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https://www.readbyqxmd.com/read/28102966/histone-deacetylase-2-is-decreased-in-peripheral-blood-pro-inflammatory-cd8-t-and-nkt-like-lymphocytes-following-lung-transplant
#1
Greg Hodge, Sandra Hodge, Chien-Li Holmes-Liew, Paul N Reynolds, Mark Holmes
BACKGROUND AND OBJECTIVE: Immunosuppression therapy following lung transplantation fails to prevent chronic rejection in many patients, which is associated with lack of suppression of cytotoxic mediators and pro-inflammatory cytokines in peripheral blood T and natural killer T (NKT)-like cells. Histone acetyltransferases (HATs) and histone deacetylases (HDACs) upregulate/downregulate pro-inflammatory gene expression, respectively; however, differences in the activity of these enzymes following lung transplant are unknown...
February 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28102943/comparison-of-five-cluster-validity-indices-performance-in-brain-18-f-fet-pet-image-segmentation-using-k-means
#2
Bedor Abualhaj, Guoyang Weng, Melissa Ong, Ali Asgar Attarwala, Flavia Molina, Karen Büsing, Gerhard Glatting
PURPOSE: Dynamic [(18) F]fluoro-ethyl-L-tyrosine positron emission tomography ([(18) F]FET-PET) is used to identify tumor lesions for radiotherapy treatment planning, to differentiate glioma recurrence from radiation necrosis and to classify gliomas grading. To segment different regions in the brain k-means cluster analysis can be used. The main disadvantage of k-means is that the number of clusters must be pre-defined. In this study, we therefore compared different cluster validity indices for automated and reproducible determination of the optimal number of clusters based on the dynamic PET data...
January 2017: Medical Physics
https://www.readbyqxmd.com/read/28102897/controls-on-methane-occurrences-in-shallow-aquifers-overlying-the-haynesville-shale-gas-field-east-texas
#3
Jean-Philippe Nicot, Toti Larson, Roxana Darvari, Patrick Mickler, Michael Slotten, Jordan Aldridge, Kristine Uhlman, Ruth Costley
Understanding the source of dissolved methane in drinking-water aquifers is critical for assessing potential contributions from hydraulic fracturing in shale plays. Shallow groundwater in the Texas portion of the Haynesville Shale area (13,000 km(2) ) was sampled (70 samples) for methane and other dissolved light alkanes. Most samples were derived from the fresh water bearing Wilcox formations and show little methane except in a localized cluster of 12 water wells (17% of total) in a approximately 30 × 30 km(2) area in Southern Panola County with dissolved methane concentrations less than 10 mg/L...
January 19, 2017: Ground Water
https://www.readbyqxmd.com/read/28102753/chloroplastic-iron-sulfur-scaffold-protein-nfu3-is-essential-to-overall-plant-fitness
#4
Krishna Nath, James P O'Donnell, Yan Lu
A previous study showed that Nitrogen-Fixing-subunit-U-type protein NFU3 may act an iron-sulfur scaffold protein in the assembly and transfer of 4Fe-4S and 3Fe-4S clusters in the chloroplast. Examples of 4Fe-4S and 3Fe-4S-requiring proteins and complexes include Photosystem I (PSI), NAD(P)H dehydrogenase, and ferredoxin-dependent glutamine oxoglutarate aminotransferases. In this paper, the authors provided additional evidence for the role of NFU3 in 4Fe-4S and 3Fe-4S cluster assembly and transfer, as well as its role in overall plant fitness...
January 19, 2017: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/28102672/coupled-cluster-studies-of-ionization-potentials-and-electron-affinities-of-single-walled-carbon-nanotubes
#5
Bo Peng, Niranjan Govind, Edoardo Aprà, Michael Klemm, Jeff R Hammond, Karol Kowalski
In this paper we apply the equation-of-motion coupled cluster (EOM-CC) methods in the studies of the vertical ionization potentials (IPs) and electron affinities (EAs) for a series of single walled carbon nanotubes (SWCNT). The EOM-CC formulations for IPs and EAs employing excitation manifolds spanned by single and double excitations (IP/EA-EOM-CCSD) are used to study the IPs and EAs of the SWCNTs as a func- tion of the nanotube length. Several armchair nanotubes corresponding to C20nH20 models with n = 2 - 6 have been used in benchmark calculations...
