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Larynx carcinoma

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https://www.readbyqxmd.com/read/29673737/epidemiological-features-of-cancers-of-the-oral-cavity-oropharynx-hypopharynx-and-larynx-cancer-in-r%C3%A3-union-island
#1
A Delagranda, G Leterme, E Chirpaz, C Ferdynus, C Fernandez, F Rubin
INTRODUCTION: This study had two objectives: firstly, to identify and compare characteristics of cancer of the oral cavity, oropharynx, hypopharynx and larynx in Réunion Island, a tropical French overseas territory in the southern hemisphere; and secondly, to discuss how incidence of these cancers is presented in the international literature. MATERIAL AND METHOD: A retrospective study included 599 patients diagnosed with cancer of the oral cavity, oropharynx, hypopharynx or larynx between 2009 and 2013 in Réunion Island...
April 16, 2018: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/29671054/survivin-expression-in-head-and-neck-squamous-cell-carcinomas-is-frequent-and-correlates-with-clinical-parameters-and-treatment-outcomes
#2
Adrian Münscher, Sebastian Prochnow, Amit Gulati, Guido Sauter, Balazs Lörincz, Marco Blessmann, Henning Hanken, Arne Böttcher, Till Sebastian Clauditz
OBJECTIVES: Strong expression of survivin is associated with worse survival in many different tumours, and in cell culture, a correlation between radiation resistance and survivin expression can be seen. The potential of survivin expression as a prognostic/predictive marker or therapeutic target has not been examined in head and neck squamous cell carcinomas (HNSCC) yet. MATERIAL AND METHODS: Retrospective study of 452 tissue samples and clinical data from patients with squamous cell carcinomas of the larynx/hypopharynx (LSCC), oral cavity (OSCC) and oropharynx (OPSCC) treated in the University Medical Centre Hamburg-Eppendorf between 2002 and 2006...
April 18, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29670856/cdkn2a-copy-number-loss-is-an-independent-prognostic-factor-in-hpv-negative-head-and-neck-squamous-cell-carcinoma
#3
William S Chen, Ranjit S Bindra, Allen Mo, Thomas Hayman, Zain Husain, Joseph N Contessa, Stephen G Gaffney, Jeffrey P Townsend, James B Yu
Background: HPV infection is associated with high p16 expression and good prognosis in head and neck squamous cell carcinomas (HNSCCs). Analysis of CDKN2A, the gene encoding p16, may further elucidate the association between p16 expression and prognosis. We sought to determine whether CDKN2A copy number loss was associated with poor survival in HPV-negative HNSCCs. Methods: The Cancer Genome Atlas HNSCC clinical and genomic data were obtained and integrated. Patients <80 years old with a primary tumor in the oral cavity, oropharynx, hypopharynx, or larynx were included...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29627048/pathology-of-primary-tracheobronchial-malignancies-other-than-adenoid-cystic-carcinomas
#4
REVIEW
Darroch Moores, Paresh Mane
Most primary tracheal tumors are malignant. Malignancy of larynx and bronchi are much more likely than trachea. Tracheal tumors are most likely due to direct extension for surrounding tumors. Squamous cell carcinoma and adenoid cystic carcinoma make up about two-thirds of adult primary tracheal tumors. Because of their predominantly local growth pattern, malignant salivary gland-type tumors show a better outcome than other histologic types.
May 2018: Thoracic Surgery Clinics
https://www.readbyqxmd.com/read/29623469/role-of-ancillary-techniques-in-profiling-unclassified-laryngeal-malignancies
#5
REVIEW
H Hellquist, J L Hunt, A Cardesa, A Skalova, P J Slootweg, A Rinaldo, A Ferlito
Laryngeal biopsies, contrary to biopsies from many other sites of the body, very often contain minute amounts of tumour tissue that may consist of morphologically undifferentiated tumour only. In haematoxylin- and eosin-stained sections, there may be no indicative features of what specific tumour entity that is present. In the larynx, particularly small round cell neoplasms, primary or metastatic, often cause a diagnostic dilemma and where an incorrect diagnosis can induce substantial clinical consequences for the patient (e...
