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https://www.readbyqxmd.com/read/28448571/localization-of-adenovirus-morphogenesis-players-together-with-visualization-of-assembly-intermediates-and-failed-products-favor-a-model-where-assembly-and-packaging-occur-concurrently-at-the-periphery-of-the-replication-center
#1
Gabriela N Condezo, Carmen San Martín
Adenovirus (AdV) morphogenesis is a complex process, many aspects of which remain unclear. In particular, it is not settled where in the nucleus assembly and packaging occur, and whether these processes occur in a sequential or a concerted manner. Here we use immunofluorescence and immunoelectron microscopy (immunoEM) to trace packaging factors and structural proteins at late times post infection by either wildtype virus or a delayed packaging mutant. We show that representatives of all assembly factors are present in the previously recognized peripheral replicative zone, which therefore is the AdV assembly factory...
April 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28438249/the-acceptance-of-dating-violence-scale-adv-psychometric-properties-of-the-spanish-version
#2
Liria Fernández-González, Esther Calvete, Izaskun Orue
BACKGROUND: The main aim of this study was to analyse the psychometric properties of the Spanish version of the Acceptance of Dating Violence (ADV) scale, which assesses attitudes that justify the use of aggression in adolescents’ dating relationships. METHOD: A total of 1,579 high school students (49% girls) from Bizkaia (Spain), aged between 14 and 18 years (M = 15.79, SD = 1.16), completed this questionnaire along with the Irrational Beliefs Scale for Adolescents and the Conflict in Adolescent Dating Relationships Inventory...
May 2017: Psicothema
https://www.readbyqxmd.com/read/28436380/tenofovir-disoproxil-fumarate-monotherapy-is-superior-to-entecavir-adefovir-combination-therapy-in-patients-with-suboptimal-response-to-lamivudine-adefovir-therapy-for-nucleoside-resistant-hbv-a-96-week-prospective-multicenter-trial
#3
Sae Hwan Lee, Gab Jin Cheon, Hong Soo Kim, Sang Gyune Kim, Young Seok Kim, Soung Won Jeong, Jae Young Jang, Boo Sung Kim, Baek Gyu Jun, Young Don Kim, Dae Won Jun, Joo Hyun Sohn, Tae Yeob Kim, Byung Seok Lee
BACKGROUND: A complete virologic response is closely related to the long-term outcome of patients with chronic hepatitis B and prevention of emerging hepatitis B virus (HBV) mutations. We aimed to evaluate the efficacy of tenofovir disoproxil fumarate (TDF) monotherapy compared to entecavir-adefovir dipivoxil (ETV-ADV) combination therapy in patients with suboptimal responses to long-term lamivudine-adefovir dipivoxil (LAM-ADV) therapy for nucleoside analogue-resistant chronic hepatitis B...
April 24, 2017: Antiviral Therapy
https://www.readbyqxmd.com/read/28435892/dramatic-improvement-of-crispr-cas9-editing-in-candida-albicans-by-increased-single-guide-rna-expression
#4
Henry Ng, Neta Dean
The clustered regularly interspaced short palindromic repeat system with CRISPR-associated protein 9 nuclease (CRISPR/Cas9) has emerged as a versatile tool for genome editing in Candida albicans. Mounting evidence from other model systems suggests that the intracellular levels of single guide RNA (sgRNA) limit the efficiency of Cas9-dependent DNA cleavage. Here, we tested this idea and describe a new means of sgRNA delivery that improves previously described methods by ~10-fold. The efficiency of Cas9/sgRNA-dependent cleavage and repair of a single-copy yeast enhanced monomeric red fluorescent protein (RFP) gene was measured as a function of various parameters that are hypothesized to affect sgRNA accumulation, including transcriptional and posttranscriptional processing...
March 2017: MSphere
https://www.readbyqxmd.com/read/28409328/long-term-treatment-with-bosutinib-in-a-phase-1-2-study-in-japanese-chronic-myeloid-leukemia-patients-resistant-intolerant-to-prior-tyrosine-kinase-inhibitor-treatment
#5
Naoto Takahashi, Chiaki Nakaseko, Yukio Kobayashi, Koichi Miyamura, Chiho Ono, Yuichiro Koide, Yosuke Fujii, Kazunori Ohnishi
This long-term follow-up of a completed phase 1/2 study assessed the safety and efficacy of bosutinib in Japanese Philadelphia chromosome-positive, chronic phase (CP) or advanced phase (ADV) chronic myeloid leukemia patients who were resistant/refractory or intolerant to prior tyrosine kinase inhibitor treatment. This analysis included 63 patients with a median bosutinib follow-up of 132 weeks (range 3‒372). In the CP second-line (2L) cohort, the cumulative major cytogenetic response (MCyR) and major molecular response (MMR) rates throughout the study were 73 and 53%, respectively...
