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https://www.readbyqxmd.com/read/27909889/long-term-results-of-a-modified-expansion-sphincter-pharyngoplasty-for-sleep-disordered-breathing
#1
Anne-Sophie Despeghel, Lisabeth Mus, Catherine Dick, Stephan Vlaminck, Rudolf Kuhweide, Bob Lerut, Kato Speleman, Anne-Sophie Vinck, Tom Vauterin
Our aim was to evaluate the long-term objective and subjective results of a modified expansion sphincter pharyngoplasty (ESP) technique in patients with sleep-disordered breathing. Single center prospective study of 35 patients underwent an ESP as a primary surgical treatment between June 2012 and September 2015 at the hospital AZ Sint-Jan Bruges-Ostend. Patients were divided into non-OSAS and OSAS (AHI >5). Primary outcome parameters were the Epworth Sleeping Scale (ESS, reduction and score less then 10) and the Visual Analogue Score of snoring (VAS, assessed by partner) evaluated at 3 months and 1 year...
December 1, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27908233/procedure-for-purification-of-recombinant-premsk1p-from-e-coli-determines-its-properties-as-a-factor-of-trna-import-into-yeast-mitochondria
#2
E V Smirnova, I V Chicherin, M V Baleva, N S Entelis, I A Tarassov, P A Kamenski
Mitochondrial genomes of many eukaryotic organisms do not code for the full tRNA set necessary for organellar translation. Missing tRNA species are imported from the cytosol. In particular, one out of two cytosolic lysine tRNAs of the yeast Saccharomyces cerevisiae is partially internalized by mitochondria. The key protein factor of this process is the precursor of mitochondrial lysyl-tRNA synthetase, preMsk1p. In this work, we show that recombinant preMsk1p purified from E. coli in native conditions, when used in an in vitro tRNA import system, demonstrates some properties different from those shown by the renatured protein purified from E...
October 2016: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/27907042/role-of-platelet-parameters-on-neovascular-glaucoma-a-retrospective-case-control-study-in-china
#3
Shengjie Li, Wenjun Cao, Xinghuai Sun
PURPOSE: Retinal vein occlusion (RVO) and diabetic retinopathy (DR) are two major sight-threatening diseases which may lead to neovascular glaucoma (NVG). The aim of this study was to explore the association between platelet parameters and NVG. METHODS: A total of 185 subjects were enrolled for the study from January, 2012 to December, 2015 at the Eye-ENT Hospital of Fudan University. Patients include those with NVG secondary to RVO (RVO group, n = 38), patients with NVG secondary to DR (DR group, n = 47), diabetics mellitus without retinopathy (DM group, n = 52), and healthy individuals (control group, n = 48)...
2016: PloS One
https://www.readbyqxmd.com/read/27903040/tonsillotomy-an-alternative-surgical-option-to-total-tonsillectomy-in-children-with-obstructive-sleep-apnoea
#4
Sabin Smith
BACKGROUND: Total tonsillectomy remains one of the most common ear, nose and throat (ENT) procedures performed in children. General practitioners (GPs) are commonly involved in the referral of children with obstructive sleep apnoea (OSA). Intracapsular tonsilltomy (partial tonsillectomy) is fast becoming a popular surgical option to total tonsillectomy in children with OSA. OBJECTIVE: The objective of this article is to provide information about partial tonsillectomy and its potential benefits over total tonsillectomy in the treatment of children with OSA for referring GPs...
December 2016: Australian Family Physician
https://www.readbyqxmd.com/read/27901329/comparing-incidence-of-emergence-delirium-between-sevoflurane-and-desflurane-in-children-following-routine-otolaryngology-procedures
#5
Jeremy N Driscoll, Brian M Bender, Carlos A Archilla, Carol M Klim, J Hossain, George Mychaskiw, Julie L Wei
BACKGROUND: Emergence delirium (ED) is a state of aggressive agitation that can occur temporarily in the process of emerging from anesthesia in children exposed to volatile or intravenous anesthetics. Emergence delirium is typically assessed using the published and validated pediatric emergence delirium (PAED) scale. Due to some variation in properties between sevoflurane and desflurane for maintenance of anesthesia after standard sevoflurane induction, we designed a prospective study to examine potential differences in emergence behavior and incidence of ED in children undergoing elective ear-nose-throat (ENT) surgery...
