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https://www.readbyqxmd.com/read/28098161/modelling-of-occupational-exposure-to-inhalable-nickel-compounds
#1
Benjamin Kendzia, Beate Pesch, Dorothea Koppisch, Rainer Van Gelder, Katrin Pitzke, Wolfgang Zschiesche, Thomas Behrens, Tobias Weiss, Jack Siemiatycki, Jerome Lavoué, Karl-Heinz Jöckel, Roger Stamm, Thomas Brüning
The aim of this study was to estimate average occupational exposure to inhalable nickel (Ni) using the German exposure database MEGA. This database contains 8052 personal measurements of Ni collected between 1990 and 2009 in adjunct with information on the measurement and workplace conditions. The median of all Ni concentrations was 9 μg/m(3) and the 95th percentile was 460 μg/m(3). We predicted geometric means (GMs) for welders and other occupations centered to 1999. Exposure to Ni in welders is strongly influenced by the welding process applied and the Ni content of the used welding materials...
January 18, 2017: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/28097598/influence-of-doping-and-nanostructuration-on-n-type-bi2-te0-8se0-2-3-alloys-synthesized-by-arc-melting
#2
Mouna Gharsallah, Federico Serrano-Sanchez, Norbert M Nemes, Jose Luis Martinez, Jose Antonio Alonso
In competitive thermoelectric devices for energy conversion and generation, high-efficiency materials of both n-type and p-type are required. For this, Bi2Te3-based alloys have the best thermoelectric properties in room temperature applications. Partial replacement of tellurium by selenium is expected to introduce new donor states in the band gap, which would alter electrical conductivity and thermopower. We report on the preparation of n-type Bi2(Te1-xSex)3 solid solutions by a straightforward arc-melting technique, yielding nanostructured polycrystalline pellets...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28096421/rfamide-related-peptide-3-rfrp-3-suppresses-sexual-maturation-in-a-eusocial-mammal
#3
Diana E Peragine, Martha Pokarowski, Lucia Mendoza-Viveros, Ashlyn Swift-Gallant, Hai-Ying M Cheng, George E Bentley, Melissa M Holmes
Neuroendocrine mechanisms underlying social inhibition of puberty are not well understood. Here, we use a model exhibiting the most profound case of pubertal suppression among mammals to explore a role for RFamide-related peptide-3 [RFRP-3; mammalian ortholog to gonadotropin-inhibitory hormone (GnIH)] in neuroendocrine control of reproductive development. Naked mole rats (NMRs) live in sizable colonies where breeding is monopolized by two to four dominant animals, and no other members exhibit signs of puberty throughout their lives unless they are removed from the colony...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28096345/the-nbs-lrr-architectures-of-plant-r-proteins-and-metazoan-nlrs-evolved-in-independent-events
#4
Jonathan M Urbach, Frederick M Ausubel
There are intriguing parallels between plants and animals, with respect to the structures of their innate immune receptors, that suggest universal principles of innate immunity. The cytosolic nucleotide binding site-leucine rich repeat (NBS-LRR) resistance proteins of plants (R-proteins) and the so-called NOD-like receptors of animals (NLRs) share a domain architecture that includes a STAND (signal transduction ATPases with numerous domains) family NTPase followed by a series of LRRs, suggesting inheritance from a common ancestor with that architecture...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28094520/synthesis-crystal-structure-magnetic-properties-and-stability-of-the-manganese-rich-mn3alc-%C3%AE%C2%BA-phase
#5
Hannes Dierkes, Jan van Leusen, Dimitri Bogdanovski, Richard Dronskowski
κ-carbides of varying composition, seemingly responsible for age hardening in high-Al steel alloys, have been detected to precipitate both at grain boundaries and in the bulk grain of steels. Herein we report the bulk-phase synthesis of "Mn3AlC" by arc plasma sintering and rapid solidification. Single crystals have been found suitable for X-ray diffraction using Mo radiation and yield a lattice parameter of a = 3.875(2) Å. We find a mixed occupation of the 1a position by Al and Mn, which, together with the C position being fully occupied, leads to the actual composition Mn3...
