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https://www.readbyqxmd.com/read/29777402/a-national-study-of-the-use-of-asymptomatic-systemic-imaging-for-surveillance-following-breast-cancer-treatment-aft-01
#1
Jessica R Schumacher, Heather B Neuman, George J Chang, Benjamin D Kozower, Stephen B Edge, Menggang Yu, David J Vanness, Yajuan Si, Elizabeth A Jacobs, Amanda B Francescatti, Patricia A Spears, Jeffrey Havlena, Taiwo Adesoye, Daniel McKellar, David Winchester, Elizabeth S Burnside, Caprice C Greenberg
BACKGROUND: Although not guideline recommended, studies suggest 50% of locoregional breast cancer patients undergo systemic imaging during follow-up, prompting its inclusion as a Choosing Wisely measure of potential overuse. Most studies rely on administrative data that cannot delineate scan intent (prompted by signs/symptoms vs. asymptomatic surveillance). This is a critical gap as intent is the only way to distinguish overuse from appropriate care. OBJECTIVE: Our aim was to assess surveillance systemic imaging post-breast cancer treatment in a national sample accounting for scan intent...
May 17, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29725191/sistas-inspiring-sistas-through-activity-and-support-sistas-study-design-and-demographics-of-participants
#2
Malcolm Bevel, Oluwole A Babatunde, Sue P Heiney, Heather M Brandt, Michael D Wirth, Thomas G Hurley, Samira Khan, Hiluv Johnson, Cassandra M Wineglass, Tatiana Y Warren, E Angela Murphy, Erica Sercy, Amanda S Thomas, James R Hébert, Swann Arp Adams
Introduction: Recruiting racial, ethnic, and other underserved minorities into conventional clinic-based and other trials is known to be challenging. The Sistas Inspiring Sistas Through Activity and Support (SISTAS) Program was a one-year randomized controlled trial (RCT) to promote physical activity and healthy eating among AA women in SC to reduce inflammatory biomarkers, which are linked to increased breast cancer (BrCa) risk and mortality. This study describes the development, recruitment, and implementation of the SISTAS clinical trial and provides baseline characteristics of the study participants...
2018: Ethnicity & Disease
https://www.readbyqxmd.com/read/29668832/changes-in-physical-activity-behavior-and-c-reactive-protein-in-breast-cancer-patients
#3
Catherine M Sabiston, Carsten Wrosch, Andrée L Castonguay, Benjamin D Sylvester
Background: C-reactive protein (CRP) concentrations are associated with morbidity and mortality in breast cancer patients and moderate-vigorous physical activity (MVPA) may help regulate CRP levels. Purpose: The purpose of this prospective study was to examine intraindividual and interindividual changes in MVPA on changes in CRP levels among early posttreatment breast cancer patients. Methods: During five data collections over the first year posttreatment for breast cancer, women (N = 138, Mage = 55...
April 12, 2018: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/29614476/social-relationships-inflammation-markers-and-breast-cancer-incidence-in-the-women-s-health-initiative
#4
Evan L Busch, Eric A Whitsel, Candyce H Kroenke, Yang C Yang
OBJECTIVES: Previous research has reported associations between social relationships and carcinogenesis. Inflammation is a potential mediator of these associations. To clarify these links for one tumor site, we examined associations between social relationships, circulating inflammation markers, and breast cancer incidence. MATERIALS AND METHODS: Among 132,262 participants from the prospective Women's Health Initiative, we used linear and logistic regression to evaluate associations between social relationship characteristics (social support, social strain, social network size) and inflammation markers of C-reactive protein (CRP) and white blood cell count (WBC)...
March 31, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29599081/improvement-of-early-detection-of-breast-cancer-through-collaborative-multi-country-efforts-medical-physics-component
#5
Patricia Mora, Keith Faulkner, Ahmed M Mahmoud, Vesna Gershan, Aruna Kausik, Urban Zdesar, María-Ester Brandan, Serap Kurt, Jasna Davidović, Dina H Salama, Erkin Aribal, Clara Odio, Arvind K Chaturvedi, Zahida Sabih, Saša Vujnović, Diana Paez, Harry Delis
PURPOSE: The International Atomic Energy Agency (IAEA) through a Coordinated Research Project on "Enhancing Capacity for Early Detection and Diagnosis of Breast Cancer through Imaging", brought together a group of mammography radiologists, medical physicists and radiographers; to investigate current practices and improve procedures for the early detection of breast cancer by strengthening both the clinical and medical physics components. This paper addresses the medical physics component...
