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Rotavirus vaccine

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https://www.readbyqxmd.com/read/28627832/molecular-epidemiological-traits-of-group-a-rotaviruses-in-japanese-children-during-transitional-period-of-rotavirus-vaccine-implementation-2011-2014
#1
Sayaka Takanashi, Aksara Thongprachum, Shoko Okitsu, Shuichi Nishimura, Masaaki Kobayashi, Hideaki Kikuta, Atsuko Yamamoto, Kumiko Sugita, Tsuneyoshi Baba, Satoshi Hayakawa, Masashi Mizuguchi, Hiroshi Ushijima
BACKGROUND: Group A rotavirus (RVA) vaccines have been introduced in Japan since 2011. To investigate the molecular epidemiological traits of RVA during the transitional period of rotavirus vaccine implementation in Japan, this study was undertaken by following up three-decade long surveillance conducted in the same regions. METHODS: RVA were screened and genotyped by RT-PCR from diarrheal samples collected from non-hospitalized patients in six localities (Hokkaido, Tokyo, Shizuoka, Osaka, Kyoto, and Saga) during 2011 - 2014...
May 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28627429/impact-of-rotavirus-vaccination-on-child-mortality-morbidity-and-rotavirus-related-hospitalizations-in-bolivia
#2
Lucia Inchauste, Maritza Patzi, Kjetil Halvorsen, Susana Solano, Raul Montesano, Volga Iñiguez
BACKGROUND: The public health impact of rotavirus vaccination in countries with high child mortality rates remains to be established. RV1 rotavirus vaccine was introduced in Bolivia in August 2008. We describe trends in deaths, hospitalizations and healthcare visits due to acute gastroenteritis (AGE) and in rotavirus-related hospitalizations, among children <5 years of age, during pre and post-vaccination periods. METHODS: Data was obtained from the National Health Information System to calculate vaccine coverage and AGE-related health indicators...
June 13, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28623456/pertussis-and-rotavirus-vaccines-controversies-and-solutions
#3
REVIEW
Nabaneeta Dash, Sanjay Verma
Pertussis and rotavirus vaccines have been the subject of several controversies over the years. In this paper the authors discuss facts and myths behind these controversies and also suggest solutions to overcome some limitations of these vaccines. The whole-cell pertussis vaccine (wPV) came into disrepute due to the associated adverse reactions, resulting in its replacement by acellular pertussis vaccine (aPV) in industrialized nations in 1990s. Although wPV is known to have more side effects; but they are usually minor...
June 16, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28623028/impact-and-cost-effectiveness-of-rotavirus-vaccination-in-bangladesh
#4
Clint Pecenka, Umesh Parashar, Jacqueline E Tate, Jahangir A M Khan, Devin Groman, Stephen Chacko, Md Shamsuzzaman, Andrew Clark, Deborah Atherly
INTRODUCTION: Diarrheal disease is a leading cause of child mortality globally, and rotavirus is responsible for more than a third of those deaths. Despite substantial decreases, the number of rotavirus deaths in children under five was 215,000 per year in 2013. Of these deaths, approximately 41% occurred in Asia and 3% of those in Bangladesh. While Bangladesh has yet to introduce rotavirus vaccination, the country applied for Gavi support and plans to introduce it in 2018. This analysis evaluates the impact and cost-effectiveness of rotavirus vaccination in Bangladesh and provides estimates of the costs of the vaccination program to help inform decision-makers and international partners...
June 13, 2017: Vaccine
https://www.readbyqxmd.com/read/28620404/oral-administration-of-a-seed-based-bivalent-rotavirus-vaccine-containing-vp6-and-nsp4-induces-specific-immune-responses-in-mice
#5
Hao Feng, Xin Li, Weibin Song, Mei Duan, Hong Chen, Tao Wang, Jiangli Dong
Rotavirus is the leading cause of severe diarrheal disease among newborns. Plant-based rotavirus vaccines have been developed in recent years and have been proven to be effective in animal models. In the present study, we report a bivalent vaccine candidate expressing rotavirus subunits VP6 and NSP4 fused with the adjuvant subunit B of E. coli heat-labile enterotoxin (LTB) in maize seeds. The RT-PCR and Western blot results showed that VP6 and LTB-NSP4 antigens were expressed and accumulated in maize seeds...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28609219/parents-insights-after-pediatric-hospitalization-due-to-rotavirus-gastroenteritis-in-italy
#6
Federico Marchetti, Volker Vetter, Giorgio Conforti, Susanna Esposito, Paolo Bonanni
Most of the severe cases of acute gastroenteritis in infants and children under five globally are caused by rotavirus infection. There are nearly 15,000 rotavirus gastroenteritis (RVGE) hospitalizations in Italy each year, which could be reduced by available rotavirus vaccines. In addition to the economic and societal burden, RVGE hospitalization could impact families negatively. The aim of this survey was to obtain parents' insights after hospitalization of their child for RVGE. Parents, of 500 children aged 0-5 years, were interviewed about their experience of RVGE hospitalization and asked to rate their stress on different items and overall...
