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https://www.readbyqxmd.com/read/28798523/the-second-demographic-transition-theory-a-review-and-appraisal
#1
Batool Zaidi, S Philip Morgan
References to the second demographic transition (SDT) concept/theoretical framework have increased dramatically in the last two decades. The SDT predicts unilinear change toward very low fertility and a diversity of union and family types. The primary driver of these changes is a powerful, inevitable and irreversible shift in attitudes and norms in the direction of greater individual freedom and self-actualization. First, we describe the origin of this framework and its evolution over time. Second, we review the empirical fit of the framework to major changes in demographic and family behavior in the U...
July 2017: Annual Review of Sociology
https://www.readbyqxmd.com/read/28768200/cfp1-regulates-histone-h3k4-trimethylation-and-developmental-potential-in-mouse-oocytes
#2
Chao Yu, Xiaoying Fan, Qian-Qian Sha, Hui-Han Wang, Bo-Tai Li, Xing-Xing Dai, Li Shen, Junping Liu, Lie Wang, Kui Liu, Fuchou Tang, Heng-Yu Fan
Trimethylation of histone H3 at lysine-4 (H3K4me3) is associated with eukaryotic gene promoters and poises their transcriptional activation during development. To examine the in vivo function of H3K4me3 in the absence of DNA replication, we deleted CXXC finger protein 1 (CFP1), the DNA-binding subunit of the SETD1 histone H3K4 methyltransferase, in developing oocytes. We find that CFP1 is required for H3K4me3 accumulation and the deposition of histone variants onto chromatin during oocyte maturation. Decreased H3K4me3 in oocytes caused global downregulation of transcription activity...
August 1, 2017: Cell Reports
https://www.readbyqxmd.com/read/28763725/peroxidized-mineral-oil-increases-the-oxidant-status-of-culture-media-and-inhibits-in%C3%A2-vitro-porcine-embryo-development
#3
C A Martinez, A Nohalez, J J Ceron, C P Rubio, J Roca, C Cuello, H Rodriguez-Martinez, E A Martinez, M A Gil
The use of oils with undetected alterations is a long-recognized problem for in vitro embryo production systems. Since peroxides in oils have been associated with reduced embryo production outcomes, our goals were (1) to evaluate the effects of a batch of mineral oil (MO) that was suspected to be altered on the in vitro production of pig embryos and (2) to determine oil peroxide values throughout culture and the transfer of oxidant agents from oil to culture media. Sunflower oil, which has a completely different chemical composition than MO but a higher oxidative status, and unaltered MO were used as controls...
July 27, 2017: Theriogenology
https://www.readbyqxmd.com/read/28757140/the-feasibility-safety-and-effectiveness-of-hysteroscopic-sterilization-compared-with-laparoscopic-sterilization
#4
Lina Antoun, Paul Smith, Janesh K Gupta, T Justin Clark
BACKGROUND: In contrast to conventional laparoscopic sterilization, newer hysteroscopic approaches avoid the need for hospital admission, general anesthesia, and prolonged recovery. However, there are concerns that the feasibility, safety, and efficacy of hysteroscopic sterilization may be lower than established laparoscopic sterilization. OBJECTIVE: We sought to evaluate the outcomes of hysteroscopic sterilization compared with laparoscopic sterilization in routine clinical practice in a comparative observational cohort study...
July 27, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28742583/endometriosis-and-fertility-preservation
#5
Rebecca Barnett, Nicole Banks, Alan H Decherney
Endometriosis is common, affecting 5% to 10% of reproductive age women. Nearly half of women with surgical evidence of endometriosis fail to achieve spontaneous pregnancy. Surgical treatment of endometriosis can be detrimental to ovarian reserve. In the absence of surgical intervention, ovarian reserve may still be negatively impacted over time. Fertility preservation was developed for women requiring gonadotoxic treatments. Improved methods have led to greater consideration of offering these services to women with other disease processes that threaten ovarian reserve...
