keyword
MENU ▼
Read by QxMD icon Read
search

NAT

keyword
https://www.readbyqxmd.com/read/29776654/defining-and-measuring-a-standard-set-of-patient-relevant-outcomes-in-coronary-artery-disease
#1
Edgar J Daeter, Marijke J C Timmermans, Alexander Hirsch, Eric Lipsic, Saskia Houterman, Dennis van Veghel, Paul B van der Nat
Systematic outcome measurement enables to continuously improve treatment results and stimulates dissemination of best practices. For patients with coronary artery disease, no examples yet exist of standard sets of patient-relevant outcome measures that have already been fully implemented at a large scale in clinical care. The aim of this paper is twofold: (1) to share the standard set of outcome measures as developed by Meetbaar Beter, and (2) to show how the standard set is presented and published to support improvement of cardiac care...
April 20, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29776027/tensor-network-method-for-reversible-classical-computation
#2
Zhi-Cheng Yang, Stefanos Kourtis, Claudio Chamon, Eduardo R Mucciolo, Andrei E Ruckenstein
We develop a tensor network technique that can solve universal reversible classical computational problems, formulated as vertex models on a square lattice [Nat. Commun. 8, 15303 (2017)2041-172310.1038/ncomms15303]. By encoding the truth table of each vertex constraint in a tensor, the total number of solutions compatible with partial inputs and outputs at the boundary can be represented as the full contraction of a tensor network. We introduce an iterative compression-decimation (ICD) scheme that performs this contraction efficiently...
March 2018: Physical Review. E
https://www.readbyqxmd.com/read/29775919/effectiveness-of-a-flow-based-device-using-riboflavin-photochemistry-in-damaging-blood-borne-viral-nucleic-acids
#3
Liguo Zhu, Hongli Tong, Shufang Wang, Yang Yu, Zhong Liu, Changqing Li, Deqing Wang
BACKGROUND: Effectiveness of a flow-based treatment device using riboflavin photochemistry was demonstrated by cytopathic effect method using indicator viruses. However, inactivation efficacy against real blood-borne viruses needs to be evaluated, especially at nucleic acid level. MATERIAL AND METHODS: Special plasma samples with varying concentrations of blood-borne virus were selected using a strict blood selection procedure and were treated with device treatment (DT)...
May 3, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29771771/a-therapeutic-strategy-for-resectable-pancreatic-cancer-based-on-risk-factors-of-early-recurrence
#4
Hiroshi Kurahara, Kosei Maemura, Yuko Mataki, Masahiko Sakoda, Satoshi Iino, Yota Kawasaki, Takaaki Arigami, Shinichiro Mori, Yuko Kijima, Shinichi Ueno, Hiroyuki Shinchi, Shoji Natsugoe
OBJECTIVES: The aim of this study was to identify risk factors for early recurrence and assess the prognostic benefit of neoadjuvant therapy (NAT) for resectable pancreatic cancer. METHODS: Patients with radiographically resectable pancreatic cancer according to the National Comprehensive Cancer Network guidelines were enrolled. We regarded recurrence within 6 months after surgery as early recurrence. RESULTS: This study involved 115 patients (80 who underwent upfront surgery and 35 who received NAT)...
May 15, 2018: Pancreas
https://www.readbyqxmd.com/read/29770209/cell-specific-cis-natural-antisense-transcripts-cis-nats-in-the-sperm-and-the-pollen-vegetative-cells-of-arabidopsis-thaliana
#5
Peng Qin, Ann E Loraine, Sheila McCormick
Background: cis-NATs ( cis-natural antisense transcripts ) are transcribed from opposite strands of adjacent genes and have been shown to regulate gene expression by generating small RNAs from the overlapping region. cis-NATs are important for plant development and resistance to pathogens and stress. Several genome-wide investigations identified a number of cis-NAT pairs, but these investigations predicted cis-NATS using expression data from bulk samples that included lots of cell types. Some cis-NAT pairs identified from those investigations might not be functional, because both transcripts of cis-NAT pairs need to be co-expressed in the same cell...
