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fgid ibs database

Claudio Romano, Simona Valenti, Sabrina Cardile, Marc A Benninga
As defined by Rome III, there are four abdominal pain-related functional gastrointestinal disorders (FGIDs) in children: irritable bowel syndrome (IBS), functional dyspepsia (FD), abdominal migraine, and functional abdominal pain (FAP). Dyspepsia is a constellation of symptoms referable to the gastroduodenal region of the upper gastrointestinal tract. FD refers to dyspeptic symptoms that cannot currently be explained by an organic cause, and affects 25-40% of the adult population over a lifetime. In children, this condition results in increased specialist consultations, with reported prevalence between 3%-27%...
July 20, 2016: Journal of Pediatric Gastroenterology and Nutrition
R Park, S Mikami, J LeClair, A Bollom, C Lembo, S Sethi, A Lembo, M Jones, V Cheng, E Friedlander, S Nurko
BACKGROUND: Functional gastrointestinal disorders (FGIDs) are among the most common outpatient diagnoses in pediatric primary care and gastroenterology. There is limited data on the inpatient burden of childhood FGIDs in the USA. The aim of this study was to evaluate the inpatient admission rate, length of stay (LoS), and associated costs related to FGIDs from 1997 to 2009. METHODS: We analyzed the Kids' Inpatient Sample Database (KID) for all subjects in which constipation (ICD-9 codes: 564...
May 2015: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
Juliette M T M Rutten, Judith J Korterink, Leonie M A J Venmans, Marc A Benninga, Merit M Tabbers
BACKGROUND AND OBJECTIVE: Various nonpharmacologic treatments are available for pediatric abdominal pain-related functional gastrointestinal disorders (AP-FGIDs). Data on efficacy and safety are scarce. The goal of this study was to summarize the evidence regarding nonpharmacologic interventions for pediatric AP-FGIDs: lifestyle interventions, dietary interventions, behavioral interventions, prebiotics and probiotics, and alternative medicine. METHODS: Searches were conducted of the Medline and Cochrane Library databases...
March 2015: Pediatrics
A C Ford, N J Talley, M M Walker, M P Jones
BACKGROUND: There is increasing evidence that impaired mucosal defence mechanisms are implicated in the pathogenesis of the functional gastrointestinal disorders (FGIDs), allowing inappropriate immune activation. AIM: To test the hypothesis that an excess of autoimmune disorders among sufferers, using a large primary care database to examine this. METHODS: Cases were diagnosed with FGIDs - irritable bowel syndrome (IBS), functional dyspepsia (FD), chronic idiopathic constipation (CIC), and multiple FGIDs...
October 2014: Alimentary Pharmacology & Therapeutics
Max Schmulson, Mopelola Adeyemo, Gabriela Gutiérrez-Reyes, Luis Charúa-Guindic, Blanca Farfán-Labonne, Feggy Ostrosky-Solis, Adriana Díaz-Anzaldúa, Laura Medina, Lin Chang
OBJECTIVES: Irritable bowel syndrome (IBS), constipation, and bloating are more prevalent in women than men, but gender differences associated with dyspepsia are inconsistent.The aim of this study was to determine gender differences in the prevalence of symptoms diagnostic for functional gastrointestinal disorders (FGIDs) in subjects with IBS and dyspepsia, as well as in controls in Mexico. METHODS: A database of 1,021 subjects (61% women) who completed the Rome II Modular Questionnaire (RIIMQ) in Spanish Mexico was analyzed...
April 2010: American Journal of Gastroenterology
N Manabe, B S Wong, M Camilleri, D Burton, S McKinzie, A R Zinsmeister
BACKGROUND Abnormalities of colonic motility were reported in relatively small studies of patients with lower functional gastrointestinal disorders (FGID) including irritable bowel syndrome (IBS). The influence of gender and body mass on the observed motor pathophysiology is unclear. We sought to compare colonic transit in patients within different lower FGID subgroups and healthy controls, controlling for gender and BMI, and to determine whether BMI independently influences colonic motility. METHODS We evaluated a scintigraphic gastrointestinal and colonic transit database of 287 lower FGID patients associated with constipation (IBS-C, or functional constipation, n = 118), diarrhoea (IBS-D or functional diarrhoea, n = 139) or mixed bowel function (IBS-M, n = 30) and 170 healthy controls...
March 2010: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
A B M Grudell, M Camilleri, P Carlson, H Gorman, M Ryks, D Burton, K Baxter, A R Zinsmeister
Adrenergic and serotonergic mechanisms alter human gut motor functions. Genotype variation influences phenotype. Our aim was to test the hypothesis that variation in genes that control these functions is associated with gastrointestinal (GI) motor functions in humans with functional GI disorders (FGID). A database of 251 people was assembled by combining genotype data with measurements of gut transit and gastric volumes. Genetic variations evaluated were: alpha(2A) adrenergic (C-1291G), alpha(2C) (Del 332-325), 5-HT transporter (SLC6A4) and GNbeta3 (C825T)...
March 2008: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
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