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https://www.readbyqxmd.com/read/28430751/rhabdomyolysis-complicating-typhoid-fever-in-a-child-and-review-of-the-literature
#1
Peter James Snelling, Paul Moriarty, Vikram L Vaska, David Levitt, Clare Nourse
Typhoid fever is an important cause of morbidity and mortality in the developing world, particularly in children, but is infrequently observed in the developed world and can occur in patients without a significant travel history. Rhabdomyolysis as a complication has rarely been reported, and never in a child. A child with Salmonella enterica serovar typhi septicemia, complicated by rhabdomyolysis, encephalopathy and pancreatitis is described and all 15 reported cases to date are summarized.
April 19, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28428924/a-case-report-of-salmonella-muenchen-enteritis-causing-rhabdomyolysis-and-myocarditis-in-a-previously-healthy-26-year-old-man
#2
Will Chapple, Jon Martell, Joy S Wilson, Don T Matsuura
This case report examines an unusual presentation of a non-typhoidal Salmonella serovar with limited prevalence in the literature. This is the first case report to associate specifically the Salmonella muenchen serovar with rhabdomyolysis and myocarditis. This case report reviews the diagnostic criteria for myocarditis and explores the diagnostic dilemma of troponin elevation in the setting of rhabdomyolysis. It demonstrates that Salmonella muenchen has the ability to present in a broad range of individuals with complications extending beyond classical gastrointestinal symptoms...
April 2017: Hawai'i Journal of Medicine & Public Health: a Journal of Asia Pacific Medicine & Public Health
https://www.readbyqxmd.com/read/28428786/challenge-of-humans-with-wild-type-salmonella-enterica-serovar-typhi-elicits-changes-in-the-activation-and-homing-characteristics-of-mucosal-associated-invariant-t-cells
#3
Rosângela Salerno-Goncalves, David Luo, Stephanie Fresnay, Laurence Magder, Thomas C Darton, Claire Jones, Claire S Waddington, Christoph J Blohmke, Brian Angus, Myron M Levine, Andrew J Pollard, Marcelo B Sztein
Gastrointestinal infections by Salmonella enterica serovar Typhi (S. Typhi) are rare in industrialized countries. However, they remain a major public health problem in the developing world with an estimated 26.9 million new cases annually and significant mortality when untreated. Recently, we provided the first direct evidence that CD8(+) MAIT cells are activated and have the potential to kill cells exposed to S. Typhi, and that these responses are dependent on bacterial load. However, MAIT cell kinetics and function during bacterial infections in humans remain largely unknown...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28416464/microbiological-quality-of-water-in-a-city-with-persistent-and-recurrent-waterborne-diseases-under-tropical-sub-rural-conditions-the-case-of-kikwit-city-democratic-republic-of-the-congo
#4
Alexis B Nienie, Periyasamy Sivalingam, Amandine Laffite, Patience Ngelinkoto, Jean-Paul Otamonga, Alphonse Matand, Crispin K Mulaji, Emmanuel M Biey, Pius T Mpiana, John Poté
The availability of safe drinking water in sub-Saharan countries remains a major challenge because poor sanitation has been the cause of various outbreaks of waterborne disease due to the poor microbiological quality of water used for domestic purposes. The faecal indicator bacteria (FIB) used in the present study included Escherichia coli (E. coli) and Enterococcus (ENT). FIB and aerobic mesophilic bacteria (AMB) were quantified during July 2015 (dry season) and November 2015 (rainy season) in order to assess the quality of drinking water from wells (n=3; P1-P3), and two rivers, the River Lukemi (RLK, n=3) and River Luini (RLN, n=2) in the city of Kikwit, which is located in the province of Kwilu in the Democratic Republic of the Congo...
March 30, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28406420/epidemiological-clinical-and-therapeutic-features-of-typhoid-intestinal-perforation-in-a-rural-environment-of-burkina-faso
#5
S Ouedraogo, E Ouangre, M Zida
The aim of this study was to describe the epidemiological, clinical, and therapeutic features of ileal perforation due to typhoid fever at the regional hospital of Tenkodogo (Burkina Faso). This cross-sectional study examined the records over a 5-year period of all patients treated for typhoid ileal perforation. Ileal perforation was diagnosed intraoperatively, and its typhoid origin determined according to the following criteria : background signs of typhoid fever, location of the perforation on the antimesenteric edge of the terminal ileum, and a positive Widal-Felix serology...
