keyword
MENU ▼
Read by QxMD icon Read
search

Rotavirus vaccine

keyword
https://www.readbyqxmd.com/read/29149283/multivalent-rotavirus-vaccine-and-wild-type-rotavirus-strain-shedding-in-australian-infants-a-birth-cohort-study
#1
Suifang Ye, David M Whiley, Robert S Ware, Carl D Kirkwood, Stephen B Lambert, Keith Grimwood
Background: Rotavirus vaccines have reduced moderate-to-severe gastroenteritis episodes in infants and young children. Nevertheless, knowledge gaps exist concerning rotavirus vaccine shedding and vaccine impact upon mild and asymptomatic wild-type infections. Our primary objective was to investigate vaccine shedding in Australian infants where the multivalent human-bovine reassortant rotavirus vaccine, RotaTeq®, was part of the routine vaccination schedule. Methods: The Observational Research in Childhood Infectious Diseases (ORChID) birth cohort study was conducted in Brisbane, Australia, from September 2010 to October 2014...
November 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29146380/inclusion-of-the-value-of-herd-immunity-in-economic-evaluations-of-vaccines-a-systematic-review-of-methods-used
#2
REVIEW
Liv S Nymark, Tarang Sharma, Alexander Miller, Ulrika Enemark, Ulla Kou Griffiths
OBJECTIVE: The objectives of this review were to identify vaccine economic evaluations that include herd immunity and describe the methodological approaches used. METHODS: We used Kim and Goldie's search strategy from a systematic review (1976-2007) of modelling approaches used in vaccine economic evaluations and additionally searched PubMed/MEDLINE and Embase for 2007-2015. Studies were classified according to modelling approach used. Methods for estimating herd immunity effects were described, in particular for the static models...
November 13, 2017: Vaccine
https://www.readbyqxmd.com/read/29142132/identification-of-a-small-molecule-that-compromises-the-structural-integrity-of-viroplasms-and-rotavirus-double-layered-particles
#3
Catherine Eichwald, Giuditta De Lorenzo, Elisabeth M Schraner, Guido Papa, Michela Bollati, Paolo Swuec, Matteo de Rosa, Mario Milani, Eloise Mastrangelo, Mathias Ackermann, Oscar R Burrone, Francesca Arnoldi
Despite the availability of two attenuated vaccines, rotavirus (RV) gastroenteritis remains an important cause of mortality among children in developing countries causing about 215,000 infant deaths annually. Currently, there are no specific antiviral therapies available. RV is a non-enveloped virus with a segmented double-stranded RNA genome. Viral genome replication and assembly of transcriptionally active double-layered particles (DLPs) take place in cytoplasmic viral structures called viroplasms. In this study, we describe strong impairment of the early stages of RV replication induced by a small molecule known as RNA polymerase III inhibitor, ML-60218 (ML)...
November 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29142125/emergence-of-double-and-triple-gene-reassortant-g1p-8-rotaviruses-possessing-a-ds-1-like-backbone-post-rotavirus-vaccine-introduction-in-malawi
#4
Khuzwayo C Jere, Chrispin Chaguza, Naor Bar-Zeev, Jenna Lowe, Chikondi Peno, Benjamin Kumwenda, Osamu Nakagomi, Jacqueline E Tate, Umesh D Parashar, Robert S Heyderman, Neil French, Nigel A Cunliffe, Iturriza-Gomara Miren
To combat the high burden of rotavirus gastroenteritis, multiple African countries have introduced rotavirus vaccines into their childhood immunisation programmes. Malawi incorporated a G1P[8] rotavirus vaccine (Rotarix™) into its immunisation schedule in 2012. Utilising a surveillance platform of hospitalised rotavirus gastroenteritis cases, we examined the phylodynamics of G1P[8] rotavirus strains that circulated in Malawi before (1998 - 2012) and after (2013 - 2014) vaccine introduction. Analysis of whole genomes obtained through next generation sequencing revealed that all randomly-selected pre-vaccine G1P[8] strains sequenced (n=32) possessed a Wa-like genetic constellation, whereas post-vaccine G1P[8] strains (n=18) had a DS-1-like constellation...
