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https://www.readbyqxmd.com/read/27902695/text-mining-genotype-phenotype-relationships-from-biomedical-literature-for-database-curation-and-precision-medicine
#1
Ayush Singhal, Michael Simmons, Zhiyong Lu
The practice of precision medicine will ultimately require databases of genes and mutations for healthcare providers to reference in order to understand the clinical implications of each patient's genetic makeup. Although the highest quality databases require manual curation, text mining tools can facilitate the curation process, increasing accuracy, coverage, and productivity. However, to date there are no available text mining tools that offer high-accuracy performance for extracting such triplets from biomedical literature...
November 2016: PLoS Computational Biology
https://www.readbyqxmd.com/read/27837575/dreams-in-ancient-greek-medicine
#2
K Laios, M M Moschos, E Koukaki, E Vasilopoulos, M Karamanou, M-I Kontaxaki, G Androutsos
Dreams preoccupied the Greek and Roman world in antiquity, therefore they had a prominent role in social, philosophical, religious, historical and political life of those times. They were considered as omens and prophetic signs of future events in private and public life, and that was particularly accentuated when elements of actions which took place in the plot of dreams were associated directly or indirectly with real events. This is why it was important to use them in divination, and helped the growth of superstition and folklore believes...
July 2016: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/27815795/charles-william-lacaillade-biologist-parasitologist-educator-and-mentor
#3
Pascal James Imperato
Charles William Lacaillade (1904-1978) was an eminent biologist in the middle decades of the twentieth century. He was born in Lawrence, Massachusetts of parents whose ancestors were French Canadians. His father, also named Charles William Lacaillade, was a dentist who graduated from Tufts University School of Dentistry in 1898. His mother, Elodia Eno, came from a family of very successful businessmen. Lacaillade was the third of six children. His two older brothers, Harold Carleton and Hector Eno, both graduated from the University of Louisville, School of Dentistry, while his younger brother, Lawrence, became a businessman...
November 5, 2016: Journal of Community Health
https://www.readbyqxmd.com/read/27812301/blood-gas-testing-and-related-measurements-national-recommendations-on-behalf-of-the-croatian-society-of-medical-biochemistry-and-laboratory-medicine
#4
REVIEW
Lora Dukić, Lara Milevoj Kopčinović, Adrijana Dorotić, Ivana Baršić
Blood gas analysis (BGA) is exposed to risks of errors caused by improper sampling, transport and storage conditions. The Clinical and Laboratory Standards Institute (CLSI) generated documents with recommendations for avoidance of potential errors caused by sample mishandling. Two main documents related to BGA issued by the CLSI are GP43-A4 (former H11-A4) Procedures for the collection of arterial blood specimens; approved standard - fourth edition, and C46-A2 Blood gas and pH analysis and related measurements; approved guideline - second edition...
October 15, 2016: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://www.readbyqxmd.com/read/27781948/plant-anti-cancer-agents-and-their-biotechnological-production-in-plant-cell-biofactories
#5
Liliana Lalaleo, Abbas Khojasteh, Mohammad Fattahi, Mercedes Bonfill, Rosa M Cusido, Javier Palazon
BACKGROUND: Bioactive plant secondary metabolites have complex chemical structures, which are specific to each plant species/family, and accumulate in tiny amounts. The growing market demand for many phytochemicals can lead to the over-harvesting of medicinal plants in their natural habitat, endangering species in the process. OBJECTIVE: An ongoing challenge for our society is therefore to develop a bio-sustainable production of phytochemicals, among other natural resources...
October 24, 2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/27766937/leveraging-graph-topology-and-semantic-context-for-pharmacovigilance-through-twitter-streams
#6
Ryan Eshleman, Rahul Singh
BACKGROUND: Adverse drug events (ADEs) constitute one of the leading causes of post-therapeutic death and their identification constitutes an important challenge of modern precision medicine. Unfortunately, the onset and effects of ADEs are often underreported complicating timely intervention. At over 500 million posts per day, Twitter is a commonly used social media platform. The ubiquity of day-to-day personal information exchange on Twitter makes it a promising target for data mining for ADE identification and intervention...
October 6, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/27739018/community-based-art-programs-sustaining-adherence-and-follow-up
#7
REVIEW
Joia S Mukherjee, Danika Barry, Robert D Weatherford, Ishaan K Desai, Paul E Farmer
The advent of antiretroviral therapy (ART) in 1996 brought with it an urgent need to develop models of health care delivery that could enable its effective and equitable delivery, especially to patients living in poverty. Community-based care, which stretches from patient homes and communities-where chronic infectious diseases are often best managed-to modern health centers and hospitals, offers such a model, providing access to proximate HIV care and minimizing structural barriers to retention. We first review the recent literature on community-based ART programs in low- and low-to-middle-income country settings and document two key principles that guide effective programs: decentralization of ART services and long-term retention of patients in care...
