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https://www.readbyqxmd.com/read/28087832/comparison-of-cardiovascular-risk-algorithms-in-patients-with-vs-without-rheumatoid-arthritis-and-the-role-of-c-reactive-protein-in-predicting-cardiovascular-outcomes-in-rheumatoid-arthritis
#1
Evo Alemao, Hélène Cawston, François Bourhis, Maiwenn Al, Maureen Rutten-van Molken, Katherine P Liao, Daniel H Solomon
OBJECTIVES: The aims were to compare the performance of cardiovascular risk calculators, Framingham Risk Score (FRS) and QRISK2, in RA and matched non-RA patients and to evaluate whether their performance could be enhanced by the addition of CRP. METHODS: We conducted a retrospective analysis, using a clinical practice data set linked to Hospital Episode Statistics (HES) data from the UK. Patients presenting with at least one RA diagnosis code and no prior cardiovascular events were matched to non-RA patients using disease risk scores...
January 12, 2017: Rheumatology
https://www.readbyqxmd.com/read/28086896/fast-track-surgery-versus-conventional-perioperative-management-of-lung-cancer-associated-pneumonectomy-a-randomized-controlled-clinical-trial
#2
Qing Dong, Kai Zhang, Shouqiang Cao, Jian Cui
BACKGROUND: The aim of this study is to investigate the effects of fast-track surgery (FTS) on postoperative recovery, hospital stay, total medical costs, and the complications of pneumonectomy in patients with non-small cell lung cancer (NSCLC). METHODS: Studies were performed between June 2012 and March 2014 in 17 patients received FTS and 18 patients given conventional management (control) after pneumonectomy in the Department of Thoracic Surgery, the Fourth Affiliated Hospital of Harbin Medical University...
January 13, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28086838/clinical-characteristics-of-genital-chlamydia-infection-in-pelvic-inflammatory-disease
#3
Sung Taek Park, Suk Woo Lee, Min Jeong Kim, Young Mo Kang, Hye Min Moon, Chae Chun Rhim
BACKGROUND: Chlamydia infection in acute pelvic inflammatory disease (PID) is associated with serious complications including ectopic pregnancy, tubal infertility, Fitz-Hugh-Curtis syndrome and tubo-ovarian abscess (TOA). This study compared clinical and laboratory data between PID with and without chlamydia infection. METHODS: The medical records of 497 women who were admitted with PID between 2002 and 2011 were reviewed. The patients were divided into two groups (PID with and without chlamydia infection), which were compared in terms of the patients' characteristics, clinical presentation, and laboratory findings, including inflammatory markers...
January 13, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28086784/health-related-quality-of-life-assessment-in-acute-coronary-syndrome-patients-the-effectiveness-of-early-phase-i-cardiac-rehabilitation
#4
Lawrence Anchah, Mohamed Azmi Hassali, Melissa Siaw Han Lim, Mohamed Izham Mohamed Ibrahim, Kui Hian Sim, Tiong Kiam Ong
BACKGROUND: Acute Coronary Syndrome (ACS) is one of the most burdensome cardiovascular diseases in terms of the cost of interventions. The Cardiac Rehabilitation Programme (CRP) is well-established in improving clinical outcomes but the assessment of actual clinical improvement is challenging, especially when considering pharmaceutical care (PC) values in phase I CRP during admission and upon discharge from hospital and phase II outpatient interventions. This study explores the impact of pharmacists' interventions in the early stages of CRP on humanistic outcomes and follow-up at a referral hospital in Malaysia...
January 13, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28081323/acute-exudative-tonsillitis-in-adults-the-use-of-the-centor-scoreand-some-laboratory-tests
#5
Yavuz Furuncuoğlu, Filiz Sağlam, Ahmet Kutluhan
BACKGROUND/AIM: The aim of our study was to determine the usefulness of the Centor score and some basic laboratory tests (complete blood count and C-reactive protein) for the differential diagnosis of exudative tonsillitis due to Group A β-hemolytic streptococcus (GABHS) or due to non-GABHS agents. MATERIALS AND METHODS: The data of clinical and laboratory characteristics of the patients diagnosed with exudative tonsillitis were collected and statistically compared between those having positive GABHS throat culture result and those who were negative for any bacterial agent...