November 30, 2016: Minerva Anestesiologica
https://www.readbyqxmd.com/read/27899519/initial-clinical-experience-using-the-two-stage-aspiration-technique-tsat-with-proximal-flow-arrest-by-a-balloon-guiding-catheter-for-acute-ischemic-stroke-of-the-anterior-circulation
#6
Hiroyuki Matsumoto, Hirokazu Nishiyama, Yoshiaki Tetsuo, Hideki Takemoto, Naoyuki Nakao
BACKGROUND: Our initial experience using the two-stage aspiration technique (TSAT) with proximal flow arrest by a balloon guiding catheter is presented. In TSAT, aspiration is applied with the 5MAX ACE and also with the 3MAX catheter with a Penumbra aspiration pump, while arresting proximal flow by balloon inflation. METHODS: In patients treated with TSAT, clinical data including National Institutes of Health Stroke Scale (NIHSS) score at admission and the modified Rankin Scale (mRS) score at discharge, as well as procedural data including the Thrombolysis in Cerebral Infarction (TICI) score, procedural time, and complications were analyzed...
November 29, 2016: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/27890872/effect-of-astigmatism-on-refraction-in-children-with-high-hyperopia
#7
Hao Hu, Jinhui Dai, Minjie Chen, Lanting Chen, Lingli Jiang, Ran Lin, Ling Wang
The aim of this study was to evaluate primitively whether the extent and component of astigmatism influences regression in degree of spherical (DS) and the best corrected visual acuity (BCVA) of children with hyperopia of +5.00 diopters (D) or greater. Children were screened from the outpatient refraction database in the Wenling No. 1 People's Hospital in Zhejiang province and in Eye & ENT Hospital of Fudan University between June 2005 and December 2015. Eligible eyes were divided into three groups according to the extent of astigmatism: group of astigmatism ≤ -2 D of cylinder, group without astigmatism or with astigmatism ≥ -0...
November 27, 2016: Drug Discoveries & Therapeutics
https://www.readbyqxmd.com/read/27888123/acute-rhinosinusitis-during-hajj-season-2014-prevalence-of-bacterial-infection-and-patterns-of-antimicrobial-susceptibility
#8
Osama A Marglani, Ameen Z Alherabi, Islam R Herzallah, Faisal A Saati, Enas A Tantawy, Talal A Alandejani, Hani S Faidah, Naif A Bawazeer, Abdullah A Marghalani, Tariq A Madani
BACKGROUND: The presence of large number of pilgrims during Hajj in Makkah region increases the risk of respiratory diseases. In this study, we aimed to assess the bacteriology of acute rhinosinusitis (ARS) during Hajj season and to demonstrate the antimicrobial susceptibility patterns that should guide the clinicians towards more appropriate antibiotic use. METHODS: Patients with ARS presenting during Hajj season of 2014 were prospectively enrolled. According to EPOS2012 criteria...
November 23, 2016: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/27886000/evaluation-of-corrosion-resistance-and-surface-characteristics-of-orthodontic-wires-immersed-in-different-mouthwashes
#9
Didem Nalbantgil, Feyza Ulkur, Gulfeza Kardas, Mustafa Culha
BACKGROUND: Patients use mouthwashes in addition to mechanical cleaning during orthodontic treatment. The effects of mouthwashes on the archwires have not been examined yet. OBJECTIVE: To compare the corrosion resistance of four different arch wires and corrosion effects of different mouthwashes to formulate a biocompatible and mechanically useful arch wire and mouthwash combination. METHODS: Each group comprised of 4 wire samples of 2 cm 0...