April 6, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29621382/survival-outcomes-for-patients-with-t3n0m0-squamous-cell-carcinoma-of-the-glottic-larynx-reply
#6
Matthew E Witek, Gregory K Hartig, Paul M Harari
No abstract text is available yet for this article.
April 5, 2018: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29621368/survival-outcomes-for-patients-with-t3n0m0-squamous-cell-carcinoma-of-the-glottic-larynx
#7
Luca D'Ascanio, Fabio Piazza
No abstract text is available yet for this article.
April 5, 2018: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29611770/impact-of-hpv-status-on-the-prognostic-potential-of-the-ajcc-staging-system-for-larynx-cancer
#8
Stacey M Davidson, Huasing C Ko, Paul M Harari, Aaron M Wieland, Shuai Chen, Andrew M Baschnagel, Randall J Kimple, And Matthew E Witek
Objective We evaluated the ability of the American Joint Committee on Cancer (AJCC) seventh edition staging system to prognosticate the overall survival of patients with human papillomavirus (HPV)-positive laryngeal squamous cell carcinoma. Study Design Retrospective analysis. Setting National Cancer Database. Subjects and Methods Patients diagnosed with laryngeal squamous cell carcinoma who were treated with curative intent were identified in the National Cancer Database. Multivariate analysis was utilized to determine factors correlated with overall survival in the HPV-negative and HPV-positive cohorts...
April 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29610957/organ-preservation-surgery-for-patients-with-t4a-laryngeal-cancer
#9
Caiyun Zhang, Minhui Zhu, Donghui Chen, Shicai Chen, Hongliang Zheng
PURPOSE: Surgical preservation of laryngeal function is very challenging in patients with advanced SCCL, especially those of stage T4a. The purpose of this study was to assess the feasibility of organ preservation surgery for patients with T4a squamous cell carcinoma of the larynx (SCCL). METHODS: We enrolled 32 patients with T4a SCCL and performed organ preservation surgery on them. Surgical details and perioperative morbidity were described, functional and oncologic outcomes were also evaluated...
April 2, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29604911/extrinsic-and-intrinsic-apoptotic-responses-induced-by-shiitake-culinary-medicinal-mushroom-lentinus-edodes-agaricomycetes-aqueous-extract-against-a-larynx-carcinoma-cell-line
#10
Tiane C Finimundy, Gustavo Scola, Fernando J Scariot, Aldo J P Dillon, Sidnei Moura, Sérgio Echeverrigaray, João Pegas Henriques, Mariana Roesch-Ely
Cumulative evidence from research studies has shown that the shiitake culinary-medicinal mushroom, Lentinus edodes, is an excellent source of natural antitumor agents and is capable of inhibiting cancer cell growth. However, the cell signaling pathway that leads tumor cells to apoptosis is not well understood because many chemical compounds may be acting. This study investigated the chemopreventive effects of an L. edodes aqueous extract on human HEp-2 epithelial larynx carcinoma cells and normal human MRC-5 lung fibroblasts by identifying proliferative and apoptotic pathways...
2018: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/29598944/three-dimensional-imaging-assessment-of-anatomic-invasion-and-volumetric-considerations-for-chemo-radiotherapy-based-laryngeal-preservation-in-t3-larynx-cancer
#11
Mona Kamal, Sweet Ping Ng, Salman A Eraj, Crosby D Rock, Brian Pham, Jay A Messer, Adam S Garden, William H Morrison, Jack Phan, Steven J Frank, Adel K El-Naggar, Jason M Johnson, Lawrence E Ginsberg, Renata Ferrarotto, Jan S Lewin, Katherine A Hutcheson, Carlos E Cardenas, Mark E Zafereo, Stephen Y Lai, Amy C Hessel, Randal S Weber, G Brandon Gunn, Clifton D Fuller, Abdallah S R Mohamed, David I Rosenthal
OBJECTIVES: To investigate the impact of 3-Diminsional (3D) tumor volume (TV) and extent of involvement of primary tumor on treatment outcomes in a large uniform cohort of T3 laryngeal carcinoma patients treated with nonsurgical laryngeal preservation strategies. MATERIALS AND METHODS: The pretreatment contrast-enhanced computed tomography images of 90 patients with T3 laryngeal carcinoma were reviewed. Primary gross tumor volume (GTVp) was delineated to calculate the 3D TV and define the extent of invasion...
