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https://www.readbyqxmd.com/read/28869444/plasma-tum2-pk-correlates-with-tumor-size-crp-and-ca-15-3-in-metastatic-breast-carcinomas-short-versus-long-term-follow-up-study-of-the-egyptian-breast-cancer-patients
#1
Eman El-Abd, Marwa El-Sheikh, Sameh Zaky, Wagdy Fayed, Safinaz El-Zoghby
BACKGROUND: The key regulator of tumor metabolome is the glycolytic isoenzyme M2-PK which favors the generation of nucleic acid via glutaminolysis as hypoxic adaptive mechanism in the tumor cells. AIM: The study aimed to evaluate the prognostic role of M2-PK, CRP, and CA 15-3 in preoperative and metastatic breast carcinomas. PATIENTS AND METHODS: The study included 70 females; 15 controls, 33 preoperative primary breast carcinomas clinically metastasis free, and 22 clinically diagnosed metastatic breast carcinomas...
August 23, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28851415/association-of-pre-chemotherapy-peripheral-blood-pro-inflammatory-and-coagulation-factors-with-reduced-relative-dose-intensity-in-women-with-breast-cancer
#2
Yuan Yuan, Nilesh Vora, Can-Lan Sun, Daneng Li, Enrique Soto-Perez-de-Celis, Joanne Mortimer, The-Hang Luu, George Somlo, James Waisman, David Smith, Joseph Chao, Vani Katheria, Timothy Synold, Vivi Tran, Shu Mi, Abrahm Levi, Anait Arsenyan, Jennifer Choi, Laura Zavala, Susan Yost, Arti Hurria
BACKGROUND: Chemotherapy decreases the risk of relapse and mortality in early-stage breast cancer (BC), but it comes with the risk of toxicity. Chemotherapy efficacy depends on relative dose intensity (RDI), and an RDI < 85% is associated with worse overall survival. The pro-inflammatory (interleukin (IL)-6, C-reactive protein (CRP)) and coagulation factors (D-dimer) serve as biomarkers of aging. The purpose of this study is to determine if these biomarkers are associated with reduced RDI in women with stage I-III BC...
August 29, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28846716/association-between-local-inflammation-and-breast-tissue-age-related-lobular-involution-among-premenopausal-and-postmenopausal-breast-cancer-patients
#3
Mirette Hanna, Isabelle Dumas, Michèle Orain, Simon Jacob, Bernard Têtu, François Sanschagrin, Alexandre Bureau, Brigitte Poirier, Caroline Diorio
Increased levels of pro-inflammatory markers and decreased levels of anti-inflammatory markers in the breast tissue can result in local inflammation. We aimed to investigate whether local inflammation in the breast tissue is associated with age-related lobular involution, a process inversely related to breast cancer risk. Levels of eleven pro- and anti-inflammatory markers were assessed by immunohistochemistry in normal breast tissue obtained from 164 pre- and postmenopausal breast cancer patients. Involution status of the breast (degree of lobular involution and the predominant lobule type) was microscopically assessed in normal breast tissue on hematoxylin-eosin stained mastectomy slides...
2017: PloS One
https://www.readbyqxmd.com/read/28846105/c-reactive-protein-binds-to-integrin-%C3%AE-2-and-fc%C3%AE-receptor-i-leading-to-breast-cell-adhesion-and-breast-cancer-progression
#4
E-S Kim, S Y Kim, M Koh, H-M Lee, K Kim, J Jung, H S Kim, W K Moon, S Hwang, A Moon
C-reactive protein (CRP) is an acute phase protein synthesized upon the inflammatory responses, associated with breast cancer. The process of tumor cell invasion and metastasis involves the adherence of cells to the extracellular matrix via integrin as a receptor for matrix molecules. The present study investigated the role of CRP in the adhesive phenotype of breast cells and the underlying mechanisms. Here, we first showed that CRP induces adhesion of MCF10A human breast epithelial cells through the activation of integrin α2 signaling...
August 28, 2017: Oncogene
https://www.readbyqxmd.com/read/28730765/prognostic-role-of-inflammatory-biomarkers-in-metastatic-breast-cancer
#5
Ibrahim Petekkaya, Ozan Unlu, Emir C Roach, Gizem Gecmez, Alexis K Okoh, Taner Babacan, Furkan Sarici, Ozge Keskin, Cagatay Arslan, Emine Petekkaya, Ali R Sever, Kadri Altundag
PURPOSE: The effects of inflammation on the prognosis, life expectancy and several parameters such as response to treatment of breast cancer have been previously studied. The purpose of this study was to investigate the effect of inflammatory markers on prognosis in patients with metastatic breast cancer. METHODS: This study was conducted on 81 patients with metastatic breast cancer who have been followed up at the Department of Medical Oncology, Hacettepe University Institute of Oncology, between December, 2009 and March, 2014...