November 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29141756/incidence-of-acute-diarrhea-associated-death-among-children-5-years-of-age-in-bangladesh-2010-12
#5
Makhdum Ahmed, Jaynal Abedin, Kazi Faisal Alam, Abdullah Al Mamun, Repon C Paul, Mahmudur Rahman, A Danielle Iuliano, Katharine Sturm-Ramirez, Umesh Parashar, Stephen P Luby, Emily S Gurley
Although acute diarrheal deaths have declined globally among children < 5 years, it may still contribute to childhood mortality as an underlying or contributing cause. The aim of this project was to estimate the incidence of acute diarrhea-associated deaths, regardless of primary cause, among children < 5 years in Bangladesh during 2010-12. We conducted a survey in 20 unions (administrative units) within the catchment areas of 10 tertiary hospitals in Bangladesh. Through social networks, our field team identified households where children < 5 years were reported to have died during 2010-12...
November 6, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29135827/norovirus-and-rotavirus-disease-severity-in-children-systematic-review-and-meta-analysis
#6
Margarita Riera-Montes, Miguel O'Ryan, Thomas Verstraeten
BACKGROUND: Rotaviruses (RV) and Noroviruses (NoV) are the most common causes of severe acute gastroenteritis (AGE) in children. It is generally accepted that RV causes severe AGE in a higher proportion of cases compared with NoV. To our knowledge, there are no systematic reviews and meta-analyses comparing the severity of NoV and RV disease. METHODS: We searched MEDLINE for studies reporting data for NoV and RV medically-attended disease severity in children. We included studies where all children had been tested for both NoV (RT-PCR) and RV (ELISA or RT-PCR) and that reported disease severity using the Vesikari or modified Vesikari score, or provided clinical information on severity...
November 11, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29135339/improving-rotavirus-vaccine-coverage-can-newer-generation-and-locally-produced-vaccines-help
#7
Jacqueline Deen, Anna Lena Lopez, Suman Kanungo, Xuan-Yi Wang, Dang Duc Anh, Milagritos Tapia, Rebecca F Grais
There are two internationally available WHO-prequalified oral rotavirus vaccines (Rotarix and RotaTeq), two rotavirus vaccines licensed in India (Rotavac and Rotasiil), one in China (Lanzhou lamb rotavirus vaccine) and one in Vietnam (Rotavin-M1), and several candidates in development. Rotavirus vaccination has been rolled out in Latin American countries and is beginning to be deployed in sub-Saharan African countries but middle- and low-income Asian countries have lagged behind in rotavirus vaccine introduction...
November 14, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29128381/early-impact-of-rotavirus-vaccination-in-children-less-than-five-years-of-age-in-mozambique
#8
Nilsa de Deus, Jorfélia José Chilaúle, Marta Cassocera, Miguel Bambo, Jerónimo Sozinho Langa, Ezequias Sitoe, Assucênio Chissaque, Elda Anapakala, Júlia Sambo, Esperança Lourenço Guimarães, Diocreciano Matias Bero, Eva Dora João, Idalécia Cossa-Moiane, Jason M Mwenda, Goitom G Weldegebriel, Umesh D Parashar, Jacqueline E Tate
BACKGROUND: Mozambique introduced rotavirus vaccine (Rotarix, GSK Biologicals) in the National Immunization Program in September 2015 with the objective of reducing the burden of total diarrheal disease and specifically severe rotavirus disease. This study aimed to evaluate the early impact of rotavirus vaccine in reducing all-cause diarrhea and rotavirus-specific hospitalizations. METHODS: We analysed stool specimens collected from children under five years old, between January 2014 and June 2017 within the National Surveillance for Acute Diarrhea...
November 8, 2017: Vaccine
https://www.readbyqxmd.com/read/29119972/rotavirus-infection
#9
REVIEW
Sue E Crawford, Sasirekha Ramani, Jacqueline E Tate, Umesh D Parashar, Lennart Svensson, Marie Hagbom, Manuel A Franco, Harry B Greenberg, Miguel O'Ryan, Gagandeep Kang, Ulrich Desselberger, Mary K Estes
Rotavirus infections are a leading cause of severe, dehydrating gastroenteritis in children <5 years of age. Despite the global introduction of vaccinations for rotavirus over a decade ago, rotavirus infections still result in >200,000 deaths annually, mostly in low-income countries. Rotavirus primarily infects enterocytes and induces diarrhoea through the destruction of absorptive enterocytes (leading to malabsorption), intestinal secretion stimulated by rotavirus non-structural protein 4 and activation of the enteric nervous system...
