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https://www.readbyqxmd.com/read/28929772/bismuth-oxychalocogenides-a-new-class-of-ferroelectric-ferroelastic-materials-with-ultra-high-mobility
#1
Menghao Wu, Xiao Cheng Zeng
Atomically thin Bi2O2Se has been recently synthesized and it possesses ultra-high mobility (Nat Nanotech. 2017, 12, 530; Nano Lett. 2017, 17, 3021). Herein, we show first-principles evidence that Bi2O2Se and a related class of bismuth oxychalcogenides, such as Bi2O2S and Bi2O2Te, not only are novel semiconductors with ultra-high mobility but also possesses previously unreported ferroelectricity/ferroelasticity. Such a unique combination of semiconducting with ferroelectric/ferroelastic properties enables bismuth oxychalcogenides to potentially meet a great challenge, that is, integration of room-temperature functional non-volatile memories into future nanocircuits...
September 20, 2017: Nano Letters
https://www.readbyqxmd.com/read/28927802/synthesis-and-biological-evaluation-of-an-111-in-labeled-exendin-4-derivative-as-a-single-photon-emission-computed-tomography-probe-for-imaging-pancreatic-%C3%AE-cells
#2
Hiroyuki Kimura, Naotaka Fujita, Kaori Kanbe, Hirokazu Matsuda, Hiroyuki Watanabe, Kenji Arimitsu, Hiroyuki Fujimoto, Keita Hamamatsu, Yusuke Yagi, Masahiro Ono, Nobuya Inagaki, Hideo Saji
A non-invasive method of pancreatic β-cell mass measurement is needed to enhance our understanding of the pathogenesis of diabetes, facilitate the early diagnosis of this disease, and promote the development of novel therapeutics. Here, we described the synthesis of a novel indium-111 ((111)In) exendin-4 derivative, [Lys(12)(In-BnDTPA-Ahx)]exendin-4, through a process involving isothiocyanate-benzyl-DTPA (BnDTPA) and 6-aminohexanoic acid (Ahx) attached to an ɛ-amino group at the lysine-12 residue. We further evaluated the potential use of this derivative as a SPECT probe for pancreatic β-cell imaging...
September 7, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28926487/the-frequency-of-nonaccidental-trauma-in-children-under-the-age-of-3-years-with-femur-fractures-is-there-a-better-cutoff-point-for-universal-workups
#3
Jochen P Son-Hing, Z Deniz Olgun
The purpose of this study was to evaluate narrower age groups in children aged 0-4 years to determine whether guidelines should be refined when investigating femur fractures for nonaccidental trauma (NAT). This was a retrospective review of the pediatric trauma database at our level 1 pediatric trauma center. The database was examined from 2009 to present. We examined rates of NAT in the less than or equal to 12-month, 13-24-month, 25-36-month, and 37-48-month age groups. χ was used to compare rates of NAT between these groups, and P less than 0...
September 18, 2017: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/28922335/the-role-of-68ga-psma-i-t-pet-ct-in-the-pretreatment-staging-of-primary-prostate-cancer
#4
Danielle P Meyrick, Marcus Asokendaran, Laura A Skelly, Nat P Lenzo, Andrew Henderson
OBJECTIVES: This retrospective study aimed to evaluate the role of Ga-PSMA-I&T PET/CT in the primary staging of newly diagnosed prostate cancer (PCa), with a focus on the detection of metastatic nodal disease. Correlation of the rate of detection of metastatic disease by Ga-PSMA-I&T PET/CT with the Gleason score (GS) and serum prostate-specific antigen (PSA) was performed to determine the GS and PSA criteria defining patients who would benefit from Ga-PSMA-I&T PET/CT imaging for staging, risk stratification and therapy optimization...
September 15, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28916118/benefit-of-combination-chemotherapy-and-radiation-stratified-by-grade-of-stage-iiic-endometrial-cancer
#5
Pratibha S Binder, Lindsay M Kuroki, Peinan Zhao, Sarah Cusworth, Laura M Divine, Andrea R Hagemann, Carolyn K McCourt, Premal H Thaker, Matthew A Powell, David G Mutch, L Stewart Massad
OBJECTIVE: The optimal strategy for adjuvant therapy in stage IIIC endometrial cancer has not been determined. Our aim was to evaluate survival benefit of different treatments and to investigate if benefit varied by histologic grade. METHODS: We identified 199 patients with stage IIIC endometrial cancer from 2000 to 2012 through the Siteman Cancer Center registry. All patients underwent surgical staging followed by no adjuvant therapy (NAT), radiation (RT), chemotherapy (CT) or chemoradiation (CRT)...
