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https://www.readbyqxmd.com/read/28431609/benefit-risk-perception-of-natalizumab-therapy-in-neurologists-and-a-large-cohort-of-multiple-sclerosis-patients
#1
Christoph Heesen, Ingo Kleiter, Sven G Meuth, Julia Krämer, Jürgen Kasper, Sascha Köpke, Wolfgang Gaissmaier
BACKGROUND: Natalizumab (NAT) is associated with the risk of progressive multifocal leukoencephalopathy (PML). Risk stratification algorithms have been developed, however, without detectable reduction of PML incidence. OBJECTIVE: To evaluate to which extent patients and physicians understand and accept risks associated with NAT treatment. METHODS: Prospective observational cohort study in German MS centers (n=73) among NAT-treated MS patients (n=801) and their neurologists (n=99)...
May 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28430482/hopping-time-scales-and-the-phonon-liquid-electron-crystal-picture-in-thermoelectric-copper-selenide
#2
D J Voneshen, H C Walker, K Refson, J P Goff
The suppression of transverse phonons by liquidlike diffusion in superionic conductors has been proposed as a means to dramatically reduce thermal conductivity in thermoelectric materials [H. Lui et al. Nat. Mater. 11, 422 (2012)NMAACR1476-112210.1038/nmat3273]. We have measured the ion transport and lattice dynamics in the original phonon-liquid electron-crystal Cu_{2}Se using neutron spectroscopy. We show that hopping time scales are too slow to significantly affect lattice vibrations and that the transverse phonons persist at all temperatures...
April 7, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28421977/-a-woman-with-pink-urine-and-a-pink-skin
#3
J A Versteeg, G A M van der Nat
A 48-year-old woman with fire-related inhalation injury had pink urine and a pink skin. This was caused by hydroxocobalamin, which was used to treat cyanide poisoning.
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28415295/emergence-of-l%C3%A3-vy-walks-in-systems-of-interacting-individuals
#4
Sergei Fedotov, Nickolay Korabel
We propose a model of superdiffusive Lévy walk as an emergent nonlinear phenomenon in systems of interacting individuals. The aim is to provide a qualitative explanation of recent experiments [G. Ariel et al., Nat. Commun. 6, 8396 (2015)2041-172310.1038/ncomms9396] revealing an intriguing behavior: swarming bacteria fundamentally change their collective motion from simple diffusion into a superdiffusive Lévy walk dynamics. We introduce microscopic mean-field kinetic equations in which we combine two key ingredients: (1) alignment interactions between individuals and (2) non-Markovian effects...
March 2017: Physical Review. E
https://www.readbyqxmd.com/read/28415192/multiple-node-basin-stability-in-complex-dynamical-networks
#5
Chiranjit Mitra, Anshul Choudhary, Sudeshna Sinha, Jürgen Kurths, Reik V Donner
Dynamical entities interacting with each other on complex networks often exhibit multistability. The stability of a desired steady regime (e.g., a synchronized state) to large perturbations is critical in the operation of many real-world networked dynamical systems such as ecosystems, power grids, the human brain, etc. This necessitates the development of appropriate quantifiers of stability of multiple stable states of such systems. Motivated by the concept of basin stability (BS) [P. J. Menck et al., Nat...
March 2017: Physical Review. E
https://www.readbyqxmd.com/read/28409351/inflammation-and-fibrosis-in-polycystic-kidney-disease
#6
Cheng Jack Song, Kurt A Zimmerman, Scott J Henke, Bradley K Yoder
Polycystic kidney disease (PKD) is a commonly inherited disorder characterized by cyst formation and fibrosis (Wilson, N Engl J Med 350:151-164, 2004) and is caused by mutations in cilia or cilia-related proteins, such as polycystin 1 or 2 (Oh and Katsanis, Development 139:443-448, 2012; Kotsis et al., Nephrol Dial Transplant 28:518-526, 2013). A major pathological feature of PKD is the development of interstitial inflammation and fibrosis with an associated accumulation of inflammatory cells (Grantham, N Engl J Med 359:1477-1485, 2008; Zeier et al...
