Jone Marita Kvam, Maja Lind Nybo, Lola Torz, Riia Karolina Sustarsic, Kristian Høj Reveles Jensen, John Erik Nielsen, Hanne Frederiksen, Sarina Gadgaard, Katja Spiess, Steen Seier Poulsen, Jesper Skovhus Thomsen, Pamela Cowin, Martin Blomberg Jensen, Takeshi Kurita, Mette Marie Rosenkilde
BACKGROUND: Ten percent of the female population suffers from congenital abnormalities of the vagina, uterus, or oviducts, with severe consequences for reproductive and psychological health. Yet, the underlying causes of most of these malformations remain largely unknown. ADGRA3 (GPR125) is involved in WNT signaling and planar cell polarity, mechanisms vital to female reproductive tract development. Although ADGRA3 is a well-established spermatogonial stem cell marker, its role within the female urogenital system remains unclear...
April 8, 2024: BMC Biology