May 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28709031/bisphenol-a-induces-cox-2-through-the-mitogen-activated-protein-kinase-pathway-and-is-associated-with-levels-of-inflammation-related-markers-in-elderly-populations
#6
Heewon Song, Joonwoo Park, Phuong T C Bui, KeunOh Choi, Myung Chan Gye, Yun-Chul Hong, Jin Hee Kim, Young Joo Lee
Bisphenol A (BPA) is a well-known endocrine-disrupting chemical, and it is one of the highest volume chemicals produced worldwide. Even though several in vivo and in vitro studies showed positive associations of BPA exposure with pro-inflammatory cytokines such as tumor necrosis factor-α and interleukin (IL)-6, the mechanism by which BPA induces inflammation is unclear. We investigated the mechanism by which BPA induces inflammation (expression of inflammation-related genes, changes in oxidative stress, and cell proliferation and migration) and evaluated the effect of BPA exposure on inflammation-related markers in epidemiologic studies using repeat urine and serum samples from elderly subjects...
October 2017: Environmental Research
https://www.readbyqxmd.com/read/28702218/effects-of-a-parallel-arm-randomized-controlled-weight-loss-pilot-study-on-biological-and-psychosocial-parameters-of-overweight-and-obese-breast-cancer-survivors
#7
Andrea Y Arikawa, Beth C Kaufman, Susan K Raatz, Mindy S Kurzer
BACKGROUND: Weight gain often occurs after breast cancer (BC) diagnosis and obesity along with sedentary behavior are associated with increased risk of BC recurrence and mortality. The primary objective of this study was to determine whether a significant weight loss, of approximately 10%, would lead to beneficial changes in biomarkers associated with cancer and/or cancer recurrence, and quality of life (QOL) in overweight and obese BC survivors. METHODS: This parallel-arm study took place in Minneapolis, Minnesota, from January 2009 until March 2010...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/28682735/sedentary-behaviors-and-biomarkers-among-breast-cancer-survivors
#8
Sheri J Hartman, Catherine R Marinac, Lisa Cadmus-Bertram, Jacqueline Kerr, Loki Natarajan, Suneeta Godbole, Ruth E Patterson, Brittany Morey, Dorothy D Sears
BACKGROUND: Sedentary behavior is associated with increased risk of poor outcomes in breast cancer survivors, but underlying mechanisms are not well understood. This pilot study explored associations between different aspects of sedentary behaviors (sitting, prolonged sitting, sit-to-stand transitions, and standing) and breast cancer risk-related biomarkers in breast cancer survivors (n = 30). METHODS: Sedentary behavior variables were objectively measured with thigh-worn activPALs...
September 14, 2017: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/28657165/serum-n-glycome-alterations-in-breast-cancer-during-multi-modal-treatment-and-follow-up
#9
Radka Saldova, Vilde D Haakensen, Einar Rødland, Ian Walsh, Henning Stöckmann, Olav Engebraaten, Anne-Lise Børresen-Dale, Pauline M Rudd
Using our recently developed high-throughput automated platform, N-glycans from all serum glycoproteins from breast cancer patients were analysed at diagnosis, after neoadjuvant chemotherapy, surgery, radiotherapy, and up to 3 years after surgery. Surprisingly, alterations in the serum N-glycome after chemotherapy were pro-inflammatory with an increase in glycan structures associated with cancer. Surgery, on the other hand, induced anti-inflammatory changes in the serum N-glycome, towards a non-cancerous phenotype...
June 28, 2017: Molecular Oncology
https://www.readbyqxmd.com/read/28640164/associations-between-postmenopausal-endogenous-sex-hormones-and-c-reactive-protein-a-clearer-picture-with-regional-adiposity-adjustment
#10
Shannon M Conroy, Heather K Neilson, Rachel O'Reilly, Christy G Woolcott, Frank Z Stanczyk, Kerry S Courneya, Christine M Friedenreich
OBJECTIVE: To better understand the pathogenesis of inflammatory-related diseases after menopause, we studied the adiposity-independent association between endogenous sex hormones and C-reactive protein (CRP), a biomarker of inflammation. METHODS: We conducted a secondary, cross-sectional analysis of baseline data from the Alberta Physical Activity and Breast Cancer Prevention Trial (2003-2007), including 319 healthy, postmenopausal women not using hormone therapy...
