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https://www.readbyqxmd.com/read/28535535/inflammation-is-an-important-covariate-for-the-crosstalk-of-sleep-and-the-hpa-axis-in-rheumatoid-arthritis
#1
Rainer H Straub, Jaqueline Detert, René Dziurla, Ingo Fietze, Peter-Andreas Loeschmann, Gerd R Burmester, Frank Buttgereit
Rheumatoid arthritis (RA) patients have sleep problems, and inflammation influences sleep. We demonstrated that sleep quality improves during intensified treatment with methotrexate (MTX) or etanercept (ETA). Since the hypothalamic-pituitary-adrenal (HPA) axis is involved in sleep regulation, this study investigated the interrelation between sleep parameters, inflammation as objectified by C-reactive protein (CRP), and serum cortisol and adrenocorticotropic hormone (ACTH) levels. Thirty-one eligible patients (disease activity score, DAS28CRP ≥3...
May 24, 2017: Neuroimmunomodulation
https://www.readbyqxmd.com/read/28535403/the-predictive-effect-of-inflammatory-markers-and-lipid-accumulation-product-index-on-clinical-symptoms-associated-with-polycystic-ovary-syndrome-in-nonobese-adolescents-and-younger-aged-women
#2
Esra Nur Tola, Serenat Eris Yalcin, Nadiye Dugan
OBJECTIVE(S): The aim of our study is to analyse the inflammatory markers and lipid accumulation product (LAP) index in nonobese adolescents and younger aged women with polycystic ovary syndrome (PCOS) compared with age and body mass index (BMI)-matched healthy controls and to determine whether the investigated parameters are potential markers for the etiopathogenesis of PCOS. We also aim to determine whether these inflammatory markers are predictive for developing some clinical implications, such as cardiovascular disease (CVD) and insulin resistance (IR), associated with PCOS...
May 15, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28534431/ameliorating-effect-of-anti-alzheimer-s-drugs-on-the-bidirectional-association-between-type-2-diabetes-mellitus-and-alzheimer-s-disease
#3
Amira S Ahmed, Rehab M Elgharabawy, Amal H Al-Najjar
Mild to severe forms of nervous system damage were exhibited by approximately 60-70% of diabetics. It is important to understand the association between type 2 diabetes mellitus and Alzheimer's disease. The aim of the present work is to understand the bidirectional association between type 2 diabetes and Alzheimer's disease pathogenesis, that was monitored by glycaemic status, lipid profile, amyloid beta 40 and 42 (Aβ40 and Aβ42), C-reactive protein, total creatine kinase, total lactate dehydrogenase, D-dimer and magnesium measurements, to assess the association between theses biochemical markers and each other, to estimate the possibility of utilizing the amyloid beta as biochemical marker of T2D in Alzheimer's patients, and to evaluate the effect of piracetam and memantine drugs on diabetes mellitus...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28534329/-predictive-value-of-procalcitonin-in-postoperative-intra-abdominal-infections-after-definitive-operation-of-intestinal-fistulae
#4
Huajian Ren, Gefei Wang, Guosheng Gu, Qiongyuan Hu, Guanwei Li, Zhiwu Hong, Xiuwen Wu, Jianan Ren
OBJECTIVE: To investigate the predictive value of procalcitonin(PCT) in postoperative intra-abdominal infections (IAI) after definitive operation of intestinal fistulae(IF). METHODS: With the exclusion of emergence operation, preoperative clinical infection, preoperative renal or hepatic dysfunction, and age less than 18 years, a total of 356 consecutive patients who underwent elective digestive tract reconstruction of intestinal fistulae from February 2012 to December 2015 at Intestinal Fistula Center of Jinling Hospital were prospectively enrolled in the study...
May 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28534297/single-frequency-impedance-analysis-on-reduced-graphene-oxide-screen-printed-electrode-for-biomolecular-detection
#5
Rajesh, Shobhita Singal, Ravinder K Kotnala
A biofunctionalized reduced graphene oxide (rGO)-modified screen-printed carbon electrode (SPCE) was constructed as an immunosensor for C-reactive protein (CRP) detection, a biomarker released in early stage acute myocardial infarction. A different approach of single frequency analysis (SFA) study was utilized for the biomolecular sensing, by monitoring the response in phase angle changes obtained at an optimized frequency resulting from antigen-antibody interactions. A set of measurements were carried out to optimize a frequency where a maximum change in phase angle was observed, and in this case, we found it at around 10 Hz...