September 2017: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28732531/endometrial-scratching-in-women-with-implantation-failure-after-a-first-ivf-icsi-cycle-does-it-lead-to-a-higher-live-birth-rate-the-scratch-study-a-randomized-controlled-trial-ntr-5342
#6
N E van Hoogenhuijze, H L Torrance, F Mol, J S E Laven, E Scheenjes, M A F Traas, C Janssen, B Cohlen, G Teklenburg, J P de Bruin, R van Oppenraaij, J W M Maas, E Moll, K Fleischer, M H van Hooff, C de Koning, A Cantineau, C B Lambalk, M Verberg, M Nijs, A P Manger, M van Rumste, L F van der Voet, A Preys-Bosman, J Visser, E Brinkhuis, J E den Hartog, A Sluijmer, F W Jansen, W Hermes, M L Bandell, M J Pelinck, J van Disseldorp, M van Wely, J Smeenk, Q D Pieterse, J C Boxmeer, E R Groenewoud, M J C Eijkemans, J C Kasius, F J M Broekmans
BACKGROUND: Success rates of assisted reproductive techniques (ART) are approximately 30%, with the most important limiting factor being embryo implantation. Mechanical endometrial injury, also called 'scratching', has been proposed to positively affect the chance of implantation after embryo transfer, but the currently available evidence is not yet conclusive. The primary aim of this study is to determine the effect of endometrial scratching prior to a second fresh in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycle on live birth rates in women with a failed first IVF/ICSI cycle...
July 21, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28727763/loss-of-receptor-activity-modifying-protein-2-in-mice-causes-placental-dysfunction-and-alters-pth1r-regulation
#7
Mahita Kadmiel, Brooke C Matson, Scott T Espenschied, Patricia M Lenhart, Kathleen M Caron
Receptor activity-modifying protein 2 (Ramp2) is a single-pass transmembrane protein that heterodimerizes with several family B G-protein coupled receptors to alter their function. Ramp2 has been primarily characterized in association with calcitonin receptor-like receptor (Calcrl, CLR), forming the canonical receptor complex for the endocrine peptide adrenomedullin (Adm, AM). However, we previously demonstrated that Ramp2+/- female mice display a constellation of endocrine-related phenotypes that are distinct from those of Adm+/- and Calcrl+/- mice, implying that RAMP2 has physiological functions beyond its canonical complex...
2017: PloS One
https://www.readbyqxmd.com/read/28724622/transcription-factor-myb26-is-key-to-spatial-specificity-in-anther-secondary-thickening-formation
#8
Caiyun Yang, Jie Song, Alison Ferguson, Doris Klisch, Kim Simpson, Rui Mo, Benjamin Taylor, Zoe A Wilson
Successful fertilisation relies on the production and effective release of viable pollen. Failure of anther opening (dehiscence), results in male sterility although the pollen may be fully functional. MYB26 regulates the formation of secondary thickening in the anther endothecium, which is critical for anther dehiscence and fertility. Here we show that the although the MYB26 transcript shows expression in multiple floral organs the MYB26 protein is localised specifically to the anther endothecium nuclei and that it directly regulates two NAC domain genes, NST1 and NST2, which are critical for the induction of secondary thickening biosynthesis genes...
July 19, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28724183/physiological-intra-cytoplasmic-sperm-injection-picsi-outcomes-after-oral-pretreatment-and-semen-incubation-with-myo-inositol-in-oligoasthenoteratozoospermic-men-results-from-a-prospective-randomized-controlled-trial
#9
T Korosi, C Barta, K Rokob, T Torok
OBJECTIVE: The aim of the current study was to evaluate the effect of an oral pretreatment with a mix of myo-inositol (Myo-Ins), folic acid, vitamin E, L-carnitine, L-arginine and selenium (Folandrol, Exeltis, Hungary) and subsequent direct Myo-Ins incubation of spermatozoa before Physiological Intra-Cytoplasmic Sperm Injection (PICSI) procedures in infertile couples due to oligoasthenoteratozoospermia with previous failed PICSI procedures. PATIENTS AND METHODS: We performed a prospective, randomized controlled trial at the Assisted Reproduction Unit of the Kaáli Institute (Győr, Hungary)...
June 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28718159/the-role-of-varicocele-in-male-factor-subfertility
#10
REVIEW
Dillon Sedaghatpour, Boback M Berookhim
PURPOSE OF REVIEW: Varicocele may play a significant role in a subset of patients presenting with male factor infertility. Despite its relatively high prevalence amongst subfertile men, there has been controversy over the effectiveness of surgical treatments, patient selection, and when to administer treatment, particularly in the era of assisted reproductive technology. RECENT FINDINGS: In line with earlier finding, recent evidence strongly suggests that varicocelectomy improves pregnancy rates and semen parameters...
