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https://www.readbyqxmd.com/read/29243666/electric-field-tuned-mos2-metal-interface-for-hydrogen-evolution-catalyst-from-first-principles-investigations
#1
F L Ling, T W Zhou, X Q Liu, W Kang, W Zeng, Y X Zhang, L Fang, Y Lu, M Zhou
Understanding the interfacial properties of catalyst/substrate is crucial for the design of high-performance catalyst for important chemical reactions. Recent years have witnessed a surge of research in utilizing MoS2 as a promising electro-catalyst for hydrogen production, and field effect has been employed to enhance the activity (Wang et al 2017 Adv. Mater. 29, 1604464; Yan et al 2017 Nano Lett. 17, 4109-15). However, the underlying atomic mechanism remains unclear. In this paper, by using the prototype MoS2/Au system as a probe, we investigate effects of external electric field on the interfacial electronic structures via density functional theory (DFT) based first-principles calculations...
December 15, 2017: Nanotechnology
https://www.readbyqxmd.com/read/29239916/early-experience-with-clinimacs-prodigy-ccs-ifn-gamma-system-in-selection-of-virus-specific-t-cells-from-third-party-donors-for-pediatric-patients-with-severe-viral-infections-after-hematopoietic-stem-cell-transplantation
#2
Krisztián Kállay, Csaba Kassa, Marienn Réti, Éva Karászi, János Sinkó, Vera Goda, Anita Stréhn, Katalin Csordás, Orsolya Horváth, Attila Szederjesi, Szabolcs Tasnády, Apor Hardi, Gergely Kriván
Viral reactivation is a frequent complication of allogeneic hematopoietic stem cell transplantation especially in children. For refractory cases, rapid virus-specific T-cell therapy would be ideally implemented within a few days. Over the course of a year in our pediatric cohort of 43 allogeneic transplantation, 9 patients fulfilled criteria for virus-specific T-cell therapy. Viral infections were due to cytomegalovirus (CMV) in 3, Epstein-Barr virus (EBV) in 2, and adenovirus (AdV) in 1 case, whereas >1 virus was detected in 3 cases...
December 12, 2017: Journal of Immunotherapy
https://www.readbyqxmd.com/read/29227494/the-crucial-role-of-a-spacer-material-on-the-efficiency-of-charge-transfer-processes-in-organic-donor-acceptor-junction-solar-cells
#3
Reed Nieman, Hsinhan Tsai, Wanyi Nie, Adelia J A Aquino, Aditya D Mohite, Sergei Tretiak, Hao Li, Hans Lischka
Organic photovoltaic donor-acceptor junction devices composed of π-conjugated polymer electron donors (D) and fullerene electron acceptors (A) show greatly increased performance when a spacer material is inserted between the two layers (W. Y. Nie, G. Gupta, B. K. Crone, F. L. Liu, D. L. Smith, P. P. Ruden, C. Y. Kuo, H. Tsai, H. L. Wang, H. Li, S. Tretiak and A. D. Mohite, Adv. Sci., 2015, 2, 1500024.). For instance, experimental results reveal significant improvement of photocurrent when a terthiophene oligomer derivative is inserted in between π-conjugated poly(3-hexylthiophene-2,5-diyl) (P3HT) donor and C60 acceptor...
December 11, 2017: Nanoscale
https://www.readbyqxmd.com/read/29227008/ice-or-fire-comparison-of-second-generation-cryoballoon-ablation-and-radiofrequency-ablation-in-patients-with-symptomatic-persistent-atrial-fibrillation-and-an-enlarged-left-atrium
#4
Ersan Akkaya, Alexander Berkowitsch, Sergej Zaltsberg, Harald Greiss, Christian W Hamm, Johannes Sperzel, Thomas Neumann, Malte Kuniss
INTRODUCTION: We aimed to compare arrhythmia recurrence rates after second-generation cryoballoon (CB-Adv) ablation and radiofrequency (RF) ablation in patients with symptomatic persistent atrial fibrillation (AF) and left atrial (LA) enlargement. METHODS AND RESULTS: Persistent AF patients with LA enlargement were compared using a propensity-score-matching algorithm, and 111 patients treated with CB-Adv ablation and 111 patients treated with RF ablation were selected...
December 11, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29192893/electric-field-tuned-mos-sub-2-sub-metal-interface-for-hydrogen-evolution-catalyst-from-first-principles-investigations
#5
Faling Ling, Tingwei Zhou, Xiaoqing Liu, Wei Kang, Wen Zeng, Yixin Zhang, L Fang, Yi Lu, Miao Zhou
Understanding the interfacial properties of catalyst/substrate is crucial for the design of high-performance catalyst for important chemical reactions. Recent years have witnessed a surge of research in utilizing MoS2 as a promising electro-catalyst for hydrogen production, and field effect has been employed to enhance the activity (Adv. Mater. 2017, 29, 1604464; Nano Lett. 2017, 17, 4109). However, the underlying atomic mechanism remains unclear. In this paper, by using the prototype MoS2/Au system as a probe, we investigate effects of external electric field on the interfacial electronic structures via density functional theory (DFT) based first-principles calculations...
