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https://www.readbyqxmd.com/read/29666519/effect-of-composition-and-storage-time-on-some-physico-chemical-and-rheological-properties-of-probiotic-soy-cheese-spread
#1
Saroj Kumar Giri, Manoj Kumar Tripathi, Nachiket Kotwaliwale
Probiotic soy-cheese spread was prepared by fermenting soymilk with specific probiotic starter culture, and there after processing the coagulated mass. Soy cheese spread samples had more than 109  cfu/g of viable probiotic count at the time of preparation; and had around 17.6% protein, 25.3% fat and 19.8% total soluble sugar. Compared to commercially available dairy cheese spread, probiotic soy cheese spread had significantly higher protein and anti-oxidant activity. Soy cheese spreads, prepared from pure soymilk as well as by mixing with dairy milk, were studied with respect to the differences in their rheological behavior during storage at refrigerated conditions...
May 2018: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29664652/elasticity-in-bubble-rupture
#2
Daniele Tammaro, Rossana Pasquino, M M Villone, Gaetano D'Avino, Vincenzo Ferraro, Ernesto Di Maio, Antonio Langella, Nino Grizzuti, Pier Luca Maffettone
When a Newtonian bubble ruptures, the film retraction dynamics is controlled by the interplay of surface, inertial and viscous forces. In case a viscoelastic liquid is considered, the scenario is enriched by the appearance of a new significant contribution, namely, the elastic force. In this paper, we investigate experimentally the retraction of viscoelastic bubbles inflated at different blowing rates, showing that the amount of elastic energy stored by the liquid film enclosing the bubble depends on the inflation history and, in turn, affects the velocity of film retraction when the bubble is punctured...
April 17, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29662769/human-and-bovine-spinal-disc-mechanics-subsequent-to-trypsin-injection
#3
Jeremy Alsup, Timothy Bishop, Dennis Eggett, Anton E Bowden
Objective: To investigate the biomechanical effects of injections of a protease on the characteristics of bovine coccygeal and human lumbar disc motion segments. Methods: Mechanics of treated tissues were measured immediately after injection and 3 h after injection. Motion segments underwent axial rotation and flexion-extension loading. Results: Stiffness and neutral zone parameters experienced significant changes over time, with bovine tissues more strongly affected than human cadaver tissues...
October 2017: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29662345/stochastic-isotropic-hyperelastic-materials-constitutive-calibration-and-model-selection
#4
L Angela Mihai, Thomas E Woolley, Alain Goriely
Biological and synthetic materials often exhibit intrinsic variability in their elastic responses under large strains, owing to microstructural inhomogeneity or when elastic data are extracted from viscoelastic mechanical tests. For these materials, although hyperelastic models calibrated to mean data are useful, stochastic representations accounting also for data dispersion carry extra information about the variability of material properties found in practical applications. We combine finite elasticity and information theories to construct homogeneous isotropic hyperelastic models with random field parameters calibrated to discrete mean values and standard deviations of either the stress-strain function or the nonlinear shear modulus, which is a function of the deformation, estimated from experimental tests...
March 2018: Proceedings. Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29662018/rheological-and-mechanical-properties-of-thermoresponsive-methylcellulose-calcium-phosphate-based-injectable-bone-substitutes
#5
Öznur Demir Oğuz, Duygu Ege
In this study, a novel injectable bone substitute (IBS) was prepared by incorporating a bioceramic powder in a polymeric solution comprising of methylcellulose (MC), gelatin and citric acid. Methylcellulose was utilized as the polymeric matrix due to its thermoresponsive properties and biocompatibility. 2.5 wt % gelatin and 3 wt % citric acid were added to the MC to adjust the rheological properties of the prepared IBS. Then, 0, 20, 30 and 50 wt % of the bioceramic component comprising tetracalcium phosphate/hydroxyapatite (TTCP/HA), dicalcium phosphate dehydrate (DCPD) and calcium sulfate dehydrate (CSD) were added into the prepared polymeric component...
