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Ferric fang

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https://www.readbyqxmd.com/read/29053793/2017-infectious-diseases-society-of-america-infectious-diarrhea-guidelines-a-view-from-the-clinical-laboratory
#1
Ferric C Fang, Robin Patel
No abstract text is available yet for this article.
October 19, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28667369/dft-studies-of-the-substituent-effects-of-dimethylamino-on-non-heme-active-oxidizing-species-iron-v-oxo-species-or-iron-iv-oxo-acetate-aminopyridine-cation-radical-species
#2
Fang Wang, Wei Sun, Chungu Xia, Yong Wang
Through the introduction of dimethylamino (Me2N) substituent at the pyridine ring of 2-((R)-2-[(R)-1-(pyridine-2-ylmethyl)pyrrolidin-2-yl]pyrrolidin-1-ylmethyl)pyridine (PDP) ligand, the non-heme Fe(II)((Me2N)PDP)/H2O2/AcOH catalyst system was found to exhibit significant higher catalytic activity and enantioselectivity than the non-substituent one in the asymmetric epoxidation experiments. The mechanistic origin of the remarkable substituent effects in these oxidation reactions has not been well established...
October 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28588134/the-rcs-regulated-colanic-acid-capsule-maintains-membrane-potential-in-salmonella-enterica-serovar-typhimurium
#3
Jasmine M Pando, Joyce E Karlinsey, Jimmie C Lara, Stephen J Libby, Ferric C Fang
The Rcs phosphorelay and Psp (phage shock protein) systems are envelope stress responses that are highly conserved in gammaproteobacteria. The Rcs regulon was found to be strongly induced during metal deprivation of Salmonella enterica serovar Typhimurium lacking the Psp response. Nineteen genes activated by the RcsA-RcsB response regulator make up an operon responsible for the production of colanic acid capsular polysaccharide, which promotes biofilm development. Despite more than half a century of research, the physiological function of colanic acid has remained elusive...
June 6, 2017: MBio
https://www.readbyqxmd.com/read/28443246/genetic-and-dietary-iron-overload-differentially-affect-the-course-of-salmonella-typhimurium-infection
#4
Manfred Nairz, Andrea Schroll, David Haschka, Stefanie Dichtl, Piotr Tymoszuk, Egon Demetz, Patrizia Moser, Hubertus Haas, Ferric C Fang, Igor Theurl, Günter Weiss
Genetic and dietary forms of iron overload have distinctive clinical and pathophysiological features. HFE-associated hereditary hemochromatosis is characterized by overwhelming intestinal iron absorption, parenchymal iron deposition, and macrophage iron depletion. In contrast, excessive dietary iron intake results in iron deposition in macrophages. However, the functional consequences of genetic and dietary iron overload for the control of microbes are incompletely understood. Using Hfe(+/+) and Hfe(-/-) mice in combination with oral iron overload in a model of Salmonella enterica serovar Typhimurium infection, we found animals of either genotype to induce hepcidin antimicrobial peptide expression and hypoferremia following systemic infection in an Hfe-independent manner...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28438977/47-years-of-iai-a-glance-in-the-mirror-and-the-road-ahead
#5
EDITORIAL
Ferric C Fang
No abstract text is available yet for this article.
July 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28387523/species-specific-risk-factors-treatment-decisions-and-clinical-outcomes-for-laboratory-isolates-of-less-common-nontuberculous-mycobacteria-in-washington-state
#6
Emily S Ford, David J Horne, Javeed A Shah, Carolyn K Wallis, Ferric C Fang, Thomas R Hawn
RATIONALE: Nontuberculous mycobacteria (NTM) are a diverse group of environmental organisms that infrequently cause human disease. Understanding of the epidemiologic and clinical characteristics associated with NTM disease is needed to refine diagnostic and treatment strategies, particularly among the less commonly isolated species. OBJECTIVES: To improve knowledge of geographic variance of NTM species, to correlate detailed clinical information with isolation of specific NTM, and to examine the decision to treat and outcomes for specific NTM...