September 12, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28914697/are-we-ready-to-treat-hepatitis-c-virus-in-individuals-with-opioid-use-disorder-assessment-of-readiness-in-european-countries-on-the-basis-of-an-expert-generated-model
#6
Nat Wright, Jens Reimer, Lorenzo Somaini, Carlos Roncero, Icro Maremmani, Nicolas Simon, Peter Krajci, Richard Littlewood, Oscar D'Agnone, Hannu Alho, Benjamin Rolland
Individuals with a history of injecting drugs have a high prevalence of chronic hepatitis C (HCV) infection. Many have a history of opioid use disorder (OUD). Despite novel treatments with improved efficacy and tolerability, treatment is limited in the group. A faculty of experts shared insights from clinical practice to develop an HCV care-readiness model. Evidence and expert knowledge was collected. Ten experts developed a model of three factors (with measures): 'healthcare engagement', 'guidance' and 'place'...
September 13, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28912933/a-model-approach-to-public-engagement-training-for-students-in-developing-countries
#7
Thomas K Karikari, Nat Ato Yawson
No abstract text is available yet for this article.
2017: Journal of Microbiology & Biology Education: JMBE
https://www.readbyqxmd.com/read/28905475/evaluation-of-volumetric-dimensional-changes-in-posterior-extraction-sites-with-and-without-arp-using-a-novel-imaging-device
#8
Carolina Sbordone, Paolo Toti, Ranieri Martuscelli, Franco Guidetti, Massimo Porzio, Ludovico Sbordone
BACKGROUND: Alveolar ridge volume loss may be minimized when postextraction sockets are filled by bone substitutes. PURPOSE: The aim of the study was to measure the effect of alveolar ridge preservation (ARP) in maintaining the external contour of the ridge after fresh socket grafting with or without particulate anorganic bovine bone mineral (BBM) and resorbable barrier covering. MATERIALS AND METHODS: In the present controlled study, patients subjected to single-tooth extraction were allocated to 2 groups: postextraction sockets grafted with bovine bone mineral (bbm), and naturally healing sockets (nat)...
September 14, 2017: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/28903754/supporting-research-readiness-in-social-enterprise-health-services
#9
EDITORIAL
Nat M J Wright, Philippa Hearty, Linda Harris, Andrew Burnell, Sue Pender, Chris Oxnard, George Charlesworth
Health-based social enterprises are spun out of the NHS, yet continue to provide NHS-funded services. With the spin-out, however, formal processes for research governance were lost. Patients have a right to take part in research, regardless of where they access healthcare. This paper discusses the barriers to social enterprises undertaking applied health research and makes recommendations to address the need for equivalence of governance processes with NHS trusts.
September 13, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28903500/intrinsic-xenobiotic-metabolizing-enzyme-activities-in-early-life-stages-of-zebrafish-danio-rerio
#10
Jens C Otte, Bernadette Schultz, Daniela Fruth, Eric Fabian, Bennard van Ravenzwaay, Björn Hidding, Edward R Salinas
Early life stages of zebrafish (Danio rerio, zf) are gaining attention as an alternative invivo test system for drug discovery, early developmental toxicity screenings and chemical testing in ecotoxicological and toxicological testing strategies. Previous studies have demonstrated transcriptional evidence for xenobiotic metabolizing enzymes (XME) during early zf development. However, elaborate experiments on XME activities during development are incomplete. In this work, the intrinsic activities of representative phase I and II XME were monitored by transformation of putative zf model substrates analyzed using photometry and high pressure liquid chromatography techniques...
