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https://www.readbyqxmd.com/read/29223109/genome-wide-analysis-of-barrett-s-adenocarcinoma-a-first-step-towards-identifying-patients-at-risk-and-developing-therapeutic-paths
#1
Yiyang Dai, Qing Wang, Adrian Gonzalez Lopez, Mario Anders, Peter Malfertheiner, Michael Vieth, Wolfgang Kemmner
BACKGROUND: Barrett's esophagus metaplasia is the key precursor lesion of esophageal adenocarcinoma. The aim of this study was to find a subset of markers that may allow the identification of patients at risk for esophageal adenocarcinoma, and to determine genes differentially expressed in esophageal squamous cell carcinoma. METHODS: Laser capture microdissection technique was applied to procure cells from defined regions. Genome-wide RNA profiling was performed on esophageal adenocarcinoma (n = 21), Barrett's esophagus (n = 20), esophageal squamous carcinoma (n = 9) and healthy esophageal biopsies (n = 18) using the Affymetrix Human Genome U133plus 2...
December 6, 2017: Translational Oncology
https://www.readbyqxmd.com/read/29222953/bacterial-community-changes-in-copper-and-pex-drinking-water-pipeline-biofilms-under-extra-disinfection-and-magnetic-water-treatment
#2
Jenni Inkinen, Balamuralikrishna Jayaprakash, Merja Ahonen, Tarja Pitkänen, Riika Mäkinen, Anna Pursiainen, Jorge W Santo Domingo, Heidi Salonen, Michael Elk, Minna M Keinänen-Toivola
AIMS: To study stability of biofilms and water quality in pilot scale drinking water copper and PEX pipes in changing conditions (extra disinfection, magnetic water treatment MWT). METHODS AND RESULTS: Next-generation sequencing (NGS) of 16S ribosomal RNA genes (rDNA) to describe total bacterial community and ribosomal RNA (rRNA) to describe active bacterial members in addition to traditional microbiological methods were applied. Biofilms from control copper and PEX pipes shared same most abundant bacteria (Methylobacterium spp...
December 9, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29222836/biochemical-and-structural-insights-into-a-thermostable-cellobiohydrolase-from-myceliophthora-thermophila
#3
Marco Antonio Seiki Kadowaki, Paula Higasi, Mariana Ortiz de Godoy, Rolf A Prade, Igor Polikarpov
Cellobiohydrolases hydrolyze cellulose, a linear polymer with glucose monomers linked exclusively by β-1,4 glycosidic linkages. The widespread hydrogen bonding network tethers individual cellulose polymers forming crystalline cellulose, which prevent the access of hydrolytic enzymes and water molecules. The most abundant enzyme secreted by Myceliophthora thermophila M77 in response to the presence of biomass is the cellobiohydrolase MtCel7A, which is composed by a GH7-catalytic domain (CD), a linker and a CBM1-type carbohydrate binding module...
December 8, 2017: FEBS Journal
https://www.readbyqxmd.com/read/29222666/morphometric-variation-in-periglischrus-torrealbai-acari-spinturnicidae-on-three-species-of-host-bats-chiroptera-phyllostomidae-with-a-new-record-of-host-species
#4
Juliana Cardoso de Almeida, Luiz Antonio Costa Gomes, Robert D Owen
We evaluated morphometric variation of the mite Periglischrus torrealbai (Spinturnicidae) on three species of host bats: Phyllostomus discolor, P. hastatus, and Tonatia bidens (Phyllostomidae). A total of 67 females and 74 males of P. torrealbai were collected from 41 host individuals of these three bat species that were sampled in Brazil, Paraguay, and Peru. Twenty-one measurements from the dorsal side and 28 from the ventral side were recorded from female mites and 21 dorsal and 34 ventral measurements were taken from males...