March 26, 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29553851/adjuvant-radiotherapy-does-not-affect-hemostasis
#6
Katrine Munk Begtrup, Johanne Andersen Hojbjerg, Birgitte Vrou Offersen, Anne-Mette Hvas
Cancer is associated with increased risk of venous thromboembolic disease. Venous thromboembolic disease accounts for a substantial addition to morbidity and mortality rates in cancer patients and is the second leading cause of death in cancer patients, exceeded only by the underlying cancer. Only few previous studies have investigated the influence of radiotherapy on hemostasis and whether radiotherapy in itself causes an increased risk of venous thromboembolic disease. The aim was to investigate if adjuvant radiotherapy affects hemostasis after surgery and chemotherapy in patients with breast cancer...
March 19, 2018: Platelets
https://www.readbyqxmd.com/read/29528450/sterilized-talc-pleurodesis-for-malignant-pleural-effusions-a-phase-ii-study-for-investigational-new-drug-application-in-japan
#7
Hideo Saka, Masahide Oki, Chiyoe Kitagawa, Yoshihito Kogure, Yuki Kojima, Akiko M Saito, Atsuko Ishida, Teruomi Miyazawa, Koji Takeda, Kazuhiko Nakagawa, Shinji Sasada, Shunichi Negoro
Background: Malignant pleural effusion is a commonly seen complication of malignancies such as lung and breast cancers. In Western countries, talc is frequently used as a standard therapeutic agent (pleurodesis agent) with the aim of alleviating symptoms including dyspnea and chest pain. Talc is not recognized as a pleurodesis agent in Japan. The aim of this study was to verify the efficacy and safety of sterilized talc (NPC-05) for the introduction of talc in Japan. Methods: The study was a single-arm, open-label, investigator-initiated trial conducted jointly at six institutions...
March 8, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29488212/associations-of-metabolic-syndrome-and-c-reactive-protein-with-mortality-from-total-cancer-obesity-linked-cancers-and-breast-cancer-among-women-in-nhanes-iii
#8
Wambui G Gathirua-Mwangi, Yiqing Song, Patrick O Monahan, Victoria L Champion, Terrell W Zollinger
Although metabolic syndrome (MetS) is a prognostic factor for cancer occurrence, the association of MetS and cancer mortality remains unclear. The purpose of this study was to evaluate whether MetS, components of MetS and C-reactive protein (CRP) are associated with cancer mortality in women. A total of 400 cancer deaths, with 140 deaths from obesity-linked-cancers (OLCas), [breast (BCa), colorectal, pancreatic and endometrial], linked through the National Death Index, were identified from 10,104 eligible subjects aged ≥18 years...
February 27, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29450753/use-of-breast-imaging-after-treatment-for-locoregional-breast-cancer-aft-01
#9
Taiwo Adesoye, Jessica R Schumacher, Heather B Neuman, Stephen Edge, Daniel McKellar, David P Winchester, Amanda B Francescatti, Caprice C Greenberg
BACKGROUND: Annual mammography is recommended after breast cancer treatment. However, studies suggest its under-utilization for Medicare patients. Utilization in the broader population is unknown, as is the role of breast magnetic resonance imaging (MRI). Understanding factors associated with imaging use is critical to improvement of adherence to recommendations. METHODS: A random sample of 9835 eligible patients receiving surgery for stages 2 and 3 breast cancer from 2006 to 2007 was selected from the National Cancer Database for primary data collection...
June 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29439678/correlation-between-global-methylation-level-of-peripheral-blood-leukocytes-and-serum-c-reactive-protein-level-modified-by-mthfr-polymorphism-a-cross-sectional-study
#10
Masanori Nojima, Motoki Iwasaki, Yoshio Kasuga, Shiro Yokoyama, Hiroshi Onuma, Hideki Nishimura, Ritsu Kusama, Teruhiko Yoshida, Shoichiro Tsugane
BACKGROUND: Chronic inflammatory conditions are associated with higher tumor incidence through epigenetic and genetic alterations. Here, we focused on an association between an inflammation marker, C-reactive-protein (CRP), and global DNA methylation levels of peripheral blood leukocytes. METHODS: The subjects were 384 healthy Japanese women enrolled as the control group of a case-control study for breast cancer conducted from 2001 to 2005. Global DNA methylation was quantified by Luminometric Methylation Assay (LUMA)...
