keyword
MENU ▼
Read by QxMD icon Read
search

Larynx carcinoma

keyword
https://www.readbyqxmd.com/read/29221167/aggressiveness-pattern-and-second-primary-tumor-risk-associated-with-basaloid-squamous-cell-carcinoma-of-the-larynx
#1
Filippo Ricciardiello, Michele Caraglia, Brigida Iorio, Teresa Abate, Mariarosaria Boccellino, Giuseppe Colella, Flavia Oliva, Pierpaolo Ferrise, Silvia Zappavigna, Mario Faenza, Giuseppe A Ferraro, Giulio Sequino, Giovanni Francesco Nicoletti, Massimo Mesolella
Basaloid squamous cell carcinoma (BSCC) is a rare, aggressive and distinct variant of squamous cell carcinoma (SCC) of the upper respiratory and digestive tract. We have evaluated disease specific survival (DSS) and overall survival (OS) through Kaplan-Meier method and mortality risk through univariate statistical analysis of Cox in 42 cases of BSCC and other 42 of laryngeal SCC (LSCC) matched for both age and sex. We demonstrated that laryngeal BSCC is a more aggressive tumor than LSCC as is associated to higher nodal recurrence of pathology (5 vs 2 patients, overall risk, OR 2...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29212535/leukocytoclastic-vasculitis-complicating-cisplatin-radiation-treatment-for-laryngeal-cancer-a-case-report
#2
Júlia Coelho França Quintanilha, Marília Berlofa Visacri, Laís Sampaio Amaral, Carmen Silvia Passos Lima, Maria Letícia Cintra, Patricia Moriel
BACKGROUND: Leukocytoclastic vasculitis is typically mediated by deposition of immune complexes and is related to many causes, including medication. To the best of our knowledge, leukocytoclastic vasculitis related to cisplatin has not yet been described in the scientific literature. CASE PRESENTATION: We report a rare case of leukocytoclastic vasculitis after the first cycle of high-dose cisplatin chemotherapy in a patient with larynx carcinoma. A 48-year-old Caucasian man with larynx carcinoma received a high-dose of cisplatin monochemotherapy (100 mg/m2 every 21 days), along with 70 Gy of radiotherapy divided into 35 sessions, as a therapeutic schedule...
December 6, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29204101/lymphoepithelial-carcinoma-a-case-report-of-a-rare-tumor-of-the-larynx
#3
Nawal Hammas, Najib Benmansour, Mohamed Nour-Dine El Alami El Amine, Laila Chbani, Hind El Fatemi
Background: Lymphoepithelial carcinoma is a tumor mostly diagnosed in the nasopharynx, but it has also been described in a variety of nonnasopharyngeal sites. It is extremely rare in the larynx and should be distinguished from squamous cell carcinoma. Therefore, it must be known by clinicians, pathologists and oncologists. In this case report, we discuss its etiopathogeny, its epidemiological, clinical, pathological and therapeutic aspects, and its outcome. Case presentation: An 81-year-old Morrocan man, smoker for 40 years, presented with a 1 year history of dysphonia, dyspnea and dysphagia...
2017: BMC Clinical Pathology
https://www.readbyqxmd.com/read/29201783/persistent-elevation-of-ca-19-9-levels-in-the-long-term-follow-up-before-laryngeal-cancer
#4
Hasan Özkan, Fatih Karakaya, Zihni Karaeren, Sibel Perçinel
Introduction: CA 19-9 is used as a tumor marker in colon, pancreas, biliary, and gastric cancers. Laryngeal cancer is the most common malignant epithelial tumor among head and neck cancers and has no specific tumor marker. Case report: A 66-year-old male patient had severe reflux symptoms during 5 years and had an isolated CA 19-9 elevation. Follow-up analysis revealed that he had larynx cancer and after laryngectomy, CA 19-9 levels decreased to normal range. Discussion: Currently, CA 19-9 is not a marker for malignancy...