December 2016: Current HIV/AIDS Reports
https://www.readbyqxmd.com/read/27676949/martials-arts-use-in-physical-and-rehabilitation-medicine-literature-review-and-perspectives
#8
Duong-Minh Nguyen, Isabelle Laffont, Arnaud Dupeyron
OBJECTIVE: Martial arts are physical and meditative discipline available as complementary strategies able to improve functional capacity, physical performances, postural control of patients suffering from chronical diseases. They can probably slow their clinical evolution. The objective of this communication is a review of the literature about the effects of martial arts training into a said chronical disease. MATERIAL/PATIENTS AND METHODS: A literature research in PubMed and Pedro databases was performed with the following keywords: martial arts, rehabilitation, chronic disease, neurologic disorders, heart disease, chronic obstructive pulmonary disease, musculo-squelettal disorders, low back pain...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27652224/the-design-and-methodology-of-premature-ejaculation-interventional-studies
#9
REVIEW
Chris G McMahon
Large well-designed clinical efficacy and safety randomized clinical trials (RCTs) are required to achieve regulatory approval of new drug treatments. The objective of this article is to make recommendations for the criteria for defining and selecting the clinical trial study population, design and efficacy outcomes measures which comprise ideal premature ejaculation (PE) interventional trial methodology. Data on clinical trial design, epidemiology, definitions, dimensions and psychological impact of PE was reviewed, critiqued and incorporated into a series of recommendations for standardisation of PE clinical trial design, outcome measures and reporting using the principles of evidence based medicine...
August 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/27645583/a-systematic-review-on-phenolic-compounds-in-passiflora-plants-exploring-biodiversity-for-food-nutrition-and-popular-medicine
#10
Izabel Lucena Gadioli, Marcela de Sá Barreto da Cunha, Mariana Veras Oliveira de Carvalho, Ana Maria Costa, Lívia de Lacerda de Oliveira Pineli
Passiflora plants are strategic in the context of biodiversity for food and nutrition. We applied the procedures of a systematic review protocol to study the state of the art on identification of phenolic compounds from Passiflora plants. An automated literature search was conducted using six databases and a combination of seven keywords. All the analytical, chromatographic, and spectroscopic methods were included. The studies were classified according to their method of identification, phenolic classes, and method of extraction...
September 19, 2016: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/27636225/an-expert-review-of-pharmacogenomics-of-sickle-cell-disease-therapeutics-not-yet-ready-for-global-precision-medicine
#11
Khuthala Mnika, Gift D Pule, Collet Dandara, Ambroise Wonkam
Sickle cell disease (SCD) is a blood disease caused by a single nucleotide substitution (T > A) in the beta globin gene on chromosome 11. The single point mutation (Glu6Val) promotes polymerization of hemoglobin S (HbS) and causes sickling of erythrocytes. Vaso-occlusive painful crises are associated with recurrent and long-term use of analgesics/opioids and hydroxyurea (HU) by people living with SCD. The present analysis offers a state-of-the-art expert review of the effectiveness of pharmacogenomics/genetics of pain management in SCD, with specific focus on HU and opioids...
October 2016: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/27621117/great-expectations-epigenetics-and-the-meandering-path-from-bench-to-bedside
#12
REVIEW
Sophia J Häfner, Anders H Lund
Making quick promises of major biomedical breakthroughs based on exciting discoveries at the bench is tempting. But the meandering path from fundamental science to life-saving clinical applications can be fraught with many hurdles. Epigenetics, the study of potentially heritable changes of gene function without modification of the underlying DNA sequence, has dominated the biological research field during the last decade and encountered a large public success. Driven by the unfolding of molecular biology and recent technological progress, the term has evolved significantly and shifted from a conceptual framework to a mechanistic understanding...
June 2016: Biomedical Journal
https://www.readbyqxmd.com/read/27565161/what-alert-thresholds-should-be-used-to-identify-critical-risk-results-a-systematic-review-of-the-evidence
#13
Craig A Campbell, Andrew Georgiou, Johanna I Westbrook, Andrea R Horvath
BACKGROUND: Pathology laboratories are required to immediately report results which indicate a patient is at critical risk, but there is little consensus about what values are deemed critical. The aim of this review was to systematically review the literature on alert thresholds for common chemistry and hematology tests in adults and to provide an explicit and ranked source of this evidence. METHODS: The literature search covered the period of 1995-2014. Evidence sources were critically appraised and ranked using the 1999 Stockholm hierarchy for analytical performance specifications in laboratory medicine modified for establishing decision limits...
