 9 diffuse locations of macular region...
October 2016: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
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