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https://www.readbyqxmd.com/read/28772036/implantation-of-a-left-ventricular-assist-device-to-provide-long-term-support-for-end-stage-duchenne-muscular-dystrophy-associated-cardiomyopathy
#1
Douglas Stoller, Faris Araj, Alpesh Amin, Catherine Fitzsimmons, Robert Morlend, Jennifer T Thibodeau, Claudio Ramaciotti, Mark H Drazner, Dan M Meyer, Pradeep P A Mammen
A young man with Duchenne muscular dystrophy presented to the UT Southwestern Neuromuscular Cardiomyopathy Clinic with advanced heart failure. Despite maximal medical therapy, his cardiac function continued to decline requiring initiation of inotrope therapy. Given the patient's clinical deterioration, a left ventricular assist device (LVAD) was implanted as destination therapy after undergoing a multidisciplinary assessment. The patient tolerated the surgical implantation of the LVAD without any significant complications, and he has had a relatively unremarkable course 38 months post-LVAD implantation...
August 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/28706748/comparison-of-globus-pallidus-interna-and-subthalamic-nucleus-in-deep-brain-stimulation-for-parkinson-disease-an-institutional-experience-and-review
#2
REVIEW
Shazia Mirza, Umar Yazdani, Richard Dewey Iii, Neepa Patel, Richard B Dewey, Svjetlana Miocinovic, Shilpa Chitnis
Deep Brain Stimulation (DBS) has revolutionized the lives of patients of Parkinson disease, offering therapeutic options to those not benefiting entirely from medications alone. With its proven track record of outperforming the best medical management, the goal is to unlock the full potential of this therapy. Currently, the Globus Pallidus Interna (GPi) and Subthalamic Nucleus (STN) are both viable targets for DBS, and the choice of site should focus on the constellation of symptoms, both motor and nonmotor, which are key determinants to quality of life...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28576594/time-and-effort-required-for-tissue-acquisition-and-submission-in-lung-cancer-clinical-trials
#3
Sandra Garcia, Jessica M Saltarski, Jingsheng Yan, Xian-Jin Xie, David E Gerber
BACKGROUND: Increasingly, analysis of tumor tissue samples for predictive and pharmacodynamic biomarkers is incorporated into lung cancer clinical trials. We determined the time and effort required for tissue acquisition and submission. PATIENTS AND METHODS: We analyzed data from patients enrolled from 2009 to 2016 at UT Southwestern onto lung cancer trials with mandatory or optional submission of tumor tissue. We collected dates of treatment-related events and staff communications; nature of tissue requirement and biomarker analysis; and location of archival tissue...
May 8, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28328976/high-school-science-fair-and-research-integrity
#4
Frederick Grinnell, Simon Dalley, Karen Shepherd, Joan Reisch
Research misconduct has become an important matter of concern in the scientific community. The extent to which such behavior occurs early in science education has received little attention. In the current study, using the web-based data collection program REDCap, we obtained responses to an anonymous and voluntary survey about science fair from 65 high school students who recently competed in the Dallas Regional Science and Engineering Fair and from 237 STEM-track, post-high school students (undergraduates, 1st year medical students, and 1st year biomedical graduate students) doing research at UT Southwestern Medical Center...
2017: PloS One
https://www.readbyqxmd.com/read/28267687/hypertension-s-3-dilemmas-and-3-solutions-pharmacology-of-the-kidney-in-hypertension
#5
William A Pettinger
The Hypertension Community has 3 conflicting dilemmas: a goal systolic pressure of 120 mm Hg or less (the SPRINT Trials), 40% of our 60,000,000 hypertensives still sustain blood pressures above 140/90 mm Hg, and our most potent antihypertensive drug minoxidil sits on the sidelines, imprisoned in the Food and Drug Administration's Black Box designation. My solutions to these dilemmas are: (1) review of the facts of our most potent antihypertensive drug minoxidil which is essentially free of toxicity, (2) treatment focus on the fundamental cause of high blood pressure, that is excess dietary sodium and, (3) prevention of, and/or reversal of, the fundamental mechanism of worsening hypertension, arteriolar hypertrophy...