January 2017: Euroasian Journal of Hepato-Gastroenterology
https://www.readbyqxmd.com/read/29194700/metastatic-laryngeal-large-cell-neuroendocrine-carcinoma-a-rare-case-of-presentation-and-extreme-tumor-burden
#5
Andrew Dunn, Brannon G Broadfoot, Jennifer Hunt, Jennifer R Kaley, Omar Atiq, Narendra Babu Gutta, Xiaofei Wang, Jerad M Gardner, Sara C Shalin
Large cell neuroendocrine carcinoma (LCNEC) of the larynx is an aggressive form of neuroendocrine carcinoma that affects smokers at an average age of 60 years. LCNEC is characterized by large cells with round to ovoid nuclei distributed in a trabecular or nested growth pattern. Previously, laryngeal LCNEC and atypical carcinoid tumors were considered synonymous; however, laryngeal LCNEC has been shown to have higher mitotic rates and worse prognosis, which has led to laryngeal LCNEC to be separated from atypical carcinoid and classified as a poorly differentiated neuroendocrine carcinoma in the most recent World Health Organization classification...
December 1, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29192305/association-of-quantitative-metastatic-lymph-node-burden-with-survival-in-hypopharyngeal-and-laryngeal-cancer
#6
Allen S Ho, Sungjin Kim, Mourad Tighiouart, Cynthia Gudino, Alain Mita, Kevin S Scher, Anna Laury, Ravi Prasad, Stephen L Shiao, Nabilah Ali, Chrysanta Patio, Jon Mallen-St Clair, Jennifer E Van Eyk, Zachary S Zumsteg
Importance: Nodal staging for laryngohypopharyngeal cancers is based primarily on size and laterality, with less value placed on absolute number of metastatic lymph nodes (LNs). We are aware of no studies to date that have specifically addressed the prognostic effect of quantitative nodal burden in larynx or hypopharynx malignancies. Objective: To assess the independent impact of quantitative metastatic LN burden on mortality risk. Design, Setting, and Participants: Univariate and multivariable models were constructed to evaluate the association between patients' number of metastatic LNs and their survival, adjusting for factors such as nodal size, laterality, extranodal extension, margin status, and adjuvant treatment...
November 30, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/29187757/the-role-of-laryngectomy-in-locally-advanced-thyroid-carcinoma-review-of-16-cases
#7
A I Chala, S Vélez, A Sanabria
Locally advanced disease with larynx invasion is a challenge to the surgeon, but laryngectomy is almost never necessary in thyroid carcinoma. The aim of this study was to review the clinical outcomes of patients with locally advanced thyroid carcinoma invading the larynx who underwent laryngectomy. A case series of patients treated in a tertiary care hospital was reviewed. Data about the type of operation, method of reconstruction, complications and overall survival of 16 patients operated on between 2002 and 2015 with larynx invasion is presented...
November 30, 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/29186749/-microvascular-reconstruction-of-the-larynx-following-total-laryngectomy
#8
Stephan Hackenberg, Norbert Kleinsasser, Agmal Scherzad, Fabian Kraus, Rudolf Hagen
Total laryngectomy still is a standard procedure for the treatment of advanced laryngeal or hypopharyngeal carcinoma. The unavoidable loss of voice may lead to serious impairments in quality of life. The most common technique of voice restoration is the tracheal-esophageal puncture combined with the application of a voice prosthesis. Laryngeal reconstruction with a radial forearm flap represents a possible surgical method of voice restoration. This study is a mono-center retrospective analysis of patients receiving a so-called laryngoplasty after total laryngectomy between 2006 and 2015, focusing on long-term functional outcome and complications...
