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https://www.readbyqxmd.com/read/28723867/prediction-of-severe-toxicity-in-adult-patients-under-treatment-with-5-fluorouracil-a-prospective-cohort-study
#1
Carolina Vázquez, María Orlova, Federico Angriman, José N Minatta, Paula Scibona, María A Verzura, Esteban G Jáuregui, Heidy Díaz de Arce, María G Pallotta, Waldo H Belloso
5-Fluorouracil (5-FU) has long been used for the treatment of gastrointestinal tumors harboring interindividual variability in both the pharmacokinetic and the pharmacogenetic profiles, which in turn may lead to life-threatening toxicities. We carried out a prospective cohort study of adult patients initiating treatment with 5-FU between 2013 and 2015. Primary exposures of interest were the methylenetetrahydrofolate reductase single nucleotide polymorphism in exons 4 and 7 and 5'-untranslated region-thymidylate synthase VNTR genotypes, in addition to baseline clinical and demographic variables...
July 18, 2017: Anti-cancer Drugs
https://www.readbyqxmd.com/read/28721601/high-survivorship-and-few-complications-with-cementless-total-wrist-arthroplasty-at-a-mean-followup-of-9-years
#2
Joseph A Gil, Robin N Kamal, Eugene Cone, Arnold-Peter C Weiss
BACKGROUND: Total wrist arthroplasty (TWA) has been described as traditionally being performed with fixation in the radius and carpus with cement. The TWA implant used in our series has been associated with promising results in studies with up to 6 years followup; however, studies evaluating survivorship, pain, and function with this implant are limited. QUESTION/PURPOSE: (1) To report ROM and pain scores after wrist reconstruction with cementless fourth-generation TWA at a mean followup of 9 years (range, 4...
July 18, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28721330/truebeam-radiosurgery-for-the-treatment-of-trigeminal-neuralgia-preliminary-results-at-a-single-institution
#3
Mena G Kerolus, Neilayan Sen, Sonal Mayekar, Alistar Templeton, Julius Turian, Aidnag Diaz, Lorenzo Munoz, Richard W Byrne, Sepehr Sani
INTRODUCTION: Radiosurgery is now an established method of satisfactory pain control in patients with trigeminal neuralgia (TN). The Varian Truebeam STx (Varian Medical Systems, Palo Alto, CA) linear accelerator (LINAC) system is an arc-based, frameless stereotactic radiosurgery system used for the treatment of TN. To our knowledge, there has been only one published series of patient histories that documents the use of a frameless LINAC system for the treatment of TN. We describe the treatment parameters, patient outcomes, and complications associated with the treatment of TN...
June 16, 2017: Curēus
https://www.readbyqxmd.com/read/28721044/stimulated-phase-shift-acoustic-nanodroplets-enhance-vancomycin-efficacy-against-methicillin-resistant-staphylococcus-aureus-biofilms
#4
Hao Guo, Ziming Wang, Quanyin Du, Pan Li, Zhigang Wang, Aimin Wang
PURPOSE: Bacterial biofilms on the surface of prostheses are becoming a rising concern in managing prosthetic joint infections. The inherent resistant features of biofilms render traditional antimicrobial therapy unproductive and revision surgery outcomes uncertain. This situation has prompted the exploration of novel antimicrobial strategies. The synergy of ultrasound microbubbles and vancomycin has been proposed as an efficient alternative for biofilm eradication. The purpose of this study was to evaluate the anti-biofilm effect of stimulated phase-shift acoustic nanodroplets (NDs) combined with vancomycin...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28720786/a-few-enlarged-chloroplasts-are-less-efficient-in-photosynthesis-than-a-large-population-of-small-chloroplasts-in-arabidopsis-thaliana
#5
Dongliang Xiong, Jianliang Huang, Shaobing Peng, Yong Li
The photosynthetic, biochemical, and anatomical traits of accumulation and replication of chloroplasts (arc) mutants of Arabidopsis thaliana were investigated to study the effects of chloroplast size and number on photosynthesis. Chloroplasts were found to be significantly larger, and the chloroplast surface area exposed to intercellular air spaces (S c) significantly lower in the mutants than in their wild-types. The decreased S c and increase cytoplasm thickness in the mutants resulted in a lower mesophyll conductance (g m) and a consequently lower chloroplast CO2 concentration (C c)...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28720047/ring-avulsion-injuries-a-systematic-review
#6
Ravinder Bamba, Gautam Malhotra, Reuben A Bueno, Wesley P Thayer, R Bruce Shack
BACKGROUND: Ring avulsion injuries can range from soft tissue injury to complete amputation. Grading systems have been developed to guide treatment, but there is controversy with high-grade injuries. Traditionally, advanced ring injuries have been treated with completion amputation, but there is evidence that severe ring injuries can be salvaged. The purpose of this systematic review was to pool the current published data on ring injuries. METHODS: A systematic review of the English literature published from 1980 to 2015 in PubMed and MEDLINE databases was conducted to identify patients who underwent treatment for ring avulsion injuries...
