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https://www.readbyqxmd.com/read/28731899/current-perspectives-on-invasive-nontyphoidal-salmonella-disease
#1
Andrea H Haselbeck, Ursula Panzner, Justin Im, Stephen Baker, Christian G Meyer, Florian Marks
PURPOSE OF REVIEW: We searched PubMed for scientific literature published in the past 2 years for relevant information regarding the burden of invasive nontyphoidal Salmonella disease and host factors associated with nontyphoidal Salmonella infection and discuss current knowledge on vaccine development. The following search terms were used: Salmonella, non typhoidal/nontyphoidal, NTS, disease, bloodstream infection, invasive, sepsis/septicaemia/septicemia, bacteraemia/bacteremia, gastroenteritis, incidence, prevalence, morbidity, mortality, case fatality, host/risk factor, vaccination, and prevention/control...
July 20, 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/28730976/salmonella-intracellular-lifestyles-and-their-impact-on-host-to-host-transmission
#2
M Graciela Pucciarelli, Francisco García-Del Portillo
More than a century ago, infections by Salmonella were already associated with foodborne enteric diseases with high morbidity in humans and cattle. Intestinal inflammation and diarrhea are hallmarks of infections caused by nontyphoidal Salmonella serovars, and these pathologies facilitate pathogen transmission to the environment. In those early times, physicians and microbiologists also realized that typhoid and paratyphoid fever caused by some Salmonella serovars could be transmitted by "carriers," individuals outwardly healthy or at most suffering from some minor chronic complaint...
July 2017: Microbiology Spectrum
https://www.readbyqxmd.com/read/28727726/a-cross-sectional-seroepidemiological-survey-of-typhoid-fever-in-fiji
#3
Conall H Watson, Stephen Baker, Colleen L Lau, Kitione Rawalai, Mere Taufa, Jerimaia Coriakula, Nga Tran Vu Thieu, Tan Trinh Van, Dung Tran Thi Ngoc, Niel Hens, John Lowry, Ruklanthi de Alwis, Jorge Cano, Kylie Jenkins, E Kim Mulholland, Eric J Nilles, Mike Kama, W John Edmunds
Fiji, an upper-middle income state in the Pacific Ocean, has experienced an increase in confirmed case notifications of enteric fever caused by Salmonella enterica serovar Typhi (S. Typhi). To characterize the epidemiology of typhoid exposure, we conducted a cross-sectional sero-epidemiological survey measuring IgG against the Vi antigen of S. Typhi to estimate the effect of age, ethnicity, and other variables on seroprevalence. Epidemiologically relevant cut-off titres were established using a mixed model analysis of data from recovering culture-confirmed typhoid cases...
July 20, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28723869/chronic-disseminated-salmonellosis-in-a-patient-with-interleukin-12p40-deficiency
#4
Emadia Mohammad Alaki, Fahad Aljobair, Faisal Alaklobi, Mobarak Al Shamrani, Fahad Al-Zahim, Aziza Dongues, Jean-Laurent Casanova
Interleukin (IL)-12 is composed of p35 and p40 subunit, in this case IL-12p40 deficiency is a rare genetic etiology of Mendelian susceptibility to mycobacterial disease (MSMD). Salmonellosis has been reported in almost half of these patients and mostly present in recurrent extra intestinal form. In this report, we described an 18 month old boy with absence of IL12p40 production suffering from chronic disseminated non-typhoidal salmonellosis. To the best of our knowledge this is the first reported case.
July 18, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28720886/spatio-temporal-variations-of-typhoid-and-paratyphoid-fevers-in-zhejiang-province-china-from-2005-to-2015
#5
Hua Gu, Wenjie Fan, Kui Liu, Shuwen Qin, Xiuyang Li, Jianmin Jiang, Enfu Chen, Yibiao Zhou, Qingwu Jiang
Typhoid and paratyphoid are two common enteric infectious diseases with serious gastrointestinal symptoms. Data was collected of the registered cases in Zhejiang Province from 2005 to 2015. The epidemiological characteristics were investigated and high-risk regions were detected with descriptive epidemiological methods and in-depth spatio-temporal statistics. A sharp decline in the incidences of both diseases was observed. The seasonal patterns were identified with typhoid and paratyphoid, one in summer from May to September was observed from 2005 to 2010 and the other lesser one in spring from January to March only observed from 2005 to 2007...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28720030/rose-spots-following-oral-typhoid-vaccine
#6
Kelly O'Connor, Russell W Steele
No abstract text is available yet for this article.
