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https://www.readbyqxmd.com/read/29227259/hypothyroidism-a-special-comorbidity-factor-in-patients-with-osteoarthrosis-clinical-pathophysiological-and-prognostic-aspects
#1
L Voloshyna, О Doholich, I Sithinska
Objective - to study the features of the functional and morphological condition of the thyroid gland (TG) in patients with osteoarthrosis (OA), the incidence and forms of hypothyroidism and their effects on clinical manifestations, metabolic disorders and the results of the treatment of OA and comorbid processes. A complex examination involved 312 patients with OA aged 37-76 years. Methods used: anthropometric, clinical, ultrasonographic, biochemical, radioimmunological (levels of TSH, free thyroxine, antibodies to thyroid peroxidase)...
November 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29217163/cx3cr1-regulates-osteoarthrosis-chondrocyte-proliferation-and-apoptosis-via-wnt-%C3%AE-catenin-signaling
#2
You Sun, Feifei Wang, Xuehui Sun, Xiaoxue Wang, Lei Zhang, Yang Li
OBJECTIVE: The study was aimed to investigate the impact of CX3CR1 expression on the proliferation and apoptosis of osteoarthrosis (OA) chondrocytes through Wnt/ β-catenin pathway. METHODS: The expression levels of CX3CR1 and Wnt/β-catenin pathway-related genes mRNA and protein in OA chondrocytes were examined by qRT-PCR and western blot. MTT and flow cytometry (FCM) assays were employed to assess cell proliferation, cell cycle and apoptosis. XAV-939, a Wnt/β-catenin pathway inhibitor, was used to inhibit the pathway...
December 4, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29186097/-the-experience-of-the-using-tolperisone-in-a-complex-conservative-therapy-of-an-osteoarthrosis-of-a-hip-joint
#3
O A Kaplunov, K O Kaplunov, E U Nekrasov
AIM: The comparison of the efficiency of the standard scheme of a conservative medicinal therapy of an OA of a hip joint and the modified scheme (with the muscle relaxant of the central action - Tolperisone) was the research objective. MATERIAL AND METHODS: The prospective research of the complex conservative therapy of two pools of patients with initial stages of a coxarthrosis from 2014 for 2017 with the subject assessment articulary treatment components is conducted...
2017: Khirurgiia
https://www.readbyqxmd.com/read/29162237/inter-individual-gene-variants-associated-with-trabecular-bone-plasticity-a-step-forward-in-the-personal-genomics-of-degenerative-bone-disease
#4
Enrique Caso, Cristina C Sabiers, Daniel López-Guillén, Jaime Caso, Manuel Toledano, Raquel Osorio, Estrella Osorio, Carmen Lozano, Enrique Guerado
Continuing tissue destruction in osteoarthrosis is maintained by molecular pathways related to an unbalanced chondrocyte metabolism, the loss of reactive oxygen species (ROS) homeostasis, increase catabolism in a degraded matrix and the limited response to growth factors due to cell aging. Rare deleterious gene variants driving relevant molecular pathways may play a key role in the pathogenesis and genetic control of common diseases and may also influence the common gene variants observed in GWAS. We use molecular profiling technologies based on massive sequencing of genes to interrogate clinical samples for a variety of molecules involved in the pathogenesis pathways of OA and also to derive new insights for drug targeting discovery at an early stage of the disease...
November 2017: Injury
https://www.readbyqxmd.com/read/29155310/legg-calv%C3%A3-perthes-disease
#5
REVIEW
J Leroux, S Abu Amara, J Lechevallier
Current knowledge of the causes and risk factors of Legg-Calvé-Perthesdisease (LCPD) does not allow effective preventive strategies. The outcome in adulthood is usually good. Hip osteoarthritis rarely develops before 50 years of age. The risk of osteoarthrosis depends chiefly on the final degree of joint incongruence. Age at onset and the lateral pillar classification are the two main outcome predictors and serve to guide the surgical indications based on the studies by Herring's group. Non-operative treatment is not effective...
