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https://www.readbyqxmd.com/read/29785948/-genetics-of-fertility-restoration-in-the-isocytoplasm-allonuclear-c-group-of-cytoplasmic-male-sterility-in-maize
#1
Zhuo Fan Zhao, Ling Huang, Yong Ming Liu, Peng Zhang, Gui Wei, Mo Ju Cao
Maize is one of the first crops to produce hybrids using cytoplasmic male sterile lines. The C-type cytoplasmic male sterile (CMS-C) line is vital for hybrid seed production, and the fertility-restoration reaction along with its stability has a direct bearing on its applications. However, fertility restoration mechanism of CMS-C is complex and is still not clear so far. To further explore the factors affecting the fertility restoration of maize CMS, a series of test crosses were carried out by pollinating the isocytoplasm allonuclear CMS-C lines C48-2, Chuangzaosi and C478 with the test lines 18 bai, zi 330, 5022 and the restorer line A619, respectively...
May 20, 2018: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/29777604/-ethical-aspects-of-the-use-of-mirena-r-iud-in-the-treatment-of-heavy-menstrual-bleeding
#2
Miriam Turiel Miranda, Pau Agulles Simó
The levonorgestrel-releasing intrauterine device known as Mirena IUD(r) (20mcg/24h) is nowadays considered among the leading resources in the treatment of heavy menstrual bleeding. Nonetheless, due to either its effect of prevention of conception and especially to the possibility that it may also have an anti-implantation effect, there is a founded concern on whether its therapeutic use may be ethically licit. This article engages in an exhaustive literature review in order to ascertain the mechanism of action of Mirena(r) IUD, in view of an ethical evaluation of its therapeutic use, keeping in mind those two unwanted effects...
May 2018: Cuadernos de Bioética: Revista Oficial de la Asociación Española de Bioética y Ética Médica
https://www.readbyqxmd.com/read/29775821/vermiremediation-of-metal-loid-s-via-eichornia-crassipes-phytomass-extraction-a-sustainable-technique-for-plant-amelioration
#3
Arnab Majumdar, Anil Barla, Munish Kumar Upadhyay, Dibyarpita Ghosh, Punarbasu Chaudhuri, Sudhakar Srivastava, Sutapa Bose
Eichhornia crassipes (water hyacinth), imparts deficiency of soluble arsenic and other toxic metal (loid)s through rhizofiltration and phytoaccumulation. Without proper management strategy, this phytoremediation of metal (loid)s might fail and get reverted back to the environment, contaminating the nearby water bodies. This study, focused on bio-conversion of phytoremediating hyacinths, spiked with 100 times and greater arsenic, lead and cadmium concentrations than the average water contamination, ranging in 58...
May 15, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29774260/can-the-uk-s-birth-registration-system-better-serve-the-interests-of-those-born-following-collaborative-assisted-reproduction
#4
Marilyn A Crawshaw, Eric D Blyth, Julia Feast
Current birth registration systems fail to serve adequately the interests of those born as a result of gamete and embryo donation and surrogacy. In the UK, changes to the birth registration system have been piecemeal, reactive and situation-specific and no information is recorded about gamete donors. Birth registration has thereby become a statement of legal parentage and citizenship only, without debate as to whether it should serve any wider functions. This sits uneasily with the increasingly accepted human right to know one's genetic and gestational as well as legal parents, and the duty of the State to facilitate that right...
June 2017: Reproductive Biomedicine & Society Online
https://www.readbyqxmd.com/read/29760715/higher-temperature-at-lower-elevation-sites-fails-to-promote-acclimation-or-adaptation-to-heat-stress-during-pollen-germination
#5
Lluvia Flores-Rentería, Amy V Whipple, Gilbert J Benally, Adair Patterson, Brandon Canyon, Catherine A Gehring
High temperatures associated with climate change are expected to be detrimental for aspects of plant reproduction, such as pollen viability. We hypothesized that (1) higher peak temperatures predicted with climate change would have a minimal effect on pollen viability, while high temperatures during pollen germination would negatively affect pollen viability, (2) high temperatures during pollen dispersal would facilitate acclimation to high temperatures during pollen germination, and (3) pollen from populations at sites with warmer average temperatures would be better adapted to high temperature peaks...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29757396/hetero-fertilization-along-with-failed-egg-sperm-cell-fusion-supports-single-fertilization-involved-in-in-vivo-haploid-induction-in-maize
#6
Xiaolong Tian, Yuanxin Qin, Baojian Chen, Chenxu Liu, Lele Wang, Xingli Li, Xin Dong, Liwei Liu, Shaojiang Chen
In vivo doubled-haploid technology is widely applied in commercial maize breeding programs owing to its time-saving and cost-reducing features. The production of maize haploids primarily depends on the use of the Stock6-derived haploid inducer lines. Although the gene underlying haploid induction, MTL/ZmPLA1/NLD, was cloned recently, the mechanism of haploid induction is still unknown. Hetero-fertilization can occur via a single fertilization, which pave a way to investigate single-fertilization events by studying the hetero-fertilization phenomenon...
