Read by QxMD icon Read

Adaptive support ventilation

Alexandra Jochmans-Lemoine, Manju Shahare, Jorge Soliz, Vincent Joseph
We previously reported that rats and mice that have been raised for more than 30 generations in La Paz, Bolivia (3600m), display divergent physiological responses to high altitude (HA), including improved respiratory and metabolic control in mice. In the present study we asked whether these traits would also be present in response to hypoxia at sea level (SL). To answer this question, we exposed rats (SD) and mice (FVB) to normoxia (21% O2) or hypoxia (15 and 12% O2) for 6 hours and measured ventilation and metabolic rate (whole body plethysmography), and expression of the transcription factor HIF-1α (ELISA and Mass Spectrometry) and other proteins whose expression are regulated by hypoxia (Glucose Transporter 1, Pyruvate Dehydrogenase Kinase 1, and Angiopoietin 2 - Mass Spectrometry) in the brainstem...
October 14, 2016: Journal of Experimental Biology
Pnina Weiss, Meir Kryger
Positive airway pressure (PAP) is considered first-line therapy for moderate to severe obstructive sleep apnea and may also be considered for mild obstructive sleep apnea, particularly if it is symptomatic or there are concomitant cardiovascular disorders. Continuous PAP is most commonly used. Other modes, such as bilevel airway pressure, autotitrating positive airway pressure, average volume assured pressure support, and adaptive support ventilation, play important roles in the management of sleep-related breathing disorders...
October 6, 2016: Otolaryngologic Clinics of North America
Marc R Mendler, Claudia Weber, Mohammad A Hassan, Li Huang, Benjamin Mayer, Helmut D Hummler
BACKGROUND: There are few data available on the interaction of inflations, chest compressions (CC), and delivery of tidal volumes in newborn infants undergoing resuscitation in the presence of endotracheal tube (ET) leaks. OBJECTIVES: To determine the effects of different respiratory support strategies along with CC on changes in tidal volume and ET leaks in hypoxic newborn piglets with cardiac arrest. METHODS: Asphyxiated newborn piglets, intubated with weight-adapted uncuffed ET, were randomized into three groups and resuscitated according to ILCOR 2010 guidelines: (1) T-piece resuscitator (TPR) group = peak inspiratory pressure (PIP)/positive end-expiratory pressure (PEEP) 25/5 cm H2O, rate 30/min, inflations interposed between CC (3:1 ratio); (2) self- inflating bag (SIB) group = PIP 25 cm H2O without PEEP, rate 30/min, inflations interposed between CC (3:1 ratio), and (3) ventilator group = PIP/PEEP of 25/5 cm H2O, rate 30/min...
September 20, 2016: Neonatology
Andrew R Martin, Chris Jackson, Samuel Fromont, Chloe Pont, Ira M Katz, Georges Caillobotte
BACKGROUND: Inhaled nitric oxide (NO) is a selective pulmonary vasodilator used primarily in the critical care setting for patients concurrently supported by invasive or noninvasive positive pressure ventilation. NO delivery devices interface with ventilator breathing circuits to inject NO in proportion with the flow of air/oxygen through the circuit, in order to maintain a constant, target concentration of inhaled NO. METHODS: In the present article, a NO injection and mixing element is presented...
2016: Biomedical Engineering Online
Mirko Belliato, Antonella Degani, Antonino Buffa, Fabio Sciutti, Michele Pagani, Carlo Pellegrini, Giorgio Antonio Iotti
Monitoring veno-venous extracorporeal membrane oxygenation (vvECMO) during 76 days of continuous support in a 42-years old patient with end-stage pulmonary disease, listed for double-lung transplantation. Applying a new monitor (Landing(®), Eurosets, Medolla, Italy) and describing how measured and calculated parameters can be used to understand the variable interdependency between artificial membrane lung (ML) and patient native lung (NL). During vvECMO, in order to understand how the respiratory function is shared between ML and NL, ideally we should obtain data about oxygen transfer and CO2 removal, both by ML and NL...
August 24, 2016: Journal of Clinical Monitoring and Computing
Lillian Festvåg, Anne-Kristine Schanke, Nils Erik Gilhus, Sigurd Aarrestad, Kari Lofthus, Stein Johnsen, Geir Strømsholm, Steinar Øyhaugen, Ragnhild Skovly Hartviksen, Johan Kvalvik Stanghelle
OBJECTIVE: To explore the physical and social situation of the Norwegian polio population in 2014, and to compare the status of this population in 2014 with the results of a similar survey carried out 20 years previously, in 1994. DESIGN: The study was based on a questionnaire covering demographics, polio history, and current medical, psychological and social conditions. SUBJECTS: The questionnaire was prepared in cooperation with the National Society of Polio Survivors and others with known polio (n = 1,968)...