May 22, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28534129/insomnia-muscular-cramps-and-pruritus-have-low-intensity-in-hemodialysis-patients-with-good-dialysis-efficiency-low-inflammation-and-arteriovenous-fistula
#6
Olga Hilda Orasan, Aniela Pop Saplontai, Angela Cozma, Simona Racasan, Ina Maria Kacso, Crina Claudia Rusu, Diana Moldovan, Dacian Tirinescu, Alina Potra, Ioan Mihai Patiu, Remus Aurel Orasan
INTRODUCTION: Insomnia, muscular cramps, pruritus and postdialysis recovery time (RT) are quality-of-life parameters that affect hemodialysis (HD) patients physically and mentally. METHODS: We included 171 end-stage renal disease patients: 115 on high-flux HD and 56 on online hemodiafiltration (HDF). Patients were asked "How long does it take you to recover from a dialysis session?" and they evaluated intensity (absent, mild, medium and severe) of insomnia, muscular cramps and pruritus in the past 4 weeks...
May 22, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28534128/cathepsin-l-activity-correlates-with-proteinuria-in-chronic-kidney-disease-in-humans
#7
Yu Cao, Xing Liu, Ying Li, Yao Lu, Hua Zhong, Weihong Jiang, Alex F Chen, Timothy R Billiar, Hong Yuan, Jingjing Cai
BACKGROUND: The presence and severity of proteinuria is considered an important prognostic marker in patients with chronic kidney disease (CKD) and is associated with mortality and morbidity. Cathepsin L is highly expressed in the foot processes of podocytes in the kidney, which serves as an ultrafiltration barrier. Cathepsin L is also up-regulated in the setting of inflammation as a feature of CKD. Therefore, we postulated that proteinuria severity in CKD patients might correlate with increased serum levels of cathepsin L...
May 22, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28534075/comparison-between-different-disease-activity-scores-in-rheumatoid-arthritis-an-egyptian-multicenter-study
#8
M Eissa, A El Shafey, M Hammad
The aim of our work was to assess the performance of different Disease Activity Score (DAS) other than DAS-ESR in daily clinical practice in our Egyptian outpatient clinics and also to evaluate the accuracy of European League Against Rheumatism Classification (EULAR) proposed cutoffs for these scores to stratify Egyptian patients into different categories of disease activity. This study is a cross-sectional Egyptian multicenter study. It included 130 rheumatoid arthritis (RA) patients who visited our Rheumatology and Rehabilitation outpatient and inpatient clinics; 80 patients from Cairo University Hospitals and 50 patients from Zagazig University Hospitals...
May 22, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28533981/effects-of-knee-sleeves-on-coordination-of-lower-limb-segments-in-healthy-adults-during-level-walking-and-one-leg-hopping
#9
Chang-Yong Ko, Yunhee Chang, Bora Jeong, Sungjae Kang, Jeicheong Ryu, Gyoosuk Kim
The evaluation of multisegment coordination is important in gaining a better understanding of the gait and physical activities in humans. Therefore, this study aims to verify whether the use of knee sleeves affects the coordination of lower-limb segments during level walking and one-leg hopping. Eleven healthy male adults participated in this study. They were asked to walk 10 m on a level ground and perform one-leg hops with and without a knee sleeve. The segment angles and the response velocities of the thigh, shank, and foot were measured and calculated by using a motion analysis system...
2017: PeerJ
https://www.readbyqxmd.com/read/28533443/fhr-1-binds-to-c-reactive-protein-and-enhances-rather-than-inhibits-complement-activation
#10
Ádám I Csincsi, Zsóka Szabó, Zsófia Bánlaki, Barbara Uzonyi, Marcell Cserhalmi, Éva Kárpáti, Agustín Tortajada, Joseph J E Caesar, Zoltán Prohászka, T Sakari Jokiranta, Susan M Lea, Santiago Rodríguez de Córdoba, Mihály Józsi
Factor H-related protein (FHR) 1 is one of the five human FHRs that share sequence and structural homology with the alternative pathway complement inhibitor FH. Genetic studies on disease associations and functional analyses indicate that FHR-1 enhances complement activation by competitive inhibition of FH binding to some surfaces and immune proteins. We have recently shown that FHR-1 binds to pentraxin 3. In this study, our aim was to investigate whether FHR-1 binds to another pentraxin, C-reactive protein (CRP), analyze the functional relevance of this interaction, and study the role of FHR-1 in complement activation and regulation...