2018: F1000Research
https://www.readbyqxmd.com/read/29768691/detection-of-hepatitis-b-virus-dna-among-chronic-and-potential-occult-hbv-patients-in-resource-limited-settings-by-loop-mediated-isothermal-amplification-assay
#6
Arifa Akram, S M Rashedul Islam, Saif Ullah Munshi, Shahina Tabassum
Transmission of Hepatitis B Virus (HBV) usually occurs due to the transfusion of blood or blood products from chronic HBV (CHB) or occult HBV infected (OBI) patients. Besides serological tests e.g. HBsAg and anti-HBc (total), detection of HBV-DNA is necessary for the diagnosis of OBI patients. Different nucleic acid tests (NATs) including real-time-Polymerase Chain Reaction (qPCR) are used for the detect HBV-DNA. The NATs are expensive and require technical expertise which are barriers to introducing them in resource-limited settings...
May 16, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29767761/significance-of-hbv-nat-among-hbs-antigen-negative-blood-donors-in-saudi-arabia
#7
Nessrin Ghazi Alabdallat, Abdul Aziz A Bin Dukhyil
Background: Bloodborne hepatitis B virus (HBV) transmission from asymptomatic donors with acute HBV infections who have undetectable surface antigen of HBV (HBsAg), or from donors with chronic infections in whom serological markers were not detected, could cause residual infections leading to relevant transfusion-transmitted infections (RTTIs). HBV nucleic acid testing (NAT) can detect HBV DNA in the HBsAg-negative and total hepatitis B core antibody (anti-HBc)-negative window period of infection and in chronic cases...
May 15, 2018: Laboratory Medicine
https://www.readbyqxmd.com/read/29761390/isolation-and-phenotyping-of-bone-marrow-macrophages
#8
Marion Chalot
Macrophages are present in most of the tissues in the organism. They are basically separated into two categories: the resident macrophages, specific of the tissue and capable of proliferation, and the macrophages deriving from the monocyte differentiation. In the bone marrow, the "resident" macrophages are part of the hematopoietic stem cell niche.Those macrophages are known to have a role in the support of erythropoiesis (Chow, Nat Med 19:429-436, 2013), the maintenance of stem cell in their niches (Chow, J Exp Med 208:261-271, 2011), and are an independent self-renewing population (Hashimoto, Immunity 38:792-804, 2013)...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29761331/folfirinox-versus-gemcitabine-nab-paclitaxel-for-neoadjuvant-treatment-of-resectable-and-borderline-resectable-pancreatic-head-adenocarcinoma
#9
Mashaal Dhir, Mazen S Zenati, Ahmad Hamad, Aatur D Singhi, Nathan Bahary, Melissa E Hogg, Herbert J Zeh, Amer H Zureikat
BACKGROUND: Both FOLFIRINOX and gemcitabine/nab-paclitaxel (G-nP) are used increasingly in the neoadjuvant treatment (NAT) of pancreatic ductal adenocarcinoma (PDA). This study aimed to compare neoadjuvant FOLFIRINOX and G-nP in the treatment of resectable (R) and borderline resectable (BR) head PDA. METHODS: A single-institution retrospective review of R and BR patients undergoing pancreaticoduodenectomy after NAT with FOLFIRINOX or G-nP was performed. Comparative analysis was performed using inverse-probability-weighted (IPW) estimators...
May 14, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29758749/role-of-atomic-spin-mechanical-coupling-in-the-problem-of-a-magnetic-biocompass
#10
Yunshan Cao, Peng Yan
It is a well established notion that animals can detect the Earth's magnetic field, while the biophysical origin of such magnetoreception is still elusive. Recently, a magnetic receptor Drosophila CG8198 (MagR) with a rodlike protein complex is reported [S. Qin et al., Nat. Mater. 15, 217 (2016)10.1038/nmat4484] to act like a compass needle to guide the magnetic orientation of animals. This view, however, is challenged [M. Meister, Elife 5, e17210 (2016)10.7554/eLife.17210] by arguing that thermal fluctuations beat the Zeeman coupling of the proteins's magnetic moment with the rather weak geomagnetic field (∼25-65 μT)...