October 5, 2016: Journal of Rehabilitation Medicine
Cristina Dólera-Moreno, Antonio Palazón-Bru, Francisco Colomina-Climent, Vicente Francisco Gil-Guillén
BACKGROUND: The existing models to predict mortality in intensive care units (ICU) present difficulties in clinical practice. OBJECTIVES: The aim of this study was to develop and internally validate a points system to predict mortality in the ICU, which can be applied instantly and with high discriminating power. METHODS: This cohort study comprised all patients admitted to the ICU in a Spanish region between January 2013 and April 2014, followed from admission to death or discharge (N=1113)...
August 3, 2016: International Journal of Clinical Practice
Bernardo Selim, Kannan Ramar
INTRODUCTION: Volume assured pressure support (VAPS) and adaptive servo ventilation (ASV) are non-invasive positive airway pressure (PAP) modes with sophisticated negative feedback control systems (servomechanism), having the capability to self-adjust in real time its respiratory controlled variables to patient's respiratory fluctuations. However, the widespread use of VAPS and ASV is limited by scant clinical experience, high costs, and the incomplete understanding of propriety algorithmic differences in devices' response to patient's respiratory changes...
September 2016: Expert Review of Medical Devices
Xavier Navarro-Sune, Anna L Hudson, Fabrizio De Vico Fallani, Jaque Martinerie, Adrien Witon, Pierre Puget, Mathieu Raux, Thomas Similowski, Mario Chavez
During mechanical ventilation, patient-ventilator disharmony is frequently observed and may result in increased breathing effort, compromising the patient's comfort and recovery. This circumstance requires clinical intervention and becomes challenging when patients are sedated or verbal communication is difficult. In this work, we propose a brain computer interface (BCI) to automatically and non-invasively detect patient-ventilator disharmony from electroencephalographic (EEG) signals: a brain-ventilator interface...
July 19, 2016: IEEE Transactions on Bio-medical Engineering
Nehemiah T Liu, Michael G Salter, Muzna N Khan, Richard D Branson, Perenle Enkheebetaar, George C Kramer, José Salinas, Nicole Riberio Marques, Michael P Kinsky
: Pulmonary injury can be characterized by an increased need for FiO2 to maintain SaO2. We tested a smart oxygenation system (SOS) that utilizes the activity of a closed-loop control FiO2 algorithm (CLC-FiO2) to rapidly assess acute respiratory distress syndrome (ARDS) severity so that rescue ventilation (RscVent) can be initiated earlier. After baseline data, a pulse-oximeter (SpO2) was placed. Sheep were then subjected to burn and smoke inhalation injury and followed for 48 hr. Initially, sheep were spontaneously ventilating and then randomized to: standard of care (SOC) (n = 6), in which RscVent began when PaO2 <90 mmHg or FiO2 <0...
July 7, 2016: Shock
Teruhiko Imamura, Koichiro Kinugawa, Daisuke Nitta, Issei Komuro
Adaptive servo-ventilation support and Waon therapy are recently developed non-pharmacological and noninvasive therapies for patients with heart failure refractory to guideline-directed medical therapy. These therapies decrease both preload and afterload, increase cardiac output, and appear to ameliorate autonomic nerve activity. However, the time course of autonomic nerve activity during these therapies remains unclear. We performed heart rate variability analysis using the MemCalc power spectral density method (MemCalc system; Suwa Trust Co, Tokyo) to assess autonomic nerve activity during adaptive servo-ventilation support and Waon therapy in two different cases and determined the time course of autonomic nerve activity during these therapies...
July 27, 2016: International Heart Journal
Cristina Cigana, Francesca Bernardini, Marcella Facchini, Beatriz Alcalá-Franco, Camilla Riva, Ida De Fino, Alice Rossi, Serena Ranucci, Pauline Misson, Eric Chevalier, Maj Brodmann, Michel Schmitt, Achim Wach, Glenn E Dale, Daniel Obrecht, Alessandra Bragonzi
The clinical development of antibiotics with a new mode of action combined with efficient pulmonary drug delivery is a priority against untreatable Pseudomonas aeruginosa lung infections. POL7001 is a macrocycle antibiotic belonging to the novel class of protein epitope mimetic (PEM) molecules with selective and potent activity against P. aeruginosa We investigated ventilator-associated pneumonia (VAP) and cystic fibrosis (CF) as indications of the clinical potential of POL7001 to treat P. aeruginosa pulmonary infections...
August 2016: Antimicrobial Agents and Chemotherapy
A Taha, A Shafie, Y Lavoie, H Hubert, R Marktanner
No abstract text is available yet for this article.