September 1, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28903025/experimental-neospora-caninum-infection-in-chickens-gallus-gallus-domesticus-with-oocysts-and-tachyzoites-of-two-recent-isolates-reveals-resistance-to-infection
#11
Solange Oliveira, Juliana Aizawa, Herbert Sousa Soares, Daniela Pontes Chiebao, Márcio Botelho de Castro, Aline S Hora, Marcos Gomes Lopes, Gereon Schares, Mark C Jenkins, Oliver C H Kwok, Ricardo Augusto Dias, Solange Maria Gennari, Jitender P Dubey, Hilda Fátima Jesus Pena
The importance of birds in the biological cycle of Neospora caninum is not clear. We report unsuccessful Neospora infection in chickens (Gallus gallus domesticus) using two isolates of N. caninum. In experiment #1, 30 White Leghorn chickens were orally inoculated with viable N. caninum oocysts (NC-SP1 isolate, 200 oocysts per bird) via the crop at 21 days of age. Groups of three birds were euthanized at intervals of 7 days (a total of 9 weeks) and one group was challenged with the same oocyst dose at 37 days p...
September 10, 2017: International Journal for Parasitology
https://www.readbyqxmd.com/read/28895300/exsta-external-standard-addition-method-for-accurate-high-throughput-quantitation-in-targeted-proteomics-experiments
#12
Yassene Mohammed, Jingxi Pan, Suping Zhang, Jun Han, Christoph H Borchers
PURPOSE: Targeted proteomics using multiple reaction monitoring (MRM) with stable-isotope-labeled internal-standard (SIS) peptides is the current method of choice for protein quantitation in complex biological matrices. Better quantitation can be achieved with the internal standard-addition method, where successive increments of synthesized natural form (NAT) of the endogenous analyte are added to each sample, a response curve is generated, and the endogenous concentration is determined at the x-intercept...
September 11, 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/28893469/-68-ga-labeled-erlotinib-a-novel-pet-probe-for-imaging-egfr-over-expressing-tumors
#13
Akanksha Jain, Mythili Kameswaran, Usha Pandey, Kumar Prabhash, Haladhar Dev Sarma, Ashutosh Dash
Molecular imaging using radiolabeled Tyrosine Kinase Inhibitors (TKI) is a promising strategy for detection and staging of EGFR-positive cancers. A novel analogue of one such TKI, Erlotinib has been developed for PET imaging by derivatizing the parent Erlotinib molecule for conjugation with the bifunctional chelator p-SCN-Bn-NOTA towards radiolabeling with (68)Ga. NOTA-Erlotinib conjugate was synthesized and characterized by NMR and ESI-MS techniques. The conjugate was radiolabeled with (68)Ga in 95±2% yield, as evidenced by HPLC characterization...
September 1, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28892750/neuropathology-and-brain-weight-in-traumatic-crush-asphyxia
#14
Safa Al-Sarraj, Ross Laxton, Ben Swift, Alexander J Kolar, Rob C Chapman, Ashley W Fegan-Earl, Nat R B Cary
Traumatic (crush) asphyxia is a rare condition caused by severe compression of the chest and trunk leading to often extreme so-called asphyxial signs, including cyanosis in head and neck regions, multiple petechiae, and subconjunctival haemorrhage as well as neurological manifestations. AIMS: To investigate the neuropathology and brain weight in traumatic asphyxia caused by different accidents such as industrial accidents and road traffic collision. MATERIAL AND METHODS: Post mortem records of 20 cases of traumatic asphyxia (TA) resulting from different causes of which four brains are available for comprehensive neuropathological examination...
August 25, 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/28891069/use-of-supplemental-anti-hbc-testing-of-donors-showing-non-discriminating-reactive-results-in-multiplex-nucleic-acid-testing
#15
J W Kang, J H Seo, K W Youn, Y I Seo, K Huh, G R Choi, H K Min, D J Oh, H J Jo, J N Kim
BACKGROUND AND OBJECTIVES: The Korean Red Cross began nucleic acid amplification testing (NAT) for HIV and HCV in February 2005, and added HBV NAT beginning in June 2012. The current NAT system utilizes a multiplex assay for simultaneous detection of HBV DNA, HCV RNA and HIV-1 RNA. For samples that are reactive in the multiplex assay, we do specific tests for each virus. However, there have been cases of non-discriminated reactive (NDR) results which appear to be the result of non-specific reactions or cross-contamination, although some cases are considered to arise from the presence of low levels of HBV DNA due to occult hepatitis B infection...