April 13, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/28407271/a-potent-hbsag-response-in-subjects-with-inactive-hbsag-carrier-treated-with-pegylated-interferon-alpha
#6
Zhenhuan Cao, Yali Liu, Lina Ma, Junfeng Lu, Yi Jin, Shan Ren, Zhimin He, Chengli Shen, Xinyue Chen
BACKGROUND: HBsAg clearance represents a clinical cure although the clearance rate is extremely low. The aim of this study was to evaluate the feasibility and safety profiles of pegylated-interferon α-2a (PEG-IFNα-2a) as a therapeutic option for inactive HBsAg carriers (IHCs). METHODS: 144 IHCs were enrolled and divided into a therapeutic group (102 subjects) and control group (42 subjects). PEG-IFNα-2a and PEG-IFNα-2a combined with Adefovir Dipivoxil (ADV) were used for treatment group subjects with hepatitis B virus (HBV) DNA <20 IU/mL and 20 IU/mL≤HBV DNA<2000 IU/mL, respectively...
April 13, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28403093/jejunojejunal-intussusception-after-roux-en-y-gastric-bypass-in-a-situs-inversus-totalis-patient-a-case-report
#7
Guangyi Jiang, Baojuan Fu, Sheng Lv, Junjie Hong, Xiujun Cai
INTRODUCTION: Situs inversus totalis (SIT) is an uncommon clinical manifestation. Patients with SIT typically have malformation in the thorax and abdomen. The incidence of SIT ranges from 1/10,000 to 1/20,000 (Al-Jumaily and Hoche. J Laparoendosc Adv Surg Tech A 2001;11:229). Jejunojejunal intussusception is a rare complication after Roux-en-Y gastric bypass. Intussusception in adult cases accounts for 5% of adult intestinal obstruction cases, while in children, the occurrence is high and the majority of them are idiopathic cases...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28397817/tenofovir-and-adefovir-down-regulate-mitochondrial-chaperone-trap1-and-succinate-dehydrogenase-subunit-b-to-metabolically-reprogram-glucose-metabolism-and-induce-nephrotoxicity
#8
Xinbin Zhao, Kun Sun, Zhou Lan, Wenxin Song, Lili Cheng, Wenna Chi, Jing Chen, Yi Huo, Lina Xu, Xiaohui Liu, Haiteng Deng, Julie A Siegenthaler, Ligong Chen
Despite the therapeutic success of tenofovir (TFV) for treatment of HIV-1 infection, numerous cases of nephrotoxicity have been reported. Mitochondrial toxicity has been purported as the major target of TFV-associated renal tubulopathy but the underlying molecular mechanism remains unclear. In this report, we use metabolomics and proteomics with HK-2 cells and animal models to dissect the molecular pathways underlying nephropathy caused by TFV and its more toxic analog, adefovir (ADV). Proteomic analysis shows that mitochondrial chaperone TRAP1 and mtDNA replicating protein SSBP1 were significantly down-regulated in TFV and ADV treated HK-2 cells compared with controls...
April 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28397477/real-time-pcr-detection-of-the-most-common-bacteria-and-viruses-causing-meningitis
#9
Oya Akkaya, Hulya Iren Guvenc, Serife Yuksekkaya, Aysegul Opus, Asuman Guzelant, Meral Kaya, Muhammet Guzel Kurtoglu, Nurettin Kaya
BACKGROUND: Central nervous system (CNS) infections require prompt diagnosis, as the clinical condition progresses rapidly and may lead to severe permanent sequelae or death. The causative agents include viruses, bacteria, fungi, and parasites. In this study, samples with the diagnosis of CNS infection based on cerebrospinal fluid (CSF) sent to us from other hospitals/labs, were studied by multiplex real-time Polymerase Chain Reaction (PCR) method. The purpose of this study is to demonstrate, retrospectively, the most common bacteria and viruses causing meningitis and seasonal distribution of these agents using the multiplex real-time PCR method in CSF samples...