August 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/28719502/safety-of-quadrivalent-meningococcal-conjugate-vaccine-in-children-2-10-years
#7
Sara Y Tartof, Lina S Sy, Bradley K Ackerson, Rulin C Hechter, Mendel Haag, Jeffrey M Slezak, Yi Luo, Christine A Fischetti, Harp S Takhar, Yan Miao, Zendi Solano, Steven J Jacobsen, Hung-Fu Tseng
BACKGROUND: Quadrivalent meningococcal conjugate vaccine is recommended for children, adolescents, and adults at increased risk of meningococcal disease. In 2011, MenACWY-CRM (Menveo, GSK) was approved for children aged 2-10 years in the U.S. Although no safety concerns arose from clinical trials, it remains important to monitor its safety in routine clinical settings. METHODS: Kaiser Permanente Southern California members 2-10 years old who received MenACWY-CRM between September 2011 and September 2014 were included...
July 14, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28718270/salmonella-infection-amongst-food-workers-in-lahore
#8
Sajjad Ullah, Saira Bashir, Akif Qasim
This descriptive observational study was conducted at Pathology lab Jinnah hospital, Lahore, January 2013 to October 2015. We include all the food workers in different restaurants, slaughters, inn, recreation centre and bakeries of Lahore for the purpose to identify the salmonella infection, we used Typhoid IgGI/IgM Rapid test device methods (Serum/Plasma), is a lateral flow chromatographic immunoassay technique were calculated. We analysed 1025 individuals, 62 (6%) were found positive for the said diseases out of which 14 (1...
April 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28717307/traditional-treatment-of-human-and-animal-salmonelloses-in-southern-benin-knowledge-of-farmers-and-traditherapists
#9
T V Dougnon, E Déguénon, L Fah, B Lègba, Y M G Hounmanou, J Agbankpè, A Amadou, H Koudokpon, K Fabiyi, A Aniambossou, P Assogba, E Hounsa, M de Souza, F Avlessi, T J Dougnon, F Gbaguidi, M Boko, H S Bankolé, L Baba-Moussa
AIM: This study aimed to report medicinal plants that are likely to be used in the control of salmonellosis. MATERIALS AND METHODS: A cross-sectional study was conducted in Southern Benin. Semi-structured questionnaires were administered to 150 farmers and 100 traditional therapists in seven high municipalities. This step helped to collect plants that are used in the treatment of animal salmonellosis and typhoid fever in human. RESULTS: The results revealed a low level of use of medicinal plants among breeders who prefer antibiotics such as oxytetracycline (53...
June 2017: Veterinary World
https://www.readbyqxmd.com/read/28695217/death-and-the-media-infectious-disease-reporting-during-the-health-transition
#10
Dora L Costa, Matthew E Kahn
In the late 19th Century, cities in Western Europe and the United States suffered from high levels of infectious disease. Over a 40 year period, there was a dramatic decline in infectious disease deaths in cities. As such objective progress in urban quality of life took place, how did the media report this trend? At that time newspapers were the major source of information educating urban households about the risks they faced. By constructing a unique panel data base, we find that news reports were positively associated with government announced typhoid mortality counts and the size of this effect actually grew after the local governments made large investments in public water works to reduce typhoid rates...
July 2017: Economica
https://www.readbyqxmd.com/read/28692655/population-based-incidence-seasonality-and-serotype-distribution-of-invasive-salmonellosis-among-children-in-nanoro-rural-burkina-faso
#11
Issa Guiraud, Annelies Post, Seydou Nakanabo Diallo, Palpouguini Lompo, Jessica Maltha, Kamala Thriemer, Christian Marc Tahita, Benedikt Ley, Karim Derra, Emmanuel Bottieau, Adama Kazienga, Céline Schurmans, Raffaella Ravinetto, Eli Rouamba, Johan Van Griensven, Sophie Bertrand, Halidou Tinto, Jan Jacobs
BACKGROUND: Bloodstream infections (BSI) caused by Salmonella Typhi and invasive non-Typhoidal Salmonella (iNTS) frequently affect children living in rural sub-Saharan Africa but data about incidence and serotype distribution are rare. OBJECTIVE: The present study assessed the population-based incidence of Salmonella BSI and severe malaria in a Health and Demographic Surveillance System in a rural area with seasonal malaria transmission in Nanoro, Burkina Faso. METHODS: Children between 2 months-15 years old with severe febrile illness were enrolled during a one-year surveillance period (May 2013-May 2014)...