May 11, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29753018/ets-transcription-factor-etsrp-etv2-is-required-for-lymphangiogenesis-and-directly-regulates-vegfr3-flt4-expression
#7
Jennifer A Davis, Andrew L Koenig, Allison Lubert, Brendan Chestnut, Fang Liu, Sharina Palencia Desai, Tamara Winkler, Karolina Pociute, Kyunghee Choi, Saulius Sumanas
The molecular mechanisms initiating the formation of the lymphatic system, lymphangiogenesis, are still poorly understood. Here we have identified a novel role in lymphangiogenesis for an ETS transcription factor, Etv2/Etsrp, a known regulator of embryonic vascular development. Through the use of fully validated photoactivatable morpholinos we show that inducible Etv2 inhibition in zebrafish embryos at 1day post-fertilization (dpf) results in significant inhibition of lymphangiogenesis, while development of blood vessels is unaffected...
May 9, 2018: Developmental Biology
https://www.readbyqxmd.com/read/29752986/perinatal-bpa-exposure-and-reproductive-axis-function-in-cd-1-mice
#8
Nicole Acevedo, Beverly S Rubin, Cheryl M Schaeberle, Ana M Soto
Perinatal Bisphenol-A (BPA) exposure reduces fertility and fecundity in mice. This study examined effects of early BPA exposure on activation of gonadotropin releasing hormone (GnRH) neurons in conjunction with a steroid-induced luteinizing hormone (LH) surge, characterized patterns of estrous cyclicity and fertility over time, and assessed the ovarian follicular reserve to further explore factors responsible for the reduced fertility we previously described in this model. The percent activated GnRH neurons was reduced in BPA exposed females at 3-6 months, and periods of persistent proestrus was increased...
May 9, 2018: Reproductive Toxicology
https://www.readbyqxmd.com/read/29746897/the-role-of-ca-2-in-oocyte-activation-during-in-vitro-fertilization-insights-into-potential-therapies-for-rescuing-failed-fertilization
#9
REVIEW
Karl Swann
At fertilization the mature mammalian oocyte is activated to begin development by a sperm-induced series of increases in the cytosolic free Ca2+ concentration. These so called Ca2+ oscillations, or repetitive Ca2+ , are also seen after intracytoplasmic sperm injection (ICSI) and are primarily triggered by a sperm protein called phospholipase Czeta (PLCζ). Whilst ICSI is generally an effective way to fertilizing human oocytes, there are cases where oocyte activation fails to occur after sperm injection. Many such cases appear to be associated with a PLCζ deficiency...
May 7, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29733416/administration-of-recombinant-bovine-somatotropin-prior-to-fixed-time-artificial-insemination-and-the-effects-on-fertility-embryo-and-fetal-size-in-beef-heifers
#10
Nicola Oosthuizen, Pedro L P Fontes, Darren D Henry, Francine M Ciriaco, Carla D Sanford, Luara B Canal, Gentil V de Moraes, Nicolas DiLorenzo, John F Currin, Sherrie Clark, William D Whittier, Vitor R G Mercadante, G Cliff Lamb
Our objectives were to determine the effects of the administration of recombinant bovine somatotropin (bST) at the initiation of a fixed-time AI (TAI) protocol on concentrations of plasma IGF-1, follicle diameter, embryo/fetal size, and pregnancy rates in replacement beef heifers. Four hundred and fourteen Angus-based beef heifers were enrolled in a completely randomized design at 4 locations from January to July of 2016. All heifers were exposed to the 7-d CO-Synch + controlled internal drug release (CIDR) protocol where they received a 100-µg injection of GnRH and a CIDR insert on day -9, 25 mg of PGF2α at CIDR removal on day -2, followed by a 100-µg injection of GnRH and TAI 54 ± 2 h later on day 0...