July 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28195347/characterization-of-ferroptosis-in-murine-models-of-hemochromatosis
#7
COMPARATIVE STUDY
Hao Wang, Peng An, Enjun Xie, Qian Wu, Xuexian Fang, Hong Gao, Zhuzhen Zhang, Yuzhu Li, Xudong Wang, Jiaying Zhang, Guoli Li, Lei Yang, Wei Liu, Junxia Min, Fudi Wang
Ferroptosis is a recently identified iron-dependent form of nonapoptotic cell death implicated in brain, kidney, and heart pathology. However, the biological roles of iron and iron metabolism in ferroptosis remain poorly understood. Here, we studied the functional role of iron and iron metabolism in the pathogenesis of ferroptosis. We found that ferric citrate potently induces ferroptosis in murine primary hepatocytes and bone marrow-derived macrophages. Next, we screened for ferroptosis in mice fed a high-iron diet and in mouse models of hereditary hemochromatosis with iron overload...
August 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28172666/clinical-impact-and-cost-effectiveness-of-xpert-mtb-rif-testing-in-hospitalized-patients-with-presumptive-pulmonary-tuberculosis-in-the-united-states
#8
James F Cowan, Aldine S Chandler, Elizabeth Kracen, David R Park, Carolyn K Wallis, Emelline Liu, Chao Song, David H Persing, Ferric C Fang
Background: Microscopic examination of acid-fast-stained sputum smears is the current standard of care in the United States to determine airborne infection isolation (AII) of inpatients with presumptive pulmonary tuberculosis (PTB). However, nucleic acid amplification testing (NAAT) with the Xpert MTB/RIF assay (Xpert) may be more efficient and less costly. Methods: This prospective observational cohort study enrolled a consecutive sample of 318 AII-eligible inpatients from a public hospital in Seattle, Washington, from March 2012 to October 2013...
February 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28126951/reply-to-on-the-impact-factor-and-the-asm-editorial-policy
#9
Ferric C Fang, Arturo Casadevall
No abstract text is available yet for this article.
February 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28077697/point-counterpoint-what-is-the-optimal-approach-for-detection-of-clostridium-difficile-infection
#10
Ferric C Fang, Christopher R Polage, Mark H Wilcox
INTRODUCTIONIn 2010, we published an initial Point-Counterpoint on the laboratory diagnosis of Clostridium difficile infection (CDI). At that time, nucleic acid amplification tests (NAATs) were just becoming commercially available, and the idea of algorithmic approaches to CDI was being explored. Now, there are numerous NAATs in the marketplace, and based on recent proficiency test surveys, they have become the predominant method used for CDI diagnosis in the United States. At the same time, there is a body of literature that suggests that NAATs lack clinical specificity and thus inflate CDI rates...
March 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27986765/skating-to-where-the-puck-is-going-to-be
#11
EDITORIAL
Robert T Schooley, Ferric C Fang
No abstract text is available yet for this article.
January 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27940948/clinical-impact-and-cost-effectiveness-of-xpert-mtb-rif-testing-in-hospitalized-patients-with-presumptive-pulmonary-tuberculosis-in-the-united-states
#12
James F Cowan, Aldine S Chandler, Elizabeth Kracen, David R Park, Carolyn K Wallis, Emelline Liu, Chao Song, David H Persing, Ferric C Fang
BACKGROUND: Microscopic examination of acid-fast stained sputum smears is the current standard of care in the United States to determine airborne infection isolation (AII) of inpatients with presumptive pulmonary tuberculosis (PTB). However, nucleic acid amplification testing (NAAT) with the Xpert® MTB/RIF Assay (Xpert) may be more efficient and less costly. METHOD: This prospective observational cohort study enrolled a consecutive sample of 318 AII-eligible inpatients from a public hospital in Seattle, Washington from March 2012 to October 2013...
December 10, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27933988/niosomes-consisting-of-tween-60-and-cholesterol-improve-the-chemical-stability-and-antioxidant-activity-of-epigallocatechin-gallate-under-intestinal-tract-conditions
#13
Rong Liang, Ling Chen, Wallace Yokoyama, Peter A Williams, Fang Zhong
In order to improve the chemical stability and antioxidant activity of (-)-epigallocatechin gallate (EGCG) in the gastrointestinal tract, niosomes composed of Tween-60 and cholesterol were developed to encapsulate EGCG in this investigation. EGCG loaded niosomes with encapsulation efficiency around 76% exhibited a small Z-average diameter about 60 nm. Compared to free EGCG, the EGCG remaining in dialysis tubes was significantly improved for niosomes at pH 2 and 7.4. Meanwhile, the residual EGCG for niosomes increased from 3% to 49% after 2 h incubation in simulated intestinal fluid (SIF)...