November 9, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29110933/temporal-association-of-rotavirus-vaccination-and-genotype-circulation-in-south-africa-observations-from-2002-to-2014
#10
N A Page, L M Seheri, M J Groome, J Moyes, S Walaza, J Mphahlele, K Kahn, C N Kapongo, H J Zar, S Tempia, C Cohen, S A Madhi
BACKGROUND: Rotavirus vaccination has reduced diarrhoeal morbidity and mortality globally. The monovalent rotavirus vaccine was introduced into the public immunization program in South Africa (SA) in 2009 and led to approximately 50% reduction in rotavirus hospitalization in young children. The aim of this study was to investigate the rotavirus genotype distribution in SA before and after vaccine introduction. MATERIALS AND METHODS: In addition to pre-vaccine era surveillance conducted from 2002 to 2008 at Dr George Mukhari Hospital (DGM), rotavirus surveillance among children <5 years hospitalized for acute diarrhoea was established at seven sentinel sites in SA from April 2009 to December 2014...
October 27, 2017: Vaccine
https://www.readbyqxmd.com/read/29110528/parental-conceptions-of-the-rotavirus-vaccine-during-implementation-in-stockholm-a-phenomenographic-study
#11
Eva Sjögren, Lina Schollin Ask, Åke Örtqvist, Margareta Asp
In 2014, Stockholm became the first Swedish county to introduce the rotavirus vaccine, which is given from as early as six weeks of age. The aim of this study was to describe parental conceptions of rotavirus infection and vaccination during its implementation as part of the child immunization program, as their support is vital for any new vaccine. The study followed a descriptive, qualitative design with a phenomenographic approach. Ten in-depth interviews with parents were conducted in Stockholm County, transcribed and analyzed to describe qualitatively different conceptions of rotavirus infection and vaccination...
January 1, 2017: Journal of Child Health Care: for Professionals Working with Children in the Hospital and Community
https://www.readbyqxmd.com/read/29107346/potential-impact-and-cost-effectiveness-of-rotavirus-vaccination-in-afghanistan
#12
Palwasha Anwari, Frederic Debellut, Clint Pecenka, Sardar M Parwiz, Andrew Clark, Devin Groman, Najibullah Safi
INTRODUCTION: Despite progress made in child survival in the past 20 years, 5.9 million children under five years died in 2015, with 9% of these deaths due to diarrhea. Rotavirus is responsible for more than a third of diarrhea deaths. In 2013, rotavirus was estimated to cause 215,000 deaths among children under five years, including 89,000 in Asia. As of April 2017, 92 countries worldwide have introduced rotavirus vaccination in their national immunization program. Afghanistan has applied for Gavi support to introduce rotavirus vaccination nationally...
October 26, 2017: Vaccine
https://www.readbyqxmd.com/read/29106113/progress-with-the-implementation-of-rotavirus-surveillance-and-vaccines-in-countries-of-the-who-african-region-2007%C3%A2-2016
#13
(no author information available yet)
No abstract text is available yet for this article.
November 3, 2017: Relevé épidémiologique Hebdomadaire
https://www.readbyqxmd.com/read/29102516/colocalization-of-intracellular-specific-iga-iciga-with-influenza-virus-in-patients-nasopharyngeal-aspirate-cells
#14
Tuck-Weng Kok, Maurizio Costabile, Gregory A Tannock, Peng Li
Inhibition of viral replication by icIgA antibodies has only been observed with in vitro studies using epithelial cell lines in transwell cultures. This effect appears to involve an interaction between polymeric immunoglobulin A (pIgA) and viral particles within an intracellular compartment, since IgA is transported across polarized cells. Polyclonal guinea pig antisera against purified influenza A virus and mouse antisera prepared against Influenza A/H3N2 hemagglutinin (HA0) cleavage loop peptides, were used in confocal fluorescence microscopy to show specific staining of wild-type influenza H1N1 and H3N2 viruses in clinical specimens...
November 2, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/29102168/impact-of-rotavirus-vaccine-on-rotavirus-diarrhoea-in-countries-of-east-and-southern-africa
#15
Goitom Weldegebriel, Jason M Mwenda, Jethro Chakauya, Fussum Daniel, Balcha Masresha, Umesh D Parashar, Jacqueline E Tate
BACKGROUND: Established in 2006 with four countries conducting hospital-based rotavirus surveillance, the African rotavirus surveillance network has expanded over subsequent years. By 2015, 14 countries in the World Health Organization (WHO) East and Southern Africa sub-region (Eritrea, Ethiopia, Kenya, Lesotho, Madagascar, Mauritius, Namibia, Rwanda, Seychelles, Swaziland, Tanzania, Uganda, Zambia and Zimbabwe) were participating in the rotavirus surveillance network coordinated by WHO...