January 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28092615/immunoreactivity-of-arcuate-nucleus-astrocytes-in-rats-after-intragastric-administration-of-habanero-peppers-capsicum-chinese-jacq
#6
K Rycerz, A Krawczyk, J Jaworska-Adamu, M Gołyński, K Lutnicki, I Balicki
Habanero pepper fruits contain capsaicin (CAP) characterised by a spicy taste. Astrocytes express vanilloid receptor (TRPV1), which interacts with cannabinoids including CAP. Only a few studies revealed that CAP leads to alterations of the arcuate nucleus (ARC) structures. The aim of this study was to analyse the GFAP (GFAP-IR) and S100β (S100β-IR) immunoreactive astrocytes of ARC in adult rats after intragastric administration of habanero pepper fruits. Adult, Wistar rats received a peanut oil - control group (C) - and oil suspension of habanero pepper fruits at a dose of 0...
December 1, 2016: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/28092346/differential-hypothalamic-leptin-sensitivity-in-obese-rat-offspring-exposed-to-maternal-and-postnatal-intake-of-chocolate-and-soft-drink
#7
M Kjaergaard, C Nilsson, A Secher, J Kildegaard, T Skovgaard, M O Nielsen, K Grove, K Raun
BACKGROUND/OBJECTIVE: Intake of high-energy foods and maternal nutrient overload increases the risk of metabolic diseases in the progeny such as obesity and diabetes. We hypothesized that maternal and postnatal intake of chocolate and soft drink will affect leptin sensitivity and hypothalamic astrocyte morphology in adult rat offspring. METHODS: Pregnant Sprague-Dawley rats were fed ad libitum chow diet only (C) or with chocolate and high sucrose soft drink supplement (S)...
January 16, 2017: Nutrition & Diabetes
https://www.readbyqxmd.com/read/28092337/anatomical-basis-and-clinical-application-of-synovial-flaps-in-the-wrist-and-distal-forearm
#8
David L Colen, Jiun-Ting Yeh, Lawrence B Colen
Neuropathic symptoms after median nerve repair at the wrist or secondary to refractory carpal tunnel syndrome may become debilitating. These symptoms develop due to perineural adhesions, intraneural fibrosis and fixation of the nerve to the transverse carpal ligament after surgery and often require neurolysis. Interposition of vascularized soft tissue over the median nerve at the time of neurolysis prevents recurrence of such adhesions. The synovial flap, fashioned from the synovial lining of the flexor tendon sheath, is an ideal tissue for this purpose...
January 12, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28089825/clinical-and-radiographic-outcome-of-revision-surgery-of-total-elbow-prosthesis-midterm-results-in-19-cases
#9
Jetske Viveen, Ante Prkic, Koen L M Koenraadt, Izaäk F Kodde, Bertram The, Denise Eygendaal
BACKGROUND: The aim of this study is to report on the midterm outcomes and complications of revision surgery of total elbow arthroplasty. METHODS: All patients who had undergone total elbow arthroplasty revision surgery between 2009 and 2014 with semiconstrained total elbow prostheses were prospectively enrolled in the study. Records were reviewed for demographic data; baseline measurements; and several follow-up assessments including the Mayo Elbow Performance Score (MEPS), visual analog scale (VAS) score for pain, Oxford Elbow Score, range of motion, satisfaction, and radiographs...
January 13, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28089479/estimation-of-radiation-induced-secondary-cancer-risks-for-early-stage-non-small-cell-lung-cancer-patients-after-stereotactic-body-radiation-therapy
#10
Chunhui Han, Timothy E Schultheiss, Jeffrey Y C Wong
PURPOSE: In this study, we evaluated radiation-induced secondary lung cancer risks for the lung and the breast from stereotactic body radiation therapy treatment of early-stage non-small cell lung cancer with different radiation therapy treatment modalities. METHODS AND MATERIALS: Ten patients (5 men and 5 women) with early-stage non-small cell lung cancer who received definitive stereotactic body radiation therapy treatments were retrospectively selected. For each patient, two 3-dimensional conformal radiation therapy (3D-CRT) plans using 6- and 10-MV photons, respectively; a helical tomotherapy (HT) plan; and 2 volumetric modulated arc therapy (VMAT) plans using 1 and 2 arcs, respectively, were generated...
