keyword
MENU ▼
Read by QxMD icon Read
search

Animal model

keyword
https://www.readbyqxmd.com/read/29929213/gut-microbiome-in-type-1-diabetes-a-comprehensive-review
#1
REVIEW
Peilin Zheng, Zhixia Li, Zhiguang Zhou
Type 1 diabetes (T1D) is an autoimmune disease, which is characterized by the destruction of islet β cells in the pancreas triggered by genetic and environmental factors. In past decades, extensive familial and genome-wide association studies have revealed more than 50 risk loci in the genome. However, genetic susceptibility cannot explain the increased incidence of T1D worldwide, which is very likely attributed by the growing impact of environmental factors, especially gut microbiome. Recently, the role of gut microbiome in the pathogenesis of T1D have been uncovered by the increasing evidence from both human subjects and animal models, strongly indicating that gut microbiome might be a pivotal hub of T1D-triggering factors, especially environmental factors...
June 21, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29929194/statins-and-thyroid-carcinoma-a-meta-analysis
#2
Junyu Zhao, Chunmei Xu, Jinming Yao, Changzhen Yu, Lin Liao, Jianjun Dong
BACKGROUND/AIMS: Experimental studies have reported the antineoplastic effects of statins in thyroid carcinoma; however, observational studies suggested that statins might increase the risk of thyroid carcinoma. Therefore, this study evaluated the antineoplastic effects of statins in both in vitro studies and animal models, as well as the epidemiological evidence. METHODS: Databases-PubMed, Cochrane Library, SinoMed, CNKI, Wanfang, and clinical trial registries- were searched...
June 19, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29929183/pre-clinical-evaluation-of-novel-mucoadhesive-bilayer-patches-for-local-delivery-of-clobetasol-17-propionate-to-the-oral-mucosa
#3
H E Colley, Z Said, M E Santocildes-Romero, S R Baker, K D'Apice, J Hansen, L Siim Madsen, M H Thornhill, P V Hatton, C Murdoch
Oral lichen planus (OLP) and recurrent aphthous stomatitis (RAS) are chronic inflammatory conditions often characterised by erosive and/or painful oral lesions that have a considerable impact on quality of life. Current treatment often necessitates the use of steroids in the form of mouthwashes, creams or ointments, but these are often ineffective due to inadequate drug contact times with the lesion. Here we evaluate the performance of novel mucoadhesive patches for targeted drug delivery. Electrospun polymeric mucoadhesive patches were produced and characterised for their physical properties and cytotoxicity before evaluation of residence time and acceptability in a human feasibility study...
June 14, 2018: Biomaterials
https://www.readbyqxmd.com/read/29929167/a-survey-on-chimeric-ureb-229-561-hpaa-protein-targeting-helicobacter-pylori-computational-and-in-vitro-urease-activity-valuation
#4
Alireza Salimi Chirani, Mona Ghazi, Mehdi Goudarzi, Shahin Najar Peerayeh, Hoorieh Soleimanjahi, Masoud Dadashi, Bahareh Hajikhani
Helicobacter pylori (H. pylori) as microaerophilic, Gram-negative bacterium colonize the human gastric milieu, where it impetuses chronic disorders. Vaccination is a complementary plan, along with antibiotic therapy, for clearance of H. pylori. Today, Computer based tools are essential for the evaluation, design, and experiment for novel chimeric targets for immunological administration. The purpose of this experiment was immunoinformatic analysis of UreB and HpaA molecules in a fusion arrangement and also, construction and expression of recombinant protein containing chimeric sequences...
May 5, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29929140/terra-incognita-the-unknown-risks-to-environmental-quality-posed-by-the-spatial-distribution-and-abundance-of-concentrated-animal-feeding-operations
#5
Katherine L Martin, Ryan E Emanuel, James M Vose
Concentrated animal feeding operations (CAFOs) pose wide ranging environmental risks to many parts of the US and across the globe, but datasets for CAFO risk assessments are not readily available. Within the United States, some of the greatest concentrations of CAFOs occur in North Carolina. It is also one of the only states with publicly accessible location data for classes of CAFOs that are required to obtain water quality permits from the U.S. Environmental Protection Agency (EPA); however, there are no public data sources for the large number of CAFOs that do not require EPA water quality permits...