February 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28720007/extensor-pollicis-brevis-spiral-tenodesis-for-combined-metacarpophalangeal-instability-and-trapeziometacarpal-arthritis
#7
Mark Henry
BACKGROUND: In more advanced stages of trapeziometacarpal arthritis, the thumb metacarpal may develop an adduction contracture, leading to secondary hyperextension instability of the metacarpophalangeal joint. Following trapeziometacarpal arthroplasty, uncorrected substantial metacarpophalangeal hyperextension may contribute to ongoing Z-collapse deformity, weakness of pinch and grip, and patient perception of diminished function. METHODS: We prospectively analyzed a consecutive case series of 55 trapeziometacarpal arthroplasty patients (mean age, 60 years; 7 males) who received simultaneous extensor pollicis brevis spiral tenodesis for thumb metacarpophalangeal hyperextension of at least 50°...
March 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28719937/a-challenging-case-of-giant-biliary-stones-in-a-patient-with-situs-inversus-totalis-conventional-ercp-combined-with-intraductal-cholangioscopy-and-laser-lithotripsy
#8
Félix I Téllez-Ávila, Sandeep Pattel, Gilberto Duarte-Medrano, Marlon Seenath, David R Herrera-Mora, Gustavo Lopez-Arce
No abstract text is available yet for this article.
July 18, 2017: Endoscopy
https://www.readbyqxmd.com/read/28718329/assessment-of-forearm-rotational-control-using-4-upper-extremity-immobilization-constructs
#9
Ayesha M Rahman, Nicole Montero-Lopez, Richard M Hinds, Michael Gottschalk, Eitan Melamed, John T Capo
BACKGROUND: Forearm immobilization techniques are commonly used to manage distal radius, scaphoid, and metacarpal fractures. The purpose of our study was to compare the degree of rotational immobilization provided by a sugar-tong splint (STS), short arm cast (SAC), Munster cast (MC), and long arm cast (LAC) at the level of the distal radioulnar joint (DRUJ), carpus, and metacarpals. METHODS: Seven cadaveric upper extremity specimens were mounted to a custom jig with the ulnohumeral joint fixated in 90° of flexion...
February 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28716957/ampa-receptors-control-fear-extinction-through-an-arc-dependent-mechanism
#10
Simon Trent, Philip Barnes, Jeremy Hall, Kerrie L Thomas
Activity-regulated cytoskeleton-associated protein (Arc) supports fear memory through synaptic plasticity events requiring actin cytoskeleton rearrangements. We have previously shown that reducing hippocampal Arc levels through antisense knockdown leads to the premature extinction of contextual fear. Here we show that the AMPA receptor antagonist CNQX elevates hippocampal Arc levels during extinction and blocks extinction that can be rescued by reducing Arc. Increasing Arc levels with CNQX also overcomes the actin-destabilizing properties of cytochalasin D and promotes extinction...
August 2017: Learning & Memory
https://www.readbyqxmd.com/read/28716382/combined-elbow-release-and-humeral-rotational-osteotomy-in-arthrogryposis
#11
Rey N Ramirez, Christopher J Richards, Scott H Kozin, Dan A Zlotolow
PURPOSE: The purpose of this study was to determine if a simultaneous posterior elbow release and humeral osteotomy to correct both the elbow extension contracture and the humeral internal rotation contracture in children with arthrogryposis can produce similar results as a posterior elbow release alone. METHODS: This study was a retrospective chart review of consecutive patients with arthrogryposis treated surgically for elbow extension contracture between 2007 and 2014...