January 19, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28102538/comparing-early-liver-graft-function-from-heart-beating-and-living-donors-a-pilot-study-aiming-to-identify-new-biomarkers-of-liver-injury
#6
Qi Joy Yang, Michael Kluger, Krzysztof Goryński, Janusz Pawliszyn, Barbara Bojko, Ai-Ming Yu, Keumhan Noh, Markus Selzner, Angela Jerath, Stuart McCluskey, K Sandy Pang, Marcin Wąsowicz
: Liver and kidney functions among recipients of liver transplantation (LT) surgery with heart beating (HBD, n = 13) or living donors (LD, n = 9) with different cold ischemic times were examined during the neohepatic phase for clearing rocuronium bromide (ROC, cleared by liver and kidney) and tranexamic acid (TXA, cleared by kidney). Solid phase micro-extraction and LC-MS/MS was applied to determine the plasma concentrations of ROC and TXA, and creatinine was determined by standard laboratory methods...
January 19, 2017: Biopharmaceutics & Drug Disposition
https://www.readbyqxmd.com/read/28102516/production-of-lovastatin-and-itaconic-acid-by-aspergillus-terreus-a-comparative-perspective
#7
REVIEW
Tomasz Boruta, Marcin Bizukojc
Aspergillus terreus is a textbook example of an industrially relevant filamentous fungus. It is used for the biotechnological production of two valuable metabolites, namely itaconic acid and lovastatin. Itaconic acid serves as a precursor in polymer industry, whereas lovastatin found its place in the pharmaceutical market as a cholesterol-lowering statin drug and a precursor for semisynthetic statins. Interestingly, their biosynthetic gene clusters were shown to reside in the common genetic neighborhood. Despite the genomic proximity of the underlying biosynthetic genes, the production of lovastatin and itaconic acid was shown to be favored by different factors, especially with respect to pH values of the broth...
February 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28102505/maternal-characteristics-and-incidence-of-overweight-obesity-in-children-a-13-year-follow-up-study-in-an-eastern-mediterranean-population
#8
Sara Jalali-Farahani, Parisa Amiri, Behnood Abbasi, Mehrdad Karimi, Leila Cheraghi, Maryam Sadat Daneshpour, Fereidoun Azizi
Objectives To investigate clustering of parental sociobehavioral factors and their relationship with the incidence of overweight and obesity in Iranian children. Methods Demographics, body weight, and certain medical characteristics of the parents of 2999 children were used to categorize parents by cluster; children's weights were assessed for each cluster. Specifically, survival analysis and Cox regression models were used to test the effect of parental clustering on the incidence of childhood overweight and obesity...
January 19, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28102496/oil-exploration-activities-assessment-of-hazardous-impacts-on-golden-silk-cultivation
#9
Gitumani Devi, Arundhuti Devi, K G Bhattacharyya
Aliphatic-aromatic hydrocarbons and heavy metals (Cd, Cu, Co, Cr, Ni, Pb and Zn) were estimated in soil and leaf samples of Machilus bombycina (host plant of Antheraea assama silkworm) plantation along with atmospheric benzene, toluene and xylene (BTX) concentration near the oil exploration region of upper Assam, India, during the pre-monsoon and post-monsoon periods in six different sites. The results revealed higher aliphatic-aromatic hydrocarbons (ranging from 26.55 to 59.42 mg kg(-1)) and heavy metal contaminations in all the six soil sampling sites during the pre-monsoon period while the trend was the opposite for the plant leaves...
February 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28102479/peripherally-inserted-central-catheter-related-bloodstream-infection-caused-by-kocuria-marina-in-an-elderly-man
#10
Nobuaki Mori, Yuichi Nishihara, Hideki Tayama, Akiko Higuchi, Yasuko Aoki
BACKGROUND: Kocuria species are Gram-positive, aerobic cocci, and members of the Micrcoccaceae family that are known to be opportunistic pathogens. Although there have been sporadic reports of infections caused by Kocuria species, little is known regarding their human pathogenicity and clinical characteristics. CASE REPORT: We herein report a case of a peripherally inserted central catheter (PICC)-related bloodstream infection caused by Kocuria marina in a 90-year-old Japanese with multiple cancer...