December 20, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28080905/plasma-protein-electrophoresis-and-select-acute-phase-proteins-in-healthy-bonnethead-sharks-sphyrna-tiburo-under-managed-care
#6
Michael W Hyatt, Cara L Field, Tonya M Clauss, Kristopher L Arheart, Carolyn Cray
Preventative health care of elasmobranchs is an important but understudied field of aquatic veterinary medicine. Evaluation of inflammation through the acute phase response is a valuable tool in health assessments. To better assess the health of bonnethead sharks ( Sphyrna tiburo ) under managed care, normal reference intervals of protein electrophoresis (EPH) and the acute phase proteins, C-reactive protein (CRP) and haptoglobin (HP), were established. Blood was collected from wild caught, captive raised bonnethead sharks housed at public aquaria...
December 2016: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28079845/predictive-value-of-c-reactive-protein-and-clinically-relevant-baseline-variables-in-sarcoidosis
#7
Melissa J McDonnell, Mohammed I Saleem, Deidre Wall, J J Gilmartin, R M Rutherford, Anthony O'Regan
BACKGROUND: This study aims to examine the predictive and prognostic implications of C-reactive protein (CRP) and clinically relevant baseline variables in determining treatment indication and disease progression in a large clinical cohort of patients with stable sarcoidosis. METHODS: A retrospective observational study of 328 sarcoidosis patients attending a regional tertiary referral centre over a 26-year period was performed. Clinical, biochemical, radiological and physiological data were analysed according to a clinically relevant dichotomous cutpoint of CRP...
December 23, 2016: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
https://www.readbyqxmd.com/read/28079501/clinical-efficacy-of-oral-alendronate-in-ankylosing-spondylitis-a-randomised-placebo-controlled-trial
#8
Lucy Coates, Jonathan C Packham, Paul Creamer, Sarah Hailwood, Ashley S Bhalla, Kuntal Chakravarty, Diamuid Mulherin, Gordon Taylor, Derek L Mattey, Ashok K Bhalla
OBJECTIVES: A prospective, double blind, randomised, placebo controlled trial over 2 years was performed to test the efficacy of alendronate, an oral aminobisphosphonate, in improving symptoms and arrest disease progression in patients with mild to severe ankylosing spondylitis (AS). METHODS: 180 patients with AS were randomised to receive weekly alendronate 70 mg or placebo (1:1 randomisation). BAS-G was the primary outcome measure with Bath indices as secondary outcomes...
January 4, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28079172/25-oh-d-and-1-25-oh-d-vitamin-d-fails-to-predict-sepsis-and-mortality-in-a-prospective-cohort-study
#9
Franz Ratzinger, Helmuth Haslacher, Markus Stadlberger, Ralf L J Schmidt, Markus Obermüller, Klaus G Schmetterer, Thomas Perkmann, Athanasios Makristathis, Rodrig Marculescu, Heinz Burgmann
The clinical role of vitamin D in sepsis and mortality prediction is controversially discussed. Therefore, we conducted a prospective cohort study on standard care wards, including 461 patients with suspected sepsis fulfilling two or more SIRS criteria. On the first and third day after onset of SIRS symptoms levels of 25(OH)D, 1,25(OH)D and sepsis biomarkers were analysed for their predictive capacity for identifying infection, bacteraemia and an elevated mortality risk. Additionally, several SNPs associated with vitamin D metabolism were evaluated...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28078862/a-placebo-controlled-trial-of-a-proprietary-lipid-lowering-nutraceutical-supplement-in-the-management-of-dyslipidemia
#10
M Houston, R Rountree, J Lamb, S Phipps, S Meng, B Zhang
There is an ever growing emergence in the popularity of patient-driven care. As this health and wellness model grows, inquiries into diet, lifestyle, and supplemental approaches will continue to become a focal point for the healthcare consumer. Because of this, the aim of this study is to determine the tolerability, and overall effectiveness of a proprietary multi-ingredient lipid-lowering supplement in subjects with dyslipidemia. Forty participants were recruited for a single-center, double-blind randomized, placebocontrolled trial...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28078861/interleukin-6-and-interleukin-8-in-diagnosing-neonatal-septicemia