July 14, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28716058/srf-modulates-seizure-occurrence-activity-induced-gene-transcription-and-hippocampal-circuit-reorganization-in-the-mouse-pilocarpine-epilepsy-model
#12
Pascal Lösing, Cristina Elena Niturad, Merle Harrer, Christopher Meyer Zu Reckendorf, Theresa Schatz, Daniela Sinske, Holger Lerche, Snezana Maljevic, Bernd Knöll
A hallmark of temporal lobe epilepsy (TLE) is hippocampal neuronal demise and aberrant mossy fiber sprouting. In addition, unrestrained neuronal activity in TLE patients induces gene expression including immediate early genes (IEGs) such as Fos and Egr1.We employed the mouse pilocarpine model to analyze the transcription factor (TF) serum response factor (SRF) in epileptogenesis, seizure induced histopathology and IEG induction. SRF is a neuronal activity regulated TF stimulating IEG expression as well as nerve fiber growth and guidance...
July 17, 2017: Molecular Brain
https://www.readbyqxmd.com/read/28715415/characterizing-the-malaria-rural-to-urban-transmission-interface-the-importance-of-reactive-case-detection
#13
Karen Molina Gómez, M Alejandra Caicedo, Alexandra Gaitán, Manuela Herrera-Varela, María Isabel Arce, Andrés F Vallejo, Julio Padilla, Pablo Chaparro, M Andreína Pacheco, Ananias A Escalante, Myriam Arevalo-Herrera, Sócrates Herrera Valencia
BACKGROUND: Reported urban malaria cases are increasing in Latin America, however, evidence of such trend remains insufficient. Here, we propose an integrated approach that allows characterizing malaria transmission at the rural-to-urban interface by combining epidemiological, entomological, and parasite genotyping methods. METHODS/PRINCIPAL FINDINGS: A descriptive study that combines active (ACD), passive (PCD), and reactive (RCD) case detection was performed in urban and peri-urban neighborhoods of Quibdó, Colombia...
July 17, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28714067/evaluation-of-plastic-scintillator-detector-for-small-field-stereotactic-patient-specific-quality-assurance
#14
Yujiao Qin, Stephen J Gardner, Joshua Kim, Yimei Huang, Ning Wen, Anthony Doemer, Indrin J Chetty
PURPOSE: To evaluate the performance of a commercial plastic scintillator detector (PSD) for small-field stereotactic patient-specific quality assurance (QA) measurements using flattening-filter-free beam. METHODS: A total of ten spherical targets (volume range: [0.03cc-2cc]) were planned with two techniques: (1) Dynamic Conformal Arc (DCA-10 plans), and (2) Volumetric Modulated Arc Therapy (VMAT-10 plans). All plans were generated using Varian Eclipse treatment planning system, and AcurosXB v...
July 17, 2017: Medical Physics
https://www.readbyqxmd.com/read/28713251/age-related-changes-in-lateral-entorhinal-and-ca3-neuron-allocation-predict-poor-performance-on-object-discrimination
#15
Andrew P Maurer, Sarah A Johnson, Abbi R Hernandez, Jordan Reasor, Daniela M Cossio, Kaeli E Fertal, Jack M Mizell, Katelyn N Lubke, Benjamin J Clark, Sara N Burke
Age-related memory deficits correlate with dysfunction in the CA3 subregion of the hippocampus, which includes both hyperactivity and overly rigid activity patterns. While changes in intrinsic membrane currents and interneuron alterations are involved in this process, it is not known whether alterations in afferent input to CA3 also contribute. Neurons in layer II of the lateral entorhinal cortex (LEC) project directly to CA3 through the perforant path, but no data are available regarding the effects of advanced age on LEC activity and whether these activity patterns update in response to environmental change...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/28712954/social-media-platforms-and-heart-failure
#16
R Jay Widmer, Makala K Arce, Lee A Aase, Farris K Timimi
With the pervasive use of the internet and social media, the potential applicability toward patients with heart failure (HF) remains understudied. Here, we outline the general use of social media and some early work utilizing social media as well as data from our own Mayo Clinic Center for Social Media experience. Both enterprise-wide social media data as well as those specific to HF-related pages and posts appear to support the preferential use of Facebook and YouTube for potential benefit in patients with HF...
