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Larynx carcinoma

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https://www.readbyqxmd.com/read/28640948/high-level-%C3%AE-iii-tubulin-overexpression-occurs-in-most-head-and-neck-cancers-but-is-unrelated-to-clinical-outcome
#1
Julie C Nienstedt, Alexander Gröbe, Till Clauditz, Ronald Simon, Adrian Muenscher, Rainald Knecht, Guido Sauter, Christoph Moebius, Marco Blessmann, Max Heiland, Christina Pflug
BACKGROUND: βIII-tubulin (TUBB3) is an isotype of microtubules, which are involved in crucial cellular roles including maintenance of cell shape, intracellular transport, and mitosis. Overexpression of TUBB3 was found to be associated with poor prognosis and resistance to tubulin-binding drugs and in several solid tumors including head and neck squamous cell carcinomas (HNSCC). Considering the potential high importance of a prognostic biomarker in these cancers, the present study aimed to investigate the clinical relevance of immunohistochemical TUBB3 expression in HNSCC...
June 22, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28635990/neuroendocrine-neoplasms-of-the-head-and-neck-and-olfactory-neuroblastoma-diagnosis-and-classification
#2
S Uccella, G Ottini, C Facco, R Maragliano, S Asioli, F Sessa, S La Rosa
Neuroendocrine neoplasms (NENs) of the head and neck are a rare group of heterogeneous epithelial neoplastic proliferations arising in virtually all of the different organs of this region, particularly in the nasal cavity, the paranasal sinuses, the nasopharynx, the larynx, the salivary glands, and the middle ear. They encompass a wide spectrum of entities ranging from very indolent neuroendocrine tumors to highly aggressive neuroendocrine carcinomas. They may represent a challenge for radiologists, oncologists, and pathologists and a correct diagnosis is crucial for the management of patients...
March 2017: Pathologica
https://www.readbyqxmd.com/read/28627987/computerised-tomography-and-magnetic-resonance-imaging-of-laryngeal-squamous-cell-carcinoma-a-practical-approach
#3
Francesco Agnello, Francesco Cupido, Gianvincenzo Sparacia, Federico Midiri, Martina Miroddi, Emanuele Grassedonio, Massimo Galia
Squamous cell carcinoma is the most common head and neck cancer. This review describes the state-of-the-art computerised tomography and magnetic resonance imaging protocols of the neck and the normal larynx anatomy, and provides a practical approach for the diagnosis and staging of laryngeal squamous cell carcinoma.
June 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28625009/modifications-in-the-treatment-of-advanced-laryngeal-cancer-throughout-the-last-30%C3%A2-years
#4
Jacinto García Lorenzo, Victoria Montoro Martínez, Antonio Rigo Quera, Alberto Codina Aroca, Montserrat López Vilas, Miquel Quer Agustí, Xavier León Vintró
In the last decades, the treatment schemes for patients with locally advanced laryngeal cancer have changed significantly. These changes may have an impact in the survival of these patients. Our objective is to review the treatments administered to patients with locally advanced larynx tumors during a period of 30 years in our institution and to evaluate the prognostic impact of the changes in treatment protocols. Retrospective analysis of a cohort of 830 consecutive patients with T3 or T4 laryngeal carcinomas diagnosed and treated between 1985 and 2014 with a minimum follow-up of 1...
June 17, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28623448/comparison-between-chemoselection-and-definitive-radiotherapy-in-patients-with-cervical-esophageal-squamous-cell-carcinoma
#5
Yusuke Nakata, Nobuhiro Hanai, Daisuke Nishikawa, Hidenori Suzuki, Yusuke Koide, Yujiro Fukuda, Motoo Nomura, Takeshi Kodaira, Takeshi Shimizu, Yasuhisa Hasegawa
BACKGROUD: Laryngeal preservation is an important consideration when treating cervical esophageal cancers (CECs) such as laryngeal cancer. The standard treatment for CEC allowing laryngeal preservation is chemoradiotherapy. However, in cases of laryngeal cancer, chemoselection has also been applied as a treatment strategy that promotes larynx preservation. This strategy involves assigning the appropriate radical treatment according to the primary tumor's response to induction chemotherapy...