April 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28393313/molecular-detection-of-viruses-in-kenyan-bats-and-discovery-of-novel-astroviruses-caliciviruses-and-rotaviruses
#10
Cecilia Waruhiu, Sheila Ommeh, Vincent Obanda, Bernard Agwanda, Francis Gakuya, Xing-Yi Ge, Xing-Lou Yang, Li-Jun Wu, Ali Zohaib, Ben Hu, Zheng-Li Shi
This is the first country-wide surveillance of bat-borne viruses in Kenya spanning from 2012-2015 covering sites perceived to have medium to high level bat-human interaction. The objective of this surveillance study was to apply a non-invasive approach using fresh feces to detect viruses circulating within the diverse species of Kenyan bats. We screened for both DNA and RNA viruses; specifically, astroviruses (AstVs), adenoviruses (ADVs), caliciviruses (CalVs), coronaviruses (CoVs), flaviviruses, filoviruses, paramyxoviruses (PMVs), polyomaviruses (PYVs) and rotaviruses...
April 6, 2017: Virologica Sinica
https://www.readbyqxmd.com/read/28392330/viral-reactivations-and-associated-outcomes-in-context-of-immune-reconstitution-after-pediatric-hematopoietic-cell-transplantation
#11
Rick Admiraal, Coco de Koning, Caroline A Lindemans, Marc B Bierings, Annemarie M J Wensing, A Birgitta Versluys, Tom F W Wolfs, Stefan Nierkens, Jaap Jan Boelens
BACKGROUND: Viral reactivations (VR) following hematopoietic cell transplantation (HCT) contribute to significant morbidity and mortality. Timely immune reconstitution (IR) is suggested to prevent VR. OBJECTIVES: We studied the relation between IR (as a continuous over-time-predictor) and VR (as time-varying-predictor), and the relation between VR and other clinical outcomes. METHODS: In this retrospective analysis, all patients receiving a first HCT between January-2004 and September-2014 were included...
April 6, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28373908/surveillance-for-respiratory-infectious-diseases-caused-by-6-common-viruses-in-a-recruit-training-site-in-the-northern-region-of-china
#12
Wei-Wei Chen, Wen Xu, Yang-Xin Xie, Yun-Hui Zhang, Dan Wu, Fu-Sheng Wang, Min Zhao
BACKGROUND: Recruit training sites are places with a high incidence of respiratory infectious diseases. Effective surveillance for acute respiratory infectious diseases in a recruit training site is an important way to prevent disease outbreaks. METHODS: Eight hundred recruits (722 males and 78 females) enlisted in autumn 2015 received a background survey within 24 h of settlement at the recruit training site, including their general personal information, vaccination history, mental status and clinical symptoms...
2017: Military Medical Research
https://www.readbyqxmd.com/read/28362809/antigen-capsid-display-on-human-adenovirus-35-via-pix-fusion-is-a-potent-vaccine-platform
#13
Nadine C Salisch, Marija Vujadinovic, Esmeralda van der Helm, Dirk Spek, Lars Vorthoren, Jan Serroyen, Harmjan Kuipers, Hanneke Schuitemaker, Roland Zahn, Jerome Custers, Jort Vellinga
Durable protection against complex pathogens is likely to require immunity that comprises both humoral and cellular responses. While heterologous prime-boost regimens based on recombinant, replication-incompetent Adenoviral vectors (AdV) and adjuvanted protein have been able to induce high levels of concomitant humoral and cellular responses, complex manufacturing and handling in the field may limit their success. To combine the benefits of genetic and protein-based vaccination within one vaccine construct and to facilitate their use, we generated Human Adenovirus 35 (HAdV35) vectors genetically encoding a model antigen based on the Plasmodium falciparum (P...
2017: PloS One
https://www.readbyqxmd.com/read/28356525/microrna-mir-27-inhibits-adenovirus-infection-by-suppressing-the-expression-of-snap25-and-txn2
#14
M Machitani, F Sakurai, K Wakabayashi, K Nakatani, M Tachibana, H Mizuguchi
Recent studies have reported that host microRNAs (miRNAs) regulate infection with several types of viruses via various mechanisms, and that inhibition of the miRNA processing factors enhances or prevents viral infection. However, it has not been clarified whether these effects of miRNAs extend to adenovirus (Ad) infection. Here we show that miR-27a/b efficiently inhibit infection with an Ad via the down-regulation of SNAP25 and TXN2, which are members of the SNARE proteins and the thioredoxin family, respectively...