May 22, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28532132/distributions-of-high-sensitivity-c-reactive-protein-total-cholesterol-hdl-ratio-and-10-year-cardiovascular-risk-national-population-based-study
#11
Alipasha Meysamie, Saeed Ghodsi, Reza Ghalehtaki, Alireza Esteghamati, Fereshteh Asgari, Mohammad Mehdi Gouya
The present study aimed to evaluate the distributions of High-Sensitivity C-reactive protein, TC-HDL ratio and 10-year risk of cardiovascular diseases among Iranian adult population. We conducted a cross-sectional study on a total of 2125 adults aged 25 to 65. Data of the Third National Surveillance of Risk Factors of Non-Communicable Diseases (SuRFNCD-2007) was used. Anthropometric indices, blood pressure and biochemical measurements had been obtained. Ten-year risk of cardiovascular events was also calculated using different models...
April 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28531785/the-relationship-between-malnutrition-risk-and-clinical-outcomes-in-a-cohort-of-frail-older-hospital-patients
#12
Adrian Slee, Deborah Birch, David Stokoe
BACKGROUND & AIMS: Malnutrition has an adverse effect on clinical outcomes and frail older people may be at greater risk of malnutrition. The purpose and aims of this study was to investigate the relationship between markers of malnutrition risk and clinical outcomes in a cohort of frail older hospital patients. METHODS: 78 frail older hospital patients had the following measurements recorded; length of stay (LOS), time to medical fitness for discharge (TMFFD), body mass index (BMI), malnutrition universal screening tool (MUST) and mini-nutritional assessment short-form (MNA-SF) scores, blood urea, C-reactive protein (CRP), albumin, CRP-albumin ratio; and bioelectrical impedance assessment (BIA) measurements (n = 66)...
October 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28531784/gut-microbiota-mediated-benefits-of-barley-kernel-products-on-metabolism-gut-hormones-and-inflammatory-markers-as-affected-by-co-ingestion-of-commercially-available-probiotics-a-randomized-controlled-study-in-healthy-subjects
#13
Anne Nilsson, Elin Johansson-Boll, Jonna Sandberg, Inger Björck
BACKGROUND AND AIMS: Barley kernel based products have been shown to induce benefits on blood glucose regulation, cardio-metabolic risk markers and appetite regulating hormones in a time perspective of 11-16 h after intake. The mechanisms have been assigned to gut fermentation of indigestible carbohydrates. The purpose of the present study was to evaluate if the modulatory effects of barley on markers of metabolic- and appetite regulation are affected by a dietary background including a mixture of commercially available probiotics...
October 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28531772/diet-induced-weight-loss-and-markers-of-endothelial-dysfunction-and-inflammation-in-treated-patients-with-type-2-diabetes
#14
K A Berk, T P Oudshoorn, A J M Verhoeven, M T Mulder, A J M Roks, W A Dik, R Timman, E J G Sijbrands
BACKGROUND & AIMS: Overweight and obesity increase cardiovascular mortality in patients with type 2 diabetes (T2D). In a recent trial, however, diet-induced weight loss did not reduce the cardiovascular risk of patients with T2D, possibly due to the parallel intensive medical treatment. We investigated the effect of diet-induced weight loss on cardiovascular risk factors in overweight and obese patients with T2D, and whether this effect was influenced by the use of statins, ACE inhibitors, metformin and duration of T2D...
October 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28531394/predictive-factors-of-early-mortality-after-percutaneous-endoscopic-gastrostomy-placement-the-importance-of-c-reactive-protein
#15
Mara Barbosa, Joana Magalhaes, Carla Marinho, Jose Cotter
INTRODUCTION AND AIMS: Percutaneous endoscopic gastrostomy (PEG) is considered one of the preferred routes for long-term enteral feeding. However, early mortality after PEG placement is high. We aimed at analyzing overall and early mortality in patients who underwent PEG insertion and at identifying risk factors of increased mortality after the procedure. METHODS: Retrospective study which included patients who had a PEG insertion at our department between May 2007 and January 2013...