October 25, 2017: Vaccine
https://www.readbyqxmd.com/read/29099848/health-impact-and-cost-effectiveness-of-a-domestically-produced-rotavirus-vaccine-in-india-a-model-based-analysis
#16
Johnie Rose, Laura Homa, Sharon B Meropol, Sara M Debanne, Roger Bielefeld, Claudia Hoyen, Mendel E Singer
BACKGROUND: Currently, Indian officials are incorporating a domestically manufactured rotavirus vaccine (based on the 116E rotavirus strain) into the country's universal immunization program; this vaccine will cost significantly less than western rotavirus vaccines. Here, we examine the public health impact, cost, and cost-effectiveness of universal vaccination in India using the 116E vaccine. This work will allow comparison of universal 116E vaccination with other approaches to child mortality reduction, shed light on the future burden of rotavirus disease in India, and help stakeholders understand future resource needs...
2017: PloS One
https://www.readbyqxmd.com/read/29099756/italian-physicians-opinions-on-rotavirus-vaccine-implementation
#17
Valentin Mita, Michele Arigliani, Laura Zaratti, Raffaele Arigliani, Elisabetta Franco
Rotavirus (RV) infection is the main cause of severe acute gastroenteritis (GE) in the pediatric population and has a major impact in both developing and industrialized countries. The reduction of severe RVGE cases, followed by death or hospitalization, is considered the main benefit of RV vaccination, even though its implementation often faces obstacles. In Italy, the recently approved National Immunization Plan aims to overcome the differences among regions, offering a universal free RV vaccination. The aim of the study was to evaluate the opinions on benefit and acceptability of RV vaccination related to the perception of the burden of RV disease...
November 3, 2017: Pathogens
https://www.readbyqxmd.com/read/29099653/cost-effectiveness-analysis-of-introducing-universal-childhood-rotavirus-vaccination-in-bangladesh
#18
Abdur Razzaque Sarker, Marufa Sultana, Rashidul Alam Mahumud, Robert Van Der Meer, Alec Morton
Diarrhoea is one of the world's leading killers of children, and globally, rotavirus is the most common cause of severe diarrhoea among under five children. In Bangladesh, rotavirus kills nearly 6,000 under five children in each year. To reduce the burden of childhood rotavirus diseases, universal rotavirus vaccination is recommended by World Health Organization. The objective of this study is to assess the cost-effectiveness of introducing universal childhood rotavirus vaccination with the newly developed ROTAVAC vaccine in national Expanded Programme of Immunization in Bangladesh...
November 3, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29095805/implementation-of-rotavirus-surveillance-and-vaccine-introduction-world-health-organization-african-region-2007-2016
#19
Jason M Mwenda, Rachel M Burke, Keith Shaba, Richard Mihigo, Mable Carole Tevi-Benissan, Mutale Mumba, Joseph Nsiari-Muzeyi Biey, Dah Cheikh, Alain Poy MSc, Felicitas R Zawaira, Negar Aliabadi, Jacqueline E Tate, Terri Hyde, Adam L Cohen, Umesh D Parashar
Rotavirus is a leading cause of severe pediatric diarrhea globally, estimated to have caused 120,000 deaths among children aged <5 years in sub-Saharan Africa in 2013 (1). In 2009, the World Health Organization (WHO) recommended rotavirus vaccination for all infants worldwide (2). Two rotavirus vaccines are currently licensed globally: the monovalent Rotarix vaccine (RV1, GlaxoSmithKline; 2-dose series) and the pentavalent RotaTeq vaccine (RV5, Merck; 3-dose series). This report describes progress of rotavirus vaccine introduction (3), coverage (using estimates from WHO and the United Nations Children's Fund [UNICEF]) (4), and impact on pediatric diarrhea hospitalizations in the WHO African Region...
November 3, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29079394/optimising-the-introduction-of-multiple-childhood-vaccines-in-japan-a-model-proposing-the-introduction-sequence-achieving-the-highest-health-gains
#20
Baudouin Standaert, Nadia Schecroun, Olivier Ethgen, Oleksandr Topachevskyi, Yoriko Morioka, Ilse Van Vlaenderen
BACKGROUND: Many countries struggle with the prioritisation of introducing new vaccines because of budget limitations and lack of focus on public health goals. A model has been developed that defines how specific health goals can be optimised through immunisation within vaccination budget constraints. METHODS: Japan, as a country example, could introduce 4 new pediatric vaccines targeting influenza, rotavirus, pneumococcal disease and mumps with known burden of disease, vaccine efficacies and maximum achievable coverages...
September 21, 2017: Health Policy
keyword
keyword
3187
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"