November 29, 2017: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/29181170/role-of-kr%C3%A3-ppel-like-factor-4-and-heat-shock-protein-27-in-cancer-of-the-larynx
#9
Jihad Karam, Marie Claude Fadous-Khalifé, Rita Tannous, Sally Fakhreddine, Marcel Massoud, Joseph Hadchity, Georges Aftimos, Elie Hadchity
Late detection and lack of standard treatment strategies in larynx cancer patients result in high levels of mortality and poor prognosis. Prognostic stratification of larynx cancer patients based on molecular prognostic tumor biomarkers may lead to more efficient clinical management. Krüppel-like factor 4 (KLF4) and Heat Shock Protein 27 (HSP27) have an important role in tumorigenesis and are considered promising candidate biomarkers for various types of cancer. However, their role in larynx carcinoma remains to be elucidated...
November 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29181079/survivin-expression-hpv-positivity-and-microvessel-density-in-oropharyngeal-carcinomas-and-relationship-with-survival-time
#10
Ebru Tastekin, Vuslat Yurut Caloglu, Nilufer Kilic Durankus, Necdet Sut, Gorkem Turkkan, Nuray Can, Fulya Oz Puyan, Murat Caloglu
Introduction: Among head and neck cancers, those of the oral cavity and oropharynx are the second most prevalent following the larynx. This study aimed to research immunohistochemical expression of survivin, HPV positivity and microvessel density in tumors and their relationships with prognosis. Material and methods: Pathological materials and demographic properties of 46 patients were retrospectively evaluated. Survivin, HPV and CD34 (for microvessel density evaluation) antibodies were applied tumoral tissues...
October 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29180076/delineation-of-the-primary-tumour-clinical-target-volumes-ctv-p-in-laryngeal-hypopharyngeal-oropharyngeal-and-oral-cavity-squamous-cell-carcinoma-airo-caca-dahanca-eortc-georcc-gortec-hknpcsg-hncig-iag-kht-lprhht-ncic-ctg-ncri-nrg-oncology-phns-sbrt-somera
#11
Vincent Grégoire, Mererid Evans, Quynh-Thu Le, Jean Bourhis, Volker Budach, Amy Chen, Abraham Eisbruch, Mei Feng, Jordi Giralt, Tejpal Gupta, Marc Hamoir, Juliana K Helito, Chaosu Hu, Keith Hunter, Jorgen Johansen, Johannes Kaanders, Sarbani Ghosh Laskar, Anne Lee, Philippe Maingon, Antti Mäkitie, Francesco Micciche', Piero Nicolai, Brian O'Sullivan, Adela Poitevin, Sandro Porceddu, Krzysztof Składowski, Silke Tribius, John Waldron, Joseph Wee, Min Yao, Sue S Yom, Frank Zimmermann, Cai Grau
PURPOSE: Few studies have reported large inter-observer variations in target volume selection and delineation in patients treated with radiotherapy for head and neck squamous cell carcinoma. Consensus guidelines have been published for the neck nodes (see Grégoire et al., 2003, 2014), but such recommendations are lacking for primary tumour delineation. For the latter, two main schools of thoughts are prevailing, one based on geometric expansion of the Gross Tumour Volume (GTV) as promoted by DAHANCA, and the other one based on anatomical expansion of the GTV using compartmentalization of head and neck anatomy...
November 24, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29178862/prevalence-and-types-of-high-risk-human-papillomaviruses-in-head-and-neck-cancers-from-bangladesh
#12
Mushfiq H Shaikh, Aminul I Khan, Anwar Sadat, Ahmed H Chowdhury, Shahed A Jinnah, Vinod Gopalan, Alfred K Lam, Daniel T W Clarke, Nigel A J McMillan, Newell W Johnson
BACKGROUND: There is a dramatic rise in the incidence of Human papillomavirus (HPV) - associated head and neck squamous cell carcinoma (HNSCC) in the world, with considerable variation by geography, gender and ethnicity. Little is known about the situation in Bangladesh, where tobacco- and areca nut-related head and neck cancers (HNCs) are the most common cancers in men. We aimed to determine the prevalence of HPV in HNSCC in Bangladesh and to explore the possible value of cell cycle markers in clinical diagnostic settings...