December 8, 2017: Parasitology Research
https://www.readbyqxmd.com/read/29222633/characterising-youth-with-callous-unemotional-traits-and-concurrent-anxiety-evidence-for-a-high-risk-clinical-group
#5
Charlotte A M Cecil, Eamon J McCrory, Edward D Barker, Jo Guiney, Essi Viding
Growing evidence supports the existence of two variants of youth with high callous-unemotional (CU) traits who present with markedly different risk profiles and outcomes, with potential implications for risk assessment and treatment formulation. So far, studies have identified variants of CU youth mainly using data-driven cluster approaches based on levels of CU traits and co-occurring anxiety. Yet, the extent to which this knowledge may be translated into clinical practice is unclear. To this end, the present study employed a severity-based, cut-off approach to systematically characterise CU groups across a range of clinically informative domains, including trauma history, psychiatric symptomatology, affective functioning, attachment style and behavioural risk...
December 8, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29222572/word-processing-in-children-with-autism-spectrum-disorders-evidence-from-event-related-potentials
#6
Micheal Sandbank, Paul Yoder, Alexandra P Key
Purpose: This investigation was conducted to determine whether young children with autism spectrum disorders exhibited a canonical neural response to word stimuli and whether putative event-related potential (ERP) measures of word processing were correlated with a concurrent measure of receptive language. Additional exploratory analyses were used to examine whether the magnitude of the association between ERP measures of word processing and receptive language varied as a function of the number of word stimuli the participants reportedly understood...
December 8, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/29222464/the-irish-dna-atlas-revealing-fine-scale-population-structure-and-history-within-ireland
#7
Edmund Gilbert, Seamus O'Reilly, Michael Merrigan, Darren McGettigan, Anne M Molloy, Lawrence C Brody, Walter Bodmer, Katarzyna Hutnik, Sean Ennis, Daniel J Lawson, James F Wilson, Gianpiero L Cavalleri
The extent of population structure within Ireland is largely unknown, as is the impact of historical migrations. Here we illustrate fine-scale genetic structure across Ireland that follows geographic boundaries and present evidence of admixture events into Ireland. Utilising the 'Irish DNA Atlas', a cohort (n = 194) of Irish individuals with four generations of ancestry linked to specific regions in Ireland, in combination with 2,039 individuals from the Peoples of the British Isles dataset, we show that the Irish population can be divided in 10 distinct geographically stratified genetic clusters; seven of 'Gaelic' Irish ancestry, and three of shared Irish-British ancestry...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29222462/a-translational-model-to-determine-rodent-s-age-from-human-foetal-age
#8
Yoshiyuki Ohmura, Yasuo Kuniyoshi
To understand the prenatal origin of developmental and psychiatric disorders, studies in laboratory animals are imperative. However, the developmental pace differs between humans and animals; hence, corresponding human ages must be estimated to infer the most vulnerable developmental timings in humans. Because rats and mice are extensively used as models in developmental research, a correspondence between human foetal ages and rodents' ages must be precisely determined; thus, developing a translational model is of utmost importance...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29222455/binding-modes-of-teixobactin-to-lipid-ii-molecular-dynamics-study
#9
Yang Liu, Yaxin Liu, Mary B Chan-Park, Yuguang Mu
Teixobactin (TXB) is a newly discovered antibiotic targeting the bacterial cell wall precursor Lipid II (LII). In the present work, four binding modes of TXB on LII were identified by a contact-map based clustering method. The highly flexible binary complex ensemble was generated by parallel tempering metadynamics simulation in a well-tempered ensemble (PTMetaD-WTE). In agreement with experimental findings, the pyrophosphate group and the attached first sugar subunit of LII are found to be the minimal motif for stable TXB binding...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29222444/diazotroph-diversity-and-nitrogen-fixation-in-the-coral-stylophora-pistillata-from-the-great-barrier-reef
#10
Michael P Lesser, Kathleen M Morrow, Sabrina M Pankey, Sam H C Noonan
Diazotrophs, both Bacteria and Archaea, capable of fixing nitrogen (N2), are present in the tissues and mucous, of corals and can supplement the coral holobiont nitrogen budget with fixed nitrogen (N) in the form of ammonia (NH3). Stylophora pistillata from Heron Island on the Great Barrier Reef collected at 5 and 15 m, and experimentally manipulated in the laboratory, showed that the rates of net photosynthesis, steady state quantum yields of photosystem II (PSII) fluorescence (∆F v/F m') and calcification varied based on irradiance as expected...