February 1, 2017: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/28406162/mucosal-iga-and-ifn-%C3%AE-cd8-t-cell-immunity-are-important-in-the-efficacy-of-live-salmonella-enteria-serovar-choleraesuis-vaccines
#6
Liangquan Zhu, Xinxin Zhao, Qing Yin, Xianyong Liu, Xiang Chen, Chunjuan Huang, Xun Suo
Salmonellosis, a disease caused by non-typhoidal Salmonella strains which can be transmitted from swine to humans, is one of the leading public health problems around the world. Paratyphoid of swine is controlled by vaccinating swine with Salmonella enterica serovar Choleraesuis (S. Choleraesuis) live vaccine strain C500 in China. Although the vaccine has good prophylactic efficacy, the mechanism of immunogenicity is unclear. Using a C500-derived paratyphoid thermo-stable live vaccine (PTSL vaccine), we demonstrated that the PTSL vaccine induces strong primary and memory immune responses in piglets...
April 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28405476/bilateral-retinitis-following-typhoid-fever
#7
M Prabhushanker, Tasneem T Topiwalla, Geetha Ganesan, Sripal Appandaraj
BACKGROUND: Post typhoid fever immune related reactions affecting the eye is a rare finding which can have various presentations in which typhoid retinopathy is not a well recognized sequelae. CASE PRESENTATION: Here we present a case of 59 year old male who presented with right eye sudden painless loss of vision 4 weeks after typhoid fever which was diagnosed and treated successfully. His BCVA was 2/60 in right eye and 6/6 in left eye. Fundus examination showed retinitis along with macular serous detachment in right eye and retinitis in left eye...
2017: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/28405072/tularemia-presenting-as-pulmonary-nodules-in-an-immunocompromised-patient
#8
Tony Alias, Mohammad Kazem Fallahzadeh, Mezgebe Berhe
Tularemia is a zoonotic disease caused by Francisella tularensis that can be transmitted to humans when they handle rabbits, receive tick bites, consume contaminated water, or inhale aerosolized particles. We present the case of a 51-year-old white man with rheumatoid arthritis who was taking immunosuppressive medications and presented with tularemia. Our patient acquired the typhoidal form of tularemia, which is a severe systemic illness that manifests with fevers, headaches, myalgias, vomiting, diarrhea, and neurological symptoms, due to his immunocompromised state...
April 2017: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/28405025/high-avidity-iga-protects-the-intestine-by-enchaining-growing-bacteria
#9
Kathrin Moor, Médéric Diard, Mikael E Sellin, Boas Felmy, Sandra Y Wotzka, Albulena Toska, Erik Bakkeren, Markus Arnoldini, Florence Bansept, Alma Dal Co, Tom Völler, Andrea Minola, Blanca Fernandez-Rodriguez, Gloria Agatic, Sonia Barbieri, Luca Piccoli, Costanza Casiraghi, Davide Corti, Antonio Lanzavecchia, Roland R Regoes, Claude Loverdo, Roman Stocker, Douglas R Brumley, Wolf-Dietrich Hardt, Emma Slack
Vaccine-induced high-avidity IgA can protect against bacterial enteropathogens by directly neutralizing virulence factors or by poorly defined mechanisms that physically impede bacterial interactions with the gut tissues ('immune exclusion'). IgA-mediated cross-linking clumps bacteria in the gut lumen and is critical for protection against infection by non-typhoidal Salmonella enterica subspecies enterica serovar Typhimurium (S. Typhimurium). However, classical agglutination, which was thought to drive this process, is efficient only at high pathogen densities (≥10(8) non-motile bacteria per gram)...
April 12, 2017: Nature
https://www.readbyqxmd.com/read/28388624/development-of-a-glycoconjugate-vaccine-to-prevent-invasive-salmonella-typhimurium-infections-in-sub-saharan-africa
#10
Scott M Baliban, Mingjun Yang, Girish Ramachandran, Brittany Curtis, Surekha Shridhar, Rachel S Laufer, Jin Y Wang, John Van Druff, Ellen E Higginson, Nicolas Hegerle, Kristen M Varney, James E Galen, Sharon M Tennant, Andrew Lees, Alexander D MacKerell, Myron M Levine, Raphael Simon
Invasive infections associated with non-typhoidal Salmonella (NTS) serovars Enteritidis (SE), Typhimurium (STm) and monophasic variant 1,4,[5],12:i:- are a major health problem in infants and young children in sub-Saharan Africa, and currently, there are no approved human NTS vaccines. NTS O-polysaccharides and flagellin proteins are protective antigens in animal models of invasive NTS infection. Conjugates of SE core and O-polysaccharide (COPS) chemically linked to SE flagellin have enhanced the anti-COPS immune response and protected mice against fatal challenge with a Malian SE blood isolate...
