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Rotavirus vaccine

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https://www.readbyqxmd.com/read/28441094/background-rates-of-disease-in-latin-american-children-from-a-rotavirus-vaccine-study
#1
Marc Baay, Kaatje Bollaerts, Claudio Struchiner, Thomas Verstraeten
BACKGROUND: Knowledge of background rates of adverse events is crucial to assess vaccine safety concerns. We used data from a rotavirus vaccine study (Ruiz-Palacios et al., NEJM, 2006) including 63,225 infants from 11 Latin American countries to investigate reporting rates of serious adverse events (SAEs) among these infants, and describe rates by country, gender, age, and season. METHODS: For this randomized, double-blind, placebo-controlled, phase 3 trial, investigators from Argentina, Brazil, Chile, Colombia, Dominican Republic, Honduras, Mexico, Nicaragua, Panama, Peru, and Venezuela recruited 6-to-13-week-old healthy infants...
April 25, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28438670/epidemiological-features-and-genetic-characterization-of-virus-strains-in-rotavirus-associated-gastroenteritis-in-children-of-odisha-in-eastern-india
#2
Eileena Mohanty, Bhagirathi Dwibedi, S K Kar, A S Acharya
We have studied the clinical characteristics, severity and seasonality of rotavirus infection and prevalent genotypes in 652 non-rota vaccinated children in Odisha in eastern India. P genotypes were analysed for their association with host blood group antigens. P type of the virus is determined by the VP8* gene, and specific recognition of A - type of Histo - blood group antigen by P[14]VP8* has been reported. VP4, VP7 and VP6 genes of commonly identified G1P[8] strain were compared with genes of the same strain isolated from other parts of India, elsewhere and strains used for Rotarix and Rotateq vaccines...
April 21, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28434688/stability-of-heat-stable-live-attenuated-rotavirus-vaccine-rotasiil%C3%A2
#3
Sameer P Naik, Jagdish K Zade, Rajendra N Sabale, Sambhaji S Pisal, Ravi Menon, Subhash G Bankar, Sunil Gairola, Rajeev M Dhere
Vaccines currently available across the globe are stored and transported in a continuous cold-chain at 2-8°C or below -20°C. A temperature excursion outside this range affects the potency of the vaccines. Such vaccines need to be discarded leading wastage. The Rotavirus disease burden is predominantly reported in developing and low-income countries and therefore, has entered or poised to enter their national immunization programs. These countries already have several limitations for effective storage, maintenance and distribution of vaccines in a cold-chain and this introduction is expected to further stress this fragile ecosystem...
April 20, 2017: Vaccine
https://www.readbyqxmd.com/read/28432676/bifidobacterium-adolescentis-dsm-20083-and-lactobacillus-casei-lafti-l26-dsl-probiotics-able-to-block-the-in-vitro-adherence-of-rotavirus-in-ma104-cells
#4
Karem Prunella Fernandez-Duarte, Nury Nathalia Olaya-Galán, Sandra Patricia Salas-Cárdenas, Jazmin Lopez-Rozo, Maria Fernanda Gutierrez-Fernandez
Rotavirus is the leading worldwide cause of gastroenteritis in children under five years of age. Even though there are some available vaccines to prevent the disease, there are limited strategies for challenging diarrhea induced by rotavirus infection. For this reason, researchers are constantly searching for other approaches to control diarrhea by means of probiotics. In order to demonstrate the ability of some probiotic bacteria to interfere with the in vitro rotavirus infection in MA104 cells, strains of Lactobacillus sp...
April 21, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/28431126/global-impact-of-rotavirus-vaccination-on-childhood-hospitalizations-and-mortality-from-diarrhea
#5
E Anthony S Nelson, A Duncan Steele
No abstract text is available yet for this article.
April 18, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28430997/global-impact-of-rotavirus-vaccination-on-childhood-hospitalizations-and-mortality-from-diarrhea
#6
Eleanor Burnett, Christine L Jonesteller, Jacqueline E Tate, Catherine Yen, Umesh D Parashar
In 2006, two rotavirus vaccines were licensed. We summarize the impact of rotavirus vaccination on hospitalizations and deaths from rotavirus and all-cause acute gastroenteritis (AGE) during the first 10 years since vaccine licensure, including recent evidence from high child mortality countries. We used standardized guidelines (PRISMA) guidelines to identify observational evaluations of rotavirus vaccine impact among children <5 years of age that presented at least 12 months of pre- and post-vaccine introduction surveillance data...
April 18, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28427846/vaccines-are-different-a-systematic-review-of-budget-impact-analyses-of-vaccines
#7
REVIEW
Priscilla Magalhaes Loze, Luciana Bertholim Nasciben, Ana Marli Christovam Sartori, Alexander Itria, Hillegonda Maria Dutilh Novaes, Patrícia Coelho de Soárez
INTRODUCTION: Several countries require manufacturers to present a budget impact analysis (BIA), together with a cost-effectiveness analysis, to support national funding requests. However, guidelines for conducting BIA of vaccines are scarce. OBJECTIVES: To analyze the methodological approaches used in published budget impact analysis (BIA) of vaccines, discussing specific methodological issues related to vaccines. MATERIAL AND METHODS: This systematic review of the literature on BIA of vaccines was carried out in accordance with the Centre for Reviews and Dissemination - CRD guidelines...
