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https://www.readbyqxmd.com/read/28328460/typhoid-fever
#1
Richard Barnett
No abstract text is available yet for this article.
November 19, 2016: Lancet
https://www.readbyqxmd.com/read/28323855/etiology-of-acute-diarrhea-in-the-elderly-in-china-a-six-year-observational-study
#2
Zike Zhang, Shengjie Lai, Jianxing Yu, Qibin Geng, Wanqi Yang, Yu Chen, Jianguo Wu, Huaiqi Jing, Weizhong Yang, Zhongjie Li
Acute diarrhea leads to a substantial disease burden among the elderly worldwide. However, in the context of increasingly aging trend in China, the prevalence of etiological agents among elderly diarrheal patients was undetermined. This study aimed to explore the major enteropathogens of acute diarrhea among outpatients older than 65 years in China, and also the epidemiological features of the pathogens. Demographic and clinical data for acute diarrhea among outpatients older than 65 years were collected from 213 participating hospitals from 2009 to 2014...
2017: PloS One
https://www.readbyqxmd.com/read/28306338/the-epidemiology-of-childhood-salmonella-infections-in-alberta-canada
#3
Kate E Faulder, Kimberley Simmonds, Joan L Robinson
OBJECTIVES: The objectives were to describe the incidence, demographics, laboratory findings, and suspected sources of childhood Salmonella infections in Alberta, Canada, with a focus on preventable cases. METHODS: Data from Notifiable Disease Reports for children with nontyphoidal salmonellosis (NTS) or typhoid/paratyphoid fever from 2007 through 2015 were analyzed. RESULTS: NTS was detected from 2285 children. Bacteremia was documented in 55 cases (2...
March 17, 2017: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/28303985/pattern-of-antimicrobial-drug-resistance-of-salmonella-typhi-and-paratyphi-a-in-a-teaching-hospital-in-islamabad
#4
Azmat Ali, Hafiz Awais Ali, Fazal Hussain Shah, Arslan Zahid, Hina Aslam, Benazir Javed
OBJECTIVE: To see the pattern of antimicrobial drug resistance among Salmonella serovars. METHODS: This longitudinal, observational study was conducted at Khan Research Laboratories Hospital, Islamabad, Pakistan, from May 2012 to December 2014. All patients presenting with typhoid fever with positive blood culture were included. Age, gender, salmonella serovar and sensitivity to 9 antimicrobial drugs were taken into account. The tested antimicrobial drugs were ampicillin, trimethoprim/sulphamethoxazole, chloramphenicol, nalidixic acid, ciprofloxacin, ofloxacin, levofloxacin, ceftriaxone and cefixime...
March 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28303138/importance-of-salmonella-typhi-responsive-cd8-t-cell-immunity-in-a-human-typhoid-fever-challenge-model
#5
Stephanie Fresnay, Monica A McArthur, Laurence S Magder, Thomas C Darton, Claire Jones, Claire S Waddington, Christoph J Blohmke, Brian Angus, Myron M Levine, Andrew J Pollard, Marcelo B Sztein
Typhoid fever, caused by the human-restricted organism Salmonella enterica serovar Typhi (S. Typhi), constitutes a major global health problem. The development of improved attenuated vaccines is pressing, but delayed by the lack of appropriate preclinical models. Herein, we report that high levels of S. Typhi-responsive CD8+ T cells at baseline significantly correlate with an increased risk of disease in humans challenged with a high dose (~10(4) CFU) wild-type S. Typhi. Typhoid fever development was associated with higher multifunctional S...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28296192/inferring-source-attribution-from-a-multiyear-multisource-data-set-of-salmonella-in-minnesota
#6
C Ahlstrom, P Muellner, S E F Spencer, S Hong, A Saupe, A Rovira, C Hedberg, A Perez, U Muellner, J Alvarez
Salmonella enterica is a global health concern because of its widespread association with foodborne illness. Bayesian models have been developed to attribute the burden of human salmonellosis to specific sources with the ultimate objective of prioritizing intervention strategies. Important considerations of source attribution models include the evaluation of the quality of input data, assessment of whether attribution results logically reflect the data trends and identification of patterns within the data that might explain the detailed contribution of different sources to the disease burden...
