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https://www.readbyqxmd.com/read/28749076/serum-and-gene-expression-levels-of-ct-1-il-6-and-tnf-%C3%AE-after-a-lifestyle-intervention-in-obese-children
#1
A Marti, L Morell-Azanza, T Rendo-Urteaga, S García-Calzón, A Ojeda-Rodríguez, N Martín-Calvo, M J Moreno-Aliaga, J A Martínez, M C Azcona-San Julián
BACKGROUND: Inflammation related molecules such as tumor necrosis factor-α (TNF-α), interleukin 6 (IL-6), and cardiotrophin-1 (CT-1) are highly expressed in obese individuals and could partly explain some comorbidities associated to obesity. In obese children, lifestyle interventions are able to lower inflammation and reduce cardiovascular risk factors associated with obesity. The aim of the present work was to study changes in inflammation-related molecules serum and peripheral blood mononuclear cells (PBMC) transcript levels after a 10-week lifestyle intervention in obese children and asses their potential association with glucose metabolism...
July 27, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28748694/bilayered-nanoparticles-with-sequential-release-of-vegf-gene-and-paclitaxel-for-restenosis-inhibition-in-atherosclerosis
#2
Xiaowei Zhu, Hongzhi Xie, Xiaoyu Liang, Xuanling Li, Jianwei Duan, Yongxia Chen, Ziying Yang, Chao Liu, Cuiwei Wang, Hailing Zhang, Quan Fang, Hongfan Sun, Chen Li, Yongjun Li, Chun Wang, Cunxian Song, Yong Zeng, Jing Yang
Complete re-endothelialization followed by inhibition of smooth muscle cell proliferation is considered an effective therapeutic option to prevent restenosis. We have designed poly(lactide-co-glycolide)-loaded bilayered nanoparticles (NPs) with the ability to sequentially release VEGF-encoding plasmids from the outer layer and paclitaxel (PTX) from the core to promote endothelial regeneration while also prevent restenosis. Comparing with conventional NPs, which release VEGF plasmid and PTX simultaneously, we expect that the bilayered NPs could release the VEGF plasmid more rapidly followed by a delayed release of PTX, resulting in efficient VEGF gene transfection, which ideally could promote re-endothelialization while inhibit excessive smooth muscle cell growth...
July 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28748514/a-systemic-review-and-meta-analysis-of-the-clinical-efficacy-and-safety-of-total-glucosides-of-peony-combined-with-methotrexate-in-rheumatoid-arthritis
#3
Zhi-Tao Feng, Juan Xu, Guo-Chao He, San-Jin Cai, Juan Li, Zhi-Gang Mei
To assess the efficacy and safety of the combination of total glucoside of peony (TGP) and methotrexate (MTX) for the treatment of rheumatoid arthritis (RA). Randomized controlled trial (RCT) data on the traditional Chinese active component TGP combined with MTX vs. MTX alone for the treatment of RA was collected by searching the Pubmed, Embase, Cochrane Library, CNKI, VIP Journals database, and Wanfang database up to February 2017. Study selection, data extraction, data synthesis, and data analyses were performed according to the Cochrane standards...
July 27, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28748512/cross-cultural-adaptation-and-validation-of-the-chinese-version-of-the-health-assessment-questionnaire-for-the-spondyloarthropathies-haq-s
#4
DeLin Liu, Chen Zhang, Chen Wang, Jiao Liu, DaHe Li, Jia Li, Weidong Xu
The Health Assessment Questionnaire for Spondyloarthropathies (HAQ-S) is a commonly used questionnaire to evaluate function and health status of patients with ankylosing spondylitis (AS). The objective of this study was to cross-culturally adapt the HAQ-S into Chinese and then to evaluate its reliability and validity. The Chinese version of the HAQ-S was obtained with a five-step procedure of translation and cross-cultural adaptation. All invited patients met the New York criteria for AS, and a total of 103 patients finally participated in this study...