November 25, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29176703/nsd1-and-nsd2-damaging-mutations-define-a-subset-of-laryngeal-tumors-with-favorable-prognosis
#13
Suraj Peri, Evgeny Izumchenko, Adrian D Schubert, Michael J Slifker, Karen Ruth, Ilya G Serebriiskii, Theresa Guo, Barbara A Burtness, Ranee Mehra, Eric A Ross, David Sidransky, Erica A Golemis
Squamous cell carcinomas of the head and neck (SCCHN) affect anatomical sites including the oral cavity, nasal cavity, pharynx, and larynx. Laryngeal cancers are characterized by high recurrence and poor overall survival, and currently lack robust molecular prognostic biomarkers for treatment stratification. Using an algorithm for integrative clustering that simultaneously assesses gene expression, somatic mutation, copy number variation, and methylation, we for the first time identify laryngeal cancer subtypes with distinct prognostic outcomes, and differing from the non-prognostic laryngeal subclasses reported by The Cancer Genome Atlas (TCGA)...
November 24, 2017: Nature Communications
https://www.readbyqxmd.com/read/29171929/ahns-series-do-you-know-your-guidelines-principles-of-treatment-for-locally-advanced-or-unresectable-head-and-neck-squamous-cell-carcinoma
#14
Cory D Fulcher, Missak Haigentz, Thomas J Ow
This article is a continuation of the "Do You Know Your Guidelines" series, initiated by the Education committee of the American Head and Neck Society. Treatment guidelines for advanced head and neck squamous cell carcinoma are reviewed here, including the critical roles of radiotherapy, chemotherapy, and the recent application of immunotherapy agents. We will be limiting this discussion to include cancers of the oral cavity, oropharynx, hypopharynx, and larynx. It should be noted that much of the article pertains to human papillomavirus (HPV)-negative oropharyngeal cancer where applicable, as HPV-positive oropharyngeal squamous cell carcinoma carries a different natural history, different prognosis, and now different staging criteria...
November 24, 2017: Head & Neck
https://www.readbyqxmd.com/read/29135311/atm-bcl2-and-tgf%C3%AE-gene-polymorphisms-as-radiotherapy-outcome-biomarkers-in-head-and-neck-squamous-cell-carcinoma-patients
#15
Lidiane P Agostini, Elaine Stur, Fernanda M Garcia, Diego P Ventorim, Raquel S Dos Reis, Raquel S Dettogni, Eldamária V W Dos Santos, Gabriela T Peterle, Lucas L Maia, Suzanny O Mendes, Marcos B de Carvalho, Eloiza H Tajara, Flavia de Paula, Marcelo Dos Santos, Adriana M A da Silva, Iúri Drumond Louro
AIMS: Polymorphisms in cell cycle genes are considered prognostic and radiosensitivity markers in patients with head and neck squamous cell carcinoma. Therefore, we have aimed to investigate the relationship of ATM 5557G>A, ATM IVS62 + 60G>A, TP53 215G>C, BCL2-938C>A, TGFβ-509C>T, and TGFβ 29C>T with radiotherapy response. MATERIALS AND METHODS: Genotyping was performed by polymerase chain reaction followed by restriction fragment length polymorphism in 210 patients with oral cavity/oropharynx carcinoma and 101 patients with larynx tumors...
November 14, 2017: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/29134827/serum-plasma-and-saliva-biomarkers-for-head-and-neck-cancer
#16
Lidia Maria Rebolho Batista Arantes, Ana Carolina de Carvalho, Matias Eliseo Melendez, André Lopes Carvalho
Head and neck squamous cell carcinoma (HNSCC) encompasses tumors arising from several locations (oral and nasal cavities, paranasal sinuses, salivary glands, pharynx, and larynx) and currently stands as the sixth most common cancer worldwide. The most important risk factors identified so far are tobacco and alcohol consumption, and, for a subgroup of HNSCCs, infection with high-risk types of human papillomavirus (HPV). Despite several improvements in the treatment of these tumors in the last decades, overall survival rates have only improved marginally, mainly due to the advanced clinical stage at diagnosis and the high rates of treatment failure associated with this late diagnosis...