May 4, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29727537/-testicular-histology-does-not-affect-the-clinical-outcomes-of-icsi-in-men-with-non-obstructive-azoospermia
#11
Yan-Rong Kuai, Zhan-Ju He, Sheng Wang, Kai Zhang, Cheng Zeng, Liang Chen, Qing Xue, Jing Shang, Hui-Xia Yang, Yang Xu
Objective: To investigate whether testicular histology influences the clinical outcomes of intracytoplasmic sperm injection (ICSI) in men with non-obstructive azoospermia (NOA). METHODS: We retrospectively analyzed the clinical data about 73 cases of NOA undergoing ICSI, including 105 ICSI cycles and 79 embryo transfer cycles. The infertility of the patients was attributed to male factors only or both male and female tube factors and the females' age was ≤38 years...
October 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
https://www.readbyqxmd.com/read/29700821/efficacy-of-low-molecular-weight-heparin-on-the-outcomes-of-ivf-icsi-pregnancy-in-non-thrombophilic-women-a-meta-analysis
#12
Xiu-Li Yang, Fei Chen, Xiu-Ying Yang, Guan-Hua Du, Yang Xu
INTRODUCTION: The aim of our study was to evaluate the effect of low-molecular-weight heparin (LMWH) on pregnancy outcomes in women without thrombophilia during in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) treatment. MATERIAL AND METHODS: We searched Pubmed, Web of Science, Embase, Cochrane and CNKI (from inception to 2 February 2018). Our study identified randomized controlled trials or quasi- randomized controlled trials comparing LMWH subcutaneous treatment with no treatment or only luteal support control...
April 27, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29697805/single-cell-analysis-of-ca2-i-signalling-in-sub-fertile-men-characteristics-and-relation-to-fertilization-outcome
#13
Mark C Kelly, Sean G Brown, Sarah M Costello, Mythili Ramalingam, Ellen Drew, Stephen J Publicover, Christopher L R Barratt, Sarah Martins Da Silva
STUDY QUESTION: What are the characteristics of progesterone-induced (CatSper-mediated) single cell [Ca2+]i signals in spermatozoa from sub-fertile men and how do they relate to fertilizing ability? SUMMARY ANSWER: Single cell analysis of progesterone-induced (CatSper-mediated) [Ca2+]i showed that reduced progesterone-sensitivity is a common feature of sperm from sub-fertile patients and is correlated with fertilization rate. WHAT IS KNOWN ALREADY: Stimulation with progesterone is a widely used method for assessing [Ca2+]i mobilization by activation of CatSper in human spermatozoa...
April 25, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29694638/a-review-of-cushing-s-disease-treatment-by-the-department-of-neuroendocrinology-of-the-brazilian-society-of-endocrinology-and-metabolism
#14
Márcio Carlos Machado, Maria Candida Barisson Vilares Fragoso, Ayrton Custódio Moreira, César Luiz Boguszewski, Leonardo Vieira Neto, Luciana A Naves, Lucio Vilar, Luiz Antônio de Araújo, Nina Rosa Castro Musolino, Paulo Augusto C Miranda, Mauro A Czepielewski, Monica R Gadelha, Marcello Delano Bronstein, Antônio Ribeiro-Oliveira
The treatment objectives for a patient with Cushing's disease (CD) are remission of hypercortisolism, adequate management of co-morbidities, restoration of the hypothalamic-pituitary-adrenal axis, preservation of fertility and pituitary function, and improvement of visual defects in cases of macroadenomas with suprasellar extension. Transsphenoidal pituitary surgery is the main treatment option for the majority of cases, even in macroadenomas with low probability of remission. In cases of surgical failure, another subsequent pituitary surgery might be indicated in cases with persistent tumor imaging at post surgical magnetic resonance imaging (MRI) and/or pathology analysis of adrenocorticotropic hormone-positive (ACTH+) positive pituitary adenoma in the first procedure...
February 2018: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29693775/the-c-elegans-spe-49-gene-is-required-for-fertilization-and-encodes-a-sperm-specific-transmembrane-protein-homologous-to-spe-42
#15
Luke D Wilson, Omoyemwen A Obakpolor, Autumn M Jones, Abigail L Richie, Bryce D Mieczkowski, Gabriel T Fall, Rosine W Hall, Jon N Rumbley, Tim L Kroft
Fertilization, the fusion of sperm and oocyte to form a zygote, is the first and arguably the most important cell-cell interaction event in an organism's life. Forward and reverse genetic approaches in the nematode Caenorhabditis elegans have identified many genes that are required for gametogenesis and fertilization, and thus are beginning to elucidate the molecular pathways that underlie these processes. We identified an allele of the spe-49 gene in an F2 mutagenesis screen for spermatogenesis defective (spe) mutants...
