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fox p2

José Luis Calvo-Guirado, Patricia J López-López, Manuel Fernández Domínguez, Manuel Maiquez Gosálvez, Juan Carlos Prados-Frutos, Sergio Alexandre Gehrke
OBJECTIVE: The aim of this study was to evaluate the effect of topical applications of melatonin and apigenin (4',5,7-trihydroxyflavone) on new bone formation in post-extraction sockets after 30, 60 and 90 days. MATERIALS AND METHODS: Six American fox hounds were used in the study, extracting mandibular premolars (P2, P3 and P4) and first molar (M1). Melatonin or apigenin impregnated in collagen sponges were applied at P3, P4 and M1 sites in both hemimandibles; P2 sites were used as control sites...
May 18, 2016: Clinical Oral Implants Research
Ashleigh Blane, Sylvia Fanucchi
Forkhead box P2 (FOXP2) is a transcription factor expressed in cardiovascular, intestinal, and neural tissues during embryonic development and is implicated in language development. FOXP2 like other FOX proteins contains a DNA binding domain known as the forkhead domain (FHD). The FHD interacts with DNA by inserting helix 3 into the major groove. One of these DNA-protein interactions is a direct hydrogen bond that is formed with His554. FOXP2 is localized in the nuclear compartment that has a pH of 7.5. Histidine contains an imidazole side chain in which the amino group typically has a pKa of ~6...
June 30, 2015: Biochemistry
Jie Kang, Gerald T Mangine, Nicholas A Ratamess, Avery D Faigenbaum, Jay R Hoffman
Exercise routines in which intensity fluctuates, such as Spinning and Treading, are gaining in popularity in fitness industry. However, literature on how this dynamic protocol may affect the exercise metabolism is lacking. The present investigation was undertaken to examine the effect of intensity fluctuation and its magnitude on oxygen uptake and substrate utilization during exercise and recovery. Fifteen men and 15 women were randomly assigned into 1 of the 3 groups consisting of 10 participants of equal gender...
August 2014: Journal of Strength and Conditioning Research
Rafael Arcesio Delgado-Ruiz, Jose Luis Calvo-Guirado, Marcus Abboud, Maria Piedad Ramirez-Fernandez, José Eduardo Maté-Sánchez de Val, Bruno Negri, Gerardo Gomez-Moreno, Aleksa Markovic
PURPOSE: To describe contact, thickness, density, and orientation of connective tissue fibers around healing abutments of different geometries by means of a new method using coordinates. MATERIALS AND METHODS: Following the bilateral extraction of mandibular premolars (P2, P3, and P4) from six fox hound dogs and a 2-month healing period, 36 titanium implants were inserted, onto which two groups of healing abutments of different geometry were screwed: Group A (concave abutments) and Group B (wider healing abutment)...
August 2015: Clinical Implant Dentistry and related Research
Tania A Seabrook, Rana N El-Danaf, Thomas E Krahe, Michael A Fox, William Guido
Neurons in layer VI of visual cortex represent one of the largest sources of nonretinal input to the dorsal lateral geniculate nucleus (dLGN) and play a major role in modulating the gain of thalamic signal transmission. However, little is known about how and when these descending projections arrive and make functional connections with dLGN cells. Here we used a transgenic mouse to visualize corticogeniculate projections to examine the timing of cortical innervation in dLGN. Corticogeniculate innervation occurred at postnatal ages and was delayed compared with the arrival of retinal afferents...
June 12, 2013: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
J G Suway, L K White, R E Vanderwert, Y Bar-Haim, D S Pine, N A Fox
BACKGROUND AND OBJECTIVES: Previous research suggests that attention bias toward threat contributes to the development and maintenance of anxiety. The current study extends this work by mapping the neural correlates of experimentally-induced changes in attention bias. The study examines both behavioral and psychophysiological changes associated with experimentally-induced changes in threat bias. METHODS: Thirty-four non-anxious female adults were randomly assigned to one of two conditions: training attention toward threat or placebo control...