November 16, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29115378/synovial-fluid%C3%A2-derived-synovial-fragments-represent-an-improved-source-of-synovial-mesenchymal-stem-cells-in-the-temporomandibular-joint
#6
Yu Yao, Zheng-Yu Li, Hong Zhang, You-Hua Zheng, Li-Xiang Mai, Wen-Jing Liu, Zhi-Guang Zhang, Yang-Peng Sun
Surgery-obtained synovium specimens (SSSs) can provide a source of synovial mesenchymal stem cells (SMSCs) for experimental studies. However, these specimens contain diverse tissues, including the intima and subintima; therefore, these SMSCs are not entirely derived from the intima and their cell source is heterogeneous. The present study isolated synovial fragments (SFs) from synovial fluid dilutions extracted from patients with temporomandibular joint (TMJ) osteoarthrosis. Unlike SSSs, SFs, which are membranous and translucent, consist of only several cell layers, indicating the presence of only the intima...
October 25, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29066098/brown-s%C3%A3-quard-syndrome-and-cervical-post-traumatic-subarachnoid-hematoma
#7
Fernando Rascón-Ramírez, Josué M Avecillas-Chasín, Albert Trondin, M Javier Arredondo
Cervical Traumatic SSH are very rare in literature. They are usually caused by cardiopulmonary diseases that increase vascular pressure causing spinal vessels rupture. In thoracolumbar spine, the spinal puncture is the most common cause. The ventrolateral position is even more unusual. In traumatic brain injury (TBI), an abrupt extension-flexion movement could have caused the rupture of subarachnoid vessels. This, accompanied by the slowed blood "wash out" (probably due to the previous osteoarthrosis and spinal canal stenosis), led to the formation of an organized clot, which caused an acute spinal cord compression syndrome...
October 20, 2017: Neurocirugía
https://www.readbyqxmd.com/read/29037894/indentation-mapping-revealed-poroelastic-but-not-viscoelastic-properties-spanning-native-zonal-articular-cartilage
#8
Joseph A Wahlquist, Frank W DelRio, Mark A Randolph, Aaron H Aziz, Chelsea M Heveran, Stephanie J Bryant, Corey P Neu, Virginia L Ferguson
Osteoarthrosis is a debilitating disease affecting millions, yet engineering materials for cartilage regeneration has proven difficult because of the complex microstructure of this tissue. Articular cartilage, like many biological tissues, produces a time-dependent response to mechanical load that is critical to cell's physiological function in part due to solid and fluid phase interactions and property variations across multiple length scales. Recreating the time-dependent strain and fluid flow may be critical for successfully engineering replacement tissues but thus far has largely been neglected...
December 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28979851/electron-probe-microanalysis-%C3%B0-f-experimentally-stimulated-osteoarthrosis-in-dogs
#9
Tatyana Stupina, Michael Shchudlo, Michael Stepanov
AIM: To develop methods of articular cartilage preparation for X-ray-electron probe microanalysis and to study its elements content in experimental osteoarthrosis. METHODS: Twenty dogs aged 2-8 years were divided in research (aged 2 years, induction of osteoarthrosis - IOA) and intact group. Intact group included three subgroups (aged 2, 5 and 8 years). Samples of cartilage after araldite saturation and pouring were partially cut into semithin sections stained with methylene blue and with methylene blue-basic fuchsin...
September 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28966039/temporomandibular-disorder-otologic-implications-and-its-relationship-to-sleep-bruxism
#10
Bruno Gama Magalhães, Jaciel Leandro de Melo Freitas, André Cavalcanti da Silva Barbosa, Maria Cecília Scheidegger Neves Gueiros, Simone Guimarães Farias Gomes, Aronita Rosenblatt, Arnaldo de França Caldas Júnior
INTRODUCTION: Temporomandibular disorder is an umbrella term for various clinical problems affecting the muscles of mastication, temporomandibular joint and associated structures. This disorder has a multifactor etiology, with oral parafunctional habits considered an important co-factor. Among such habits, sleep bruxism is considered a causal agent involved in the initiation and/or perpetuation of temporomandibular disorder. That condition can result in pain otologic symptoms. OBJECTIVE: The aim of the present study was to investigate the relationship between temporomandibular disorder and both otologic symptoms and bruxism...