December 2015: Intensive Care Medicine Experimental
A Roca-Biosca, L Rubio-Rico, M C Velasco-Guillen, L Anguera-Saperas
: A 69 year old man was admitted to the Intensive Care Unit (ICU) from the Emergency Department due to severe respiratory failure. Due to unsuccessful non-invasive mechanical ventilation, endotracheal intubation was performed. A category I ulcer in coccyx was detected 48h after admission. Eight hours later, a double erythema (the second one darker than the first one) with displacement between 30-45° over the bony prominence suggested there was a deep tissue injury. The lesion progressed rapidly during the next 24h...
May 21, 2016: Enfermería Intensiva
Yuqing Chen, Kewen Cheng, Xin Zhou
BACKGROUND Pressure support ventilation (PSV) is a standard method for non-invasive home ventilation. A bench study was designed to compare the effectiveness of patient-ventilator inspiratory termination synchronization with automated and conventional triggering in various respiratory mechanics models. MATERIAL AND METHODS Two ventilators, the Respironics V60 and Curative Flexo ST 30, connected to a Hans Rudolph Series 1101 lung simulator, were evaluated using settings that simulate lung mechanics in patients with chronic obstructive pulmonary disease (COPD), acute respiratory distress syndrome (ARDS), or normal lungs...
2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Kerry L Hedges, Merryn H Tawhai
One limitation of forced spirometry is that it integrates the contribution of the complex and dynamic behavior of all of the airways and tissue of the lung into a single exhaling unit, hence, it is not clear how spirometric measures are affected by local changes to the airways or tissue such as the presence of "ventilation defects." Here, we adapt a wave-speed limitation model to a spatially distributed and anatomically based airway tree that is embedded within a deformable parenchyma, to simulate forced expiration in 1 s (FEV1)...
June 2016: Journal of Biomechanical Engineering
Ahmadreza Yazdannik, Hadi Zarei, Gholamreza Massoumi
BACKGROUND: Different modes of mechanical ventilation are used for respiratory support after coronary artery bypass graft (CABG). This study aimed to compare the effect(s) of using adaptive support ventilation (ASV) and synchronized intermittent mandatory ventilation (SIMV) on the length of mechanical ventilation (intubation duration) and hospital stay after coronary artery bypass graft surgery. MATERIALS AND METHODS: In a randomized control trial, 64 patients were ventilated with ASV as the experiment group or with SIMV as the control group after CABG surgery in Chamran Hospital of Isfahan University of Medical Sciences...
March 2016: Iranian Journal of Nursing and Midwifery Research
R Nisha Aurora, Sabin R Bista, Kenneth R Casey, Susmita Chowdhuri, David A Kristo, Jorge M Mallea, Kannan Ramar, James A Rowley, Rochelle S Zak, Jonathan L Heald
An update of the 2012 systematic review and meta-analyses were performed and a modified-GRADE approach was used to update the recommendation for the use of adaptive servo-ventilation (ASV) for the treatment of central sleep apnea syndrome (CSAS) related to congestive heart failure (CHF). Meta-analyses demonstrated an improvement in LVEF and a normalization of AHI in all patients. Analyses also demonstrated an increased risk of cardiac mortality in patients with an LVEF of ≤ 45% and moderate or severe CSA predominant sleep-disordered breathing...
May 15, 2016: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
A Vieillard-Baron, M Matthay, J L Teboul, T Bein, M Schultz, S Magder, J J Marini
RATIONALE: Acute respiratory distress syndrome (ARDS) is frequently associated with hemodynamic instability which appears as the main factor associated with mortality. Shock is driven by pulmonary hypertension, deleterious effects of mechanical ventilation (MV) on right ventricular (RV) function, and associated-sepsis. Hemodynamic effects of ventilation are due to changes in pleural pressure (Ppl) and changes in transpulmonary pressure (TP). TP affects RV afterload, whereas changes in Ppl affect venous return...
May 2016: Intensive Care Medicine
M K P Tam, W T Wong, C D Gomersall, Q Tian, S K Ng, C C H Leung, M J Underwood
PURPOSE: This study aims to compare the effectiveness of weaning with adaptive support ventilation (ASV) incorporating progressively reduced or constant target minute ventilation in the protocol in postoperative care after cardiac surgery. MATERIAL AND METHODS: A randomized controlled unblinded study of 52 patients after elective coronary artery bypass surgery was carried out to determine whether a protocol incorporating a decremental target minute ventilation (DTMV) results in more rapid weaning of patients ventilated in ASV mode compared to a protocol incorporating a constant target minute ventilation...
June 2016: Journal of Critical Care
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"