December 1, 2017: Nanotechnology
https://www.readbyqxmd.com/read/29182907/evaluation-of-the-suitability-of-a-plant-virus-pepper-mild-mottle-virus-as-a-surrogate-of-human-enteric-viruses-for-assessment-of-the-efficacy-of-coagulation-rapid-sand-filtration-to-remove-those-viruses
#6
N Shirasaki, T Matsushita, Y Matsui, R Yamashita
Here, we evaluated the removal of three representative human enteric viruses - adenovirus (AdV) type 40, coxsackievirus (CV) B5, and hepatitis A virus (HAV) IB - and one surrogate of human caliciviruses - murine norovirus (MNV) type 1 - by coagulation-rapid sand filtration, using water samples from eight water sources for drinking water treatment plants in Japan. The removal ratios of a plant virus (pepper mild mottle virus; PMMoV) and two bacteriophages (MS2 and φX174) were compared with the removal ratios of human enteric viruses to assess the suitability of PMMoV, MS2, and φX174 as surrogates for human enteric viruses...
November 21, 2017: Water Research
https://www.readbyqxmd.com/read/29174380/effect-of-heme-oxygenase-1-on-the-protection-of-ischemia-reperfusion-injury-of-bile-duct-in-rats-after-liver-transplantation
#7
Xi Zhan, Zhiqing Zhang, Hanfei Huang, Yujun Zhang, Zhong Zeng
OBJECTIVE: To investigate the effect of heme oxygenase-1 (HO-1) on the ischemic reperfusion injury (IRI) of bile duct in rat models after liver transplantation. METHODS: 320 SD rats were equally and randomly divided into 5 groups, which were group A receiving injection of 3×108/pfu/ml adenovirus (adv), group B with donor receiving Adv-HO-1 and recipient receiving Adv-HO-1-siRNA, group C with donor and recipient both receiving Adv-HO-1, group D with donor receiving Adv-HO-1-siRNA and recipient receiving Adv-HO-1, and group E with donor and recipient both receiving Adv-HO-1-siRNA at 24h before liver transplantation...
November 21, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29163524/t-helper-17-promotes-induction-of-antigen-specific-gut-mucosal-cytotoxic-t-lymphocytes-following-adenovirus-vector-vaccination
#8
Masahisa Hemmi, Masashi Tachibana, Natsuki Fujimoto, Masaki Shoji, Fuminori Sakurai, Kouji Kobiyama, Ken J Ishii, Shizuo Akira, Hiroyuki Mizuguchi
Few current vaccines can establish antigen (Ag)-specific immune responses in both mucosal and systemic compartments. Therefore, development of vaccines providing defense against diverse infectious agents in both compartments is of high priority in global health. Intramuscular vaccination of an adenovirus vector (Adv) has been shown to induce Ag-specific cytotoxic T lymphocytes (CTLs) in both systemic and gut-mucosal compartments. We previously found that type I interferon (IFN) signaling is required for induction of gut-mucosal, but not systemic, CTLs following vaccination; however, the molecular mechanism involving type I IFN signaling remains unknown...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29159014/erratum-transition-metal-carbides-and-nitrides-in-energy-storage-and-conversion
#9
Yu Zhong, Xinhui Xia, Fan Shi, Jiye Zhan, Jiangping Tu, Hong Jin Fan
[This corrects the article DOI: 10.1002/advs.201500286.].
March 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/29151700/tenofovir-vs-lamivudine-plus-adefovir-in-chronic-hepatitis-b-tenosimp-b-study
#10
Manuel Rodríguez, Juan Manuel Pascasio, Enrique Fraga, Javier Fuentes, Martín Prieto, Gloria Sánchez-Antolín, José Luis Calleja, Esther Molina, María Luisa García-Buey, María Ángeles Blanco, Javier Salmerón, María Lucía Bonet, José Antonio Pons, José Manuel González, Miguel Ángel Casado, Francisco Jorquera, The Tenosimp-B Research Group
AIM: To demonstrate the non-inferiority (15% non-inferiority limit) of monotherapy with tenofovir disoproxil fumarate (TDF) vs the combination of lamivudine (LAM) plus adefovir dipivoxil (ADV) in the maintenance of virologic response in patients with chronic hepatitis B (CHB) and prior failure with LAM. METHODS: This study was a Phase IV prospective, randomized, open, controlled study with 2 parallel groups (TDF and LAM+ADV) of adult patients with hepatitis B e antigen (HBeAg)-negative CHB, prior failure with LAM, on treatment with LAM+ADV for at least 6 mo, without prior resistance to ADV and with an undetectable viral load at the start of the study, in 14 Spanish hospitals...
