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https://www.readbyqxmd.com/read/28306344/live-birth-after-replacement-of-an-embryo-obtained-from-a-spontaneously-in-vitro-matured-metaphase-i-oocyte
#1
Paloma Piqueras, Miguel Gallardo, María Hebles, Juan Manuel Jiménez, Beatriz Migueles, Lorena Montero, Fernando Sánchez-Martín, Pascual Sánchez-Martín
This case report describes a live birth after the fresh replacement of an embryo obtained from a spontaneously in vitro matured oocyte. The patient was subjected to controlled ovarian stimulation for IVF treatment, obtaining two oocytes. One was found to be immature at the time of denudation, at metaphase-I. This immature oocyte was kept in culture overnight in standard conditions along with the second oocyte - which was mature but failed to fertilize - spontaneously achieving metaphase-II, and was subjected to ICSI...
March 17, 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/28291830/soluble-cd146-an-innovative-and-non-invasive-biomarker-of-embryo-selection-for-in-vitro-fertilization
#2
Sylvie Bouvier, Odile Paulmyer-Lacroix, Nicolas Molinari, Alexandrine Bertaud, Marine Paci, Aurélie Leroyer, Stéphane Robert, Françoise Dignat George, Marcel Blot-Chabaud, Nathalie Bardin
Although progress was made in in vitro fertilization (IVF) techniques, the majority of embryos transferred fail to implant. Morphology embryo scoring is the standard procedure for most of IVF centres for choosing the best embryo, but remains limited since even the embryos classified as "top quality" may not implant. As it has been shown that i) CD146 is involved in embryo implantation and ii) membrane form is shed to generate soluble CD146 (sCD146), we propose that sCD146 in embryo supernatants may constitute a new biomarker of embryo selection...
2017: PloS One
https://www.readbyqxmd.com/read/28271530/-it-s-like-taking-a-bit-of-masculinity-away-from-you-towards-a-theoretical-understanding-of-men-s-experiences-of-infertility
#3
Alan Dolan, Tim Lomas, Tarek Ghobara, Geraldine Hartshorne
In the UK, nearly half of all cases of infertility involve a 'male-factor'. Yet, little empirical work has explored how men as men negotiate this terrain. Three interrelated concepts; 'hegemonic masculinity', 'embodied masculinity' and the linkages between 'masculinities' and male help-seeking, provide the theoretical framework that guided a qualitative study conducted with 22 men experiencing infertility. The paper explores men's propensity to delay their help-seeking in relation to infertility despite their desire for children...
March 8, 2017: Sociology of Health & Illness
https://www.readbyqxmd.com/read/28270719/listening-through-narratives-using-a-narrative-approach-when-discussing-fertility-preservation-options-with-young-cancer-patients
#4
S I G Roher, J Gibson, B E Gibson, A A Gupta
Despite clinical practice guideline recommendations mandating that fertility preservation be discussed with young cancer patients, many providers fail to initiate such discussions with adolescents. Researchers and clinicians often focus on system-level changes to improve access to fertility preservation for adolescents and young adults in Canada. However, little of the available information considers the way in which health care providers approach those discussions. Research has shown that, even when fertility preservation options are broached with adolescents, survivors often report dissatisfaction with those conversations, thus raising additional concerns about their content and quality...
February 2017: Current Oncology
https://www.readbyqxmd.com/read/28262240/heavy-menstrual-bleeding-an-update-on-management
#5
Joanna Davies, Rezan A Kadir
Heavy menstrual bleeding (HMB) is defined as excessive menstrual blood loss (MBL) >80 mL per cycle, that interferes with a woman's physical, emotional, social wellbeing and quality of life. Aetiology is due to underlying uterine pathologies, coagulopathy, ovulation dysfunction, or iatrogenic. Up to 20% of women with HMB will have an underlying inherited bleeding disorder (IBD). Assessment of HMB should entail a menstrual and gynaecological history and a bleeding score to distinguish those women who require additional haematological investigations...