June 13, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28606817/phylogenetic-analysis-of-g1p-8-and-g12p-8-rotavirus-a-samples-obtained-in-the-pre-and-post-vaccine-periods-and-molecular-modeling-of-vp4-and-vp7-proteins
#7
Tâmera Nunes Vieira Almeida, Teresinha Teixeira de Sousa, Roosevelt Alves da Silva, Fabíola Souza Fiaccadori, Menira Souza, Kareem Rady Badr, Divina das Dôres de Paula Cardoso
Reduction in morbimortality rates for acute gastroenteritis (AGE) by Rotavirus A (RVA) has been observed after the introduction of vaccines, however the agent continues to circulate. The present study described the genomic characterization of the 11 dsRNA segments of two RVA samples G1P[8] obtained in the pre- and post-vaccination periods and one of G12P[8] sample (post-vaccine), compared to Rotarix™ vaccine. Analysis by molecular sequencing of the samples showed that the three samples belonged to genogroup I...
June 9, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28604328/the-status-of-vaccine-availability-and-associated-factors-in-tshwane-government-clinics
#8
Ntombenhle Judith Ngcobo, Mercy G Kamupira
BACKGROUND: Vaccines have greatly contributed to the control of vaccine-preventable diseases and to human development. Efforts by many countries to introduce new vaccines are a significant move towards achieving the sustainable development goal for health. However, effective vaccine supply chains that ensure an uninterrupted supply of vaccines are pivotal to attaining universal access to life-saving vaccines and sustainable development. The introduction of new vaccines puts a strain on supply chains; South Africa (SA) is no exception, as there are indications of vaccine stock-outs in clinics...
May 24, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28592985/child-feeding-practices-and-diarrheal-disease-among-children-less-than-two-years-of-age-of-the-nomadic-people-in-hadaleala-district-afar-region-northeast-ethiopia
#9
Zemichael Gizaw, Wondwoson Woldu, Bikes Destaw Bitew
BACKGROUND: Diarrhea is a serious public health problem in Ethiopia. It is responsible for 24-30% of all infant deaths and there is a lack of evidence on the health burdens among the nomadic people. This study was therefore designed to assess the prevalence of diarrhea among children less thanvtwo year's of age and its association with feeding practices among the nomadic people in Hadaleala district, northeast Ethiopia. METHODS: A cross-sectional study was conducted in Hadaleala district...
2017: International Breastfeeding Journal
https://www.readbyqxmd.com/read/28591681/structural-features-of-glycan-recognition-among-viral-pathogens
#10
REVIEW
Sreejesh Shanker, Liya Hu, Sasirekha Ramani, Robert L Atmar, Mary K Estes, B V Venkataram Prasad
Recognition and binding to host glycans present on cellular surfaces is an initial and critical step in viral entry. Diverse families of host glycans such as histo-blood group antigens, sialoglycans and glycosaminoglycans are recognized by viruses. Glycan binding determines virus-host specificity, tissue tropism, pathogenesis and potential for interspecies transmission. Viruses including noroviruses, rotaviruses, enteroviruses, influenza, and papillomaviruses have evolved novel strategies to bind specific glycans often in a strain-specific manner...
