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S Fiorucci, E Distrutti
Traditional nonsteroidal anti-inflammatory drugs, tNSAIDs, are effective medication for prevention of ischemic events and treatment of pain, fever and inflammation. However their use associates with a significant risk to develop gastrointestinal and cardiovascular complications. Low doses of acetyl salicylic acid (ASA) and effective doses of tNSAIDs associate with a 2-6 fold increase in the risk of gastrointestinal bleeding. ASA and tNSAIDs inhibit cyclooxygenases (COXs). The COX exists at least in two isoforms, COX-1 and COX-2...
2011: Current Medicinal Chemistry
A J Dwyer, B John, S A Singh, M K Mam
Thirty-five consecutive patients with unilateral posterior dislocation of the hip were studied for complications at an average follow-up of 4.6 years (range 2-10 years). Thompson-Epstein type IV dislocation was most frequent (10/35), reflecting an increase in high-speed motor vehicles in the developing countries. It is also a severe injury that leads to a maximum number of complications, which include avascular necrosis, osteoarthosis, sciatic nerve injury and heterotrophic ossification. Avascular necrosis and osteoarthritis of the hip were observed maximally in type IV patients, even when reduction was achieved in less than twelve hours and may reflect the severity of initial injury...
August 2006: International Orthopaedics
Hisashi Yoshimoto, Shigenobu Sato, Takeshi Masuda, Taiki Kanno, Motoyuki Shundo, Takahiko Hyakumachi, Yasushi Yanagibashi
STUDY DESIGN: A retrospective, age- and sex-matched radiographic study. OBJECTIVES: To investigate the spinopelvic alignment in patients with osteoarthosis of the hip (HOA) and those with low back pain (LBP) and to determine the characteristics and differences in both groups. SUMMARY OF BACKGROUND DATA: Hip-spine syndrome, first described by Offierski and MacNab, is quite an important pathology when treating patients with pain in their low back and lower extremities...
July 15, 2005: Spine
A U J Yap, E K Chua, J K E Hoe
This study investigated the clinical temporomandibular disorders (TMD), pain-related disability and psychological status of TMD patients using a computerized on-line TMD diagnostic system (NUS TMD v1.1). A total of 107 patients (32 male, 75 female) referred to the TMD clinics at the National Dental Centre and National University Hospital participated in this study. The mean age of the predominantly Chinese population (82.2%) was 30.8 years (range from 12 to 64 years). The history questionnaire and clinical examination were input directly into computers by patients and clinicians...
April 2002: Journal of Oral Rehabilitation
M A Pollatschek, A M Nahir
Osteoarthrosis is modeled by a set of differential equations, i.e. equations giving the rate of deterioration of a given factor as a function of the state of the system. Here the system is the assembly of the factors and their deterioration rates, and the factors are the entities relevant to the model such as, for example, shock absorbance of the cartilage. The results are forecasted deteriorations of the factors. If laboratory and clinical findings corroborate our model, it may be accepted as a true description of the illness...
April 23, 1990: Journal of Theoretical Biology
H Ogus
An investigation into the involvement of the temporomandibular joint in rheumatoid arthritis is described. There is evidence to show that is is affected in two-thirds of all cases of the disease, and this figure agrees broadly with other recent studies. The clinical and radiographic presentation is discussed and its relationship to degenerative disease (osteoarthosis) of the temporomandibular joint is shown. The clinical course of this manifestation of rheumatoid arthritis is proposed and a line of treatment is suggested...
March 1975: British Journal of Oral Surgery
J C Gerster, T L Vischer, A Bennani, G H Fallet
This study presents the frequency of severe and mild talalgias in unselected, consecutive patients with rheumatoid arthritis, ankylosing spondylitis, Reiter's syndrome, and generalized osteoarthosis. Achilles tendinitis and plantar fasciitis caused a severe talalgia and they were observed mainly in males with Reiter's syndrome or ankylosing spondylitis. On the other hand, sub-Achilles bursitis more frequently affected women with rheumatoid arthritis and rarely gave rise to severe talalgias. The simple calcaneal spur was associated with generalized osteoarthrosis and its frequency increased with age...
August 1977: Annals of the Rheumatic Diseases
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