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https://www.readbyqxmd.com/read/29454252/human-papillomavirus-detection-using-pcr-and-atr-ftir-for-cervical-cancer-screening
#1
Taciana Rymsza, Eliane Aline Ribeiro, Luis Felipe das Chagas E Silva de Carvalho, Tanmoy Bhattacharjee, Renata de Azevedo Canevari
The human papillomavirus (HPV) genital infection is considered one of the most common sexually transmitted diseases worldwide, and has been associated with cervical cancer. The objective of this study was to investigate the efficacy of the diagnostic methods: polymerase chain reaction (PCR) and Fourier transform infrared (FTIR) equipped with an ATR (Attenuated Total Reflectance) unit (Pike Tech) spectroscopy, to diagnose HPV infection in women undergoing gynecological examination. Seventeen patients (41.46%) of the 41 patients analyzed were diagnosed with exophytic/condyloma acuminate lesions by clinical analysis, 29 patients (70...
February 5, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29454224/the-consonant-vowel-pattern-determines-the-structure-of-orthographic-representations-in-the-left-fusiform-gyrus
#2
Fabienne Chetail, Mariagrazia Ranzini, Xavier De Tiège, Vincent Wens, Alain Content
Recent findings demonstrated readers' sensitivity to the distinction between consonant and vowel letters. Especially, the way consonants and vowels are organised within written words determines their perceptual structure. The present work attempted to overcome two limitations of previous studies by examining the neurophysiological correlates of this perceptual structure through magnetoencephalography (MEG). One aim was to establish that the extraction of vowel-centred units takes place during early stages of processing...
February 2, 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29454209/reconciling-discrepancies-in-the-source-characterization-of-vocs-between-emission-inventories-and-receptor-modeling
#3
Jiamin Ou, Junyu Zheng, Zibing Yuan, Dabo Guan, Zhijiong Huang, Fei Yu, Min Shao, Peter K K Louie
Emission inventory (EI) and receptor model (RM) are two of the three source apportionment (SA) methods recommended by Ministry of Environment of China and used widely to provide independent views on emission source identifications. How to interpret the mixed results they provide, however, were less studied. In this study, a cross-validation study was conducted in one of China's fast-developing and highly populated city cluster- the Pearl River Delta (PRD) region. By utilizing a highly resolved speciated regional EI and a region-wide gridded volatile organic compounds (VOCs) speciation measurement campaign, we elucidated underlying factors for discrepancies between EI and RM and proposed ways for their interpretations with the aim to achieve a scientifically plausible source identification...
February 14, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29454184/exploration-and-exploitation-of-the-environment-for-novel-specialized-metabolites
#4
REVIEW
Catarina Loureiro, Marnix H Medema, John van der Oost, Detmer Sipkema
Microorganisms are Nature's little engineers of a remarkable array of bioactive small molecules that represent most of our new drugs. The wealth of genomic and metagenomic sequence data generated in the last decade has shown that the majority of novel biosynthetic gene clusters (BGCs) is identified from cultivation-independent studies, which has led to a strong expansion of the number of microbial taxa known to harbour BGCs. The large size and repeat sequences of BGCs remain a bioinformatic challenge, but newly developed software tools have been created to overcome these issues and are paramount to identify and select the most promising BGCs for further research and exploitation...
February 14, 2018: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/29454141/a-cluster-randomized-pilot-trial-of-a-tailored-worksite-smoking-cessation-intervention-targeting-hispanic-latino-construction-workers-intervention-development-and-research-design
#5
Taghrid Asfar, Alberto J Caban-Martinez, Laura A McClure, Estefania C Ruano-Herreria, Danielle Sierra, G Gilford Clark, Daniel Samano, Noella A Dietz, Kenneth D Ward, Kristopher L Arheart, David J Lee
Construction workers have the highest smoking rate among all occupations (39%). Hispanic/Latino workers constitute a large and increasing group in the US construction industry (over 2.6 million; 23% of all workers). These minority workers have lower cessation rates compared to other groups due to their limited access to cessation services, and lack of smoking cessation interventions adapted to their culture and work/life circumstances. Formative research was conducted to create an intervention targeting Hispanic/Latino construction workers...