June 4, 2017: Current Opinion in Structural Biology
https://www.readbyqxmd.com/read/28583305/immunogenicity-and-safety-of-a-new-hexavalent-vaccine-dtap5-ipv-hb-hib-administered-in-a-mixed-primary-series-schedule-with-a-pentavalent-vaccine-dtap5-ipv-hib
#11
Federico Martinón-Torres, Florence Boisnard, Stéphane Thomas, Christine Sadorge, Ray Borrow
DTaP5-IPV-HB-Hib vaccine is a fully-liquid, combination hexavalent vaccine. This phase III, open-label, multicentre study conducted in Spain, evaluated the immune response to all DTaP5-IPV-HB-Hib antigens when the vaccine was used in a mixed hexa/penta/hexa primary series. Infants (who had received one dose of hepatitis B vaccine at birth) received a mixed schedule including DTaP5-IPV-HB-Hib (PRP-OMP conjugate) at 2 and 6months of age, DTaP5-IPV-Hib at 4months, meningococcal serogroup C conjugate (MCC) vaccine at 2 and 4months, and routine rotavirus and pneumococcal vaccination...
June 2, 2017: Vaccine
https://www.readbyqxmd.com/read/28582541/epidemiology-of-rotavirus-infection-in-children-from-a-rural-and-urban-area-in-maputo-southern-mozambique-before-vaccine-introduction
#12
Nilsa de Deus, Eva João, Assa Cuamba, Marta Cassocera, Leopoldina Luís, Sozinho Acácio, Inácio Mandomando, Orvalho Augusto, Nicola Page
This study aimed to describe the epidemiology of rotavirus infections in Mozambique before vaccine introduction. Between February 2012 and September 2013, stool specimens, demographic and clinical data were collected from 384 children <5 years old hospitalized with acute diarrhea in Mavalane General Hospital and Manhiça District Hospital, southern Mozambique. The samples were tested for rotavirus A using enzyme-linked immunosorbent assay. The overall prevalence of rotavirus infection was 42.4% [95% confidence interval (95CI): 37...
June 5, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/28575304/impact-of-rotavirus-vaccine-introduction-and-post-introduction-etiology-of-diarrhea-requiring-hospital-admission-in-haydom-tanzania-a-rural-african-setting
#13
James A Platts-Mills, Caroline Amour, Jean Gratz, Rosemary Nshama, Thomas Walongo, Buliga Mujaga, Athanasia Maro, Timothy L McMurry, Jie Liu, Estomih Mduma, Eric R Houpt
Background: No data are available on the etiology of diarrhea requiring hospitalization after rotavirus vaccine introduction in Africa. The monovalent rotavirus vaccine was introduced in Tanzania on January 1, 2013. We performed a vaccine impact and effectiveness study as well as a qPCR-based etiology study at a rural Tanzanian hospital. Methods: We obtained data on admissions among children under 5 years to Haydom Lutheran Hospital between January 1, 2010 and December 31, 2015, and estimated the impact of vaccine introduction on all-cause diarrhea admissions...
May 29, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28567431/rotavirus-vaccine-schedules-and-vaccine-response-among-infants-in-low-and-middle-income-countries-a-systematic-review
#14
REVIEW
Joann F Gruber, Lucinda M Gruber, Rachel Palmieri Weber, Sylvia Becker-Dreps, Michele Jonsson Funk
BACKGROUND: Rotavirus vaccine schedules may impact vaccine response among children in low- and middle-income countries (LMICs). Our objective was to review the literature evaluating the effects of monovalent (RV1) or pentavalent rotavirus vaccines schedules on vaccine response. METHODS: We searched PubMed, Web of Science, Embase, and ClinicalTrials.gov for eligible trials conducted in LMICs comparing ≥2 vaccine schedules and reporting immunologic response or efficacy...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28560356/rotavac-%C3%A2-does-not-interfere-with-the-immune-response-to-childhood-vaccines-in-indian-infants-a-randomized-placebo-controlled-trial
#15
Temsunaro Rongsen Chandola, Sunita Taneja, Nidhi Goyal, Kalpana Antony, Kiran Bhatia, Deepak More, Nita Bhandari, Iksung Cho, Krishna Mohan, Sai Prasad, Gvja Harshavardhan, Tataji Surender Rao, Sudhanshu Vrati, Maharaj Kishan Bhan
A phase III randomized double-blind placebo-controlled trial was conducted in the urban neighborhoods of Delhi to assess whether Oral Rotavirus Vaccine ROTAVAC(®) interferes with the immune response to childhood vaccines when coadministered. Infants aged 6 weeks were randomized to receive three doses of either ROTAVAC(®) or placebo along with childhood vaccines: Oral Polio Vaccine and vaccines against Diphtheria, Pertussis, Tetanus, Hepatitis B and Haemophilus influenza type b given as Pentavalent at 6, 10, 14 weeks of age...