November 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29119303/evolution-of-drug-resistant-mutations-in-hbv-genomes-in-patients-with-treatment-failure-during-the-past-seven-years-2010-2016
#11
Hong-Yu Zhang, Long-Gen Liu, Chun-Yan Ye, Chun-Hua Chen, Shuang-Xiong Hang, Zhen Zhu, Hong-Yu Shen, Ze-Yu Huang, Wen-Yi Chen, Yuan Xue
The objective of this study was to analyze the prevalence of drug-resistant HBV mutants in patients with treatment failure during the past seven years (2010-2016). 4055 HBV-infected patients who underwent HBV polymerase gene mutation test from 2010 to 2016 were enrolled. The nucleos(t)ide analogues (NAs) resistance mutation positions, including rtL180, rtA181, rtT184, rtS202, rtM204, rtI233, rtN236, rtI169, rtV173, and rtM250 were analyzed. Genotypic resistance mutations were detected in 30.8% (1248/4055) of the patients with treatment failure...
November 8, 2017: Virus Genes
https://www.readbyqxmd.com/read/29095799/comparing-efficacy-of-lamivudine-adefovir-dipivoxil-telbivudine-and-entecavir-in-treating-nucleoside-analogues-na%C3%A3-ve-for-hbeag-negative-hepatitis-b-with-medium-hepatitis-b-virus-hbv-dna-levels
#12
Hong Shi, Zongping Han, Jian Liu, Jinfang Xue, Shuya Zhang, Zhe Zhu, Jinyu Xia, Mingxing Huang
BACKGROUND The antiviral effect of HBV in different nucleos (t) ide analogues is still not well known. This study was conducted to compare the effectiveness of lamivudine (LMV), adefovir dipivoxil (ADV), telbivudine (LdT), and entecavir (ETV) monotherapy in chronic HBeAg-negative hepatitis B patients with medium load of HBV DNA. MATERIAL AND METHODS The effective data of 207 patients treated by LMV (n=43), ADV (n=57), LdT (n=54) or ETV (n=53) were collected and analyzed during 144-week follow-up by retrospective analysis...
November 2, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29082645/efficacy-and-safety-of-three-adefovir-based-combination-therapies-in-hbeag-positive-chronic-hepatitis-b-patients-with-suboptimal-response-to-adefovir-monotherapy
#13
M-L Wang, E-Q Chen, D-M Zhang, L-Y Du, L-B Yan, T-Y Zhou, X-Z Lei, B-J Lei, J-J Lu, J Liao, H Tang
Although high potent nucleos(t)ide analogues are strongly recommended as first-line therapy for chronic hepatitis B (CHB) in China, some patients are still being treated with adefovir disoproxil (ADV), especially those low-income patients whose health insurance could not reimburse the drug cost. Therefore, the management of patients who have failed ADV therapy or who sustained renal damage during ADV therapy remains an important clinical problem in China. This retrospective study aimed to compare the efficacy and safety of lamivudine (LAM), telbivudine (LdT) or entecavir (ETV) add-on strategies to optimize the treatment of patients with prior suboptimal response to ADV monotherapy...
November 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29071400/microbial-electrosynthesis-i-pure-and-defined-mixed-culture-engineering
#14
Miriam A Rosenbaum, Carola Berger, Simone Schmitz, Ronny Uhlig
In the past 6 years, microbial bioelectrochemistry has strongly increased in attraction and audience when expanding from mainly environmental technology applications to biotechnology. In particular, the promise to combine electrosynthesis with microbial catalysis opens attractive approaches for new sustainable redox-cofactor recycling, redox-balancing, or even biosynthesis processes. Much of this promise is still not fulfilled, but it has opened and fueled entirely new research areas in this discipline. Activities in designing, tailoring, and applying specific microbial catalysts as pure or defined co-cultures for defined target bioproductions are greatly accelerating...
October 26, 2017: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/29068349/evaluation-of-virus-recovery-methods-and-efficiency-of-tannin-derived-coagulants-in-removing-total-coliforms-e-coli-and-enteric-viruses-in-effluents-of-a-domestic-sewage-treatment-plant
#15
Rafael Bandeira Fabres, Roger Bordin da Luz, Mayra Cristina Soliman, Rodrigo Staggemeier, Juliane Deise Fleck, Carlos Augusto do Nascimento, Felipe Tiago do Nascimento, Fernando Rosado Spilki
In the present study, nine coagulants having potential to be used for sewage treatment were compared to assess their efficiency in removing total coliform bacteria, Escherichia coli and adenovirus. The coagulants tested were metallic and organic and their efficiency was compared when treating samples of raw and treated sewage (activated sludge). Before the efficiency tests of the coagulants, viral concentration methods were compared. Coagulation tests were carried out by using the jar-test system and the doses used ranged from 100 ppm to 1,000 ppm...
