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https://www.readbyqxmd.com/read/28738637/sensitive-detection-of-estriol-hormone-in-creek-water-using-a-sensor-platform-based-on-carbon-black-and-silver-nanoparticles
#1
Paulo A Raymundo-Pereira, Anderson M Campos, Fernando C Vicentini, Bruno C Janegitz, Camila D Mendonça, Leonardo N Furini, Naiza V Boas, Marcelo L Calegaro, Carlos J L Constantino, Sergio A S Machado, Osvaldo N Oliveira
We report the electrochemical detection of estriol using carbon black nanoballs (CNB) decorated with silver nanoparticles (AgNP) as electrode material. Homogeneous, porous films on glassy carbon electrodes (GCE) were obtained, with diameters of 20 - 25nm for CNB and 5 - 6nm for AgNP. CNB/AgNP electrodes had increased conductivity and electroactive area in comparison with bare GCE and GCE/CNB, according to cyclic voltammetry and electrochemical impedance spectroscopy. The oxidation potential peak was also down shifted by 93mV, compared to the bare GC electrode...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738629/innovative-simple-and-green-ultrasound-assisted-enzyme-based-hydrolytic-microextraction-method-for-manganese-at-trace-levels-in-food-samples
#2
Erkan Yilmaz, Mustafa Soylak
We describe the usage of hydrolytic enzymes for the innovative, green and simple microextraction of manganese in food samples. The ultrasound assisted-enzyme based hydrolytic microextraction method (UA-EH-ME) was applied for the separation and determination of manganese in food samples prior to its micro-sampling flame atomic absorption spectrometric determination (MS-FAAS). Analytical parameters influenced on the enzyme based hydrolytic microextraction method such as pH, type of enzyme, amount of enzyme, temperature and time of ultrasonic waves were fully evaluated and optimized by using mg level of NCS ZC73033 scallion certified reference material...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738574/a-highly-selective-and-sensitive-fluorescent-probe-for-hypochlorous-acid-and-its-lysosome-targetable-biological-applications
#3
Chang Liu, Xiaojie Jiao, Song He, Liancheng Zhao, Xianshun Zeng
A novel lysosome-targetable fluorescence probe PT-1 based on a photoinduced electron transfer (PET) mechanism has been designed and synthesized. For comparison, the probe PT-2 without morpholine moiety as a lysosome-directing group was also synthesized and investigated. Probes PT-1 and PT-2 exhibited high selectivity, high sensitivity (with the detection limits down to the 10(-10)M range) and response in real time (within 10s) toward HOCl over other reactive oxygen species (ROS). Both PT-1 and PT-2 were cell permeable and enabled them to be used for monitoring of HOCl in living cells...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738535/role-of-gab1-pi3k-akt-signaling-high-glucose-induced-cardiomyocyte-apoptosis
#4
Dongmei Su, Yunjun Zhou, Shanshan Hu, Lina Guan, Cuige Shi, Qi Wang, Yingyu Chen, Cailing Lu, Qian Li, Xu Ma
Gestational diabetes mellitus (GDM) is a risk factor for abnormal heart development. Previous work showed that a decrease of myocardial cells and an increase of apoptotic cells leading to heart defects under hyperglycemia, and many genes and protein have been found to play important roles in cardiomyocyte apoptosis. However, there are still many blind nodes in HG-induced cardiac apoptosis. Our study showed that down-regulation of GAB1 occurred concurrently with HG-induced cardiomyocytes apoptosis and in the heart tissues of offspring of diabetic rats in vitro and in vivo...
July 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28738526/the-potential-of-chrysophanol-in-protecting-against-high-fat-induced-cardiac-injury-through-nrf2-regulated-anti-inflammation-anti-oxidant-and-anti-fibrosis-in-nrf2-knockout-mice
#5
Yonggang Lian, Xiangjun Xia, Haiying Zhao, Yunfeng Zhu
Cardiovascular complications induced by high fat are one of the most challenging health problems presently. Oxidative stress, inflammation and fibrosis are major components included in the pathology of diabetic cardiomyopathy. Nuclear factor erythroid 2-related factor 2 (Nrf2) has been reported as an essential therapeutic target in various diseases for its induction of anti-oxidant enzymes, and other protective enzymes. Additionally, a number of Nrf2 activators showed strong anti-inflammatory properties. In the study, we calculated the Nrf2-dependent anti-oxidant, anti-inflammatory and anti-fibrosis effects of chrysophanol in high fat diet-induced diabetic heart injury...