March 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/28048816/mo-de-207b-05-predicting-gene-mutations-in-renal-cell-carcinoma-based-on-ct-imaging-features-validation-using-tcga-tcia-datasets
#6
X Chen, Z Zhou, K Thomas, J Wang
PURPOSE: The goal of this work is to investigate the use of contrast enhanced computed tomographic (CT) features for the prediction of mutations of BAP1, PBRM1, and VHL genes in renal cell carcinoma (RCC). METHODS: For this study, we used two patient databases with renal cell carcinoma (RCC). The first one consisted of 33 patients from our institution (UT Southwestern Medical Center, UTSW). The second one consisted of 24 patients from the Cancer Imaging Archive (TCIA), where each patient is connected by a unique identi?er to the tissue samples from the Cancer Genome Atlas (TCGA)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27820787/enhancing-physician-assistant-student-clinical-rotation-evaluations-with-the-rime-scoring-format-a-retrospective-3-year-analysis
#7
David J Klocko
PURPOSE: This article describes a 3-year retrospective analysis of student clinical rotation evaluations using the Reporter-Interpreter-Manager-Educator (RIME) scoring format. The intent of the analysis was to assess scoring trends to determine whether students with high scores on the Physician Assistant National Certifying Exam (PANCE) also achieved high RIME scores on clinical rotations. METHODS: The top and bottom quartiles of PANCE scores were identified for the University of Texas (UT) Southwestern Medical Center's physician assistant (PA) classes of 2010-2012 (n = 106)...
November 3, 2016: Journal of Physician Assistant Education
https://www.readbyqxmd.com/read/27510747/studying-genetic-resilience-to-improve-human-health
#8
E T Cirulli, G S Ginsburg
No abstract text is available yet for this article.
September 2017: Oral Diseases
https://www.readbyqxmd.com/read/27429226/partial-orbicularis-resection-for-the-augmentation-of-traditional-internal-brow-pexy-the-tuck-and-rise
#9
Blair K Armstrong, Deepak Sobti, Ronald Mancini
PURPOSE: Brow ptosis commonly occurs with aging. Minimally invasive techniques are varied and include neurotoxin paralysis of eyebrow depressors and internal brow pexy. The authors present a modification of the traditional brow-pexy surgery which incorporates weakening of the lateral eyebrow depressor, the orbicularis oculi muscle, to synergistically influence brow position. METHODS: This retrospective review includes 44 brows in 22 patients treated over a 14-month period...
November 2016: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/26254481/development-of-the-parkland-ut-southwestern-colonoscopy-reporting-system-cors-for-evidence-based-colon-cancer-surveillance-recommendations
#10
Celette Sugg Skinner, Samir Gupta, Ethan A Halm, Shaun Wright, Katharine McCallister, Wendy Bishop, Noel Santini, Christian Mayorga, Deepak Agrawal, Brett Moran, Joanne M Sanders, Amit G Singal
OBJECTIVE: Through colonoscopy, polyps can be identified and removed to reduce colorectal cancer incidence and mortality. Appropriate use of surveillance colonoscopy, post polypectomy, is a focus of healthcare reform. MATERIALS AND METHODS: The authors developed and implemented the first electronic medical record-based colonoscopy reporting system (CoRS) that matches endoscopic findings with guideline-consistent surveillance recommendations and generates tailored results and recommendation letters for patients and providers...
March 2016: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/26129050/tu-g-brb-00-clinical-trials-in-proton-and-particle-therapy
#11
(no author information available yet)
UNLABELLED: Proton therapy, in particular, and ion therapy, just beginning, are becoming an increasing focus of attention in clinical radiation oncology and medical physics. Both modalities have been criticized of lacking convincing evidence from randomized trials proving their efficacy, justifying the higher costs involved in these therapies.This session will provide an overview of the current status of clinical trials in proton therapy, including recent developments in ion therapy. As alluded to in the introductory talk by Dr...
June 2015: Medical Physics
https://www.readbyqxmd.com/read/26129048/tu-g-brb-05-panel-discussion-clinical-trials-in-proton-and-ion-therapy-are-we-ready
#12
R Schulte
UNLABELLED: Proton therapy, in particular, and ion therapy, just beginning, are becoming an increasing focus of attention in clinical radiation oncology and medical physics. Both modalities have been criticized of lacking convincing evidence from randomized trials proving their efficacy, justifying the higher costs involved in these therapies.This session will provide an overview of the current status of clinical trials in proton therapy, including recent developments in ion therapy. As alluded to in the introductory talk by Dr...
June 2015: Medical Physics
https://www.readbyqxmd.com/read/26129047/tu-g-brb-02-clinical-trials-in-particle-therapy-open-questions
#13
H Choy
UNLABELLED: Proton therapy, in particular, and ion therapy, just beginning, are becoming an increasing focus of attention in clinical radiation oncology and medical physics. Both modalities have been criticized of lacking convincing evidence from randomized trials proving their efficacy, justifying the higher costs involved in these therapies.This session will provide an overview of the current status of clinical trials in proton therapy, including recent developments in ion therapy. As alluded to in the introductory talk by Dr...