April 2018: Oral Oncology
https://www.readbyqxmd.com/read/29594250/anti-pd-l1-durvalumab-combined-with-cetuximab-and-radiotherapy-in-locally-advanced-squamous-cell-carcinoma-of-the-head-and-neck-a-phase-i-ii-study-ducro
#12
Pierluigi Bonomo, Isacco Desideri, Mauro Loi, Monica Mangoni, Mariangela Sottili, Livia Marrazzo, Cinzia Talamonti, Daniela Greto, Stefania Pallotta, Lorenzo Livi
Introduction and background: Head and neck squamous cell carcinoma (HNSCC) has been increasingly recognized as an immune suppressive malignancy. The efficacy of immune checkpoint inhibitors (ICI's) in the context of recurrent/metastatic (R/M) setting anticipates the possible integration of immunotherapy into the therapeutic armamentarium of locally advanced disease. Durvalumab (DUR) is a humanized monoclonal IgG1, anti-PD-L1 antibody with promising data in R/M HNSCC. The aim of our study is to test the antitumor activity of a combined regimen incorporating an immune checkpoint inhibitor into a conventional bio-radiation strategy for the cure of unfavorable locally advanced HNSCC...
February 2018: Clinical and translational radiation oncology
https://www.readbyqxmd.com/read/29563733/analysis-of-factors-affecting-the-longevity-of-voice-prosthesis-following-total-laryngectomy-with-a-review-of-literature
#13
Arvind Krishnamurthy, Suhaildeen Khwajamohiuddin
Tracheoesophageal voice puncture (TEP) coupled with the use of voice prosthesis has been considered as the gold standard for speech rehabilitation in patients of advanced laryngeal/hypopharyngeal carcinomas, who have undergone a total laryngectomy with or without partial pharyngectomy. Although prosthetic voice rehabilitation is commonly practiced worldwide including India, there is a paucity of published Indian data, more so in the current era of organ conservation. This study included 60 laryngectomized patients with a prosthetic voice rehabilitation at a tertiary cancer center in South India between January 1, 2010 and December 31, 2013...
March 2018: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29563730/clinicopathological-factors-of-cervical-nodal-metastasis-and-the-concept-of-selective-lateral-neck-dissection-in-the-surgical-management-of-carcinoma-larynx-and-hypopharynx-and-its-outcome
#14
Elizabeth Mathew Iype, Santhosh Kumar N, Sreekanth S Kumar, Bipin T Varghese, Jaya C Jose
To study the clinicopathological and molecular factors which correlate with nodal metastasis in laryngeal and hypopharyngeal carcinoma, a retrospective analysis of 170 patients who underwent surgery for laryngeal and hypopharyngeal carcinoma at RCC, Trivandrum from 2006 to 2010 was done. The pathological nodal stage and levels of involvement were correlated with the clinicopathologic features of the primary disease. Neck node positivity was significantly more for lesions of pyriform sinus lesion (61%), with thyroid cartilage erosion (56%) and with base tongue involvement (88%)...
March 2018: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29557536/neuroendocrine-carcinomas-of-the-larynx-and-head-and-neck-challenges-in-classification-and-grading
#15
Bayardo Perez-Ordoñez
Primary neuroendocrine carcinomas (NECs) of the larynx and head and neck are an uncommon and heterogeneous group of neoplasms categorized by the 2017 WHO Classification of Head and Neck Tumors as: (a) well-differentiated (WD-NEC), (b) moderately-differentiated (MD-NEC), and (c) poorly-differentiated (PD-NEC) with small cell and large cell types. The classification incorporates elements of differentiation and grading and closely correlates to the 5-year disease specific survival of 100, 52.8, 19.3 and 15.3% for each diagnostic category...
