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https://www.readbyqxmd.com/read/28704440/viral-etiology-seasonality-and-severity-of-hospitalized-patients-with-severe-acute-respiratory-infections-in-the-eastern-mediterranean-region-2007-2014
#1
Katherine C Horton, Erica L Dueger, Amr Kandeel, Mohamed Abdallat, Amani El-Kholy, Salah Al-Awaidy, Abdul Hakim Kohlani, Hanaa Amer, Abel Latif El-Khal, Mayar Said, Brent House, Guillermo Pimentel, Maha Talaat
INTRODUCTION: Little is known about the role of viral respiratory pathogens in the etiology, seasonality or severity of severe acute respiratory infections (SARI) in the Eastern Mediterranean Region. METHODS: Sentinel surveillance for SARI was conducted from December 2007 through February 2014 at 20 hospitals in Egypt, Jordan, Oman, Qatar and Yemen. Nasopharyngeal and oropharyngeal swabs were collected from hospitalized patients meeting SARI case definitions and were analyzed for infection with influenza, respiratory syncytial virus (RSV), adenovirus (AdV), human metapneumovirus (hMPV) and human parainfluenza virus types 1-3 (hPIV1-3)...
2017: PloS One
https://www.readbyqxmd.com/read/28685288/a-red-squirrel-associated-adenovirus-identified-by-a-combined-microarray-and-deep-sequencing-approach
#2
Björn Abendroth, Dirk Höper, Rainer G Ulrich, Gudrun Larres, Martin Beer
In 2013, an adult red squirrel (Sciurus vulgaris) was found dead showing, during necropsy, acute diffuse catarrhal enteritis. Using a virus screening pipeline based on a pan-viral DNA microarray with downstream next-generation sequencing a novel squirrel-associated virus was identified with mastadenovirus-typical sequence elements. Phylogenetic analysis of hexon protein amino acid sequences demonstrated the highest similarity to Equine adenovirus (AdV) 2, but a strong divergence to a squirrel AdV from Korea and other rodent AdVs...
July 6, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28685200/role-of-the-burden-of-premature-atrial-contractions-during-the-blanking-period-following-second-generation-cryoballoon-ablation-in-predicting-late-recurrences-of-atrial-arrhythmias
#3
Hugo-Enrique Coutiño, Juan-Pablo Abugattas, Moisés Levinstein, Giacomo Mugnai, Darragh Moran, Valentina De Regibus, Erwin Ströker, Ken Takarada, Rajin Choudhury, Luis Marroquín, Francesca Salghetti, Ian-Emiray Lusoc, Saverio Iacopino, Juan Sieira, Carlo de Asmundis, Pedro Brugada, Gian-Battista Chierchia
PURPOSE: Recent data suggests that high burden of premature atrial complexes after pulmonary vein isolation predicts recurrences of atrial arrhythmias. The present study sought to assess the role of premature atrial complexes burden in predicting atrial arrhythmias recurrences in patients with atrial fibrillation (AF) who have undergone second-generation cryoballoon ablation (CB-Adv). METHODS: Consecutive patients with drug-resistant paroxysmal atrial fibrillation who underwent pulmonary vein isolation using CB-Adv technology as the index procedure were retrospectively included...
July 6, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/28685004/a-newborn-with-an-alternative-porto-caval-shunt
#4
Çağrı Damar, Ayşe Gül Alımlı, Betül Emine Derinkuyu, Kudret Ebru Özcan, Asburçe Olgaç, Ali Murat Koç
BACKGROUND: Absent ductus venosus (ADV) is a rare condition, but it should be known that this embryonic anomaly may be detected by fetal echocardiographic or newborn ultrasound examinations. CASE REPORT: We present a baby with an ADV and an accompanying alternative porto-caval shunt between the right portal vein and inferior vena cava detected on postnatal ultrasound examination. CONCLUSIONS: Variations in the fetal umbilical or porto-systemic circulations should be detected by fetal or newborn ultrasound examinations and kept in mind before common interventions such as UV catheterizations...