June 16, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28608731/survival-outcomes-in-patients-with-t2n0m0-stage-ii-squamous-cell-carcinoma-of-the-larynx
#6
Danielle L Gainor, Emily Marchiano, Emily Bellile, Matthew E Spector, Jeremy M G Taylor, Gregory T Wolf, Norman D Hogikyan, Mark E Prince, Carol R Bradford, Avraham Eisbruch, Francis Worden, Andrew G Shuman
Objective Emerging data have demonstrated suboptimal outcomes among patients with stage II larynx cancer. Our objective is to report survival outcomes for T2N0M0 larynx cancer and to determine the cause-specific survival. Study Design Case series with planned data collection. Setting Tertiary academic center. Subjects Adults with T2N0M0 squamous cell carcinoma of the larynx treated with curative intent. Methods A head and neck cancer epidemiology database was queried for eligible subjects from 2003 to 2014...
June 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28607897/a-comparative-study-of-pharyngeal-repair-in-two-layers-versus-three-layers-following-total-laryngectomy-in-carcinoma-of-larynx
#7
Asok K Saha, Saikat Samaddar, Avijit Choudhury, Abir Chaudhury, Nirmalya Roy
Larynx is the second most common site for cancer in the upper aerodigestive tract. One of the dreaded complications following total laryngectomy has been pharyngo cutaneous fistula (PCF). PCF merits special attention due to its significant negative impact on the recovery process. Total laryngectomy profoundly alters speech. Effective voice restoration is essential for the rehabilitation of these patients. Inadequate consensus exists as to the best technique of pharyngeal repair to decrease incidence of PCF and ensure good quality voice following total laryngectomy...
June 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28605818/-phonomicrosurgery-a-retrospective-analysis-of-400-cases
#8
Rudolf Reiter, Thomas Hoffmann
Introduction Voice disorders caused by pseudotumors of the vocal folds or paralysis of the vocal folds with incomplete glottis closure frequently require phonomicrosurgery. These interventions were analyzed with regard to quality of voice after surgery and safety of the intervention. Methods Retrospective analysis of 400 consecutive phonomicrosurgery interventions. The following parameters were collected: distribution of pathologies of the vocal folds, rating of the voice quality by both the surgeon (RBH-system) and patient and videolaryngstroboscopy six weeks after the intervention compared to the state prior to surgery, complications and results of histological examination...
June 12, 2017: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/28603936/laryngeal-chondrosarcoma-mimicking-medullary-thyroid-carcinoma-on-fine-needle-aspiration-cytology-a-case-report-of-a-diagnostic-pitfall
#9
Shifteh Vahidi, Khalid Amin, Jimmie Stewart
Chondrosarcoma (CS) of larynx is a rare laryngeal tumor accounting about 1% of laryngeal malignancies. When CS arises from thyroid cartilage, it may clinically present as a thyroid nodule. Here we report a rare case of CS of thyroid cartilage misinterpreted as medullary thyroid carcinoma. The main aim of this case report is to emphasize the important role of accurate clinical history, appropriate physical examination, and proper localization of the tumor and clear definitive imaging in conjunction with interpretation of cytologic smears...
June 11, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28602410/adjuvant-chemoradiation-after-surgical-resection-in-elderly-patients-with-high-risk-squamous-cell-carcinoma-of-the-head-and-neck-a-national-cancer-database-analysis
#10
Neil M Woody, Matthew C Ward, Shlomo A Koyfman, Chandana A Reddy, Jessica Geiger, Nikhil Joshi, Brian Burkey, Joseph Scharpf, Eric Lamarre, Brandon Prendes, David J Adelstein
PURPOSE: To determine the patterns of adjuvant chemoradiotherapy use in elderly patients treated with definitive surgical resection for squamous cell carcinoma of the head and neck with extracapsular extension (ECE) or positive margins and determine whether an association with overall survival (OS) exists with adjuvant concurrent chemoradiotherapy (CRT). METHODS AND MATERIALS: The National Cancer Database was queried to identify patients with SCC of the oral cavity, oropharynx, larynx, and hypopharynx who were treated with primary definitive surgery and adjuvant radiation therapy between 2004 and 2012...