August 23, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28920791/femoral-head-resection-in-two-livingstone-s-fruit-bats-pteropus-livingstonii
#11
Alberto Rodriguez Barbon, Peter Rushton-Taylor, Edward Bell, Andrew Routh
Two Livingstone's fruit bats (Pteropus livingstonii) presented with a unilateral partial paresis of the hind limbs. Radiographs revealed luxation of the coxofemoral joint and degenerative joint disease in the right coxofemoral joint in one case. The second case presented with recurrent luxation of the coxofemoral joint with osteoarthrosis of the femoral head. Clinical findings in both cases led to a decision to perform a femoral head resection. The performed surgery led to the recovery of normal function of the limb without any complications in both cases...
September 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28913398/total-femur-arthroplasty-for-revision-hip-failure-in-osteogenesis-imperfecta-limits-of-biology
#12
Pablo Sanz-Ruiz, Manuel Villanueva-Martinez, Jose Antonio Calvo-Haro, Esther Carbó-Laso, Javier Vaquero-Martín
Osteogenesis imperfecta (OI) is a rare congenital disease characterized by alterations in bone quality, with susceptibility to fractures, instability, deformities, and osteoarthrosis. Prosthetic surgery in these patients is associated with an abnormally high rate of implant failures. On the other hand, abnormal bone fragility adds to the complexity of revision surgery in such individuals-thus representing a genuine challenge for the orthopaedic surgeon. We present a case of femoral reconstruction in a patient with OI and prosthetic loosening after reconstruction secondary to femoral septic pseudoarthrosis...
September 2017: Arthroplasty Today
https://www.readbyqxmd.com/read/28904969/sociodemographic-and-clinical-characteristics-of-centenarians-in-mexico-city
#13
Valdés-Corchado Pedro, Ruiz-Hernández Arturo, Pérez-Moreno Alejandro, Rosas-Carrasco Oscar
BACKGROUND: There is little evidence about the demography and health status of adults aged 100 years and over in Latin America and there are no studies in Mexico. OBJECTIVES: To describe the demographic characteristics and health status of centenarians residing in Mexico City. METHODS: This is a cross-sectional study using a population base of 393 community-dwelling centenarians in Mexico City. A comprehensive geriatric assessment was performed, including demographic information and health status...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28888229/changes-in-ankle-joint-motion-after-supramalleolar-osteotomy-a-cadaveric-model
#14
Hak Jun Kim, Eui Dong Yeo, Im Joo Rhyu, Soon-Hyuck Lee, Yeon Soo Lee, Young Koo Lee
BACKGROUND: Malalignment of the ankle joint has been found after trauma, by neurological disorders, genetic predisposition and other unidentified factors, and results in asymmetrical joint loading. For a medial open wedge supramalleolar osteotomy(SMO), there are some debates as to whether concurrent fibular osteotomy should be performed. We assessed the changes in motion of ankle joint and plantar pressure after supramalleolar osteotomy without fibular osteotomy. METHODS: Ten lower leg specimens below the knee were prepared from fresh-frozen human cadavers...
September 9, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28868088/chondral-defects-of-the-glenohumeral-joint-long-term-outcome-after-microfracturing-of-the-shoulder
#15
Sophia M Hünnebeck, Petra Magosch, Peter Habermeyer, Markus Loew, Sven Lichtenberg
INTRODUCTION: An increasing number of young patients are diagnosed with chondral lesions. Minimally invasive surgical techniques are important in order to delay progression of the early stages of osteoarthritis and the need for total joint replacement. MATERIALS AND METHODS: Patients (n = 32) who had received microfracturing of the shoulder were retrospectively enrolled, of whom 5 had received shoulder replacements after a mean time of 47 months. Of these patients, 23 completed the Disabilities of the Arm, Shoulder and Hand (DASH) and Constant-Murley Scores in addition to an additional subjective questionnaire...
