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Cardiac regeneration

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https://www.readbyqxmd.com/read/29244726/potential-of-bioactive-glasses-for-cardiac-and-pulmonary-tissue-engineering
#1
REVIEW
Saeid Kargozar, Sepideh Hamzehlou, Francesco Baino
Repair and regeneration of disorders affecting cardiac and pulmonary tissues through tissue-engineering-based approaches is currently of particular interest. On this matter, different families of bioactive glasses (BGs) have recently been given much consideration with respect to treating refractory diseases of these tissues, such as myocardial infarction. The inherent properties of BGs, including their ability to bond to hard and soft tissues, to stimulate angiogenesis, and to elicit antimicrobial effects, along with their excellent biocompatibility, support these newly proposed strategies...
December 15, 2017: Materials
https://www.readbyqxmd.com/read/29243046/-stem-cell-based-cardiac-regeneration-after-myocardial-infarction
#2
REVIEW
M Reinsch, F Weinberger
Myocardial infarction leads to an irreversible loss of vital myocardial cells. The transplantation of new cardiomyocytes into the heart was first described over 20 years ago and represents a straightforward approach to remuscularize a damaged heart. Due to the lack of human cells a clinical application seemed ambitious; however, dramatic progress in stem cell biology over the last two decades has paved the way towards a clinical application. This is especially important as the prognosis for patients with terminal heart failure is still poor...
December 14, 2017: Herz
https://www.readbyqxmd.com/read/29238048/cardiac-regeneration-a-hydrogel-mirna-complex-stimulates-heart-recovery
#3
Irene Fernández-Ruiz
No abstract text is available yet for this article.
December 14, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/29232369/accelerated-decline-in-cardiac-stem-cell-efficiency-in-spontaneously-hypertensive-rat-compared-to-normotensive-wistar-rat
#4
Sherin Saheera, Renuka R Nair
Cardiac hypertrophy is recognized as an independent risk factor for cardiac failure. Efficient management of hypertensive heart disease requires identification of factors that can possibly mediate the transition from hypertrophy to failure. Resident cardiac stem cells have a prominent role in the maintenance of cardiac tissue homeostasis. Decline in the proportion of healthy cardiac stem cells (CSCs) can affect tissue regeneration. In pathological conditions, apart from natural aging, an adverse microenvironment can lead to decrease in efficiency of CSCs...
2017: PloS One
https://www.readbyqxmd.com/read/29225628/noncoding-rna-and-cardiomyocyte-proliferation
#5
REVIEW
Shuang Qu, Chunyu Zeng, Wei Eric Wang
It is acknowledged that postnatal mammalian cardiomyocytes (CMs) turn over with a very limited efficacy in both physiological and pathological conditions. Recent studies showed that those newly formed CMs are derived from preexisting CMs. Thus, stimulating CM proliferation becomes a promising strategy for inducing cardiac regeneration. Noncoding RNAs were found differently expressed in CMs with different proliferation potential. Moreover, manipulation of noncoding RNAs, in particular microRNAs, was proved to promote or suppress CM proliferation, indicating that noncoding RNAs are involved in the underlying mechanism of CM proliferation...
2017: Stem Cells International
https://www.readbyqxmd.com/read/29225198/perspective-in-optimization-of-stem-cell-therapies-for-heart-regeneration
#6
Paulina Gapska, Maciej Kurpisz
There is a variety of mechanisms(s) factor(s) that may influence stem cell therapies for heart regeneration. Among the best candidates for stem cell source are: mesenchymal stem cells (also those isolated from adipose tissue), cardiac cell progenitors (CPC) and descendants of iPSC cells. iPSC/s can be potentially beneficial although their pluripotent induction has been still in question due to: low propagation efficacy, danger of genomic integration/instability, biological risk of current vector system teratoma formation etc...
December 7, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/29223542/interval-exercise-training-increases-lif-expression-and-prevents-myocardial-infarction-induced-skeletal-muscle-atrophy-in-rats
#7
Dandan Jia, Mengxin Cai, Yue Xi, Shaojun Du, ZhenjunTian
AIMS: Myocardial infarction (MI) is commonly associated with body weight loss and skeletal muscle atrophy. Studies have shown that exercise training could give beneficial effects on skeletal muscle growth. Leukemia inhibitory factor (LIF) is a key regulator of muscle growth and regeneration. The aim of this study was to investigate the effects of interval exercise training (IET) on the expression of LIF and the MI-induced skeletal muscle atrophy. MAIN METHODS: Male Sprague-Dawley rats were used to establish the MI model by ligation of the left anterior descending coronary artery...
December 6, 2017: Life Sciences
https://www.readbyqxmd.com/read/29216265/oct4-expression-mediates-partial-cardiomyocyte-reprogramming-of-mesenchymal-stromal-cells
#8
Gustavo Yannarelli, Natalia Pacienza, Sonia Montanari, Diego Santa-Cruz, Sowmya Viswanathan, Armand Keating
Mesenchymal stem/stromal cells (MSCs) are in numerous cell therapy clinical trials, including for injured myocardium. Acquisition of cardiomyocyte characteristics by MSCs may improve cardiac regeneration but the mechanisms regulating this process are unclear. Here, we investigated whether the pluripotency transcription factor OCT4 is involved in the activation of cardiac lineage genetic programs in MSCs. We employed our established co-culture model of MSCs with rat embryonic cardiomyocytes showing co-expression of cardiac markers on MSCs independent of cell fusion...