April 2018: Physical Review. E
https://www.readbyqxmd.com/read/29756881/light-induced-type-ii-band-inversion-and-quantum-anomalous-hall-state-in-monolayer-fese
#11
Z F Wang, Zhao Liu, Jinlong Yang, Feng Liu
Coupling a quantum anomalous Hall (QAH) state with a superconducting state offers an attractive approach to detect the signature alluding to a topological superconducting state [Q. L. He et al., Science 357, 294 (2017)SCIEAS0036-807510.1126/science.aag2792], but its explanation could be clouded by disorder effects in magnetic doped QAH materials. On the other hand, an antiferromagnetic (AFM) quantum spin Hall (QSH) state is identified in the well-known high-temperature 2D superconductor of monolayer FeSe [Z...
April 13, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29756880/ultrastrong-coupling-few-photon-scattering-theory
#12
Tao Shi, Yue Chang, Juan José García-Ripoll
We study the scattering of individual photons by a two-level system ultrastrongly coupled to a waveguide. The scattering is elastic for a broad range of couplings and can be described with an effective U(1)-symmetric Hamiltonian. This simple model allows the prediction of scattering resonance line shapes, validated up to α=0.3, and close to the Toulouse point α=1/2, where inelastic scattering becomes relevant. Our predictions model experiments with superconducting circuits [P. Forn-Díaz et al., Nat. Phys...
April 13, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29756024/preparation-and-preclinical-evaluation-of-a-68-ga-labelled-c-rgdfk-conjugate-comprising-the-bifunctional-chelator-nodia-me
#13
Tilman Läppchen, Jason P Holland, Yvonne Kiefer, Mark D Bartholomä
Background: We recently developed a chelating platform based on the macrocycle 1,4,7-triazacyclononane with up to three, five-membered azaheterocyclic arms for the development of 68 Ga- and 64 Cu-based radiopharmaceuticals. Here, a 68 Ga-labelled conjugate comprising the bifunctional chelator NODIA-Me in combination with the αv ß3 -targeting peptide c(RGDfK) has been synthesized and characterized. The primary aim was to evaluate further the potential of our NODIA-Me chelating system for the development of 68 Ga-labelled radiotracers...
2018: EJNMMI Radiopharmacy and Chemistry
https://www.readbyqxmd.com/read/29756007/mapping-disulfide-bonds-from-sub-micrograms-of-purified-proteins-or-micrograms-of-complex-protein-mixtures
#14
Shan Lu, Yong Cao, Sheng-Bo Fan, Zhen-Lin Chen, Run-Qian Fang, Si-Min He, Meng-Qiu Dong
Disulfide bonds are vital for protein functions, but locating the linkage sites has been a challenge in protein chemistry, especially when the quantity of a sample is small or the complexity is high. In 2015, our laboratory developed a sensitive and efficient method for mapping protein disulfide bonds from simple or complex samples (Lu et al . in Nat Methods 12:329, 2015). This method is based on liquid chromatography-mass spectrometry (LC-MS) and a powerful data analysis software tool named pLink. To facilitate application of this method, we present step-by-step disulfide mapping protocols for three types of samples-purified proteins in solution, proteins in SDS-PAGE gels, and complex protein mixtures in solution...
2018: Biophysics Reports
https://www.readbyqxmd.com/read/29754825/structure-of-human-nata-and-its-regulation-by-the-huntingtin-interacting-protein-hypk
#15
Leah Gottlieb, Ronen Marmorstein
Co-translational N-terminal protein acetylation regulates many protein functions including degradation, folding, interprotein interactions, and targeting. Human NatA (hNatA), one of six conserved metazoan N-terminal acetyltransferases, contains Naa10 catalytic and Naa15 auxiliary subunits, and associates with the intrinsically disordered Huntingtin yeast two-hybrid protein K (HYPK). We report on the crystal structures of hNatA and hNatA/HYPK, and associated biochemical and enzymatic analyses. We demonstrate that hNatA contains unique features: a stabilizing inositol hexaphosphate (IP6 ) molecule and a metazoan-specific Naa15 domain that mediates high-affinity HYPK binding...
