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Ferric fang

Hao Wang, Peng An, Enjun Xie, Qian Wu, Xuexian Fang, Hong Gao, Zhuzhen Zhang, Yuzhu Li, Xudong Wang, Jiaying Zhang, Guoli Li, Lei Yang, Wei Liu, Junxia Min, Fudi Wang
Ferroptosis is a recently identified iron-dependent form of non-apoptotic cell death implicated in brain, kidney, and heart pathology. However, the biological roles of iron and iron metabolism in ferroptosis remain poorly understood. Here, we studied the functional role of iron and iron metabolism in the pathogenesis of ferroptosis. We found that ferric citrate potently induces ferroptosis in murine primary hepatocytes and bone marrow-derived macrophages (BMDMs). Next, we screened for ferroptosis in mice fed a high-iron diet and in mouse models of hereditary hemochromatosis with iron overload...
February 13, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
James F Cowan, Aldine S Chandler, Elizabeth Kracen, David R Park, Carolyn K Wallis, Emelline Liu, Chao Song, David H Persing, Ferric C Fang
No abstract text is available yet for this article.
February 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Ferric C Fang, Arturo Casadevall
No abstract text is available yet for this article.
February 2017: Infection and Immunity
Ferric C Fang, Christopher R Polage, Mark H Wilcox
INTRODUCTIONIn 2010, we published an initial Point-Counterpoint on the laboratory diagnosis of Clostridium difficile infection (CDI). At that time, nucleic acid amplification tests (NAATs) were just becoming commercially available, and the idea of algorithmic approaches to CDI was being explored. Now, there are numerous NAATs in the marketplace, and based on recent proficiency test surveys, they have become the predominant method used for CDI diagnosis in the United States. At the same time, there is a body of literature that suggests that NAATs lack clinical specificity and thus inflate CDI rates...
March 2017: Journal of Clinical Microbiology
Robert T Schooley, Ferric C Fang
No abstract text is available yet for this article.
January 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
James F Cowan, Aldine S Chandler, Elizabeth Kracen, David R Park, Carolyn K Wallis, Emelline Liu, Chao Song, David H Persing, Ferric C Fang
BACKGROUND: Microscopic examination of acid-fast stained sputum smears is the current standard of care in the United States to determine airborne infection isolation (AII) of inpatients with presumptive pulmonary tuberculosis (PTB). However, nucleic acid amplification testing (NAAT) with the Xpert® MTB/RIF Assay (Xpert) may be more efficient and less costly. METHOD: This prospective observational cohort study enrolled a consecutive sample of 318 AII-eligible inpatients from a public hospital in Seattle, Washington from March 2012 to October 2013...
December 10, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Rong Liang, Ling Chen, Wallace Yokoyama, Peter A Williams, Fang Zhong
In order to improve the chemical stability and antioxidant activity of (-)-epigallocatechin gallate (EGCG) in the gastrointestinal tract, niosomes composed of Tween-60 and cholesterol were developed to encapsulate EGCG in this investigation. EGCG loaded niosomes with encapsulation efficiency around 76% exhibited a small Z-average diameter about 60 nm. Compared to free EGCG, the EGCG remaining in dialysis tubes was significantly improved for niosomes at pH 2 and 7.4. Meanwhile, the residual EGCG for niosomes increased from 3% to 49% after 2 h incubation in simulated intestinal fluid (SIF)...
December 7, 2016: Journal of Agricultural and Food Chemistry
Traci L Kinkel, Smirla Ramos-Montañez, Jasmine M Pando, Daniel V Tadeo, Erin N Strom, Stephen J Libby, Ferric C Fang
Nitric oxide (NO(•)) is a ubiquitous molecular mediator in biology. Many signalling actions of NO(•) generated by mammalian NO(•) synthase (NOS) result from targeting of the haem moiety of soluble guanylate cyclase. Some pathogenic and environmental bacteria also produce a NOS that is evolutionary related to the mammalian enzymes, but a bacterial haem-containing receptor for endogenous enzymatically generated NO(•) has not been identified previously. Here, we show that NOS of the human pathogen Staphylococcus aureus, in concert with an NO(•)-metabolizing flavohaemoprotein, regulates electron transfer by targeting haem-containing cytochrome oxidases under microaerobic conditions to maintain membrane bioenergetics...
November 28, 2016: Nature Microbiology
Ferric C Fang
No abstract text is available yet for this article.
December 2016: Infection and Immunity
Arturo Casadevall, Ferric C Fang
Proposals to improve the reproducibility of biomedical research have emphasized scientific rigor. Although the word "rigor" is widely used, there has been little specific discussion as to what it means and how it can be achieved. We suggest that scientific rigor combines elements of mathematics, logic, philosophy, and ethics. We propose a framework for rigor that includes redundant experimental design, sound statistical analysis, recognition of error, avoidance of logical fallacies, and intellectual honesty...
November 8, 2016: MBio
Arturo Casadevall, Stefano Bertuzzi, Michael J Buchmeier, Roger J Davis, Harold Drake, Ferric C Fang, Jack Gilbert, Barbara M Goldman, Michael J Imperiale, Philip Matsumura, Alexander J McAdam, Marcela F Pasetti, Rozanne M Sandri-Goldin, Thomas Silhavy, Louis Rice, Jo-Anne H Young, Thomas Shenk
Many scientists attempt to publish their work in a journal with the highest possible journal impact factor (IF). Despite widespread condemnation of the use of journal IFs to assess the significance of published work, these numbers continue to be widely misused in publication, hiring, funding, and promotion decisions (1, 2).