2017: PloS One
https://www.readbyqxmd.com/read/29215066/pharmacological-inhibition-of-rev-erb-stimulates-differentiation-inhibits-turnover-and-reduces-fibrosis-in-dystrophic-muscle
#9
Ryan D Welch, Cyrielle Billon, Aurore-Cecile Valfort, Thomas P Burris, Colin A Flaveny
Duchenne muscular dystrophy (DMD) is a debilitating X-linked disorder that is fatal. DMD patients lack the expression of the structural protein dystrophin caused by mutations within the DMD gene. The absence of functional dystrophin protein results in excessive damage from normal muscle use due to the compromised structural integrity of the dystrophin associated glycoprotein complex. As a result, DMD patients exhibit ongoing cycles of muscle destruction and regeneration that promote inflammation, fibrosis, mitochondrial dysfunction, satellite cell (SC) exhaustion and loss of skeletal and cardiac muscle function...
December 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29215012/rest-regulates-the-cell-cycle-for-cardiac-development-and-regeneration
#10
Donghong Zhang, Yidong Wang, Pengfei Lu, Ping Wang, Xinchun Yuan, Jiangyun Yan, Chenleng Cai, Ching-Pin Chang, Deyou Zheng, Bingruo Wu, Bin Zhou
Despite the importance of cardiomyocyte proliferation in cardiac development and regeneration, the mechanisms that promote cardiomyocyte cell cycle remain incompletely understood. RE1 silencing transcription factor (REST) is a transcriptional repressor of neuronal genes. Here we show that REST also regulates the cardiomyocyte cell cycle. REST binds and represses the cell cycle inhibitor gene p21 and is required for mouse cardiac development and regeneration. Rest deletion de-represses p21 and inhibits the cardiomyocyte cell cycle and proliferation in embryonic or regenerating hearts...
December 7, 2017: Nature Communications
https://www.readbyqxmd.com/read/29207135/bfgf-promotes-sca%C3%A2-1-cardiac-stem-cell-migration-through-activation-of-the-pi3k-akt-pathway
#11
Lin Ling, Shaohua Gu, Yan Cheng, Liucheng Ding
Cardiac stem cells (CSCs) are important for improving cardiac function following myocardial infarction, with CSC migration to infarcted or ischemic myocardium important for cardiac regeneration. Strategies to improve cell migration may improve the efficiency of myocardial regeneration. Basic fibroblast growth factor (bFGF) is an essential molecule in cell migration, but the endogenous bFGF level is too low to be effective. The effect of exogenously delivered bFGF on CSC migration was observed in vitro and in vivo in the present study...
November 28, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29206745/cardiosphere-derived-cells-and-ischemic-heart-failure
#12
Carmel Ashur, William H Frishman
After a myocardial infarction, heart tissue becomes irreversibly damaged, leading to scar formation and inevitably ischemic heart failure. Of the many available interventions after a myocardial infarction, such as percutaneous intervention or pharmacological optimization, none can reverse the ischemic insult on the heart and restore cardiac function. Thus, the only available cure for patients with scarred myocardium is allogeneic heart transplantation, which comes with extensive costs, risks, and complications...
January 2018: Cardiology in Review
https://www.readbyqxmd.com/read/29206329/cardiac-tissue-regeneration-a-preliminary-study-on-carbon-based-nanotubes-gelatin-scaffold
#13
Manuela Cabiati, Federico Vozzi, Federica Gemma, Francesca Montemurro, Carmelo De Maria, Giovanni Vozzi, Claudio Domenici, Silvia Del Ry
The aim of this study was set-up and test of gelatin and carbon nanotubes scaffolds. Gelatin-based (5%) genipin cross-linked (0.2%) scaffolds embedding single-walled carbon nanotubes (SWCNTs, 0.3, 0.5, 0.7, 0.9, and 1.3% w/w) were prepared and mechanically/electrically characterized. For biological evaluation, H9c2 cell line was cultured for 10 days. Cytotoxicity, cell growth and differentiation, immunohistochemistry, and real-time PCR analysis were performed. Myoblast and cardiac differentiation were obtained by serum reduction to 1% (C1% ) and stimulation with 50 nM all trans-retinoic acid (CRA ), respectively...
December 5, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29201433/heart-regeneration-in-the-salamander-relies-on-macrophage-mediated-control-of-fibroblast-activation-and-the-extracellular-landscape
#14
J W Godwin, R Debuque, E Salimova, N A Rosenthal
In dramatic contrast to the poor repair outcomes for humans and rodent models such as mice, salamanders and some fish species are able to completely regenerate heart tissue following tissue injury, at any life stage. This capacity for complete cardiac repair provides a template for understanding the process of regeneration and for developing strategies to improve human cardiac repair outcomes. Using a cardiac cryo-injury model we show that heart regeneration is dependent on the innate immune system, as macrophage depletion during early time points post-injury results in regeneration failure...