March 13, 2017: Zoonoses and Public Health
https://www.readbyqxmd.com/read/28295924/flagellin-phase-dependent-swimming-on-epithelial-cell-surfaces-contributes-to-productive-salmonella-gut-colonization
#7
Julia A Horstmann, Erik Zschieschang, Theresa Truschel, Juana de Diego, Michele Lunelli, Manfred Rohde, Tobias May, Till Strowig, Theresia Stradal, Michael Kolbe, Marc Erhardt
The flagellum is a sophisticated nanomachine and an important virulence factor of many pathogenic bacteria. Flagellar motility enables directed movements towards host cells in a chemotactic process and near surface swimming on cell surfaces is crucial for selection of permissive entry sites. The long external flagellar filament is made of tens of thousands subunits of a single protein, flagellin, and many Salmonella serovars alternate expression of antigenically distinct flagellin proteins, FliC and FljB. However, the role of the different flagellin variants during gut colonization and host cell invasion remains elusive...
March 13, 2017: Cellular Microbiology
https://www.readbyqxmd.com/read/28289725/cooperation-of-adhesin-alleles-in-salmonella-host-tropism
#8
Leon De Masi, Min Yue, Changmin Hu, Alexey V Rakov, Shelley C Rankin, Dieter M Schifferli
Allelic combinations and host specificities for three fimbrial adhesins, FimH, BcfD, and StfH, were compared for 262 strains of Salmonella enterica serovar Newport, a frequent human and livestock pathogen. Like FimH, BcfD had two major alleles (designated A and B), whereas StfH had two allelic groups, each with two alleles (subgroup A1 and A2 and subgroup B1 and B2). The most prevalent combinations of FimH/BcfD/StfH alleles in S. Newport were A/A/A1 and B/B/B1. The former set was most frequently found in bovine and porcine strains, whereas the latter combination was most frequently found in environmental and human isolates...
March 2017: MSphere
https://www.readbyqxmd.com/read/28289411/immunogenicity-of-a-bivalent-adjuvanted-glycoconjugate-vaccine-against-salmonella-typhimurium-and-salmonella-enteritidis
#9
Fabio Fiorino, Simona Rondini, Francesca Micoli, Luisa Lanzilao, Renzo Alfini, Francesca Mancini, Calman A MacLennan, Donata Medaglini
Salmonella enterica serovars Typhimurium and Enteritidis are the predominant causes of invasive non-typhoidal Salmonella (iNTS) disease. Considering the co-endemicity of S. Typhimurium and S. Enteritidis, a bivalent vaccine formulation against both pathogens is necessary for protection against iNTS disease, thus investigation of glycoconjugate combination is required. In the present work, we investigated the immune responses induced by S. Typhimurium and S. Enteritidis monovalent and bivalent glycoconjugate vaccines adjuvanted with aluminum hydroxide (alum) only or in combination with cytosine-phosphorothioate-guanine oligodeoxynucleotide (CpG)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28283139/incidences-of-waterborne-and-foodborne-diseases-after-meteorologic-disasters-in-south-korea
#10
Wonwoong Na, Kyeong Eun Lee, Hyung-Nam Myung, Soo-Nam Jo, Jae-Yeon Jang
BACKGROUND: Climate change could increase the number of regions affected by meteorologic disasters. Meteorologic disasters can increase the risk of infectious disease outbreaks, including waterborne and foodborne diseases. Although many outbreaks of waterborne diseases after single disasters have been analyzed, there have not been sufficient studies reporting comprehensive analyses of cases occurring during long-term surveillance after multiple disasters, which could provide evidence of whether meteorologic disasters cause infectious disease outbreaks...