December 8, 2017: ISME Journal
https://www.readbyqxmd.com/read/29222442/contrasting-patterns-of-genome-level-diversity-across-distinct-co-occurring-bacterial-populations
#11
Sarahi L Garcia, Sarah L R Stevens, Benjamin Crary, Manuel Martinez-Garcia, Ramunas Stepanauskas, Tanja Woyke, Susannah G Tringe, Siv G E Andersson, Stefan Bertilsson, Rex R Malmstrom, Katherine D McMahon
To understand the forces driving differentiation and diversification in wild bacterial populations, we must be able to delineate and track ecologically relevant units through space and time. Mapping metagenomic sequences to reference genomes derived from the same environment can reveal genetic heterogeneity within populations, and in some cases, be used to identify boundaries between genetically similar, but ecologically distinct, populations. Here we examine population-level heterogeneity within abundant and ubiquitous freshwater bacterial groups such as the acI Actinobacteria and LD12 Alphaproteobacteria (the freshwater sister clade to the marine SAR11) using 33 single-cell genomes and a 5-year metagenomic time series...
December 8, 2017: ISME Journal
https://www.readbyqxmd.com/read/29222390/sodium-channel-remodeling-in-subcellular-microdomains-of-murine-failing-cardiomyocytes
#12
Mathilde R Rivaud, Esperanza Agullo-Pascual, Xianming Lin, Alejandra Leo-Macias, Mingliang Zhang, Eli Rothenberg, Connie R Bezzina, Mario Delmar, Carol Ann Remme
BACKGROUND: Cardiac sodium channel (NaV1.5) dysfunction contributes to arrhythmogenesis during pathophysiological conditions. Nav1.5 localizes to distinct subcellular microdomains within the cardiomyocyte, where it associates with region-specific proteins, yielding complexes whose function is location specific. We herein investigated sodium channel remodeling within distinct cardiomyocyte microdomains during heart failure. METHODS AND RESULTS: Mice were subjected to 6 weeks of transverse aortic constriction (TAC; n=32) to induce heart failure...
December 8, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29222362/randomized-controlled-evaluation-of-an-insulin-pen-storage-policy
#13
Haley G Gibbs, Tara McLernon, Rosemary Call, Katie Outten, Leigh Efird, Peter A Doyle, Elizabeth A Stuart, Nestoras Mathioudakis, Nicole Glasgow, Avadhut Joshi, Pravin George, Bob Feroli, Elizabeth K Zink
PURPOSE: Results of a quality-improvement project to enhance safeguards against "wrong-pen-to-patient" insulin pen errors by permitting secure bedside storage of insulin pens are reported. METHODS: A cluster-randomized controlled evaluation was conducted at an academic medical center to assess adherence with institutional policy on insulin pen storage before and after implementation of a revised policy allowing pen storage in locking boxes in patient rooms. In phase 1 of the study, baseline data on policy adherence were captured for 8 patient care units (4 designated as intervention units and 4 designated as control units)...
December 15, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29222305/biology-of-cns-lymphoma-and-the-potential-of-novel-agents
#14
REVIEW
James L Rubenstein
Primary and secondary CNS lymphomas are aggressive brain tumors that pose an immense challenge to define in terms of molecular pathogenesis, as well as to effectively treat. During the past 10 years improvements in survival have been achieved with the implementation of anti-CD20 immunotherapy and optimization of dose-intensive consolidation strategies. The applications of whole-exome sequencing, comparative genomic hybridization, transcriptional profiling, and examination of the tumor microenvironment, particularly in the context of clinical investigation, provide insights that create a roadmap for the development and implementation of novel targeted agents for this disease...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29222227/pings-phone-based-intervention-under-nurse-guidance-after-stroke-interim-results-of-a-pilot-randomized-controlled-trial
#15
Fred Sarfo, Frank Treiber, Mulugeta Gebregziabher, Sheila Adamu, Sachin Patel, Michelle Nichols, Dominic Awuah, Asumadu Sakyi, Nyantakyi Adu-Darko, Arti Singh, Raelle Tagge, Jenkins Carolyn, Bruce Ovbiagele
BACKGROUND AND PURPOSE: Stroke exacts an immense toll in sub-Saharan Africa where there are few resources, and stroke prevention research is limited. The aim of this study is to test the feasibility and preliminary efficacy of an m-Health technology-enabled, nurse-guided intervention in improving blood pressure (BP) control among Ghanaian stroke patients within 1 month of symptom onset. METHODS: We conducted a 2-arm cluster pilot randomized controlled trial involving 60 recent stroke survivors encountered within a single tertiary medical system in Ghana...