April 25, 2018: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/29681715/can-intracytoplasmic-morphologically-selected-spermatozoa-injection-be-used-as-first-choice-of-treatment-for-severe-male-factor-infertility-patients
#16
Geeta Goswami, Meeta Sharma, Deepika Jugga, Devi M Gouri
Aim: This study was carried out to assess the outcome of the intracytoplasmic morphologically selected sperm injection (IMSI) technique compared with the previous failed intracytoplasmic sperm injection (ICSI) attempts in oligoasthenoteratozoospermia (OAT)/severe OAT (SOAT)/teratozoospermia patients. Setting: Institution-based, in vitro fertilization center. Study Design: It was a nonrandomized prospective study including 57 couples who had previous one or two ICSI failures (failure due to no implantation as embryos were transferred in these cycles and had no pregnancy) due to male factor...
January 2018: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29680904/abnormal-development-of-floral-meristem-triggers-defective-morphogenesis-of-generative-system-in-transgenic-tomatoes
#17
Inna Chaban, Marat Khaliluev, Ekaterina Baranova, Neonila Kononenko, Sergey Dolgov, Elena Smirnova
Parthenocarpy and fruit malformations are common among independent transgenic tomato lines, expressing genes encoding different pathogenesis-related (PR) protein and antimicrobal peptides. Abnormal phenotype developed independently of the expression and type of target genes, but distinctive features during flower and fruit development were detected in each transgenic line. We analyzed the morphology, anatomy, and cytoembryology of abnormal flowers and fruits from these transgenic tomato lines and compared them with flowers and fruits of wild tomatoes, line YaLF used for transformation, and transgenic plants with normal phenotype...
April 21, 2018: Protoplasma
https://www.readbyqxmd.com/read/29680465/treatment-strategies-and-cumulative-live-birth-rates-in-who-ii-ovulation-disorders
#18
Sanne C Braam, Jan Peter de Bruin, Erato T I A Buisman, Monique Brandes, Willianne L D M Nelen, Jesper M J Smeenk, Jan Willem van der Steeg, Ben Willem J Mol, Carl J C M Hamilton
OBJECTIVE: To assess the live birth rate in women with WHO II anovulation and the proportion of women that need second or third line treatments if the initial therapy fails. STUDY DESIGN: In this multicenter cohort study we included couples with unfulfilled child wish who were referred to three fertility clinics in the Netherlands and selected women with a WHO II ovulation disorder as the only final infertility diagnosis (n = 468). RESULTS: The cumulative live birth rate of the total group was 82% (383/468)...
April 10, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29673680/two-cesarean-deliveries-after-hemi-hysterectomy-due-to-gestational-trophoblastic-neoplasia
#19
Kentaro Kai, Yasushi Kawano, Mitsutake Yano, Mamiko Okamoto, Eiichi Hori, Kaei Nasu, Hisashi Narahara
OBJECTIVE: Although uterine didelphys per se is not associated with an impaired ability to conceive, the association between uterine anomalies and gestational trophoblastic neoplasia (GTN) remains unclear. The management of chemotherapy-resistant GTN in women with uterine didelphys raises a new issue regarding whether to perform a hemi-hysterectomy. CASE REPORT: A 23-year-old, gravida 1, para 0 Japanese woman was referred with a failed intermittent cervical dilatation for hematometra...
April 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29651940/proteomics-in-human-assisted-reproduction
#20
Mauro Bibancos De Rose, Mariana Moraes Piccolomini
Assisted reproduction techniques (ART) have significantly advanced since the first successful in vitro fertilization (IVF). However, most in vitro-produced embryos fail to implant. Key steps in ART are the correct infertility diagnosis, in order to manage the individual treatments, and the assessment of gamete and embryo viability, to identify the embryo with the best implantation potential. Non-invasive approaches to correctly diagnose infertility and to access embryo development potential have the advantages of increasing the knowledge of embryo physiology, therefore allowing the development of methods to predict developmental competence and viability...
April 12, 2018: Protein and Peptide Letters
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