#11
Y Q Wu, J Shen, Q L Zhou, H W Zhao, L R Liu, X Liu
Neonatal septicemia (NS) is a common cause of death of newborn infants, hence early diagnosis and treatment are of the utmost importance. However, lack of specific clinical symptoms and late detection delay a correct diagnosis. It is therefore of great importance to establish auxiliary indexes for the early diagnosis of NS. To evaluate the value of interleukin (IL-6 and IL-8) in the diagnosis of NS, a prospective study was carried out. Seventy-five newborns who developed septicemia and received treatment in our hospital from January 2013 to December 2014 were selected as research subjects; also, 50 healthy newborns were set as a control group...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28077811/nutrition-status-predicts-severity-of-vascular-calcification-in-non-dialyzed-chronic-kidney-disease
#12
Kazuhiro Harada, Susumu Suzuki, Hideki Ishii, Kenshi Hirayama, Toshijiro Aoki, Yohei Shibata, Yosuke Negishi, Takuya Sumi, Kazuhiro Kawashima, Ayako Kunimura, Yosuke Tatami, Toshiki Kawamiya, Dai Yamamoto, Ryota Morimoto, Yoshinari Yasuda, Toyoaki Murohara
BACKGROUND: Vascular calcification is a major complication in chronic kidney disease (CKD) that increases the risk of adverse clinical outcomes. Geriatric nutritional risk index (GNRI) is a simple nutritional assessment tool that predicts poor prognosis in elderly subjects. The purpose of the present study was to evaluate the correlation between GNRI and severity of vascular calcification in non-dialyzed CKD patients.Methods and Results:We enrolled 323 asymptomatic CKD patients. To evaluate abdominal aortic calcification (AAC), we used aortic calcification index (ACI) determined on non-contrast computed tomography...
January 12, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28077136/increased-leptin-adiponectin-ratio-relates-to-low-normal-thyroid-function-in-metabolic-syndrome
#13
Lynnda J N van Tienhoven-Wind, Robin P F Dullaart
BACKGROUND: Low-normal thyroid function within the euthyroid range may contribute to increased atherosclerosis susceptibility. The leptin/adiponectin (L/A) ratio is associated with cardiovascular disease and reflects adipose tissue dysfunction. Relationships of the L/A ratio with low-normal thyroid function are unknown. METHODS: Relationships of thyroid stimulating hormone (TSH) and free thyroxine (free T4) with leptin, adiponectin and the L/A ratio in euthyroid subjects were documented in 67 fasting subjects with metabolic syndrome (Mets) and 86 euthyroid subjects without MetS (TSH and free T4 levels within the institutional reference range)...
January 11, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28076310/the-serum-concentrations-of-leptin-and-mcp-1-independently-predict-low-back-pain-duration
#14
Giuseppe Lippi, Concetta Dagostino, Ruggero Buonocore, Rosalia Aloe, Chiara Bonaguri, Guido Fanelli, Massimo Allegri
BACKGROUND: Low back pain (LBP) is a very frequent condition, affecting most people at some point throughout their life. This cross-sectional study was aimed to investigate a selected panel of cytokines and inflammatory biomarkers in patients with or without LBP. METHODS: The study population consisted of 104 patients diagnosed with LBP (52 non-persistent and 52 persistent) and 52 healthy subjects with no LBP. Blood samples were collected for assessment of adiponectin, leptin, monocyte chemoattractant protein-1 (MCP-1) and C reactive protein (CRP)...
January 11, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28074977/-association-of-c-reactive-protein-levels-with-metabolic-syndrome-in-adults-a-population-based-study
#15
Patricia Bustos, Bernardita Rosas, Pablo Román, Juan Villagrán, Hugo Amigo
BACKGROUND: Metabolic syndrome is highly prevalent among adults in Chile and represents a health risk. AIM: To determine the relationship between metabolic syndrome (MetS) and its components, with C reactive protein levels (CRP) as an inflammation marker. MATERIAL AND METHODS: The population studied consisted of 736 individuals born in a hospital from Valparaíso Region, aged between 32-38 years at the time of the study. MetS was identified according to the Adult Treatment Panel (ATP) III guidelines and inflammation was measured using ultra-sensitive CRP...