June 18, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29929115/matched-pair-86-y-90-y-labeled-bivalent-rgd-bombesin-antagonist-rgd-glu-do3a-6-ahx-rm2-as-a-potential-theranostic-agent-for-prostate-cancer
#6
Nilantha Bandara, Tamila J Stott Reynolds, Rebecca Schehr, Rajendra P Bandari, Philipp J Diebolder, Stephanie Krieger, Jingli Xu, Yubin Miao, Buck E Rogers, Charles J Smith
INTRODUCTION: In this study, we describe development of a true matched-pair theranostic agent that is able to target the αV β3 integrin and the gastrin releasing peptide receptor (GRPR). We herein describe methods to metallate and characterize the new conjugate and to validate its biological efficacy by in vitro and in vivo methods. METHODS: We have previously described the development of [RGD-Glu-6Ahx-RM2] (where RGD: Arg-Gly-Asp; Glu: glutamic acid; 6-Ahx: 6-amino hexanoic acid; RM2: (D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH2)) that has been conjugated to a DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) bifunctional chelating agent (BFCA) to afford [RGD-Glu-[DO3A]-6-Ahx-RM2] peptide...
June 8, 2018: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29929098/kcnj6-girk2-trisomy-is-not-sufficient-for-conferring-the-susceptibility-to-infantile-spasms-seen-in-the-ts65dn-mouse-model-of-down-syndrome
#7
Krutika Joshi, Lily Shen, Feng Cao, Susan Dong, Zhengping Jia, Miguel A Cortez, O Carter Snead
OBJECTIVE: Infantile spasms (IS) is a catastrophic childhood seizure disorder that is characterized by extensor and/or flexor spasms, cognitive deterioration and a characteristic EEG abnormality. The latter consists of a pattern of a spike-wave followed by an electrodecremental response (EDR), which is a flattening of the EEG waveform amplitude. The mechanism/circuitry that underpins IS is unknown. Children with Down Syndrome (DS) are particularly vulnerable to IS. The standard mouse model of DS is the Ts65Dn mutant mouse (Ts)...
June 12, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29929009/safety-immunogenicity-and-protection-of-a-h3n2-live-attenuated-influenza-vaccines-containing-wild-type-nucleoprotein-in-a-ferret-model
#8
Daniil A Korenkov, Karen L Laurie, Patrick C Reading, Louise A Carolan, Kok Fei Chan, Irina I Isakova-Sivak, Tatiana A Smolonogina, Kanta Subbarao, Ian G Barr, Julie Villanueva, Svetlana Shcherbik, Tatiana Bousse, Larisa G Rudenko
Live attenuated influenza vaccines (LAIVs) are promising tools for the induction of broad protection from influenza due to their ability to stimulate cross-reactive T cells against influenza pathogens. One of the major targets for cytotoxic T-cell immunity is viral nucleoprotein (NP), which is relatively conserved among antigenically distant influenza viruses. Nevertheless, a diversity of epitope composition has been found in the NP protein of different lineages of influenza A viruses. The H2N2 master donor virus which is currently used as a backbone for the LAIV and donor of the six genomic segments encoding the internal proteins, A/Leningrad/134/17/57 (MDV Len/17), was isolated 60 years ago...
June 18, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29928964/spinal-interleukin-10-produces-antinociception-in-neuropathy-through-microglial-%C3%AE-endorphin-expression-separated-from-antineuroinflammation
#9
Hai-Yun Wu, Xiao-Fang Mao, Xue-Qi Tang, Usman Ali, Evhy Apryani, Hao Liu, Xin-Yan Li, Yong-Xiang Wang
Interleukin 10 (IL-10) is antinociceptive in various animal models of pain without induction of tolerance, and its mechanism of action was generally believed to be mediated by inhibition of neuroinflammation. Here we reported that intrathecal IL-10 injection dose dependently attenuated mechanical allodynia and thermal hyperalgesiain male and female neuropathic rats, with ED50 values of 40.8 ng and 24 ng, and Emax values of 61.5% MPE and 100% MPE in male rats. Treatment with IL-10 specifically increased expression of the β-endorphin (but not prodynorphin) gene and protein in primary cultures of spinal microglia but not in astrocytes or neurons...