2017: Obere Extremität
https://www.readbyqxmd.com/read/28861285/pattern-analysis-of-patients-with-temporomandibular-disorders-resulting-from-unilateral-mastication-due-to-chronic-periodontitis
#16
Hye-Mi Jeon, Yong-Woo Ahn, Sung-Hee Jeong, Soo-Min Ok, Jeomil Choi, Ju-Youn Lee, Ji-Young Joo, Eun-Young Kwon
PURPOSE: The purpose of the present study was to perform a pattern analysis in patients with temporomandibular disorder (TMD) resulting from unilateral mastication due to chronic periodontitis. METHODS: Thirty participants with signs or symptoms of TMD who engaged in unilateral mastication due to periodontitis-related discomfort (test group) were selected. Another 30 subjects exhibiting signs or symptoms of TMD resulting from unilateral mastication not due to chronic periodontitis (control group) were also recruited...
August 2017: Journal of Periodontal & Implant Science
https://www.readbyqxmd.com/read/28829651/experiences-with-osteoligamentoplasty-according-to-weiss-for-the-treatment-of-scapholunate-dissociation
#17
W Petersen, J Rothenberger, H E Schaller, A Rahmanian-Schwarz, M Held
BACKGROUND: In post-traumatic, dynamic, or static scapholunate (SL) instability, an SL ligament reconstruction is advisable to avoid long-term complications. However, a sufficient primary reconstruction is best achieved in acute injuries. For chronic SL dissociation, there is still no satisfying standard surgical technique. In this context, we evaluated the clinical outcome of Weiss's osteoligamentoplasty as a treatment option. METHODS: Over a three-year period, 16 patients with chronic and symptomatic SL dissociation Grade-II and III, without the signs of osteoarthrosis were, surgically treated using a bone-retinaculum-bone autograft from the distal radius...
August 22, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/28809636/-arthroscopic-finding-of-knee-joint-in-relation-to-age-and-its-comparison-with-pre-operative-clinical-finding-a-retrospective-study
#18
P Látal, K Šimeček, M Kloub
PURPOSE OF THE STUDY In the retrospective study of two South Bohemian centres we present the comparison of pre-operative anamnestic clinical signs in relation to the arthroscopic intraoperative finding. The obtained data is used also to evaluate the arthroscopic finding in relation to age and sex. MATERIAL AND METHODS The arthroscopic findings of patients who underwent surgery in 2013-2014 period (1.1.2013-31.12.2014) at the Department of Trauma Surgery of České Budějovice Hospital, a.s. and in 2014 (1.1...
2017: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
https://www.readbyqxmd.com/read/28759525/ultrasound-and-pet-ct-correlation-in-shoulder-pathology-a-5-year-retrospective-analysis
#19
Christopher J Burke, William R Walter, Ronald S Adler, James S Babb, Joseph Sanger, Fabio Ponzo
PURPOSE: To correlate shoulder ultrasound and radiography with F-FDG PET-CT to establish FDG uptake and therefore range of metabolic activity, as defined by SUV analysis, in various symptomatic shoulder pathologies. METHODS: Retrospective database query was performed for shoulder ultrasound and PET-CT scans between January 2012 and January 2017. Patients who had both studies within 1 year were included. Age- and sex-matched control patients with PET-CT scans only were also included...
October 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28752939/effect-of-organic-silicon-methylsulfonylmethane-and-glucosamine-sulfate-in-mandibular-bone-defects-in-rats
#20
Flávia Santiago de Sousa Rosa, Rúbia Teodoro Stuepp, Filipe Modolo, Michelle Tillmann Biz
Organic silicon (OS), glucosamine sulfate (GS), and methylsulfonylmethane (MSM) have been related to bone and connective tissue health and have been considered as basic therapy for osteoarthrosis disorders. Therefore, the aim was to analyze the effect of the association of these three components in mandibular bone defects in rats. Nine rats were used for histocompatibility test. In each animal was implanted the composition (70% OS, 15% GS, 15% MSM) and gutta percha (control) under the dorsal subcutaneous tissue...
November 2017: Microscopy Research and Technique
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