June 2015: Medical Physics
https://www.readbyqxmd.com/read/26129046/tu-g-brb-01-topic-introduction-do-we-need-clinical-trials-in-particle-therapy-and-how-can-medical-physics-support-them
#14
R Schulte
UNLABELLED: Proton therapy, in particular, and ion therapy, just beginning, are becoming an increasing focus of attention in clinical radiation oncology and medical physics. Both modalities have been criticized of lacking convincing evidence from randomized trials proving their efficacy, justifying the higher costs involved in these therapies.This session will provide an overview of the current status of clinical trials in proton therapy, including recent developments in ion therapy. As alluded to in the introductory talk by Dr...
June 2015: Medical Physics
https://www.readbyqxmd.com/read/26129044/tu-g-brb-04-digital-phantoms-for-developing-protocols-in-particle-therapy
#15
C Lee
UNLABELLED: Proton therapy, in particular, and ion therapy, just beginning, are becoming an increasing focus of attention in clinical radiation oncology and medical physics. Both modalities have been criticized of lacking convincing evidence from randomized trials proving their efficacy, justifying the higher costs involved in these therapies.This session will provide an overview of the current status of clinical trials in proton therapy, including recent developments in ion therapy. As alluded to in the introductory talk by Dr...
June 2015: Medical Physics
https://www.readbyqxmd.com/read/26129043/tu-g-brb-03-iroc-houston-s-proton-beam-validation-for-clinical-trials
#16
P Taylor
UNLABELLED: Proton therapy, in particular, and ion therapy, just beginning, are becoming an increasing focus of attention in clinical radiation oncology and medical physics. Both modalities have been criticized of lacking convincing evidence from randomized trials proving their efficacy, justifying the higher costs involved in these therapies.This session will provide an overview of the current status of clinical trials in proton therapy, including recent developments in ion therapy. As alluded to in the introductory talk by Dr...
June 2015: Medical Physics
https://www.readbyqxmd.com/read/26036902/estrogens-obesity-inflammation-and-breast-cancer-what-is-the-link
#17
REVIEW
Kristy A Brown, Evan R Simpson
It gives me great pleasure to contribute to this special issue of Seminars which honors the career of Bruce Carr. As it happens, Bruce was my first Fellow upon my arrival at the Green Center for Reproductive Biology Sciences at UT Southwestern Medical Center in 1977. At that time, the Center was filled with luminaries of Reproductive Endocrinology, such as John Porter, Jack Johnston, Norman Gant, and of course the Director, Paul MacDonald, so to be given the responsibility of mentoring a new Fellow was a daunting responsibility...
May 2015: Seminars in Reproductive Medicine
https://www.readbyqxmd.com/read/25927107/retraction-notice-to-%C3%A2-methylation-of-apoptosis-related-genes-in-the-pathogenesis-and-prognosis-of-prostate-cancer%C3%A2-cancer-lett-242-2-2006-222%C3%A2-230-makoto-suzuki-hisayuki-shigematsu-narayan-shivapurkar-jyotsna-reddy-kuniharu-miyajima-takao-takahashi-adi-f-gazdar
#18
(no author information available yet)
Available online <2nd December 2008>. This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the first author, who accepts responsibility. Following an internal review at the UT Southwestern Medical Center in Dallas, evidence has been found of improper manipulation and duplication of Figure 1 in this article.
April 28, 2015: Cancer Letters
https://www.readbyqxmd.com/read/25834165/charitable-food-distribution-sites-offer-novel-opportunities-for-cancer-prevention-research-and-intervention-among-vulnerable-hard-to-reach-and-underserved-populations
#19
R T Higashi, Lee Sjc Craddock, T Leonard, E Cuate, S L Pruitt
People who live in food-insecure households face significant unmet health needs. At the same time, this population may be under-represented in clinical research studies because of the population's limited and intermittent engagement with the health care system. We describe preliminary results of a research partnership between UT Southwestern Medical Center (UTSW) and Crossroads Community Services (CCS), the largest charitable food distributor of the North Texas Food Bank. The goal of the study is to improve understanding of this population's health- and mammography-related needs, knowledge and service utilization...
April 2015: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/25623550/developing-a-comprehensive-resident-education-evaluation-system-in-the-era-of-milestone-assessment
#20
Aimee K Gardner, Daniel J Scott, Michael A Choti, John C Mansour
OBJECTIVES: In an effort to move training programs toward competency-based education, the Accreditation Council for Graduate Medical Education (ACGME) introduced the Next Accreditation System (NAS), which organizes specific milestones regarding resident skills, knowledge, and abilities along a continuum. In order to foster innovation and creativity, the ACGME has provided programs with minimal guidelines regarding the optimal way to approach these milestones. METHODS: The education team at UT Southwestern embraced the milestones and developed a process in which performance assessment methods were critically evaluated, mapped onto an extrapolated performance list corresponding to the areas required by the ACGME milestones, and filled gaps in the previous system by modifying evaluation tools and creating new program components...
July 2015: Journal of Surgical Education
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