July 13, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28712931/genome-wide-association-study-reveals-that-the-aquaporin-nip1-1-contributes-to-variation-in-hydrogen-peroxide-sensitivity-in-arabidopsis-thaliana
#17
Ayan Sadhukhan, Yuriko Kobayashi, Yuki Nakano, Satoshi Iuchi, Masatomo Kobayashi, Lingaraj Sahoo, Hiroyuki Koyama
Hydrogen peroxide (H2O2) is a reactive oxygen species that affects cell signaling in various plant defense responses, and induces programmed cell death. To identify the new components associated with H2O2 signaling and tolerance, we conducted a genome-wide association study (GWAS) on the root growth of 133 Arabidopsis thaliana accessions grown in the presence of toxic H2O2 levels. The most significant SNPs were associated with a cluster of chromosome 4 genes encoding an aquaporin NODULIN 26-LIKE INTRINSIC PROTEIN 1;1 (NIP1;1), an NB-ARC domain-containing disease resistance protein (AT4G19050), and a putative membrane lipoprotein (AT4G19070)...
July 13, 2017: Molecular Plant
https://www.readbyqxmd.com/read/28712715/split-vmat-technique-to-control-the-expiratory-breath-hold-time-in-liver-stereotactic-body-radiation-therapy
#18
Yen Hwa Lin, Shuichi Ozawa, Hideharu Miura, Katsunori Yogo, Takeo Nakashima, Kentaro Miki, Shintaro Tsuda, Yusuke Ochi, Daisuke Kawahara, Tomoki Kimura, Akito Saito, Yasushi Nagata
PURPOSE: In this study, we demonstrate the feasibility of using split-arcs in volumetric modulated arc therapy (VMAT), tailored for expiratory breath-hold in stereotactic body radiation therapy (SBRT) for liver tumors. We compare it with three-dimensional conformal radiation therapy (3D-CRT) and continuous-VMAT, for ten randomly selected hepatocellular carcinoma cases. METHODS: Four coplanar and four non-coplanar beams were used for the 3D-CRT plans. A pair of partial arcs, chosen using a back-and-forth rotating motion, were used for the continuous-VMAT plans...
July 13, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28712028/internal-femoral-component-rotation-adversely-influences-load-transfer-in-total-knee-arthroplasty-a-cadaveric-navigated-study-using-the-verasense-device
#19
William A Manning, Kanishka M Ghosh, Alasdair Blain, Lee Longstaff, Steven P Rushton, David J Deehan
PURPOSE AND HYPOTHESIS: Correct femoral component rotation at knee arthroplasty influences patellar tracking and may determine function at extremes of movement. Additionally, such malrotation may deleteriously influence flexion/extension gap geometry and soft tissue balancing kinematics. Little is known about the effect of subtle rotational change upon load transfer across the tibiofemoral articulation. Our null hypothesis was that femoral component rotation would not influence load across this joint in predictable manner...
July 15, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28711481/simultaneous-integrated-boost-sib-for-treatment-of-gynecologic-carcinoma-intensity-modulated-radiation-therapy-imrt-vs-volumetric-modulated-arc-therapy-vmat-radiotherapy
#20
Irina Vergalasova, Kim Light, Junzo Chino, Oana Craciunescu
The aim of this study was to quantitatively compare dosimetric criteria between intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT) plans for patients undergoing radiation treatment of gynecologic carcinoma with a simultaneous integrated boost (SIB) technique. IMRT and VMAT plans were retrospectively analyzed for 20 patients. The elective volume was planned to receive 45 Gy in 25 fractions of 1.8 Gy, with the integrated boost volume (involved nodes) receiving 55 Gy simultaneously...
July 12, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
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