February 14, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29454092/analysis-of-human-papillomavirus-16-e6-e7-genes-and-long-control-region-in-cervical-samples-from-uruguayan-women
#6
Viviana Ramas, Santiago Mirazo, Sylvia Bonilla, Dora Ruchansky, Juan Arbiza
OBJECTIVE: This study aims to investigate the HPV16 variant distribution by sequence analyses of E6, E7 oncogenes and the Long Control Region (LCR), from cervical cells collected from Uruguayan women, and to reconstruct the phylogenetic relationships among variants. METHODS: Forty-seven HPV16 variants, obtained from women with HSIL, LSIL, ASCUS and NILM cytological classes were analyzed for LCR and 12 were further studied for E6 and E7. Detailed sequence comparison, genetic heterogeneity analyses and phylogenetic reconstruction were performed...
February 14, 2018: Gene
https://www.readbyqxmd.com/read/29454090/characterization-of-vasa-homolog-in-a-neotropical-catfish-jundi%C3%A3-rhamdia-quelen-molecular-cloning-and-expression-analysis-during-embryonic-and-larval-development
#7
Juliana M B Ricci, Emanuel R M Martinez, Arno J Butzge, Lucas B Doretto, Marcos A Oliveira, Robie Allan Bombardelli, Jan Bogerd, Rafael H Nóbrega
We have characterized the full-length vasa cDNA from Jundiá, Rhamdia quelen (Heptapteridae, Siluriformes). vasa encodes a member of the DEAD-box protein family of ATP-dependent RNA helicases. This protein is highly conserved among different organisms and its role is associated with RNA metabolism. In the majority of the investigated species, vasa is restricted to the germ cell lineage and its expression has been used to study germline development in many organisms, including fish. The deduced R. quelen vasa amino acid sequence displayed high similarity with Vasa protein sequences from other organisms, and did not cluster with PL10 or P68 DEAD-box protein subfamilies...
February 14, 2018: Gene
https://www.readbyqxmd.com/read/29454089/genome-wide-gene-expression-analysis-of-45-days-pregnant-fetal-cotyledons-vis-a-vis-non-pregnant-caruncles-in-buffalo-bubalus-bubalis
#8
Masoud Lotfan, Syed Azmal Ali, Munnalal Yadav, Suman Chuadhary, Manoj Kumar Jena, Sudarshan Kumar, Ashok Kumar Mohanty
The crosstalk between fetus and mother starts with the onset of placental attachment to the uterus. The cotyledons and caruncles are the two anatomically distinct structures that play a crucial role in this physiological communication. Using Agilent Gene Chip Genome microarray, we measured the expression profile of pregnancy cotyledons in comparison to caruncular reminiscence of the uteri in non-pregnant buffalo (Bubalus bubalis) for the detection of the early post-pregnancy rapid changes in cellular expression of mRNA transcripts...
February 14, 2018: Gene
https://www.readbyqxmd.com/read/29453963/significance-of-spread-through-air-spaces-in-resected-pathological-stage-i-lung-adenocarcinoma
#9
Gouji Toyokawa, Yuichi Yamada, Tetsuzo Tagawa, Yuka Kozuma, Taichi Matsubara, Naoki Haratake, Shinkichi Takamori, Takaki Akamine, Yoshinao Oda, Yoshihiko Maehara
BACKGROUND: Spread through air spaces (STAS) is a recently described invasive pattern of lung cancer, which spreads within air spaces beyond the edge of the main tumor. In the current study, we investigated the significance of STAS in patients with pathological stage I adenocarcinoma. METHODS: STAS was assessed in a total of 276 patients with resected pathological stage I adenocarcinoma. STAS was classified as either no STAS, low STAS (1-4 single cells or clusters of STAS), or high STAS (≥5 single cells or clusters of STAS) using a 20x objective and a 10x ocular lens...
February 14, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29453948/noncritical-signaling-role-of-a-kinase-receptor-interaction-surface-in-the-escherichia-coli-chemosensory-core-complex
#10
Germán E Piñas, Michael D DeSantis, John S Parkinson
In E. coli chemosensory arrays, transmembrane receptors, a histidine autokinase CheA, and a scaffolding protein CheW interact to form an extended hexagonal lattice of signaling complexes. One interaction, previously assigned a crucial signaling role, occurs between chemoreceptors and the CheW-binding P5 domain of CheA. Structural studies showed a receptor helix fitting into a hydrophobic cleft at the boundary between P5 subdomains. Our work aimed to elucidate the in vivo roles of the receptor-P5 interface, employing as a model the interaction between E...
