Oluwaseun A Sobowale, Isabel C Hostettler, Teddy Y Wu, Calvin Heal, Duncan Wilson, Darshan G Shah, Daniel Strbian, Jukka Putaala, Turgut Tatlisumak, Andy Vail, Gagan Sharma, Stephen M Davis, David J Werring, Atte Meretoja, Stuart M Allan, Adrian R Parry-Jones
BACKGROUND: The relationship between baseline perihematomal edema (PHE) and inflammation, and their impact on survival after intracerebral hemorrhage (ICH) are not well understood. OBJECTIVE: Assess the association between baseline PHE, baseline C-reactive protein (CRP), and early death after ICH. METHODS: Analysis of pooled data from multicenter ICH registries. We included patients presenting within 24 h of symptom onset, using multifactorial linear regression model to assess the association between CRP and edema extension distance (EED), and a multifactorial Cox regression model to assess the association between CRP, PHE volume and 30-day mortality...
2024: Frontiers in Neurology