September 10, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28888949/deficiency-of-n-acetyltransferase-increases-the-interactions-of-isoniazid-with-endobiotics-in-mouse-liver
#16
Pengcheng Wang, Amina I Shehu, Jie Lu, Rujuta H Joshi, Raman Venkataramanan, Kim S Sugamori, Denis M Grant, Xiao-Bo Zhong, Xiaochao Ma
Acetylation is the major metabolic pathway of isoniazid (INH) mediated by N-acetyltransferases (NATs). Previous reports suggest that slow acetylators have higher risks of INH hepatotoxicity than rapid acetylators, but the detailed mechanisms remain elusive. The current study used Nat1/2(-/-) mice to mimic NAT slow metabolizers and to investigate INH metabolism in the liver. We found that INH acetylation is abolished in the liver of Nat1/2(-/-) mice, suggesting that INH acetylation is fully dependent on NAT1/2...
September 6, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28885391/abusive-injuries-are-worse-than-vehicular-injuries-should-we-refocus-prevention
#17
Brian D Robertson, Marisa Abbe, Jamie Pelletier, Halim Hennes
OBJECTIVES: The objective of this study was to compare the injury severity and outcome of motor vehicle and nonaccidental traumatic injuries and examine trends in mortality rates over time. METHODS: We reviewed data from 2005 to 2013 from a level 1 pediatric trauma center including demographics, injury severity, and outcomes. Primary outcomes of interest were mortality rates and hospital length of stay. RESULTS: Injury severity scores were significantly worse for nonaccidental traumas (NATs) (P < 0...
September 5, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28883424/efficient-post-acceleration-of-protons-in-helical-coil-targets-driven-by-sub-ps-laser-pulses
#18
H Ahmed, S Kar, G Cantono, P Hadjisolomou, A Poye, D Gwynne, C L S Lewis, A Macchi, K Naughton, G Nersisyan, V Tikhonchuk, O Willi, M Borghesi
The characteristics of laser driven proton beams can be efficiently controlled and optimised by employing a recently developed helical coil technique, which exploits the transient self-charging of solid targets irradiated by intense laser pulses. Here we demonstrate a well collimated (<1° divergence) and narrow bandwidth (~10% energy spread) proton beamlet of ~10(7) particles at 10 ± 0.5 MeV obtained by irradiating helical coil targets with a few joules, sub-ps laser pulses at an intensity of ~2 × 10(19) W cm(-2)...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28878339/pathogen-lineage-based-genome-wide-association-study-identified-cd53-as-susceptible-locus-in-tuberculosis
#19
Yosuke Omae, Licht Toyo-Oka, Hideki Yanai, Supalert Nedsuwan, Sukanya Wattanapokayakit, Nusara Satproedprai, Nat Smittipat, Prasit Palittapongarnpim, Pathom Sawanpanyalert, Wimala Inunchot, Ekawat Pasomsub, Nuanjun Wichukchinda, Taisei Mushiroda, Michiaki Kubo, Katsushi Tokunaga, Surakameth Mahasirimongkol
Tuberculosis (TB) is known to be affected by host genetic factors. We reported a specific genetic risk factor through a genome-wide association study (GWAS) that focused on young age onset TB. In this study, we further focused on the heterogeneity of Mycobacterium tuberculosis (M. tb) lineages and assessed its possible interaction with age at onset on host genetic factors. We identified the pathogen lineage in 686 Thai TB cases and GWAS stratified by both infected pathogen lineage information and age at onset revealed a genome-wide significant association of one single-nucleotide polymorphism (SNP) on chromosome 1p13, which was specifically associated with non-Beijing lineage-infected old age onset cases (P=2...
September 7, 2017: Journal of Human Genetics
https://www.readbyqxmd.com/read/28877955/new-perspectives-in-ocean-acidification-research-editor-s-introduction-to-the-special-feature-on-ocean-acidification
#20
Philip L Munday
Ocean acidification, caused by the uptake of additional carbon dioxide (CO2) from the atmosphere, will have far-reaching impacts on marine ecosystems (Gattuso & Hansson 2011 Ocean acidification Oxford University Press). The predicted changes in ocean chemistry will affect whole biological communities and will occur within the context of global warming and other anthropogenic stressors; yet much of the biological research conducted to date has tested the short-term responses of single species to ocean acidification conditions alone...
September 2017: Biology Letters
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