April 14, 2018: Materials
https://www.readbyqxmd.com/read/29661482/anisotropy-and-spatial-heterogeneity-in-quantitative-ultrasound-parameters-relevance-to-the-study-of-the-human-cervix
#6
Quinton W Guerrero, Helen Feltovich, Ivan M Rosado-Mendez, Lindsey C Carlson, Geng Li, Timothy J Hall
Imaging biomarkers based on quantitative ultrasound can offer valuable information about properties that inform tissue function and behavior such as microstructural organization (e.g., collagen alignment) and viscoelasticity (i.e., compliance). For example, the cervix feels softer as its microstructure remodels during pregnancy, an increase in compliance that can be objectively quantified with shear wave speed and therefore shear wave speed estimation is a potential biomarker of cervical remodeling. Other proposed biomarkers include parameters derived from the backscattered echo signal, such as attenuation and backscattered power loss, because such parameters can provide insight into tissue microstructural alignment and organization...
April 13, 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29661409/anticoagulant-and-side-effects-of-protamine-in-cardiac-surgery-a-narrative-review
#7
REVIEW
C Boer, M I Meesters, D Veerhoek, A B A Vonk
Neutralisation of systemic anticoagulation with heparin in cardiac surgery with cardiopulmonary bypass requires protamine administration. If adequately dosed, protamine neutralises heparin and reduces the risk of postoperative bleeding. However, as its anticoagulant properties are particularly exerted in the absence of heparin, overdosing of protamine may contribute to bleeding and increased transfusion requirements. This narrative review describes the mechanisms underlying the anticoagulant properties and side-effects of protamine, and the impact of protamine dosing on the activated clotting time and point-of-care viscoelastic test results, and explains the distinct protamine dosing strategies in relation to haemostatic activation and postoperative bleeding...
May 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29660601/a-qcm-d-study-of-the-concentration-and-time-dependent-interactions-of-human-ll37-with-model-mammalian-lipid-bilayers
#8
Lindsay D Lozeau, Marsha W Rolle, Terri A Camesano
The human antimicrobial peptide LL37 is promising as an alternative to antibiotics due to its biophysical interactions with charged bacterial lipids. However, its clinical potential is limited due to its interactions with zwitterionic mammalian lipids leading to cytotoxicity. Mechanistic insight into the LL37 interactions with mammalian lipids may enable rational design of less toxic LL37-based therapeutics. To this end, we studied concentration- and time-dependent interactions of LL37 with zwitterionic model phosphatidylcholine (PC) bilayers with quartz crystal microbalance with dissipation (QCM-D)...
April 5, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29660502/the-place-of-fibrinogen-concentrates-in-the-management-of-perioperative-bleeding-a-position-paper-from-the-francophone-working-group-on-perioperative-hemostasis-gihp
#9
REVIEW
Charles Marc Samama, Brigitte Ickx, Yves Ozier, Annick Steib, Sophie Susen, Anne Godier
The consumption of fibrinogen concentrates has been increasing steadily for several years in surgery, trauma and obstetrics. However, data from the literature are conflicting. The French Working Group on Perioperative Haemostasis (GIHP) proposes a position paper based on a narrative review of the literature, and addresses the following questions: - What is the exact role of fibrinogen in haemostasis? - Which rational support for the use of perioperative fibrinogen? - Which thrombotic risk? - What are the most recent professional recommendations on the use of fibrinogen concentrates? Then, evidence-based recommendations are proposed: 1 - It is suggested not to administer prophylactic FC to prevent haemorrhage...
April 13, 2018: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/29658985/using-rotational-thromboelastometry-clot-firmness-at-5-minutes-rotem-%C3%A2-extem-a5-to-predict-massive-transfusion-and-in-hospital-mortality-in-trauma-a-retrospective-analysis-of-1146-patients
#10
J M Kelly, S Rizoli, P Veigas, S Hollands, A Min
Viscoelastic assays such as TEG® and ROTEM® are increasingly used to guide transfusion of blood products. The EXTEM assay maximum clot firmness (MCF) is a ROTEM measure available after 25-29 min used to guide early decisions. EXTEM A10, the clot firmness at 10 min, is an accepted early surrogate, but investigators differ on whether A5, the clot firmness at 5 min, is acceptable. We re-examined this in a retrospective observational analysis of 1146 trauma patients in one centre who had ROTEM data recorded. A5 and A10 both correlated well with maximum clot firmness, with Pearson coefficients of r = 0...