March 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28258748/restoring-ecological-properties-of-acidic-soils-contaminated-with-elemental-sulfur
#6
Michael R McTee, Ylva Lekberg, Lorinda Bullington, Alexii Rummel, Daniel L Mummey, Philip W Ramsey, Nancy W Hinman
Elemental sulfur (S(0)) accumulates in the environment from anthropogenic sources as a byproduct from oil and gas refining and from trap and skeet shooting targets. Bacteria can oxidize S(0) to H2SO4, which acidifies soil. We explored whether combinations of soil amendments can be used to remediate acidic soils contaminated with S(0) by restoring soil chemistry, plant growth, and bacterial communities in a greenhouse. Results were compared to a contamination gradient in a field that had been limed with CaMg(CO3)2 two years prior...
February 28, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28248294/a-wolbachia-deubiquitylating-enzyme-induces-cytoplasmic-incompatibility
#7
John F Beckmann, Judith A Ronau, Mark Hochstrasser
Wolbachia are obligate intracellular bacteria(1) that infect arthropods, including approximately two-thirds of insect species(2). Wolbachia manipulate insect reproduction by enhancing their inheritance through the female germline. The most common alteration is cytoplasmic incompatibility (CI)(3-5), where eggs from uninfected females fail to develop when fertilized by sperm from Wolbachia-infected males. By contrast, if female and male partners are both infected, embryos are viable. CI is a gene-drive mechanism impacting population structure(6) and causing reproductive isolation(7), but its molecular mechanism has remained unknown...
March 1, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28238020/haploid-embryo-production-in-rice-and-maize-induced-by-psasgr-bbml-transgenes
#8
Joann A Conner, Maricel Podio, Peggy Ozias-Akins
The PsASGR - BBML transgene, derived from a wild apomictic grass species, can induce parthenogenesis, embryo formation without fertilization, in rice and maize, leading to the formation of haploid plants. The ability to engineer apomictic crop plants using genes identified from naturally occurring apomicts will depend on the ability of those genes to function in crop plants. The PsASGR-BBML transgene, derived from the apomictic species Pennisetum squamulatum, promotes parthenogenesis in sexual pearl millet, a member of the same genus, leading to the formation of haploid embryos...
March 2017: Plant Reproduction
https://www.readbyqxmd.com/read/28228092/variation-in-rates-of-spontaneous-male-production-within-the-nematode-species-pristionchus-pacificus-supports-an-adaptive-role-for-males-and-outcrossing
#9
Katy Morgan, Angela McGaughran, Christian Rödelsperger, Ralf J Sommer
BACKGROUND: The nematode species Pristionchus pacificus has an androdioecious mating system in which populations consist of self-fertilizing hermaphrodites and relatively few males. The prevalence of males in such a system is likely to depend on the relative pros and cons of outcrossing. While outcrossing generates novel allelic combinations and can therefore increase adaptive potential, it may also disrupt the potentially beneficial consequences of repeated generations of selfing. These include purging of deleterious alleles, inheritance of co-adapted allele complexes, improved hermaphrodite fitness and increased population growth...
February 23, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/28226241/catsper%C3%AE-regulates-the-structural-continuity-of-sperm-ca-2-signaling-domains-and-is-required-for-normal-fertility
#10
Jean-Ju Chung, Kiyoshi Miki, Doory Kim, Sang-Hee Shim, Huanan F Shi, Jae Yeon Hwang, Xinjiang Cai, Yusuf Iseri, Xiaowei Zhuang, David E Clapham
We report that the Gm7068 (CatSpere) and Tex40 (CatSperz) genes encode novel subunits of a 9-subunit CatSper ion channel complex. Targeted disruption of CatSperz reduces CatSper current and sperm rheotactic efficiency in mice, resulting in severe male subfertility. Normally distributed in linear quadrilateral nanodomains along the flagellum, the complex lacking CatSperζ is disrupted at ~0.8 μm intervals along the flagellum. This disruption renders the proximal flagellum inflexible and alters the 3D flagellar envelope, thus preventing sperm from reorienting against fluid flow in vitro and efficiently migrating in vivo...