2017: Polish Journal of Radiology
https://www.readbyqxmd.com/read/28678147/efficacy-of-second-generation-cryoballoon-ablation-in-paroxysmal-and-persistent-atrial-fibrillation-patients
#5
Antonio Curnis, Francesca Salghetti, Manuel Cerini, Francesca Vassanelli, Lorenza Inama, Clara Villa, Daniele Giacopelli, Abdallah Raweh, Luca Bontempi
AIMS: In this study, we aimed to compare the efficacy of single pulmonary vein isolation with the second-generation cryoballoon (CB-Adv) and predictors of atrial fibrillation recurrences in patients with paroxysmal (PAF) and persistent atrial fibrillation (PersAF). METHODS: Consecutive PAF and PersAF patients undergoing CB-Adv for the first time were enrolled. Patients were followed with in-clinic visits including Holter ECG. Atrial arrhythmic episodes symptomatic or documented lasting more than 30 s were considered as recurrences...
July 3, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/28672964/the-effects-and-possible-mechanism-of-%C3%AE-2ar-gene-expression-in-cardiocytes-of-canines-with-heart-failure
#6
Haibin Gong, Yu San, Lei Wang, Qian Lv, Libin Chen
The objective of the present study was to observe the changes of β2-adrenergic receptor (β2AR) protein expression in a canine model of heart failure (HF), and the function of cardiocytes after transfection with Adv-β2AR. The canine model of chronic HF was induced by rapid right ventricular pacing and cardiocytes were isolated with collagenase II. Cardiocytes were transfected with Adv-β2AR to observe contractile function with a motion edge-detection system of single cells. Expression of β2AR protein in cardiocytes was measured by immunoblotting and the levels of intracellular cAMP were measured by ELISA...
July 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28672949/long-term-adefovir-therapy-may-induce-fanconi-syndrome-a-report-of-four-cases
#7
Fan Pan, Yingchao Wang, Xin Zhang, Qingfeng Lin, Xiaolong Liu, Yi Jiang, Chen Pan
Fanconi syndrome is a rare disease characterized by dysfunction of the proximal renal tubules as a result of various pathogenic events. Drug-induced Fanconi syndrome may be neglected or misdiagnosed, which increases the level of suffering. The aim of the present study was to conduct an investigation into the effects of adefovir (ADV)-induced Fanconi syndrome. Four typical cases of Fanconi syndrome caused by long-term ADV therapy (2-9 years) were diagnosed at our hospital. A complete medical and therapy history was collected from all four patients prior to a physical examination...
July 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28668490/co-infections-by-double-stranded-dna-dsdna-viruses-after-ex-vivo-t-cell-depleted-cd34-selected-hematopoietic-cell-transplantation-hct
#8
Yao-Ting Huang, Seong Jin Kim, Yeon Joo Lee, Daniel Burack, Paige Nichols, Molly Maloy, Miguel-Angel Perales, Sergio A Giralt, Ann A Jakubowski, Genovefa A Papanicolaou
Recipients of ex vivo T-cell depleted (TCD) HCT are at risk of infection by double stranded (ds) DNA viruses. We report rates of dsDNA viremia, end-organ disease (EOD), infection-related mortality, and overall survival (OS) in a contemporary cohort of adult TCD HCT recipients routinely monitored for cytomegalovirus (CMV), adenovirus (ADV), human herpesvirus 6 (HHV6) and Epstein-Barr virus (EBV). Health care utilization in the first 6 months post HCT was compared between patients with dsDNA viremia versus no viremia...
June 28, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28661410/approach-to-adenovirus-infections-in-the-setting-of-hematopoietic-cell-transplantation
#9
Yeon Joo Lee, Susan E Prockop, Genovefa A Papanicolaou
PURPOSE OF REVIEW: To review risk-based pre-emptive treatment for adenovirus (ADV) based on quantitative PCR (qPCR) and to provide an update on clinical trials of brincidofovir (BCV) and ADV-specific cytotoxic T lymphocytes (ADV-CTLs). RECENT FINDINGS: ADV qPCR in various body compartments enables distinction of clinically significant infection and assessment of treatment responses. Plasma ADV qPCR monitoring and aggressive pre-emptive treatment is recommended for high-risk patients...
August 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/28654938/numerical-study-of-bubble-area-evolution-during-acoustic-droplet-vaporization-enhanced-hifu-treatment
#10
Ying Xin, Aili Zhang, Lisa X Xu, J Brian Fowlkes
Acoustic droplet vaporization has the potential to shorten treatment time of high-intensity focused ultrasound (HIFU) while minimizing the possible effects of microbubbles along the propagation path. Distribution of the bubbles formed from the droplets during the treatment is the major factor shaping the therapeutic region. A numerical model was proposed to simulate the bubble area evolution during this treatment. Using a linear acoustic equation to describe the ultrasound field, a threshold range was defined that determines the amount of bubbles vaporized in the treated area...