2017: Results and Problems in Cell Differentiation
https://www.readbyqxmd.com/read/28404970/pseudogene-phbp1-promotes-esophageal-squamous-cell-carcinoma-proliferation-by-increasing-its-cognate-gene-phb-expression
#7
Feiyue Feng, Bin Qiu, Ruochuan Zang, Peng Song, Shugeng Gao
Natural antisense transcripts (NATs) as one of the most diverse classes of long noncoding RNAs (lncRNAs), have been demonstrated involved in fundamental biological processes in human. Here, we reported that human prohibitin gene pseudogene 1 (PHBP1) was upregulated in ESCC, and increased PHBP1 expression in ESCC was associated with clinical advanced stage. Functional experiments showed that PHBP1 knockdown inhibited ESCC cells proliferation, colony formation and xenograft tumor growth in vitro and in vivo by causing cell-cycle arrest at the G1-G0 phase...
March 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28403831/the-role-of-tre6p-and-snrk1-in-maize-early-kernel-development-and-events-leading-to-stress-induced-kernel-abortion
#8
Samuel W Bledsoe, Clémence Henry, Cara A Griffiths, Matthew J Paul, Regina Feil, John E Lunn, Mark Stitt, L Mark Lagrimini
BACKGROUND: Drought stress during flowering is a major contributor to yield loss in maize. Genetic and biotechnological improvement in yield sustainability requires an understanding of the mechanisms underpinning yield loss. Sucrose starvation has been proposed as the cause for kernel abortion; however, potential targets for genetic improvement have not been identified. Field and greenhouse drought studies with maize are expensive and it can be difficult to reproduce results; therefore, an in vitro kernel culture method is presented as a proxy for drought stress occurring at the time of flowering in maize (3 days after pollination)...
April 12, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28398958/new-onset-diabetes-in-hiv-treated-adults-from-thailand-predictors-long-term-renal-and-cardiovascular-outcomes
#9
Opass Putcharoen, Lalita Wattanachanya, Jiratchaya Sophonphan, Sarawut Siwamogsatham, Vorapot Sapsirisavat, Sivaporn Gatechompol, Supalak Phonphithak, Stephen J Kerr, Yingyos Avihingsanon, Kiat Ruxrungtham, Anchalee Avihingsanon
OBJECTIVE: To determine the incidence and risk factors for developing diabetes mellitus (DM) in a cohort of Thai HIV-infected patients on long-term combination antiretroviral therapy (cART). DESIGN: Prospective study conducted between July 1996-April 30, 2015. METHODS: 1,748 subjects (60% males) who did not have DM prior to ART were assessed twice a year. Incident DM was defined as either having two consecutive fasting glucose levels >126 mg/dL, or reporting anti-DM medication/ DM diagnosis after starting cART...
April 10, 2017: AIDS
https://www.readbyqxmd.com/read/28396218/analysis-of-clinical-and-ultrasound-determinants-of-adnexal-torsion-in-children-and-adolescents
#10
Rebecca Jourjon, Baptiste Morel, Sabine Irtan, Etienne Audureau, Aurore Coulomb-L'Herminé, Michèle Larroquet, Hubert Ducou le Pointe, Eléonore Blondiaux
STUDY OBJECTIVE: We aimed to assess the performance of transabdominal ultrasonography (US) for diagnosis of adnexal torsion (AT) in girls and adolescents and evaluate its clinical and US determinants. STUDY DESIGN, PARTICIPANTS, INTERVENTIONS AND OUTCOME MEASURES: We retrospectively (2004 to 2014) studied data for girls referred for acute or sub-acute pelvic pain who underwent US and included girls 3 months to 18 years old who underwent surgical exploration and/or clinical and radiological follow-up for at least 3 months...
April 7, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28390356/brownian-dynamics-of-confined-suspensions-of-active-microrollers
#11
Florencio Balboa Usabiaga, Blaise Delmotte, Aleksandar Donev
We develop efficient numerical methods for performing many-body Brownian dynamics simulations of a recently observed fingering instability in an active suspension of colloidal rollers sedimented above a wall [M. Driscoll, B. Delmotte, M. Youssef, S. Sacanna, A. Donev, and P. Chaikin, Nat. Phys. (2016), preprint arXiv:1609.08673. We present a stochastic Adams-Bashforth integrator for the equations of Brownian dynamics, which has the same cost but is more accurate than the widely used Euler-Maruyama scheme, and use a random finite difference to capture the stochastic drift proportional to the divergence of the configuration-dependent mobility matrix...