February 23, 2017: ELife
https://www.readbyqxmd.com/read/28215678/the-impact-of-ovarian-stimulation-protocol-on-oocyte-quality-subsequent-in%C3%A2-vitro-embryo-development-and-pregnancy-after-transfer-to-recipients-in-eld-s-deer-rucervus-eldii-thamin
#11
Ampika Thongphakdee, Debra K Berg, Theerawat Tharasanit, Nikorn Thongtip, Wanlaya Tipkantha, Chainarong Punkong, Daraka Tongthainan, Sakhon Noimoon, Umaporn Maikeaw, Nudthakamol Kajornklin, Boripat Siriaroonrat, Pierre Comizzoli, Sumate Kamolnorranath
Propagating genetically valuable individuals through oocyte collection, in vitro fertilization (IVF) and embryo transfer is critical to maintain sustainable populations of the endangered Eld's deer. The objectives of this study were to assess the impact of exogenous FSH injections on (1) the number and in vitro competence of oocytes collected and (2) the developmental potential of resulting IVF embryos after transfer into recipients during the breeding season (February-April). In a pilot experiment, estrus synchronization was conducted in three surplus females (using intravaginal progesterone-releasing devices, CIDRG for 14 days and injections of buserelin (a GnRH agonist)...
March 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/28208955/high-serum-estradiol-and-heavy-metals-responsible-for-human-spermiation-defect-a-pilot-study
#12
Manish Jain, Amanpreet Kaur Kalsi, Amita Srivastava, Yogendra Kumar Gupta, Ashutosh Halder
INTRODUCTION: Spermiation is a process of releasing sperm into the lumen of seminiferous tubules. Failure in releasing sperm into the lumen is designated as spermiation defect. Spermiation defect cases present as oligo-azoospermia or azoospermia despite normal gonadotropins and testicular histology/cytology. Human spermiation defect never got attention to investigate infertility practice. Most of the information on spermiation defect, so far is from animal experiments. We assume some cases of non-obstructive azoospermia with normal gonadotropins and testicular histology/cytology could be due to spermiation defect...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28188594/extracellular-micrornas-in-follicular-fluid-and-their-potential-association-with-oocyte-fertilization-and-embryo-quality-an-exploratory-study
#13
Ronit Machtinger, Rodosthenis S Rodosthenous, Michal Adir, Abdallah Mansour, Catherine Racowsky, Andrea A Baccarelli, Russ Hauser
PURPOSE: The purpose of this study is to determine the profile of extracellular microRNAs (exmiRNAs) in follicular fluid (FF) and explore their association with fertilization potential and embryo quality. METHODS: We collected FF from single follicles containing mature oocytes from 40 women undergoing IVF and we screened for the expression of 754 exmiRNAs in FF using the TaqMan OpenArray® qPCR platform. To determine the association of exmiRNAs and IVF outcomes, we compared their expression levels in FF samples that differ by fertilization status (normally, abnormally, and failed to fertilize) and embryo quality (top vs...
February 10, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28148467/comparison-of-fertility-of-liquid-or-frozen-semen-when-varying-the-interval-from-cidr-removal-to-insemination
#14
Brittany N Richardson, Erin L Larimore, Julie A Walker, Matthew D Utt, J Mel DeJarnette, George A Perry
Cryopreservation allows for long-term storage of semen; however, it leads to damage of sperm that may result in complete loss of viability or changes that possibly decrease sperm functionality. Liquid semen is not exposed to these stressors and may result in a longer lifespan in the female reproductive tract, thus increasing the range in timing of insemination without affecting fertility. The objective of this study was to compare fertility of liquid and frozen semen when varying the interval from CIDR removal to AI using the 7-day CO-Synch+CIDR protocol for synchronization of time of estrus...
March 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28137808/two-novel-calcium-dependent-kinase-1-inhibitors-interfere-with-vertical-transmission-in-mice-infected-with-neospora-caninum-tachyzoites
#15
Joachim Müller, Adriana Aguado-Martínez, Vreni Balmer, Dustin J Maly, Erkang Fan, Luis-Miguel Ortega-Mora, Kayode K Ojo, Wesley C Van Voorhis, Andrew Hemphill
We present the effects of two novel bumped kinase inhibitors, BKI-1517 and BKI-1553 against Neospora caninum tachyzoites in vitro and in experimentally infected pregnant mice. The compounds inhibited tachyzoite proliferation of a transgenic beta-galactosidase reporter strain cultured in human foreskin fibroblasts with IC50 values of 0.05 ± 0.03 and 0.18 ± 0.03 μM, respectively. As assessed by Alamar blue assay, fibroblast IC50 values were above 20 μM, however, morphological changes occurred in cultures treated with more than 5 μM BKI-1517 after prolonged (>6 days) exposure...