September 1, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/28635524/serology-and-protein-electrophoresis-for-evidence-of-exposure-to-12-mink-pathogens-in-free-ranging-american-mink-neovison-vison-in-argentina
#11
Pablo Eduardo Martino, Luis Ernesto Samartino, Néstor Oscar Stanchi, Nilda Esther Radman, Eduardo Joaquín Parrado
BACKGROUND: Basic pathologic characteristics for farmed minks were previously reported worldwide. However, its status in the wild has not been studied in detail. OBJECTIVE: Serology and electrophoresis were carried out for evidence of exposure to 12 mink pathogens on two different locations. ANIMALS AND METHODS: Serology was done in 87 wild minks by reference techniques against Toxoplasma gondii, Encephalitozoon cuniculi, Neospora caninum, Brucella abortus, Mycobacterium bovis, Leptospira interrogans, canine distemper virus (CDV), canine adenovirus (CAV), canine parvovirus (CPV), rabies virus (RV), Influenza A virus (FLUAV) and Aleutian disease virus (ADV)...
December 2017: Veterinary Quarterly
https://www.readbyqxmd.com/read/28630670/universal-structure-motifs-in-biominerals-a-lesson-from-nature-for-the-efficient-design-of-bioinspired-functional-materials
#12
REVIEW
Joe Harris, Corinna F Böhm, Stephan E Wolf
Biominerals are typically indispensable structures for their host organism in which they serve varying functions, such as mechanical support and protection, mineral storage, detoxification site, or as a sensor or optical guide. In this perspective article, we highlight the occurrence of both structural diversity and uniformity within these biogenic ceramics. For the first time, we demonstrate that the universality-diversity paradigm, which was initially introduced for proteins by Buehler et al. (Cranford & Buehler 2012 Biomateriomics; Cranford et al...
August 6, 2017: Interface Focus
https://www.readbyqxmd.com/read/28629280/absent-ductus-venosus-case-series-from-two-tertiary-centres
#13
Giuseppe Maria Maruotti, Gabriele Saccone, M D Andrea Ciardulli, Laura Letizia Mazzarelli, Vincenzo Berghella, M D Pasquale Martinelli
INTRODUCTION: Congenital absence of the ductus venosus (ADV) is a rare vascular anomaly often associated with fetal cardiac and extracardiac anomalies, aneuploidies, and hydrops. The prognosis depends on the patterns of abnormal venous circulation, on the associated malformations and on chromosomal aberrations. METHODS: We performed a retrospective audit of all consecutive cases with ADV referred in our centres and analysed the outcomes. RESULTS: A total of six cases with prenatally diagnosed ADV were identified...
June 19, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28607582/letter-to-the-editor-re-ahn-dh-krishna-k-blazer-m-et-al-a-modified-regimen-of-biweekly-gemcitabine-and-nab-paclitaxel-in-patients-with-metastatic-pancreatic-cancer-is-both-tolerable-and-effective-a-retrospective-analysis-ther-adv-med-oncol-https-doi-org-10
#14
https://www.readbyqxmd.com/read/28605812/transforming-growth-factor-%C3%AE-1-induced-nadph-oxidase-4-expression-and-fibrotic-response-in-conjunctival-fibroblasts
#15
Karl David Brown, Manisha H Shah, Guei-Sheung Liu, Elsa C Chan, Jonathan G Crowston, Hitesh M Peshavariya
Purpose: Fibrotic scarring after ocular surgeries and chemical burn injuries can impede clarity of the cornea and cause vision impairment. Transforming growth factor β (TGFβ) signaling pathway is known to mediate fibrotic scarring, and NADPH oxidase-derived reactive oxygen species has been shown to be an effector molecule that facilitates TGFβ1-mediated responses. The present study explores the expression profile and functional importance of NADPH oxidase (Nox) in conjunctival fibroblasts...