August 26, 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27532898/integration-of-known-dna-rna-and-protein-biomarkers-provides-prediction-of-anti-tnf-response-in-rheumatoid-arthritis-results-from-the-combine-study
#14
Lasse Folkersen, Boel Brynedal, Lina Marcela Diaz-Gallo, Daniel Ramsköld, Klementy Shchetynsky, Helga Westerlind, Yvonne Sundström, Danika Schepis, Aase Hensvold, Nancy Vivar, Maija-Leena Eloranta, Lars Rönnblom, Søren Brunak, Vivianne Malmström, Anca Catrina, Ulrik Gw Moerch, Lars Klareskog, Leonid Padyukov, Louise Berg
OBJECTIVE: In rheumatoid arthritis (RA) several recent efforts have sought to discover means of predicting which patients would benefit from treatment. However, results have been discrepant with few successful replications. Our objective was to build a biobank with DNA, RNA and protein measurements to test the claim that the current state-of-the-art precision medicine will benefit RA patients. METHODS: We collected 451 blood samples from 61 healthy individuals and 185 RA patients initiating treatment, before treatment initiation and at a 3 month follow-up time...
August 15, 2016: Molecular Medicine
https://www.readbyqxmd.com/read/27493947/minimally-invasive-surgery-for-the-treatment-of-colorectal-cancer
#15
REVIEW
W Konrad Karcz, William von Braun
BACKGROUND: Reduction in operative trauma along with an improvement in endoscopic access has undoubtedly occupied surgical minds for at least the past 3 decades. It is not at all surprising that minimally invasive colon surgery has come a long way since the first laparoscopic appendectomy by Semm in 1981. It is common knowledge that the recent developments in video and robotic technologies have significantly furthered advancements in laparoscopic and minimally invasive surgery. This has led to the overall acceptance of the treatment of benign colorectal pathology via the endoscopic route...
June 2016: Visceral Medicine
https://www.readbyqxmd.com/read/27448453/plants-used-to-treat-diabetes-in-sri-lankan-siddha-medicine-an-ethnopharmacological-review-of-historical-and-modern-sources
#16
Saravanan V Sathasivampillai, Pholtan R S Rajamanoharan, Michael Munday, Michael Heinrich
INTRODUCTION AND BACKGROUND: In recent decades diabetes mellitus has become a considerable health problem in countries like Sri Lanka and results in an increasing economic burden hampering the social and economic development of these countries. About 60 to 70 % of the rural population in Sri Lanka rely on indigenous medicinal systems as their main source for primary health care. Siddha (Tamil) Medicine is one of the four Sri Lankan traditional medicinal systems and it is practised mostly in the eastern and northern provinces of Sri Lanka where the majority of Tamils reside...
July 19, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27436073/future-targets-for-female-sexual-dysfunction
#17
Melissa Farmer, Hana Yoon, Irwin Goldstein
INTRODUCTION: Female sexual function reflects a dynamic interplay of central and peripheral nervous, vascular, and endocrine systems. The primary challenge in the development of novel treatments for female sexual dysfunction is the identification and targeted modulation of excitatory sexual circuits using pharmacologic treatments that facilitate the synthesis, release, and/or receptor binding of neurochemicals, peptides, and hormones that promote female sexual function. AIM: To develop an evidence-based state-of-the-art consensus report that critically integrates current knowledge of the therapeutic potential for known molecular and cellular targets to facilitate the physiologic processes underlying female sexual function...
August 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27411362/clinical-translation-of-tissue-engineered-trachea-grafts
#18
Tendy Chiang, Victoria Pepper, Cameron Best, Ekene Onwuka, Christopher K Breuer
OBJECTIVE: To provide a state-of-the-art review discussing recent achievements in tissue engineered tracheal reconstruction. DATA SOURCES AND REVIEW METHODS: A structured PubMed search of the current literature up to and including October 2015. Representative articles that discuss the translation of tissue engineered tracheal grafts (TETG) were reviewed. CONCLUSIONS: The integration of a biologically compatible support with autologous cells has resulted in successful regeneration of respiratory epithelium, cartilage, and vascularization with graft patency, although the optimal construct composition has yet to be defined...
November 2016: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/27392302/the-clubfoot-over-the-centuries-through-the-documentation-present-in-the-literature-and-art
#19
Ilaria Sanzarello, Matteo Nanni, Cesare Faldini
The aim of this paper is to review all treatment methods of the clubfoot over the years through the documentation present in the literature and art with the aim of better understanding the pathoanatomy of the deformity, but to also clarify factors that allow a safe, logical approach to clubfoot management. The initial part of this paper traces the most representative iconographic representations of clubfoot in history to describe how his presence was witnessed since ancient times. Hippocrates, the father of medicine, was the first to present written references about treatment methods of clubfoot...
July 7, 2016: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/27307387/the-human-epididymis-its-function-in-sperm-maturation
#20
REVIEW
Robert Sullivan, Roger Mieusset
BACKGROUND: Spermatozoa acquire their fertilizing ability and forward motility properties during epididymal transit. Our knowledge of gamete physiology is based on studies conducted in laboratory and domestic species; our knowledge of these processes in humans is limited. Medical indications for assisted reproductive technologies (ART) have progressed to include male infertility. Surgical procedures allow collection of spermatozoa from all along the human excurrent ducts, and the former have been used with some success in reproductive medicine...
September 2016: Human Reproduction Update
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