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28384119/status-of-water-pollution-in-relation-to-industrialization-in-rajasthan
#11
Ritu Singh Rajput, Sonali Pandey, Seema Bhadauria
India is a large and densely populated country; its economy is largely agricultural. Making the best use of the country's manpower has always posed a challenge. Industrialization could become a dominant component of the economy and displace agriculture. Traditional livelihoods of occupational groups are threatened by the practice of disposing untreated industrial waste into rivers and bodies of water. These uncontrolled disposals impact local natural resources with negative long-term effects. Industrialization is the development of intellectual and financial trade that changes a predominantly rustic culture into a modern one...
April 6, 2017: Reviews on Environmental Health
https://www.readbyqxmd.com/read/28373758/typhoid-intestinal-perforation-in-developing-countries-still-unavoidable-deaths
#12
EDITORIAL
Sandro Contini
Typhoid fever is a public health challenge mostly concentrated in impoverished, overcrowded areas of the developing world, with lack of safe drinking and sanitation. The most serious complication is typhoid intestinal perforation (TIP), observed in 0.8% to 39%, with a striking rate difference between high-income and low-middle-income countries. Although the mortality rate consequent to TIP in resource-poor countries is improved in the last decades, it is still fluctuating from 5% to 80%, due to surgical- and not surgical-related constraints...
March 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28367881/epidemiological-characteristics-and-clinical-treatment-outcome-of-typhoid-fever-in-ningbo-china-2005-2014-pfge-results-revealing-great-proportion-of-common-transmission-sources
#13
Qifa Song, Yuanbin Yang, Wenping Lin, Bo Yi, Guozhang Xu
We aimed to describe the molecular epidemiological characteristics and clinical treatment outcome of typhoid fever in Ningbo, China, 2005-2014. Eighty-eight Salmonella Typhi isolates were obtained from 307 admitted patients. Three prevalent pulsed-field gel electrophoresis (PFGE) patterns of 54 isolates in 3 outbreaks were identified. Overall, there were 64 (72.7%) isolates from cases in clusters and 24 (27.3%) isolates from sporadic cases. Resistance to nalidixic acid (n=47; 53.4%) and ampicillin (n=40; 45...
March 28, 2017: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28358796/yellow-fever-outbreak-kongo-central-province-democratic-republic-of-the-congo-august-2016
#14
John O Otshudiema, Nestor G Ndakala, Elande-Taty K Mawanda, Gaston P Tshapenda, Jacques M Kimfuta, Loupy-Régence N Nsibu, Abdou S Gueye, Jacob Dee, Rossanne M Philen, Coralie Giese, Christopher S Murrill, Ray R Arthur, Benoit I Kebela
On April 23, 2016, the Democratic Republic of the Congo's (DRC's) Ministry of Health declared a yellow fever outbreak. As of May 24, 2016, approximately 90% of suspected yellow fever cases (n = 459) and deaths (45) were reported in a single province, Kongo Central Province, that borders Angola, where a large yellow fever outbreak had begun in December 2015. Two yellow fever mass vaccination campaigns were conducted in Kongo Central Province during May 25-June 7, 2016 and August 17-28, 2016. In June 2016, the DRC Ministry of Health requested assistance from CDC to control the outbreak...
March 31, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28357372/bacterial-genotoxin-functions-as-immune-modulator-and-promotes-host-survival
#15
COMMENT
R Guidi, L Del Bell Belluz, T Frisan
Bacterial genotoxins are effectors that cause DNA damage in target cells. Many aspects of the biology of these toxins have been characterised in vitro, such as structure, cellular internalisation pathways and effects on the target cells. However, little is known about their function in vivo. Salmonella enterica serovar Typhi (S. Typhi) is a Gram-negative, intracellular bacterium that causes typhoid fever, a debilitating disease infecting more than 20 million people every year. S. Typhiproduce a genotoxin named typhoid toxin (TT), but its role in the contest of host infection is poorly characterized...