April 17, 2017: Vaccine
https://www.readbyqxmd.com/read/28425908/rotavirus-vaccine-breastfeeding-and-other-factors-that-could-affect-susceptibility-to-gastroenteritis-in-young-children
#8
Amy Elizabeth Murphy
No abstract available.
April 20, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/28422995/characterization-of-rotavirus-infection-in-children-with-acute-gastroenteritis-in-bengo-province-northwestern-angola-prior-to-vaccine-introduction
#9
Carolina Gasparinho, João Piedade, Maria Clara Mirante, Cristina Mendes, Carlos Mayer, Susana Vaz Nery, Miguel Brito, Claudia Istrate
BACKGROUND: Rotavirus group A (RVA) is considered the leading cause of pediatric diarrhea, responsible for the high burden of diarrheal diseases in sub-Saharan Africa. Despite recent studies, the existent data are scarce for some African countries like Angola, a country with one of the highest RVA-related death estimates. The aim of this study was to determine the RVA detection rate and circulating genotypes in children less than five years of age with acute gastroenteritis attended at the Bengo General Hospital in Caxito, Bengo province, Angola, before vaccine introduction...
2017: PloS One
https://www.readbyqxmd.com/read/28419538/receiving-early-information-and-trusting-swedish-child-health-centre-nurses-increased-parents-willingness-to-vaccinate-against-rotavirus-infections
#10
Lina Schollin Ask, Anders Hjern, Ann Lindstrand, Ola Olen, Eva Sjögren, Margareta Blennow, Åke Örtqvist
AIM: Rotavirus vaccines are effective against severe infections, but have a modest impact on mortality in high-income countries. Parental knowledge and attitudes towards vaccines are crucial for high vaccination coverage. This study aimed to identify why parents refused to let their infant have the vaccination or were unsure. METHODS: This cross-sectional study was based on 1,063 questionnaires completed by the parents of newborn children in 2014. Stepwise logistic regression was used to identify the main predictors...
April 17, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28419095/effectiveness-of-a-live-oral-human-rotavirus-vaccine-after-programmatic-introduction-in-bangladesh-a-cluster-randomized-trial
#11
K Zaman, David A Sack, Kathleen M Neuzil, Mohammad Yunus, Lawrence H Moulton, Jonathan D Sugimoto, Jessica A Fleming, Ilias Hossain, Shams El Arifeen, Tasnim Azim, Mustafizur Rahman, Kristen D C Lewis, Andrea J Feller, Firdausi Qadri, M Elizabeth Halloran, Alejandro Cravioto, John C Victor
BACKGROUND: Rotavirus vaccines are now globally recommended by the World Health Organization (WHO), but in early 2009 WHO's Strategic Advisory Group of Experts on Immunization reviewed available data and concluded that there was no evidence for the efficacy or effectiveness of a two-dose schedule of the human rotavirus vaccine (HRV; Rotarix) given early at 6 and 10 wk of age. Additionally, the effectiveness of programmatic rotavirus vaccination, including possible indirect effects, has not been assessed in low-resource populations in Asia...
April 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28416666/drebrin-restricts-rotavirus-entry-by-inhibiting-dynamin-mediated-endocytosis
#12
Bin Li, Siyuan Ding, Ningguo Feng, Nancie Mooney, Yaw Shin Ooi, Lili Ren, Jonathan Diep, Marcus R Kelly, Linda L Yasukawa, John T Patton, Hiroyuki Yamazaki, Tomoaki Shirao, Peter K Jackson, Harry B Greenberg
Despite the wide administration of several effective vaccines, rotavirus (RV) remains the single most important etiological agent of severe diarrhea in infants and young children worldwide, with an annual mortality of over 200,000 people. RV attachment and internalization into target cells is mediated by its outer capsid protein VP4. To better understand the molecular details of RV entry, we performed tandem affinity purification coupled with high-resolution mass spectrometry to map the host proteins that interact with VP4...
April 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28414969/cytokines-in-the-management-of-rotavirus-infection-a-systematic-review-of-in-vivo-studies
#13
REVIEW
Gopalsamy Rajiv Gandhi, Victor Santana Santos, Marina Denadai, Valdete Kaliane da Silva Calisto, Jullyana de Souza Siqueira Quintans, Ana Mara de Oliveira E Silva, Adriano Antunes de Souza Araújo, Narendra Narain, Luis Eduardo Cuevas, Lucindo José Quintans Júnior, Ricardo Queiroz Gurgel
OBJECTIVE: Rotavirus is a leading cause of childhood diarrhoea. Rotavirus vaccines are effective against severe rotavirus gastroenteritis, but have lower efficacy in low income countries in Africa. Anti-rotavirus treatment is not available. This study reviews the literature of animal studies evaluating whether cytokine mediated pathways of immune activation could improve rotavirus therapy. METHODS: We performed a systematic review of articles in English published from 2010 to 2016 reporting agents with in vivo antirotavirus activity for the management of rotavirus infection...