July 27, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28747790/involvement-of-the-leptin-adiponectin-axis-in-inflammation-and-oxidative-stress-in-the-metabolic-syndrome
#5
Gema Frühbeck, Victoria Catalán, Amaia Rodríguez, Beatriz Ramírez, Sara Becerril, Javier Salvador, Piero Portincasa, Inmaculada Colina, Javier Gómez-Ambrosi
The aim of the present work was to study whether the leptin-adiponectin axis may have a pathophysiological role in the increased systemic inflammation and oxidative stress observed in patients with the metabolic syndrome (MS). Leptin, adiponectin, and markers of inflammation and oxidative stress were measured in a sample of 140 Caucasian subjects (74 males/66 females), aged 28-82 years, 60 with and 80 without the MS. Total concentrations of adiponectin as well as its multimeric forms HMW, MMW and LMW were significantly lower in individuals with the MS...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28747607/safety-and-effectiveness-of-certolizumab-pegol-in-patients-with-rheumatoid-arthritis-interim-analysis-of-post-marketing-surveillance
#6
Hideto Kameda, Keiichiro Nishida, Toshihiro Nannki, Akira Watanabe, Yukiya Oshima, Shigaki Momohara
  Objective: To evaluate the safety and effectiveness of certolizumab pegol (CZP) in a real-world setting among Japanese patients with rheumatoid arthritis. METHODS: Post-marketing surveillance data from 2,579 patients treated with CZP were analyzed. Adverse events (AEs) observed during the 24-week CZP treatment period were recorded. Disease activity was evaluated using DAS28-ESR and DAS28-CRP at baseline, Week 12, Week 24, or at withdrawal. RESULTS: The total period of exposure to CZP was 1313...
2017: Nihon Rinshō Men'eki Gakkai Kaishi, Japanese Journal of Clinical Immunology
https://www.readbyqxmd.com/read/28747155/indole-3-acetic-acid-indoxyl-sulfate-and-paracresyl-sulfate-do-not-influence-anemia-parameters-in-hemodialysis-patients
#7
Stanislas Bataille, Marion Pelletier, Marion Sallée, Yvon Berland, Nathalie McKay, Ariane Duval, Stéphanie Gentile, Yosra Mouelhi, Philippe Brunet, Stéphane Burtey
BACKGROUND: The main reason for anemia in renal failure patients is the insufficient erythropoietin production by the kidneys. Beside erythropoietin deficiency, in vitro studies have incriminated uremic toxins in the pathophysiology of anemia but clinical data are sparse. In order to assess if indole 3-acetic acid (IAA), indoxyl sulfate (IS), and paracresyl sulfate (PCS) -three protein bound uremic toxins- are clinically implicated in end-stage renal disease anemia we studied the correlation between IAA, IS and PCS plasmatic concentrations with hemoglobin and Erythropoietin Stimulating Agents (ESA) use in hemodialysis patients...
July 26, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28746320/c-reactive-protein-in-periodontitis-and-its-comparison-with-body-mass-index-and-smoking-behaviour
#8
S Gupta, S Pradhan, S Kc, S Shakya, M Giri
INTRODUCTION: Chronic periodontitis is an infectious disease resulting in inflammation within the supporting tissues of the teeth, progressive attachment loss, and bone loss. In addition to declining oral health, there is always low grade infection present in periodontitis. Studies show increased levels of systemic biomarkers in periodontal disease such as CRP, which is considered a key-marker of CVD. Research has also shown positive association between BMI and smoking with periodontitis and CRP...
April 2017: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/28746227/diagnostic-yield-of-stool-culture-and-predictive-factors-for-positive-culture-in-patients-with-diarrheal-illness
#9
Jae Young Lee, Sun Young Cho, Hannah Sun Hae Hwang, Ja Young Ryu, Jongjin Lee, In Do Song, Beom Jin Kim, Jeong Wook Kim, Sae Kyung Chang, Chang Hwan Choi
We aimed to investigate the diagnostic yield of stool cultures and identify predictive factors for positive cultures in patients with diarrheal illness.A total of 13,327 patients who underwent stool cultures due to diarrheal illness were reviewed. Stool cultures were performed for enteric pathogens, including Salmonella, Shigella, Vibrio, Klebsiella oxytoca, and Yersinia. The culture-positive group was compared with the culture-negative group who were randomly selected from culture negative patients.A total of 196 patients (1...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28746196/retrospective-review-of-laparoscopic-versus-open-surgery-in-the-treatment-of-appendiceal-abscess-in-pediatric-patients-laparoscopic-versus-open-surgery-for-appendiceal-abscess
#10
Ping Li, Yan Han, Yang Yang, Hongjie Guo, Fabao Hao, Yan Tang, Chunbao Guo
