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optic coherent tomography

Anna C S Tan, Kunal K Dansingani, Christine A Curcio, K Bailey Freund
No abstract text is available yet for this article.
December 1, 2017: Investigative Ophthalmology & Visual Science
Alessandro Marchese, Giuseppe Querques
No abstract text is available yet for this article.
December 1, 2017: Investigative Ophthalmology & Visual Science
Chris Y Wu, Michael E Jansen, Jorge Andrade, Toco Y P Chui, Anna T Do, Richard B Rosen, Avnish Deobhakta
Importance: Solar retinopathy is a rare form of retinal injury that occurs after direct sungazing. Objective: To enhance understanding of the structural changes that occur in solar retinopathy by obtaining high-resolution in vivo en face images. Design, Setting, and Participant: Case report of a young adult woman who presented to the New York Eye and Ear Infirmary with symptoms of acute solar retinopathy after viewing the solar eclipse on August 21, 2017...
December 7, 2017: JAMA Ophthalmology
Séverine Coquoz, Arno Bouwens, Paul J Marchand, Jérôme Extermann, Theo Lasser
Optical coherence microscopy (OCM) is an interferometric technique providing 3D images of biological samples with micrometric resolution and penetration depth of several hundreds of micrometers. OCM differs from optical coherence tomography (OCT) in that it uses a high numerical aperture (NA) objective to achieve high lateral resolution. However, the high NA also reduces the depth-of-field (DOF), scaling with 1/NA2. Interferometric synthetic aperture microscopy (ISAM) is a computed imaging technique providing a solution to this trade-off between resolution and DOF...
November 27, 2017: Optics Express
Azusa Kominami, Shinji Ueno, Taro Kominami, Ayami Nakanishi, Yasuki Ito, Kaoru Fujinami, Kazushige Tsunoda, Takaaki Hayashi, Sachiko Kikuchi, Shuhei Kameya, Takeshi Iwata, Hiroko Terasaki
BACKGROUND: Biallelic variants of POC1B were recently reported to cause autosomal recessive non-syndromic cone dystrophy. However, the number of studies supporting this is limited, and the clinical phenotypes of cone dystrophy have not been definitively determined. The purpose of this study was to report the phenotype of a case of POC1B-associated cone dystrophy. MATERIALS AND METHODS: The medical chart of one case diagnosed with cone dystrophy was reviewed. RESULTS: The patient was a 20-year-old Japanese man whose chief complaint was a progressive decrease in his central vision...
December 8, 2017: Ophthalmic Genetics
Guo Huang, Junchao Peng, Zi Ye, Aize Kijlstra, Donglei Zhang, Peizeng Yang
PURPOSE: To investigate fundus abnormalities in Vogt-Koyanagi-Harada (VKH) disease by a noninvasive tool, multispectral imaging (MSI). METHODS: A total of 77 patients with VKH and 163 healthy controls were enrolled between January and April 2015. The MSI findings were evaluated in combination with fundus fluorescein angiography (FFA), optical coherent tomography (OCT) and fundus photography (FP). Additionally, we compared extent of exposure of choroidal blood vessels between patients with VKH and healthy controls to evaluate retinal transmission function...
December 8, 2017: Acta Ophthalmologica
E Philippakis, M Legrand, M El Sanharawi, A Erginay, A Couturier, R Tadayoni
PurposeTo assess the feasibility and interest of measuring macular hole (MH) size using en face optical coherence tomography (OCT) compared with manual diameter measurements on B-scans.MethodsAmong our previously published series of 100 patients operated for primary MH, patients whose images were acquired with Cirrus 5000 HD-OCT (Carl Zeiss Meditec) with a quality signal strength >5/10 were included. Three segmentations (internal limiting membrane, horizontal, and retinal pigment epithelium (RPE)) were compared for obtaining the most appropriate en face image...
December 8, 2017: Eye
A Vincent, A AlAli, H MacDonald, C VandenHoven, E Héon
PurposeTo describe the ocular and systemic phenotype in IQCB1-related disease.MethodsFour cases (3 males, 1 female) with molecularly confirmed IQCB1-related disease underwent ophthalmological examination including best-corrected visual acuity (BCVA) measurement, fundus evaluation, electroretinography (ERG), and spectral-domain optical coherence tomography (SD-OCT). Systemic evaluation including abdominal ultrasound was performed in all cases.ResultsBCVA ranged from perception of light (Case-2; 1 year) to 20/125 (Case-1; 9 years)...