September 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28717717/management-and-care-of-women-with-invasive-cervical-cancer-american-society-of-clinical-oncology-resource-stratified-clinical-practice-guideline
#11
Linus T Chuang, Sarah Temin, Rolando Camacho, Alfonso Dueñas-Gonzalez, Sarah Feldman, Murat Gultekin, Vandana Gupta, Susan Horton, Graciela Jacob, Elizabeth A Kidd, Kennedy Lishimpi, Carolyn Nakisige, Joo-Hyun Nam, Hextan Yuen Sheung Ngan, William Small, Gillian Thomas, Jonathan S Berek
PURPOSE: To provide evidence-based, resource-stratified global recommendations to clinicians and policymakers on the management and palliative care of women diagnosed with invasive cervical cancer. METHODS: ASCO convened a multidisciplinary, multinational panel of cancer control, medical and radiation oncology, health economic, obstetric and gynecologic, and palliative care experts to produce recommendations reflecting resource-tiered settings. A systematic review of literature from 1966 to 2015 failed to yield sufficiently strong quality evidence to support basic- and limited-resource setting recommendations; a formal consensus-based process was used to develop recommendations...
October 2016: Journal of Global Oncology
https://www.readbyqxmd.com/read/28716426/hormone-dependent-uterine-epithelial-stromal-communication-for-pregnancy-support
#12
Xiaoqiu Wang, San-Pin Wu, Francesco J DeMayo
Human fertility is a relatively inefficient process. Despite the presence of visibly healthy embryos, 30% of pregnancies generated by assisted reproductive technology (ART) fail before the second trimester. The uterine microenvironment plays a critical role in establishing and maintaining a successful pregnancy that requires coordinated communication between the epithelial and stromal cells of the endometrium. The epithelial cells must cease proliferation and become permissive for the conceptus (embryo and associated extraembryonic membranes), while the stromal cells undergoes mesenchymal-to-epithelioid transformation to form the decidua in support of subsequent embryo development...
July 6, 2017: Placenta
https://www.readbyqxmd.com/read/28711606/ovarian-aromatase-loss-of-function-mutant-medaka-undergo-ovary-degeneration-and-partial-female-to-male-sex-reversal-after-puberty
#13
Masatoshi Nakamoto, Yasushi Shibata, Kaoru Ohno, Takeshi Usami, Yasuhiro Kamei, Yoshihito Taniguchi, Takeshi Todo, Takashi Sakamoto, Graham Young, Penny Swanson, Kiyoshi Naruse, Yoshitaka Nagahama
Although estrogens have been generally considered to play a critical role in ovarian differentiation in non-mammalian vertebrates, the specific functions of estrogens during ovarian differentiation remain unclear. We isolated two mutants with premature stops in the ovarian aromatase (cyp19a1) gene from an N-ethyl-N-nitrosourea-based gene-driven mutagenesis library of the medaka, Oryzias latipes. In XX mutants, gonads first differentiated into normal ovaries containing many ovarian follicles that failed to accumulate yolk...
July 12, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28706368/knowledge-and-behaviour-regarding-birth-prevention-of-healthcare-providers
#14
Smriti Bhargava, Nupur Hooja, Rajani Nawal, Bhomraj Kumawat, Avantika Sharma, Richa Manish
INTRODUCTION: Healthcare providers are an important link with the general public to impart knowledge regarding contraception. They are an important source of providing information regarding different methods of contraception, their proper use and removing the myths from the couple's mind. However, their own attitude and practice of contraception are often lacking. OBJECTIVE: This study was conducted to assess the attitude and practice of contraception over the last 1 year of nurses in a tertiary care hospital in Jaipur...
August 2017: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/28701212/is-the-oocyte-quality-affected-by-endometriosis-a-review-of-the-literature
#15
REVIEW
Ana Maria Sanchez, Valeria Stella Vanni, Ludovica Bartiromo, Enrico Papaleo, Eran Zilberberg, Massimo Candiani, Raoul Orvieto, Paola Viganò
Endometriosis is an estrogen-dependent chronic inflammatory condition that affects women in their reproductive period causing infertility and pelvic pain. The disease, especially at the ovarian site has been shown to have a detrimental impact on ovarian physiology. Indeed, sonographic and histologic data tend to support the idea that ovarian follicles of endometriosis patients are decreased in number and more atretic. Moreover, the local intrafollicular environment of patients affected is characterized by alterations of the granulosa cell compartment including reduced P450 aromatase expression and increased intracellular reactive oxygen species generation...