September 2016: Annals of Global Health
https://www.readbyqxmd.com/read/28282600/determination-of-free-polysaccharide-in-vi-glycoconjugate-vaccine-against-typhoid-fever
#11
C Giannelli, E Cappelletti, R Di Benedetto, F Pippi, M Arcuri, V Di Cioccio, L B Martin, A Saul, F Micoli
Glycoconjugate vaccines based on the Vi capsular polysaccharide directed against Salmonella enterica serovar Typhi are licensed or in development against typhoid fever, an important cause of morbidity and mortality in developing countries. Quantification of free polysaccharide in conjugate vaccines is an important quality control for release, to monitor vaccine stability and to ensure appropriate immune response. However, we found that existing separation methods based on size are not appropriate as free Vi non-specifically binds to unconjugated and conjugated protein...
February 24, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28280021/whole-genome-shotgun-sequencing-of-cephalosporin-resistant-salmonella-enterica-serovar-typhi
#12
Camilla Rodrigues, Arti Kapil, Anita Sharma, Naveen Kumar Devanga Ragupathi, Francis Yesurajan Inbanathan, Balaji Veeraraghavan, Gagandeep Kang
Typhoid is one of the leading causes of mortality in developing countries. Here, we report the draft genome sequences of four Salmonella enterica serovar Typhi strains isolated from bloodstream infections in a tertiary care hospital. The sequence data indicate genomes of ~4.5 Mb for all isolates, with one plasmid in each.
March 9, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28277779/further-investigations-on-the-epidemiology-of-fowl-typhoid-in-brazil
#13
Anny Lucia Del Pilar Celis-Estupiñan, Diego Felipe Alves Batista, Marita Vedovelli Cardozo, Andrei Itajahy Secundo de Souza, Lucas Bocchini Rodrigues Alves, Adriana Maria de Almeida, Paul Andrew Barrow, Angelo Berchieri, Oliveiro Caetano de Freitas Neto
Salmonella Gallinarum (SG) causes fowl typhoid (FT), a disease responsible for economic losses to the poultry industry worldwide. FT has been considered under control in Brazil; nevertheless, since 2012 it has frequently been identified in poultry farming of several Brazilian states. The present study was aimed at assessing: (i) the pathogenicity of a SG strain recently isolated from an FT outbreak affecting chickens of both white and brown layers; (ii) the transmission of SG through eggs and hatching; (iii) the effects of antibiotic therapy on SG persistence in poultry tissues and on its vertical transmission; (iv) the genetic profiles of strains isolated over 27 years by PFGE...
March 1, 2017: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/28268075/vaccination-of-active-component-us-military-personnel-against-salmonella-typhi
#14
Chad K Porter, Tia Sorrell, Indrani Mitra, Mark S Riddle
INTRODUCTION: Vaccination against Salmonella Typhi is one of the leading public health interventions reducing the risk of typhoid fever. There are two available licensed vaccines, Vivotif, oral live-attenuated, and Typhim Vi, intramuscular Vi capsular polysaccharide. The US military is a high risk travel population commonly vaccinated for S. Typhi. We describe the use of S. Typhi vaccination in this population and the acute reactogenicity profile of these vaccines. METHODS: Data were obtained from the Defense Medical Surveillance System and vaccination identified between 1998 and 2011 from vaccination codes...
March 3, 2017: Vaccine
https://www.readbyqxmd.com/read/28264046/an-association-between-decreasing-incidence-of-invasive-non-typhoidal-salmonellosis-and-increased-use-of-antiretroviral-therapy-gauteng-province-south-africa-2003-2013
#15
Karen H Keddy, Simbarashe Takuva, Alfred Musekiwa, Adrian J Puren, Arvinda Sooka, Alan Karstaedt, Keith P Klugman, Frederick J Angulo
BACKGROUND: HIV-infected persons are at increased risk of opportunistic infections, including invasive nontyphoidal Salmonella (iNTS) infections; antiretroviral therapy (ART) reduces this risk. We explored changing iNTS incidence associated with increasing ART availability in South Africa. METHODS: Laboratory-based surveillance for iNTS was conducted in Gauteng Province, South Africa, with verification using the National Health Laboratory Service's Central Data Warehouse (CDW), between 2003 and 2013...