December 8, 2017: Eye
William J Cunningham, Chandrakumar Balaratnasingam, Yi Chen, Fred K Chen
BACKGROUND/PURPOSE: To report a case of cuticular drusen in an indigenous Australian. METHODS: A 37-year-old indigenous (aboriginal) Australian woman from a remote Western Australian town presented with a 2-month history of vision loss. Clinical history, examination, and multimodal retinal imaging data from spectral domain optical coherence tomography, fundus autofluorescence, fluorescein angiography, and indocyanine green angiography were analyzed. RESULTS: Multimodal imaging confirmed cuticular drusen complicated by a right choroidal neovascularization with pigment epithelial detachment and a left foveal vitelliform lesion...
December 5, 2017: Retinal Cases & Brief Reports
Xiao Shu, Lisa Beckmann, Hao Zhang
Visible-light optical coherence tomography (vis-OCT) is an emerging imaging modality, providing new capabilities in both anatomical and functional imaging of biological tissue. It relies on visible light illumination, whereas most commercial and investigational OCTs use near-infrared light. As a result, vis-OCT requires different considerations in engineering design and implementation but brings unique potential benefits to both fundamental research and clinical care of several diseases. Here, we intend to provide a summary of the development of vis-OCT and its demonstrated applications...
December 2017: Journal of Biomedical Optics
Daniel Velazquez-Villoria, Analia Azaro, Jordi Rodon, Cinta Hierro, Danai Kyriakou, Jose Garcia-Arumi, Miguel Angel Zapata
AIMS: To describe novel ocular toxicity in patients with metastatic cancer undergoing chemotherapy with fibroblast growth factor receptor (FGFR) inhibitors. METHODS: This observational case series study included five patients with advanced cancer who received selected pan-FGFR inhibitors as single chemotherapy in the framework of a dose-finding study and phase I and phase II clinical studies. In all cases, subfoveal neurosensory retinal detachment was diagnosed...
December 7, 2017: British Journal of Ophthalmology
Naif S Sannan, Cheryl Y Gregory-Evans, Christopher J Lyons, Anna M Lehman, Sylvie Langlois, Simon J Warner, Helen Zakrzewski, Kevin Gregory-Evans
OBJECTIVE: To describe the clinical presentation and genotype of subjects with aniridia with a particular focus on foveal hypoplasia. DESIGN: Prospective cohort study. PARTICIPANTS: Thirty-three Canadian participants with aniridia and of various ethnic backgrounds residing in British Columbia. METHODS: Full ophthalmic examinations and posterior segment spectral domain-optical coherence tomography (SD-OCT) imaging were performed...
December 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
Akiko Maehara, Mitsuaki Matsumura, Ziad A Ali, Gary S Mintz, Gregg W Stone
Procedural guidance with intravascular ultrasound (IVUS) imaging improves the clinical outcomes of patients undergoing percutaneous coronary intervention (PCI) by: 1) informing the necessity for lesion preparation; 2) directing appropriate stent sizing to maximize the final stent area and minimize geographic miss; 3) selecting the optimal stent length to cover residual disease adjacent to the lesion, thus minimizing geographic miss; 4) guiding optimal stent expansion; 5) identifying acute complications (edge dissection, stent malapposition, tissue protrusion); and 6) clarifying the mechanism of late stent failure (stent thrombosis, neointimal hyperplasia, stent underexpansion or fracture, or neoatherosclerosis)...
December 2017: JACC. Cardiovascular Imaging
Meiyan Li, Dong Yang, Yingjun Chen, Meng Li, Tian Han, Xingtao Zhou, Katherine Ni
BACKGROUND: To report a first case of late-onset diffuse lamellar keratitis (DLK) occurring 4 years after femtosecond laser-assisted small incision lenticule extraction (SMILE). CASE PRESENTATION: A 41-year-old man who underwent SMILE 4 years prior developed DLK in the right eye 1 day after he was struck in the eye by a finger while playing with his son. Slim-lamp microscopy and anterior segment optical coherence tomography (AS-OCT) were used to evaluate the cornea of the right eye...