July 12, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28694258/plc%C3%AE-is-the-physiological-trigger-of-the-ca-2-oscillations-that-induce-embryogenesis-in-mammals-but-conception-can-occur-in-its-absence
#16
Alaa Hachem, Jonathan Godwin, Margarida Ruas, Hoi Chang Lee, Minerva Ferrer Buitrago, Goli Ardestani, Andrew Bassett, Sebastian Fox, Felipe Navarrete, Petra de Sutter, Björn Heindryckx, Rafael Fissore, John Parrington
Activation of the egg by the sperm is the first, vital stage of embryogenesis. The sperm protein PLCζ has been proposed as the physiological agent that triggers the Ca(2+) oscillations that normally initiate embryogenesis. Consistent with this, recombinant PLCζ induces Ca(2+) oscillations in eggs and debilitating mutations in the PLCZ1 gene are associated with infertility in men. However, there has been no evidence that knockout of the gene encoding PLCζ abolishes the ability of sperm to induce Ca(2+) oscillations in eggs...
August 15, 2017: Development
https://www.readbyqxmd.com/read/28674502/treatment-of-abnormal-vaginal-microbiota-before-frozen-embryo-transfer-case-report-and-minireview-to-discuss-the-longitudinal-treatment-efficacy-of-oral-clindamycin
#17
Thor Haahr, Helle O Elbaek, Rita J Laursen, Birgit Alsbjerg, Jørgen S Jensen, Peter Humaidan
Abnormal vaginal microbiota (AVM) or bacterial vaginosis (BV) might negatively impact reproductive outcomes of in vitro fertilization (IVF). However, before randomized controlled trials are initiated to investigate cause and effect, it is necessary to establish the optimal treatment for AVM. Metronidazole seems ineffective to treat the biofilm in AVM; thus, clindamycin could be suggested as a relevant antibiotic agent for future intervention based studies. In the present case report, we present the first longitudinal follow-up of the vaginal microbiota with molecular methods during and after oral clindamycin treatment...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28663368/betaine-is-accumulated-via-transient-choline-dehydrogenase-activation-during-mouse-oocyte-meiotic-maturation
#18
Taylor McClatchie, Megan Meredith, Mariame O Ouédraogo, Sandy Slow, Michael Lever, Mellissa R W Mann, Steven H Zeisel, Jacquetta M Trasler, Jay M Baltz
Betaine (N,N,N-trimethylglycine) plays key roles in mouse eggs and preimplantation embryos first in a novel mechanism of cell volume regulation and second as a major methyl donor in blastocysts, but its origin is unknown. Here, we determined that endogenous betaine was present at low levels in germinal vesicle (GV) stage mouse oocytes before ovulation, but reached high levels in the mature, ovulated egg. However, no betaine transport into oocytes was detected during meiotic maturation. Since betaine can be synthesized in mammalian cells via choline dehydrogenase (CHDH; EC1...
June 29, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28656538/the-dilemma-of-counseling-patients-about-poor-prognosis-live-birth-after-ivf-with-autologous-oocytes-in-a-43-year-old-woman-with-fsh-levels-above-30%C3%A2-miu-ml
#19
Heather R Burks, Marsha Baker, Alexander M Quaas, Kristin A Bendikson, Karine Chung, Richard J Paulson
Providing reasonable expectations to patients with diminished ovarian reserve prior to attempting pregnancy through in vitro fertilization (IVF) is one of the most challenging aspects of fertility care. In some instances, advice from the clinician to pursue more effective treatment, such as donor oocytes, may not be acceptable to the patient. In this case report, a patient is presented who represents a poor prognosis candidate for IVF treatment. She was 43 years old with six prior failed IVF cycles and repetitive basal FSH values above 30 mIU/mL...
June 27, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28652594/self-diploidization-of-human-haploid-parthenogenetic-embryos-through-the-rho-pathway-regulates-endomitosis-and-failed-cytokinesis
#20
Lizhi Leng, Qi Ouyang, Xiangyi Kong, Fei Gong, Changfu Lu, Lei Zhao, Yun Shi, Dehua Cheng, Liang Hu, Guangxiu Lu, Ge Lin
A diploid genome is necessary for normal mammalian development, thus haploid parthenogenetic embryos undergo frequent self-diploidization during preimplantation development; however, the underlying mechanism is unclear. In this study, time-lapse recording revealed that human haploid parthenotes (HPs) undergo self-diploidization via failed cytokinesis (FC) and endomitosis (EM). The frequencies of FC/EM were significantly higher in HPs than in normal fertilized embryos (26.3% vs. 1.6%, P < 0.01; 19.7% vs...
June 26, 2017: Scientific Reports
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