February 13, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29394767/-a-case-of-rapidly-advancing-g-csf-producing-pleomorphic-carcinoma-of-the-breast-appearing-as-an-inflammatory-breast-cancer
#11
Ayumi Ogawa, Goushi Oda, Takashi Yasukawa, Yuuichi Kumaki, Noriaki Takiguchi, Keiko Suzuki, Kouichi Mori, Tsuyosi Nakagawa
We report a rare case of pleomorphic carcinoma of the breast, suspected of being a granulocyte-colony stimulating factor (G-CSF)producing tumor, in a 75-year-old woman. She presented with a red and swollen breast, 3 weeks after undergoing core needle biopsy(CNB). Her leukocyte counts and C-reactive protein(CRP)levels were markedly high. At first, she was suspected to have an abscess and was initiated on a course of antibiotics. However, her condition rapidly deteriorated; therefore, she underwent an emergency mastectomy...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29238750/biomarkers-of-aging-associated-with-past-treatments-in-breast-cancer-survivors
#12
Zorica Scuric, Judith E Carroll, Julienne E Bower, Sam Ramos-Perlberg, Laura Petersen, Stephanie Esquivel, Matt Hogan, Aaron M Chapman, Michael R Irwin, Elizabeth C Breen, Patricia A Ganz, Robert Schiestl
Radiation and chemotherapy are effective treatments for cancer, but are also toxic to healthy cells. Little is known about whether prior exposure to these treatments is related to markers of cellular aging years later in breast cancer survivors. We examined whether past exposure to chemotherapy and/or radiation treatment was associated with DNA damage, telomerase activity, and telomere length 3-6 years after completion of primary treatments in breast cancer survivors (stage 0-IIIA breast cancer at diagnosis)...
2017: NPJ Breast Cancer
https://www.readbyqxmd.com/read/29178353/the-risk-of-febrile-neutropenia-in-breast-cancer-patients-following-adjuvant-chemotherapy-is-predicted-by-the-time-course-of-interleukin-6-and-c-reactive-protein-by-modelling
#13
Ida Netterberg, Mats O Karlsson, Elisabet I Nielsen, Angelica L Quartino, Henrik Lindman, Lena E Friberg
AIMS: Early identification of patients with febrile neutropenia (FN) is desirable for initiation of preventive treatment, such as with antibiotics. In this study, the time courses of two inflammation biomarkers, interleukin (IL)-6 and C-reactive protein (CRP), following adjuvant chemotherapy of breast cancer, were characterized. The potential to predict development of FN by IL-6 and CRP, and other model-derived and clinical variables, was explored. METHODS: The IL-6 and CRP time courses in cycles 1 and 4 of breast cancer treatment were described by turnover models where the probability for an elevated production following initiation of chemotherapy was estimated...
March 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29141853/the-effects-of-resistance-exercise-on-biomarkers-of-breast-cancer-prognosis-a-pooled-analysis-of-three-randomized-trials
#14
Kerri M Winters-Stone, Lisa J Wood, Sydnee Stoyles, Nathan F Dieckmann
Background: Using a secondary data analysis from randomized controlled trials comparing one year of resistance exercise ( n = 109) to a placebo control condition ( n = 106) in postmenopausal, posttreatment breast cancer survivors, we investigated the influence of resistance training and changes in body composition on markers associated with cancer progression. Methods: Measures included serum levels of insulin, IGF-1, IGFBP1-3, leptin, serum amyloid A (SAA), adiponectin, C-reactive protein (CRP), IL1β, TNFα, IL6, and IL8, and body composition (total, lean and fat mass in kg) by DXA at baseline, 6, and 12 months...
February 2018: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29136770/magnesium-valproate-ameliorates-type-1-diabetes-and-cardiomyopathy-in-diabetic-rats-through-estrogen-receptors
#15
Samir Rabadiya, Shradhha Bhadada, Ashvin Dudhrejiya, Devendra Vaishnav, Bhoomika Patel
Estrogen is known to exhibit cardioprotective and antihyperlipidemic action. Valproic acid has been shown to upregulate estrogen receptors (ERs) in breast and prostate cancer tissues. No pharmacological evaluations for magnesium valproate (MgV) so far have been done for diabetic cadio-lipidemic complications. Based on the above context, current study was undertaken to evaluate the therapeutic effectiveness of MgV in cardiac complications associated with type-1 diabetes mellitus in rats wherein diabetes was induced by single tail vein injection of streptozotocin (STZ, 45mg/kg, IV) in female Sprague Dawley rats and treatment of MgV (210mg/kg, PO) was given for eight weeks to diabetic animals, after which, various biochemical and cardiac biomarkers, hypertrophic, hemodynamic and histological parameters along with immunohistochemistry of ERs in the left ventricle (LV) were estimated...