July 2016: MSystems
Arturo Casadevall, Lee M Ellis, Erika W Davies, Margaret McFall-Ngai, Ferric C Fang
No abstract text is available yet for this article.
October 18, 2016: MBio
Wenchao Feng, Mengyao Liu, Daniel G Chen, Rossana Yiu, Ferric C Fang, Benfang Lei
Group A Streptococcus (GAS) causes diverse infections ranging from common pharyngitis to rare severe invasive infections. Invasive GAS isolates can have natural mutations in the virulence regulator CovRS, which result in enhanced expression of multiple virulence genes, suppressed the expression of the protease SpeB, and increased virulence. It is believed that CovRS mutations arise during human infections with GAS carrying wild-type CovRS and are not transmissible. CovRS mutants of invasive GAS of the emm1 genotype arise readily during experimental infection in mice...
2016: PloS One
Arturo Casadevall, Ferric C Fang
No abstract text is available yet for this article.
2016: MBio
Arturo Casadevall, Ferric C Fang
Ever since the successful Apollo 11 Moon landing in 1969, a "moonshot" has come to signify a bold effort to achieve a seemingly impossible task. The Obama administration recently called for a moonshot to cure cancer, an initiative that has elicited mixed responses from researchers who welcome additional funding but worry about raising expectations. We suggest that a successful moonshot requires a sufficient understanding of the basic science underlying a problem in question so that efforts can be focused on engineering a solution...
2016: MBio
Arturo Casadevall, Lee M Ellis, Erika W Davies, Margaret McFall-Ngai, Ferric C Fang
The American Academy of Microbiology convened a colloquium to discuss problems in the biological sciences, with emphasis on identifying mechanisms to improve the quality of research. Participants from various disciplines made six recommendations: (i) design rigorous and comprehensive evaluation criteria to recognize and reward high-quality scientific research; (ii) require universal training in good scientific practices, appropriate statistical usage, and responsible research practices for scientists at all levels, with training content regularly updated and presented by qualified scientists; (iii) establish open data at the timing of publication as the standard operating procedure throughout the scientific enterprise; (iv) encourage scientific journals to publish negative data that meet methodologic standards of quality; (v) agree upon common criteria among scientific journals for retraction of published papers, to provide consistency and transparency; and (vi) strengthen research integrity oversight and training...
2016: MBio
Zhenyu Cheng, Yuewei Zhang, Haiyan Song, Hongli Zhou, Fangli Zhong, Haobin Hu, Yu Feng
In this study, optimization of smashing tissue extraction (STE), preliminary chemical characterization and antioxidant activity in vitro of crude polysaccharides (CPS) from Gentiana scabra bge (G. scabra) were investigated. The optimal extraction conditions were determined as follows: sample particle size of 80mesh, solid/liquid ratio of 1:34, extraction voltage of 157.09V and extraction time of 130.38s. Under these conditions, the extraction yield of CPS had reached 15.03±0.14% (n=3). Chemical composition analysis indicated CPS was mainly composed of mannose, rhamnose, galacturonic acid, glcose, galactose, arabinose and fucose in a molar ratio of 1...
December 2016: International Journal of Biological Macromolecules
Melissa J Perry
Melissa Perry served as the president of the American College of Epidemiology from September 2014 to September 2015. This is a written version of her Presidential Address at the 2015 Annual Meeting. Her speech was inspired by a 2014 Wall Street Journal commentary by Dr. Ferric Fang of the Washington University School of Medicine and Dr. Arturo Casadevall of the Albert Einstein College of Medicine of Yeshiva University. They likened the process of submitting a research proposal to the National Institutes of Health to playing the Powerball lottery...
September 2016: Annals of Epidemiology
Yaxin Li, Jianjun Dai, Xiangkai Zhuge, Haojin Wang, Lin Hu, Jianluan Ren, Ling Chen, Dezhi Li, Fang Tang
BACKGROUND: Avian pathogenic Escherichia coli (APEC) causes avian colibacillosis, which results in economic and welfare costs in the poultry industry worldwide. The pathogenesis of avian pathogenic E. coli strains is not well defined. Here, the function of an outer membrane protein encoded by the ireA gene of avian pathogenic E. coli strain DE205B was investigated. RESULTS: The ireA gene was distributed in 32.9 % (46/140) of tested E. coli strains, with high percentages in the phylogenetic ECOR groups B2 (58...
August 17, 2016: BMC Veterinary Research
Ferric C Fang, Elaine R Frawley, Timothy Tapscott, Andrés Vázquez-Torres
For pathogenic bacteria, the ability to sense and respond to environmental stresses encountered within the host is critically important, allowing them to adapt to changing conditions and express virulence genes appropriately. This review considers the diverse molecular mechanisms by which stress conditions are sensed by bacteria, how related signals are discriminated, and how stress responses are integrated, highlighting recent studies in selected bacterial pathogens of clinical relevance.
August 10, 2016: Cell Host & Microbe
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