Venkata K Yellepeddi, Jonathan A Race, Mary M McFarland, Jonathan E Constance, Elika Fanaeian, Nancy A Murphy
OBJECTIVES: To describe the efficacy of atropine in controlling salivary flow in patients with sialorrhea or drooling. MATERIALS AND METHODS: We included randomized controlled studies, quasi-randomized trials, case reports, clinical trials, systematic reviews, and meta-analyses assessing the use of atropine in patients with sialorrhea or drooling. The endpoints were reduction in salivary flow rate, amount of saliva secreted, reduction in clinical symptoms of sialorrhea, death rattle intensity, or reduction in drooling intensity as measured by an objective scale such as the drooling intensity scale...
April 5, 2024: International Journal of Clinical Pharmacology and Therapeutics