January 19, 2017: Infection
https://www.readbyqxmd.com/read/28102428/plasma-adamts13-activity-and-von-willebrand-factor-antigen-and-activity-in-patients-with-subarachnoid-haemorrhage
#11
Monisha Kumar, Wenjing Cao, Jenny K McDaniel, Huy P Pham, Dheeraj Raju, Kelsey Nawalinski, Suzanne Frangos, David Kung, Eric Zager, Scott E Kasner, Joshua M Levine, X Long Zheng
Increased von Willebrand factor (VWF) and reduced ADAMTS13 activity are associated with arterial thrombosis. This may also be the culprit mechanism implicated in delayed cerebral ischaemia after aneurysmal subarachnoid haemorrhage (SAH). It was our objective to determine plasma VWF and ADAMTS13 in patients with SAH and healthy subjects; and to explore the levels of those markers and outcome after SAH. Forty consecutive patients were enrolled between September 2007 and April 2014 in a pilot study. Plasma samples were collected from SAH patients on post-bleed day (PBD) 0, 1, 3, 5, 7 and 10 and healthy controls...
January 19, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28102387/anion-dependent-self-assembly-of-sandwich-13-metal-ni-ln-nanoclusters-with-a-long-chain-schiff-base-ligand
#12
Shiqing Wang, Xiaoping Yang, Jinjie Qian, Qipeng Li, Zhongning Chen, Lijie Zhang, Shaoming Huang, Chengri Wang, Richard A Jones
Two classes of Ni-Ln clusters [Ln4Ni3L3(OAc)6(NO3)3(OH)3] (Ln = Gd (1) and Tb (2)) and [Ln6Ni7L6(OAc)12(OH)6](OH)2 (Ln = Gd (3) and Dy (4)) were prepared using a specifically designed Schiff base ligand built around a flexible (CH2)2O(CH2)2O(CH2)2 chain. 1 and 2 exhibit cone-like structures, while 3 and 4 have nanosized sandwich architectures. The structures were studied by single-crystal X-ray diffraction and TEM, and magnetic properties were investigated.
January 19, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28102374/ethane-c-h-bond-activation-on-the-fe-iv-oxo-species-in-a-zn-based-cluster-of-metal-organic-frameworks-a-density-functional-theory-study
#13
Sarawoot Impeng, Siwarut Siwaipram, Sareeya Bureekaew, Michael Probst
We first investigate the feasibility of designing a Fe-oxo complex for the activation of alkane C-H bonds by (a) incorporating an Fe ion into a Zn-based cluster derived from a metal-organic framework (MOF) and (b) creating the Fe-oxo complex via decomposition of N2O over a Fe(2+)-substituted Zn-based cluster (Fe-Zn3O(pyrazole)6). From the energy profile, it turns out that both steps should be feasible and that the resulting Fe-oxo complex is stable. In the main step, we then investigate the reactivity of this Fe-oxo cluster for the C-H bond cleavage of ethane by calculating the reaction energy profile and analyzing the electronic structure along the relevant steps...