April 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28389206/residual-risk-of-hiv-hcv-and-hbv-in-canada
#12
Sheila F O'Brien, Qi-Long Yi, Wenli Fan, Vito Scalia, Mindy Goldman, Margaret A Fearon
BACKGROUND: Residual risk is estimated as the product of the incidence and the infectious window period, the time during which a blood donation could be infectious but the assay may not detect it. In 2011 nucleic acid multiplex testing (MPX) was implemented in 6 unit minipools (previously 24 unit minipools). MPX also included hepatitis B (HBV) NAT for the first time (complementing HBsAg screening) in addition to HIV-1 and hepatitis C (HCV) as before. We aimed to estimate window period risk-day equivalents for MPX, and the residual risk of viral infections in blood donations updated to reflect current incidence and testing...
March 18, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28387539/expression-of-phosphorylated-hippo-pathway-kinases-mst1-2-and-lats1-2-in-her2-positive-and-triple-negative-breast-cancer-patients-treated-with-neoadjuvant-therapy
#13
Cristiana Ercolani, Anna Di Benedetto, Irene Terrenato, Laura Pizzuti, Luigi Di Lauro, Domenico Sergi, Francesca Sperati, Simonetta Buglioni, Maria Teresa Ramieri, Lucia Mentuccia, Teresa Gamucci, Letizia Perracchio, Edoardo Pescarmona, Marcella Mottolese, Maddalena Barba, Patrizia Vici, Ruggero De Maria, Marcello Maugeri-Saccà
The Hippo kinases MST1/2 and LATS1/2 inhibit the oncoproteins TAZ/YAP and regulate T cell function. Hippo kinases also cooperate with the ATR-Chk1 and ATM-Chk2 pathways, central orchestrators of the DNA damage response (DDR). We hypothesized that MST1/2 and LATS1/2 localization differently impacts the efficacy of neoadjuvant therapy (NAT) in breast cancer, being protective when expressed in the cytoplasm of tumor cells and in tumor-infiltrating lymphocytes, whereas representing molecular determinants of chemoresistance when present in the nucleus as a consequence of their cooperation with the DDR...
April 7, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/28387315/genome-wide-identification-and-functional-prediction-of-cold-and-or-drought-responsive-lncrnas-in-cassava
#14
Shuxia Li, Xiang Yu, Ning Lei, Zhihao Cheng, Pingjuan Zhao, Yuke He, Wenquan Wang, Ming Peng
Cold and drought stresses seriously affect cassava (Manihot esculenta) plant growth and yield. Recently, long noncoding RNAs (lncRNAs) have emerged as key regulators of diverse cellular processes in mammals and plants. To date, no systematic screening of lncRNAs under abiotic stress and their regulatory roles in cassava has been reported. In this study, we present the first reference catalog of 682 high-confidence lncRNAs based on analysis of strand-specific RNA-seq data from cassava shoot apices and young leaves under cold, drought stress and control conditions...
April 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28386744/impact-of-chronic-kidney-disease-among-korean-adults-with-chronic-obstructive-pulmonary-disease
#15
Min Young Kim, Sungmin Boo, Mijung Yoo, Jonghyun Lee, Na Ree Kang
PURPOSE: Chronic kidney disease (CKD) is an emerging issue in patients with chronic obstructive pulmonary disease (COPD). In COPD, loss of muscle mass is relatively common finding, and diagnosis of CKD should be based on measured or estimated GFR (Cavailles et al. Eur Respir Rev 22:454-475, 2013; Gosker et al. Am J Clin Nutr 71:1033-1047, 2000; Delanaye and Mariat Nat Rev Nephrol 9:513-522, 2013). We aimed to determine the prevalence and impact of CKD, defined by using chronic kidney disease epidemiology collaboration (CKD-EPI) equation, in COPD patients...