April 23, 2018: Structure
https://www.readbyqxmd.com/read/29753589/development-of-a-highly-sensitive-pcr-dna-chip-method-to-detect-mycoplasmas-in-a-veterinary-modified-live-vaccine
#16
Sylvie Mbelo, Virginie Gay, Stephanie Blanchard, Eric Abachin, Stephanie Falque, Jacques Lechenet, Hervé Poulet, Blandine de Saint-Vis
Mycoplasmas are potential contaminants that introduce undesirable changes in mammalian cell cultures. They frequently contaminate cell substrates and other starting materials used for manufacturing cell-derived biologics, such as vaccines and pharmaceutical products. Mycoplasma purity testing of live vaccines, active ingredients, raw material, and seed lots is required during vaccine production. Previously, testing using a time-consuming, costly 28-day culture assay, which lacks sensitivity for species that do not grow in culture, was required in the European Pharmacopoeia (Ph...
May 9, 2018: Biologicals: Journal of the International Association of Biological Standardization
https://www.readbyqxmd.com/read/29751076/tobacco-specific-nitrosamines-a-literature-review
#17
Evangelia Konstantinou, Foteini Fotopoulou, Athanasios Drosos, Nektaria Dimakopoulou, Zoi Zagoriti, Athanasios Niarchos, Dimitra Makrynioti, Dimitrios Kouretas, George Lagoumintzis, Konstantinos Poulas
Cigarette smoke is a complex mixture of chemicals, including several tobacco-specific nitrosamines (TSNA). Most TSNA are formed in tobacco during the post-harvest period, while a number are produced when a cigarette is burned. Considerable evidence supports the role of TSNA important causative factors for cancers of the lung, pancreas, esophagus, and oral cavity in people who use tobacco products. Of the known TSNA, nicotine-derived nitrosamine ketone (NNK) and N-nitrosonornicotine (NNN) are the most carcinogenic...
May 8, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29750451/in-memoriam-professor-dr-rer-nat-bj%C3%A3-rn-manfred-hausen-geboren-am-11-10-1940-in-gotenhafen-westpreu%C3%A3-en-gestorben-am-14-12-2017-in-stade
#18
Johannes Geier, Andreas Kleinheinz
No abstract text is available yet for this article.
May 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29750101/evaluation-of-the-erosive-capacity-of-children-s-beverages-on-primary-teeth-enamel-an-in-vitro-study
#19
Daniel-Gheur Tocolini, Mariana Dalledone, João-Armando Brancher, Juliana-Feltrin de Souza, Carla-Castiglia Gonzaga
Background: The consumption of acidified beverages, associated with lower mineralization of primary enamel, is the ideal combination for the development and progression of dental erosion. The objective of this study is to analyze the erosive capacity and the surface roughness of primary teeth enamel after exposure to three different brands of grape juices. Material and Methods: Forty enamel blocks of primary teeth were obtained, attened and polished. They were submitted to initial surface roughness analysis (baseline), and randomly assigned into four groups (n = 10): NAT: natural grape juice (Campo Largo); IND: industrialized grape juice (Dell Vale Kapo); SOY: soy-based grape juice (Ades); and CONT (control): artificial saliva...
April 2018: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29749406/improvement-of-the-activity-of-the-anti-hiv-1-integrase-aptamer-t30175-by-introducing-a-modified-thymidine-into-the-loops
#20
Antonella Virgilio, Teresa Amato, Luigi Petraccone, Francesca Esposito, Nicole Grandi, Enzo Tramontano, Raquel Romero, Shozeb Haider, Isabel Gomez-Monterrey, Ettore Novellino, Luciano Mayol, Veronica Esposito, Aldo Galeone
In this paper, we report our investigations on analogues of the anti-human immunodeficiency virus type 1 (HIV-1) integrase (IN) aptamer T30175 in which the individual thymidines forming the loops were replaced by 5-hydroxymethyl-2'-deoxyuridine residues (H). Circular dichroism, nuclear magnetic resonance and gel electrophoresis investigations clearly indicated that all the modified aptamers preserve the ability to form the original 5'-5' end-stacked head-to-head dimeric G-quadruplex structure, in which each G-quadruplex adopts a parallel arrangement and is characterized by three G-tetrads, three propeller loops and one bulge-loop...
May 10, 2018: Scientific Reports
keyword
keyword
3184
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"