November 25, 2016: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/27885599/characterization-of-high-affinity-iron-acquisition-systems-in-campylobacter-jejuni
#10
Ximin Zeng, Jun Lin
Iron acquisition systems are critical for bacterial pathogenesis and thus have been proposed as attractive targets for iron-dependent pathogen control. Of these systems, high-affinity iron acquisition mediated by siderophore, a small iron chelator, is the most efficient iron-scavenging mechanism in gram-negative bacteria. Campylobacter does not produce any siderophores but has the ability to utilize exogenous siderophores. In particular, the enterobactin (Ent)-mediated iron scavenging is tightly linked to Campylobacter pathogenesis...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27879981/zinc-supplementation-for-tinnitus
#11
REVIEW
Osmar C Person, Maria Es Puga, Edina Mk da Silva, Maria R Torloni
BACKGROUND: Tinnitus is the perception of sound without external acoustic stimuli. Patients with severe tinnitus may have physical and psychological complaints and their tinnitus can cause deterioration in their quality of life. At present no specific therapy for tinnitus has been found to be satisfactory in all patients. In recent decades, a number of reports have suggested that oral zinc supplementation may be effective in the management of tinnitus. Since zinc has a role in cochlear physiology and in the synapses of the auditory system, there is a plausible mechanism of action for this treatment...
November 23, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27876735/-the-basic-principles-underlying-the-provision-of-the-urgent-and-emergency-medical-assistance-in-otorhionolaryngology
#12
V T Pal'chun
The peculiarities of the clinical course of ENT pathologies are considered with special reference to the associated life-threatening conditions. The basic principles underlyi ng the provision of the urgent and emergency medical assistance in the otorhionolaryngological practice are discussed.
2016: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/27876727/-specific-immunotherapy-applied-in-the-otorhionolaryngological-practice
#13
R G Gadzhimirzaeva, G A Gadzhimirzaev, E G Gamzatova, Kh M Asadulaeva
The objective of the present study was to formulate the indications for the specific immunotherapy (SIT) of ENT diseases based on the results of the examination and treatment of 1058 patients presenting with allergic rhinitis with special reference to the advantages of this approach over pharmacotherapy. Much attention is given to the adverse reactions associated with the application of immunotherapy and the methods for their correction. Personal opinions of the authors with regard to selected aspects of the use of specific immunotherapy in the otorhionolaryngological practice are presented...
2016: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/27876300/functional-voice-disorders-the-importance-of-the-psychologist-in-clinical-voice-assessment
#14
Mafalda Andrea, Óscar Dias, Mário Andrea, Maria Luísa Figueira
OBJECTIVES: The etiopathogenesis of functional voice disorders (FVDs) is multifactorial. The purpose of this study was to analyze the severity of depression and anxiety, and the incidence of affective and anxiety disorders, in patients who presented different types of FVDs and were followed at the University Clinic of Otolaryngology. DESIGN: This is a cross-sectional study. METHODS: After ENT observation, 83 women were classified into three groups: psychogenic voice disorder (PVD = 39), primary muscle tension voice disorder (MTVD1 = 16), and secondary muscle tension voice disorder (MTVD2 = 28)...
November 18, 2016: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/27872953/a-phase-i-study-of-afatinib-combined-with-paclitaxel-and-bevacizumab-in-patients-with-advanced-solid-tumors
#15
James Spicer, Sheeba Irshad, Joo Ern Ang, Deborah Enting, Rebecca Kristeleit, Martina Uttenreuther-Fischer, Karine Pemberton, Katy Pelling, David Schnell, Johann de Bono
PURPOSE: The combination of afatinib, an irreversible ErbB family blocker, with paclitaxel and bevacizumab was assessed in patients with advanced solid tumors. METHODS: This phase I study used a 3 + 3 design to determine the maximum tolerated dose (MTD) of afatinib combined with paclitaxel and bevacizumab. Safety, pharmacokinetics, and anti-tumor activity were also assessed. The starting dose was oral afatinib 40 mg once daily plus intravenous paclitaxel (fixed dose 80 mg/m(2), Days 1, 8, and 15 of a 4-week cycle) and intravenous bevacizumab 5 mg/kg every 2 weeks...