June 18, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29928950/contingency-training-alters-neurobiological-components-of-emotional-resilience-in-male-and-female-rats
#10
M Kent, S Scott, S Lambert, E Kirk, B Terhune-Cotter, B Thompson, S Neal, B Dozier, M Bardi, K Lambert
Prior research with a rat model of behavioral therapy [i.e., effort-based reward (EBR) contingency training] suggests that strengthened associations between physical effort and desired outcomes enhance neurobiological indices of resilience. In the current study, male and female Long-Evans rats were exposed to either six weeks of EBR training or noncontingent training prior to 10 days of exposure to chronic unpredictable stress (CUS). Subsequently, all animals were exposed to a problem-solving task and then trained in a spatial learning/foraging task, the dry land maze (DLM)...
June 18, 2018: Neuroscience
https://www.readbyqxmd.com/read/29928921/paucigranulocytic-asthma-the-uncoupling-of-airway-obstruction-from-inflammation
#11
Omar Tliba, Reynold A Panettieri
Among patients with asthma, heterogeneity exists regarding the pattern of airway inflammation and response to treatment, prompting the necessity of recognizing specific phenotypes. Based on the analysis of inflammatory cell count in induced sputum, patients with asthma can be classified in four unique phenotypes; eosinophilic, neutrophilic, mixed granulocytic, and paucigranulocytic asthma (PGA). PGA is an asthma phenotype with no evidence of elevated numbers of eosinophils or neutrophils in sputum or blood, and in which anti-inflammatory therapies are ineffective in controlling symptoms...
June 18, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29928890/dynamic-regulation-of-brain-aromatase-and-isotocin-receptor-gene-expression-depends-on-parenting-status
#12
Ross DeAngelis, Logan Dodd, Amanda Snyder, Justin S Rhodes
Fathering behavior is critical for offspring survival in many species across diverse taxa, but our understanding of the neuroendocrine mechanisms regulating paternal care is limited in part because of the few primarily paternal species among the common animal models. However, many teleosts display primarily paternal care, and among the teleosts, anemonefish species are particularly well suited for isolating molecular mechanisms of fathering as they perform parental care in isolation of many other typically competing behaviors such as territorial defense and nest building...
June 18, 2018: Hormones and Behavior
https://www.readbyqxmd.com/read/29928758/interactions-between-large-and-small-detritivores-influence-how-biodiversity-impacts-litter-decomposition
#13
Alan M Tonin, Jesús Pozo, Silvia Monroy, Ana Basaguren, Javier Pérez, José F Gonçalves, Richard Pearson, Bradley J Cardinale, Luz Boyero
1. Understanding how biodiversity loss influences plant litter decomposition - i.e., the biologically mediated conversion of coarse to fine particulate organic matter - is crucial to predict changes in the functioning of many stream ecosystems, where detrital food webs are dominant. Rates of litter decomposition are influenced by detritivore diversity, but the mechanisms behind this relationship are uncertain. 2. As differences in detritivore body size are a major determinant of interspecific interactions, they should be key for predicting effects of detritivore diversity on decomposition...
June 21, 2018: Journal of Animal Ecology
https://www.readbyqxmd.com/read/29928743/reproduction-numbers-of-infectious-disease-models
#14
REVIEW
Pauline van den Driessche
This primer article focuses on the basic reproduction number, <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:msub> <mml:mi>ℛ</mml:mi> <mml:mn>0</mml:mn> </mml:msub> </mml:mrow> </mml:math> , for infectious diseases, and other reproduction numbers related to <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:msub> <mml:mi>ℛ</mml:mi> <mml:mn>0</mml:mn> </mml:msub> </mml:mrow> </mml:math> that are useful in guiding control strategies...
August 2017: Infectious Disease Modelling
https://www.readbyqxmd.com/read/29928742/spatiotemporal-epidemic-models-for-rabies-among-animals
#15
REVIEW
Shigui Ruan
Rabies is a serious concern to public health and wildlife management worldwide. Over the last three decades, various mathematical models have been proposed to study the transmission dynamics of rabies. In this paper we provide a mini-review on some reaction-diffusion models describing the spatial spread of rabies among animals. More specifically, we introduce the susceptible-exposed-infectious models for the spatial transmission of rabies among foxes (Murray et al., 1986), the spatiotemporal epidemic model for rabies among raccoons (Neilan and Lenhart, 2011), the diffusive rabies model for skunk and bat interactions (Bonchering et al...