April 14, 2017: Cytokine
https://www.readbyqxmd.com/read/28413695/one-step-quantitative-rt-pcr-assays-for-detecting-genotyping-and-differentiating-wild-type-group-a-rotaviruses-and-vaccine-rotarix-%C3%A2-and-rotateq-%C3%A2-strains-in-stool-samples
#14
Rashi Gautam, Michael D Bowen
No abstract text is available yet for this article.
September 26, 2016: Journal of Vaccines & Vaccination
https://www.readbyqxmd.com/read/28407442/rotavirus-capsid-vp6-tubular-and-spherical-nanostructures-act-as-local-adjuvants-when-co-delivered-with-norovirus-vlps
#15
Maria Malm, Suvi Heinimäki, Timo Vesikari, Vesna Blazevic
A subunit protein vaccine candidate based on norovirus (NoV) virus-like particles (VLPs) and rotavirus (RV) VP6 protein against acute childhood gastroenteritis has been recently proposed. RV VP6 forms different oligomeric nanostructures, including tubes and spheres when expressed in vitro, which are highly immunogenic in different animal models. We have recently shown that recombinant VP6 nanotubes have an adjuvant effect on immunogenicity of NoV VLPs in mice. In this study, we investigated if the adjuvant effect is dependent on a VP6 dose or different VP6 structural assemblies...
April 13, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28403085/is-rotavirus-still-a-major-cause-for-diarrheal-illness-in-hospitalized-pediatric-patients-after-rotavirus-vaccine-introduction-in-the-saudi-national-immunization-program
#16
Moustafa Abdelaal Hegazi, Mohamed Hesham Sayed, Haifa Hasan Sindi, Osama Elsayed Bekhit, Basem Salama El-Deek, Faisal M Yaqoub Alshoudri, Amroo Khaled Noorelahi
Previous studies in Jeddah, western Saudi Arabia, showed rotavirus (RV) prevalence around 40% in pediatric inpatients with gastroenteritis (GE) with a maximum level during cooler months. Currently, there are no data on impact of rotavirus vaccine (RVV) on RV-GE in Saudi Arabia. Therefore, this study was conducted to assess impact of RVV on incidence and severity of RV-GE in hospitalized pediatric patients; 3 years after introduction of RVV in Saudi immunization program (SIP) in January, 2013.This cross-sectional observational study included GE cases under 5 years of age admitted to 2 tertiary hospitals, in Jeddah, from October to December, 2015...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28401056/effect-of-metronidazole-in-infants-with-bowel-habit-change-irrelative-to-the-clostridium-difficile-colonization
#17
Eun Jin Kim, Sung Hyun Lee, Hann Tchah, Eell Ryoo
PURPOSE: Clinical symptoms associated with Clostridium difficile infection (CDI) can vary widely. Carrier state without apparent symptoms is relatively common during infancy. The objective of this study was to determine the association of C. difficile colonization with bowel habit change and the effect of C. difficile colonization treatment on restoration of normal bowel habit. METHODS: Between 2006 and 2014, infants at 1 to 12 months of age with diarrhea for more than 2 weeks who did not improve with conservative care were recruited from Gachon University Gil Medical Center...
March 2017: Pediatric Gastroenterology, Hepatology & Nutrition
https://www.readbyqxmd.com/read/28400626/diarrhoea-low-cost-rotavirus-vaccine-shows-efficacy-in-niger
#18
Iain Dickson
No abstract text is available yet for this article.
April 12, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28400594/histo-blood-group-antigens-as-receptors-for-rotavirus-new-understanding-on-rotavirus-epidemiology-and-vaccine-strategy
#19
REVIEW
Xi Jiang, Yang Liu, Ming Tan
The success of the two rotavirus (RV) vaccines (Rotarix and RotaTeq) in many countries endorses a live attenuated vaccine approach against RVs. However, the lower efficacies of both vaccines in many low- and middle-income countries indicate a need to improve the current RV vaccines. The recent discovery that RVs recognize histo-blood group antigens (HBGAs) as potential receptors has significantly advanced our understanding of RV diversity, evolution and epidemiology, providing important new insights into the performances of current RV vaccines in different populations and emphasizing a P-type-based vaccine approach...
April 12, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28399824/long-term-impact-of-self-financed-rotavirus-vaccines-on-rotavirus-associated-hospitalizations-and-costs-in-the-valencia-region-spain
#20
Alejandro Orrico-Sanchez, Mónica López-Lacort, Silvia Pérez-Vilar, Javier Díez-Domingo
BACKGROUND: Rotavirus vaccines are available in Spain from 2007. They are recommended by the Spanish Pediatric Association, but not funded by the National Health System (NHS) and its coverage rate reached 40-50%. The hospitalization rate reduction of rotavirus caused gastroenteritis (RVAGE) directly attributable to vaccination remains unclear due to the large differences described in published studies, ranging from 14 to 44.5% in children <5 years of age, even with similar vaccination coverage...
April 11, 2017: BMC Infectious Diseases
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