January 19, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28102357/a-single-identified-glomerulus-in-the-zebrafish-olfactory-bulb-carries-the-high-affinity-response-to-death-associated-odor-cadaverine
#14
Milan Dieris, Gaurav Ahuja, Venkatesh Krishna, Sigrun I Korsching
The death-associated odor cadaverine, generated by bacteria-mediated decarboxylation of lysine, has been described as the principal activator of a particular olfactory receptor in zebrafish, TAAR13c. Low concentrations of cadaverine activated mainly TAAR13c-expressing olfactory sensory neurons, suggesting TAAR13c as an important element of the neuronal processing pathway linking cadaverine stimulation to a strongly aversive innate behavioral response. Here, we characterized the initial steps of this neuronal pathway...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28102318/transcriptional-profiling-of-olfactory-system-development-identifies-distal-antenna-as-a-regulator-of-subset-of-neuronal-fates
#15
Scott Barish, Qingyun Li, Jia W Pan, Charlie Soeder, Corbin Jones, Pelin C Volkan
Drosophila uses 50 different olfactory receptor neuron (ORN) classes that are clustered within distinct sensilla subtypes to decipher their chemical environment. Each sensilla subtype houses 1-4 ORN identities that arise through asymmetric divisions of a single sensory organ precursor (SOP). Despite a number of mutational studies investigating the regulation of ORN development, a majority of the transcriptional programs that lead to the different ORN classes in the developing olfactory system are unknown. Here we use transcriptional profiling across the time series of antennal development to identify novel transcriptional programs governing the differentiation of ORNs...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28102313/cultivation-and-energy-efficient-harvesting-of-microalgae-using-thermoreversible-sol-gel-transition
#16
Bendy Estime, Dacheng Ren, Radhakrishna Sureshkumar
Microalgae represent a promising source of renewable biomass for the production of biofuels and valuable chemicals. However, energy efficient cultivation and harvesting technologies are necessary to improve economic viability. A Tris-Acetate-Phosphate-Pluronic (TAPP) medium that undergoes a thermoreversible sol-gel transition is developed to efficiently culture and harvest microalgae without affecting the productivity as compared to that in traditional culture in a well-mixed suspension. After seeding microalgae in the TAPP medium in a solution phase at 15 °C, the temperature is increased by 7 °C to induce gelation...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28102295/bioactive-compounds-and-antioxidant-activity-of-wolfberry-infusion
#17
Yujing Sun, Japaer Rukeya, Wenyang Tao, Peilong Sun, Xingqian Ye
An infusion of the wolfberry (Lycium barbarum L.) is a traditional Asian herbal tea. This is the most commonly consumed form of dried wolfberry worldwide, yet little scientific information on wolfberry infusions is available. We investigated the effects of making infusions with hot water on the color, the content of bioactive compounds (polysaccharides, polyphenols, flavonoids and carotenoids) and the antioxidant ability of wolfberry infusions. The contents of bioactive compounds and the antioxidant activity of a wolfberry infusion increased with increased infusion temperature and time...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28102179/a-2-d-suspension-of-active-agents-the-role-of-fluid-mediated-interactions
#18
Hojjat Behmadi, Zahra Fazli, Ali Najafi
Taking into account both the Vicsek short range ordering and the far-field hydrodynamic interactions mediated by the ambient fluid, we investigate the role of long range interactions in the ordering phenomena in a quasi 2-dimensional active suspension. By studying the number fluctuations, the velocity correlation functions and cluster size distribution function, we show that depending on the number density of swimmers and the strength of noise, the hydrodynamic interactions can have significant effects in a suspension...
January 19, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28102081/deep-coverage-of-global-protein-expression-and-phosphorylation-in-breast-tumor-cell-lines-using-tmt-10-plex-isobaric-labeling
#19
Fang-Ke Huang, Guoan Zhang, Kevin Lawlor, Arpi Nazarian, John Philip, Paul Tempst, Noah Dephoure, Thomas A Neubert
Labeling peptides with isobaric tags is a popular strategy in quantitative bottom-up proteomics. In this study, we labeled six breast tumor cell lysates (1.34 mg proteins per channel) using 10-plex tandem mass tag reagents and analyzed the samples on a Q Exactive HF Quadrupole-Orbitrap mass spectrometer. We identified a total of 8706 proteins and 28186 phosphopeptides, including 7394 proteins and 23739 phosphosites common to all channels. The majority of technical replicates correlated with a R2 ≥ 0.98, indicating minimum variability was introduced after labeling...
January 19, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28102004/prevalence-and-causes-of-hearing-impairment-in-fundong-health-district-north-west-cameroon
#20
Silvia Ferrite, Islay Mactaggart, Hannah Kuper, Joseph Oye, Sarah Polack
OBJECTIVE: To estimate the prevalence and causes of hearing impairment in Fundong Health District, North West Cameroon. METHODS: We selected 51 clusters of 80 people through probability proportionate to size sampling. Initial hearing screening was undertaken through an otoacoustic emission (OAE) test. Participants aged 4+ years who failed this test in both ears or for whom an OAE reading could not be taken underwent a manual pure-tone audiometry (PTA) screening...
January 18, 2017: Tropical Medicine & International Health: TM & IH
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