September 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28617135/influence-of-personalized-exercise-recommendations-during-rehabilitation-on-the-sustainability-of-objectively-measured-physical-activity-levels-fatigue-and-fatigue-related-biomarkers-in-patients-with-breast-cancer
#11
Philipp Zimmer, Freerk T Baumann, Max Oberste, Joachim Schmitt, Niklas Joisten, Philipp Hartig, Alexander Schenk, Rafaela Kuhn, Wilhelm Bloch, Monika Reuss-Borst
PURPOSE: Only one-third of patients with breast cancer reach the recommended activity level of 15 to 25 MET h/wk. The aim of this study was to determine the influence of personalized exercise recommendations during rehabilitation on patients' physical activity level, fatigue, and self-perceived cognitive function as well as on side effect-associated biomarkers. METHODS: Total metabolic rate, physical activity level, mean MET and steps, fatigue, self-perceived cognitive functioning , and biomarkers (C-reactive protein [CRP], interleukin 6, macrophage migration inhibiting factor [MIF], tumor necrosis factor [TNF]-α, brain-derived neurotrophic factor [BDNF], insulin-like growth factor 1 [IGF1]) were assessed in 60 patients with breast cancer in the aftercare phase before ( t0) and 8 months after ( t1) the intervention...
June 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/28559409/association-of-pre-chemotherapy-peripheral-blood-pro-inflammatory-and-coagulation-factors-with-physical-function-in-women-with-breast-cancer
#12
Yuan Yuan, Nilesh Vora, Can-Lan Sun, Daneng Li, David Smith, Joanne Mortimer, The-Hang Luu, George Somlo, James Waisman, Joseph Chao, Vani Katheria, Timothy Synold, Vivi Tran, Shu Mi, Tao Feng, Abrahm Levi, Anait Arsenyan, Jennifer Choi, Laura Zavala, Susan Yost, Arti Hurria
BACKGROUND: Pro-inflammatory and coagulation factors serve as biomarkers of aging and functional reserve. The purpose of this study was to determine if pro-inflammatory (interleukin-6 [IL-6], C-reactive protein [CRP]), and coagulation (D-dimer) factors were associated with pre-chemotherapy functional status in women with stage I-III breast cancer. PATIENTS AND METHODS: Prior to chemotherapy initiation in patients with stage I-III breast cancer, the following was captured: IL-6, CRP, D-dimer blood levels, and physical function measures including activities of daily living (ADL, subscale of Medical Outcomes Study Physical Health); instrumental activities of daily living (IADL, subscale of the Older Americans Resources and Services Program); Timed Up and Go (TUG); physician-rated Karnofsky Performance Status (KPS); and self-rated KPS...
May 30, 2017: Oncologist
https://www.readbyqxmd.com/read/28546059/inflammation-and-attentional-bias-in-breast-cancer-survivors
#13
Chloe C Boyle, Patricia A Ganz, Kathleen M Van Dyk, Julienne E Bower
Evidence suggests an association between inflammation and depression, although findings are mixed. Focusing on core processes in depression may clarify associated biological underpinnings. Negative cognitive bias is a key component of depression, but has not been examined in relation to inflammation. Thus, we tested the hypothesis that elevated inflammatory markers would be associated with negative attentional bias in a sample of 91 breast cancer survivors. Participants were drawn from a larger study and provided blood samples for assessment of peripheral markers of inflammation and completed questionnaires and neuropsychological testing...
May 22, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28489884/comparison-of-the-prognostic-values-of-preoperative-inflammation-based-parameters-in-patients-with-breast-cancer
#14
COMPARATIVE STUDY
Hideya Takeuchi, Hirohumi Kawanaka, Seiichi Fukuyama, Nobuhide Kubo, Shoji Hiroshige, Tokujiro Yano
Peripheral blood-derived inflammation-based markers, including C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR) are indicators of prognosis in various malignant tumors. The present study aimed to identify the inflammation-based parameters that are most suitable for predicting outcomes in patients with breast cancer. Two hundred ninety-six patients who underwent surgery for localized breast cancer were reviewed retrospectively...
2017: PloS One
https://www.readbyqxmd.com/read/28452680/contemporary-radiooncological-management-of-bone-metastases-from-breast-cancer-factors-associated-with-prescription-of-different-fractionation-regimens-short-or-long-course-in-a-rural-part-of-north-norway-with-long-travel-distance
#15
Carsten Nieder, Astrid Dalhaug, Ellinor Haukland, Bård Mannsåker, Adam Pawinski
The aim of this study was to reduce barriers that prevent implementation of evidence-based recommendations about single-fraction palliative radiotherapy (PRT) and to demonstrate that single-fraction PRT yields similar outcomes as long-course treatment (≥10 fractions) in patients with bone metastases from breast cancer. This retrospective study (2007-2014) included 118 Norwegian female patients. All patients received guideline-conform systemic therapy including bone-targeting agents. Median survival was 12...