September 2013: Journal of Behavior Therapy and Experimental Psychiatry
Matthew T Roe, Paul W Armstrong, Keith A A Fox, Harvey D White, Dorairaj Prabhakaran, Shaun G Goodman, Jan H Cornel, Deepak L Bhatt, Peter Clemmensen, Felipe Martinez, Diego Ardissino, Jose C Nicolau, William E Boden, Paul A Gurbel, Witold Ruzyllo, Anthony J Dalby, Darren K McGuire, Jose L Leiva-Pons, Alexander Parkhomenko, Shmuel Gottlieb, Gracita O Topacio, Christian Hamm, Gregory Pavlides, Assen R Goudev, Ali Oto, Chuen-Den Tseng, Bela Merkely, Vladimir Gasparovic, Ramon Corbalan, Mircea Cinteză, R Craig McLendon, Kenneth J Winters, Eileen B Brown, Yuliya Lokhnygina, Philip E Aylward, Kurt Huber, Judith S Hochman, E Magnus Ohman
BACKGROUND: The effect of intensified platelet inhibition for patients with unstable angina or myocardial infarction without ST-segment elevation who do not undergo revascularization has not been delineated. METHODS: In this double-blind, randomized trial, in a primary analysis involving 7243 patients under the age of 75 years receiving aspirin, we evaluated up to 30 months of treatment with prasugrel (10 mg daily) versus clopidogrel (75 mg daily). In a secondary analysis involving 2083 patients 75 years of age or older, we evaluated 5 mg of prasugrel versus 75 mg of clopidogrel...
October 4, 2012: New England Journal of Medicine
Pavle Mocilac, Katie Donnelly, John F Gallagher
An isomer grid of nine fluoro-N-(pyridyl)benzamides (Fxx) (x = para-/meta-/ortho-) has been examined to correlate structural relationships between the experimental crystal structure and ab initio calculations, based on the effect of fluorine (Fx) and pyridine N-atom (x) substitution patterns on molecular conformation. Eight isomers form N-H⋅⋅⋅N hydrogen bonds, and only one (Fom) aggregates via intermolecular N-H⋅⋅⋅O=C interactions exclusively. The Fpm and Fom isomers both crystallize as two polymorphs with Fpm_O (N-H⋅⋅⋅O=C chains, P-syn) and Fpm_N (N-H⋅⋅⋅N chains, P-anti) both in P2(1)/n (Z' = 1) differing by their meta-N atom locations (P-syn, P-anti; N(pyridine) referenced to N-H), whereas the disordered Fom_O is mostly P-syn (Z' = 6) compared with Fom_F (P-anti) (Z' = 1)...
April 2012: Acta Crystallographica. Section B, Structural Science
Yamei Liu, Victor G Stepanov, Ulrich Strych, Richard C Willson, George W Jackson, George E Fox
BACKGROUND: Manufacturing large quantities of recombinant RNAs by overexpression in a bacterial host is hampered by their instability in intracellular environment. To overcome this problem, an RNA of interest can be fused into a stable bacterial RNA for the resulting chimeric construct to accumulate in the cytoplasm to a sufficiently high level. Being supplemented with cost-effective procedures for isolation of the chimera from cells and recovery of the recombinant RNA from stabilizing scaffold, this strategy might become a viable alternative to the existing methods of chemical or enzymatic RNA synthesis...
2010: BMC Biotechnology
Chee Tang Chin, Matthew T Roe, Keith A A Fox, Dorairaj Prabhakaran, Debra A Marshall, Helene Petitjean, Yuliya Lokhnygina, Eileen Brown, Paul W Armstrong, Harvey D White, E Magnus Ohman
Practice guidelines recommend dual antiplatelet therapy with aspirin and clopidogrel for patients with non-ST-segment elevation acute coronary syndromes (NSTE ACS) regardless of in-hospital management strategy. Prasugrel-a thienopyridine adenosine diphosphate receptor antagonist that provides higher and less variable levels of platelet inhibition than clopidogrel-has demonstrated benefit when used to treat ACS patients undergoing percutaneous coronary intervention. However, the optimal approach to antiplatelet therapy for high-risk, medically managed NSTE ACS patients remains uncertain, as these patients have not been the focus of previous clinical trials of these therapies...