January 30, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28123059/overactivation-of-hedgehog-signaling-in-the-developing-m%C3%A3-llerian-duct-interferes-with-duct-regression-in-males-and-causes-subfertility
#16
Fernando F Migone, Pei-Hsuan Hung, Robert G Cowan, Vimal Selvaraj, Susan S Suarez, Susan M Quirk
The influence of the hedgehog signaling pathway on reproduction was studied in transgenic mice in which a dominant active allele of the hedgehog signal transducer, smoothened (Smo), was conditionally expressed in the developing Müllerian duct and gonads through recombination mediated by anti-Müllerian hormone receptor 2-cre (Amhr2(cre) ). Previous studies showed that development of the oviduct and uterus are abnormal in female Amhr2(cre/+)SmoM2 mice. In the current study, focusing on mutant males, litter size was reduced 53% in crosses with wild-type females...
April 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28121646/minimally-invasive-myomectomy
#17
Rebecca Flyckt, Kathryn Coyne, Tommaso Falcone
Uterine fibroids can significantly impact a woman's health, fertility, and quality of life. When medical therapy fails, surgery is recommended; the gold standard in uterine-sparing surgery is myomectomy. The evidence-based benefits of minimally invasive myomectomy are detailed in this manuscript. Minimally invasive myomectomy techniques are reviewed, including laparoscopic, robotic-assisted, and laparoscopic or robotic-assisted with mini-laparotomy. Criteria for minimally invasive myomectomy are outlined and preoperative planning is discussed...
January 24, 2017: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28119950/optimizing-inflammatory-bowel-disease-for-successful-in-vitro-fertilization
#18
Jason J Pan, Mora Cannon, Edward Kane, Gauree Konijeti
We present a nulliparous woman with mild to moderate ulcerative colitis (UC) and multiple failed cycles of in vitro fertilization (IVF) in whom we achieved a successful, viable pregnancy following clinical and endoscopic UC remission. Infertile patients with inflammatory bowel disease who have failed multiple cycles of IVF should try to achieve clinical remission and mucosal healing (absence of erosions or ulcers) prior to reattempting conception. Furthermore, deficiencies in vitamin B12, vitamin D, and iron should be addressed...
August 2016: ACG Case Reports Journal
https://www.readbyqxmd.com/read/28114360/extracellular-ca2-is-required-for-fertilization-in-the-african-clawed-frog-xenopus-laevis
#19
Katherine L Wozniak, Brianna L Mayfield, Alexis M Duray, Maiwase Tembo, David O Beleny, Marc A Napolitano, Monica L Sauer, Bennett W Wisner, Anne E Carlson
BACKGROUND: The necessity of extracellular Ca2+ for fertilization and early embryonic development in the African clawed frog, Xenopus laevis, is controversial. Ca2+ entry into X. laevis sperm is reportedly required for the acrosome reaction, yet fertilization and embryonic development have been documented to occur in high concentrations of the Ca2+ chelator BAPTA. Here we sought to resolve this controversy. METHODOLOGY/PRINCIPAL FINDING: Using the appearance of cleavage furrows as an indicator of embryonic development, we found that X...
2017: PloS One
https://www.readbyqxmd.com/read/28104747/the-goddard-and-saturn-genes-are-essential-for-drosophila-male-fertility-and-may-have-arisen-de-novo
#20
Anna M Gubala, Jonathan F Schmitz, Michael J Kearns, Tery T Vinh, Erich Bornberg-Bauer, Mariana F Wolfner, Geoffrey D Findlay
New genes arise through a variety of mechanisms, including the duplication of existing genes and the de novo birth of genes from non-coding DNA sequences. While there are numerous examples of duplicated genes with important functional roles, the functions of de novo genes remain largely unexplored. Many newly evolved genes are expressed in the male reproductive tract, suggesting that these evolutionary innovations may provide advantages to males experiencing sexual selection. Using testis-specific RNA interference, we screened 11 putative de novo genes in Drosophila melanogaster for effects on male fertility and identified two, goddard and saturn, that are essential for spermatogenesis and sperm function...
January 19, 2017: Molecular Biology and Evolution
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