October 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29051754/a-cellular-fusion-cascade-regulated-by-laea-is-required-for-sclerotial-development-in-aspergillus-flavus
#16
Xixi Zhao, Joseph E Spraker, Jin Woo Bok, Thomas Velk, Zhu-Mei He, Nancy P Keller
Aspergillus flavus is a saprophytic soil fungus that poses a serious threat worldwide as it contaminates many food and feed crops with the carcinogenic mycotoxin called aflatoxin. This pathogen persists as sclerotia in the soil which enables fungal survival in harsh environmental conditions. Sclerotia formation by A. flavus depends on successful cell communication and hyphal fusion events. Loss of LaeA, a conserved developmental regulator in fungi, abolishes sclerotia formation in this species whereas overexpression (OE) of laeA results in enhanced sclerotia production...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29046843/intercalation-of-si-between-mos2-layers
#17
Rik van Bremen, Qirong Yao, Soumya Banerjee, Deniz Cakir, Nuri Oncel, Harold J W Zandvliet
We report a combined experimental and theoretical study of the growth of sub-monolayer amounts of silicon (Si) on molybdenum disulfide (MoS2). At room temperature and low deposition rates we have found compelling evidence that the deposited Si atoms intercalate between the MoS2 layers. Our evidence relies on several experimental observations: (1) Upon the deposition of Si on pristine MoS2 the morphology of the surface transforms from a smooth surface to a hill-and-valley surface. The lattice constant of the hill-and-valley structure amounts to 3...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/29023803/hbeag-levels-at-week-24-predict-response-to-8%C3%A2-years-of-tenofovir-in-hbeag-positive-chronic-hepatitis-b-patients
#18
D Wong, M Littlejohn, L Yuen, K Jackson, H Mason, J Bayliss, G Rosenberg, A Gaggar, K Kitrinos, M Subramanian, P Marcellin, M Buti, H L A Janssen, E Gane, S Locarnini, A Thompson, P A Revill
BACKGROUND: Hepatitis B e antigen (HBeAg) seroconversion is a treatment endpoint for HBeAg-positive CHB, and a necessary precursor to HBsAg loss. Biomarkers that predict serological outcomes would be useful. AIM: To evaluate the utility of measuring HBeAg levels for predicting HBeAg seroconversion and HBsAg loss under long-term tenofovir (TDF) therapy. METHODS: A total of 266 patients were enrolled into a phase III study of TDF vs adefovir (ADV) for 48 weeks in HBeAg-positive patients, followed by open-label TDF up to 384 weeks...
October 11, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29020844/nucleoside-nucleotide-analogues-in-the-treatment-of-chronic-hepatitis-b-infection-during-pregnancy-a-systematic-review
#19
Soheil Tavakolpour, Mohammad Darvishi, Hajar Sadat Mirsafaei, Mojtaba Ghasemiadl
BACKGROUND: Women of childbearing age who have developed chronic hepatitis B (CHB) infection, especially HBeAg-positive highly viraemic pregnant women, are largely responsible for the familial transmission of the infection. Therefore, choosing the most effective and safest antiviral medications to manage pregnant CHB patients is of crucial importance. MATERIALS AND METHODS: The PubMed and Scopus databases were searched through September 2017, for all the journal articles possessing original results regarding treatment of CHB pregnant women with any nucleos(t)ide analogue (NA) therapies, including lamivudine (LAM), adefovir (ADV), entecavir (ETV), telbivudine (LdT), and tenofovir (TDF)...
October 11, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/29020348/kinetics-of-double-stranded-dna-viremia-after-allogeneic-hematopoietic-cell-transplantation
#20
Joshua A Hill, Bryan T Mayer, Hu Xie, Wendy M Leisenring, Meei-Li Huang, Terry Stevens-Ayers, Filippo Milano, Colleen Delaney, Keith R Jerome, Danielle M Zerr, Garrett Nichols, Michael Boeckh, Joshua T Schiffer
Background: Improved understanding of double stranded DNA (dsDNA) virus kinetics after hematopoietic cell transplantation (HCT) would facilitate development of therapeutic strategies. Methods: We tested weekly plasma samples from 404 patients through day 100 after allogeneic HCT for cytomegalovirus (CMV), human herpesvirus 6B (HHV-6B), HHV-6A, BK polyomavirus (BKV), adenovirus (AdV), and Epstein-Barr virus (EBV) using quantitative PCR. Episodes lasting ≤1 week were defined as blips and >1 week as persistent...
September 9, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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