Laparoscopic appendectomy (LA) has become well accepted, but the role of LA for appendicitis upon presentation with an abscess remains undefined. This study was to assess the postoperative recovery and complications following LA in pediatric patients with appendiceal abscess in comparison with open appendectomy (OA).We conducted a retrospective review of patients presented with appendiceal abscess between 2005 and 2016. Propensity score matching (PSM) was conducted to adjust for any potential selection bias for the surgical approaches...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28746193/comparing-common-doses-double-dose-vs-usual-dose-of-atorvastatin-for-preventing-contrast-induced-acute-kidney-injury-and-mortality-after-coronary-angiography
#11
Wei-Jie Bei, Shi-Qun Chen, Hua-Long Li, Deng-Xuan Wu, Chongyang Duan, Ping-Yan Chen, Ji-Yan Chen, Ning Tan, Nian-Jin Xie, Yong Liu
High-dose atorvastatin pretreatment was proved reducing the risk of contrast-induced acute kidney injury (CI-AKI), especially in patients with high C-reactive protein (CRP) levels. We evaluated the effects of common atorvastatin doses (double vs usual) on the risk of CI-AKI and mortality.We recorded outcomes from 1319 patients who were administered periprocedural common doses of atorvastatin. The risks of CI-AKI and mortality between double-dose (40 mg/d) and usual-dose atorvastatin (20 mg/d) were compared using multivariable regression models in all patients or CRP tertile subgroups...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28746189/early-prediction-of-infected-pancreatic-necrosis-secondary-to-necrotizing-pancreatitis
#12
Hong-Ze Chen, Liang Ji, Le Li, Gang Wang, Xue-Wei Bai, Chun-Dong Cheng, Bei Sun
To assess the association between the clinical parameters within 48 hours of admission and the occurrence of infected pancreatic necrosis (IPN) during the late phase of necrotizing pancreatitis (NP).All patients were divided into 2 groups, the IPN and non-IPN groups. The clinical data were retrospectively analyzed. Univariate and multivariate logistic regression analyses were performed to evaluate the relationship between clinical parameters and IPN secondary to NP. The performance of each independent variable was plotted by the receiver-operating characteristic (ROC) curve...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28745786/impacts-of-serum-p-selectin-on-blood-pressure-control-after-pci-in-patients-with-coronary-heart-disease-complicated-with-hypertension
#13
F-F Yang, F Peng, Y-B Xing, M Yuan, X-C Ma, G Li, H-Y Guo
OBJECTIVE: We analyzed the impact of potent anti-hypertension or anti-thrombotic therapy after PCI in patients with coronary heart disease complicated with hypertension, whilst to reflect the prognosis by testing P-selectin. PATIENTS AND METHODS: A total of 177 patients with coronary heart disease (CHD) complicated with hypertension was continuously enrolled in this study and randomly divided into traditional anti-hypertension group (group A: 130/80 mm Hg ≤ BP ≤ 140/90 mm Hg; anti-hypertensive drugs: β blockers and angiotensin converting enzyme inhibitor, n=84) and potent anti-hypertension group (group B: BP <130/80 mm Hg; dosage and frequency in group B > group A, n=93)...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28745693/-efficiency-of-different-celecoxib-regimens-in-patients-with-active-axial-spondyloarthritis-results-of-the-4-week-pilot-open-label-comparative-single-center-study-aim
#14
I Z Gaydukova, К A Gamayunova, K D Dorogoykina, A P Rebrov
AIM: To compare the efficiency and safety of two celecoxib regimens in the short-term treatment of patients with axial spondyloarthritis (axSpA). SUBJECTS AND METHODS: Examinations were made in 40 patients with axSpA (the 2009 ASAS criteria; age, 38.5±12.1 years; 29 (72.5%) men; axSpA duration, 6.67±5.8 years; BASDAI ≥4.0), who were randomly divided into two groups: 1) 20 patients who received celecoxib 400 mg/day for 30 days; 2) 20 patients who took celecoxib 600 mg/day for 7 days, then the drug was continued at a dose of 200 mg/day for 1 month...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28745108/comparison-of-drug-survival-and-clinical-outcome-in-patients-with-ankylosing-spondylitis-treated-with-etanercept-or-adalimumab
#15
J Ruwaard, M J l'Ami, A F Marsman, E L Kneepkens, J C van Denderen, I E van der Horst-Bruinsma, M T Nurmohamed, G Wolbink
OBJECTIVE: To compare rates of drug survival and clinical response during 2 years of follow-up in ankylosing spondylitis (AS) patients treated with etanercept or adalimumab in routine care. METHOD: Biological-naïve consecutive AS patients treated with etanercept (n = 163) or adalimumab (n = 82) were followed. Treatment discontinuation was due to inefficacy, adverse events, loss to follow-up, planning a pregnancy, or uveitis. Disease activity was assessed by the Ankylosing Spondylitis Disease Activity Score using C-reactive protein (ASDAS-CRP)...