2017: International Journal of Circumpolar Health
https://www.readbyqxmd.com/read/28342988/an-anti-inflammatory-dietary-intervention-to-reduce-breast-cancer-recurrence-risk-study-design-and-baseline-data
#16
Amelie G Ramirez, Dorothy Long Parma, Edgar Muñoz, Kristin D Mendoza, Crystel Harb, Alan E C Holden, Michael Wargovich
U.S. breast cancer survivors (BCSs) are expected to increase to 4 million in the next 5-10years. Cancer recurrence risk is highest among obese survivors. Inflammatory (Pro-I) biomarkers including C-reactive protein (CRP), Interleukins -3, -6, and -8 (IL-3, IL-6, IL-8), and Tumor Necrosis Factor (TNF)-α have been associated with cancer recurrence risk. Nutritional interventions aimed at reducing inflammation (INF) may contribute to reduced cancer recurrence risk, but studies have been limited to animal models...
June 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28292922/the-association-of-the-c-reactive-protein-inflammatory-biomarker-with-breast-cancer-incidence-and-mortality-in-the-women-s-health-initiative
#17
Sandahl H Nelson, Theodore M Brasky, Ruth E Patterson, Gail A Laughlin, Donna Kritz-Silverstein, Beatrice J Edwards, Dorothy Lane, Thomas E Rohan, Gloria Y F Ho, JoAnn E Manson, Andrea Z LaCroix
Purpose: To examine associations of prediagnosis high-sensitivity C-reactive protein (hsCRP) with breast cancer incidence and postdiagnosis survival and to assess whether associations are modified by body mass index (BMI).Methods: A prospective analysis of the Women's Health Initiative was conducted among 17,841 cancer-free postmenopausal women with baseline hsCRP measurements. Cox proportional hazards models were used to examine associations between hsCRP concentrations and (i) breast cancer risk (n cases = 1,114) and (ii) all-cause mortality after breast cancer diagnosis...
July 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28283917/risk-perception-and-psychological-distress-in-genetic-counselling-for-hereditary-breast-and-or-ovarian-cancer
#18
G Cicero, R De Luca, P Dorangricchia, G Lo Coco, C Guarnaccia, D Fanale, V Calò, A Russo
Oncological Genetic Counselling (CGO) allows the identification of a genetic component that increases the risk of developing a cancer. Individuals' psychological reactions are influenced by both the content of the received information and the subjective perception of their own risk of becoming ill or being a carrier of a genetic mutation. This study included 120 participants who underwent genetic counselling for breast and/or ovarian cancer. The aim of the study was to examine the relation between their cancer risk perception and the genetic risk during CGO before receiving genetic test results, considering the influence of some psychological variables, in particular distress, anxiety and depression...
March 10, 2017: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/28252552/effects-of-resistance-training-and-protein-supplementation-in-breast-cancer-survivors
#19
Takudzwa A Madzima, Michael J Ormsbee, Erica A Schleicher, Robert J Moffatt, Lynn B Panton
PURPOSE: This study aimed to evaluate 12 wk of resistance training (RT; n = 16) and protein supplementation (RT + protein; n = 17) on muscular strength, body composition, and blood biomarkers of muscle (insulin-like growth factor 1 [IGF-1]), fat (adiponectin), and inflammation (human C-reactive protein [CRP]) in breast cancer survivors (BCS). METHODS: Thirty-three BCS (59 ± 8 yr) were measured pre- and posttraining for one-repetition maximum (1-RM) muscular strength (chest press and leg extension), body composition (lean mass [LM] and fat mass [FM]) via dual-energy x-ray absorptiometry, and serum concentrations of IGF-1, adiponectin, and CRP...
July 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28193310/depressive-symptoms-and-inflammation-are-independent-risk-factors-of-fatigue-in-breast-cancer-survivors
#20
C Xiao, A H Miller, J Felger, D Mister, T Liu, M A Torres
BACKGROUND: Psychosocial and inflammatory factors have been associated with fatigue in breast cancer survivors. Nevertheless, the relative contribution and/or interaction of these factors with cancer-related fatigue have not been well documented. METHOD: This cross-sectional study enrolled 111 stage 0-III breast cancer patients treated with breast surgery followed by whole breast radiotherapy. Fatigue was measured by the total score of the Multidimensional Fatigue Inventory-20...
February 14, 2017: Psychological Medicine
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