November 14, 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/29124912/metastatic-medullary-thyroid-carcinoma-or-calcitonin-secreting-carcinoid-tumor-of-lung-a-diagnostic-dilemma-in-a-patient-with-lung-mass-and-thyroid-nodule
#17
Shifteh Vahidi, Jimmie Stewart, Khalid Amin, Emilian Racila, Faqian Li
Calcitonin-secreting neuroendocrine tumors are rare and have been reported in literature as case reports or case series in various organs including lung, pancreas, larynx, bladder, and ovary. These tumors have similar cytologic features and immunohistochemical profile to medullary thyroid carcinoma and thus it is difficult to distinguish them, especially when calcitonin-secreting neuroendocrine tumors are intermediate or higher grade and there is a mass lesion in the thyroid gland. Here, we report a rare case of calcitonin secreting atypical carcinoid tumor of the lung in a patient with thyroid nodule...
November 10, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29119762/-mortality-study-update-of-workers-exposed-to-vinyl-chloride-in-plants-located-in-ferrara-and-ravenna-emilia-romagna-region-northern-italy
#18
Corrado Scarnato, Rossella Rambaldi, Gianpiero Mancini, Sandra Olanda, Maria Rosa Spagnolo, Elisabetta Previati, Valerio Parmeggiani, Salvatore Minisci, Pietro Comba, Roberta Pirastu
OBJECTIVES: to update the mortality study of subjects exposed to vinyl chloride in the phases of synthesis of the monomer and polymerization in the plants of Ferrara and Ravenna (Emilia-Romagna Region, Northern Italy). DESIGN: both for the whole cohort and for the two plants, standardized mortality ratios (SMRs), with 95% confidence intervals (95%CI), were calculated for different death causes, then stratified by duration and latency, periods of the beginning of work and cumulative exposure (ppm-years)...
September 2017: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/29110635/a-modified-endoscopic-submucosal-dissection-for-a-superficial-hypopharyngeal-cancer-a-case-report-and-technical-discussion
#19
Lianjun Di, Kuang-I Fu, Rui Xie, Xinglong Wu, Youfeng Li, Huichao Wu, Biguang Tuo
BACKGROUND: Adequate working space and a clear view for the dissected lesion are crucial for endoscopic submucosal dissection (ESD). Pharyngeal ESD requires that an otorhinolaryngologist creates working space by lifting the larynx with a curved laryngoscope. However, many countries do not have this kind of curved laryngoscope, and the devices could interfere with endoscope because of the narrow space of the pharynx. To overcome these issues, we used a transparent hood (Elastic Touch, slit and hole type, M (long), Top company, Tokyo Japan) instead of the curved laryngoscope to create adequate working space by pushing the larynx, and pharyngeal ESD could be done by gastroenterologists...
November 6, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29092098/differentiated-and-anaplastic-thyroid-carcinoma-major-changes-in-the-american-joint-committee-on-cancer-eighth-edition-cancer-staging-manual
#20
REVIEW
Nancy D Perrier, James D Brierley, R Michael Tuttle
Answer questions and earn CME/CNE This is a review of the major changes in the American Joint Committee on Cancer staging manual, eighth edition, for differentiated and anaplastic thyroid carcinoma. All patients younger than 55 years have stage I disease unless they have distant metastases, in which case, their disease is stage II. In patients aged 55 years or older, the presence of distant metastases confers stage IVB, while cases without distant metastases are further categorized based on the presence/absence of gross extrathyroidal extension, tumor size, and lymph node status...
November 1, 2017: CA: a Cancer Journal for Clinicians
keyword
keyword
31822
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"