March 29, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28351603/predictors-of-hbeag-seroconversion-after-long-term-nucleos-t-ide-analogues-treatment-for-chronic-hepatitis-b-a-multicenter-study-in-real-clinical-setting
#15
Weiyan Yu, Yadong Wang, Chuan Shen, Ru Ji, Li Zhang, Xin Zhao, Miao Su, Yin Zhang, Wenyan He, Jianguo Cao, Yanshuang Hao, Shengpeng Chen, Caiyan Zhao
AIMS: To evaluate the HBeAg seroconversion rate in real clinical setting and explore its predictors in long-term nucleos(t)ide analogues (NAs) treatment for chronic hepatitis B (CHB). METHODS: 251 patients were recruited from January 2001 to September 2009 in four hospitals in HeBei province, China, for this retrospective study. Clinical and laboratory data before and after treatment with lamivudine (LAM, 100mg daily), adefovir (ADV, 10mg daily), telbivudine (LDT, 600mg daily), ETV (0...
March 25, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28334052/identifying-fallers-among-ophthalmic-patients-using-classification-tree-methodology
#16
Paolo Melillo, Ada Orrico, Franco Chirico, Leandro Pecchia, Settimio Rossi, Francesco Testa, Francesca Simonelli
PURPOSE: To develop and validate a tool aiming to support ophthalmologists in identifying, during routine ophthalmologic visits, patients at higher risk of falling in the following year. METHODS: A group of 141 subjects (age: 73.2 ± 11.4 years), recruited at our Eye Clinic, underwent a baseline ophthalmic examination and a standardized questionnaire, including lifestyles, general health, social engagement and eyesight problems. Moreover, visual disability was assessed by the Activity of Daily Vision Scale (ADVS)...
2017: PloS One
https://www.readbyqxmd.com/read/28314429/erratum-to-heavy-metals-in-iberian-soils-removal-by-current-adsorbents-amendments-and-prospective-for-aerogels-adv-colloid-interf-sci-237-2016-28-42
#17
João P Vareda, Artur J M Valente, Luisa Durães
No abstract text is available yet for this article.
November 2016: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28302206/-relationship-between-viral-load-of-human-bocavirus-and-clinical-characteristics-in-children-with-acute-lower-respiratory-tract-infection
#18
Xiao-Fang Ding, Bing Zhang, Li-Li Zhong, Le-Yun Xie, Ni-Guang Xiao
OBJECTIVE: To investigate the prevalence of human bocavirus (HBoV) in children with acute lower respiratory tract infection and to explore the relationship between the viral load of HBoV and the clinical characteristics of acute lower respiratory tract infection in children. METHODS: A total of 1 554 nasopharyngeal aspirates from children who were hospitalized due to acute lower respiratory tract infection between March 2011 and March 2014 were collected. Quantitative real-time PCR was used to detect 12 RNA and 2 DNA viruses, adenovirus (ADV) and HBoV, and to measure the viral load of HBoV in HBoV-positive children...
March 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28299601/the-presence-of-norovirus-and-adenovirus-on-environmental-surfaces-in-relation-to-the-hygienic-level-in-food-service-operations-associated-with-a-suspected-gastroenteritis-outbreak
#19
Leena Maunula, M Rönnqvist, R Åberg, J Lunden, M Nevas
Norovirus (NoV) gastroenteritis outbreaks appear frequently in food service operations (FSOs), such as in restaurants and canteens. In this study the presence of NoV and adenovirus (AdV) genomes was investigated on the surfaces of premises, especially in kitchens, of 30 FSOs where foodborne gastroenteritis outbreaks were suspected. The objective was to establish a possible association between the presence of virus genomes on surfaces and a visual hygienic status of the FSOs. NoV genome was found in 11 and AdV genome in 8 out of 30 FSOs...
March 15, 2017: Food and Environmental Virology
https://www.readbyqxmd.com/read/28298283/erratum-for-schwingshackl-et-al-perspective-nutrigrade-a-scoring-system-to-assess-and-judge-the-meta-evidence-of-randomized-controlled-trials-and-cohort-studies-in-nutrition-research-adv-nutr-2016-7-994-1004
#20
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