October 19, 2016: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28088966/-delayed-hematologic-response-to-immunosuppressive-therapy-in-severe-aplastic-anemia
#11
Y Yang, W R Yang, Z J Wu, X Zhao, L Zhang, L P Jing, K Zhou, Y Li, G X Peng, Y Li, J P Li, L Song, L Ye, H H Fan, F K Zhang
Objective: To explore the characteristics of delayed hematologic response in very/severe aplastic anemia (V/SAA) patients who were treated with immunosuppressive treatment (IST) as first-line approach, and investigate the rationality of early salvage treatment in refractory patients. Methods: The data of V/SAA patients front-line treated with IST were retrospectively analyzed. Delayed response was defined as acquiring hematologic response between 6 and 12 months after 1 course of IST. The clinical as well as hematologic characteristics of the delayed responded patients were investigated...
December 14, 2016: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/28088762/the-super-n-motifs-model-a-novel-alignment-free-approach-for-representing-and-comparing-rna-secondary-structures
#12
Jean-Pierre Séhi Glouzon, Jean-Pierre Perreault, Shengrui Wang
MOTIVATION: Comparing ribonucleic acid (RNA) secondary structures of arbitrary size uncovers structural patterns that can provide a better understanding of RNA functions. However, performing fast and accurate secondary structure comparisons is challenging when we take into account the RNA configuration (i.e. linear or circular), the presence of pseudoknot and G-quadruplex (G4) motifs and the increasing number of secondary structures generated by high-throughput probing techniques. To address this challenge, we propose the super-n-motifs model based on a latent analysis of enhanced motifs comprising not only basic motifs but also adjacency relations...
January 14, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28088468/hypothalamic-effects-of-thyroid-hormone
#13
Zhi Zhang, Anita Boelen, Peter H Bisschop, Andries Kalsbeek, Eric Fliers
Thyroid hormone (TH) is a key driver of metabolism in mammals. Plasma concentrations of TH are kept within a narrow range by negative feedback regulation in the hypothalamus-pituitary-thyroid (HPT) axis. Plasma TH concentrations are an important determinant of metabolic processes in liver and brown adipose tissue (BAT). In addition to endocrine effects of TH derived from the circulation, recent studies have demonstrated additional neural routes for intrahypothalamic thyroid hormone to regulate metabolism in liver and BAT via the sympathetic and parasympathetic branch of the autonomic nervous system (ANS)...
January 11, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28088216/immunohistochemical-features-of-giant-cell-ependymoma-of-the-filum-terminale-with-unusual-clinical-and-radiological-presentation
#14
Fernando Candanedo-Gonzalez, Cindy Sharon Ortiz-Arce, Samuel Rosales-Perez, Ana Lilia Remirez-Castellanos, Candelaria Cordova-Uscanga, Armando Gamboa-Dominguez
BACKGROUND: Giant cell ependymoma of the filum terminale is a rare variant, generally manifested as a well-circunscribed intradural mass with an indolent biological behavior. CASE PRESENTATION: We describe the case of a 48-year-old Mexican female who non-relevant past medical history, that developed a GCE of the filum terminale. Magnetic resonance imaging and computed tomography revealed the presence of an intra-axial tumor extending from L3 to L5 with extra-medullary invasion...
January 14, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28087336/oleate-induces-katp-channel-dependent-hyperpolarisation-in-mouse-hypothalamic-glucose-excited-neurones-without-altering-cellular-energy-charge
#15
Selma Dadak, Craig Beall, Julia M Vlachaki Walker, Marc Pm Soutar, Rory J McCrimmon, Michael L J Ashford
The unsaturated fatty acid, oleate exhibits anorexigenic properties reducing food intake and hepatic glucose output. However, its mechanism of action in the hypothalamus has not been fully determined. This study investigated the effects of oleate and glucose on GT1-7 mouse hypothalamic cells (a model of glucose-excited (GE) neurones) and mouse arcuate nucleus (ARC) neurones. Whole-cell and perforated patch-clamp recordings, immunoblotting and cell energy status measures were used to investigate oleate and glucose sensing properties of mouse hypothalamic neurones...