August 2017: Infectious Disease Modelling
https://www.readbyqxmd.com/read/29928660/rho-kinase-inhibitors-do-not-expand-hematoma-volume-in-acute-experimental-intracerebral-hemorrhage
#16
Murtaza Akhter, Tom Qin, Paul Fischer, Homa Sadeghian, Hyung Hwan Kim, Michael J Whalen, Joshua N Goldstein, Cenk Ayata
Rho-associated kinase (ROCK) is an emerging target in acute ischemic stroke. Early pre-hospital treatment with ROCK inhibitors may improve their efficacy, but their antithrombotic effects raise safety concerns in hemorrhagic stroke, precluding use prior to neuroimaging. Therefore, we tested whether ROCK inhibition affects the bleeding times, and worsens hematoma volume in a model of intracerebral hemorrhage (ICH) induced by intrastriatal collagenase injection in mice. Tail bleeding time was measured 1 h after treatment with isoform-nonselective inhibitor fasudil, or ROCK2-selective inhibitor KD025, or their vehicles...
June 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29928462/hot-topics-from-the-assemblies
#17
(no author information available yet)
Tissue-resident alveolar macrophages (TR-AM) are depleted from the lung during the early stages of bleomycin-induced lung injury and fibrosis. The recovery of the population of macrophages after bleomycin could be completely attributable to the recruitment and differentiation of monocyte-derived alveolar macrophages (Mo-AM). The authors used multiple lineage-trace mouse models where they selectively depleted TR-AM or Mo-AM and induced fibrosis with bleomycin. Deletion of TR-AM had no effect on the severity of the fibrotic phenotype...
December 2017: Breathe
https://www.readbyqxmd.com/read/29928406/experimental-animal-study-of-docetaxel-combined-with-carboplatin-in-the-treatment-of-retinoblastoma
#18
Caiping Song, Qiang Zhang
The synergistic effects of docetaxel (DTX) combined with carboplatin in the treatment of retinoblastoma (RB) was explored in mouse RB xenografts compared with carboplatin alone and DTX alone groups. Retinoblastoma Y-79 cells (4.0×107 /ml) were injected into the vitreous body of the right eye of mice to establish the mouse model of RB xenografts. Then the mice were randomly divided into 4 groups (n=30): DTX combined with carboplatin group (group A), carboplatin group (group B), DTX group (group C) and blank control group (group D)...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928368/differences-between-epithelial-and-mesenchymal-human-tongue-cancer-cell-lines-in-experimental-metastasis
#19
Wei-Xin Cai, Ru Qing Yu, Li Ma, Hong Zhang Huang, Li Wu Zheng, Roger Zwahlen
Distant metastasis represents the outcome with the worst prognosis for various types of malignant tumors, but little is known regarding the impact of interacting epithelial and mesenchymal phenotypic cancer cells within its etiopathogenesis. In a novel animal model, 48 male athymic Balb/c nude mice underwent subcutaneous and intravenous injection of human tongue cancer cell lines of green fluorescent mesenchymal and red fluorescent epithelial phenotypes, in order to visualize and monitor eventual phenotypic interaction in lung metastasis as well as experimental metastasis in in vivo, ex vivo and histopathological analyses...
June 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928319/canine-mammary-tumors-as-a-model-for-human-disease
#20
REVIEW
Somaia M Abdelmegeed, Sulma Mohammed
Animal models for examining human breast cancer (HBC) carcinogenesis have been extensively studied and proposed. With the recent advent of immunotherapy, significant attention has been focused on the dog as a model for human cancer. Dogs develop mammary tumors and other cancer types spontaneously with an intact immune system, which exhibit a number of clinical and molecular similarities to HBC. In addition to the spontaneous tumor presentation, the clinical similarities between human and canine mammary tumors (CMT) include the age at onset, hormonal etiology and course of the diseases...
June 2018: Oncology Letters
keyword
keyword
31804
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"