2017: NPJ Regenerative Medicine
https://www.readbyqxmd.com/read/29199067/pressure-induced-microstructural-changes-in-porcine-tricuspid-valve-leaflets
#15
Anup D Pant, Vineet S Thomas, Anthony L Black, Taylor Verba, John G Lesicko, Rouzbeh Amini
Quantifying mechanically-induced changes in the tricus anisotropy index, a measure ofpid valve extracellular matrix (ECM) structural components, e.g. collagen fiber spread and distribution, is important as it determines the overall macro-scale tissue responses and subsequently its function/malfunction in physiological/pathophysiological states. For example, functional tricuspid regurgitation, a common tricuspid valve disorder, could be caused by elevated right ventricular pressure due to pulmonary hypertension...
November 30, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29198068/fibroblast-growth-factor-9-subfamily-and-the-heart
#16
REVIEW
Shen Wang, Yong Li, Chao Jiang, Haishan Tian
The fibroblast growth factor (FGF) 9 subfamily is a member of the FGF family, including FGF9, 16, and 20, potentially sharing similar biochemical functions due to their high degree of sequence homology. Unlike other secreted proteins which have a cleavable N-terminal secreted signal peptide, FGF9/16/20 have non-cleaved N-terminal signal peptides. As an intercellular signaling molecule, they are involved in a variety of complex responses in animal development. Cardiogenesis is controlled by many members of the transcription factor family...
December 2, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29196619/opposite-effects-of-activin-type-2-receptor-ligands-on-cardiomyocyte-proliferation-during-development-and-repair
#17
Deepika Dogra, Suchit Ahuja, Hyun-Taek Kim, S Javad Rasouli, Didier Y R Stainier, Sven Reischauer
Zebrafish regenerate damaged myocardial tissue very effectively. Hence, insights into the molecular networks underlying zebrafish heart regeneration might help develop alternative strategies to restore human cardiac performance. While TGF-β signaling has been implicated in zebrafish cardiac regeneration, the role of its individual ligands remains unclear. Here, we report the opposing expression response during zebrafish heart regeneration of two genes, mstnb and inhbaa, which encode TGF-β family ligands...
December 1, 2017: Nature Communications
https://www.readbyqxmd.com/read/29187216/use-of-a-flowable-haemostat-versus-an-oxidised-regenerated-cellulose-agent-in-primary-elective-cardiac-surgery-economic-impact-from-a-uk-healthcare-perspective
#18
Mayur R Joshi, Jacqueline Latham, Gabriel Okorogheye
BACKGROUND: Flowable haemostatic agents have been shown to be superior to non-flowable agents in terms of haemostatic control and need for transfusion products in patients undergoing cardiac surgery. We investigated the economic impact of the use of a flowable haemostatic agent (Floseal) compared with non-flowable oxidised regenerated cellulose (ORC) agent in primary elective cardiac surgery from the perspective of the UK National Health Service (NHS). METHODS: A cost-consequence framework based upon clinical data from a prospective trial and an observational trial and NHS-specific actual reference costs (2016) was developed to compare the economic impact of Floseal with that of ORC...
November 29, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29179985/cardiac-cd68-and-stabilin-1-macrophages-in-wound-healing-following-myocardial-infarction-from-experiment-to-clinic
#19
Vyacheslav Ryabov, Aleksandra Gombozhapova, Yuliya Rogovskaya, Julia Kzhyshkowska, Mariya Rebenkova, Rostislav Karpov
Myocardial infarction (MI) remains the leading cause of mortality and morbidity throughout the world. Macrophages are key innate immune cells that play a significant role in transition from the inflammatory to the regenerative phase during wound healing following MI. The scavenger receptor stabilin-1 is one of the most interesting macrophage biomarkers. This receptor contributes to wound healing, angiogenesis, and tissue remodeling. We suggested a research protocol using macrophage biomarkers to study the cellular basis of cardiac remodeling and healing in patients with acute MI...
November 22, 2017: Immunobiology
https://www.readbyqxmd.com/read/29173898/human-pluripotent-stem-cell-differentiation-into-functional-epicardial-progenitor-cells
#20
Juan Antonio Guadix, Valeria V Orlova, Elisa Giacomelli, Milena Bellin, Marcelo C Ribeiro, Christine L Mummery, José M Pérez-Pomares, Robert Passier
Human pluripotent stem cells (hPSCs) are widely used to study cardiovascular cell differentiation and function. Here, we induced differentiation of hPSCs (both embryonic and induced) to proepicardial/epicardial progenitor cells that cover the heart during development. Addition of retinoic acid (RA) and bone morphogenetic protein 4 (BMP4) promoted expression of the mesodermal marker PDGFRα, upregulated characteristic (pro)epicardial progenitor cell genes, and downregulated transcription of myocardial genes...
November 17, 2017: Stem Cell Reports
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