July 2010: American Heart Journal
Helen Keyes, Nuala Brady, Richard B Reilly, John J Foxe
The neural basis of self-recognition is mainly studied using brain-imaging techniques which reveal much about the localization of self-processing in the brain. There are comparatively few studies using EEG which allow us to study the time course of self-recognition. In this study, participants monitored a sequence of images, including 20 distinct images of their own face, a friend's face and a stranger's face articulating different speech sounds, while EEG was recorded from 64 scalp electrodes. Differences in the ERP waveforms were observed very early on, with increased N170 and VPP amplitude to self relative to both friend and stranger measured over posterior and fronto-central sites, respectively...
March 2010: Brain and Cognition
Stan Heptinstall, David Iyu Espinosa, Panagiotis Manolopoulos, Jackie R Glenn, Ann E White, Andrew Johnson, Natalia Dovlatova, Sue C Fox, Jane A May, David Hermann, Olafur Magnusson, Kari Stefansson, Dan Hartman, Mark Gurney
Receptors for prostanoids on platelets include the EP3 receptor for which the natural agonist is the inflammatory mediator prostaglandin E(2) (PGE(2)) produced in atherosclerotic plaques. EP3 is implicated in atherothrombosis and an EP3 antagonist might provide atherosclerotic lesion-specific antithrombotic therapy. DG-041 (2,3-dichlorothiophene-5-sulfonic acid, 3-[1-(2,4-dichlorobenzyl)-5-fluoro-3-methyl-1H-indol-7-yl]acryloylamide) is a direct-acting EP3 antagonist currently being evaluated in Phase 2 clinical trials...
December 2008: Platelets
Natalia Dovlatova, Yanushi D Wijeyeratne, Susan C Fox, Panagiotis Manolopoulos, Andrew J Johnson, Ann E White, M Liaque Latif, Vera Ralevic, Stanley Heptinstall
mRNA encoding the recently discovered P2Y(14) receptor has been reported in platelets, but the presence of P2Y(14) receptor protein and its functionality have not been studied. If P2Y(14) is expressed along with P2Y(1) and P2Y(12) receptors it may have a role in haemostasis. It was the objective of this study to investigate the presence of the P2Y(14) receptor in platelets and its role in platelet function. The effects of the agonist UDP-glucose were compared with those of sulprostone, a selective EP(3) receptor agonist...
August 2008: Thrombosis and Haemostasis
P Manolopoulos, J R Glenn, S C Fox, J A May, N L Dovlatova, S-W Tang, N R Thomas, V Ralevic, S Heptinstall
We have performed a detailed investigation of the effects on platelet function of coenzyme A (CoA) and several acyl-CoAs. Platelet aggregation was measured by turbidimetry and by platelet counting; platelet shape change was measured using light scattering; P-selectin, Ca2+ mobilization and vasodilator-stimulated phosphoprotein (VASP) phosphorylation were measured by flow cytometry. The compounds investigated inhibited ADP-induced platelet aggregation; those with saturated acyl groups containing 16-18 carbons were most effective...
March 2008: Platelets
Kathryne S Auernik, Yukari Maezato, Paul H Blum, Robert M Kelly
Despite their taxonomic description, not all members of the order Sulfolobales are capable of oxidizing reduced sulfur species, which, in addition to iron oxidation, is a desirable trait of biomining microorganisms. However, the complete genome sequence of the extremely thermoacidophilic archaeon Metallosphaera sedula DSM 5348 (2.2 Mb, approximately 2,300 open reading frames [ORFs]) provides insights into biologically catalyzed metal sulfide oxidation. Comparative genomics was used to identify pathways and proteins involved (directly or indirectly) with bioleaching...