December 8, 2017: BMC Ophthalmology
J M Abalo-Lojo, A Treus, M Arias, F Gómez-Ulla, F Gonzalez
PURPOSE: To analyze the changes in retinal nerve fiber layer (RNFL) in eyes with and without prior history of optic neuritis (ON) of patients with multiple sclerosis (MS) after a 5-year time period (2010-2015) using optical coherence tomography. METHODS: The RNFL thickness of 114 eyes of 57 MS patients and 40 eyes of 20 healthy subjects were measured in year 2010 and year 2015. Measurements were made separately in twelve sectors around the optic nerve head. Statistical comparisons were made with the obtained data...
November 22, 2017: Multiple Sclerosis and related Disorders
Yuki Matsuhashi, Kei Sameshima, Yoshiki Yamamoto, Mitsuo Umezu, Kiyotaka Iwasaki
BACKGROUND: Blood-contacting devices have contributed to improving the treatment of patients. However, thrombus formation at the interface between a connector and tube is still a potential source of thrombus-related complications that induce stroke or myocardial infarction. We aimed to develop a non-blood-contacting real-time method for visualizing thrombus formation, and to experimentally investigate the time-dependent phenomenon of thrombus formation at the interface between a connector and a tube in a medical device...
2017: PloS One
Hyeon-Cheol Park, Jessica Mavadia-Shukla, Wu Yuan, Milad Alemohammad, Xingde Li
We report the development of a broadband rotary joint for high-speed ultrahigh-resolution endoscopic optical coherence tomography (OCT) imaging in the 800 nm spectral range. This rotary joint features a pair of achromatic doublets in order to achieve broadband operation for a 3 dB bandwidth over 150 nm. The measured one-way throughput of the rotary joint is greater than 80%, while the fluctuation of the double-pass coupling efficiency during 360 deg rotation is less than ±5% at a near video-rate speed of 20 revolutions/s (rps)...
December 1, 2017: Optics Letters
Peijun Tang, Shaojie Liu, Junbo Chen, Zhiling Yuan, Bingkai Xie, Jianhua Zhou, Zhilie Tang
We developed a cross-correlation photothermal optical coherence tomography (CC-PTOCT) system for photothermal imaging with high lateral and axial resolution. The CC-PTOCT system consists of a phase-sensitive OCT system, a modulated pumping laser, and a digital cross-correlator. The pumping laser was used to induce the photothermal effect in the sample, causing a slight phase modulation of the OCT signals. A spatial phase differentiation method was employed to reduce phase accumulation. The noise brought by the phase differentiation method and the strong background noise were suppressed efficiently by the cross-correlator, which was utilized to extract the photothermal signals from the modulated signals...
December 1, 2017: Optics Letters
Peng Li, Zhiyu Huang, Shanshan Yang, Xi Liu, Qiushi Ren, Pei Li
In this Letter, we propose an adaptive digital classifier for flow contrast enhancement in optical coherence tomography angiography (OCTA). To solve the depth dependence in the initial motion-based classification, a depth-adaptive motion threshold was determined by performing a histogram analysis of an en-face image at each depth and identifying the static and dynamic voxel populations through fitting. In the follow-up shape-based classification, to adapt to the deformed vessel shapes in OCTA, a modified vesselness function along with an anisotropic Gaussian probe kernel was defined, and then a three-dimensional (3D) Hessian analysis-based shape filtering was utilized for effectively removing the residual static voxels...
December 1, 2017: Optics Letters
Lotte Themstrup, Nathalie De Carvalho, Sabrina Mai Nielsen, Jonas Olsen, Silvana Ciardo, Sandra Schuh, Birgit Meinecke-Hansen Nørnberg, Julia Welzel, Martina Ulrich, Giovanni Pellacani, Gregor B E Jemec
BACKGROUND: The subtype of basal cell carcinoma (BCC) influences the choice of treatment. Optical coherence tomography (OCT) is a non-invasive imaging tool and recent development of angiographic version of OCT has extended the application of OCT to image the cutaneous microvasculature (so called dynamic OCT, D-OCT). This study explores D-OCT's ability to differentiate the common BCC subtypes by microvascular and structural imaging. METHODS: 81 patients with 98 BCC lesions, consisting of three subtypes: 27 superficial BCC (sBCC), 55 nodular BCC (nBCC) and 16 infiltrative BCC (iBCC), were D-OCT scanned at three European dermatology centres...
December 7, 2017: Experimental Dermatology
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