June 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28601677/impact-of-stem-cell-graft-on-early-viral-infections-and-immune-reconstitution-after-allogeneic-transplantation-in-adults
#16
Marina Illiaquer, Berthe-Marie Imbert-Marcille, Thierry Guillaume, Lucie Planche, Marie Rimbert, Céline Bressollette-Bodin, Amandine Le Bourgeois, Pierre Peterlin, Alice Garnier, Claire Le Houerou, Philippe Moreau, Mohamad Mohty, Patrice Chevallier
BACKGROUND: Viral infections are well-known complications after allogeneic stem cell transplant (allo-SCT). OBJECTIVES: We compared prospectively incidences of DNAemia and active infections (AI) for five opportunistic viruses (Human Herpesvirus 6 (HHV-6), Epstein-Barr virus (EBV), BK polyomavirus (BKPyV), Cytomegalovirus (CMV) and Adenovirus (ADV)) and kinetics of immune reconstitution (IR) in adults receiving either double umbilical cord blood (dUCB group) or unrelated peripheral blood stem cell (uPBSC group) allo-SCT after a reduced-intensity conditioning (RIC) regimen...
May 31, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28574580/echographic-features-and-perinatal-outcomes-in-fetuses-with-congenital-absence-of-ductus-venosus
#17
Raquel Garcia-Delgado, Raquel Garcia-Rodriguez, Azahar Romero Requejo, Marta Armas Roca, Luciana Obreros Zegarra, Margarita Medina Castellano, Jose A Garcia Hernandez
The purpose of this study was to describe the echographic features and perinatal outcomes of fetuses with absence of ductus venosus (ADV) MATERIAL AND METHODS: Retrospective review of 10 cases with ADV diagnosed by prenatal ultrasonography between January 2014 and February 2016 at a single referral center. Prenatal findings, umbilical shunting type, perinatal outcomes, and autopsy reports were reviewed RESULTS: A total of 11 491 fetuses underwent a first and second trimester screening during the study period...
June 2, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28574020/development-of-polymerase-chain-reaction-based-diagnostic-tests-for-detection-of-malsoor-virus-adenovirus-isolated-from-rousettus-species-of-bats-in-maharashtra-india
#18
Anita M Shete, Pragya Yadav, Vimal Kumar, Tushar Nikam, Kurosh Mehershahi, Prasad Kokate, Deepak Patil, Devendra T Mourya
BACKGROUND & OBJECTIVES: Bats are recognized as important reservoirs for emerging infectious disease and some unknown viral diseases. Two novel viruses, Malsoor virus (family Bunyaviridae, genus, Phlebovirus) and a novel adenovirus (AdV) (family, Adenoviridae genus, Mastadenovirus), were identified from Rousettus bats in the Maharashtra State of India. This study was done to develop and optimize real time reverse transcription - polymerase chain reaction (RT-PCR) assays for Malsoor virus and real time and nested PCR for adenovirus from Rousettus bats...
January 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28569786/brg1-mediated-nrf2-ho-1-pathway-activation-alleviates-hepatic-ischemia-reperfusion-injury
#19
Mian Ge, Weifeng Yao, Dongdong Yuan, Shaoli Zhou, Xi Chen, Yihan Zhang, Haobo Li, Zhengyuan Xia, Ziqing Hei
Cytoprotective gene heme oxygenase 1 (HO-1) could be induced by nuclear factor E2-related factor 2 (Nrf2) nuclear translocation. The purpose of this study was to determine the role of Brahma-related gene 1 (Brg1), a catalytic subunit of SWI2/SNF2-like chromatin remodeling complexes, in Nrf2/HO-1 pathway activation during hepatic ischemia-reperfusion (HIR). Our results showed that hepatic Brg1 was inhibited during early HIR while Brg1 overexpression reduced oxidative injury in CMV-Brg1 mice subjected to HIR...
June 1, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28555609/erratum
#20
(no author information available yet)
The editorial by Arun K. Gadre entitled "The Problem of Gift and Honorary Authorship - Who is an Author?" (J Int Adv Otol 2016; 12), Obtituaries by David A. Moffat entitled "In Memoriam: Per Moller"(J Int Adv Otol 2016; 12: 222) and by Angel Ramos Macias entitled "In Memoriam: John Niparko" (J Int Adv Otol 2016; 12: 223) were published without a DOI due to a technical error. These papers were since provided with the DOIs listed below; • Arun K. Gadre. The Problem of Gift and Honorary Authorship - Who is an Author? DOI: 10...
April 2017: Journal of International Advanced Otology
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