January 9, 2017: Neuroscience
https://www.readbyqxmd.com/read/28087103/identifying-methanogen-community-structures-and-their-correlations-with-performance-parameters-in-four-full-scale-anaerobic-sludge-digesters
#16
Taewoan Koo, Seung Gu Shin, Joonyeob Lee, Gyuseong Han, Woong Kim, Kyungjin Cho, Seokhwan Hwang
Four full-scale mesophilic anaerobic digesters treating waste sludge were monitored to characterize methanogen communities and their relationship with process parameters. The performance of the four digesters were dissimilar with the average chemical oxygen demand removal efficiencies between 24 and 45% and differing pH. Real-time quantitative PCR showed that archaeal 16S rRNA gene concentration ([ARC]) and, more pronouncedly, its ratio to bacterial counterpart ([ARC]/[BAC]) correlated positively with the performance parameters, including the lipid removal efficiency...
January 4, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28079260/an-experimentally-validated-couch-and-mlc-tracking-simulator-used-to-investigate-hybrid-couch-mlc-tracking
#17
Jakob Toftegaard, Rune Hansen, Thomas Ravkilde, Kristijan Macek, Per Rugaard Poulsen
PURPOSE/OBJECTIVE: Couch and MLC tracking are two novel techniques to mitigate intrafractional tumor motion on a conventional linear accelerator, but both techniques still have residual dosimetric errors. Here, we first propose and experimentally validate a software tool to simulate couch and MLC tracking, and then use the simulator to study hybrid couch-MLC tracking for improved tracking performance. MATERIALS AND METHODS: The tracking simulator requires a treatment plan and a motion trajectory as input and simulates the delivered monitor units and motion of all accelerator parts as function of time...
January 12, 2017: Medical Physics
https://www.readbyqxmd.com/read/28079160/tempo-of-magma-degassing-and-the-genesis-of-porphyry-copper-deposits
#18
Cyril Chelle-Michou, Bertrand Rottier, Luca Caricchi, Guy Simpson
Porphyry deposits are copper-rich orebodies formed by precipitation of metal sulphides from hydrothermal fluids released from magmatic intrusions that cooled at depth within the Earth's crust. Finding new porphyry deposits is essential because they are our largest source of copper and they also contain other strategic metals including gold and molybdenum. However, the discovery of giant porphyry deposits is hindered by a lack of understanding of the factors governing their size. Here, we use thermal modelling and statistical simulations to quantify the tempo and the chemistry of fluids released from cooling magmatic systems...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28078542/glenoid-baseplate-fixation-using-hybrid-configurations-of-locked-and-unlocked-peripheral-screws
#19
Nathan T Formaini, Nathan G Everding, Jonathan C Levy, Brandon G Santoni, Aniruddh N Nayak, Cooper Wilson
BACKGROUND: The use of peripheral locked screws has reduced glenoid baseplate failure rates in reverse shoulder arthroplasty. However, situations may arise when one or more non-locked screws may be preferred. We aimed to determine if different combinations of locked and non-locked screws significantly alter acute glenoid baseplate fixation in a laboratory setting. MATERIALS AND METHODS: Twenty-eight polyurethane trabecular bone surrogates were instrumented with a center screw-type glenoid baseplate and fixated with various combinations of peripheral locked and non-locked screws (1-, 2-, 3- and 4-locked con)...
January 11, 2017: Journal of Orthopaedics and Traumatology: Official Journal of the Italian Society of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/28077128/treatment-planning-comparison-of-impt-vmat-and-4%C3%AF-radiotherapy-for-prostate-cases
#20
Angelia Tran, Jingjing Zhang, Kaley Woods, Victoria Yu, Dan Nguyen, Gary Gustafson, Lane Rosen, Ke Sheng
BACKGROUND: Intensity-modulated proton therapy (IMPT), non-coplanar 4π intensity-modulated radiation therapy (IMRT), and volumetric-modulated arc therapy (VMAT) represent the most advanced treatment methods based on heavy ion and X-rays, respectively. Here we compare their performance for prostate cancer treatment. METHODS: Ten prostate patients were planned using IMPT with robustness optimization, VMAT, and 4π to an initial dose of 54 Gy to a clinical target volume (CTV) that encompassed the prostate and seminal vesicles, then a boost prescription dose of 25...
January 11, 2017: Radiation Oncology
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