2017: PloS One
https://www.readbyqxmd.com/read/28681816/clinical-and-laboratory-profile-of-dengue-viral-infections-in-and-around-mangalore-india
#12
Tina Damodar, Meena Dias, Reeta Mani, K A Shilpa, Ashwini Manoor Anand, V Ravi, Jutang Tiewsoh
BACKGROUND: Dengue (DEN) is being recognised as the world's major emerging tropical disease. Clinically, DEN may resemble other infections such as malaria, leptospirosis, and typhoid, and thus, laboratory investigations are required for definitive diagnosis. Secondary DEN infection, caused most often by dengue virus (DENV) serotypes 2 and 3, is known to present with severe disease manifestations. This study was undertaken to examine the clinical and laboratory profile of DEN viral infections and to determine the circulating serotypes in and around Mangalore, India...
April 2017: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28676794/bacteriophages-contribute-to-the-spread-of-antibiotic-resistance-genes-among-foodborne-pathogens-of-the-enterobacteriaceae-family-a-review
#13
REVIEW
Anna Colavecchio, Brigitte Cadieux, Amanda Lo, Lawrence D Goodridge
Foodborne illnesses continue to have an economic impact on global health care systems. There is a growing concern regarding the increasing frequency of antibiotic resistance in foodborne bacterial pathogens and how such resistance may affect treatment outcomes. In an effort to better understand how to reduce the spread of resistance, many research studies have been conducted regarding the methods by which antibiotic resistance genes are mobilized and spread between bacteria. Transduction by bacteriophages (phages) is one of many horizontal gene transfer mechanisms, and recent findings have shown phage-mediated transduction to be a significant contributor to dissemination of antibiotic resistance genes...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28675263/specific-and-cross-reactive-plasmablast-response-in-humans-after-primary-and-secondary-immunization-with-vi-capsular-polysaccharide-typhoid-vaccine
#14
Sari H Pakkanen, Jussi M Kantele, Lars Rombo, Anu Kantele
Secondary immunization with polysaccharide vaccines may imply a risk of hyporesponsiveness. Despite the wide use of typhoid Vi capsular polysaccharide vaccine, its potential tendency to hyporesponsiveness has been inadequately addressed. While previous studies have explored serum antibody responses, we applied a more sensitive approach, a single-cell assay for circulating plasmablasts, to compare primary and secondary responses. Twelve subjects received primary and booster doses of the Vi vaccine (Typherix(®)) at 30-37-month intervals...
July 3, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28674312/molecular-subtyping-of-salmonella-enterica-serovar-typhi-by-pulsed-field-gel-electrophoresis-and-multiple-locus-variable-number-tandem-repeat-analysis-in-india-their-association-with-antimicrobial-resistance-profiles
#15
Surojit Das, Sriparna Samajpati, Indranil Roy, Sathish Sankar, Rajni Gaind, Monorama Deb, Raghavendra Kulkarni, Dilip Kumar Paul, Shanta Dutta
Molecular subtyping, and recently DNA sequencing based methods, which are commonly used for discriminating Salmonella enterica serovar Typhi (S. Typhi) isolates, leads to improved molecular epidemiological investigations for prevention and control of typhoid fever. We included S. Typhi blood isolates (n=66) from India during 2007-14 for molecular subtyping by pulsed-field gel electrophoresis (PFGE) and multiple-locus variable-number tandem-repeat (VNTR) analysis (MLVA) in association with antibiotic resistance profiles...