April 16, 2018: Anaesthesia
https://www.readbyqxmd.com/read/29658491/gpu-based-green-s-function-simulations-of-shear-waves-generated-by-an-applied-acoustic-radiation-force-in-elastic-and-viscoelastic-models
#11
Yiqun Yang, Matthew W Urban, Robert J McGough
Shear wave calculations induced by an acoustic radiation force are very time-consuming on desktop computers, and high-performance graphics processing units (GPUs) achieve dramatic reductions in the computation time for these simulations. The acoustic radiation force is calculated using the fast near field method (FNM) and the angular spectrum approach (ASA), and then the shear waves are calculated in parallel with Green's functions on a GPU. This combination enables rapid evaluation of shear waves for push beams with different spatial samplings and for apertures with different f/#...
April 16, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29657338/size-dependent-submerging-of-nanoparticles-in-polymer-melts-effect-of-line-tension
#12
Shanqiu Liu, Anupam Pandey, Joost Duvigneau, Julius Vancso, Jacco H Snoeijer
Adhesion of nanoparticles to polymer films plays a key role in various polymer technologies. Here we report experiments that reveal how silica nanoparticles adhere to a viscoelastic PMMA film above the glass transition temperature. The polymer was swollen with CO2 , closely matching the conditions of nanoparticle-nucleated polymer foaming. It is found that the degree by which the particles sink into the viscoelastic substrate is strongly size dependent and can even lead to complete engulfment for particles of diameter below 12 nm...
April 10, 2018: Macromolecules
https://www.readbyqxmd.com/read/29656073/protective-therapeutic-effects-of-peptide-nanofiber-and-hyaluronic-acid-hybrid-membrane-in-in-vivo-osteoarthritis-model
#13
Elif Arslan, Melis Sardan Ekiz, Cagla Eren Cimenci, Nuray Can, M Hanifi Gemci, Huseyin Ozkan, Mustafa O Guler, Ayse B Tekinay
Osteoarthritis (OA) is a condition where tissue function is lost through a combination of secondary inflammation and deterioration in articular cartilage. One of the most common causes of OA is age-related tissue impairment because of wear and tear due to mechanical erosion. Hyaluronic acid-based viscoelastic supplements have been widely used for the treatment of knee injuries. However, the current formulations of hyaluronic acid are unable to provide efficient healing and recovery. Here, a nanofiber-hyaluronic acid membrane system that was prepared by using a quarter of the concentration of commercially available hyaluronic acid supplement, Hyalgan® , was used for the treatment of an osteoarthritis model, and Synvisc® , which is another commercially available hyaluronic acid containing viscoelastic supplement, was used as a control...
April 12, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29653380/fibroblast-populated-collagen-lattices-exhibit-opposite-biophysical-conditions-by-fibrin-or-hyaluronic-acid-supplementation
#14
Mario Chopin-Doroteo, Rosa M Salgado-Curiel, José Pérez-González, Benjamín M Marín-Santibáñez, Edgar Krötzsch
Fibrin and hyaluronic acid are important components of the provisional wound matrix. Through interactions with fibroblasts, they provide biophysical cues that regulate the viscoelastic properties of the extracellular matrix. To understand the roles of fibrin and hyaluronic acid in a collagenous environment, we used fibroblast populated collagen lattices (collagen, collagen-fibrin, and collagen-hyaluronic acid). Compared with collagen and collagen-hyaluronic acid cultures, collagen-fibrin cultures showed less contraction, which is correlated with increased elastic (G') and complex (|G*|) moduli, and reduced proportions of dendritic fibroblasts, despite increased αv integrin expression...
March 31, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29652806/excessive-extracellular-atp-desensitizes-p2y2-and-p2x4-atp-receptors-provoking-surfactant-impairment-ending-in-ventilation-induced-lung-injury
#15
REVIEW
Djo Hasan, Joshua Satalin, Philip van der Zee, Michaela Kollisch-Singule, Paul Blankman, Atsuko Shono, Peter Somhorst, Corstiaan den Uil, Han Meeder, Toru Kotani, Gary F Nieman
Stretching the alveolar epithelial type I (AT I) cells controls the intercellular signaling for the exocytosis of surfactant by the AT II cells through the extracellular release of adenosine triphosphate (ATP) (purinergic signaling). Extracellular ATP is cleared by extracellular ATPases, maintaining its homeostasis and enabling the lung to adapt the exocytosis of surfactant to the demand. Vigorous deformation of the AT I cells by high mechanical power ventilation causes a massive release of extracellular ATP beyond the clearance capacity of the extracellular ATPases...