July 15, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28592347/management-of-the-thyroid-gland-during-laryngectomy
#11
S X Li, M A Polacco, B J Gosselin, L X Harrington, A J Titus, J A Paydarfar
OBJECTIVES: This study aimed to: describe the incidence of thyroid gland involvement in advanced laryngeal cancer, analyse patterns of spread to the thyroid and elucidate predictors of thyroid involvement. METHODS: A retrospective review was performed on patients who underwent laryngectomy from 1991 to 2015 as a primary or salvage treatment for squamous cell carcinoma of the larynx, hypopharynx or base of tongue. The incidence of thyroidectomy during total laryngectomy, type of thyroidectomy, incidence of gland involvement, route of spread, and positive predictors of spread were analysed and reported...
June 8, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28589113/chondroradionecrosis-of-the-larynx-in-a-patient-with-laryngeal-a-case-report
#12
Aslan Ahmadi, Mohammad Mahdi Salem, Mahdi Safdarian, Shahriar Ilkhani, Roghaieh Hamidian, Mostafa Cheraghipour, Ali Daneshvar, Farzad Izadi
INTRODUCTION: Actinomycosis of the larynx has been rarely reported in the literature and usually occurs in patients with a history of laryngeal carcinoma and radiation therapy. However, its co-existence with chondroradionecrosis due to radiotherapy is even rarer. The most common site of infection is the cervicofacial region, especially in the submandibular area. CASE REPORT: Here we report a 63-year-old male with a history of chemoradiotherapy because of laryngeal cancer 1 year earlier who presented with laryngeal actinomycosis...
May 2017: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28577090/circulating-proteasomes-in-the-pathogenesis-of-head-and-neck-squamous-cell-carcinoma
#13
G V Kakurina, O V Cheremisina, E L Choinzonov, I V Kondakova
Increased proteasome activity was revealed in blood serum of patients with stage T1N0M0 head and neck squamous cell carcinoma in comparison with patients with chronic diseases of the larynx and laryngopharynx. This opens prospects of using chymotrypsin-like activity measurement for differential diagnosis of squamous cell carcinoma, screening for high-risk groups, and evaluation of the degree of tumor differentiation.
June 3, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28559147/gluteus-medius-muscle-metastasis-of-squamous-cell-carcinoma-of-larynx-a-rare-case
#14
Alperen Vural, Deniz Avcı, Sedat Çağlı, İmdat Yüce, Turan Arlı
No abstract text is available yet for this article.
April 29, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28559027/small-cell-carcinoma-of-the-head-and-neck-an-analysis-of-the-national-cancer-database
#15
Kelli B Pointer, Huaising C Ko, Jeffrey V Brower, Matthew E Witek, Randall J Kimple, Ricardo V Lloyd, Paul M Harari, Andrew M Baschnagel
PURPOSE/OBJECTIVE(S): To evaluate treatment trends and overall survival of patients with small cell carcinoma of the head and neck region. MATERIALS/METHODS: Patients from 2004 to 2012 were identified from the National Cancer Database. Patient demographics and overall survival were analyzed. Multivariable analysis was used to identify predictors of survival. RESULTS: Among 347,252 head and neck patients a total of 1042 (0.3%) patients with small cell carcinoma were identified...
June 2017: Oral Oncology
https://www.readbyqxmd.com/read/28558460/-clinic-features-of-laryngeal-carcinosarcoma-and-sarcomatoid-carcinoma
#16
Y J Li, W Y Li, J Wang, Z Q Gao, F Qi, H Jiang
Objective: To investigate the clinic feature, pathology, therapy and prognosis of the sarcomatoid caricinoma or carcinosarcoma of the larynx. Methods: We reviewed the clinical records of 7 patients with laryngeal carcinosarcoma /sarcomatoid caricinoma who were treated at our hospital between June 1996 and August 2016. All patients were men (mean age, 65.9 years; range, 52 to 94 years). Among 7 patients, 6 had a history of smoking; 2 underwent radiotherapy; and 5 patients who didn't undergo radiotherapy complained of hoarseness...
