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Chao-Wei Hsu, Wei-Wen Su, Chuan-Mo Lee, Cheng-Yuan Peng, Wan-Long Chuang, Jia-Horng Kao, Heng-Cheng Chu, Yi-Hsiang Huang, Rong-Nan Chien, Yun-Fan Liaw
BACKGROUND: Efficacy of sequential therapy with nucleos(t)ide analogues and interferons versus monotherapy in patients with hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (CHB) remains unexplored. We aimed to assess efficacy and safety of sequential therapy with adefovir (ADV) or entecavir (ETV) followed by peginterferon (PEG-IFN) alfa-2a in Taiwanese patients with HBeAg-positive. METHODS: This randomized, placebo-controlled, double-blind trial was conducted at nine sites in Taiwan from April 2010 to October 2013...
February 15, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
Angelica Perna, Antonio De Luca, Laura Adelfi, Tammaro Pasquale, Bruno Varriale, Teresa Esposito
BACKGROUND: The thyroid gland is one of the largest endocrine glands in the body. The vast majority of TCs (> 90%) originate from follicular cells and are defined as differentiated thyroid cancers (DTC) and the two histological subtypes are the papillary TC with its variants and the follicular TC. Curcumin possesses a wide variety of biological functions, and thanks to its properties, it has gained considerable attention due to its profound medicinal values (Prasad, Gupta, Tyagi, and Aggarwal, Biotechnol Adv 32:1053-1064, 2014)...
February 15, 2018: BMC Complementary and Alternative Medicine
Ruidong Zhu, Danhui Weng, Shichun Lu, Dongdong Lin, Menglong Wang, Dongdong Chen, Jun Lv, Hongjun Li, Fudong Lv, Ling Xi, Jianfeng Zhou, Ding Ma, Ning Li
The present clinical trial assessed the effect of double-dose administration of replication-deficient adenovirus-thymidine kinase and ganciclovir (ADV-TK/GCV) in patients with advanced hepatocellular carcinoma (HCC) who underwent liver transplantation (LT). Eighty-six patients with single tumor diameters >5 cm or multiple tumors with diameters >3 cm each, regardless of vascular invasion, were examined over a follow-up period of 61 months. All patients underwent orthotopic LT; 43 received LT only, and 43 received LT plus double-dose ADV-TK/GCV gene therapy (LT + ADV-TK/GCV)...
February 2018: Human Gene Therapy
Adam Jaros, Zahra Badri, Pankaj Lochan Bora, Esmaeil Farajpour Bonab, Radek Marek, Michal Straka, Cina Foroutan-Nejad
A recent study (Sci. Adv. 2017, 3, e1602833) has shown that FH…OH2 hydrogen bond in a HF·H2O pair substantially shortens and the H-F bond elongates upon encapsulation of the cluster in C70 fullerene. This has been attributed to compression of the HF·H2O pair inside the cavity of C70. Here we present theoretical evidence that the effect is not caused by a mere compression of the H2O·HF pair but it is related to a strong lone-pair-π (LP-π) bonding with the fullerene cage. To support this argument, a systematic electronic structure study of selected small molecules (HF, H2O, and NH3) and their pairs enclosed in fullerene cages (C60, C70, and C90) has been performed...
February 12, 2018: Chemistry: a European Journal
Viviane Girardi, Meriane Demoliner, Caroline Rigotto, Vania Elisabete Schneider, Suelen Paesi, Fernando Rosado Spilki
Adenoviruses (AdV) are related to respiratory and gastrointestinal diseases in animals and human beings. Their wide genetic diversity in water bodies and their resistance to environmental conditions allow the use of AdV as a reliable marker for detection of fecal contamination. In this work, the diversity of AdV along Belo Stream - in the city of Caxias do Sul, Rio Grande do Sul, Brazil - was evaluated. Samples were compared in both concentrated and unconcentrated forms. The identification of different AdV species was performed by amplifying a partial sequence of the DNA polymerase gene...
February 2018: Journal of Water and Health
LeiLei Zhu, HongYun Zhao, ZhiYi Zhou, YongHong Xia, Zhigang Wang, Haitao Ran, Pan Li, JianLi Ren
In this study, we successfully developed a novel tumor homing-penetrating peptide - functionalized drug-loaded phase-transformation nanoparticles (tLyP-1-10-HCPT-PFP NPs) combining LIFU for tumor ultrasound molecular imaging and precise therapy. With the nanoscale particle size, tLyP-1-10-HCPT-PFP NPs could pass through the tumor vascular endothelial cell gap. Induced by tLyP-1 peptide with targeting and penetrating efficiency, tLyP-1-10-HCPT-PFP NPs could increase tumor accumulation and penetrate deeply into the extravascular tumor tissue, which penetrating through extracellular matrix, cellular membrane to cytoplasm even into cell nucleus...