April 6, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28382947/negative-differential-resistance-and-bias-modulated-metal-to-insulator-transition-in-zigzag-c2n-h2d-nanoribbon
#16
Jing-Jing He, Yan-Dong Guo, Xiao-Hong Yan
Motivated by the fabrication of layered two-dimensional material C2N-h2D [Nat. Commun. 6, 6486 (2015)], we cut the single-layer C2N-h2D into a zigzag nanoribbon and perform a theoretical study. The results indicate that the band structure changes from semiconducting to metallic and a negative differential resistance effect occurs in the I-V curve. Interestingly, the current can be reduced to zero and this insulator-like state can be maintained as the bias increases. We find this unique property is originated from a peculiar band morphology, with only two subbands appearing around the Fermi level while others being far away...
April 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28382154/analysis-of-origin-and-protein-protein-interaction-maps-suggests-distinct-oncogenic-role-of-nuclear-egfr-during-cancer-evolution
#17
Ainur Sharip, Diyora Abdukhakimova, Xiao Wang, Alexey Kim, Yevgeniy Kim, Aigul Sharip, Askarbek Orakov, Lixia Miao, Qinglei Sun, Yue Chen, Zhenbang Chen, Yingqiu Xie
Receptor tyrosine kinase EGFR usually is localized on plasma membrane to induce progression of many cancers including cancers in children (Bodey et al. In Vivo. 2005, 19:931-41), but it contains a nuclear localization signal (NLS) that mediates EGFR nuclear translocation (Lin et al. Nat Cell Biol. 2001, 3:802-8). Here we report that NLS of EGFR has its old evolutionary origin. Protein-protein interaction maps suggests that nEGFR pathways are different from membrane EGFR and EGF is not found in nEGFR network while androgen receptor (AR) is found, which suggests the evolution of prostate cancer, a well-known AR driven cancer, through changes in androgen- or EGF-dependence...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28380908/tunable-nanophotonic-array-traps-with-enhanced-force-and-stability
#18
Fan Ye, Mohammad Soltani, James T Inman, Michelle D Wang
A nanophotonic trapping platform based on on-chip tunable optical interference allows parallel processing of biomolecules and holds promise to make single molecule manipulation and precision measurements more easily and broadly available. The nanophotonic standing wave array trap (nSWAT) device [Nat. Nanotechnol. 9, 448 (2014); Nano Lett. 16, 6661 (2016)] represents such a platform and can trap a large array of beads by the evanescent field of the standing wave of a nanophotonic waveguide and reposition them using an integrated microheater...
April 3, 2017: Optics Express
https://www.readbyqxmd.com/read/28370177/blood-safety-implications-of-donors-using-hiv-pre-exposure-prophylaxis
#19
C R Seed, H Yang, J F Lee
HIV pre-exposure prophylaxis (PrEP) is the use of one or more antiretroviral medications (in combination) to prevent HIV infection. The most commonly used PrEP medication (Truvada(®) , Gilead Sciences, Inc.) acts by inhibiting HIV-1 reverse transcriptase. If someone who is using PrEP unknowingly becomes HIV infected (termed 'PrEP breakthrough infection'), there may be suppressed viral replication resulting in a virus level undetectable by the most sensitive HIV NAT. Failure to seroconvert and seroreversion (loss of previously detectable HIV antibodies) have also both been observed with 2nd, 3rd and 4th generation screening immunoassays, as well as Western blot assays...
March 31, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28361317/generation-of-gastrointestinal-organoids-from-human-pluripotent-stem-cells
#20
Jorge O Múnera, James M Wells
Over the past several decades, developmental biologists have discovered fundamental mechanisms by which organs form in developing embryos. With this information it is now possible to generate human "organoids" by the stepwise differentiation of human pluripotent stem cells using a process that recapitulates organ development. For the gastrointestinal tract, one of the first key steps is the formation of definitive endoderm and mesoderm, a process that relies on the TGFb molecule Nodal. Endoderm is then patterned along the anterior-posterior axis, with anterior endoderm forming the foregut and posterior endoderm forming the mid and hindgut...
2017: Methods in Molecular Biology
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