July 19, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28738521/ginkgo-biloba-exocarp-extracts-induces-autophagy-in-lewis-lung-cancer-cells-involving-ampk-mtor-p70s6k-signaling-pathway
#6
Chenjie Cao, Dongdong Han, Ya Su, Yu Ge, Huasheng Chen, Aihua Xu
OBJECTIVES: Ginkgo biloba L. is called a living fossil plant, and could be used for the treatment of cancer thousands of years ago in China. The extracts prepared from the Ginkgo biloba exocarp (Ginkgo biloba exocarp extracts, GBEE) has a significant anti-cancer effect. Autophagy plays an important role in the occurrence and development of cancer as programmed cell death (PCD) type II. Thus it would be interesting to study the effects and mechanisms of GBEE inducing autophagy in Lewis lung cancer (LLC) cells...
July 19, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28738514/unraveling-the-impact-of-nanoscale-zero-valent-iron-on-the-nitrogen-removal-performance-and-microbial-community-of-anammox-sludge
#7
Zheng-Zhe Zhang, Jia-Jia Xu, Zhi-Jian Shi, Yu-Hui Bai, Ya-Fei Cheng, Hai-Yan Hu, Ren-Cun Jin
Given the increasing use of nanoscale zero-valent iron (NZVI) particles for environmental remediation and wastewater treatment, their potential impact on anaerobic ammonium oxidation (anammox) bacteria was investigated in this study using anammox sludge. Batch assays showed that NZVI concentrations up to 200mgL(-1) did not affect anammox activity, reactive oxygen species production, and cell membrane integrity. The nitrogen removal efficiency of the continuous-flow reactor fluctuated in the presence of 20 or 50mgL(-1) NZVI, but it could return to normal over time, even at 200mgL(-1) NZVI...
July 11, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28738500/mir-101-3p-inhibits-the-growth-and-metastasis-of-non-small-cell-lung-cancer-through-blocking-pi3k-akt-signal-pathway-by-targeting-malat-1
#8
Xiaoqiang Zhang, Xianju He, Yunbing Liu, Huiqing Zhang, He Chen, Shanxian Guo, Yonggang Liang
BACKGROUND: MiR-101-3p is an important tumor suppressor miRNA in many human cancers. This study was to investigate the role of miR-101-3p in the progression of non-small cell lung cancer (NSCLC) and its potential underlying mechanism. METHODS: In this study, the endogenous expression of miR-101-3p or MALAT-1 in cells was modulated by cell transfection assays. The regulatory interaction of miR-101-3p and MALAT-1 was examined by Luciferase reporter gene and RNA pull-down assays...
July 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28738498/microrna-299-3p-suppresses-proliferation-and-invasion-by-targeting-vegfa-in-human-colon-carcinoma
#9
Jia-Yong Wang, Jin-Bo Jiang, Yuan Li, Yan-Lei Wang, Yong Dai
Accumulating evidences have shown that microRNAs (miRNAs) are vital regulators and possess huge capabilities in post-transcriptional control. Although a large number of miRNAs have been identified to be dysregulated in human cancers especially in colon cancer, our understandings of the function of most miRNAs are still largely limited. In this study, we have demonstrated that miR-299-3p plays a critical role in suppressing colon carcinoma progression by targeting Vascular Endothelial Growth Factor A (VEGFA)...
July 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28738420/variation-in-the-three-dimensional-histomorphometry-of-the-normal-human-optic-nerve-head-with-age-and-race-lamina-cribrosa-and-peripapillary-scleral-thickness-and-position
#10
Christopher A Girkin, Massimo A Fazio, Hongli Yang, Juan Reynaud, Claude F Burgoyne, Brandon Smith, Lan Wang, J Crawford Downs
Purpose: This study quantified the thickness and depth of the lamina cribrosa (LC) and peripapillary scleral thickness in high-resolution three-dimensional (3D) fluorescent reconstructions of the optic nerve head (ONH) in eyes from donors of African (AD) and European descent (ED). Methods: A total of 64 eyes (45 ED, 19 AD) from 51 normal donors were obtained within 6 hours of death and fixed at 10 mm Hg of pressure. The optic nerve head was trephined from the globe and digitally reconstructed at 1...