July 1, 2017: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28674145/the-strataa-study-protocol-a-programme-to-assess-the-burden-of-enteric-fever-in-bangladesh-malawi-and-nepal-using-prospective-population-census-passive-surveillance-serological-studies-and-healthcare-utilisation-surveys
#16
Thomas C Darton, James E Meiring, Susan Tonks, Md Arifuzzaman Khan, Farhana Khanam, Mila Shakya, Deus Thindwa, Stephen Baker, Buddha Basnyat, John D Clemens, Gordon Dougan, Christiane Dolecek, Sarah J Dunstan, Melita A Gordon, Robert S Heyderman, Kathryn E Holt, Virginia E Pitzer, Firdausi Qadri, K Zaman, Andrew J Pollard
INTRODUCTION: Invasive infections caused by Salmonella enterica serovar Typhi and Paratyphi A are estimated to account for 12-27 million febrile illness episodes worldwide annually. Determining the true burden of typhoidal Salmonellae infections is hindered by lack of population-based studies and adequate laboratory diagnostics.The Strategic Typhoid alliance across Africa and Asia study takes a systematic approach to measuring the age-stratified burden of clinical and subclinical disease caused by typhoidal Salmonellae infections at three high-incidence urban sites in Africa and Asia...
July 2, 2017: BMJ Open
https://www.readbyqxmd.com/read/28663369/structure-and-function-analyses-of-a-pertussis-like-toxin-from-pathogenic-escherichia-coli-reveal-a-distinct-mechanism-of-inhibition-of-trimeric-g-proteins
#17
Dene R Littler, Sheng Y Ang, Danilo G Moriel, Martina Kocan, Oded Kleifeld, Mathew D Johnson, Mai T Tran, Adrienne W Paton, James C Paton, Roger Summers, Mark Schrembri, Jamie Rossjohn, Travis T Beddoe
Pertussis-like toxins are secreted by several bacterial pathogens during infection. They belong to the AB5 virulence factors, which bind to glycans on host cell membranes for internalization. Host cell recognition and internalization are mediated by toxin B subunits sharing a unique pentameric ring-like assembly. While the role of pertussis toxin in whooping cough is well established, pertussis-like toxins produced by other bacteria are less studied and their mechanisms of action are unclear. Here, we report that some extra-intestinal Escherichia coli pathogens (i...
June 29, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28658831/enteric-cholestatic-hepatitis-with-ascites-a-rare-entity
#18
Samarth Virmani, Rama Bhat, Raghavendra Rao, Savio Dsouza, Nitin Bhat
Typhoid fever is a very common illness in developing countries. Patients most often present with a history of fever, vomiting, anorexia, abdominal pain, etc. Rarely there is hepatic involvement due to the disease process. This is a case report of a 26-year-old male who had presented with fever, jaundice and ascites. The widal titres were found to be within normal limits (1:80) however the patient was found to have Salmonella typhi on ascitic fluid culture. The patient was treated with the appropriate antibiotics and was later discharged...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28656014/the-role-of-typhoid-toxin-in-salmonella-typhi-virulence%C3%A2
#19
REVIEW
Alexander Chong, Sohyoung Lee, Yi-An Yang, Jeongmin Song
Unlike many of the nontyphoidal Salmonella serovars such as S. Typhimurium that cause restricted gastroenteritis, Salmonella Typhi is unique in that it causes life-threatening typhoid fever in humans. Despite the vast difference in disease outcomes that S. Typhi and S. Typhimurium cause in humans, there are few genomic regions that are unique to S. Typhi. Of these regions, the most notable is the small locus encoding typhoid toxin, an AB toxin that has several distinct characteristics that contribute to S. Typhi's pathogenicity...
June 2017: Yale Journal of Biology and Medicine
https://www.readbyqxmd.com/read/28653456/detecting-ebola-with-limited-laboratory-access-in-the-democratic-republic-of-congo-evaluation-of-a-clinical-passive-surveillance-reporting-system
#20
Hayley R Ashbaugh, Brandon Kuang, Adva Gadoth, Vivian H Alfonso, Patrick Mukadi, Reena H Doshi, Nicole A Hoff, Cyrus Sinai, Mathias Mossoko, Benoit Ilunga Kebela, Jean-Jacques Muyembe, Emile Okitolonda Wemakoy, Anne W Rimoin
BACKGROUND: Ebola Virus Disease (EVD) can be clinically severe and highly fatal, making surveillance efforts for early disease detection of paramount importance. In areas with limited access to laboratory testing, the Integrated Disease Surveillance and Response (IDSR) strategy in the Democratic Republic of Congo (DRC) may be a vital tool in improving outbreak response. METHODS: Using DRC IDSR data from the nation's four EVD outbreak periods from 2007-2014, we assessed trends of Viral Hemorrhagic Fever (VHF) and EVD differential diagnoses reportable through IDSR...
June 27, 2017: Tropical Medicine & International Health: TM & IH
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