February 8, 2018: Nano Letters
François Charrier, Sophie Rossi, Ferran Jori, Oscar Maestrini, Céline Richomme, François Casabianca, Christian Ducrot, Johan Jouve, Nicole Pavio, Marie-Frédérique Le Potier
Wildlife species as reservoirs of infectious pathogens represent a serious constraint in the implementation of disease management strategies. In the Mediterranean island of Corsica, the dynamics of hepatitis E virus (HEV) and Aujeszky's disease virus (ADV) are suspected to be influenced by interactions between wild and domestic pigs. To improve our understanding of these influences, we first compared the seroprevalences of both viruses in domestic pig populations from different locations with contrasted levels of wild-domestic interactions, ADV vaccination, biosafety, and farm husbandry...
2018: Frontiers in Veterinary Science
Volker Strenger, Gerald Merth, Herwig Lackner, Stephan W Aberle, Harald H Kessler, Markus G Seidel, Wolfgang Schwinger, Daniela Sperl, Petra Sovinz, Anna Karastaneva, Martin Benesch, Christian Urban
Haemophagocytic lymphohistiocytosis (HLH) is a possibly life-threatening syndrome of immune dysregulation and can be divided into primary (hereditary) and secondary forms (including malignancy-associated HLH (M-HLH)). We retrospectively analysed epidemiological, clinical, virological and laboratory data from patients with M-HLH treated at our department between 1995 and 2014. Out of 1.706 haemato-/oncologic patients treated at our department between 1995 and 2014, we identified 22 (1.29%) patients with secondary HLH (1...
February 6, 2018: Annals of Hematology
Liliana A González, Yaneisi Vázquez, Jorge E Mora, Christian E Palavecino, Pablo Bertrand, Marcela Ferrés, Ana M Contreras, Andrea A Beckhaus, Claudia A Riedel, Susan M Bueno
Human Respiratory Syncytial Virus (hRSV), human Metapneumovirus (hMPV) and Adenovirus (ADV), are three of the most prevalent viruses responsible for pneumonia and bronchiolitis in children and elderly worldwide, accounting for a high number of hospitalizations annually. Diagnosis of these viruses is required to take clinical actions that allow an appropriate patient management. Thereby, new strategies to design fast diagnostic methods are highly required. In the present work, six monoclonal antibodies (mAbs, two for each virus) specific for conserved proteins from hRSV, hMPV and ADV were generated and evaluated through different immunological techniques, based on detection of purified protein, viral particles and human samples...
January 31, 2018: Journal of Virological Methods
Jee Hyuk Kim, Heung Yong Jin, Hong Sun Baek, Kyung Ae Lee
No abstract text is available yet for this article.
January 2018: Chonnam Medical Journal
Thomas Lacour, Matthieu Guédra, Tony Valier-Brasier, François Coulouvrat
Nanodroplets have great, promising medical applications such as contrast imaging, embolotherapy, or targeted drug delivery. Their functions can be mechanically activated by means of focused ultrasound inducing a phase change of the inner liquid known as the acoustic droplet vaporization (ADV) process. In this context, a four-phases (vapor + liquid + shell + surrounding environment) model of ADV is proposed. Attention is especially devoted to the mechanical properties of the encapsulating shell, incorporating the well-known strain-softening behavior of Mooney-Rivlin material adapted to very large deformations of soft, nearly incompressible materials...
January 2018: Journal of the Acoustical Society of America
Xuechao Li, Juansheng Li, Lei Meng, Wanqi Zhu, Xinfeng Liu, Mei Yang, Deshan Yu, Lixia Niu, Xiping Shen
Understanding etiological role and epidemiological profile is needed to improve clinical management and prevention of acute respiratory infections (ARIs). A five-year prospective study about active surveillance for outpatients and inpatients with ARIs was conducted in Gansu province, China, from January 2011 to November 2015. Respiratory specimens were collected from patients and tested for eight respiratory viruses using polymerase chain reaction (PCR) or reverse transcription polymerase chain reaction (RT-PCR)...