January 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29095653/curcuma-longa-turmeric-for-prevention-of-capecitabine-induced-hand-foot-syndrome-a-pilot-study
#16
Vanessa Armenio Scontre, Janine Capobiango Martins, Claudia Vaz de Melo Sette, Haila Mutti, Daniel Cubero, Fernando Fonseca, Auro Del Giglio
Hand-foot syndrome (HFS) is common and frequently occurs in the first cycle of treatment in approximately 40% to 50% of patients who receive capecitabine. Turmeric (Curcuma longa) is a plant used in Ayurvedic medicine with clinical activity in various inflammatory conditions. Our objective was to evaluate whether turmeric was active for the prevention of capecitabine-induced HFS. We included patients older than 18 years of age without previous exposure to capecitabine who were scheduled to receive this medication...
November 2, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29066694/-clinical-evaluation-of-indoleamine-2-3-dioxygenase-in-the-serum-of-patients-with-locally-advanced-breast-cancer-during-mohs-paste-treatment
#17
Hitomi Kubota, Kenichi Sakurai, Shigeru Fujisaki, Yukiko Hara, Shuhei Suzuki, Keita Adachi, Ryouichi Tomita, Katsuhisa Enomoto, Tomohiro Hirano, Reina Saga, Makoto Makishima
Locally advanced breast cancer lesions often compromise patients' quality of life(QOL). Mohs paste is a histopathological fixative with zinc chloride as the main ingredient. It is applied when performing chemosurgery for skin tumors. In recent years, this paste has reportedly been very effective for the control of various symptoms of skin metastases in inoperable advanced cancers, such as pungent odor and hemorrhage, in the field of palliative care. We evaluated the clinical significance of indoleamine 2, 3-dioxygenase(IDO)in the serum of patients with locally advanced breast cancer during Mohs paste treatment...
October 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28983080/biomarkers-of-inflammation-and-breast-cancer-risk-a-case-control-study-nested-in-the-epic-varese-cohort
#18
Claudia Agnoli, Sara Grioni, Valeria Pala, Alessandra Allione, Giuseppe Matullo, Cornelia Di Gaetano, Giovanna Tagliabue, Sabina Sieri, Vittorio Krogh
Breast cancer (BC) is the leading cause of cancer death in women. Adipokines, and other inflammation molecules linked to adiposity, are suspected to be involved in breast carcinogenesis, however prospective findings are inconclusive. In a prospective nested case-control study within the EPIC-Varese cohort, we used conditional logistic regression to estimate rate ratios (RRs) for BC, with 95% confidence intervals (CI), in relation to plasma levels of C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), interleukin-6, leptin, and adiponectin, controlling for BC risk factors...
October 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28869444/plasma-tum2-pk-correlates-with-tumor-size-crp-and-ca-15-3-in-metastatic-breast-carcinomas-short-versus-long-term-follow-up-study-of-the-egyptian-breast-cancer-patients
#19
Eman El-Abd, Marwa El-Sheikh, Sameh Zaky, Wagdy Fayed, Safinaz El-Zoghby
BACKGROUND: The key regulator of tumor metabolome is the glycolytic isoenzyme M2-PK which favors the generation of nucleic acid via glutaminolysis as hypoxic adaptive mechanism in the tumor cells. AIM: The study aimed to evaluate the prognostic role of M2-PK, CRP, and CA 15-3 in preoperative and metastatic breast carcinomas. PATIENTS AND METHODS: The study included 70 females; 15 controls, 33 preoperative primary breast carcinomas clinically metastasis free, and 22 clinically diagnosed metastatic breast carcinomas...
August 23, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28851415/association-of-pre-chemotherapy-peripheral-blood-pro-inflammatory-and-coagulation-factors-with-reduced-relative-dose-intensity-in-women-with-breast-cancer
#20
Yuan Yuan, Nilesh Vora, Can-Lan Sun, Daneng Li, Enrique Soto-Perez-de-Celis, Joanne Mortimer, The-Hang Luu, George Somlo, James Waisman, David Smith, Joseph Chao, Vani Katheria, Timothy Synold, Vivi Tran, Shu Mi, Abrahm Levi, Anait Arsenyan, Jennifer Choi, Laura Zavala, Susan Yost, Arti Hurria
BACKGROUND: Chemotherapy decreases the risk of relapse and mortality in early-stage breast cancer (BC), but it comes with the risk of toxicity. Chemotherapy efficacy depends on relative dose intensity (RDI), and an RDI < 85% is associated with worse overall survival. The pro-inflammatory (interleukin (IL)-6, C-reactive protein (CRP)) and coagulation factors (D-dimer) serve as biomarkers of aging. The purpose of this study is to determine if these biomarkers are associated with reduced RDI in women with stage I-III BC...
August 29, 2017: Breast Cancer Research: BCR
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