August 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28531173/a-scoring-system-to-effectively-evaluate-central-nervous-system-tuberculosis-in-patients-with-military-tuberculosis
#16
Yongjiu Xiao, Shuqing Yu, Qingliang Xue, Shan Lang, Junping Sun, Dan Feng, Jianxin Wang
There is currently no convenient way to effectively evaluate whether a miliary tuberculosis patient is complicated with central nervous system (CNS) tuberculosis. We aimed to find such a way by analyzing the clinical data of these patients. Fifty patients with confirmed miliary tuberculosis and 31 patients with confirmed miliary tuberculosis complicated with CNS tuberculosis from 2010 to 2014 were selected. Their general conditions, clinical features and laboratory tests were analyzed. Factors that were significantly different between them were chosen to performed multivariate and univariate logistic regression analyses, and factors with significant P values were used to establish a scoring system...
2017: PloS One
https://www.readbyqxmd.com/read/28530771/macrophage-migration-inhibitory-factor-levels-correlate-with-an-infection-in-trauma-patients
#17
Young Duck Cho, Sung Hyuk Choi, Jung Youn Kim, Sung Jun Park, Young Hoon Yoon, Han Jin Cho, Ji Won Yeom
BACKGROUND: The role of migration inhibitory factor (MIF) is best understood in septic shock and septic disease; however, the role of MIF in a secondary infection after trauma has not yet been completely studied. This study aimed to evaluate the role of MIF in trauma patients. METHODS: The patients in the study population were divided into two groups according to the results of their MIF levels. The initial MIF levels, trauma mechanism, revised trauma score, survival rate, length of stay (LOS) in the intensive care unit (ICU), level of leukocytes, and level of C-reactive protein (CRP) were compared between the groups...
May 2017: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/28529744/prognostic-effect-of-serum-c-reactive-protein-kinetics-on-advanced-renal-cell-carcinoma-treated-with-sunitinib
#18
Tetsuo Fujita, Ken-Ichi Tabata, Daisuke Ishii, Kazumasa Matsumoto, Kazunari Yoshida, Masatsugu Iwamura
C-reactive protein (CRP) is an independent prognostic factor for renal cell carcinoma (RCC). The aim of the present study was to investigate the prognostic effect of pretreatment serum CRP level and CRP kinetics on patients with advanced RCC treated with sunitinib. A total of 56 consecutive patients with advanced RCC treated with sunitinib between December, 2008 and December, 2012 were enrolled in the present study. The patients were retrospectively divided into 3 cohorts according to pretreatment serum CRP level and CRP kinetics: i) Normal CRP cohort (pretreatment CRP ≤0...
May 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28529684/c-reactive-protein-and-radiographic-findings-of-lower-respiratory-tract-infection-in-infants
#19
Maria Twomey, Hannah Fleming, Fiachra Moloney, Kevin P Murphy, Lee Crush, Siobhan B O'Neill, Oisin Flanagan, Karl James, Conor Bogue, Owen J O'Connor, Michael M Maher
AIM: To evaluate the association between C-reactive protein (CRP) and radiological evidence of lower respiratory tract infection (LRTI) in infants. METHODS: All patients aged less than 4 years who presented with suspected lower respiratory tract infection, who received a peri-presentation chest radiograph and CRP blood measurement over an 18-mo period were included in the study. Age, gender, source of referral, CRP, white cell count, neutrophil count along with the patients' symptoms and radiologist's report were recorded...
April 28, 2017: World Journal of Radiology
https://www.readbyqxmd.com/read/28529615/a-novel-blood-tool-of-cancer-prognosis-in-esophageal-squamous-cell-carcinoma-the-fibrinogen-albumin-ratio
#20
Zihui Tan, Man Zhang, Qiang Han, Jing Wen, Kongjia Luo, Peng Lin, Lanjun Zhang, Hong Yang, Jianhua Fu
Background: Coagulation and nutrition play important roles in cancer progression. We aim to investigate the impact of the fibrinogen/albumin ratio(FAR) in esophageal squamous cell carcinoma (ESCC) patients. Methods: We retrospectively analyzed 1135 patients with radical esophagectomy for ESCC from January 2008 to December 2010 in our center. X-tile software was used to determine the optimal cutoff levels for these biomarkers. Results: The optimal cutoff value was 0.08 for the FAR by the X-tile software. The FAR was statistically significantly associated with age(p=0...
2017: Journal of Cancer
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