July 26, 2017: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/28744697/prospective-validation-of-neutrophil-to-lymphocyte-ratio-as-a-diagnostic-and-management-adjunct-in-acute-appendicitis
#16
A Khan, M Riaz, Michael E Kelly, W Khan, R Waldron, K Barry, I Z Khan
BACKGROUND: No optimal biomarker exists that accurately diagnoses appendicitis or predicts severity, estimates post-operative complications or total length of hospital stay (LOS). AIM: To prospectively validate the utility of neutrophil-to-lymphocyte (NLR) ratio in predicting the severity of appendicitis, LOS, and 30-day complication rates. METHODS: Patients who were admitted with a provisional diagnosis of acute appendicitis over a period of 18 months (Oct 2014-April 2016) were included...
July 25, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28744116/tumor-necrosis-factor-receptor-2-as-a-possible-marker-of-copd-in-smokers-and-ex-smokers
#17
Laura Miranda de Oliveira Caram, R Ferrari, D L Nogueira, Mrm Oliveira, F V Francisqueti, S E Tanni, C R Corrêa, I Godoy
INTRODUCTION: Oxidative stress and systemic inflammation are higher in smokers and patients with COPD; however, markers that may help differentiate between smokers and patients with COPD have not yet been identified. We hypothesized that tumor necrosis factor-alpha receptor (TNFR) and soluble form of the receptor for advanced glycation end products (sRAGE) can be indicators of COPD in asymptomatic patients. PATIENTS AND METHODS: We evaluated 32 smokers (smoking history >10 pack-years), 32 patients with mild/moderate COPD (smokers and ex-smokers), and 32 never smokers...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28743332/-clinical-significance-of-early-immunological-paralysis-in-patients-with-severe-h1n1-influenza-a
#18
Yongbing Qian, Hui Xie, Rui Tian, Jian Lu, Wei Jin, Ruilan Wang
OBJECTIVE: To analysis the immunological characteristics of patients with severe H1N1 influenza A, and to provide theoretical basis for predicting the prognosis of the disease. METHODS: A retrospective analysis was conducted. The clinical data of 15 patients diagnosed with severe H1N1 influenza A and admitted to Shanghai General Hospital of Nanjing Medical University from October 2015 to December 2016 were collected. All the patients were divided into survival and death groups according to 28-day survival...
July 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28741974/sarcopenia-and-physical-function-are-associated-with-inflammation-and-arteriosclerosis-in-community-dwelling-people-the-yakumo-study
#19
Tetsuro Hida, Shiro Imagama, Kei Ando, Kazuyoshi Kobayashi, Akio Muramoto, Kenyu Ito, Yoshimoto Ishikawa, Mikito Tsushima, Yoshihiro Nishida, Naoki Ishiguro, Yukiharu Hasegawa
OBJECTIVES: Sarcopenia reduces physical function, while chronic inflammation causes arteriosclerosis and decreases skeletal muscle. We conducted a cross-sectional study to elucidate the associations among sarcopenia, physical function, arteriosclerosis, and inflammation in community-dwelling people. METHODS: We recruited 335 participants in an annual health checkup. We diagnosed sarcopenia based on appendicular skeletal muscle mass index (aSMI) assessed by bioelectrical impedance analysis...
July 25, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28741078/-analysis-of-2000-surgically-treated-proximal-femoral-fractures-multiple-variables-influence-mortality
#20
Franz Müller, Michael Galler, Tanja Kottmann, Michael Zellner, Christian Bäuml, Bernd Füchtmeier
BACKGROUND: Due to demographic change, more proximal femoral fractures can be expected in the future. However, accurate growth rates as well as follow-up research extending more than 1 year postsurgery are still lacking. MATERIALS AND METHODS: First, we defined inclusion and exclusion criteria for the retrospective cohort study. Based on these, we collected all surgical interventions conducted between 1 January 2006 and 31 December 2015. For a total of 2000 consecutive procedures, we retrieved and analysed a total of 12 variables influencing mortality...
July 24, 2017: Der Unfallchirurg
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