July 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28738410/no-large-population-of-unbound-or-wide-orbit-jupiter-mass-planets
#11
Przemek Mróz, Andrzej Udalski, Jan Skowron, Radosław Poleski, Szymon Kozłowski, Michał K Szymański, Igor Soszyński, Łukasz Wyrzykowski, Paweł Pietrukowicz, Krzysztof Ulaczyk, Dorota Skowron, Michał Pawlak
Planet formation theories predict that some planets may be ejected from their parent systems as result of dynamical interactions and other processes. Unbound planets can also be formed through gravitational collapse, in a way similar to that in which stars form. A handful of free-floating planetary-mass objects have been discovered by infrared surveys of young stellar clusters and star-forming regions as well as wide-field surveys, but these studies are incomplete for objects below five Jupiter masses. Gravitational microlensing is the only method capable of exploring the entire population of free-floating planets down to Mars-mass objects, because the microlensing signal does not depend on the brightness of the lensing object...
July 24, 2017: Nature
https://www.readbyqxmd.com/read/28738343/mir-26a-b-inhibit-tumor-growth-and-angiogenesis-by-targeting-the-hgf-vegf-axis-in-gastric-carcinoma
#12
Yiran Si, Haiyang Zhang, Tao Ning, Ming Bai, Yi Wang, Haiou Yang, Xinyi Wang, Jialu Li, Guoguang Ying, Yi Ba
BACKGROUND/AIMS: Abnormal expression of HGF is found in various cancers and correlates with tumor proliferation, metastasis and angiogenesis. However, the regulatory mechanism of the HGF-VEGF axis remains unclear. METHODS: The expression characteristic of HGF in human gastric cancer tissues was shown by an immunohistochemistry assay, and the expression levels of target protein were detected by Western blot. The relative levels of miR-26a/b and target mRNA were examined by qRT-PCR...
July 24, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28738331/future-perspectives-in-sleep-medicine
#13
Leh-Kiong Anne Huon, Christian Guilleminault
"Sleep Medicine" is now a specialty in its own right. Currently, there is increasing recognition of the very negative impact sleep disorders have on learning, education, safety, and quality of life. Technological advances will help us to break down diagnoses (e.g., narcolepsy has now been subdivided into types 1 and 2, depending upon the hypocretin levels in the spinal fluid) and to discover relationships to other bodily systems (e.g., type 1 narcolepsy potentially being an autoimmune disorder). The modern lifestyle of many, as characterized by a shortening of sleep periods, shift work, jet lag, and the need to be constantly available, means that advances in sleep medicine may result in a major understanding of more balanced "work-rest lifestyle" modifications...
2017: Advances in Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28738308/antiproliferative-and-pro-apoptotic-activities-of-2-and-4-aminochalcones-against-tumor-canine-cells
#14
Mariana B Santos, Vitor C Pinhanelli, Mayara A R Garcia, Gabriel Silva, Seung J Baek, Suzelei C França, Ana L Fachin, Mozart Marins, Luis O Regasini
In the present study, a series of 2'- and 4'-aminochalcones were synthesized and their antiproliferative activity against a canine malignant histiocytic cell line (DH82) was evaluated. Particularly aminochalcones with a hydrophobic substituent on ring B proved to be potent antiproliferative agents. Among these compounds, aminochalcones 3, 4 and 11 inhibited the growth of DH82 cells, with IC50 values of 34.4, 31.4 and 38.2 μM, respectively, and were three times more potent than etoposide (IC50 = 95.5 μM)...
June 27, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28738246/crocin-modulates-il-4-il-13-signaling-and-ameliorates-experimentally-induced-allergic-airway-asthma-in-a-murine-model
#15
Haidy Yosri, Wagdi F Elkashef, Eman Said, Nariman M Gameil
Allergic asthma is a chronic respiratory disease with a prevalent T helper (Th2)-mediated immune reaction. Crocin, the major bioactive constituent of saffron, has been reported in multiple studies to have numerous pharmacological activities, including prominent anti-oxidant activities. In the current study, the anti-asthmatic potential of crocin was evaluated. Adult male Swiss Albino mice were administered 10mg of ovalbumin (OVA) mixed with 1mg of aluminum hydroxide intraperitoneally on days 0 and 7 and were administered crocin (25mg/kg) orally daily for 16days...