2017: PloS One
https://www.readbyqxmd.com/read/28260765/comparison-of-molecular-detection-method-nested-polymerase-chain-reaction-with-blood-culture-and-paired-widal-test-for-the-rapid-diagnosis-of-typhoid-fever
#16
S Khan, R A Miah, S Pal, S Khatun, N Fatema, R R Roy, C R Naheen
Typhoid fever is a major health problem in developing countries in spite of the use of antibiotics and the development of newer antibacterial drugs. Blood culture & serological tests (specially Widal test) which are invariably done in Bangladesh for typhoid fever diagnosis give unacceptable levels of false negative & false positive results respectively. This cross sectional study was done at Bangabandhu Sheikh Mujib Medical University from March 2013 to February 2014. In this study, a polymerase chain reaction-based technique (which has 100% specificity for Salmonella Typhi) was compared with blood culture and widal test among 80 clinically suspected cases of typhoid fever...
January 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28256469/epidemiological-investigation-of-an-outbreak-of-typhoid-fever-in-jorhat-town-of-assam-india
#17
Jashbeer Singh Roy, Lahari Saikia, Mithu Medhi, Dipak Tassa
BACKGROUND & OBJECTIVES: Typhoid fever is a global health problem and is also endemic in India. An outbreak of fever occurred in January 2014 in Jorhat Town in Assam, India. Here we report the results of an investigation done to find out the aetiology and source of the outbreak. METHODS: The affected areas were visited on January 23, 2014 by a team of Jorhat district Integrated Disease Surveillance Project personnel. A total of 13 blood samples from patients with fever as first symptom and six water samples were collected from the affected areas...
October 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28254988/draft-genome-sequence-of-salmonellaenterica-serovar-typhi-imr_tp298-15-a-strain-with-intermediate-susceptibility-to-ciprofloxacin-isolated-from-a-typhoid-outbreak
#18
Norazah Ahmad, Shirley Yi Fen Hii, Rohaidah Hashim, Rahizan Issa
Salmonella enterica serovar Typhi with reduced susceptibility to ciprofloxacin is increasingly being reported globally. An outbreak caused by Salmonella Typhi with decreased ciprofloxacin susceptibility has not been reported before in Malaysia. We present here the annotated draft genome of a Salmonella Typhi strain involved in a typhoid outbreak.
March 2, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28248674/prevalence-serotype-distribution-and-antimicrobial-resistance-of-salmonella-isolated-from-food-products-in-morocco
#19
Nadia Amajoud, Brahim Bouchrif, Mohammed El Maadoudi, Nadia Skalli Senhaji, Bouchra Karraouan, Abdeltif El Harsal, Jamal El Abrini
INTRODUCTION: Salmonellosis is one of the most common foodborne diseases worldwide. The irrational use of antibiotics in medicine and in animal feed has greatly promoted the emergence and spread of resistant strains of non-typhoidal Salmonella. METHODOLOGY: A total of 464 food products were collected in Tetouan from January 2010 to December 2012. The isolation and identification of Salmonella were performed according to Moroccan standard 08.0.116. All isolates were serotyped and were then tested for antibiotic resistance using the disk diffusion method...
February 28, 2017: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/28241011/the-burden-of-typhoid-fever-in-low-and-middle-income-countries-a-meta-regression-approach
#20
Marina Antillón, Joshua L Warren, Forrest W Crawford, Daniel M Weinberger, Esra Kürüm, Gi Deok Pak, Florian Marks, Virginia E Pitzer
BACKGROUND: Upcoming vaccination efforts against typhoid fever require an assessment of the baseline burden of disease in countries at risk. There are no typhoid incidence data from most low- and middle-income countries (LMICs), so model-based estimates offer insights for decision-makers in the absence of readily available data. METHODS: We developed a mixed-effects model fit to data from 32 population-based studies of typhoid incidence in 22 locations in 14 countries...
February 2017: PLoS Neglected Tropical Diseases
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