November 21, 2016: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/27870813/acute-otitis-media-during-infancy-parent-reported-incidence-and-modifiable-risk-factors
#16
Annemarijn C Prins-van Ginkel, Patricia C J Bruijning-Verhagen, Cuno S P M Uiterwaal, Cornelis K van der Ent, Henriette A Smit, Marieke L A de Hoog
BACKGROUND: Age at exposure to acute otitis media (AOM) risk factors such as daycare attendance, lack of breastfeeding and tobacco smoke is little studied but important for targeting AOM prevention strategies. Moreover, studies are typically restricted to clinically diagnosed AOM, while a significant subset can occur outside the healthcare system, depending on the country-setting. This study aims to determine risk factor exposure and effect of its timing within the first year of life on parent-reported AOM symptom episodes...
November 18, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27870310/paradoxical-increase-in-nasal-airway-resistance-after-topical-nasal-decongestion-does-it-really-exist-a-retro-and-prospective-study
#17
S Swoboda, H L Thulesius, M Jessen
OBJECTIVE: To explore the prevalence and reproducibility of paradoxically increased nasal airway resistance after decongestion of the nasal mucosa as well as to identify patient-related factors associated with it. DESIGN: Retrospective analysis of all rhinomanometric measurements carried out at one ENT department in Sweden in the time between 1990 and 2010. In the baseline material, 207 of 4435 patients (4.7%) showed a paradoxically increased nasal airway resistance >20%...
December 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/27865008/biosynthesis-of-the-psychotropic-plant-diterpene-salvinorin-a-discovery-and-characterization-of-the-salvia-divinorum-clerodienyl-diphosphate-synthase
#18
Kyle A Pelot, Rod Mitchell, Moonhyuk Kwon, David M Hagelthorn, Jacob F Wardman, Angela Chiang, Jörg Bohlmann, Dae-Kyun Ro, Philipp Zerbe
Salvia divinorum commonly known as diviner's sage, is an ethnomedicinal plant of the mint family (Lamiaceae). S. divinorum is rich in clerodane-type diterpenoids, which accumulate predominantly in leaf glandular trichomes. The main bioactive metabolite, salvinorin A, is the first non-nitrogenous natural compound known to function as an opioid-receptor agonist, and is undergoing clinical trials for potential use in treating neuropsychiatric diseases and drug addictions. We report here the discovery and functional characterization of two S...
November 19, 2016: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/27863620/paediatric-airway-foreign-body-the-human-factors-influencing-patient-safety-in-our-hospitals
#19
O C Okonkwo, A Simons, J Nichani
Foreign bodies in the pediatric airway are an uncommon emergency with a high morbidity and mortality rate. Morbidity ranges from 10 to 20% worldwide and this pathology accounts for up to 7% of accidental deaths in children under 4. Dealing with this emergency safely and effectively is complex, requiring a tight coupling of procedures and processes and optimal anesthetic and operating conditions to prevent errors. These factors are recognized by the World Health Organization as 'Human Factors'. We perform a multi-center assessment of human factors pertinent to this emergency...
December 2016: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/27863415/induction-of-the-mitochondria-mediated-apoptosis-in-human-esophageal-cancer-cells-by-ds2-a-newly-synthetic-diterpenoid-analog-is-regulated-by-bax-and-caused-by-generation-of-reactive-oxygen-species
#20
Yong-Cheng Ma, Yu Ke, Xiaolin Zi, Fei Zhao, Lin Yuan, Ying-Li Zhu, Xia-Xia Fan, Ning-Min Zhao, Qiao-Yan Li, Yu-Hua Qin, Hong-Min Liu
Ent-kaurane diterpene compounds have attracted considerable attention in recent years due to its antitumor, antibacterial, and antiviral activities. However, the clinical development of natural kaurane diterpenes, for example, oridonin for cancer therapy has been hampered by its relatively moderate potency, limited bioavailability. Herein, we report a newly synthetic analog of natural ent-kaurane diterpene, DS2, which exhibits significantly improved activity of antiproliferation against various cancer cell lines relative to oridonin...
November 15, 2016: Oncotarget
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