July 28, 2016: Microbial Cell
https://www.readbyqxmd.com/read/28352651/clinical-virological-and-biological-parameters-associated-with-outcomes-of-ebola-virus-infection-in-macenta-guinea
#16
Marie-Astrid Vernet, Stéphanie Reynard, Alexandra Fizet, Justine Schaeffer, Delphine Pannetier, Jeremie Guedj, Max Rives, Nadia Georges, Nathalie Garcia-Bonnet, Aboubacar I Sylla, Péma Grovogui, Jean-Yves Kerherve, Christophe Savio, Sylvie Savio-Coste, Marie-Laure de Séverac, Philippe Zloczewski, Sandrine Linares, Souley Harouna, Bing M'Lebing Abdoul, Frederic Petitjean, Nenefing Samake, Susan Shepherd, Moumouni Kinda, Fara Roger Koundouno, Ludovic Joxe, Mathieu Mateo, Patrick Lecine, Audrey Page, Tang Maleki Tchamdja, Matthieu Schoenhals, Solenne Barbe, Bernard Simon, Tuan Tran-Minh, Christophe Longuet, François L'Hériteau, Sylvain Baize
BACKGROUND. The pathogenesis of Ebola virus (EBOV) disease (EVD) is poorly characterized. The establishment of well-equipped diagnostic laboratories close to Ebola treatment centers (ETCs) has made it possible to obtain relevant virological and biological data during the course of EVD and to assess their association with the clinical course and different outcomes of the disease. METHODS. We were responsible for diagnosing EBOV infection in patients admitted to two ETCs in forested areas of Guinea. The pattern of clinical signs was recorded, and an etiological diagnosis was established by RT-PCR for EBOV infection or a rapid test for malaria and typhoid fever...
March 23, 2017: JCI Insight
https://www.readbyqxmd.com/read/28352198/antimicrobial-susceptibility-profile-treatment-outcome-and-serotype-distribution-of-clinical-isolates-of-salmonella-enterica-subspecies-enterica-a-2-year-study-from-kerala-south-india
#17
Deepa Harichandran, Kavitha Radhakrishnan Dinesh
BACKGROUND/PURPOSE: Typhoid and paratyphoid fever continue to be important causes of illness and death in parts of Asia, being associated with poor sanitation and consumption of unsafe food and water. Antimicrobial resistance has emerged to traditional first-line drugs, namely, the fluoroquinolones, as well as to third-generation cephalosporins, posing challenges to treatment. Azithromycin has proven to be an effective alternative for treatment of uncomplicated typhoid fever. The purpose of this study was to determine the antimicrobial susceptibility, clinical outcome and serotype distribution pattern of clinical isolates belonging to Salmonella enterica subspecies enterica...
2017: Infection and Drug Resistance
https://www.readbyqxmd.com/read/28344395/characterization-of-salmonella-gallinarum-from-an-outbreak-in-raigarh-chhattisgarh
#18
Chandrahas Sannat, Anil Patyal, Nidhi Rawat, R C Ghosh, D K Jolhe, R K Shende, S D Hirpurkar, Sanjay Shakya
AIM: The present investigation was conducted to isolate and characterize Salmonella Gallinarum from an outbreak of fowl typhoid in layer birds. MATERIALS AND METHODS: Clinically ill and dead layer birds from an outbreak were investigated. History, clinical signs, and postmortem lesions were suggestive of fowl typhoid. Postmortem samples including heart blood, intestinal contents, pieces of ovary, and liver were collected and processed immediately for bacterial culture, serotyping and antibiotic sensitivity tests...
February 2017: Veterinary World
https://www.readbyqxmd.com/read/28344124/comparative-genomics-of-transport-proteins-in-probiotic-and-pathogenic-escherichia-coli-and-salmonella-enterica-strains
#19
Jimmy Do, Hassan Zafar, Milton H Saier
Escherichia coli is a genetically diverse species that can be pathogenic, probiotic, commensal, or a harmless laboratory strain. Pathogenic strains of E. coli cause urinary tract infections, diarrhea, hemorrhagic colitis, and pyelonephritis, while the two known probiotic E. coli strains combat inflammatory bowel disease and play a role in immunomodulation. Salmonella enterica, a close relative of E. coli, includes two important pathogenic serovars, Typhi and Typhimurium, causing typhoid fever and enterocolitis in humans, respectively, with the latter strain also causing a lethal typhoid fever-like disease in mice...
March 24, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28328460/typhoid-fever
#20
Richard Barnett
No abstract text is available yet for this article.
November 19, 2016: Lancet
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