December 8, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29222191/nfs1-expression-protects-lung-tumor-cells-from-ferroptosis
#16
(no author information available yet)
NFS1 activity is essential for maintenance of iron-sulfur cluster biosynthesis in response to oxidative stress.
December 8, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/29221994/allele-and-haplotype-diversity-of-12-x-strs-in-sardinia
#17
C Robino, D Lacerenza, S Aneli, C Di Gaetano, G Matullo, R Robledo, C Calò
The analysis of clusters of tightly linked X-chromosome short tandem repeat (STR) markers can assist the interpretation of complex kinship cases. However, when linkage disequilibrium (LD) is present in the population of origin of tested individuals, haplotype rather than allele frequencies should be used in likelihood calculations. The diversity of twelve X-STRs arranged in four linkage groups (I: DXS10148-DXS10135-DXS8378; II: DXS7132-DXS10079-DXS10074; III: DXS10103-HPRTB-DXS10101; IV: DXS10146-DXS10134-DXS7423) was tested in a Sardinian population sample (n=516) including three open populations from the Northern, Central and Southern part of the island, and three isolates (Benetutti, Desulo, Carloforte)...
December 5, 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/29221965/diffusion-kurtosis-imaging-of-a-human-nasopharyngeal-carcinoma-xenograft-model-initial-experience-with-pathological-correlation
#18
Jing Zhong, Peng Shi, Yunbin Chen, Rongfang Huang, Youping Xiao, Xiang Zheng, Dechun Zheng, Li Peng
PURPOSE: The aim of this study was to investigate the relationship between diffusion kurtosis imaging (DKI)-related parameters and pathological measures using human nasopharyngeal carcinoma (NPC) xenografts in a nude mouse model. MATERIALS AND METHODS: Twenty-six BALB/c-nu nude mice were divided into two groups that were injected with two different nasopharyngeal squamous cell carcinoma cell lines (CNE1 and CNE2). DK magnetic resonance (MR) imaging was performed on a 3...
December 5, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29221897/comparative-mechanical-unfolding-studies-of-spectrin-domains-r15-r16-and-r17
#19
Anna V Glyakina, Ilya V Likhachev, Nikolay K Balabaev, Oxana V Galzitskaya
Spectrins belong to repetitive three-helix bundle proteins that have vital functions in multicellular organisms and are of potential value in nanotechnology. To reveal the unique physical features of repeat proteins we have studied the structural and mechanical properties of three repeats of chicken brain α-spectrin (R15, R16 and R17) at the atomic level under stretching at constant velocities (0.01, 0.05 and 0.1Å·ps-1) and constant forces (700 and900pN) using molecular dynamics (MD) simulations at T = 300K...
December 5, 2017: Journal of Structural Biology
https://www.readbyqxmd.com/read/29221862/physical-activity-sedentary-time-tv-viewing-physical-fitness-and-cardiovascular-disease-risk-in-adolescents-the-helena-study
#20
Alan R Barker, Luis Gracia-Marco, Jonatan R Ruiz, Manuel J Castillo, Raquel Aparicio-Ugarriza, Marcela González-Gross, Anthony Kafatos, Odysseas Androutsos, Angela Polito, Dénes Molnar, Kurt Widhalm, Luis A Moreno
BACKGROUND: To examine the independent associations between physical activity (PA) intensities, sedentary time (ST), TV viewing, cardiorespiratory fitness (CRF) and muscular fitness (MF) with cardiovascular disease (CVD) risk in youth. METHODS: A cross-sectional study on 534 European adolescents (252 males, 282 females, 12.5-17.5years). Minutes per day of light (LPA), moderate (MPA) and vigorous (VPA) PA and total ST were measured using accelerometers. TV viewing time was measured using a questionnaire...
November 26, 2017: International Journal of Cardiology
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