April 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29651853/oleogel-s10-to-accelerate-healing-of-donor-sites-monocentric-results-of-phase-iii-clinical-trial
#16
B Lipový, M Fiamoli, R Mager, Z Jelínková, J Jarkovský, Z Chaloupková, J Holoubek, I Suchánek, P Brychta
MATERIAL AND METHODS: Oleogel-S10, an ointment containing betulin-rich triterpene dry extract from birch bark was tested in an open, blindly evaluated, prospective, controlled, randomized multicentre study to improve wound healing in donor sites. The primary endpoint was time to wound closure, and secondary endpoints were scar related measurements at the time of wound closure, and 3 and 12 months after wound closure (POSAS, laser speckle contrast analysis, viscoelastic analysis). RESULTS: We report the results from a single centre (Department of Burns and Reconstructive Surgery, University Hospital Brno) of this phase III clinical trial...
2018: Acta Chirurgiae Plasticae
https://www.readbyqxmd.com/read/29649240/a-bayesian-approach-to-modelling-the-impact-of-hydrodynamic-shear-stress-on-biofilm-deformation
#17
Oluwole K Oyebamiji, Darren J Wilkinson, Pahala Gedara Jayathilake, Steve P Rushton, Ben Bridgens, Bowen Li, Paolo Zuliani
We investigate the feasibility of using a surrogate-based method to emulate the deformation and detachment behaviour of a biofilm in response to hydrodynamic shear stress. The influence of shear force, growth rate and viscoelastic parameters on the patterns of growth, structure and resulting shape of microbial biofilms was examined. We develop a statistical modelling approach to this problem, using combination of Bayesian Poisson regression and dynamic linear models for the emulation. We observe that the hydrodynamic shear force affects biofilm deformation in line with some literature...
2018: PloS One
https://www.readbyqxmd.com/read/29648837/rheology-of-ultra-swollen-bicontinuos-lipidic-cubic-phases
#18
Chiara Speziale, Reza Ghanbari, Raffaele Mezzenga
Rheological studies of liquid crystalline systems based on monopalmitolein and 5 or 8% of 1,2 distearoylphosphatidylglycerol are reported. Such cubic phases have been shown to possess unusually large water channels, due to their ability of accommodating up to 80% wt of water, a feature that renders these systems suitable for crystallizing membrane proteins with large extra-cellular domains. Their mechanical properties are supposed to be substantially different from those of traditional cubic phases. Rheological measurements were carried out on cubic phases of both Pn3m and Ia3d symmetries...
April 12, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29644843/non-covalently-assembled-electroconductive-hydrogel
#19
Yong Xu, Xuegeng Yang, Alvin Kuriakose Thomas, Panagiotis A Patsis, Thomas Kurth, Martin Kraeter, Kerstin Eckert, Martin Bornhauser, Yixin Zhang
To crosslink biomolecules with electroconductive nanostructures through non-covalent interaction can result in modular networks with defined biological functions and physical properties such as electric conductivity and viscoelasticity. Moreover, the resulting matrices can exhibit interesting features caused by the dynamic assembling process, such as self-healing and molecular ordering. In this paper, we present a physical hydrogel system formed by mixing peptide-polyethylene glycol (peptide-PEG) and poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS)...
April 12, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29643478/mucin-gel-assembly-is-controlled-by-a-collective-action-of-non-mucin-proteins-disulfide-bridges-ca-2-mediated-links-and-hydrogen-bonding
#20
Oliver W Meldrum, Gleb E Yakubov, Mauricio R Bonilla, Omkar Deshmukh, Michael A McGuckin, Michael J Gidley
Mucus is characterized by multiple levels of assembly at different length scales which result in a unique set of rheological (flow) and mechanical properties. These physical properties determine its biological function as a highly selective barrier for transport of water and nutrients, while blocking penetration of pathogens and foreign particles. Altered integrity of the mucus layer in the small intestine has been associated with a number of gastrointestinal tract pathologies such as Crohn's disease and cystic fibrosis...
April 11, 2018: Scientific Reports
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