March 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/29550291/the-role-of-intraoperative-narrow-band-imaging-in-transoral-laser-microsurgery-for-early-and-moderately-advanced-glottic-cancer
#16
Hanna Klimza, Joanna Jackowska, Cesare Piazza, Jacek Banaszewski, Malgorzata Wierzbicka
INTRODUCTION: Trans-oral laser microsurgery is an established technique for the treatment of early and moderately advanced laryngeal cancer. OBJECTIVE: The authors intend to test the usefulness of narrow-band imaging in the intraoperative assessment of the larynx mucosa in terms of specifying surgical margins. METHODS: Forty-four consecutive T1-T2 glottic cancers treated with trans-oral laser microsurgery Type I-VI cordectomy were presented...
March 1, 2018: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29548299/severe-immune-mucositis-and-esophagitis-in-metastatic-squamous-carcinoma-of-the-larynx-associated-with-pembrolizumab
#17
Fanny Zulay Acero Brand, Nicolas Suter, Jean-Philippe Adam, Bernard Faulques, Antonio Maietta, Denis Soulières, Normand Blais
BACKGROUND: Pembrolizumab is an anti-programmed death 1 (PD-1) receptor monoclonal antibody that has shown activity as second line treatment for metastatic head and neck squamous cell carcinoma (HNSCC). Immune-related adverse events are now well described complications of PD-1 inhibitors and most organ sites have been shown to be potentially affected. CASE PRESENTATION: We describe a 69-year old patient with a relapsed squamous cell carcinoma of the supraglottic larynx with lung metastasis after receiving adjuvant concurrent cisplatin and radiotherapy...
March 16, 2018: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/29541239/-prr4-a-novel-downregulated-gene-in-laryngeal-cancer
#18
Seda Ekizoglu, Turgut Ulutin, Jalal Guliyev, Nur Buyru
Head and neck squamous cell carcinomas (HNSCC) are a diverse group of tumor types, including neoplasia of the paranasal sinuses, oral cavity, trachea, pharynx and larynx. Laryngeal cancer is the most common type of HNSCC. The proline-rich 4 (PRR4) protein is synthesized in the acinar cells of human lacrimal glands. Previous studies have demonstrated that PRR4 may function as an antimicrobial protein protecting the ocular surface and the oral cavity. In order to determine differentially expressed genes (DEGs) in laryngeal tumors, a GeneFishing Assay was performed; 27 DEGs were identified...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29538201/salivary-duct-carcinoma-of-the-supraglottis-with-a-distinct-presentation-a-case-report-and-literature-review
#19
Cheng-Chieh Hsu, Wing-Yin Li, Pen-Yuan Chu
RATIONALE: Salivary duct carcinoma (SDC) is a rare and aggressive subtype of salivary gland carcinoma that histologically resembles in situ and invasive ductal carcinoma of the breast. We present the first case of advanced SDC of the minor salivary gland arising from the supraglottis and review the literature on the clinicopathologic characteristics and prognosis of SDC. PATIENT CONCERNS: A 59-year-old male patient with progressive difficulty in swallowing and a muffled voice for 2 months...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29533972/high-notch1-mrna-expression-is-associated-with-better-survival-in-hnscc
#20
Markus Wirth, Daniel Jira, Armin Ott, Guido Piontek, Anja Pickhard
The clinical impact of the expression of NOTCH1 signaling components in squamous cell carcinoma of the pharynx and larynx has only been evaluated in subgroups. The aim of this study was therefore to evaluate NOTCH1 expression in head and neck squamous cell cancer (HNSCC) patient tissue and cell lines. We analyzed tissue from 195 HNSCCs and tissue from 30 normal patients for mRNA expression of NOTCH1, NOTCH3, HES1, HEY1, and JAG1 using quantitative real-time PCR. Association of expression results and clinical orpathological factors was examined with multivariate Cox regression...
March 13, 2018: International Journal of Molecular Sciences
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