February 1, 2018: Journal of Medical Virology
Massimiliano Bergallo, Ilaria Galliano, Paola Montanari, Marco Rassu, Valentina Daprà, Chiara Merlino, Pier-Angelo Tovo
BACKGROUND: MXPyV, like MWPyV, was identified in stool samples from children suffering diarrhea in Mexico. In this study, we used a home-made real time PCR to investigate the presence of this novel viruses in stool specimen collected from under-Five- Year-Old Children with gastroenteritis. METHODS: A total of 192 fecal specimens previously screened for RV, ADV, NoV, HPeV and SaV, were tested for MWPyV with Taqman real time PCR. RESULTS: The most commonly detected virus was NoV GII (33...
January 29, 2018: Minerva Pediatrica
Tong Jing, Kuang Ya-Shu, Wang Xue-Jun, Hou Han-Jing, Lai Yan, Yao Yi-An, Chen Fei, Liu Xue-Bo
Background: Endothelial microparticles (EMPs) are small vesicles released by endothelial cells (ECs); they are considered biomarkers for endothelial dysfunction and therapeutic targets in diabetes-related vascular disease. Sirtuins have also been shown to play important roles in diabetes by regulating endothelial dysfunction. However, the effect of sirtuin-incorporated EMPs on their parental ECs remains unknown. Aim: The present study aims to investigate the diagnostic value of EMPs in diabetes and detect the protective effects of sirtuin 6 (Sirt6) mRNA -incorporated EMPs on endothelial dysfunction...
December 26, 2017: Oncotarget
Laszlo S Toth, Werner Skrotzki, Yajun Zhao, Aurimas Pukenas, Christian Braun, Rainer Birringer
Employing a recent modeling scheme for grain boundary sliding [Zhao et al. Adv. Eng. Mater.2017, doi:10.1002/adem.201700212], crystallographic textures were simulated for nanocrystalline fcc metals deformed in shear compression. It is shown that, as grain boundary sliding increases, the texture strength decreases while the signature of the texture type remains the same. Grain boundary sliding affects the texture components differently with respect to intensity and angular position. A comparison of a simulation and an experiment on a Pd-10 atom % Au alloy with a 15 nm grain size reveals that, at room temperature, the predominant deformation mode is grain boundary sliding contributing to strain by about 60%...
January 25, 2018: Materials
Michael Spartalis, Eleni Tzatzaki, Diamantis I Tsilimigras, Eleftherios Spartalis
No abstract text is available yet for this article.
January 25, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
M Vallejo Ruiz, E Soria Saldise, C Mansilla Puerta, A Zabalza San Martín, N Ramírez
Epstein-Barr (EBV) and Adenovirus (AdV) viral infections represent a significant cause of morbi-mortality in allogeneic hematopoietic stem cell transplantation recipients due to the use of immunomyelosuppressive treatments and the prolonged period of immunodeficiency that they generate. To date, the post-transplant protective role of EBV and AdV specific CD8+ T lymphocytes (CTLs) has been demonstrated. However, other factors are increasingly important in regulating the reconstitution and activity of CTLs specific to these viruses such as different cell subpopulations (CD4 + T lymphocytes, regulatory T lymphocytes, dendritic cells, Natural Killer cells, etc...
January 23, 2018: Anales del Sistema Sanitario de Navarra
Igor Kissin
The different stages of the life cycle of a drug - 'prenatal' stage, birth of a drug, rapid growth, maturity and stability, decline, and status before 'death' - are reflected in the three following databases: journal articles (; patents (US Patent Office-; and approved drugs (FDA - These databases are huge, from authoritative sources, correctly classified, and they properly link different datasets...
January 18, 2018: Trends in Pharmacological Sciences
Anja K Faulhaber, Anke Dittmer, Felix Blind, Maximilian A Wächter, Silja Timm, Leon R Sütfeld, Achim Stephan, Gordon Pipa, Peter König
Ethical thought experiments such as the trolley dilemma have been investigated extensively in the past, showing that humans act in utilitarian ways, trying to cause as little overall damage as possible. These trolley dilemmas have gained renewed attention over the past few years, especially due to the necessity of implementing moral decisions in autonomous driving vehicles (ADVs). We conducted a set of experiments in which participants experienced modified trolley dilemmas as drivers in virtual reality environments...
January 22, 2018: Science and Engineering Ethics
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