February 14, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29453926/sleep-disorder-prevalence-in-at-risk-adolescents-and-potential-effects-of-nightmare-triad-syndrome
#11
Natalia D McIver, Barry Krakow, Jessica Krakow, Michael R Nadorff, Victor A Ulibarri, Robert Baade
Objective At-risk high school students, those considered to have a higher probability for academic failure or dropping out, were assessed for various sleep disorders. Effects were compared between students with and without the nightmare triad syndrome (NTS+), the sleep disorders' cluster of frequent nightmares, insomnia disorder and suspected sleep-disordered breathing (SDB). Methods Data were gathered at a charter school for at-risk youth using: computer based surveys, physical airway exams, and mental health interviews by school social worker...
February 17, 2018: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/29453919/genetic-and-epigenetic-differences-of-benign-and-malignant-pheochromocytomas-and-paragangliomas-ppgls
#12
Fatemeh Khatami, Mahsa Mohammadamoli, Seyed Mohammad Tavangar
Pheochromocytomas and paragangliomas (PPGLs) are tumors arising from the adrenal medulla and sympathetic/parasympathetic paraganglia, respectively. According to Th e Cancer Genome Atlas (TCGA), approximately 40% of PPGLs are due to germ line mutations in one of 16 susceptibility genes, and a further 30% are due to somatic alterations in at least seven main genes (VHL, EPAS1, CSDE1, MAX, HRAS, NF1, RET, and possibly KIF1B). Th e diagnosis of malignant PPGL was straight forward in most cases as it was defined as presence of PPGL in non-chromaffin tissues...
January 1, 2018: Endocrine Regulations
https://www.readbyqxmd.com/read/29453894/organisation-of-lymphocytic-infiltrates-inanca-associated-glomerulonephritis
#13
Silke R Brix, Mercedes Noriega, Elisabeth M Herden, Birgit Goldmann, Ulrike Langbehn, Martin Busch, Wolfram J Jabs, Oliver M Steinmetz, Ulf Panzer, Tobias B Huber, Rolf A K Stahl, Thorsten Wiech
AIMS: Renal involvement in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis contributes to significant morbidity and mortality in patients. In chronic inflammation, B cells are recruited to the inflamed tissue and organised lymphoid structures have been described in several autoimmune diseases. Aim of this study was to correlate the lymphoid organisation in renal biopsies with renal outcome in ANCA-associated glomerulonephritis (GN). METHODS AND RESULTS: We investigated 112 renal biopsies from patients with newly diagnosed ANCA-associated necrotizing GN...
February 17, 2018: Histopathology
https://www.readbyqxmd.com/read/29453877/significance-of-mitochondria-on-cardiometabolic-syndromes
#14
REVIEW
Nair Anupama, G Sindhu, K G Raghu
Metabolic syndromes (MS) are a cluster of disorders like obesity, hypertension, dyslipidemia, and diabetes. Cardiometabolic syndrome (CMS), a branch of MS, is a group of diseases affecting cardiovascular, renal, metabolic, prothrombotic and inflammatory abnormalities due to defects in energy metabolism. Since the emergence of molecular biology and the discovery of pathogenic mitochondrial DNA defect in the 1980s, research advances has revealed a number of common human disease involving mitochondrial dysfunction...
February 17, 2018: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/29453852/a-sulfonozanamivir-analogue-has-potent-anti-influenza-virus-activity
#15
Ádám Hadházi, Linghui Li, Benjamin Bailly, Andrea Maggioni, Gael Martin, Larissa Dirr, Jeffrey Dyason, Robin Thomson, George Gao, Anikó Borbás, Thomas Ve, Mauro Pascolutti, Mark von Itzstein
Influenza virus infection continues to cause significant, often severe, respiratory illness worldwide. A validated target for development of anti-influenza agents is the viral surface protein sialidase. In the current study, we have discovered a highly potent inhibitor of influenza virus sialidase, based on a novel sialosyl sulfonate template. The synthesised 3-guanidino sialosyl α-sulfonate, a sulfonozanamivir analogue, inhibits virus replication in vitro at a nanomolar level, comparable to that of anti-influenza drug zanamivir...