October 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/28073957/primary-inefficacy-of-tnf-inhibitors-in-patients-with-axial-spondyloarthritis-a-long-term-follow-up-of-25-patients
#16
Sandra Kossi, Sabrina Dadoun, Guillaume Geri, Aurore Hermet, Bruno Fautrel, Maxime Dougados, Laure Gossec
OBJECTIVES: Primary inefficacy of TNF inhibitors (TNFi) for axial spondyloarthritis (axSpA) is infrequent. The objective of this study was to assess the long-term evolution and final diagnosis of patients with primary inefficacy of TNFi for axSpA. METHODS: This was a systematic retrospective study of all patients receiving a TNFi for axSpA in one tertiary referral centre. Patients had axSpA confirmed by a rheumatologist and were started on a first course of TNFi according to usual practice...
January 9, 2017: Rheumatology
https://www.readbyqxmd.com/read/28073639/association-between-volume-and-glucose-metabolism-of-abdominal-adipose-tissue-in-healthy-population
#17
Hyun Woo Kwon, Sang Mi Lee, Jeong Won Lee, Jung-Eun Oh, Se-Whan Lee, Shin Young Kim
OBJECTIVE: We investigated the association of adipose tissue volume and metabolic activity with cardiometabolic risk factors. METHODS: 232 healthy subjects (43.23±4.09y) having (18)F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) results were included. Clinical information, anthropometry and laboratory results were obtained. Volume and metabolic activity of subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) was obtained from FDG PET/CT...
January 7, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28072726/no-further-gain-can-be-achieved-by-calculating-disease-activity-score-in-28-joints-with-high-sensitivity-assay-of-c-reactive-protein-because-of-high-intraindividual-variability-of-c-reactive-protein-a-cross-sectional-study-and-theoretical-consideration
#18
Inger M J Hansen, Amir Emamifar, Rikke A Andreasen, Steen Antonsen
Disease Activity Score in 28 joints (DAS28) is commonly used to evaluate disease activity of rheumatoid arthritis (RA) and is a guide to treatment decision.The aim of this study was to evaluate the impact of lower reporting limit for C-reactive protein (CRP), with respect to intraindividual biological variability, on the calculation of DAS28 and subsequent patient classification.This study consists of 2 sections: a theoretical consideration discussing the performance of CRP in calculating DAS28 taking intraindividual biological variation and lower reporting limit for CRP into account and a cross-sectional study of RA patients applying our theoretical results...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28070551/data-on-circulating-leukocyte-subpopulations-and-inflammatory-proteins-in-children-with-familial-hypercholesterolemia-and-healthy-children
#19
Jacob J Christensen, Liv Osnes, Bente Halvorsen, Kjetil Retterstøl, Martin P Bogsrud, Cecilie Wium, Arne Svilaas, Ingunn Narverud, Stine M Ulven, Pål Aukrust, Kirsten B Holven
The data in this relies on a previous publication: "Altered leukocyte distribution under hypercholesterolemia: a cross-sectional study in children with familial hypercholesterolemia" (Christensen et al. 2016) [1]. In the present paper, whole blood leukocyte distribution and plasma inflammatory proteins were measured for association with cholesterol concentration and CRP in children with familial hypercholesterolemia (FH) and healthy children.
February 2017: Data in Brief
https://www.readbyqxmd.com/read/28070203/a-pilot-observational-study-on-magnesium-and-calcium-imbalance-in-elderly-patients-with-acute-aortic-dissection
#20
E Vianello, E Dozio, A Barassi, G Sammarco, L Tacchini, M M Marrocco-Trischitta, S Trimarchi, M M Corsi Romanelli
BACKGROUND: Magnesium (Mg) and calcium (Ca) are the principal essential elements involved in endothelial cell homeostasis. Extracellular changes in the levels of either alter endothelial contraction and dilatation. Consequently Mg and Ca imbalance is associated with a high risk of endothelial dysfunction, the main process observed during acute aortic dissection (AAD); in this clinical condition, which mainly affects elderly men, smooth muscle cell alterations lead to intimal tears, creating a false new lumen in the media of the aorta...
2017: Immunity & Ageing: I & A
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