December 7, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27892921/an-essential-role-for-bacterial-nitric-oxide-synthase-in-staphylococcus-aureus-electron-transfer-and-colonization
#14
Traci L Kinkel, Smirla Ramos-Montañez, Jasmine M Pando, Daniel V Tadeo, Erin N Strom, Stephen J Libby, Ferric C Fang
Nitric oxide (NO(•)) is a ubiquitous molecular mediator in biology. Many signalling actions of NO(•) generated by mammalian NO(•) synthase (NOS) result from targeting of the haem moiety of soluble guanylate cyclase. Some pathogenic and environmental bacteria also produce a NOS that is evolutionary related to the mammalian enzymes, but a bacterial haem-containing receptor for endogenous enzymatically generated NO(•) has not been identified previously. Here, we show that NOS of the human pathogen Staphylococcus aureus, in concert with an NO(•)-metabolizing flavohaemoprotein, regulates electron transfer by targeting haem-containing cytochrome oxidases under microaerobic conditions to maintain membrane bioenergetics...
November 28, 2016: Nature Microbiology
https://www.readbyqxmd.com/read/27864421/acknowledgment-of-ad-hoc-reviewers
#15
EDITORIAL
Ferric C Fang
No abstract text is available yet for this article.
December 2016: Infection and Immunity
https://www.readbyqxmd.com/read/27834205/rigorous-science-a-how-to-guide
#16
EDITORIAL
Arturo Casadevall, Ferric C Fang
Proposals to improve the reproducibility of biomedical research have emphasized scientific rigor. Although the word "rigor" is widely used, there has been little specific discussion as to what it means and how it can be achieved. We suggest that scientific rigor combines elements of mathematics, logic, philosophy, and ethics. We propose a framework for rigor that includes redundant experimental design, sound statistical analysis, recognition of error, avoidance of logical fallacies, and intellectual honesty...
November 8, 2016: MBio
https://www.readbyqxmd.com/read/27822548/asm-journals-eliminate-impact-factor-information-from-journal-websites
#17
EDITORIAL
Arturo Casadevall, Stefano Bertuzzi, Michael J Buchmeier, Roger J Davis, Harold Drake, Ferric C Fang, Jack Gilbert, Barbara M Goldman, Michael J Imperiale, Philip Matsumura, Alexander J McAdam, Marcela F Pasetti, Rozanne M Sandri-Goldin, Thomas Silhavy, Louis Rice, Jo-Anne H Young, Thomas Shenk
Many scientists attempt to publish their work in a journal with the highest possible journal impact factor (IF). Despite widespread condemnation of the use of journal IFs to assess the significance of published work, these numbers continue to be widely misused in publication, hiring, funding, and promotion decisions (1, 2).
July 2016: MSystems
https://www.readbyqxmd.com/read/27795401/reply-to-improving-microbiology-research-the-problems-are-less-statistical-and-more-biological
#18
Arturo Casadevall, Lee M Ellis, Erika W Davies, Margaret McFall-Ngai, Ferric C Fang
No abstract text is available yet for this article.
October 18, 2016: MBio
https://www.readbyqxmd.com/read/27611332/contemporary-pharyngeal-and-invasive-emm1-and-invasive-emm12-group-a-streptococcus-isolates-exhibit-similar-in-vivo-selection-for-covrs-mutants-in-mice
#19
Wenchao Feng, Mengyao Liu, Daniel G Chen, Rossana Yiu, Ferric C Fang, Benfang Lei
Group A Streptococcus (GAS) causes diverse infections ranging from common pharyngitis to rare severe invasive infections. Invasive GAS isolates can have natural mutations in the virulence regulator CovRS, which result in enhanced expression of multiple virulence genes, suppressed the expression of the protease SpeB, and increased virulence. It is believed that CovRS mutations arise during human infections with GAS carrying wild-type CovRS and are not transmissible. CovRS mutants of invasive GAS of the emm1 genotype arise readily during experimental infection in mice...
2016: PloS One
https://www.readbyqxmd.com/read/27578762/reply-to-funding-by-lottery-political-problems-and-research-opportunities
#20
Arturo Casadevall, Ferric C Fang
No abstract text is available yet for this article.
2016: MBio
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