May 2017: Heliyon
https://www.readbyqxmd.com/read/28545926/lost-workdays-and-healthcare-use-before-and-after-hospital-visits-due-to-rotavirus-and-other-gastroenteritis-among-young-children-in-norway
#16
Christina H Edwards, Terese Bekkevold, Elmira Flem
BACKGROUND: Cost-effectiveness of rotavirus vaccination is affected by assumptions used in health economic evaluations. To inform such evaluations, we assessed healthcare use before and after hospitalisations due to rotavirus and other acute gastroenteritis (AGE) among children <5years of age in Norway and estimated daycare and work absenteeism. METHODS: We conducted post-discharge interviews with caregivers of 282 children hospitalised with AGE at two hospitals in Norway during April 2014-February 2017...
May 22, 2017: Vaccine
https://www.readbyqxmd.com/read/28536027/live-attenuated-tetravalent-g1-g4-bovine-human-reassortant-rotavirus-vaccine-brv-tv-randomized-controlled-phase-iii-study-in-indian-infants
#17
Tarun Saluja, Sonali Palkar, Puneet Misra, Madhu Gupta, Potula Venugopal, Ashwani Kumar Sood, Ravi Mandyam Dhati, Avinash Shetty, Sangappa Malappa Dhaded, Sharad Agarkhedkar, Amlan Choudhury, Ramesh Kumar, Sundaram Balasubramanian, Sudhir Babji, Lopa Adhikary, Martin Dupuy, Sangeet Mohan Chadha, Forum Desai, Darshna Kukian, Badri Narayan Patnaik, Mandeep Singh Dhingra
BACKGROUND: Rotavirus remains the leading cause of diarrhoea among children <5years. We assessed immunogenic non-inferiority of a tetravalent bovine-human reassortant rotavirus vaccine (BRV-TV) over the licensed human-bovine pentavalent rotavirus vaccine RV5. METHODS: Phase III single-blind study (parents blinded) in healthy infants randomized (1:1) to receive three doses of BRV-TV or RV5 at 6-8, 10-12, and 14-16weeks of age. All concomitantly received a licensed diphtheria, tetanus, pertussis, hepatitis B, Haemophilus influenzae type b conjugate vaccine (DTwP-HepB-Hib) and oral polio vaccine (OPV)...
May 20, 2017: Vaccine
https://www.readbyqxmd.com/read/28527973/molecular-analysis-of-group-a-rotaviruses-detected-in-hospitalized-children-from-rawalpindi-pakistan-during-2014
#18
Massab Umair, Bilal Haider Abbasi, Nadia Nisar, Muhammad Masroor Alam, Salmaan Sharif, Shahzad Shaukat, Muhammad Suleman Rana, Adnan Khurshid, Ghulam Mujtaba, Uzma Bashir Aamir, Syed Sohail Zahoor Zaidi
As a part of strategy to control diarrheal diseases, World Health Organization (WHO) recommends to include rotavirus vaccines in national immunization programs. Sentinel surveillance networks have been established to monitor rotavirus disease burden and genotype distribution in both pre and post vaccine era in many countries. Unfortunately, due to lack of proper surveillance programs, data on rotavirus disease burden and genotype distribution from Pakistan is scarce. We investigated 502 stool samples from children (<5years) hospitalized due to gastroenteritis in Rawalpindi, Pakistan during 2014 for the presence of group A rotavirus (RVA) and its genotypic diversity...
May 17, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28523920/expression-of-bovine-rotavirus-vp8-and-preparation-of-igy-antibodies-against-recombinant-vp8
#19
H S Kim, B Lee, S Y Han, Y T Jung
Group A rotavirus is the leading cause of acute gastroenteritis in cattle and swine. Although, vaccination against this virus is an effective strategy for prevention, additional strategy to control disease is necessary. Egg yolk immunoglobulin (IgY)-based passive immunization could be a better option in preventing this disease. Bovine rotavirus (BRV) is group A rotavirus and possesses a genome of 11 segments of double-stranded RNA. The outer layer of capsid is composed of two proteins (VP7 and VP4), which induce virus neutralizing antibodies...
2017: Acta Virologica
https://www.readbyqxmd.com/read/28510686/freeze-dried-rotavirus-vaccine-shows-promise
#20
M J Friedrich
No abstract text is available yet for this article.
May 16, 2017: JAMA: the Journal of the American Medical Association
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