February 17, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29453769/hpv-genotyping-for-the-cross-sectional-and-longitudinal-probability-of-developing-cin2
#16
Annarosa Del Mistro, Rachael Adcock, Francesca Carozzi, Anna Gillio-Tos, Laura De Marco, Salvatore Girlando, Raffaella Rizzolo, Helena Frayle, Morena Trevisan, Cristina Sani, Elena Burroni, Paolo Giorgi Rossi, Jack Cuzick, Guglielmo Ronco
HPV testing is more sensitive but less specific than cytology. We evaluated stand-alone genotyping as a possible triage method. During a multicentre randomised controlled trial comparing HPV testing to conventional cytology, HPV positive women were referred to colposcopy and followed up if no high-grade lesion was detected. HPV positive samples were genotyped by GP5+/GP6+ primed PCR followed by reverse line blot. Genotypes were hierarchically ordered by positive predictive value (PPV) for CIN grade 2 or more (CIN2+), and grouped by cluster analysis into 3 groups (A, B and C in decreasing order)...
February 17, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29453739/how-is-civic-engagement-related-to-personal-identity-and-social-identity-in-late-adolescents-and-emerging-adults-a-person-oriented-approach
#17
Lyda Lannegrand-Willems, Basilie Chevrier, Cyrille Perchec, Alexia Carrizales
Adolescence and emerging adulthood are periods in life when individuals both question and define their place in society and form their identity. Meanwhile, active youth civic engagement represents a challenge for each democracy. The purpose of this study was to analyze the different forms of civic engagement among late adolescents and emerging adults and how they are related to personal identity and social identity, while adopting an integrative perspective through the lens of a person-oriented approach. The participants were 1217 (62...
February 16, 2018: Journal of Youth and Adolescence
https://www.readbyqxmd.com/read/29453667/dissolved-organic-matter-characteristics-along-sabo-dammed-streams-based-on-ultraviolet-visible-and-fluorescence-spectral-properties
#18
Susan Praise, Hiroaki Ito, Ying An, Kazuya Watanabe, Toru Watanabe
Changes in dissolved organic matter (DOM) characteristics were investigated in two mountainous streams with closed-type sabo dams. Surface water was collected from four stations along the two mountainous streams and analyzed using ultraviolet-visible spectrophotometry and excitation-emission fluorescence matrix (EEM) methods. Optical properties of DOM indicated an increase in molecular weight and aromaticity at stations near the sabo dams. Average spectral ratio values were low before and after the dam (i.e...
February 17, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29453622/cognitive-mediators-of-change-in-physical-functioning-in-response-to-a-multifaceted-intervention-for-managing-osteoarthritis
#19
Shannon Stark Taylor, Eugene Z Oddone, Cynthia J Coffman, Amy S Jeffreys, Hayden B Bosworth, Kelli D Allen
PURPOSE: Although non-pharmacological interventions have been shown to improve physical functioning in individuals with osteoarthritis (OA), the mechanisms by which this occurs are often unclear. This study assessed whether changes in arthritis self-efficacy, perceived pain control, and pain catastrophizing mediated changes in physical functioning following an osteoarthritis intervention involving weight management, physical activity, and cognitive-behavioral pain management. METHOD: Three hundred Veteran patients of 30 primary care providers with knee and/or hip OA were cluster randomized to an OA intervention group or usual care...
February 16, 2018: International Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/29453589/validity-of-triglyceride-glucose-index-as-an-indicator-for-metabolic-syndrome-in-children-and-adolescents-the-caspian-v-study
#20
Pooneh Angoorani, Ramin Heshmat, Hanieh-Sadat Ejtahed, Mohammad Esmaeil Motlagh, Hasan Ziaodini, Majzoubeh Taheri, Tahereh Aminaee, Azam Goodarzi, Mostafa Qorbani, Roya Kelishadi
PURPOSE: The purpose of this study was to determine the cut-off values of triglycerides and glucose (TyG) index as one of the indirect indices for metabolic syndrome (MetS) in a pediatric population. METHODS: This national study was conducted in 2015 on 14400 students, aged 7-18 years. They were selected by random cluster sampling from 30 provinces of our country during the fifth survey of a national school-based surveillance program. MetS was defined based on the Adult Treatment Panel III (ATP III) criteria modified for the pediatric age group...
February 16, 2018: Eating and Weight Disorders: EWD
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