February 2008: Applied and Environmental Microbiology
Ruben G Xavier, Ann E White, Susan C Fox, Robert G Wilcox, Stan Heptinstall
The effects on platelet function of temperatures attained during hypothermia used in cardiac surgery are controversial. Here we have performed studies on platelet aggregation in whole blood and platelet-rich plasma after stimulation with a range of concentrations of ADP, TRAP, U46619 and PAF at both 28 degrees C and 37 degrees C. Spontaneous aggregation was also measured after addition of saline alone. In citrated blood, spontaneous aggregation was markedly enhanced at 28 degrees C compared with 37 degrees C...
December 2007: Thrombosis and Haemostasis
A L Frelinger, J A Jakubowski, Y Li, M R Barnard, M D Linden, I Tarnow, M L Fox, A Sugidachi, K J Winters, M I Furman, A D Michelson
BACKGROUND: Prasugrel is a novel antiplatelet prodrug of the same thienopyridine class as clopidogrel and ticlopidine. Metabolism of prasugrel generates the active metabolite R-138727, an antagonist of the platelet P2Y(12) adenosine diphosphate (ADP) receptor, leading to inhibition of ADP-mediated platelet activation and aggregation. ADP also enhances the platelet response to collagen, and these two agonists contribute to the generation of platelet procoagulant activity. We therefore examined whether R-138727 inhibits ADP- and collagen-triggered platelet procoagulant activities...
February 2008: Journal of Thrombosis and Haemostasis: JTH
Fred L Johnson, José L Boyer, Philip T Leese, Christopher Crean, Ramesh Krishnamoorthy, Todd Durham, Anthony W Fox, Donald J Kellerman
P2Y(12) receptors participate in ADP-induced activation and aggregation of human platelets. INS50589, a selective P2Y(12) receptor antagonist, is being developed for use where controlled, reversible modulation of the platelet hemostatic function is needed. The tolerability, pharmacokinetics, and pharmacodynamics of INS50589 were tested in healthy human volunteers. Thirty-six subjects received intravenous infusions of placebo or INS50589 at 0.1-3 mg/kg/h for four hours. Platelet function, clotting parameters, bleeding time, safety assessments, and plasma concentrations of INS50589 and its major metabolite were monitored for 24 hours...
August 2007: Platelets
Andrew L Frelinger, Joseph A Jakubowski, Youfu Li, Marc R Barnard, Marsha L Fox, Matthew D Linden, Atsuhiro Sugidachi, Kenneth J Winters, Mark I Furman, Alan D Michelson
The novel thienopyridine prodrug prasugrel, a platelet P2Y(12) ADP receptor antagonist, requires in vivo metabolism for activity. Although pharmacological data have been collected on the effects of prasugrel on platelet aggregation, there are few data on the direct effects of the prasugrel's active metabolite, R-138727, on other aspects of platelet function. Here we examined the effects of R-138727 on thrombo-inflammatory markers of platelet activation, and the possible modulatory effects of other blood cells, calcium, and aspirin...
July 2007: Thrombosis and Haemostasis
Akifumi Mizutani, Ayumi Matsuzaki, Mariko Y Momoi, Eriko Fujita, Yuko Tanabe, Takashi Momoi
Although a mutation (R553H) in the forkhead box (FOX)P2 gene is associated with speech/language disorder, little is known about the function of FOXP2 or its relevance to this disorder. In the present study, we identify the forkhead nuclear localization domains that contribute to the cellular distribution of FOXP2. Nuclear localization of FOXP2 depended on two distally separated nuclear localization signals in the forkhead domain. A truncated version of FOXP2 lacking the leu-zip, Zn2+ finger, and forkhead domains that was observed in another patient with speech abnormalities demonstrated an aggregated cytoplasmic localization...
February 23, 2007: Biochemical and Biophysical Research Communications
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