May 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28551677/serum-levels-of-igf-1-and-igfbp-3-in-relation-to-clinical-and-pathobiological-aspects-of-head-and-neck-squamous-cell-carcinomas
#17
David Kalfert, Marie Ludvikova, Ondrej Topolcan, Petr Celakovsky, Radek Kucera, Jindra Windrichova, Jaroslav Ludvik, Katerina Skalova, Vlastimil Kulda, Martin Pesta, Jan Plzak
BACKGROUND/AIM: Head and neck squamous cell carcinoma (HNSCC) includes tumors of various anatomical sites sharing multifactorial etiopathogenesis and generally dismal response to conventional treatment. The objective of this study was to determine the clinical significance of serum levels of insulin-like growth factor-1 (IGF-1) and insulin-like growth factor-binding protein-3 (IGFBP-3) in HNSCC. PATIENTS AND METHODS: A total of 46 patients, with histologically-confirmed diagnosis of HNSCC (21 oropharyngeal, 21 laryngeal, and 4 hypopharyngeal cancers) were enrolled in this study...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28546727/huge-carcinosarcoma-of-the-endolarynx-a-rare-tumour-with-unusual-presentation
#18
Rakesh Kumar Singh, Richi Sinha, Anju Singh, Sanjay Suman, Madhu Priya
Carcinosarcoma or sarcomatoid carcinoma is a highly malignant variant of squamous cell carcinoma, which comprises 2 to 3 % of all laryngeal cancer. It is considered to be a biphasic tumour, composed of a squamous cell carcinoma (in situ or invasive) and spindle cell carcinoma with sarcomatous appearance. We present a case of huge carcinosarcoma of larynx in a 34 year-old male who developed severe stridor and dysphagia. The diagnosis was confirmed histopathologically, hence the disease was treated through total laryngectomy followed by adjuvant chemotherapy and radiotherapy...
June 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28530265/papillary-squamous-cell-carcinoma-of-the-palatine-tonsil-a-rare-cancer-of-the-head-and-neck
#19
A Serra, R Caltabiano, G Scalia, S Palmucci, P Di Mauro, S Cocuzza
Papillary squamous neoplasms of the upper respiratory tract are rare variants of squamous cell carcinomas. They are characterised by an exophytic, papillary growth and generally have favourable prognosis. The tumour has been described in the upper aerodigestive tract. In this context, most common sites of involvement are the larynx and hypopharynx, and rarely the oral cavity and oropharynx. The limited studies and small number of published cases of papillary squamous cell carcinoma of the palatine tonsil led us to make a complete analysis of this tumour by analysing the clinical, histological, radiological, virological and therapeutic aspects that are not always present in the literature...
May 22, 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28496456/swallowing-disorders-after-oral-cavity-and-pharyngolaryngeal-surgery-and-role-of-imaging
#20
REVIEW
Caterina Giannitto, Lorenzo Preda, Valeria Zurlo, Luigi Funicelli, Mohssen Ansarin, Salvatore Di Pietro, Massimo Bellomi
Head and neck squamous cell carcinoma is the sixth most common cancer diagnosed worldwide and the eighth most common cause of cancer death. Malignant tumors of the oral cavity, oropharynx, and larynx can be treated by surgical resection or radiotheraphy with or without chemotheraphy and have a profound impact on quality of life functions, including swallowing. When surgery is the chosen treatment modality, the patient may experience swallowing impairment in the oral and pharyngeal phases of deglutition. A videofluoroscopic study of swallow enables the morphodynamics of the pharyngeal-esophageal tract to be accurately examined in patients with prior surgery...
2017: Gastroenterology Research and Practice
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