July 21, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28738195/proteomic-and-genetics-insights-on-the-response-of-the-bacteriocinogenic-lactobacillus-sakei-crl1862-during-biofilm-formation-on-stainless-steel-surface-at-10%C3%A2-c
#16
Mariana Pérez-Ibarreche, Lucía M Mendoza, Graciela Vignolo, Silvina Fadda
Some lactic acid bacteria have the ability to form biofilms on food-industry surfaces and this property could be used to control food pathogens colonization. Lactobacillus sakei CR1862 was selected considering its bacteriocinogenic nature and ability to adhere to abiotic surfaces at low temperatures. In this study, the proteome of L. sakei CRL1862 grown either under biofilm on stainless steel surface and planktonic modes of growth at 10°C, was investigated. Using two-dimensional gel electrophoresis, 29 out of 43 statistically significant spots were identified by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry...
July 4, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28737967/integral-membrane-proteins-bottom-up-top-down-and-structural-proteomics
#17
Upendra Karr, Margaret Simonian, Julian P Whitelegge
Integral membrane proteins and lipids constitute the bilayer membranes that surround cells and sub-cellular compartments, and modulate movements of molecules and information between them. Since membrane protein drug targets represent a disproportionately large segment of the proteome, technical developments need timely review. Areas covered and literature search strategy: Publically available resources such as Pubmed were surveyed. Bottom-up proteomics analyses now allow efficient extraction and digestion such that membrane protein coverage is essentially complete, making up around one third of the proteome...
July 24, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28737831/royal-jelly-lipophilic-fraction-induces-antiproliferative-effects-on-sh-sy5y-human-neuroblastoma-cells
#18
Angelo Gismondi, Eleonora Trionfera, Lorena Canuti, Gabriele Di Marco, Antonella Canini
Royal jelly (RJ) is one the most important bee product because it strongly influences the larval development in the hive, including the queen bee. In literature, RJ is known for its antioxidant, immunoregulatory, antifungal, antibiotical, erythropoietic, hypoglycemic, anticholesteremic, antithyroidic, anti-osteoporotic and estrogenic properties. However, it is surprising how rare the scientific evidence about RJ antineoplastic capacity are. That being said, we investigated, for the first time, the in vitro bioactivity of six different RJs on the growth of three different mammalian cell lines: immortalized murine myoblasts (C2C12), human prostate cancer (PC3) and human neuroblastoma (SH-SY5Y)...
July 24, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28737828/taz-inhibition-restores-sensitivity-of-cisplatin-via-akt-mtor-signaling-in-lung-adenocarcinoma
#19
Wei Xu, Yunyan Wei, Yue Li, Yuan Yin, Weiwei Yuan, Yan Yang, Weihong Zhao, Jianqing Wu
The cisplatin-based doublet remains the foundation of treatment for the majority of patients with advanced non-small cell lung cancer (NSCLC), however, many patients exhibit acquired drug resistance. Transcriptional co-activator with PDZ binding motif (TAZ) is an oncogene in lung cancer, important for lung tumorigenesis and metastasis. Recently, it was revealed that TAZ upregulation confers resistance against a diverse range of cytotoxic agents. The present study aimed to investigate whether TAZ is involved in cisplatin sensitivity in lung adenocarcinoma...
July 24, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28737822/liquid-crystal-templating-as-an-approach-to-spatially-and-temporally-organise-soft-matter
#20
REVIEW
Pim van der Asdonk, Paul H J Kouwer
Chemistry quickly moves from a molecular science to a systems science. This requires spatial and temporal control over the organisation of molecules and molecular assemblies. Whilst Nature almost by default (transiently) organises her components at multiple different length scales, scientists struggle to realise even relatively straightforward patterns. In the past decades, supramolecular chemistry has taught us the rules to precisely engineer molecular assembly at the nanometre scale. At higher length scales, however, we are bound to top-down nanotechnology techniques to realise order...
July 24, 2017: Chemical Society Reviews
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